MCID: OCL025
MIFTS: 43

Ocular Toxoplasmosis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

MalaCards integrated aliases for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 54 17 74
Toxoplasmosis Ocular 56

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 74 C0040561

Summaries for Ocular Toxoplasmosis

NIH Rare Diseases : 54 Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii. Toxoplasmosis is the most common cause of eye inflammation in the world. Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus. Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months. In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. However, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to toxoplasmosis and congenital toxoplasmosis. An important gene associated with Ocular Toxoplasmosis is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Akt Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include eye, placenta and t cells, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 toxoplasmosis 31.4 CCR5 CD40LG CD79A TLR9
2 congenital toxoplasmosis 30.0 CD40LG CD79A TLR9
3 human immunodeficiency virus infectious disease 29.6 CCR5 TLR9
4 inflammatory bowel disease 29.5 IL17A NOD2 TLR5
5 c1q nephropathy 10.4 CD40LG CD79A
6 cryofibrinogenemia 10.3 CD40LG CD79A
7 heparin-induced thrombocytopenia 10.3 CD40LG CD79A
8 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
9 sporotrichosis 10.3 CD40LG CD79A
10 congenital syphilis 10.3 CD40LG CD79A
11 syphilis 10.3 CD40LG CD79A
12 secondary syphilis 10.3 CD40LG CD79A
13 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.3 CD40LG CD79A
14 mesangial proliferative glomerulonephritis 10.3 CCR5 CD79A
15 persistent generalized lymphadenopathy 10.3 CD40LG CD79A
16 immunoglobulin alpha deficiency 10.3 CD40LG CD79A
17 cryptosporidiosis 10.3 CD40LG CD79A
18 pustulosis palmaris et plantaris 10.3 CD40LG CD79A
19 chronic graft versus host disease 10.3 CD79A MICA
20 dysgerminoma of ovary 10.3 CD40LG CD79A
21 inflammatory bowel disease 3 10.2 MICA NOD2
22 bacteriuria 10.2 CD79A TLR1
23 marginal zone b-cell lymphoma 10.2 CD40LG CD79A
24 agammaglobulinemia, x-linked 10.2 CD40LG CD79A
25 amebiasis 10.2 CD79A IL17A
26 cryoglobulinemia 10.2 CD40LG CD79A
27 pelvic inflammatory disease 10.2 CD40LG TLR1
28 mucocutaneous leishmaniasis 10.2 CCR5 TLR9
29 orofacial granulomatosis 10.2 CCR5 CD79A NOD2
30 immune-complex glomerulonephritis 10.2 CCR5 TLR9
31 erythema infectiosum 10.2 CD40LG TLR9
32 q fever 10.1 NOD2 TLR1
33 neurosyphilis 10.1 IL17A TLR1
34 hidradenitis suppurativa 10.1 IL17A NOD2
35 hidradenitis 10.1 IL17A NOD2
36 retinal detachment 10.1
37 hypersensitivity reaction type iii disease 10.1 CD79A TLR9
38 irak4 deficiency 10.1 TLR1 TLR5
39 uveitis 10.1
40 myd88 deficiency 10.1 TLR1 TLR5
41 keratoconjunctivitis sicca 10.1 CD79A TLR9
42 exercise-induced anaphylaxis 10.1 CD79A IGHE
43 episodic angioedema with eosinophilia 10.1 CD40LG IGHE
44 hypersensitivity reaction type iv disease 10.1 NOD2 TLR9
45 mature b-cell neoplasm 10.1 CD79A TLR9
46 viral pneumonia 10.0 IL17A TLR9
47 suppurative otitis media 10.0 TLR5 TLR9
48 myositis fibrosa 10.0 IL17A TLR9
49 central nervous system vasculitis 10.0 IL17A TLR9
50 yellow fever 10.0 CCR5 TLR9

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCR5 CD40LG CD79A IL17A NOD2 TLR1
2 digestive/alimentary MP:0005381 9.55 CCR5 IL17A NOD2 TLR5 TLR9
3 immune system MP:0005387 9.23 CCR5 CD40LG CD79A IL17A NOD2 TLR1

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 3 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
3
leucovorin Approved Phase 3 58-05-9 6006 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Cytochrome P-450 Enzyme Inhibitors Phase 3
6 Anti-Bacterial Agents Phase 3
7 Vitamin B Complex Phase 3
8 Anti-Infective Agents Phase 3
9 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
10 Antimalarials Phase 3
11 Antiparasitic Agents Phase 3
12 Anti-Infective Agents, Urinary Phase 3
13 Vitamin B9 Phase 3
14 Folate Phase 3
15 Antiprotozoal Agents Phase 3
16 Folic Acid Antagonists Phase 3
17 Renal Agents Phase 3
18 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
2 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
3 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588 Not Applicable

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

42
Eye, Placenta, T Cells, Testes, Kidney, B Cells, Retina

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 449)
# Title Authors Year
1
Sero-molecular detection, multi-locus genotyping, and clinical manifestations of ocular toxoplasmosis in patients in northwest Iran. ( 30624725 )
2019
2
Effectiveness of Treatments for Ocular Toxoplasmosis. ( 30806556 )
2019
3
Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis. ( 30901349 )
2019
4
Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis. ( 30906227 )
2019
5
Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort. ( 29788193 )
2018
6
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. ( 29779048 )
2018
7
GENETIC POLYMORPHISMS IN CYTOKINE GENES IN COLOMBIAN PATIENTS WITH OCULAR TOXOPLASMOSIS. ( 29426041 )
2018
8
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. ( 29221851 )
2018
9
Investigation of tissue cysts in the retina in a mouse model of ocular toxoplasmosis: distribution and interaction with glial cells. ( 29858945 )
2018
10
Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients. ( 29642204 )
2018
11
Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29335806 )
2018
12
Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis. ( 29742869 )
2018
13
Current treatment of ocular toxoplasmosis in immunocompetent patients: a network meta-analysis. ( 29704469 )
2018
14
Correction to: Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29858749 )
2018
15
Diagnostic Value of Positive Findings of Toxoplasma gondii-Specific Immunoglobulin M Serum Antibody in Uveitis Patients to Confirm Ocular Toxoplasmosis. ( 29513626 )
2018
16
Regional Differences in the Clinical Manifestation of Ocular Toxoplasmosis between the Center and Northeast of Argentina. ( 29953310 )
2018
17
Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients. ( 29343531 )
2018
18
Surgical outcomes of rhegmatogenous retinal detachment associated with ocular toxoplasmosis. ( 29995119 )
2018
19
Peptidyl-prolyl cis-trans isomerase A - A novel biomarker of multi-episodic (recurrent) ocular toxoplasmosis. ( 30063883 )
2018
20
Evaluating of Wistar rat and BALB/c mouse as animal models for congenital, cerebral and ocular toxoplasmosis. ( 30367763 )
2018
21
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
22
False Negative Toxoplasma Serology in an Immunocompromised Patient with PCR Positive Ocular Toxoplasmosis. ( 28700250 )
2017
23
Seroprevalence and Manifestations of Ocular Toxoplasmosis in Patients with Schizophrenia. ( 29283732 )
2017
24
Causes of visual impairment in patients with ocular toxoplasmosis. ( 28248682 )
2017
25
The use of ELISA, nPCR and qPCR for diagnosis of ocular toxoplasmosis in experimentally infected pigs. ( 28787692 )
2017
26
Corticosteroids as adjuvant therapy for ocular toxoplasmosis. ( 28125765 )
2017
27
Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study. ( 29020481 )
2017
28
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis. ( 28836673 )
2017
29
Ocular Toxoplasmosis: Therapy-Related Adverse Drug Reactions and Their Management. ( 28329892 )
2017
30
Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis. ( 28448726 )
2017
31
Comment on: "Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis". ( 29020485 )
2017
32
T cell immunoregulation in active ocular toxoplasmosis. ( 28214536 )
2017
33
Late isolated ocular toxoplasmosis in a belatacept-treated kidney-transplant patient. ( 27614031 )
2016
34
Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review. ( 27389360 )
2016
35
Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States. ( 27892751 )
2016
36
Clinical Features and Risk Factors of Patients with Presumed Ocular Toxoplasmosis. ( 27195085 )
2016
37
Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists. ( 27598330 )
2016
38
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands. ( 27827450 )
2016
39
Genotyping of Toxoplasma gondii Strains Isolated from Patients with Ocular Toxoplasmosis in Iran. ( 28127336 )
2016
40
Ocular Toxoplasmosis: an Update. ( 27116531 )
2016
41
Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia. ( 26957857 )
2016
42
Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa. ( 26786055 )
2016
43
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
44
Reactivation of Ocular Toxoplasmosis in Non-Hispanic Persons, Misiones Province, Argentina. ( 27089308 )
2016
45
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
46
Acquired ocular toxoplasmosis in a patient with thymoma. ( 25682923 )
2015
47
Ocular toxoplasmosis: background and evidence for an antibiotic prophylaxis. ( 26367087 )
2015
48
Current Therapy of Acquired Ocular Toxoplasmosis: A Review. ( 26226199 )
2015
49
Ocular toxoplasmosis: lessons from Brazil. ( 25956461 )
2015
50
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis. ( 26643197 )
2015

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCR5 CD40LG IGHE IL17A NOD2
2
Show member pathways
12.95 CCR5 CD40LG IL17A TLR1 TLR5 TLR9
3
Show member pathways
12.92 CCR5 CD40LG CD79A IGHE IL17A MICA
4
Show member pathways
12.89 NOD2 TLR1 TLR5 TLR9
5
Show member pathways
12.33 CD40LG TLR1 TLR5 TLR9
6
Show member pathways
12.27 CD40LG TLR1 TLR5 TLR9
7
Show member pathways
12.15 CCR5 CD40LG IL17A
8
Show member pathways
11.98 TLR1 TLR5 TLR9
9
Show member pathways
11.92 CCR5 TLR1 TLR5 TLR9
10 11.92 NOD2 TLR1 TLR9
11
Show member pathways
11.87 TLR1 TLR5 TLR9
12 11.87 CD40LG CD79A IL17A TLR1 TLR9
13 11.85 TLR1 TLR5 TLR9
14
Show member pathways
11.64 TLR1 TLR5 TLR9
15
Show member pathways
11.57 IL17A TLR1 TLR5 TLR9
16 11.36 TLR1 TLR5 TLR9
17 11.27 CD40LG TLR9
18 11.12 CD40LG CD79A

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 CCR5 CD40LG CD79A IGHE MICA NOD2
2 cell surface GO:0009986 9.46 CCR5 CD40LG MICA NOD2
3 external side of plasma membrane GO:0009897 9.02 CCR5 CD40LG CD79A IGHE IL17A

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.85 IGHE NOD2 TLR1 TLR5 TLR9
2 immune system process GO:0002376 9.8 CD79A IGHE NOD2 TLR1 TLR5 TLR9
3 cytokine-mediated signaling pathway GO:0019221 9.78 CCR5 IGHE IL17A
4 cellular response to lipopolysaccharide GO:0071222 9.75 CCR5 NOD2 TLR5
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 CD40LG NOD2 TLR9
6 defense response GO:0006952 9.73 CCR5 NOD2 TLR1
7 positive regulation of B cell activation GO:0050871 9.69 IGHE NOD2 TLR9
8 defense response to bacterium GO:0042742 9.65 IGHE MICA NOD2 TLR5 TLR9
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.61 TLR1 TLR5 TLR9
10 toll-like receptor signaling pathway GO:0002224 9.6 TLR1 TLR9
11 B cell proliferation GO:0042100 9.59 CD40LG CD79A
12 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG TLR9
13 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TLR5 TLR9
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.55 IL17A NOD2
15 maintenance of gastrointestinal epithelium GO:0030277 9.54 NOD2 TLR9
16 positive regulation of interleukin-10 production GO:0032733 9.54 CD40LG NOD2 TLR9
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 NOD2 TLR9
18 negative regulation of macrophage apoptotic process GO:2000110 9.49 CCR5 NOD2
19 positive regulation of toll-like receptor signaling pathway GO:0034123 9.48 TLR5 TLR9
20 inflammatory response GO:0006954 9.43 CCR5 CD40LG IL17A TLR1 TLR5 TLR9
21 regulation of cytokine secretion GO:0050707 9.33 TLR1 TLR5 TLR9
22 immune response GO:0006955 9.17 CCR5 CD40LG IGHE IL17A MICA TLR1

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 CD79A TLR1 TLR5 TLR9

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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