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MCID: OLG020
MIFTS: 47

Oligoarticular Juvenile Idiopathic Arthritis

Categories: Bone diseases, Eye diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards integrated aliases for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 60 17 74
Juvenile Pauciarticular Chronic Arthritis 74
Pauciarticular Chronic Arthritis 60
Oligoarticular Jia 60

Characteristics:

Orphanet epidemiological data:

60
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Respiratory diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare eye diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

ICD10 via Orphanet 35 M08.4
UMLS via Orphanet 75 C2931171
Orphanet 60 ORPHA85410
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Summaries for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to juvenile rheumatoid arthritis and uveitis. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include bone, eye and t cells, and related phenotypes are joint swelling and arthralgia

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Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

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Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 juvenile rheumatoid arthritis 31.3 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA TNF
2 uveitis 30.9 CXCR3 IL2RA TNF
3 arthritis 30.8 HLA-DQB1 HLA-DRB1 MIF PTPN22 STAT4 TGFB1
4 optic neuritis 30.7 CCR5 HLA-DRB1 TNF
5 takayasu arteritis 30.5 HLA-DPB1 HLA-DQA1 HLA-DRB1 TNF
6 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 12.5
7 oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies 12.5
8 pauciarticular chronic arthritis 12.5
9 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
10 achalasia, familial esophageal 10.4 HLA-DQA1 HLA-DQB1
11 narcolepsy 2 10.4 HLA-DQB1 HLA-DRB1
12 juvenile myasthenia gravis 10.4 HLA-DRB1 TGFB1
13 autoimmune polyglandular syndrome type 3 10.4 HLA-DQB1 HLA-DRB1
14 hypersomnia 10.4 HLA-DQB1 HLA-DRB1
15 systemic onset juvenile idiopathic arthritis 10.4 MIF TNF
16 cytomegalovirus retinitis 10.4 CCR5 HLA-DQB1 TNF
17 endometritis 10.3 HLA-DQA1 HLA-DQB1 TNF
18 orofacial granulomatosis 10.3 CCR5 CXCR3 TNF
19 pustulosis palmaris et plantaris 10.3 CXCR3 TGFB1 TNF
20 microscopic polyangiitis 10.3 HLA-DRB1 TNF
21 metal allergy 10.3 HLA-DQB1 HLA-DRB1
22 microscopic colitis 10.3 HLA-DQB1 HLA-DRB1 TNF
23 lichen planopilaris 10.3 HLA-DQB1 HLA-DRB1
24 osteonecrosis of the jaw 10.3 HLA-DQB1 HLA-DRB1 TGFB1
25 sympathetic ophthalmia 10.3 HLA-DQA1 HLA-DRB1 TNF
26 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1 TGFB1
27 neonatal lupus erythematosus 10.3 HLA-DPB1 HLA-DQA1
28 guillain-barre syndrome 10.3 HLA-DQA1 HLA-DQB1 TNF
29 type ii mixed cryoglobulinemia 10.3 HLA-DQB1 HLA-DRB1
30 geographic tongue 10.3 HLA-DQB1 HLA-DRB1 TNF
31 panuveitis 10.3 HLA-DQB1 HLA-DRB1 TNF
32 idiopathic bronchiectasis 10.3 HLA-DQA1 HLA-DQB1 HLA-DRB1
33 acute disseminated encephalomyelitis 10.3 HLA-DQA1 HLA-DQB1 HLA-DRB1
34 recurrent respiratory papillomatosis 10.3 HLA-DQB1 HLA-DRB1
35 rheumatic fever 10.3 HLA-DQA1 HLA-DRB1 TNF
36 focal epithelial hyperplasia 10.3 HLA-DQA1 HLA-DQB1 HLA-DRB1
37 chagas disease 10.3 CCR5 TGFB1 TNF
38 membranous nephropathy 10.3 HLA-DQA1 TGFB1 TNF
39 rheumatoid vasculitis 10.3 HLA-DRB1 MIF TNF
40 narcolepsy 1 10.3 HLA-DQB1 HLA-DRB1
41 toxoplasmosis 10.3 CCR5 HLA-DQA1 HLA-DQB1 TNF
42 rheumatic heart disease 10.2 HLA-DQA1 HLA-DRB1 TGFB1 TNF
43 berylliosis 10.2 HLA-DPB1 HLA-DRB1
44 chronic beryllium disease 10.2 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
45 glaucomatocyclitic crisis 10.2 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
46 palindromic rheumatism 10.2 HLA-DRB1 PTPN22 TNF
47 narcolepsy 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1 TNF
48 leishmaniasis 10.2 HLA-DQA1 HLA-DQB1 HLA-DRB1 TNF
49 autoimmune disease of central nervous system 10.2 CCR5 CXCR3 HLA-DRB1 TNF
50 rubella 10.2 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis
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Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

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Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

60 33 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint swelling 60 33 hallmark (90%) Very frequent (99-80%) HP:0001386
2 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
3 elevated c-reactive protein level 60 33 hallmark (90%) Very frequent (99-80%) HP:0011227
4 elevated erythrocyte sedimentation rate 60 33 hallmark (90%) Very frequent (99-80%) HP:0003565
5 antinuclear antibody positivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0003493
6 juvenile rheumatoid arthritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0005681
7 iridocyclitis 60 33 frequent (33%) Frequent (79-30%) HP:0001094

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQA1
2 cellular MP:0005384 10.27 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
3 endocrine/exocrine gland MP:0005379 10.27 BMP4 CD247 CREM CXCR2 HLA-DQA1 HLA-DQB1
4 immune system MP:0005387 10.24 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DQA1
5 homeostasis/metabolism MP:0005376 10.18 BMP4 CCR5 CXCR2 CXCR3 HLA-DQB1 IL2RA
6 cardiovascular system MP:0005385 10.16 BMP4 CCR5 CREM CXCR2 CXCR3 HLA-DQB1
7 mortality/aging MP:0010768 10.1 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
8 digestive/alimentary MP:0005381 10.08 BMP4 CCR5 HLA-DQB1 IL2RA PTPN2 PTPN22
9 liver/biliary system MP:0005370 9.97 BMP4 CCR5 CREM CXCR2 HLA-DQB1 IL2RB
10 renal/urinary system MP:0005367 9.7 BMP4 CXCR2 CXCR3 HLA-DQB1 PTPN22 STAT4
11 reproductive system MP:0005389 9.61 BMP4 CCR5 CD247 CREM CXCR2 HLA-DQB1
12 respiratory system MP:0005388 9.28 BMP4 CREM CXCR2 CXCR3 HLA-DQB1 IL2RA
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Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

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Search Clinical Trials , NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

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Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

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Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

42
Bone, Eye, T Cells, B Cells, Skin, Heart, Thyroid
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Publications for Oligoarticular Juvenile Idiopathic Arthritis

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Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show all 38)
# Title Authors Year
1
Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis. ( 30930898 )
2019
2
The DNA methylation landscape of CD4+ T cells in oligoarticular juvenile idiopathic arthritis. ( 28969936 )
2018
3
Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis. ( 29025853 )
2018
4
The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. ( 29925386 )
2018
5
Takayasu arteritis with an initial presentation of chronic monoarthritis mimicking oligoarticular juvenile idiopathic arthritis. ( 30069294 )
2018
6
Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship? ( 28052441 )
2017
7
Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. ( 28086918 )
2017
8
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial. ( 28162781 )
2017
9
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. ( 23696632 )
2014
10
Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. ( 24131380 )
2014
11
The role of transforming growth factor β signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor β signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. ( 24782191 )
2014
12
Serum TNF-α levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. ( 24839823 )
2014
13
Re: oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24894793 )
2014
14
Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register. ( 23267169 )
2013
15
Oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24413854 )
2013
16
Timing of uveitis onset in oligoarticular juvenile idiopathic arthritis (JIA) is the main predictor of severe course uveitis. ( 20039849 )
2012
17
Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis. ( 21647665 )
2012
18
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. ( 21707991 )
2011
19
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. ( 21385553 )
2011
20
Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation. ( 21621220 )
2011
21
Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. ( 21813070 )
2011
22
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. ( 21962036 )
2011
23
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. ( 19933594 )
2010
24
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. ( 20127724 )
2010
25
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. ( 20352219 )
2010
26
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study. ( 20403210 )
2010
27
Oligoclonal expansion of T cells in persistent oligoarticular juvenile idiopathic arthritis. ( 20659414 )
2010
28
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. ( 19804628 )
2009
29
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. ( 18078632 )
2007
30
The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. ( 15703957 )
2006
31
A polymorphic variant inside the osteopontin gene shows association with disease course in oligoarticular juvenile idiopathic arthritis. ( 16150788 )
2006
32
Is there a role for arthroscopic synovectomy in oligoarticular juvenile idiopathic arthritis? ( 16881093 )
2006
33
Optic neuritis associated with etanercept therapy in two patients with extended oligoarticular juvenile idiopathic arthritis. ( 15637094 )
2005
34
Low-dose methotrexate treatment for oligoarticular juvenile idiopathic arthritis nonresponsive to intra-articular corticosteroids. ( 15877178 )
2005
35
Comparison of intra-articular triamcinolone hexacetonide and triamcinolone acetonide in oligoarticular juvenile idiopathic arthritis. ( 12810938 )
2003
36
Proinflammatory responses to self HLA epitopes are triggered by molecular mimicry to Epstein-Barr virus proteins in oligoarticular juvenile idiopathic arthritis. ( 12384932 )
2002
37
Early predictors of severe course of uveitis in oligoarticular juvenile idiopathic arthritis. ( 12415607 )
2002
38
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. ( 11371669 )
2001
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Variations for Oligoarticular Juvenile Idiopathic Arthritis

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Expression for Oligoarticular Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.
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Pathways for Oligoarticular Juvenile Idiopathic Arthritis

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Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.02 CCR5 CD247 CXCR2 HLA-DPB1 HLA-DQA1 HLA-DQB1
2
ERK Signaling 65
Show member pathways
 13.87 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
3
PEDF Induced Signaling 65
Show member pathways
 13.69 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
4
Akt Signaling 65
Show member pathways
 13.38 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.35 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
6
IL-2 Pathway 65
Show member pathways
 13.21 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB STAT4
7
PAK Pathway 65
Show member pathways
 13.21 BMP4 CCR5 CCR8 CXCR2 CXCR3 IL2RA
8
Human cytomegalovirus infection 38
Show member pathways
 12.97 CCR5 CCR8 CD247 CXCR2 STAT4 TGFB1
9
Allograft rejection 38 1
Show member pathways
 12.89 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
10
CCR5 Pathway in Macrophages 65
Show member pathways
 12.86 CCR5 CCR8 CD247 CXCR2 CXCR3
11
Pathways in cancer 38
12.82 BMP4 IL2RA IL2RB STAT4 TGFB1
12
Immune response NFAT in immune response 23
Show member pathways
 12.66 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
13
NF-kappaB Signaling 4
12.6 IL2RA IL2RB PTPN2 PTPN22 STAT4 TNF
14
Interferon gamma signaling 67
Show member pathways
 12.56 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN2
15
T cell receptor signaling pathway 38
Show member pathways
 12.53 CCR5 CD247 TGFB1 TNF
16
ICos-ICosL Pathway in T-Helper Cell 65
Show member pathways
 12.43 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
17
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.42 CCR5 IL2RA IL2RB PTPN2 STAT4
18
TCR signaling (REACTOME) 67
Show member pathways
 12.39 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
19
Endocytosis 38
12.38 CCR5 CXCR2 IL2RA IL2RB
20
CD28 co-stimulation 67
Show member pathways
 12.25 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
21
Tuberculosis 38
12.25 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
22
Phagosome 38
12.16 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
23
Toxoplasmosis 38
Show member pathways
 12.14 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1
24
Cell adhesion molecules (CAMs) 38
12.13 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
25
Adipogenesis 1
12.08 BMP4 MIF TGFB1 TNF
26
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 12.01 CCR5 CCR8 CXCR2 CXCR3
27
IL12-mediated signaling events 1
Show member pathways
 11.99 CCR5 CD247 HLA-DRB1 IL2RA IL2RB STAT4
28
G-protein signaling N-RAS regulation pathway 23
Show member pathways
 11.98 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
29
S-1P Stimulated Signaling 65
11.97 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
30
MHC class II antigen presentation 67
11.95 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
31
Translocation of ZAP-70 to Immunological synapse 67
Show member pathways
 11.95 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
32
Human T-cell leukemia virus 1 infection 38
11.95 CREM HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
33
Jak-Stat Signaling Pathway (sino) 68
11.9 CCR5 IL2RA IL2RB STAT4
34
GPCRs, Other 1
11.89 CCR5 CXCR2 CXCR3
35
Th17 cell differentiation 38
Show member pathways
 11.86 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
36
TGF-beta signaling pathway (KEGG) 38
11.84 BMP4 TGFB1 TNF
37
Innate Lymphoid Cell Differentiation Pathways 66
11.83 CXCR3 IL2RA IL2RB TNF
38
Hematopoietic cell lineage 38
11.83 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA TNF
39
CTLA4 Signaling 65
11.76 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
40
Staphylococcus aureus infection 38
11.73 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
41
Rheumatoid arthritis 38
11.69 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.66 CD247 IL2RA IL2RB STAT4 TNF
43
TGF-beta Receptor Signaling (WikiPathways) 1
11.62 BMP4 TGFB1 TNF
44
DNA damage_Role of Brca1 and Brca2 in DNA repair 23
11.58 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1
45
Th2 Differentiation Pathway 66
11.51 IL2RA IL2RB STAT4
46
Cytokines and Inflammatory Response 1
11.28 HLA-DRB1 TGFB1 TNF
47
IL12 signaling mediated by STAT4 1
11 CD247 HLA-DRB1 IL2RA STAT4 TGFB1
48
RXR and RAR heterodimerization with other nuclear receptor 1
10.84 TGFB1 TNF
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GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

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Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.84 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 endosome membrane GO:0010008 9.8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 trans-Golgi network membrane GO:0032588 9.76 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.73 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 ER to Golgi transport vesicle membrane GO:0012507 9.71 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 transport vesicle membrane GO:0030658 9.67 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.62 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.56 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 external side of plasma membrane GO:0009897 9.56 CCR5 CCR8 CXCR2 CXCR3 HLA-DRB1 IL2RA
10 MHC class II protein complex GO:0042613 9.46 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 cell surface GO:0009986 9.32 CCR5 CXCR2 CXCR3 HLA-DPB1 HLA-DRB1 IL2RA
12 integral component of membrane GO:0016021 10.32 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DPB1
13 plasma membrane GO:0005886 10.32 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DPB1
14 integral component of plasma membrane GO:0005887 10.07 CCR5 CCR8 CXCR2 CXCR3 HLA-DQA1 IL2RB

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 BMP4 MIF PTPN22 TGFB1 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 BMP4 MIF PTPN22 TGFB1 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.95 BMP4 MIF TGFB1 TNF
4 inflammatory response GO:0006954 9.95 CCR5 CXCR2 CXCR3 MIF TGFB1 TNF
5 immune system process GO:0002376 9.95 CD247 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA MIF
6 chemotaxis GO:0006935 9.93 CCR5 CCR8 CXCR2 CXCR3
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 CCR5 CCR8 CXCR2 CXCR3
8 MAPK cascade GO:0000165 9.92 CCR5 IL2RA IL2RB TGFB1 TNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 MIF TGFB1 TNF
10 cytokine-mediated signaling pathway GO:0019221 9.85 CCR5 IL2RA IL2RB STAT4 TGFB1 TNF
11 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.84 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 positive regulation of MAP kinase activity GO:0043406 9.83 MIF TGFB1 TNF
13 calcium-mediated signaling GO:0019722 9.81 CCR5 CCR8 CXCR2 CXCR3
14 negative regulation of T cell proliferation GO:0042130 9.8 HLA-DRB1 IL2RA TGFB1
15 cell chemotaxis GO:0060326 9.8 CCR5 CCR8 CXCR2 CXCR3
16 cell surface receptor signaling pathway GO:0007166 9.8 CCR5 CD247 CXCR2 CXCR3 IL2RA MIF
17 T cell differentiation GO:0030217 9.79 PTPN2 PTPN22 TGFB1
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 PTPN22 TGFB1 TNF
19 chemokine-mediated signaling pathway GO:0070098 9.76 CCR5 CCR8 CXCR2 CXCR3
20 interferon-gamma-mediated signaling pathway GO:0060333 9.73 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 negative regulation of myoblast differentiation GO:0045662 9.72 BMP4 TGFB1 TNF
22 dendritic cell chemotaxis GO:0002407 9.7 CCR5 CXCR2
23 regulation of regulatory T cell differentiation GO:0045589 9.7 IL2RA TGFB1
24 negative regulation of T cell activation GO:0050868 9.69 PTPN22 TGFB1
25 positive regulation of protein localization to cell surface GO:2000010 9.69 CD247 TNF
26 negative regulation of immune response GO:0050777 9.69 IL2RA TGFB1
27 inflammatory response to antigenic stimulus GO:0002437 9.68 HLA-DRB1 IL2RA
28 positive regulation of SMAD protein signal transduction GO:0060391 9.68 BMP4 TGFB1
29 interleukin-2-mediated signaling pathway GO:0038110 9.68 IL2RA IL2RB
30 positive regulation of vascular permeability GO:0043117 9.67 CXCR2 TGFB1
31 response to cholesterol GO:0070723 9.67 CCR5 TGFB1
32 negative regulation of lipid storage GO:0010888 9.67 PTPN2 TNF
33 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.66 BMP4 TGFB1
34 regulation of protein import into nucleus GO:0042306 9.66 BMP4 TGFB1
35 common-partner SMAD protein phosphorylation GO:0007182 9.65 BMP4 TGFB1
36 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.64 HLA-DQB1 HLA-DRB1
37 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.64 MIF TNF
38 T cell receptor signaling pathway GO:0050852 9.63 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
39 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.61 HLA-DQB1 HLA-DRB1
40 positive regulation of mononuclear cell migration GO:0071677 9.6 TGFB1 TNF
41 regulation of cartilage development GO:0061035 9.59 BMP4 TGFB1
42 regulation of leukocyte migration GO:0002685 9.58 CXCR3 PTPN22
43 regulation of pri-miRNA transcription by RNA polymerase II GO:1902893 9.58 BMP4 TGFB1
44 antigen processing and presentation GO:0019882 9.56 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
45 immune response GO:0006955 9.32 CCR5 CCR8 CXCR2 CXCR3 HLA-DPB1 HLA-DQA1
46 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.78 BMP4 MIF TGFB1 TNF
2 peptide antigen binding GO:0042605 9.62 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 chemokine binding GO:0019956 9.56 CCR5 CCR8 CXCR2 CXCR3
4 MHC class II receptor activity GO:0032395 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 C-X-C chemokine receptor activity GO:0016494 9.46 CXCR2 CXCR3
6 C-C chemokine binding GO:0019957 9.46 CCR5 CCR8 CXCR2 CXCR3
7 interleukin-2 binding GO:0019976 9.43 IL2RA IL2RB
8 interleukin-2 receptor activity GO:0004911 9.4 IL2RA IL2RB
9 C-C chemokine receptor activity GO:0016493 9.26 CCR5 CCR8 CXCR2 CXCR3
10 chemokine receptor activity GO:0004950 8.92 CCR5 CCR8 CXCR2 CXCR3
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Sources for Oligoarticular Juvenile Idiopathic Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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