MCID: OCL025
MIFTS: 39

Ocular Toxoplasmosis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

MalaCards integrated aliases for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 20 17 70
Toxoplasmosis Ocular 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 70 C0040561

Summaries for Ocular Toxoplasmosis

GARD : 20 Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii. Toxoplasmosis is the most common cause of eye inflammation in the world. Toxoplamosis can be acquired or present at birth ( congenital ), having crossed the placenta from a newly infected mother to her fetus. Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months. In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease. Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. However, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to chorioretinitis and uveitis. An important gene associated with Ocular Toxoplasmosis is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Akt Signaling. The drugs Levoleucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and placenta, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 chorioretinitis 31.4 NOD2 IL17A
2 uveitis 31.1 NOD2 IL17A CCR5
3 congenital toxoplasmosis 31.1 CD79A CD40LG
4 toxoplasmosis 30.9 TLR9 TLR5 CD79A CD40LG CCR5
5 acquired immunodeficiency syndrome 30.5 CD79A CD40LG CCR5
6 vasculitis 30.5 IL17A CD79A CD40LG
7 choroiditis 30.4 NOD2 IL17A
8 panuveitis 30.3 NOD2 IL17A
9 iritis 30.0 NOD2 IL17A
10 syphilis 29.8 IL17A CD79A CD40LG CCR5
11 disease by infectious agent 29.3 TLR9 NOD2 IL17A CCR5
12 ileitis 29.1 TLR5 NOD2 IL17A CCR5
13 immune deficiency disease 29.0 TLR9 IL17A CD79A CD40LG CCR5
14 psoriasis 28.7 TLR9 NOD2 MICA IL17A
15 inflammatory bowel disease 27.8 TLR9 TLR5 TLR1 NOD2 IL17A CD40LG
16 posterior uveitis 10.7
17 neuroretinitis 10.6
18 retinitis 10.5
19 pars planitis 10.5
20 iridocyclitis 10.5
21 retinal detachment 10.5
22 yemenite deaf-blind hypopigmentation syndrome 10.4
23 optic papillitis 10.3
24 hemorrhagic fever-renal syndrome 10.3 CD79A CD40LG
25 c1q nephropathy 10.3 CD79A CD40LG
26 cryofibrinogenemia 10.3 CD79A CD40LG
27 chronic graft versus host disease 10.3 CD79A CCR5
28 episodic angioedema with eosinophilia 10.3 IGHE CD40LG
29 respiratory papillomatosis, juvenile recurrent, congenital 10.2 CD79A CD40LG
30 congenital syphilis 10.2 CD79A CD40LG
31 strabismus 10.2
32 eye disease 10.2
33 mechanical strabismus 10.2
34 exercise-induced anaphylaxis 10.2 IGHE CD79A
35 immunoglobulin a deficiency 1 10.2 CD79A CD40LG
36 pustulosis palmaris et plantaris 10.2 CD79A CD40LG
37 calciphylaxis 10.2 CD79A CD40LG
38 sporotrichosis 10.2 CD79A CD40LG
39 anisakiasis 10.2 IGHE CD79A
40 retinal vasculitis 10.2
41 cataract 10.2
42 pneumocystosis 10.2 CD40LG CCR5
43 persistent generalized lymphadenopathy 10.2 CD79A CD40LG
44 eosinophilic meningitis 10.2 IGHE CD40LG
45 clonorchiasis 10.2 IGHE CD79A
46 strongyloidiasis 10.2 IGHE CD79A
47 infectious posterior uveitis 10.2
48 cryptosporidiosis 10.2 CD79A CD40LG
49 mesangial proliferative glomerulonephritis 10.2 CD79A CCR5
50 immunoglobulin alpha deficiency 10.1 CD79A CD40LG

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCR5 CD40LG CD79A IL17A NOD2 TLR1
2 digestive/alimentary MP:0005381 9.55 CCR5 IL17A NOD2 TLR5 TLR9
3 immune system MP:0005387 9.23 CCR5 CD40LG CD79A IL17A NOD2 TLR1

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
2
Sulfamethoxazole Approved Phase 3 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Folic Acid Antagonists Phase 3
6 Vitamin B9 Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Antiparasitic Agents Phase 3
9 Anti-Infective Agents Phase 3
10 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
11 Vitamin B Complex Phase 3
12 Antimalarials Phase 3
13 Folate Phase 3
14 Anti-Bacterial Agents Phase 3
15 Antiprotozoal Agents Phase 3
16 Immunoglobulin A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Trimethoprim-sulfamethoxazole for the Recurrence of Retinochoroiditis Toxoplasma Gondii Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
2 Comparison of Immunoblotting (IgA and IgG) and the Goldmann-Witmer Coefficient for Diagnosis of Ocular Toxoplasmosis in Immunocompetent Patients Completed NCT03948750
3 Spectral Optical Coherence Tomography Findings in Patients With Ocular Toxoplasmosis : a Retrospective Study Completed NCT04219176
4 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

40
Eye, Retina, Placenta, T Cells, Endothelial, Bone Marrow, Monocytes

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 977)
# Title Authors PMID Year
1
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. 20 61
27723657 2017
2
Cytokine profiles in toxoplasmic and viral uveitis. 54 61
19302012 2009
3
Ocular manifestations in renal allograft recipients: An Indian perspective. 61
33727456 2021
4
Pathogenesis of ocular toxoplasmosis. 61
32717377 2021
5
Aetiology and clinical characteristics of uveitic glaucoma in Turkish patients. 61
33730317 2021
6
Treatment Strategy in Human Ocular Toxoplasmosis: Why Antibiotics Have Failed. 61
33807871 2021
7
Screening for common eye diseases in the elderly with Optos ultra-wide-field scanning laser ophthalmoscopy: a pilot study with focus on ocular toxoplasmosis. 61
33725270 2021
8
Atypical toxoplasmic retinochoroiditis in patients with malignant hematological diseases. 61
32651033 2021
9
Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor. 61
33683297 2021
10
Do we still need a Goldmann-Witmer coefficient for the diagnosis of ocular toxoplasmosis? 61
33279287 2021
11
Ocular Toxoplasmosis after Exposure to Wild Game. 61
33560166 2021
12
Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population. 61
33564078 2021
13
Spiramyin-loaded PLGA implants for the treatment of ocular toxoplasmosis: development, characterization, biocompatibility, and anti-toxoplasma activity. 61
33714282 2021
14
Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort. 61
32345603 2021
15
A case of non-necrotising herpetic retinitis. 61
33612363 2021
16
Clinical manifestations and visual outcomes associated with ocular toxoplasmosis in a Brazilian population. 61
33542439 2021
17
Ocular Toxoplasmosis Mimicking Lymphoma: Exploring the Correlation and Distinction. 61
33659144 2021
18
Driving in Fog without Headlight: Management of a Challenging Case of Presumed Ocular Toxoplasmosis. 61
31577475 2021
19
Bilateral ocular toxoplasmosis in a returning traveller: age and route of infection as potential risk factors. 61
33509864 2021
20
Pathophysiology of ocular toxoplasmosis: Facts and open questions. 61
33382688 2020
21
Interferon-γ and IL-10 Release Assay for Patients with Ocular Toxoplasmosis. 61
32901605 2020
22
Atypical Ocular Toxoplasmosis During Adalimumab Anti-Tumor Necrosis Factor Therapy for Rheumatoid Arthritis. 61
31295158 2020
23
HYPERAUTOFLUORESCENT SPOTS IN ACUTE OCULAR TOXOPLASMOSIS: A New Indicator of Outer Retinal Inflammation. 61
31923122 2020
24
Sequential bilateral Behçet's neuroretinitis associated with prepapillary vitreous exudate: case report. 61
33283258 2020
25
Duffy blood group system and ocular toxoplasmosis. 61
32565360 2020
26
Sulfadiazine plasma concentrations in women with pregnancy-acquired compared to ocular toxoplasmosis under pyrimethamine and sulfadiazine therapy: a case-control study. 61
33228795 2020
27
Serotyping, host genes and cytokines response in human ocular toxoplasmosis. 61
32860878 2020
28
Multimodal Imaging in Ocular Toxoplasmosis. 61
32160073 2020
29
Comparison between the areas of scarred and active toxoplasmic retinochoroiditis. 61
33235345 2020
30
Clinical, Socio-economic and Environmental Factors Related with Recurrences in Ocular Toxoplasmosis in Quindío, Colombia. 61
33115293 2020
31
Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection. 61
32421913 2020
32
Prospective study of serum and aqueous humour anti-Hsp70.1 IgG antibody levels in ocular toxoplasmosis. 61
32602946 2020
33
Putative biomarkers for early diagnosis and prognosis of congenital ocular toxoplasmosis. 61
33028847 2020
34
Disease of the Year 2019: Ocular Toxoplasmosis in HIV-infected Patients. 61
32162993 2020
35
TOXOPLASMOSIS RETINOCHOROIDITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS IN A CASE OF CONGENITAL LONG QT SYNDROME. 61
32910025 2020
36
Heerfordt-Waldenström syndrome, a rare presentation of sarcoidosis in a patient with old ocular toxoplasmosis. 61
32901589 2020
37
Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods. 61
32424529 2020
38
Seronegative ocular toxoplasma panuveitis in an immunocompetent patient. 61
32566798 2020
39
Ocular Toxoplasmosis in Africa: A Narrative Review of the Literature. 61
32976046 2020
40
[Retinal Vein Occlusion - Atypical Primary Manifestation of Ocular Toxoplasmosis]. 61
31652482 2020
41
Acquired ocular toxoplasmosis in an immunocompetent patient. 61
32800416 2020
42
Ocular toxoplasmosis in a patient treated with ustekinumab for psoriasis. 61
32212270 2020
43
Toxoplasma gondii SAG2 type III in an atypical presentation of ocular toxoplasmosis in Indonesia. 61
32413604 2020
44
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection. 61
32482042 2020
45
Severe acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia: Case reports. 61
32195446 2020
46
Bilateral focal choroidal excavations in a patient with Stargardt disease and ocular toxoplasmosis. 61
32486902 2020
47
Spectral optical coherence tomography findings in patients with ocular toxoplasmosis: A case series study. 61
32435471 2020
48
[Prevention of Recurrence of Ocular Toxoplasmosis - When? How? For Whom?] 61
32434243 2020
49
Quality-of-Life and Psychosocial Aspects in Patients with Ocular Toxoplasmosis: A Clinical Study in a Tertiary Care Hospital in Brazil. 61
31589483 2020
50
Isolation of Human Small Extracellular Vesicles and Tracking of their Uptake by Retinal Pigment Epithelial Cells In Vitro. 61
32471212 2020

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 NOD2 IL17A IGHE CD40LG CCR5
2
Show member pathways
12.99 TLR9 TLR5 TLR1 IL17A CD40LG CCR5
3
Show member pathways
12.92 TLR9 TLR5 TLR1 NOD2 MICA IL17A
4
Show member pathways
12.45 TLR9 TLR5 TLR1 NOD2
5
Show member pathways
12.4 TLR9 TLR5 TLR1 CD40LG
6
Show member pathways
12.3 TLR9 IL17A CD40LG CCR5
7
Show member pathways
12.27 TLR9 TLR5 TLR1 CD40LG
8 12.17 TLR9 TLR1 IL17A CD79A CD40LG
9
Show member pathways
12.01 TLR9 TLR5 TLR1
10 11.98 TLR9 TLR1 NOD2
11 11.93 TLR9 TLR5 TLR1
12
Show member pathways
11.92 TLR9 TLR5 TLR1
13
Show member pathways
11.76 TLR9 TLR5 TLR1
14 11.51 TLR9 TLR5 TLR1
15
Show member pathways
11.42 TLR9 TLR5 TLR1 IL17A
16 11.32 TLR9 TLR5 CD40LG
17 11.16 CD79A CD40LG
18
Show member pathways
11.14 TLR9 TLR5 TLR1 IL17A

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.92 TLR9 TLR5 TLR1 MICA IGHE CD79A
2 integral component of plasma membrane GO:0005887 9.65 TLR5 TLR1 MICA CD40LG CCR5
3 plasma membrane GO:0005886 9.61 TLR9 TLR5 TLR1 NOD2 MICA IGHE
4 cell surface GO:0009986 9.46 NOD2 MICA CD40LG CCR5
5 external side of plasma membrane GO:0009897 9.1 MICA IL17A IGHE CD79A CD40LG CCR5

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.95 TLR9 TLR5 TLR1 NOD2 IL17A IGHE
2 defense response to bacterium GO:0042742 9.8 TLR9 TLR5 NOD2 MICA IGHE
3 immune system process GO:0002376 9.8 TLR9 TLR5 TLR1 NOD2 IL17A IGHE
4 cellular response to lipopolysaccharide GO:0071222 9.76 TLR5 NOD2 CCR5
5 positive regulation of interleukin-6 production GO:0032755 9.76 TLR9 TLR1 NOD2 IL17A
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.75 TLR9 NOD2 CD40LG
7 positive regulation of tumor necrosis factor production GO:0032760 9.73 TLR9 TLR1 NOD2 IL17A
8 positive regulation of B cell activation GO:0050871 9.72 TLR9 NOD2 IGHE
9 toll-like receptor signaling pathway GO:0002224 9.7 TLR9 TLR5 TLR1
10 positive regulation of interleukin-10 production GO:0032733 9.69 TLR9 NOD2 CD40LG
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR9 TLR5 TLR1
12 positive regulation of interleukin-8 production GO:0032757 9.67 TLR9 TLR5 TLR1 NOD2
13 inflammatory response GO:0006954 9.63 TLR9 TLR5 TLR1 IL17A CD40LG CCR5
14 B cell proliferation GO:0042100 9.6 CD79A CD40LG
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.59 NOD2 IL17A
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.57 TLR9 NOD2
17 maintenance of gastrointestinal epithelium GO:0030277 9.56 TLR9 NOD2
18 positive regulation of toll-like receptor signaling pathway GO:0034123 9.54 TLR9 TLR5
19 regulation of cytokine secretion GO:0050707 9.5 TLR9 TLR5 TLR1
20 positive regulation of interleukin-12 production GO:0032735 9.26 TLR9 NOD2 IL17A CD40LG
21 immune response GO:0006955 9.23 TLR9 TLR5 TLR1 MICA IL17A IGHE

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 TLR9 TLR5
2 pattern recognition receptor activity GO:0038187 8.96 TLR9 NOD2
3 transmembrane signaling receptor activity GO:0004888 8.92 TLR9 TLR5 TLR1 CD79A

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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