MCID: OCL051
MIFTS: 31

Ocular Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Ocular Tuberculosis

MalaCards integrated aliases for Ocular Tuberculosis:

Name: Ocular Tuberculosis 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0070344

Summaries for Ocular Tuberculosis

Disease Ontology : 12 A tuberculosis that is located in some eye, has material basis in Mycobacterium tuberculosis, and has sypmtom inflamed eyes.

MalaCards based summary : Ocular Tuberculosis is related to scleritis and intermediate uveitis. An important gene associated with Ocular Tuberculosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Th2 Differentiation and Cytokines and Inflammatory Response. The drugs Phenylephrine and Fluorometholone have been mentioned in the context of this disorder. Affiliated tissues include some eye, eye and testes.

Related Diseases for Ocular Tuberculosis

Diseases related to Ocular Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.6 MRAP IFNG
2 intermediate uveitis 30.6 MRAP IFNG
3 posterior uveitis 30.5 MRAP IFNG
4 extrapulmonary tuberculosis 30.2 IFNG CD4
5 retinal vasculitis 30.2 MRAP CD4 ACE
6 posterior scleritis 30.1 MRAP ACE
7 panophthalmitis 30.1 IFNG CD4
8 endophthalmitis 30.1 MRAP CD4
9 panuveitis 30.0 MRAP CD4 ACE
10 iridocyclitis 30.0 MRAP CD4 ACE
11 abdominal tuberculosis 29.9 IFNG CD4
12 cytomegalovirus retinitis 29.9 IFNG CD4
13 macular retinal edema 29.8 MRAP ACE
14 neuroretinitis 29.8 MRAP CD4 ACE
15 choroiditis 29.8 MRAP IFNG CD4 ACE
16 miliary tuberculosis 29.7 IFNG CD4
17 hypopyon 29.7 MRAP CD4
18 pleural tuberculosis 29.7 IFNG CD4
19 multidrug-resistant tuberculosis 29.7 IFNG CD4
20 histoplasmosis 29.7 IFNG CD4
21 papilledema 29.6 CD4 ACE
22 chorioretinitis 29.5 MRAP IFNG CD4 ACE
23 herpes zoster 29.4 IFNG CD4
24 cellulitis 29.2 IFNG CD4
25 optic papillitis 29.2 MRAP CD4 ACE
26 sarcoidosis 1 29.2 MRAP IFNG CD4 ACE
27 syphilis 28.8 MRAP IFNG CD4 ACE
28 uveal disease 28.8 MRAP IFNG CD4 ACE
29 eye disease 28.8 RLBP1 MRAP IFNG CD4 ACE
30 mycobacterium tuberculosis 1 10.7
31 uveitis 10.6
32 vasculitis 10.3
33 brawny scleritis 10.3 IFNG ACE
34 constrictive pericarditis 10.3 IFNG ACE
35 berylliosis 10.3 IFNG ACE
36 cardiac sarcoidosis 10.2 IFNG ACE
37 septic arthritis 10.2 MRAP IFNG
38 hypophosphatasia, childhood 10.2 MRAP ACE
39 macular dystrophy, dominant cystoid 10.2 MRAP ACE
40 tuberculous uveitis 10.2
41 aortic valve insufficiency 10.2 MRAP ACE
42 mycoplasma pneumoniae pneumonia 10.2 IFNG ACE
43 pulmonary tuberculosis 10.2
44 acute pyelonephritis 10.2 IFNG ACE
45 pyelonephritis 10.2 IFNG ACE
46 rheumatic fever 10.1 IFNG ACE
47 chronic graft versus host disease 10.1 IFNG CD4
48 pericardial tuberculosis 10.1 IFNG CD4
49 purulent endophthalmitis 10.1 IFNG CD4
50 latent syphilis 10.1 IFNG CD4

Graphical network of the top 20 diseases related to Ocular Tuberculosis:



Diseases related to Ocular Tuberculosis

Symptoms & Phenotypes for Ocular Tuberculosis

Drugs & Therapeutics for Ocular Tuberculosis

Drugs for Ocular Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenylephrine Approved Phase 3 59-42-7 6041
2
Fluorometholone Approved, Investigational Phase 3 426-13-1 9878
3
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
4
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
5
Ethambutol Approved Phase 3 74-55-5 3279 14052
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
8
Dipivefrin Approved Phase 3 52365-63-6 3105
9
Pyrazinamide Approved, Investigational Phase 3 98-96-4 1046
10
Tropicamide Approved, Investigational Phase 3 1508-75-4 5593
11
Atropine Approved, Vet_approved Phase 3 51-55-8, 5908-99-6 174174
12
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
13 Antitubercular Agents Phase 3
14 Mydriatics Phase 3
15 Anti-Bacterial Agents Phase 3
16 Isoniazid, pyrazinamide, rifampin drug combination Phase 3
17 Ophthalmic Solutions Phase 3
18 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA) Not yet recruiting NCT04117698 Phase 3 Antitubercular treatment (RIFATER ©);Ethambutol;RIFINAH ©

Search NIH Clinical Center for Ocular Tuberculosis

Genetic Tests for Ocular Tuberculosis

Anatomical Context for Ocular Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Ocular Tuberculosis:

19
Some Eye

MalaCards organs/tissues related to Ocular Tuberculosis:

40
Eye, Testes, Retina, Lung, Skin, Endothelial, Neutrophil

Publications for Ocular Tuberculosis

Articles related to Ocular Tuberculosis:

(show top 50) (show all 442)
# Title Authors PMID Year
1
Yellow Sub-Retinal Pigment Epithelium (YSRPE) Deposits: A Novel Sign in Ocular Tuberculosis. 61
32541431 2020
2
Developing a pathway for the diagnosis and management of ocular tuberculosis. The pan-LOndon Ocular tuberculosis Pathway-LOOP. 61
31388132 2020
3
Tuberculous corneal ulcer with hypopyon: A case report. 61
32317491 2020
4
Animal Models of Ocular Tuberculosis: Implications for Diagnosis and Treatment. 61
32407249 2020
5
Ocular Tuberculosis Without a Lung Primary. 61
32494534 2020
6
[Treatment of ocular tuberculosis-an update]. 61
32296921 2020
7
Interstitial Keratitis with Corneal Perforation as the Presenting Sign of Systemic Tuberculosis. 61
30806115 2020
8
The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings. 61
32250731 2020
9
Lessons in Digital Epidemiology from COTS-1: Coordinating Multicentre Research across 10 Countries Using Operational and Technology Innovation to Overcome Funding Deficiencies. 61
32320326 2020
10
Resolution of Large Choroidal Tuberculoma following Monotherapy with Intravitreal Ranibizumab. 61
30986122 2020
11
Management of Intraocular Infections in HIV. 61
32162992 2020
12
Mycobacterium Tuberculosis Modulates Fibroblast Growth Factor and Vascular Endothelial Growth Factor in Ocular Tuberculosis. 61
32160084 2020
13
Ocular Tuberculosis in Human Immunodeficiency Virus and Systemic Tuberculosis Co-infected Patients. 61
32083986 2020
14
Panuveitis revealing Melkersson Rosenthal syndrome: a case report. 61
32395783 2020
15
Presumed ocular tuberculosis in the United Kingdom: a British Ophthalmological Surveillance Unit (BOSU) study. 61
31896802 2020
16
Current Practices in Ocular Tuberculosis: A Survey of Brazilian Specialists. 61
30806119 2020
17
Choroidal Tuberculoma Manifesting in A Patient of Eales Disease 6 Years after Initial Presentation. 61
30339475 2020
18
Presumed Intraocular Tuberculosis Manifesting as Unilateral Iris Granuloma. 61
31944133 2020
19
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis. 61
32115264 2020
20
Tuberculosis: A Cunning Disease Presenting with Endopericarditis-Associated Bilateral Uveitis 61
31893593 2019
21
Standardization of Nomenclature for Ocular Tuberculosis - Results of Collaborative Ocular Tuberculosis Study (COTS) Workshop. 61
31821096 2019
22
Nodular posterior scleritis associated with presumed ocular tuberculosis: A multimodal imaging case report. 61
31650086 2019
23
Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1. 61
31763952 2019
24
Ocular Tuberculosis. 61
31342323 2019
25
Paradoxical reactions in ocular tuberculosis. 61
31493128 2019
26
[Stellate neuroretinitis with choroidal focus in ocular tuberculosis]. 61
31130386 2019
27
Clinical Profile and Treatment Response of Patients with Ocular Inflammation due to Presumed Ocular Tuberculosis: A Retrospective Study 61
31486605 2019
28
THE COLLABORATIVE OCULAR TUBERCULOSIS STUDY (COTS)-1: A Multinational Review of 251 Patients With Tubercular Retinal Vasculitis. 61
29697588 2019
29
An unusual case of tuberculous optic neuropathy associated with choroiditis. 61
31238469 2019
30
Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm. 61
29946830 2019
31
Serpiginoid choroiditis associated with presumed ocular tuberculosis. 61
31198673 2019
32
Familial Blau syndrome:First molecularly confirmed report from India. 61
30574935 2019
33
Role of CT Chest and Cytology in Differentiating Tuberculosis from Presumed Sarcoidosis in Uveitis. 61
29420114 2019
34
A case report of ocular tuberculosis in a patient with membranous nephropathy. 61
30608414 2019
35
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends. 61
29261089 2019
36
Clinical Features of Scleritis Across the Asia-Pacific Region. 61
29953309 2019
37
Utility of routine chest radiography in ocular tuberculosis and sarcoidosis. 61
30355419 2018
38
Opportunistic ocular infections in the setting of HIV. 61
30169465 2018
39
Patterns of uveitis in children at the apex institute for eye care in India: analysis and review of literature. 61
28861733 2018
40
Ocular tuberculosis - A closer look to an increasing reality. 61
30293580 2018
41
[Ocular tuberculosis]. 61
29891262 2018
42
Orbital tuberculosis with involvement of the eyelid: An unusual presentation. 61
31267992 2018
43
Tuberculosis treatment failure in AIDS: vengeance with renal and ocular manifestations. 61
30171156 2018
44
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. 61
30156979 2018
45
Ocular tuberculosis masquerading as a tumor. 61
30064681 2018
46
Global Variations and Challenges With Tubercular Uveitis in the Collaborative Ocular Tuberculosis Study. 61
30120485 2018
47
Subretinal Hypopyon in Presumed Tubercular Uveitis: A Report of Two Cases. 61
30765956 2018
48
[Placoid chorioretinopathy in systemic infections]. 61
29806476 2018
49
The impact of ocular tuberculosis on vision after two months of intensive therapy. 61
29679545 2018
50
[Ocular tuberculosis : A case series]. 61
29580651 2018

Variations for Ocular Tuberculosis

Expression for Ocular Tuberculosis

Search GEO for disease gene expression data for Ocular Tuberculosis.

Pathways for Ocular Tuberculosis

Pathways related to Ocular Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 IFNG CD4
2 10.42 IFNG CD4
3 10.07 IFNG CD4

GO Terms for Ocular Tuberculosis

Biological processes related to Ocular Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 macrophage differentiation GO:0030225 8.62 IFNG CD4

Sources for Ocular Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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