MCID: OCL025
MIFTS: 43

Ocular Toxoplasmosis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

MalaCards integrated aliases for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 53 73
Toxoplasmosis Ocular 55

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 73 C0040561

Summaries for Ocular Toxoplasmosis

NIH Rare Diseases : 53 Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii. Toxoplasmosis is the most common cause of eye inflammation in the world. Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus. Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months. In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. However, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to toxoplasmosis and congenital toxoplasmosis. An important gene associated with Ocular Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Akt Signaling. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and placenta, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 toxoplasmosis 31.6 CCR5 CD40LG CD79A TLR9
2 congenital toxoplasmosis 30.2 CD40LG CD79A TLR9
3 viral infectious disease 29.8 CCR5 CD40LG TLR9
4 human immunodeficiency virus infectious disease 29.7 CCR5 TLR9
5 inflammatory bowel disease 29.1 CCR5 IL17A NOD2 TLR5 TLR9
6 c1q nephropathy 10.2 CD40LG CD79A
7 cryofibrinogenemia 10.2 CD40LG CD79A
8 heparin-induced thrombocytopenia 10.2 CD40LG CD79A
9 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
10 sporotrichosis 10.2 CD40LG CD79A
11 congenital syphilis 10.2 CD40LG CD79A
12 syphilis 10.2 CD40LG CD79A
13 secondary syphilis 10.2 CD40LG CD79A
14 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.2 CD40LG CD79A
15 persistent generalized lymphadenopathy 10.2 CD40LG CD79A
16 erythema infectiosum 10.2 CD40LG TLR9
17 immunoglobulin alpha deficiency 10.2 CD40LG CD79A
18 cryptosporidiosis 10.2 CD40LG CD79A
19 pustulosis palmaris et plantaris 10.2 CD40LG CD79A
20 mesangial proliferative glomerulonephritis 10.2 CCR5 CD79A
21 mucocutaneous leishmaniasis 10.2 CCR5 TLR9
22 dysgerminoma of ovary 10.2 CD40LG CD79A
23 chronic graft versus host disease 10.2 CD79A MICA
24 immune-complex glomerulonephritis 10.2 CCR5 TLR9
25 hypersensitivity reaction type iii disease 10.2 CD79A TLR9
26 marginal zone b-cell lymphoma 10.2 CD40LG CD79A
27 keratoconjunctivitis sicca 10.1 CD79A TLR9
28 cryoglobulinemia 10.1 CD40LG CD79A
29 mature b-cell neoplasm 10.1 CD79A TLR9
30 retinal detachment 10.1
31 amebiasis 10.1 CD79A IL17A
32 bacteriuria 10.1 CD40LG TLR1
33 inflammatory bowel disease 3 10.1 MICA NOD2
34 viral pneumonia 10.1 IL17A TLR9
35 myositis fibrosa 10.1 IL17A TLR9
36 central nervous system vasculitis 10.1 IL17A TLR9
37 meningoencephalitis 10.1 CD40LG CD79A TLR9
38 autoimmune disease of eyes, ear, nose and throat 10.1 IL17A TLR9
39 b cell deficiency 10.1 CD40LG TLR9
40 hypersensitivity reaction type iv disease 10.1 NOD2 TLR9
41 immune deficiency disease 10.1 CD40LG CD79A TLR9
42 yellow fever 10.1 CCR5 TLR9
43 glomerulonephritis 10.1 CD40LG CD79A TLR9
44 uveitis 10.1
45 common variable immunodeficiency 10.1 CD40LG CD79A TLR9
46 suppurative otitis media 10.1 TLR5 TLR9
47 invasive aspergillosis 10.1 TLR1 TLR9
48 neurosyphilis 10.1 IL17A TLR1
49 extrinsic cardiomyopathy 10.1 IL17A TLR9
50 orofacial granulomatosis 10.1 CCR5 CD79A NOD2

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCR5 CD40LG CD79A IL17A NOD2 TLR1
2 digestive/alimentary MP:0005381 9.55 CCR5 IL17A NOD2 TLR5 TLR9
3 immune system MP:0005387 9.23 CCR5 CD40LG CD79A IL17A NOD2 TLR1

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 3 58-05-9 6006 143
2
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
3
Sulfamethoxazole Approved Phase 3 723-46-6 5329
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Antiparasitic Agents Phase 3
6 Folic Acid Antagonists Phase 3
7 Antiprotozoal Agents Phase 3
8 Vitamin B Complex Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 3
10 Antimalarials Phase 3
11 Renal Agents Phase 3
12 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
13 Anti-Bacterial Agents Phase 3
14 Folate Phase 3
15 Anti-Infective Agents Phase 3
16 Anti-Infective Agents, Urinary Phase 3
17 Vitamin B9 Phase 3
18 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
2 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
3 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588 Not Applicable

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

41
Eye, Retina, Placenta, B Cells, Skin, Bone, Colon

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 445)
# Title Authors Year
1
Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort. ( 29788193 )
2018
2
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. ( 29779048 )
2018
3
GENETIC POLYMORPHISMS IN CYTOKINE GENES IN COLOMBIAN PATIENTS WITH OCULAR TOXOPLASMOSIS. ( 29426041 )
2018
4
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. ( 29221851 )
2018
5
Investigation of tissue cysts in the retina in a mouse model of ocular toxoplasmosis: distribution and interaction with glial cells. ( 29858945 )
2018
6
Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients. ( 29642204 )
2018
7
Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29335806 )
2018
8
Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis. ( 29742869 )
2018
9
Current treatment of ocular toxoplasmosis in immunocompetent patients: a network meta-analysis. ( 29704469 )
2018
10
Correction to: Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29858749 )
2018
11
Diagnostic Value of Positive Findings of Toxoplasma gondii-Specific Immunoglobulin M Serum Antibody in Uveitis Patients to Confirm Ocular Toxoplasmosis. ( 29513626 )
2018
12
Regional Differences in the Clinical Manifestation of Ocular Toxoplasmosis between the Center and Northeast of Argentina. ( 29953310 )
2018
13
Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis. ( 28448726 )
2018
14
Comment on: "Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis". ( 29020485 )
2018
15
Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients. ( 29343531 )
2018
16
Surgical outcomes of rhegmatogenous retinal detachment associated with ocular toxoplasmosis. ( 29995119 )
2018
17
Peptidyl-prolyl cis-trans isomerase A - A novel biomarker of multi-episodic (recurrent) ocular toxoplasmosis. ( 30063883 )
2018
18
Evaluating of Wistar rat and BALB/c mouse as animal models for congenital, cerebral and ocular toxoplasmosis. ( 30367763 )
2018
19
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
20
False Negative Toxoplasma Serology in an Immunocompromised Patient with PCR Positive Ocular Toxoplasmosis. ( 28700250 )
2017
21
Seroprevalence and Manifestations of Ocular Toxoplasmosis in Patients with Schizophrenia. ( 29283732 )
2017
22
Causes of visual impairment in patients with ocular toxoplasmosis. ( 28248682 )
2017
23
The use of ELISA, nPCR and qPCR for diagnosis of ocular toxoplasmosis in experimentally infected pigs. ( 28787692 )
2017
24
Corticosteroids as adjuvant therapy for ocular toxoplasmosis. ( 28125765 )
2017
25
Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study. ( 29020481 )
2017
26
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis. ( 28836673 )
2017
27
Ocular Toxoplasmosis: Therapy-Related Adverse Drug Reactions and Their Management. ( 28329892 )
2017
28
T cell immunoregulation in active ocular toxoplasmosis. ( 28214536 )
2017
29
Late isolated ocular toxoplasmosis in a belatacept-treated kidney-transplant patient. ( 27614031 )
2016
30
Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review. ( 27389360 )
2016
31
Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States. ( 27892751 )
2016
32
Clinical Features and Risk Factors of Patients with Presumed Ocular Toxoplasmosis. ( 27195085 )
2016
33
Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists. ( 27598330 )
2016
34
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands. ( 27827450 )
2016
35
Genotyping of Toxoplasma gondii Strains Isolated from Patients with Ocular Toxoplasmosis in Iran. ( 28127336 )
2016
36
Ocular Toxoplasmosis: an Update. ( 27116531 )
2016
37
Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia. ( 26957857 )
2016
38
Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa. ( 26786055 )
2016
39
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
40
Reactivation of Ocular Toxoplasmosis in Non-Hispanic Persons, Misiones Province, Argentina. ( 27089308 )
2016
41
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
42
Acquired ocular toxoplasmosis in a patient with thymoma. ( 25682923 )
2015
43
Ocular toxoplasmosis: background and evidence for an antibiotic prophylaxis. ( 26367087 )
2015
44
Current Therapy of Acquired Ocular Toxoplasmosis: A Review. ( 26226199 )
2015
45
Ocular toxoplasmosis: lessons from Brazil. ( 25956461 )
2015
46
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis. ( 26643197 )
2015
47
Influence of drug therapy on the risk of recurrence of ocular toxoplasmosis. ( 26163541 )
2015
48
MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis. ( 26672749 )
2015
49
IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model. ( 25693767 )
2015
50
Toxoplasma Gondii Infection of Chicken Embryos Causes Retinal Changes and Modulates HSP90B1 Gene Expression: A Promising Ocular Toxoplasmosis Model. ( 26716020 )
2015

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCR5 CD40LG IGHE IL17A NOD2
2
Show member pathways
12.95 CCR5 CD40LG IL17A TLR1 TLR5 TLR9
3
Show member pathways
12.92 CCR5 CD40LG CD79A IGHE IL17A MICA
4
Show member pathways
12.71 NOD2 TLR1 TLR5 TLR9
5
Show member pathways
12.33 CD40LG TLR1 TLR5 TLR9
6
Show member pathways
12.27 CD40LG TLR1 TLR5 TLR9
7
Show member pathways
12.15 CCR5 CD40LG IL17A
8
Show member pathways
11.98 TLR1 TLR5 TLR9
9
Show member pathways
11.92 CCR5 TLR1 TLR5 TLR9
10 11.92 NOD2 TLR1 TLR9
11
Show member pathways
11.87 TLR1 TLR5 TLR9
12 11.87 CD40LG CD79A IL17A TLR1 TLR9
13 11.85 TLR1 TLR5 TLR9
14
Show member pathways
11.64 TLR1 TLR5 TLR9
15
Show member pathways
11.57 IL17A TLR1 TLR5 TLR9
16 11.36 TLR1 TLR5 TLR9
17 11.27 CD40LG TLR9
18 11.12 CD40LG CD79A

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 CCR5 CD40LG CD79A IGHE MICA NOD2
2 cell surface GO:0009986 9.46 CCR5 CD40LG MICA NOD2
3 external side of plasma membrane GO:0009897 9.02 CCR5 CD40LG CD79A IGHE IL17A

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.85 IGHE NOD2 TLR1 TLR5 TLR9
2 immune system process GO:0002376 9.8 CD79A IGHE NOD2 TLR1 TLR5 TLR9
3 cytokine-mediated signaling pathway GO:0019221 9.78 CCR5 IGHE IL17A
4 cellular response to lipopolysaccharide GO:0071222 9.75 CCR5 NOD2 TLR5
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 CD40LG NOD2 TLR9
6 defense response GO:0006952 9.73 CCR5 NOD2 TLR1
7 positive regulation of B cell activation GO:0050871 9.69 IGHE NOD2 TLR9
8 defense response to bacterium GO:0042742 9.65 IGHE MICA NOD2 TLR5 TLR9
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.61 TLR1 TLR5 TLR9
10 toll-like receptor signaling pathway GO:0002224 9.6 TLR1 TLR9
11 B cell proliferation GO:0042100 9.59 CD40LG CD79A
12 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG TLR9
13 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TLR5 TLR9
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.55 IL17A NOD2
15 maintenance of gastrointestinal epithelium GO:0030277 9.54 NOD2 TLR9
16 positive regulation of interleukin-10 production GO:0032733 9.54 CD40LG NOD2 TLR9
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 NOD2 TLR9
18 negative regulation of macrophage apoptotic process GO:2000110 9.49 CCR5 NOD2
19 positive regulation of toll-like receptor signaling pathway GO:0034123 9.48 TLR5 TLR9
20 inflammatory response GO:0006954 9.43 CCR5 CD40LG IL17A TLR1 TLR5 TLR9
21 regulation of cytokine secretion GO:0050707 9.33 TLR1 TLR5 TLR9
22 immune response GO:0006955 9.17 CCR5 CD40LG IGHE IL17A MICA TLR1

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 CD79A TLR1 TLR5 TLR9

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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