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MCID: OLG020
MIFTS: 46

Oligoarticular Juvenile Idiopathic Arthritis

Categories: Bone diseases, Eye diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards integrated aliases for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 58 17 71
Juvenile Pauciarticular Chronic Arthritis 71
Pauciarticular Chronic Arthritis 58
Oligoarticular Jia 58

Characteristics:

Orphanet epidemiological data:

58
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Respiratory diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

ICD10 via Orphanet 33 M08.4
UMLS via Orphanet 72 C2931171
Orphanet 58 ORPHA85410
UMLS 71 C2931171 C3898105
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Summaries for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to uveitis and juvenile rheumatoid arthritis. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is ANKRD55 (Ankyrin Repeat Domain 55), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Etanercept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and eye, and related phenotypes are arthralgia and joint swelling

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Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

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Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.9 TNF IL2RA CXCR3 CCR5
2 juvenile rheumatoid arthritis 30.5 TNF STAT4 MIF IL2RB IL2RA HLA-DRB1
3 herpes zoster 30.5 TNF HLA-DRB1 CCR5
4 optic neuritis 29.9 TNF IL2RA HLA-DRB1 CXCR3 CCR5
5 takayasu arteritis 29.6 TNF PTPN22 HLA-DRB1 HLA-DPB1
6 arthritis 28.8 TNF TGFB1 STAT4 PTPN22 MIF HLA-DRB1
7 autoimmune disease 27.1 TNF TGFB1 STAT4 PTPN22 MIF IL2RA
8 inflammatory bowel disease 25.5 TNF TGFB1 STAT4 PTPN22 PTPN2 MIF
9 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 12.7
10 oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies 12.7
11 pauciarticular chronic arthritis 12.6
12 juvenile arthritis 11.0
13 iridocyclitis 10.5
14 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
15 achalasia, familial esophageal 10.4 HLA-DQB1 HLA-DQA1
16 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
17 plica syndrome 10.4
18 synovitis 10.4
19 neonatal lupus erythematosus 10.4 HLA-DQA1 HLA-DPB1
20 hypersomnia 10.4 HLA-DRB1 HLA-DQB1
21 narcolepsy 2 10.4 HLA-DRB1 HLA-DQB1
22 type ii mixed cryoglobulinemia 10.4 HLA-DRB1 HLA-DQB1
23 moyamoya angiopathy 10.4 HLA-DRB1 HLA-DQB1
24 juvenile myasthenia gravis 10.4 TGFB1 HLA-DRB1
25 recurrent respiratory papillomatosis 10.4 HLA-DRB1 HLA-DQB1
26 psoriatic arthritis 10.3
27 pauciarticular onset juvenile idiopathic arthritis 10.3
28 microscopic polyangiitis 10.3 TNF HLA-DRB1
29 orofacial granulomatosis 10.3 TNF CXCR3 CCR5
30 apple allergy 10.3 HLA-DRB1 HLA-DQB1 HLA-DPB1
31 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
32 autoimmune hepatitis type 1 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
33 focal epithelial hyperplasia 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
34 idiopathic bronchiectasis 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
35 secondary progressive multiple sclerosis 10.3 CXCR3 CCR8 CCR5
36 pediatric multiple sclerosis 10.2 HLA-DRB1 HLA-DQB1
37 ileitis 10.2 TNF CCR8 CCR5
38 leukemia, acute lymphoblastic 3 10.2
39 idiopathic nephrotic syndrome 10.2 TGFB1 HLA-DRB1
40 acute disseminated encephalomyelitis 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
41 cicatricial pemphigoid 10.2 TGFB1 HLA-DRB1 HLA-DQB1
42 nontuberculous mycobacterial lung disease 10.2 TNF HLA-DRB1
43 eosinophilia-myalgia syndrome 10.2 TGFB1 HLA-DRB1 HLA-DQA1
44 osteonecrosis of the jaw 10.2 TGFB1 HLA-DRB1 HLA-DQB1
45 autoimmune hepatitis 10.2 TNF HLA-DRB1 HLA-DQB1
46 syphilis 10.2 TNF HLA-DRB1 CCR5
47 metal allergy 10.2 TNF HLA-DRB1 HLA-DQB1
48 pustulosis palmaris et plantaris 10.2 TNF TGFB1 CXCR3
49 sympathetic ophthalmia 10.2 TNF HLA-DRB1 HLA-DQA1
50 whipple disease 10.2 TNF HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis
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Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

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Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 joint swelling 58 31 hallmark (90%) Very frequent (99-80%) HP:0001386
3 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
4 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
5 juvenile rheumatoid arthritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0005681
6 antinuclear antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0003493
7 iridocyclitis 58 31 frequent (33%) Frequent (79-30%) HP:0001094

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQA1
2 cellular MP:0005384 10.23 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
3 endocrine/exocrine gland MP:0005379 10.22 BMP4 CD247 CREM CXCR2 HLA-DQA1 HLA-DQB1
4 immune system MP:0005387 10.2 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DQA1
5 cardiovascular system MP:0005385 10.18 BMP4 CCR5 CREM CXCR2 CXCR3 HLA-DQB1
6 digestive/alimentary MP:0005381 10.03 BMP4 CCR5 HLA-DQB1 IL2RA PTPN2 PTPN22
7 mortality/aging MP:0010768 10 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
8 liver/biliary system MP:0005370 9.91 BMP4 CCR5 CREM CXCR2 HLA-DQB1 IL2RB
9 reproductive system MP:0005389 9.61 BMP4 CCR5 CD247 CREM CXCR2 HLA-DQB1
10 respiratory system MP:0005388 9.28 BMP4 CREM CXCR2 CXCR3 HLA-DQB1 IL2RA
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Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

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Drugs for Oligoarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 3 185243-69-0
2
Adalimumab Approved Phase 3 331731-18-1 16219006
3
tannic acid Approved Phase 3 1401-55-4
4
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
5
Abatacept Approved Phase 3 332348-12-6 10237
6 Analgesics, Non-Narcotic Phase 3
7 Gastrointestinal Agents Phase 3
8 Analgesics Phase 3
9 Rheumatoid Factor Phase 3
10 Immunologic Factors Phase 3
11 Immunosuppressive Agents Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antirheumatic Agents Phase 3
15 Immunoglobulins
16 Antibodies
17 Antibodies, Antinuclear

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 2-Part Open-Label Study to Assess the Clinical Benefit and Long-Term Safety of Etanercept in Children and Adolescents With Extended Oligoarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, or Psoriatic Arthritis Completed NCT00962741 Phase 3 Etanercept
2 AN OPEN-LABEL EXTENSION STUDY TO ASSESS THE LONG-TERM SAFETY AND CLINICAL BENEFIT OF ETANERCEPT IN CHILDREN AND ADOLESCENTS WITH EXTENDED OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR PSORIATIC ARTHRITIS WHO WERE PREVIOUSLY ENROLLED IN PROTOCOL 0881A1-3338-WW(B1801014) Active, not recruiting NCT01421069 Phase 3 etanercept
3 Treatment Tapering in Oligoarticular or Rheumatoid Factor Negative Polyarticular Juvenile Idiopathic Arthritis With Inactive Disease on Biologic Therapy Active, not recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
4 A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) Suspended NCT03841357 Phase 3 Abatacept Injection
5 Usefulness of Protoarray®Microarray for Identifying Biomarkers in Idiopathic Juvenile Arthritis Antinuclear Antibodies Positive. Unknown status NCT02343770

Search NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

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Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

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Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

40
Bone, T Cells, Eye, B Cells, Endothelial
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Publications for Oligoarticular Juvenile Idiopathic Arthritis

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Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show top 50) (show all 65)
# Title Authors PMID Year
1
Evaluation of ocular surface and meibomian glands in patients with uveitis related to oligoarticular juvenile idiopathic arthritis. 61
32270334 2020
2
Tumefactive synovial thickening mimicking synovial chondromatosis in the setting of oligoarticular juvenile idiopathic arthritis in a toddler. 61
31890072 2020
3
A clinical score to guide in decision making for monogenic type I IFNopathies. 61
31641281 2020
4
Benign transient hyperphosphatasemia in Juvenile Idiopathic Arthritis: a case report. 61
32281964 2019
5
Rice Bodies in a Patient with Oligoarticular Juvenile Idiopathic Arthritis. 61
31474614 2019
6
Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections. 61
31299977 2019
7
Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial. 61
31122296 2019
8
Intra-articular joint injections in juvenile idiopathic arthritis: state of the art. 61
30243614 2019
9
Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis. 61
30930898 2019
10
A novel mutation in NCF2 resulting in very-early-onset colitis and juvenile idiopathic arthritis in a patient with chronic granulomatous disease. 61
31832070 2019
11
Lyme Arthritis in Children on the Uptick in Western New York Area. 61
31819695 2019
12
Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis. 61
29025853 2018
13
The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. 61
29925386 2018
14
Low synovial double negative T and γδ T cells predict longer free-disease survival in oligoarticular JIA. 61
29059705 2018
15
Takayasu arteritis with an initial presentation of chronic monoarthritis mimicking oligoarticular juvenile idiopathic arthritis. 61
30069294 2018
16
Juvenile idiopathic arthritis in a patient with previous diagnosis of severe congenital lupus. 61
28649905 2018
17
The DNA methylation landscape of CD4+ T cells in oligoarticular juvenile idiopathic arthritis. 61
28969936 2018
18
Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable. 61
29310668 2018
19
Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship? 61
28052441 2017
20
Juvenile Idiopathic Arthritis. 61
28418334 2017
21
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial. 61
28162781 2017
22
SUBRETINAL CANNULATION AS A COMPLICATION OF SUTURE TRABECULOTOMY SURGERY IN A PEDIATRIC PATIENT. 61
26967964 2017
23
Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. 61
28086918 2017
24
Sleep Fragmentation and Biomarkers in Juvenile Idiopathic Arthritis. 61
26512051 2016
25
Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. 61
24131380 2014
26
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. 61
23696632 2014
27
The role of transforming growth factor β signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor β signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. 61
24782191 2014
28
Re: oligoarticular juvenile idiopathic arthritis among Saudi children. 61
24894793 2014
29
Serum TNF-α levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. 61
24839823 2014
30
Oligoarticular juvenile idiopathic arthritis among Saudi children. 61
24413854 2013
31
Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register. 61
23267169 2013
32
Disease activity and fatigue in juvenile idiopathic arthritis. 61
22807336 2013
33
Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis. 61
21647665 2012
34
Timing of uveitis onset in oligoarticular juvenile idiopathic arthritis (JIA) is the main predictor of severe course uveitis. 61
20039849 2012
35
Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation. 61
21621220 2011
36
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. 61
21962036 2011
37
Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. 61
21813070 2011
38
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. 61
21707991 2011
39
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. 61
21385553 2011
40
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. 61
20352219 2010
41
Oligoclonal expansion of T cells in persistent oligoarticular juvenile idiopathic arthritis. 61
20659414 2010
42
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study. 61
20403210 2010
43
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. 61
20127724 2010
44
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. 61
19933594 2010
45
HLA-DQA1 gene expression profiling in oligoarticular JIA. 61
19811310 2009
46
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. 61
19804628 2009
47
CXCR6-CXCL16 interaction in the pathogenesis of Juvenile Idiopathic Arthritis. 61
18760678 2008
48
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. 61
18078632 2007
49
Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis. 61
17469159 2007
50
Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis. 61
16504994 2006
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Variations for Oligoarticular Juvenile Idiopathic Arthritis

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Expression for Oligoarticular Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.
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Pathways for Oligoarticular Juvenile Idiopathic Arthritis

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Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.05 TNF TGFB1 PTPN22 PTPN2 MIF IL2RB
2
ERK Signaling 63
Show member pathways
 13.85 TNF TGFB1 STAT4 IL2RB IL2RA CXCR3
3
PEDF Induced Signaling 63
Show member pathways
 13.7 TNF TGFB1 MIF IL2RB IL2RA CXCR3
4
Akt Signaling 63
Show member pathways
 13.41 TNF TGFB1 STAT4 IL2RB IL2RA CXCR3
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.38 TNF TGFB1 PTPN2 IL2RB IL2RA HLA-DRB1
6
PAK Pathway 63
Show member pathways
 13.24 TNF TGFB1 PTPN22 PTPN2 IL2RB IL2RA
7
IL-2 Pathway 63
Show member pathways
 13.21 TNF STAT4 IL2RB IL2RA HLA-DRB1 HLA-DQB1
8
Allograft rejection 1 36
Show member pathways
 12.89 TNF TGFB1 IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
9
CCR5 Pathway in Macrophages 63
Show member pathways
 12.85 CXCR3 CXCR2 CD247 CCR8 CCR5
10
Measles 36
Show member pathways
 12.85 TNF IL2RB IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
11
Pathways in cancer 36
12.82 TGFB1 STAT4 IL2RB IL2RA BMP4
12
Herpes simplex virus 1 infection 36
12.78 TNF HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
13
Immune response NFAT in immune response 22
Show member pathways
 12.69 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
14
NF-kappaB Signaling 4
12.62 TNF STAT4 PTPN22 PTPN2 IL2RB IL2RA
15
Interferon gamma signaling 65
Show member pathways
 12.55 PTPN2 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
16
JAK-STAT signaling pathway 36
Show member pathways
 12.47 STAT4 PTPN2 IL2RB IL2RA CCR5
17
ICos-ICosL Pathway in T-Helper Cell 63
Show member pathways
 12.46 IL2RB IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 CD247
18
TCR signaling (REACTOME) 65
Show member pathways
 12.42 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
19
Endocytosis 36
12.39 IL2RB IL2RA CXCR2 CCR5
20
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 TNF IL2RB IL2RA CXCR3 CXCR2 CCR8
21
Tuberculosis 36
12.3 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
22
CD28 co-stimulation 65
Show member pathways
 12.27 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
23
Phagosome 36
12.15 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
24
Cell adhesion molecules (CAMs) 36
12.14 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
25
Jak Stat Signaling Pathway 66
Show member pathways
 12.09 STAT4 IL2RB IL2RA
26
Adipogenesis 1
12.08 TNF TGFB1 MIF BMP4
27
Toxoplasmosis 36
Show member pathways
 12.08 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
28
IL12-mediated signaling events 1
Show member pathways
 12.02 STAT4 IL2RB IL2RA HLA-DRB1 CD247 CCR5
29
S-1P Stimulated Signaling 63
12 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
30
Translocation of ZAP-70 to Immunological synapse 65
Show member pathways
 11.99 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
31
MHC class II antigen presentation 65
11.96 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
32
Staphylococcus aureus infection 36
11.93 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
33
Human T-cell leukemia virus 1 infection 36
11.9 TNF TGFB1 IL2RB IL2RA HLA-DRB1 HLA-DQB1
34
GPCRs, Other 1
11.89 CXCR3 CXCR2 CCR5
35
Hematopoietic cell lineage 36
11.88 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
36
Th17 cell differentiation 36
Show member pathways
 11.86 TNF TGFB1 STAT4 IL2RB IL2RA HLA-DRB1
37
Innate Lymphoid Cells Differentiation 64
11.85 TNF IL2RB IL2RA CXCR3
38
TGF-beta signaling pathway (KEGG) 36
11.84 TNF TGFB1 BMP4
39
CTLA4 Signaling 63
11.81 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD247
40
Rheumatoid arthritis 36
11.77 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
41
G-protein signaling N-RAS regulation pathway 22
Show member pathways
 11.73 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.69 TNF STAT4 IL2RB IL2RA CD247
43
TGF-beta Receptor Signaling (WikiPathways) 1
11.62 TNF TGFB1 BMP4
44
Th2 Differentiation 64
11.51 STAT4 IL2RB IL2RA
45
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.46 TNF TGFB1 IL2RB IL2RA
46
Cytokines and Inflammatory Response 1
11.29 TNF TGFB1 HLA-DRB1
47
IL12 signaling mediated by STAT4 1
11 TGFB1 STAT4 IL2RA HLA-DRB1 CD247
48
RXR and RAR heterodimerization with other nuclear receptor 1
10.84 TNF TGFB1
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GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

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Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.34 TNF PTPN2 IL2RB IL2RA HLA-DRB1 HLA-DQB1
2 plasma membrane GO:0005886 10.31 TNF TGFB1 PTPN2 MIF IL2RB IL2RA
3 integral component of plasma membrane GO:0005887 10.11 TNF IL2RB HLA-DRB1 HLA-DQA1 CXCR3 CXCR2
4 endosome membrane GO:0010008 9.84 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
5 trans-Golgi network membrane GO:0032588 9.78 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
6 endocytic vesicle membrane GO:0030666 9.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.71 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
8 transport vesicle membrane GO:0030658 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.56 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
11 external side of plasma membrane GO:0009897 9.56 TNF IL2RB IL2RA HLA-DRB1 CXCR3 CXCR2
12 interleukin-2 receptor complex GO:0005893 9.49 IL2RB IL2RA
13 MHC class II protein complex GO:0042613 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
14 cell surface GO:0009986 9.32 TNF TGFB1 MIF IL2RB IL2RA HLA-DRB1

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 TGFB1 STAT4 IL2RB HLA-DRB1 CXCR3 CXCR2
2 immune system process GO:0002376 10.11 PTPN22 MIF IL2RA HLA-DRB1 HLA-DQA1 HLA-DPB1
3 negative regulation of gene expression GO:0010629 10 TNF TGFB1 PTPN22 MIF BMP4
4 MAPK cascade GO:0000165 9.97 TNF TGFB1 IL2RB IL2RA CCR5
5 regulation of cell proliferation GO:0042127 9.96 TNF TGFB1 STAT4 MIF
6 chemotaxis GO:0006935 9.94 CXCR3 CXCR2 CCR8 CCR5
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 CXCR3 CXCR2 CCR8 CCR5
8 positive regulation of protein phosphorylation GO:0001934 9.89 TNF TGFB1 MIF HLA-DRB1 BMP4
9 cell surface receptor signaling pathway GO:0007166 9.88 MIF IL2RA CXCR3 CXCR2 CD247 CCR5
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 TNF TGFB1 MIF
11 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.86 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
12 cytokine-mediated signaling pathway GO:0019221 9.85 TNF TGFB1 STAT4 IL2RB IL2RA CCR5
13 positive regulation of MAP kinase activity GO:0043406 9.83 TNF TGFB1 MIF
14 cell chemotaxis GO:0060326 9.83 CXCR3 CXCR2 CCR8 CCR5
15 calcium-mediated signaling GO:0019722 9.81 CXCR3 CXCR2 CCR8 CCR5
16 negative regulation of T cell proliferation GO:0042130 9.8 TGFB1 IL2RA HLA-DRB1
17 inflammatory response GO:0006954 9.8 TNF TGFB1 MIF IL2RA CXCR3 CXCR2
18 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.79 TNF TGFB1 BMP4
19 T cell differentiation GO:0030217 9.78 TGFB1 PTPN22 PTPN2
20 chemokine-mediated signaling pathway GO:0070098 9.78 CXCR3 CXCR2 CCR8 CCR5
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TGFB1 PTPN22
22 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
23 negative regulation of myoblast differentiation GO:0045662 9.72 TNF TGFB1 BMP4
24 positive regulation of SMAD protein signal transduction GO:0060391 9.7 TGFB1 BMP4
25 negative regulation of immune response GO:0050777 9.69 TGFB1 IL2RA
26 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.69 TNF MIF
27 positive regulation of vascular permeability GO:0043117 9.68 TGFB1 CXCR2
28 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TGFB1 BMP4
29 interleukin-2-mediated signaling pathway GO:0038110 9.68 IL2RB IL2RA
30 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TNF TGFB1
31 response to cholesterol GO:0070723 9.67 TGFB1 CCR5
32 negative regulation of lipid storage GO:0010888 9.67 TNF PTPN2
33 regulation of protein import into nucleus GO:0042306 9.67 TGFB1 BMP4
34 positive regulation of mononuclear cell migration GO:0071677 9.65 TNF TGFB1
35 common-partner SMAD protein phosphorylation GO:0007182 9.65 TGFB1 BMP4
36 regulation of leukocyte migration GO:0002685 9.65 PTPN22 CXCR3
37 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.64 HLA-DRB1 HLA-DQB1
38 regulation of cartilage development GO:0061035 9.63 TGFB1 BMP4
39 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.63 TNF TGFB1 PTPN22 MIF HLA-DRB1 BMP4
40 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.62 HLA-DRB1 HLA-DQB1
41 antigen processing and presentation GO:0019882 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
42 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.61 HLA-DRB1 HLA-DQA1 HLA-DPB1
43 regulation of pri-miRNA transcription by RNA polymerase II GO:1902893 9.58 TGFB1 BMP4
44 T cell receptor signaling pathway GO:0050852 9.43 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
45 immune response GO:0006955 9.32 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.41 TNF TGFB1 STAT4 PTPN22 PTPN2 MIF
2 identical protein binding GO:0042802 10.07 TNF TGFB1 STAT4 MIF CXCR3 CD247
3 cytokine activity GO:0005125 9.81 TNF TGFB1 MIF BMP4
4 peptide antigen binding GO:0042605 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
5 chemokine binding GO:0019956 9.56 CXCR3 CXCR2 CCR8 CCR5
6 MHC class II receptor activity GO:0032395 9.54 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 non-membrane spanning protein tyrosine phosphatase activity GO:0004726 9.49 PTPN22 PTPN2
8 C-X-C chemokine receptor activity GO:0016494 9.48 CXCR3 CXCR2
9 C-C chemokine binding GO:0019957 9.46 CXCR3 CXCR2 CCR8 CCR5
10 interleukin-2 binding GO:0019976 9.43 IL2RB IL2RA
11 interleukin-2 receptor activity GO:0004911 9.4 IL2RB IL2RA
12 C-C chemokine receptor activity GO:0016493 9.26 CXCR3 CXCR2 CCR8 CCR5
13 chemokine receptor activity GO:0004950 8.92 CXCR3 CXCR2 CCR8 CCR5
Sources

Sources for Oligoarticular Juvenile Idiopathic Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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68 SNOMED-CT via HPO
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70 Tocris
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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