Aliases & Classifications for Oculogyric Crisis

MalaCards integrated aliases for Oculogyric Crisis:

Name: Oculogyric Crisis 12 6 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050842
UMLS 73 C0085637

Summaries for Oculogyric Crisis

Disease Ontology : 12 A focal dystonia that is characterized by a prolonged involuntary upward deviation of the eyes.

MalaCards based summary : Oculogyric Crisis is related to parkinson disease, late-onset and dystonia, and has symptoms including dystonia, dystonia, paroxysmal and dystonia, limb. An important gene associated with Oculogyric Crisis is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Phenylalanine metabolism and Th2 Differentiation Pathway. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and colon, and related phenotypes are Increased viability and homeostasis/metabolism

Wikipedia : 76 Oculogyric crisis (OGC) is the name of a dystonic reaction to certain drugs or medical conditions... more...

Related Diseases for Oculogyric Crisis

Diseases related to Oculogyric Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 parkinson disease, late-onset 29.8 COMT DDC GCH1 MAOB
2 dystonia 10.4
3 gilles de la tourette syndrome 10.2
4 encephalitis 10.2
5 pure autonomic failure 10.1 DDC MAOB
6 brunner syndrome 10.1 COMT MAOB
7 hereditary amyloidosis 10.1 B2M FGA
8 dystonia 3, torsion, x-linked 10.1 ATP1A3 GCH1
9 postencephalitic parkinson disease 10.1 KANTR MAOB
10 dystonia 12 10.1 ATP1A3 GCH1
11 cerebellopontine angle tumor 10.1 JAG1 KANTR
12 antisocial personality disorder 10.1 COMT MAOB
13 obsessive-compulsive disorder 10.1
14 schizophrenia 10.1
15 torticollis 10.1
16 cystic fibrosis 10.1
17 glioma 10.1
18 amphetamine abuse 10.1 KANTR MAOB
19 hemiplegic migraine 10.1 ATP1A3 SLC2A1
20 cardiovascular organ benign neoplasm 10.0 KANTR SLC2A1
21 benign perivascular tumor 10.0 KANTR SLC2A1
22 chronic salpingitis 10.0 KANTR SLC2A1
23 synucleinopathy 10.0 COMT DDC MAOB
24 functional colonic disease 10.0 B2M KANTR
25 mental depression 10.0 COMT DCTN1
26 branch retinal artery occlusion 10.0 B2M KANTR
27 non-gestational choriocarcinoma 10.0 B2M GCH1
28 punctate epithelial keratoconjunctivitis 10.0 B2M KANTR
29 colonic pseudo-obstruction 10.0 B2M KANTR
30 somatoform disorder 9.9 COMT GCH1
31 amyloidosis, familial visceral 9.9 B2M FGA
32 dystonia, dopa-responsive 9.9 ATP1A3 GCH1 SLC2A1
33 dystonia 11, myoclonic 9.9 ATP1A3 GCH1 SLC2A1
34 lymphedema, hereditary, ii 9.9 GCH1 KANTR
35 hemiplegia 9.9 ATP1A3 SLC2A1
36 dopamine beta-hydroxylase deficiency, congenital 9.9 DDC GCH1 KANTR
37 migraine with or without aura 1 9.9 ATP1A3 COMT KANTR MAOB
38 movement disease 9.8 ATP1A3 DDC GCH1 SLC2A1
39 hemidystonia 9.8 ATP1A3 GCH1 JAG1 KANTR
40 dystonia 1, torsion, autosomal dominant 9.7 COMT GCH1 KANTR MAOB
41 aromatic l-amino acid decarboxylase deficiency 9.6 BHLHE41 COMT DDC MAOB SLC25A11

Graphical network of the top 20 diseases related to Oculogyric Crisis:



Diseases related to Oculogyric Crisis

Symptoms & Phenotypes for Oculogyric Crisis

UMLS symptoms related to Oculogyric Crisis:


dystonia, dystonia, paroxysmal, dystonia, limb, eyes rolling

GenomeRNAi Phenotypes related to Oculogyric Crisis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability GR00386-A-1 9.32 ATP1A3 B2M BHLHE41 COMT DCTN1 DDC

MGI Mouse Phenotypes related to Oculogyric Crisis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 ATP1A3 B2M COMT DCTN1 DDC FGA
2 embryo MP:0005380 9.63 COMT DCTN1 DDC FGA JAG1 SLC2A1
3 nervous system MP:0003631 9.32 ATP1A3 B2M COMT DCTN1 DDC FGA

Drugs & Therapeutics for Oculogyric Crisis

Drugs for Oculogyric Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 2 106266-06-2 5073
3 Psychotropic Drugs Phase 2
4 Serotonin Antagonists Phase 2
5 Serotonin Agents Phase 2
6 Dopamine Antagonists Phase 2
7 Central Nervous System Depressants Phase 2
8 Tranquilizing Agents Phase 2
9 Antipsychotic Agents Phase 2
10 Neurotransmitter Agents Phase 2
11 Dopamine Agents Phase 2
12
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia Completed NCT01175135 Phase 2 PF-02545920;PF-02545920;Placebo;Risperidone

Search NIH Clinical Center for Oculogyric Crisis

Genetic Tests for Oculogyric Crisis

Anatomical Context for Oculogyric Crisis

MalaCards organs/tissues related to Oculogyric Crisis:

41
Eye, Testes, Colon

Publications for Oculogyric Crisis

Articles related to Oculogyric Crisis:

(show top 50) (show all 74)
# Title Authors Year
1
Aripiprazole induced neck dystonia and oculogyric crisis. ( 29453150 )
2018
2
Teaching Video NeuroImages: Oculogyric crisis in treated Parkinson disease. ( 29335315 )
2018
3
Tardive Oculogyric Crisis With Low-Dose Antipsychotic in an Adolescent: A Case Report. ( 30476369 )
2018
4
Oculogyric Crisis with Downward Deviation - A Photo Essay. ( 30524493 )
2018
5
Lurasidone-induced Oculogyric Crisis. ( 29200583 )
2017
6
Oculogyric crisis with atypical antipsychotics: A case series. ( 29497196 )
2017
7
Anti-tuberculosis medication-induced oculogyric crisis and the importance of proper history taking. ( 29075142 )
2017
8
Clozapine withdrawal emergent dystonia, oculogyric crisis and rebound psychosis in a single patient. ( 27141293 )
2016
9
Tetrabenazine-induced oculogyric crisis - a rare complication in the treatment of Gilles de la Tourette syndrome. ( 26955276 )
2016
10
Incidence of Oculogyric Crisis and Long-Term Outcomes With Second-Generation Antipsychotics in a First-Episode Psychosis Program. ( 26485339 )
2015
11
Oculogyric Crisis with Clozapine: A Case Report and Review of Similar Case Reports in the Literature. ( 26664086 )
2015
12
Phencyclidine Induced Oculogyric Crisis Responding Well to Conventional Treatment. ( 26101673 )
2015
13
Parkinson's disease presenting with oculogyric crisis in the off period. ( 24694499 )
2014
14
Ondansetron-induced oculogyric crisis. ( 25303969 )
2014
15
Oculogyric crisis in a patient taking metoclopramide. ( 24672222 )
2014
16
Antipsychotic induced chronic recurrent oculogyric crisis in a patient with obsessive compulsive disorder. ( 24908271 )
2014
17
Midazolam Responsive Oculogyric Crisis, Oral Automatisms, Akinesia and Rigidity Induced by Sedation Withdrawal in a Child. ( 30363915 )
2014
18
Tardive oculogyric crisis associated with quetiapine use. ( 23422400 )
2013
19
Metoclopramide-induced oculogyric crisis presenting as encephalitis in a young girl. ( 22529490 )
2012
20
Oculogyric crisis: a rare extrapyramidal side effect in the treatment of Tourette syndrome. ( 22692815 )
2012
21
Aripiprazole-induced oculogyric crisis (acute dystonia). ( 23129969 )
2012
22
Cefixime-induced oculogyric crisis. ( 22217888 )
2012
23
Oculogyric crisis in a midbrain lesion. ( 21403028 )
2011
24
Stereotyped paroxysmal psychiatric symptoms during oculogyric crisis or 'cognitive dystonia': a case report. ( 21047301 )
2011
25
Oculogyric crisis with sertindole monotherapy. ( 20127595 )
2010
26
Tardive oculogyric crisis associated with amisulpride monotherapy. ( 20935407 )
2010
27
Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs. ( 19412963 )
2009
28
Oculogyric crisis with exacerbation of psychosis: Possible mechanism and clinical implications. ( 19121367 )
2009
29
Ziprasidone-related oculogyric crisis in an adult. ( 19717224 )
2009
30
Oculogyric crisis associated with disulfiram-induced pallidonigral lesion. ( 24868355 )
2009
31
Olanzapine-induced tardive oculogyric crisis. ( 19910730 )
2009
32
Case report of oculogyric crisis with ziprasidone in a minor. ( 18615173 )
2008
33
Oculogyric crisis masquerading as ventriculoperitoneal shunt dysfunction. ( 18976089 )
2008
34
Acute oculogyric crisis in a patient taking clebopride. ( 18344644 )
2008
35
Olanzapine-induced oculogyric crisis in a patient with schizophrenia. ( 18603742 )
2008
36
Amisulpride-induced both oculogyric crisis and trismus. ( 18603743 )
2008
37
Quetiapine successfully treating oculogyric crisis induced by antipsychotic drugs. ( 17254790 )
2007
38
Tardive oculogyric crisis during treatment with clozapine: report of three cases. ( 18020545 )
2007
39
Unusual case reports: Tardive oculogyric crisis (tardive syndromes). ( 20661391 )
2007
40
Olanzapine-induced oculogyric crisis. ( 16620322 )
2006
41
Psychiatric symptoms associated with oculogyric crisis: a review of literature for the characterization of antipsychotic-induced episodes. ( 16684678 )
2006
42
Olanzapine-induced oculogyric crisis. ( 16855465 )
2006
43
Isolated oculogyric crisis on clozapine discontinuation. ( 16963596 )
2006
44
A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis. ( 17195428 )
2006
45
Oculogyric crisis in patients taking cetirizine. ( 14962433 )
2004
46
Ziprasidone-induced oculogyric crisis. ( 12964566 )
2003
47
Delayed onset of oculogyric crisis and torticollis with intramuscular haloperidol. ( 14519055 )
2003
48
Risperidone-induced oculogyric crisis. ( 21407993 )
2000
49
Oculogyric crisis as an initial manifestation of Wilson's disease. ( 10331711 )
1999
50
Elimination of oxcarbazepine-induced oculogyric crisis following vagus nerve stimulation. ( 10371552 )
1999

Variations for Oculogyric Crisis

ClinVar genetic disease variations for Oculogyric Crisis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh37 Chromosome 19, 42474436: 42474436
2 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh38 Chromosome 19, 41970284: 41970284
3 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh38 Chromosome 19, 41984953: 41984953
4 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh37 Chromosome 19, 42489105: 42489105

Expression for Oculogyric Crisis

Search GEO for disease gene expression data for Oculogyric Crisis.

Pathways for Oculogyric Crisis

GO Terms for Oculogyric Crisis

Cellular components related to Oculogyric Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 ATP1A3 COMT DCTN1 DDC

Biological processes related to Oculogyric Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.58 COMT GCH1 MAOB
2 protein-containing complex assembly GO:0065003 9.5 FGA GCH1 SLC2A1
3 response to pain GO:0048265 9.37 COMT GCH1
4 dopamine biosynthetic process GO:0042416 9.26 DDC GCH1
5 neuron projection maintenance GO:1990535 9.16 ATP1A3 DCTN1
6 neurotransmitter catabolic process GO:0042135 8.96 COMT MAOB
7 dopamine catabolic process GO:0042420 8.62 COMT MAOB

Sources for Oculogyric Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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