MCID: OCL025
MIFTS: 42

Ocular Toxoplasmosis

Categories: Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

MalaCards integrated aliases for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 53 73
Toxoplasmosis Ocular 55

Classifications:



External Ids:

UMLS 73 C0040561

Summaries for Ocular Toxoplasmosis

NIH Rare Diseases : 53 Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii. Toxoplasmosis is the most common cause of eye inflammation in the world. Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus. Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months. In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. However, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to toxoplasmosis and chorioretinitis. An important gene associated with Ocular Toxoplasmosis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and placenta, and related phenotypes are hematopoietic system and immune system

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 toxoplasmosis 31.3 CD40LG CD79A TLR9
2 chorioretinitis 30.3 CD40LG CD79A
3 toxocariasis 29.4 CD40LG IGHE
4 inflammatory bowel disease 28.2 IL17A NOD2 TLR5 TLR9
5 chronic graft versus host disease 10.8 CD79A MICA
6 inflammatory bowel disease 3 10.6 MICA NOD2
7 selective igg deficiency disease 10.6 CD40LG CD79A
8 c1q nephropathy 10.6 CD40LG CD79A
9 meningovascular neurosyphilis 10.6 CD40LG CD79A
10 alpha chain disease 10.6 CD40LG CD79A
11 brill-zinsser disease 10.6 CD40LG CD79A
12 exudative glomerulonephritis 10.6 CD40LG CD79A
13 cork-handlers' disease 10.6 CD40LG CD79A
14 salpingo-oophoritis 10.6 CD40LG CD79A
15 early yaws 10.6 CD40LG CD79A
16 orofacial granulomatosis 10.6 CD79A NOD2
17 ventilation pneumonitis 10.6 CD40LG CD79A
18 chronic interstitial cystitis 10.6 CD40LG CD79A
19 axillary adenitis 10.6 CD40LG CD79A
20 cryofibrinogenemia 10.6 CD40LG CD79A
21 trichostrongyloidiasis 10.6 CD40LG CD79A
22 subacute bacterial endocarditis 10.6 CD40LG CD79A
23 heterophyiasis 10.6 CD40LG CD79A
24 orbital granuloma 10.6 CD40LG CD79A
25 transient hypogammaglobulinemia of infancy 10.6 CD40LG CD79A
26 hyperglobulinemic purpura 10.6 CD40LG CD79A
27 gastroduodenitis 10.6 CD40LG CD79A
28 bacterial conjunctivitis 10.6 CD40LG CD79A
29 heavy chain disease 10.6 CD40LG CD79A
30 ophthalmia neonatorum 10.6 CD40LG CD79A
31 immunoglobulin a deficiency 1 10.6 CD40LG CD79A
32 parotid disease 10.6 CD40LG CD79A
33 cerebral arteritis 10.6 CD40LG CD79A
34 selective immunoglobulin deficiency disease 10.6 CD40LG CD79A
35 geniculate herpes zoster 10.6 CD40LG CD79A
36 erythema elevatum diutinum 10.6 CD40LG CD79A
37 sporotrichosis 10.6 CD40LG CD79A
38 fallopian tube disease 10.6 CD40LG CD79A
39 hyperimmunoglobulin syndrome 10.6 CD40LG CD79A
40 congenital syphilis 10.6 CD40LG CD79A
41 polyclonal hypergammaglobulinemia 10.6 CD40LG CD79A
42 monoclonal paraproteinemia 10.6 CD40LG CD79A
43 salpingitis 10.6 CD40LG CD79A
44 dysgammaglobulinemia 10.6 CD40LG CD79A
45 congenital hypogammaglobulinemia 10.6 CD40LG CD79A
46 acute maxillary sinusitis 10.6 CD40LG CD79A
47 chronic polyneuropathy 10.6 CD40LG CD79A
48 spinocerebellar ataxia, autosomal recessive 10 10.6 CD40LG CD79A
49 parasitic ichthyosporea infectious disease 10.6 CD40LG CD79A
50 cd40 ligand deficiency 10.6 CD40LG CD79A

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 TLR5 TLR9 CD40LG CD79A IL17A NOD2
2 immune system MP:0005387 9.17 TLR5 TLR9 CD40LG CD79A IL17A NOD2

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 3 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
3
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Renal Agents Phase 3
6 Folic Acid Antagonists Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
9 Anti-Bacterial Agents Phase 3
10 Vitamin B Complex Phase 3
11 Anti-Infective Agents Phase 3
12 Antiparasitic Agents Phase 3
13 Antiprotozoal Agents Phase 3
14 Antimalarials Phase 3
15 Folate Nutraceutical Phase 3
16 Vitamin B9 Nutraceutical Phase 3
17 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
2 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
3 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588 Not Applicable

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

41
Eye, Retina, Placenta, T Cells, Testes, B Cells, Kidney

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 429)
# Title Authors Year
1
Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort. ( 29788193 )
2018
2
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. ( 29779048 )
2018
3
GENETIC POLYMORPHISMS IN CYTOKINE GENES IN COLOMBIAN PATIENTS WITH OCULAR TOXOPLASMOSIS. ( 29426041 )
2018
4
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. ( 29221851 )
2018
5
Investigation of tissue cysts in the retina in a mouse model of ocular toxoplasmosis: distribution and interaction with glial cells. ( 29858945 )
2018
6
Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients. ( 29642204 )
2018
7
Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29335806 )
2018
8
Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis. ( 29742869 )
2018
9
Current treatment of ocular toxoplasmosis in immunocompetent patients: a network meta-analysis. ( 29704469 )
2018
10
Correction to: Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29858749 )
2018
11
Diagnostic Value of Positive Findings of Toxoplasma gondii-Specific Immunoglobulin M Serum Antibody in Uveitis Patients to Confirm Ocular Toxoplasmosis. ( 29513626 )
2018
12
Regional Differences in the Clinical Manifestation of Ocular Toxoplasmosis between the Center and Northeast of Argentina. ( 29953310 )
2018
13
Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients. ( 29343531 )
2018
14
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
15
False Negative Toxoplasma Serology in an Immunocompromised Patient with PCR Positive Ocular Toxoplasmosis. ( 28700250 )
2017
16
Seroprevalence and Manifestations of Ocular Toxoplasmosis in Patients with Schizophrenia. ( 29283732 )
2017
17
Causes of visual impairment in patients with ocular toxoplasmosis. ( 28248682 )
2017
18
The use of ELISA, nPCR and qPCR for diagnosis of ocular toxoplasmosis in experimentally infected pigs. ( 28787692 )
2017
19
Corticosteroids as adjuvant therapy for ocular toxoplasmosis. ( 28125765 )
2017
20
Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study. ( 29020481 )
2017
21
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis. ( 28836673 )
2017
22
Ocular Toxoplasmosis: Therapy-Related Adverse Drug Reactions and Their Management. ( 28329892 )
2017
23
Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis. ( 28448726 )
2017
24
T cell immunoregulation in active ocular toxoplasmosis. ( 28214536 )
2017
25
Late isolated ocular toxoplasmosis in a belatacept-treated kidney-transplant patient. ( 27614031 )
2016
26
Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review. ( 27389360 )
2016
27
Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States. ( 27892751 )
2016
28
Clinical Features and Risk Factors of Patients with Presumed Ocular Toxoplasmosis. ( 27195085 )
2016
29
Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists. ( 27598330 )
2016
30
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands. ( 27827450 )
2016
31
Genotyping of Toxoplasma gondii Strains Isolated from Patients with Ocular Toxoplasmosis in Iran. ( 28127336 )
2016
32
Ocular Toxoplasmosis: an Update. ( 27116531 )
2016
33
Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia. ( 26957857 )
2016
34
Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa. ( 26786055 )
2016
35
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
36
Reactivation of Ocular Toxoplasmosis in Non-Hispanic Persons, Misiones Province, Argentina. ( 27089308 )
2016
37
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
38
Acquired ocular toxoplasmosis in a patient with thymoma. ( 25682923 )
2015
39
Ocular toxoplasmosis: background and evidence for an antibiotic prophylaxis. ( 26367087 )
2015
40
Current Therapy of Acquired Ocular Toxoplasmosis: A Review. ( 26226199 )
2015
41
Ocular toxoplasmosis: lessons from Brazil. ( 25956461 )
2015
42
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis. ( 26643197 )
2015
43
Influence of drug therapy on the risk of recurrence of ocular toxoplasmosis. ( 26163541 )
2015
44
MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis. ( 26672749 )
2015
45
IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model. ( 25693767 )
2015
46
Toxoplasma Gondii Infection of Chicken Embryos Causes Retinal Changes and Modulates HSP90B1 Gene Expression: A Promising Ocular Toxoplasmosis Model. ( 26716020 )
2015
47
Interleukin-6-driven inflammatory response induces retinal pathology in a model of ocular toxoplasmosis reactivation. ( 25754200 )
2015
48
Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. ( 26010656 )
2015
49
Volume Rendering of Optical Coherence Tomography Angiography Reveals Extensive Retinal Vascular Contributions to Neovascularization in Ocular Toxoplasmosis. ( 26405767 )
2015
50
Roth Spots in Ocular Toxoplasmosis. ( 26472315 )
2015

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 CD40LG CD79A IGHE IL17A MICA NOD2
2
Show member pathways
13.07 CD40LG IL17A TLR1 TLR5 TLR9
3
Show member pathways
12.69 NOD2 TLR1 TLR5 TLR9
4
Show member pathways
12.46 CD79A TLR1 TLR5 TLR9
5
Show member pathways
12.29 CD40LG TLR1 TLR5 TLR9
6
Show member pathways
12.16 IL17A NOD2 TLR5
7
Show member pathways
11.99 CD40LG TLR1 TLR5 TLR9
8
Show member pathways
11.97 TLR1 TLR5 TLR9
9 11.92 NOD2 TLR1 TLR9
10
Show member pathways
11.85 TLR1 TLR5 TLR9
11 11.83 TLR1 TLR5 TLR9
12
Show member pathways
11.83 IL17A TLR1 TLR5 TLR9
13
Show member pathways
11.67 TLR1 TLR5 TLR9
14 11.54 CD40LG CD79A IL17A TLR1 TLR9
15 11.43 TLR1 TLR5 TLR9
16 11.12 CD40LG CD79A

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.56 CD40LG CD79A IGHE MICA NOD2 TLR1
2 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A IGHE IL17A

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CD40LG IGHE IL17A TLR1
2 innate immune response GO:0045087 9.83 IGHE NOD2 TLR1 TLR5 TLR9
3 immune system process GO:0002376 9.73 CD79A IGHE NOD2 TLR1 TLR5 TLR9
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CD40LG NOD2 TLR9
5 positive regulation of B cell activation GO:0050871 9.65 IGHE NOD2 TLR9
6 positive regulation of tumor necrosis factor production GO:0032760 9.58 NOD2 TLR9
7 toll-like receptor signaling pathway GO:0002224 9.58 TLR1 TLR9
8 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.58 TLR1 TLR5 TLR9
9 B cell proliferation GO:0042100 9.57 CD40LG CD79A
10 positive regulation of interleukin-12 production GO:0032735 9.56 CD40LG TLR9
11 positive regulation of interleukin-8 production GO:0032757 9.54 NOD2 TLR5 TLR9
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.52 IL17A NOD2
13 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 NOD2 TLR9
14 positive regulation of interleukin-10 production GO:0032733 9.5 CD40LG NOD2 TLR9
15 maintenance of gastrointestinal epithelium GO:0030277 9.49 NOD2 TLR9
16 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR5 TLR9
17 inflammatory response GO:0006954 9.43 CD40LG IL17A NOD2 TLR1 TLR5 TLR9
18 regulation of cytokine secretion GO:0050707 9.33 TLR1 TLR5 TLR9
19 defense response to bacterium GO:0042742 9.1 IGHE MICA NOD2 TLR1 TLR5 TLR9

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 CD79A TLR1 TLR5 TLR9

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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