MCID: ODN006
MIFTS: 29

Odontoma

Categories: Rare diseases

Aliases & Classifications for Odontoma

MalaCards integrated aliases for Odontoma:

Name: Odontoma 20 54 70

Classifications:



External Ids:

UMLS 70 C0028882

Summaries for Odontoma

MalaCards based summary : Odontoma is related to ameloblastoma and craniopharyngioma. An important gene associated with Odontoma is LHX8 (LIM Homeobox 8), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 An odontoma, also known as an odontome, is a benign tumour linked to tooth development. Specifically, it... more...

Related Diseases for Odontoma

Diseases related to Odontoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 ameloblastoma 29.9 PCNA KRT8 KRT19 KRT18 KRT14
2 craniopharyngioma 29.8 KRT8 KRT5 KRT14
3 basal cell carcinoma 29.5 KRT8 KRT5 KRT19 KRT14
4 odontoma-dysphagia syndrome 11.5
5 calcifying epithelial odontogenic tumor 10.9
6 fibroma 10.6
7 hair whorl 10.4
8 polyp of corpus uteri 10.3 KRT8 KRT14
9 neurenteric cyst 10.3 KRT8 KRT18
10 salpingitis isthmica nodosa 10.3 KRT8 KRT14
11 breast adenomyoepithelioma 10.3 KRT5 KRT14
12 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3
13 idiopathic corneal edema 10.3 KRT8 KRT19
14 rete ovarii adenoma 10.3 KRT8 KRT14
15 rete ovarii benign neoplasm 10.3 KRT8 KRT14
16 lipoadenoma 10.3 KRT19 KRT14
17 ceruminous adenocarcinoma 10.3 KRT5 KRT14
18 adhesive otitis media 10.2 KRT8 KRT18
19 pinguecula 10.2 KRT19 KRT14
20 hidrocystoma 10.2 KRT8 KRT19
21 micronodular basal cell carcinoma 10.2 KRT5 KRT14
22 cryptogenic cirrhosis 10.2 KRT8 KRT18
23 limbal stem cell deficiency 10.2 KRT19 KRT14
24 breast myoepithelial neoplasm 10.2 KRT5 KRT14
25 breast myoepithelial carcinoma 10.2 KRT5 KRT14
26 subareolar duct papillomatosis 10.2 KRT8 KRT5
27 breast metaplastic carcinoma 10.2 KRT5 KRT14
28 nipple benign neoplasm 10.2 KRT8 KRT5
29 large cell acanthoma 10.2 KRT5 KRT14
30 sarcomatous intrahepatic cholangiocarcinoma 10.2 KRT8 KRT19
31 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
32 lipid-rich carcinoma 10.2 KRT5 KRT14
33 sarcomatoid squamous cell skin carcinoma 10.2 KRT8 KRT5
34 intracystic papillary adenoma 10.2 KRT5 KRT14
35 lung clear cell carcinoma 10.2 KRT5 KRT18
36 cystic basal cell carcinoma 10.2 KRT5 KRT14
37 teeth, supernumerary 10.2
38 synchronous bilateral breast carcinoma 10.2 KRT5 KRT14
39 breast osteosarcoma 10.2 KRT8 KRT5
40 vulvar apocrine adenocarcinoma 10.2 KRT5 KRT19
41 pericardium cancer 10.2 KRT5 KRT19
42 cribriform carcinoma 10.2 KRT8 KRT5
43 eccrine sweat gland cancer 10.2 KRT5 KRT19
44 hair follicle neoplasm 10.2 KRT5 KRT14
45 intraductal papilloma 10.2 KRT5 KRT14
46 borst-jadassohn intraepidermal carcinoma 10.2 KRT5 KRT14
47 eccrine acrospiroma 10.2 KRT5 KRT19
48 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
49 nasal cavity olfactory neuroblastoma 10.2 KRT5 KRT19
50 epidermolysis bullosa simplex, generalized 10.2 KRT5 KRT14

Graphical network of the top 20 diseases related to Odontoma:



Diseases related to Odontoma

Symptoms & Phenotypes for Odontoma

GenomeRNAi Phenotypes related to Odontoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.4 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.4 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.4 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.4 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.4 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT5 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18

MGI Mouse Phenotypes related to Odontoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 KRT14 KRT18 KRT19 KRT5 KRT8 LHX8

Drugs & Therapeutics for Odontoma

Search Clinical Trials , NIH Clinical Center for Odontoma

Genetic Tests for Odontoma

Anatomical Context for Odontoma

Publications for Odontoma

Articles related to Odontoma:

(show top 50) (show all 1102)
# Title Authors PMID Year
1
Complex odontoma. 61 54
20478785 2010
2
Differentiation and regenerative capacities of human odontoma-derived mesenchymal cells. 54 61
19281762 2009
3
Unusually large complex odontoma in maxillary sinus associated with unerupted tooth. Report of case and review of literature. 61 54
17891883 2007
4
Large complex odontoma of the left maxillary sinus. 61 54
16416361 2005
5
Odontoma: a clinicopathologic study of 81 cases. 61 54
14976568 2003
6
Three-Dimensional Analysis of Impacted Maxillary and Mandibular Canines and Evaluation of Factors Associated With Transmigration on Cone-Beam Computed Tomography Images. 61
33157051 2021
7
Odontogenic and Developmental Oral Lesions in Pediatric Patients. 61
33723756 2021
8
Active decompression and distraction sugosteogenesis for the treatment of calcifying odontogenic cyst. 61
32676749 2021
9
Hypoxia enhances basal autophagy of epithelial-derived ameloblastoma cells. 61
33721362 2021
10
Impact of changing classification systems on prevalence and frequency distribution of odontogenic tumors in tertiary care center of Nagpur. 61
33757753 2021
11
Spontaneous oral tumours in 18 rabbits (2005-2015). 61
31737910 2021
12
Multiple abnormalities in permanent incisors diagnosed six years after a severe intrusive injury in the primary dentition: A case report. 61
33512071 2021
13
Ameloblastic Fibroodontoma of Mandible Causing Tumor Induced Osteomalacia: A Case Report with Review of 88 Phosphaturic Oral Neoplasms. 61
33394371 2021
14
Analysis of Protein Immunoexpression and Its Interrelationship in the Pathogenesis of Odontomas and Ameloblastic Fibro-Odontomas: A Systematic Review. 61
33394370 2021
15
Peripheral developing odontoma: Is it so rare? 61
32881021 2021
16
Compound odontoma in a nine-years-old boy associated with impacted permanent central and lateral incisor - a case report. 61
33475613 2020
17
Odontoma associated with mandibular transmigrated canine in a geriatric patient: Second case report. 61
33179813 2020
18
Whole Exome Sequencing of SMO, BRAF, PTCH1 and GNAS in Odontogenic Diseases. 61
33144428 2020
19
An unusual case of 177 pieces of mandibular compound odontoma: 10-year follow-up. 61
32220610 2020
20
Unusual giant complex odontoma: A case report. 61
31904531 2020
21
New World Health Organization classification of odontogenic tumours: impact on the prevalence of odontogenic tumours and analysis of 1231 cases from Turkey. 61
32684315 2020
22
Mural unicystic ameloblastoma with multifarious histopathological patterns: An exquisite case report. 61
33433524 2020
23
Complex odontoma at the upper right maxilla: Surgical management and histomorphological profile. 61
32893652 2020
24
Peripheral compound odontoma: A rare case report and literature review. 61
32134132 2020
25
Hybrid Odontogenic Tumor of Calcifying Odontogenic Cyst and Ameloblastic Fibroma: a Case Report and Review of Literature. 61
32582832 2020
26
Customized surgical guide with a bite block and retraction arm for a deeply impacted odontoma; a technical note. 61
32416286 2020
27
Evaluation of dentofacial asymmetry caused by odontomas using panoramic radiographs. 61
32134025 2020
28
Dental and maxillofacial features of Noonan Syndrome: Case series of ten patients. 61
32113883 2020
29
Focal cemento-osseous dysplasia: A case report with a review of literature. 61
32189897 2020
30
Primordial odontogenic tumour or developing odontoma? 61
31545527 2020
31
Rare dental developmental disturbance in primary and permanent teeth following trauma prior to tooth eruption: Case report. 61
31234235 2020
32
Ameloblastic Fibro-Odontoma Misidentified as an Enamel Pearl. 61
32151310 2020
33
[Comprehensive treatment of a child with an extensive composite odontoma]. 61
32692523 2020
34
Middle ear odontoma: A case report and review of the literature. 61
32066114 2020
35
Case Report: An association of the gubernacular canal, supernumerary tooth and odontoma with an impacted canine on cone-beam computed tomography. 61
33604026 2020
36
New WHO odontogenic tumor classification: impact on prevalence in a population. 61
31778444 2020
37
Sequelae in permanent teeth after traumatic injuries to primary dentition. 61
32052622 2019
38
Eruption disturbance caused by an odontoma that was partially attached to the crown of the adjacent maxillary first molar, and step lesion excavation for the tooth preservation: A case report. 61
31893080 2019
39
Evaluation of biopsies of oral and maxillofacial lesions: a retrospective study. 61
31966976 2019
40
Odontoma. 61
31760790 2019
41
Interceptive management of ectopically erupting central incisor - A case report. 61
31710018 2019
42
Odontomas are associated with impacted permanent teeth in orthodontic patients. 61
31636870 2019
43
Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses. 61
31359553 2019
44
Association between odontoma size, age and gender: Multivariate analysis of retrospective data. 61
31598198 2019
45
[Odontogenic tumors and odontogenic cysts: a clinical and pathological analysis of 4 181 cases]. 61
31378034 2019
46
Ameloblastic fibro-odontoma in a 14 year old girl: A case report. 61
31169249 2019
47
Comparison of Hematoxylin and Eosin Stain with Modified Gallego's Stain for Differentiating Mineralized Components in Ossifying Fibroma, Cemento-ossifying Fibroma, and Cementifying Fibroma. 61
31548923 2019
48
Case of odontoma-related infection in a cleidocranial dysplasia. 61
31296636 2019
49
Sequential Removal of a Large Odontoma in the Angle of the Mandible. 61
31909030 2019
50
Atypical Intracranial Compound Simil Odontoma. 61
31166272 2019

Variations for Odontoma

Expression for Odontoma

Search GEO for disease gene expression data for Odontoma.

Pathways for Odontoma

Pathways related to Odontoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 KRT8 KRT5 KRT19 KRT18 KRT14
2 11.92 VIM TUBB3 KRT8 KRT5 KRT19 KRT18
3 11.67 VIM NES KRT19
4 11.48 KRT19 KRT18 KRT14
5 11.3 VIM PCNA KRT8
6
Show member pathways
11.26 VIM TUBB3 NES KRT8 KRT5 KRT19
7 10.95 KRT8 KRT19

GO Terms for Odontoma

Cellular components related to Odontoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.11 VIM TUBB3 PCNA LHX8 KRT8 KRT5
2 extracellular exosome GO:0070062 9.86 VIM TUBB3 PCNA KRT8 KRT5 KRT19
3 intermediate filament cytoskeleton GO:0045111 9.5 VIM NES KRT8
4 keratin filament GO:0045095 9.46 KRT8 KRT5 KRT18 KRT14
5 apicolateral plasma membrane GO:0016327 9.43 KRT8 KRT19
6 costamere GO:0043034 9.4 KRT8 KRT19
7 dystrophin-associated glycoprotein complex GO:0016010 9.37 KRT8 KRT19
8 cell periphery GO:0071944 9.26 KRT8 KRT19 KRT18 KRT14
9 intermediate filament GO:0005882 9.17 VIM NES KRT8 KRT5 KRT19 KRT18

Biological processes related to Odontoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.55 VIM PCNA KRT8 KRT19 KRT18
2 extrinsic apoptotic signaling pathway GO:0097191 9.43 KRT8 KRT18
3 sarcomere organization GO:0045214 9.4 KRT8 KRT19
4 hemidesmosome assembly GO:0031581 9.37 KRT5 KRT14
5 keratinization GO:0031424 9.35 KRT8 KRT5 KRT19 KRT18 KRT14
6 hepatocyte apoptotic process GO:0097284 9.32 KRT8 KRT18
7 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19
8 cornification GO:0070268 9.02 KRT8 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Odontoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.43 KRT19 KRT18 KRT14
2 scaffold protein binding GO:0097110 9.26 VIM KRT8 KRT5 KRT18
3 keratin filament binding GO:1990254 9.16 VIM KRT14
4 structural constituent of cytoskeleton GO:0005200 9.02 VIM TUBB3 KRT5 KRT19 KRT14

Sources for Odontoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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