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MCID: OCL010
MIFTS: 39

Ocular Hypotension

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ocular Hypotension

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MalaCards integrated aliases for Ocular Hypotension:

Name: Ocular Hypotension 12 43 15 71
Hypotony of Eye 12 32

Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:790
ICD9CM 34 360.3
MeSH 43 D015814
SNOMED-CT 67 23670006
ICD10 32 H44.4
UMLS 71 C0028841
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Summaries for Ocular Hypotension

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MalaCards based summary : Ocular Hypotension, also known as hypotony of eye, is related to primary eye hypotony and ocular hypertension, and has symptoms including eye manifestations An important gene associated with Ocular Hypotension is ADRB1 (Adrenoceptor Beta 1), and among its related pathways/superpathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. The drugs Lidocaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related phenotypes are Decreased substrate adherent cell growth and cardiovascular system

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Related Diseases for Ocular Hypotension

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Diseases related to Ocular Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 primary eye hypotony 11.5
2 ocular hypertension 10.7
3 open-angle glaucoma 10.7
4 intraocular pressure quantitative trait locus 10.6
5 glaucoma, primary open angle 10.5
6 cataract 10.2
7 meningococcal infection 10.2 ADRB2 ADRB1
8 yemenite deaf-blind hypopigmentation syndrome 10.1
9 uveitis 10.1
10 macular retinal edema 10.1
11 eye disease 10.1
12 acrodysostosis 10.0 PDE4B PDE4A
13 retinal detachment 9.9
14 glaucoma, normal tension 9.9
15 microvascular complications of diabetes 5 9.9
16 joint laxity, short stature, and myopia 9.9
17 myopia 9.9
18 papilledema 9.9
19 retinal disease 9.9
20 diabetic macular edema 9.9
21 iridocyclitis 9.9
22 complete androgen insensitivity syndrome 9.9
23 dopamine beta-hydroxylase deficiency 9.9 ADRA2B ADRA2A
24 resting heart rate, variation in 9.9 ADRB2 ADRB1 ADRA2B
25 raynaud disease 9.9 ADRA2C ADRA2B
26 keratitis, hereditary 9.8
27 exfoliation syndrome 9.8
28 vitreoretinopathy, neovascular inflammatory 9.8
29 laryngoonychocutaneous syndrome 9.8
30 leprosy 3 9.8
31 macular degeneration, age-related, 1 9.8
32 metabolic acidosis 9.8
33 corneal edema 9.8
34 autonomic neuropathy 9.8
35 blind hypotensive eye 9.8
36 ocular hyperemia 9.8
37 axenfeld-rieger syndrome 9.8
38 vascular disease 9.8
39 optic nerve disease 9.8
40 conjunctivitis 9.8
41 herpes simplex 9.8
42 neuropathy 9.8
43 intrinsic asthma 9.8
44 blepharitis 9.8
45 vitreous detachment 9.8
46 47,xyy 9.8
47 48,xyyy 9.8
48 hansen's disease 9.8
49 pure autonomic failure 9.8
50 rapidly involuting congenital hemangioma 9.8

Comorbidity relations with Ocular Hypotension via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Open-Angle Glaucoma

Graphical network of the top 20 diseases related to Ocular Hypotension:



Diseases related to Ocular Hypotension
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Symptoms & Phenotypes for Ocular Hypotension

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UMLS symptoms related to Ocular Hypotension:


eye manifestations

GenomeRNAi Phenotypes related to Ocular Hypotension according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.8 ADRA1A ADRA1B ADRA2B

MGI Mouse Phenotypes related to Ocular Hypotension:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
2 behavior/neurological MP:0005386 9.87 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB2
3 homeostasis/metabolism MP:0005376 9.76 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
4 mortality/aging MP:0010768 9.56 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
5 muscle MP:0005369 9.1 ADRA1A ADRA1B ADRA2B ADRB1 ADRB2 HTR2B
Sources

Drugs & Therapeutics for Ocular Hypotension

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Drugs for Ocular Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
3
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
4 Anesthetics
5 Adrenergic alpha-Agonists
6 Adrenergic Agents
7 Analgesics, Non-Narcotic
8 Analgesics
9 Hypnotics and Sedatives
10 Anesthetics, Local
11 Adrenergic Agonists
12 Neurotransmitter Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Hyaluronidase on Intraocular Pressure After Retrobulbar Anaesthesia During Cataract Surgery Unknown status NCT03266406 Hyaluronidase
2 Dexmedetomidine as an Additive to Local Anaesthesia to Decrease Intraocular Pressure in Glaucoma Surgery Unknown status NCT02846090 Dexmedetomidine to reduce the IOP
3 Clinical Evaluation of CATS Tonometer Prism Completed NCT02990169

Search NIH Clinical Center for Ocular Hypotension

Cochrane evidence based reviews: ocular hypotension

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Genetic Tests for Ocular Hypotension

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Anatomical Context for Ocular Hypotension

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MalaCards organs/tissues related to Ocular Hypotension:

40
Eye, Brain, Retina
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Publications for Ocular Hypotension

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Articles related to Ocular Hypotension:

(show top 50) (show all 189)
# Title Authors PMID Year
1
Modified Intraocular Lens Intrascleral Fixation Technique Using Two Vitrectomy Ports as Lens Haptic Fixation Sites. 61
32440088 2020
2
Treatment of chronic and extreme ocular hypotension following glaucoma surgery with intraocular platelet-rich plasma: A case report. 61
30295074 2019
3
Use of Intravitreal Injection of Gentamicin in 71 Horses With Equine Recurrent Uveitis. 61
31133325 2019
4
The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. 61
30341781 2019
5
RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis. 61
30456419 2019
6
SILICONE MICROTUBE-ASSISTED SCLERAL FIXATION OF A POSTERIOR CHAMBER INTRAOCULAR LENS. 61
29561385 2018
7
Bilateral corneal denting after surgery under general anesthesia: A case report. 61
29780956 2018
8
Traumatic cyclodialysis treated with transscleral ciclodiode laser: Anterior and posterior segment evolution. 61
28532619 2017
9
[Ocular Hypotension: How the Retina Surgeon Sees the Causes and Therapeutic Options]. 61
27617647 2016
10
[Postoperative Follow-Up of Glaucoma Drainage Devices]. 61
27187881 2016
11
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. 61
26780319 2016
12
Identification of prostamides, fatty acyl ethanolamines, and their biosynthetic precursors in rabbit cornea. 61
26031663 2015
13
[Channelography and mechanism of action in canaloplasty]. 61
25833753 2015
14
Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats. 61
24583339 2014
15
Efficacy and safety of switching to latanoprost 0.005%-timolol maleate 0.5% fixed-combination eyedrops from an unfixed combination for 36 months. 61
25061275 2014
16
Patient satisfaction with topical ocular hypotensives. 61
22594958 2013
17
Correlation between ocular perfusion pressure and ocular pulse amplitude in glaucoma, ocular hypertension, and normal eyes. 61
23966769 2013
18
Dopamine-₃ receptor modulates intraocular pressure: implications for glaucoma. 61
22178719 2012
19
Clinical study on Hypotony following blunt ocular trauma. 61
23275915 2012
20
Ocular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy. 61
21434594 2010
21
[Uveitis in juvenile idiopathic arthritis]. 61
20532786 2010
22
[Advantages and disadvantages of heavy silicone oil]. 61
20532517 2010
23
Morphine-induced ocular hypotension is modulated by nitric oxide and carbon monoxide: role of mu3 receptors. 61
20148660 2010
24
Prolonged ocular hypotension: would ciliary tissue transplantation help. 61
19098698 2009
25
Evaluation of monkey intraocular pressure by rebound tonometer. 61
19898690 2009
26
Acute effects of intravenously administered ethanol on retinal vessel diameters and flicker induced vasodilatation in healthy volunteers. 61
19523476 2009
27
Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow. 61
19234340 2009
28
Latanoprost-induced changes in rat intraocular pressure: direct or indirect? 61
18665807 2008
29
[Clinical characteristics of occult scleral rupture]. 61
18953899 2008
30
Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits. 61
17239401 2007
31
Neuroprotective and intraocular pressure-lowering effects of (-)Delta9-tetrahydrocannabinol in a rat model of glaucoma. 61
17284931 2007
32
Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. 61
17238805 2006
33
Effect of beta radiation on success of glaucoma drainage surgery in South Africa: randomised controlled trial. 61
17023435 2006
34
Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. 61
17076623 2006
35
[Vogt-Koyanagi-Harada disease. Characteristics of a series of Andalusian patients]. 61
16863625 2006
36
Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. 61
16289049 2006
37
Effects of travoprost 0.004% compared with latanoprost 0.005% on the intraocular pressure of normal dogs. 61
16497237 2006
38
Morphine-induced reduction of intraocular pressure and pupil diameter: role of nitric oxide. 61
16534251 2006
39
Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine. 61
15821340 2005
40
Fadolmidine-induced ocular hypotension in normotensive rabbits. 61
15720782 2005
41
[Role of adenosine in intraocular pressure]. 61
15056945 2004
42
PD128,907 induces ocular hypotension in rabbits: involvement of D2/D3 dopamine receptors and brain natriuretic peptide. 61
15006155 2004
43
Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits. 61
14985053 2004
44
Intraocular pressure abnormalities associated with central and hemicentral retinal vein occlusion. 61
14711725 2004
45
[Ocular complications of the virostatic drug cidofovir]. 61
12830392 2003
46
[Ultrasonic biomicroscopic findings after spontaneous resolution of a traumatic cyclodialysis]. 61
12743845 2003
47
Effect of single and multiple doses of 0.2% brimonidine tartrate in the glaucomatous Beagle. 61
12445295 2002
48
Biodegradable calcium phosphate nanoparticles as a new vehicle for delivery of a potential ocular hypotensive agent. 61
12537677 2002
49
Ocular hypotensive action of topical flunarizine in the rabbit: role of sigma 1 recognition sites. 61
12438531 2002
50
Ocular hypotension induced by electroacupuncture. 61
12222760 2002
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Variations for Ocular Hypotension

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Expression for Ocular Hypotension

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Search GEO for disease gene expression data for Ocular Hypotension.
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Pathways for Ocular Hypotension

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Pathways related to Ocular Hypotension according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.87 PDE4B PDE4A HTR2B ADRB2 ADRB1 ADRA2C
2
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.32 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
3
Peptide ligand-binding receptors 65
Show member pathways
 13.32 HTR2B ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4
DAG and IP3 signaling 65
Show member pathways
 12.81 PDE4B PDE4A ADRB2 ADRB1
5
NFAT and Cardiac Hypertrophy 63
Show member pathways
 12.62 ADRB2 ADRB1 ADRA2B ADRA2A ADRA1B ADRA1A
6
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.34 PDE4B ADRB2 ADRB1 ADRA1B ADRA1A
7
Development Dopamine D2 receptor transactivation of EGFR 22
Show member pathways
 12.31 ADRA2C ADRA2B ADRA2A
8
ADP signalling through P2Y purinoceptor 12 65
Show member pathways
 12.23 PDE4B PDE4A ADRB2 ADRA2C ADRA2B ADRA2A
9
cGMP-PKG signaling pathway 36
Show member pathways
 12.2 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
10
cAMP signaling pathway 36
12.17 PDE4B PDE4A ADRB2 ADRB1
11
G-protein signaling G-Protein alpha-i signaling cascades 22
Show member pathways
 12.13 PDE4A ADRB2 ADRB1
12
Calcium signaling pathway 36
Show member pathways
 12.07 HTR2B ADRB2 ADRB1 ADRA1B ADRA1A
13
Salivary secretion 36
Show member pathways
 12.03 ADRB2 ADRB1 ADRA1B ADRA1A
14
G alpha (s) signalling events 65
11.96 PDE4B PDE4A ADRB2 ADRB1
15
AMPK Enzyme Complex Pathway 63
Show member pathways
 11.96 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
16
Ca, cAMP and Lipid Signaling 4
11.85 PDE4B ADRB2 ADRB1
17
Integrin alphaIIb beta3 signaling 65
Show member pathways
 11.73 ADRA2C ADRA2B ADRA2A
18
Antiarrhythmic Pathway, Pharmacodynamics 60
11.47 ADRB2 ADRB1 ADRA2A
19
Regulation of lipolysis in adipocytes 36
11.35 ADRB2 ADRB1
20
Monoamine GPCRs 1
Show member pathways
 11.27 HTR2B ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
21
Surfactant metabolism 65
Show member pathways
 11.22 ADRA2C ADRA2A
22
Endothelin Pathways 1
11.11 ADRB1 ADRA1A
23
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
10.86 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
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GO Terms for Ocular Hypotension

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Cellular components related to Ocular Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.86 HTR2B ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2 membrane GO:0016020 9.85 PDE4B PDE4A HTR2B ADRB2 ADRB1 ADRA2C
3 plasma membrane GO:0005886 9.61 PDE4A HTR2B ADRB2 ADRB1 ADRA2C ADRA2B
4 integral component of postsynaptic membrane GO:0099055 9.32 ADRA2C ADRA1A
5 integral component of plasma membrane GO:0005887 9.23 HTR2B ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Biological processes related to Ocular Hypotension according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 PDE4B PDE4A HTR2B ADRB2 ADRB1 ADRA2C
2 G protein-coupled receptor signaling pathway GO:0007186 9.96 PDE4B PDE4A HTR2B ADRB2 ADRB1 ADRA2C
3 cell-cell signaling GO:0007267 9.91 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
4 positive regulation of MAPK cascade GO:0043410 9.88 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.8 ADRB2 ADRB1 ADRA2A
6 platelet activation GO:0030168 9.78 ADRA2C ADRA2B ADRA2A
7 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.77 HTR2B ADRA1B ADRA1A
8 regulation of smooth muscle contraction GO:0006940 9.76 ADRB2 ADRA2C ADRA2B ADRA2A
9 activation of protein kinase B activity GO:0032148 9.72 ADRA2C ADRA2B ADRA2A
10 regulation of vasoconstriction GO:0019229 9.72 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
11 positive regulation of vasoconstriction GO:0045907 9.71 ADRA2C ADRA1B ADRA1A
12 negative regulation of norepinephrine secretion GO:0010700 9.7 ADRA2C ADRA2B ADRA2A
13 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.7 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
14 receptor transactivation GO:0035624 9.69 ADRA2C ADRA2B ADRA2A
15 negative regulation of autophagy GO:0010507 9.67 HTR2B ADRA1A
16 negative regulation of epinephrine secretion GO:0032811 9.67 ADRA2C ADRA2B ADRA2A
17 activation of adenylate cyclase activity GO:0007190 9.66 ADRB2 ADRB1
18 response to cold GO:0009409 9.66 ADRB2 ADRB1
19 positive regulation of cytokine production GO:0001819 9.65 HTR2B ADRA2A
20 brown fat cell differentiation GO:0050873 9.65 ADRB2 ADRB1
21 activation of phospholipase C activity GO:0007202 9.65 HTR2B ADRA1A
22 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.65 ADRB1 ADRA1B ADRA1A
23 regulation of cardiac muscle contraction GO:0055117 9.64 ADRA1B ADRA1A
24 positive regulation of smooth muscle contraction GO:0045987 9.64 ADRA1B ADRA1A
25 smooth muscle contraction GO:0006939 9.63 HTR2B ADRA1A
26 regulation of muscle contraction GO:0006937 9.63 ADRA1B ADRA1A
27 negative regulation of multicellular organism growth GO:0040015 9.62 ADRB2 ADRB1
28 diet induced thermogenesis GO:0002024 9.61 ADRB2 ADRB1
29 cAMP catabolic process GO:0006198 9.6 PDE4B PDE4A
30 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.58 ADRA1B ADRA1A
31 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.58 ADRB2 ADRB1
32 heat generation GO:0031649 9.57 ADRB2 ADRB1
33 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.56 ADRB1 ADRA1A
34 adrenergic receptor signaling pathway GO:0071875 9.43 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
35 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.17 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B

Molecular functions related to Ocular Hypotension according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
2 G protein-coupled receptor activity GO:0004930 9.76 HTR2B ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3 phosphoric diester hydrolase activity GO:0008081 9.51 PDE4B PDE4A
4 norepinephrine binding GO:0051380 9.5 ADRB2 ADRB1 ADRA2A
5 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.49 PDE4B PDE4A
6 cAMP binding GO:0030552 9.48 PDE4B PDE4A
7 3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 9.46 PDE4B PDE4A
8 alpha-2A adrenergic receptor binding GO:0031694 9.43 ADRB1 ADRA2C
9 alpha2-adrenergic receptor activity GO:0004938 9.43 ADRA2C ADRA2B ADRA2A
10 alpha1-adrenergic receptor activity GO:0004937 9.4 ADRA1B ADRA1A
11 epinephrine binding GO:0051379 9.35 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
12 adrenergic receptor activity GO:0004935 9.17 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
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Sources for Ocular Hypotension

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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