MCID: OCL066
MIFTS: 34

Oculogyric Crisis

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Oculogyric Crisis

MalaCards integrated aliases for Oculogyric Crisis:

Name: Oculogyric Crisis 12 6 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050842
UMLS 73 C0085637

Summaries for Oculogyric Crisis

Disease Ontology : 12 A focal dystonia that is characterized by a prolonged involuntary upward deviation of the eyes.

MalaCards based summary : Oculogyric Crisis is related to dystonia and parkinson disease, late-onset, and has symptoms including dystonia, dystonia, paroxysmal and eyes rolling. An important gene associated with Oculogyric Crisis is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Tyrosine metabolism and Biogenic Amine Synthesis. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased viability and homeostasis/metabolism

Wikipedia : 76 Oculogyric crisis (OGC) is the name of a dystonic reaction to certain drugs or medical conditions... more...

Related Diseases for Oculogyric Crisis

Diseases related to Oculogyric Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 dystonia 29.6 ATP1A3 GCH1 SLC2A1
2 parkinson disease, late-onset 29.0 COMT DDC GCH1 MAOB
3 pure autonomic failure 10.5 DDC MAOB
4 serine deficiency 10.5 DDC SLC2A1
5 brunner syndrome 10.4 COMT MAOB
6 hereditary amyloidosis 10.4 B2M FGA
7 dystonia 3, torsion, x-linked 10.3 ATP1A3 GCH1
8 postencephalitic parkinson disease 10.3 KANTR MAOB
9 dystonia 12 10.3 ATP1A3 GCH1
10 cerebellopontine angle tumor 10.3 JAG1 KANTR
11 antisocial personality disorder 10.3 COMT MAOB
12 hemiplegic migraine 10.3 ATP1A3 SLC2A1
13 amphetamine abuse 10.2 KANTR MAOB
14 chronic salpingitis 10.1 KANTR SLC2A1
15 synucleinopathy 10.1 COMT DDC MAOB
16 functional colonic disease 10.1 B2M KANTR
17 cardiovascular organ benign neoplasm 10.1 KANTR SLC2A1
18 gilles de la tourette syndrome 10.1
19 mental depression 10.1 COMT DCTN1
20 benign perivascular tumor 10.1 KANTR SLC2A1
21 branch retinal artery occlusion 10.1 B2M KANTR
22 non-gestational choriocarcinoma 10.0 B2M GCH1
23 punctate epithelial keratoconjunctivitis 10.0 B2M KANTR
24 amyloidosis, familial visceral 10.0 B2M FGA
25 cranio-facial dystonia 10.0 GCH1 KANTR
26 glomangioma 10.0 KANTR SLC2A1
27 lymphedema, hereditary, ii 10.0 GCH1 KANTR
28 colonic pseudo-obstruction 10.0 B2M KANTR
29 hemiplegia 10.0 ATP1A3 SLC2A1
30 obsessive-compulsive disorder 10.0
31 encephalitis 10.0
32 somatoform disorder 9.9 COMT GCH1
33 dystonia, dopa-responsive 9.8 ATP1A3 GCH1 SLC2A1
34 dystonia 11, myoclonic 9.8 ATP1A3 GCH1 SLC2A1
35 alternating hemiplegia of childhood 9.7 ATP1A3 SLC2A1
36 migraine with or without aura 1 9.6 ATP1A3 COMT KANTR MAOB
37 movement disease 9.5 ATP1A3 DDC GCH1 SLC2A1
38 hemidystonia 9.3 ATP1A3 GCH1 JAG1 KANTR
39 dystonia 1, torsion, autosomal dominant 9.1 COMT GCH1 KANTR MAOB

Graphical network of the top 20 diseases related to Oculogyric Crisis:



Diseases related to Oculogyric Crisis

Symptoms & Phenotypes for Oculogyric Crisis

UMLS symptoms related to Oculogyric Crisis:


dystonia, dystonia, paroxysmal, eyes rolling, dystonia, limb

GenomeRNAi Phenotypes related to Oculogyric Crisis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability GR00386-A-1 9.28 ATP1A3 B2M COMT DCTN1 DDC FGA

MGI Mouse Phenotypes related to Oculogyric Crisis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 B2M COMT DCTN1 DDC FGA GCH1
2 nervous system MP:0003631 9.32 ATP1A3 B2M COMT DCTN1 DDC FGA

Drugs & Therapeutics for Oculogyric Crisis

Drugs for Oculogyric Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 2 106266-06-2 5073
3 Antipsychotic Agents Phase 2
4 Central Nervous System Depressants Phase 2
5 Dopamine Agents Phase 2
6 Dopamine Antagonists Phase 2
7 Neurotransmitter Agents Phase 2
8 Psychotropic Drugs Phase 2
9 Serotonin Agents Phase 2
10 Serotonin Antagonists Phase 2
11 Tranquilizing Agents Phase 2
12
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia Completed NCT01175135 Phase 2 PF-02545920;PF-02545920;Placebo;Risperidone

Search NIH Clinical Center for Oculogyric Crisis

Genetic Tests for Oculogyric Crisis

Anatomical Context for Oculogyric Crisis

MalaCards organs/tissues related to Oculogyric Crisis:

41
Eye

Publications for Oculogyric Crisis

Articles related to Oculogyric Crisis:

(show all 30)
# Title Authors Year
1
Aripiprazole induced neck dystonia and oculogyric crisis. ( 29453150 )
2018
2
Teaching Video NeuroImages: Oculogyric crisis in treated Parkinson disease. ( 29335315 )
2018
3
Lurasidone-induced Oculogyric Crisis. ( 29200583 )
2017
4
Oculogyric crisis with atypical antipsychotics: A case series. ( 29497196 )
2017
5
Anti-tuberculosis medication-induced oculogyric crisis and the importance of proper history taking. ( 29075142 )
2017
6
Clozapine withdrawal emergent dystonia, oculogyric crisis and rebound psychosis in a single patient. ( 27141293 )
2016
7
Tetrabenazine-induced oculogyric crisis - a rare complication in the treatment of Gilles de la Tourette syndrome. ( 26955276 )
2016
8
Incidence of Oculogyric Crisis and Long-Term Outcomes With Second-Generation Antipsychotics in a First-Episode Psychosis Program. ( 26485339 )
2015
9
Oculogyric Crisis with Clozapine: A Case Report and Review of Similar Case Reports in the Literature. ( 26664086 )
2015
10
Phencyclidine Induced Oculogyric Crisis Responding Well to Conventional Treatment. ( 26101673 )
2015
11
Parkinson's disease presenting with oculogyric crisis in the off period. ( 24694499 )
2014
12
Ondansetron-induced oculogyric crisis. ( 25303969 )
2014
13
Oculogyric crisis in a patient taking metoclopramide. ( 24672222 )
2014
14
Antipsychotic induced chronic recurrent oculogyric crisis in a patient with obsessive compulsive disorder. ( 24908271 )
2014
15
Tardive oculogyric crisis associated with quetiapine use. ( 23422400 )
2013
16
Metoclopramide-induced oculogyric crisis presenting as encephalitis in a young girl. ( 22529490 )
2012
17
Oculogyric crisis: a rare extrapyramidal side effect in the treatment of Tourette syndrome. ( 22692815 )
2012
18
Aripiprazole-induced oculogyric crisis (acute dystonia). ( 23129969 )
2012
19
Cefixime-induced oculogyric crisis. ( 22217888 )
2012
20
Oculogyric crisis in a midbrain lesion. ( 21403028 )
2011
21
Stereotyped paroxysmal psychiatric symptoms during oculogyric crisis or 'cognitive dystonia': a case report. ( 21047301 )
2011
22
Oculogyric crisis with sertindole monotherapy. ( 20127595 )
2010
23
Tardive oculogyric crisis associated with amisulpride monotherapy. ( 20935407 )
2010
24
Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs. ( 19412963 )
2009
25
Oculogyric crisis with exacerbation of psychosis: Possible mechanism and clinical implications. ( 19121367 )
2009
26
Ziprasidone-related oculogyric crisis in an adult. ( 19717224 )
2009
27
Oculogyric crisis associated with disulfiram-induced pallidonigral lesion. ( 24868355 )
2009
28
Olanzapine-induced tardive oculogyric crisis. ( 19910730 )
2009
29
Case report of oculogyric crisis with ziprasidone in a minor. ( 18615173 )
2008
30
Oculogyric crisis masquerading as ventriculoperitoneal shunt dysfunction. ( 18976089 )
2008

Variations for Oculogyric Crisis

ClinVar genetic disease variations for Oculogyric Crisis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh37 Chromosome 19, 42474436: 42474436
2 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh38 Chromosome 19, 41970284: 41970284
3 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh37 Chromosome 19, 42489105: 42489105
4 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh38 Chromosome 19, 41984953: 41984953

Expression for Oculogyric Crisis

Search GEO for disease gene expression data for Oculogyric Crisis.

Pathways for Oculogyric Crisis

GO Terms for Oculogyric Crisis

Cellular components related to Oculogyric Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.62 ATP1A3 FGA

Biological processes related to Oculogyric Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.5 COMT GCH1 MAOB
2 response to pain GO:0048265 9.26 COMT GCH1
3 neurotransmitter catabolic process GO:0042135 9.16 COMT MAOB
4 dopamine biosynthetic process GO:0042416 8.96 DDC GCH1
5 dopamine catabolic process GO:0042420 8.62 COMT MAOB

Sources for Oculogyric Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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