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MCID: OLG020
MIFTS: 45

Oligoarticular Juvenile Idiopathic Arthritis

Categories: Bone diseases, Eye diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards integrated aliases for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 58 17 71
Juvenile Pauciarticular Chronic Arthritis 71
Pauciarticular Chronic Arthritis 58
Oligoarticular Jia 58

Characteristics:

Orphanet epidemiological data:

58
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Respiratory diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

ICD10 via Orphanet 33 M08.4
UMLS via Orphanet 72 C2931171
Orphanet 58 ORPHA85410
UMLS 71 C2931171 C3898105
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Summaries for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to uveitis and juvenile rheumatoid arthritis. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is ANKRD55 (Ankyrin Repeat Domain 55), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Abatacept and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and b cells, and related phenotypes are arthralgia and joint swelling

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Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

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Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.8 TNF IL2RA CXCR3 CCR5
2 juvenile rheumatoid arthritis 30.7 TNF STAT4 MIF IL2RB IL2RA HLA-DRB1
3 herpes zoster 30.5 TNF HLA-DRB1 CCR5
4 takayasu arteritis 30.4 TNF HLA-DRB1 HLA-DQA1 HLA-DPB1
5 optic neuritis 30.0 TNF HLA-DRB1 HLA-DQB1 HLA-DQA1 CXCR3 CCR5
6 arthritis 29.8 TNF TGFB1 STAT4 PTPN22 MIF HLA-DRB1
7 neuritis 29.7 TNF TGFB1 MIF HLA-DRB1 HLA-DQA1 CXCR3
8 pauciarticular chronic arthritis 11.5
9 iridocyclitis 10.5
10 juvenile arthritis 10.5
11 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
12 achalasia, familial esophageal 10.4 HLA-DQB1 HLA-DQA1
13 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
14 hypersomnia 10.4 HLA-DRB1 HLA-DQB1
15 plica syndrome 10.4
16 synovitis 10.4
17 narcolepsy 2 10.4 HLA-DRB1 HLA-DQB1
18 neonatal lupus erythematosus 10.4 HLA-DQA1 HLA-DPB1
19 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-DRB1 HLA-DQB1
20 recurrent respiratory papillomatosis 10.4 HLA-DRB1 HLA-DQB1
21 metal allergy 10.3 HLA-DRB1 HLA-DQB1
22 juvenile myasthenia gravis 10.3 TGFB1 HLA-DRB1
23 occupational asthma 10.3 HLA-DRB1 HLA-DQB1 HLA-DPB1
24 apple allergy 10.3 HLA-DRB1 HLA-DQB1 HLA-DPB1
25 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
26 autoimmune hepatitis type 1 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
27 focal epithelial hyperplasia 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
28 podoconiosis 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
29 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
30 psoriatic arthritis 10.3
31 arthropathy 10.3
32 pauciarticular onset juvenile idiopathic arthritis 10.3
33 acute disseminated encephalomyelitis 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
34 cervical dystonia 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
35 idiopathic nephrotic syndrome 10.3 HLA-DRB1 HLA-DQB1
36 shrimp allergy 10.3 HLA-DQB1 HLA-DQA1
37 idiopathic bronchiectasis 10.3 HLA-DRB1 HLA-DQB1 HLA-DQA1
38 nontuberculous mycobacterial lung disease 10.2 TNF HLA-DRB1
39 eosinophilia-myalgia syndrome 10.2 TGFB1 HLA-DRB1 HLA-DQA1
40 osteonecrosis of the jaw 10.2 TGFB1 HLA-DRB1 HLA-DQB1
41 autoimmune hepatitis 10.2 TNF HLA-DRB1 HLA-DQB1
42 allergic bronchopulmonary aspergillosis 10.2 HLA-DRB1 HLA-DQB1 CXCR3
43 systemic onset juvenile idiopathic arthritis 10.2 TNF MIF HLA-DRB1
44 rheumatoid vasculitis 10.2 TNF MIF HLA-DRB1
45 sympathetic ophthalmia 10.2 TNF HLA-DRB1 HLA-DQA1
46 alveolar echinococcosis 10.2 TNF HLA-DRB1 HLA-DQB1
47 histoplasmosis 10.2 TNF HLA-DRB1 HLA-DQA1
48 actinic prurigo 10.2 TNF HLA-DRB1
49 endometritis 10.2 TNF HLA-DQB1 HLA-DQA1
50 microscopic colitis 10.2 TNF HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis
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Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

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Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 joint swelling 58 31 hallmark (90%) Very frequent (99-80%) HP:0001386
3 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
4 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
5 juvenile rheumatoid arthritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0005681
6 antinuclear antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0003493
7 iridocyclitis 58 31 frequent (33%) Frequent (79-30%) HP:0001094

GenomeRNAi Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.5 CREM HLA-DQA1 IL2RA TGFB1
2 Decreased viability GR00381-A-1 9.5 HLA-DQB1
3 Decreased viability GR00381-A-3 9.5 HLA-DQB1
4 Decreased viability GR00386-A-1 9.5 CD247 CXCR2 HLA-DQA1 HLA-DRB1
5 Decreased viability GR00402-S-2 9.5 BMP4 CXCR3 HLA-DQB1 IL2RA TNF

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
2 hematopoietic system MP:0005397 10.2 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQA1
3 endocrine/exocrine gland MP:0005379 10.18 BMP4 CD247 CREM CXCR2 HLA-DQA1 HLA-DQB1
4 immune system MP:0005387 10.13 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DQA1
5 digestive/alimentary MP:0005381 10.01 BMP4 CCR5 HLA-DQB1 IL2RA PTPN2 PTPN22
6 liver/biliary system MP:0005370 9.81 BMP4 CCR5 CREM CXCR2 HLA-DQB1 IL2RB
7 mortality/aging MP:0010768 9.8 BMP4 CCR5 CD247 CREM CXCR2 CXCR3
8 respiratory system MP:0005388 9.32 BMP4 CCR5 CREM CXCR2 CXCR3 HLA-DQB1
Sources

Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

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Drugs for Oligoarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 3 332348-12-6 10237
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3 Anti-Inflammatory Agents Phase 3
4 Analgesics, Non-Narcotic Phase 3
5 Immunosuppressive Agents Phase 3
6 Gastrointestinal Agents Phase 3
7 Immunologic Factors Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 3
9 Antirheumatic Agents Phase 3
10 Analgesics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 2-Part Open-Label Study to Assess the Clinical Benefit and Long-Term Safety of Etanercept in Children and Adolescents With Extended Oligoarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, or Psoriatic Arthritis Completed NCT00962741 Phase 3 Etanercept
2 A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) Recruiting NCT03841357 Phase 3 Abatacept Injection
3 AN OPEN-LABEL EXTENSION STUDY TO ASSESS THE LONG-TERM SAFETY AND CLINICAL BENEFIT OF ETANERCEPT IN CHILDREN AND ADOLESCENTS WITH EXTENDED OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR PSORIATIC ARTHRITIS WHO WERE PREVIOUSLY ENROLLED IN PROTOCOL 0881A1-3338-WW(B1801014) Active, not recruiting NCT01421069 Phase 3 etanercept

Search NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

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Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

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Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

40
Eye, T Cells, B Cells, Endothelial
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Publications for Oligoarticular Juvenile Idiopathic Arthritis

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Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Prediction of inactive disease and relapse in oligoarticular juvenile idiopathic arthritis. 61
33050742 2020
2
Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis. 61
32787920 2020
3
Evaluation of ocular surface and meibomian glands in patients with uveitis related to oligoarticular juvenile idiopathic arthritis. 61
32270334 2020
4
Tumefactive synovial thickening mimicking synovial chondromatosis in the setting of oligoarticular juvenile idiopathic arthritis in a toddler. 61
31890072 2020
5
A clinical score to guide in decision making for monogenic type I IFNopathies. 61
31641281 2020
6
Direct Healthcare Costs Associated with Oligoarticular Juvenile Idiopathic Arthritis at a Single Center. 61
32952562 2020
7
Benign transient hyperphosphatasemia in Juvenile Idiopathic Arthritis: a case report. 61
32281964 2019
8
Rice Bodies in a Patient with Oligoarticular Juvenile Idiopathic Arthritis. 61
31474614 2019
9
Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections. 61
31299977 2019
10
Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial. 61
31122296 2019
11
Intra-articular joint injections in juvenile idiopathic arthritis: state of the art. 61
30243614 2019
12
Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis. 61
30930898 2019
13
A novel mutation in NCF2 resulting in very-early-onset colitis and juvenile idiopathic arthritis in a patient with chronic granulomatous disease. 61
31832070 2019
14
Lyme Arthritis in Children on the Uptick in Western New York Area. 61
31819695 2019
15
Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis. 61
29025853 2018
16
The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. 61
29925386 2018
17
Low synovial double negative T and γδ T cells predict longer free-disease survival in oligoarticular JIA. 61
29059705 2018
18
Takayasu arteritis with an initial presentation of chronic monoarthritis mimicking oligoarticular juvenile idiopathic arthritis. 61
30069294 2018
19
Juvenile idiopathic arthritis in a patient with previous diagnosis of severe congenital lupus. 61
28649905 2018
20
Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable. 61
29310668 2018
21
The DNA methylation landscape of CD4+ T cells in oligoarticular juvenile idiopathic arthritis. 61
28969936 2018
22
Juvenile Idiopathic Arthritis. 61
28418334 2017
23
Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship? 61
28052441 2017
24
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial. 61
28162781 2017
25
Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. 61
28086918 2017
26
SUBRETINAL CANNULATION AS A COMPLICATION OF SUTURE TRABECULOTOMY SURGERY IN A PEDIATRIC PATIENT. 61
26967964 2017
27
Sleep Fragmentation and Biomarkers in Juvenile Idiopathic Arthritis. 61
26512051 2016
28
Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. 61
24131380 2014
29
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. 61
23696632 2014
30
The role of transforming growth factor β signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor β signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. 61
24782191 2014
31
Re: oligoarticular juvenile idiopathic arthritis among Saudi children. 61
24894793 2014
32
Serum TNF-α levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. 61
24839823 2014
33
Oligoarticular juvenile idiopathic arthritis among Saudi children. 61
24413854 2013
34
Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register. 61
23267169 2013
35
Disease activity and fatigue in juvenile idiopathic arthritis. 61
22807336 2013
36
Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis. 61
21647665 2012
37
Timing of uveitis onset in oligoarticular juvenile idiopathic arthritis (JIA) is the main predictor of severe course uveitis. 61
20039849 2012
38
Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation. 61
21621220 2011
39
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. 61
21962036 2011
40
Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. 61
21813070 2011
41
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. 61
21707991 2011
42
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. 61
21385553 2011
43
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. 61
20352219 2010
44
Oligoclonal expansion of T cells in persistent oligoarticular juvenile idiopathic arthritis. 61
20659414 2010
45
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study. 61
20403210 2010
46
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. 61
20127724 2010
47
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. 61
19933594 2010
48
HLA-DQA1 gene expression profiling in oligoarticular JIA. 61
19811310 2009
49
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. 61
19804628 2009
50
CXCR6-CXCL16 interaction in the pathogenesis of Juvenile Idiopathic Arthritis. 61
18760678 2008
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Variations for Oligoarticular Juvenile Idiopathic Arthritis

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Expression for Oligoarticular Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.
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Pathways for Oligoarticular Juvenile Idiopathic Arthritis

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Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.05 TNF TGFB1 PTPN22 PTPN2 MIF IL2RB
2
ERK Signaling 63
Show member pathways
 13.85 TNF TGFB1 STAT4 IL2RB IL2RA CXCR3
3
PEDF Induced Signaling 63
Show member pathways
 13.7 TNF TGFB1 MIF IL2RB IL2RA CXCR3
4
Akt Signaling 63
Show member pathways
 13.4 TNF TGFB1 STAT4 IL2RB IL2RA CXCR3
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.38 TNF TGFB1 PTPN2 IL2RB IL2RA HLA-DRB1
6
PAK Pathway 63
Show member pathways
 13.24 TNF TGFB1 PTPN22 PTPN2 IL2RB IL2RA
7
IL-2 Pathway 63
Show member pathways
 13.21 TNF STAT4 IL2RB IL2RA HLA-DRB1 HLA-DQB1
8
Allograft rejection 36 1
Show member pathways
 12.88 TNF TGFB1 IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
9
CCR5 Pathway in Macrophages 63
Show member pathways
 12.86 CXCR3 CXCR2 CD247 CCR8 CCR5
10
Measles 36
Show member pathways
 12.86 TNF IL2RB IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
11
Pathways in cancer 36
12.82 TGFB1 STAT4 IL2RB IL2RA BMP4
12
Herpes simplex virus 1 infection 36
12.79 TNF HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
13
Immune response NFAT in immune response 23
Show member pathways
 12.69 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
14
NF-kappaB Signaling 4
12.62 TNF STAT4 PTPN22 PTPN2 IL2RB IL2RA
15
Interferon gamma signaling 65
Show member pathways
 12.55 PTPN2 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
16
ICos-ICosL Pathway in T-Helper Cell 63
Show member pathways
 12.46 IL2RB IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 CD247
17
TCR signaling (REACTOME) 65
Show member pathways
 12.42 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
18
Endocytosis 36
12.4 IL2RB IL2RA CXCR2 CCR5
19
JAK-STAT signaling pathway 36
Show member pathways
 12.39 STAT4 PTPN2 IL2RB IL2RA
20
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 TNF IL2RB IL2RA CXCR3 CXCR2 CCR8
21
Tuberculosis 36
12.3 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
22
CD28 co-stimulation 65
Show member pathways
 12.27 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
23
Phagosome 36
12.15 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
24
Cell adhesion molecules 36
12.14 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
25
Adipogenesis 1
12.08 TNF TGFB1 MIF BMP4
26
Toxoplasmosis 36
Show member pathways
 12.08 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
27
IL12-mediated signaling events 1
Show member pathways
 12.02 STAT4 IL2RB IL2RA HLA-DRB1 CD247 CCR5
28
S-1P Stimulated Signaling 63
12 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
29
Translocation of ZAP-70 to Immunological synapse 65
Show member pathways
 11.99 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
30
MHC class II antigen presentation 65
11.96 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
31
Staphylococcus aureus infection 36
11.93 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
32
Human T-cell leukemia virus 1 infection 36
11.9 TNF TGFB1 IL2RB IL2RA HLA-DRB1 HLA-DQB1
33
GPCRs, Other 1
11.89 CXCR3 CXCR2 CCR5
34
Hematopoietic cell lineage 36
11.88 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
35
Th17 cell differentiation 36
Show member pathways
 11.86 TNF TGFB1 STAT4 IL2RB IL2RA HLA-DRB1
36
TGF-beta signaling pathway (KEGG) 36
11.85 TNF TGFB1 BMP4
37
Innate Lymphoid Cell Differentiation Pathways 64
11.85 TNF IL2RB IL2RA CXCR3
38
CTLA4 Signaling 63
11.81 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD247
39
Rheumatoid arthritis 36
11.77 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
40
Th1 Differentiation Pathway 64
Show member pathways
 11.74 TNF TGFB1 STAT4
41
G-protein signaling N-RAS regulation pathway 23
Show member pathways
 11.73 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
42
Commom Cytokine Receptor G Chain Siganaling Pathway 66
11.72 STAT4 IL2RB IL2RA
43
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.71 TNF STAT4 IL2RB IL2RA CD247
44
IgA-Producing B Cells in the Intestine 64
11.68 TNF TGFB1 IL2RA
45
TGF-beta Receptor Signaling (WikiPathways) 1
11.62 TNF TGFB1 BMP4
46
Th2 Differentiation Pathway 64
11.51 STAT4 IL2RB IL2RA
47
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.46 TNF TGFB1 IL2RB IL2RA
48
Cytokines and Inflammatory Response 1
11.29 TNF TGFB1 HLA-DRB1
49
IL12 signaling mediated by STAT4 1
11 TGFB1 STAT4 IL2RA HLA-DRB1 CD247
50
RXR and RAR heterodimerization with other nuclear receptor 1
10.85 TNF TGFB1
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GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

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Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.35 TNF PTPN2 IL2RB IL2RA HLA-DRB1 HLA-DQB1
2 plasma membrane GO:0005886 10.31 TNF TGFB1 PTPN2 MIF IL2RB IL2RA
3 integral component of plasma membrane GO:0005887 10.11 TNF IL2RB HLA-DRB1 HLA-DQA1 CXCR3 CXCR2
4 endosome GO:0005768 10 IL2RB HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CCR5
5 endosome membrane GO:0010008 9.85 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
6 trans-Golgi network membrane GO:0032588 9.78 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
7 endocytic vesicle membrane GO:0030666 9.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
8 ER to Golgi transport vesicle membrane GO:0012507 9.71 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
9 transport vesicle membrane GO:0030658 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.56 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
12 external side of plasma membrane GO:0009897 9.56 TNF IL2RB IL2RA HLA-DRB1 CXCR3 CXCR2
13 interleukin-2 receptor complex GO:0005893 9.49 IL2RB IL2RA
14 MHC class II protein complex GO:0042613 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
15 cell surface GO:0009986 9.32 TNF TGFB1 MIF IL2RB IL2RA HLA-DRB1

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 STAT4 IL2RB HLA-DRB1 CXCR3 CXCR2 CREM
2 adaptive immune response GO:0002250 10.07 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
3 immune system process GO:0002376 10.03 PTPN22 MIF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
4 negative regulation of gene expression GO:0010629 9.99 TNF TGFB1 PTPN22 MIF BMP4
5 positive regulation of protein phosphorylation GO:0001934 9.96 TNF TGFB1 HLA-DRB1 BMP4
6 MAPK cascade GO:0000165 9.96 TNF TGFB1 IL2RB IL2RA CCR5
7 cell surface receptor signaling pathway GO:0007166 9.93 MIF IL2RA CXCR3 CXCR2 CD247 CCR5
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 CXCR3 CXCR2 CCR8 CCR5
9 chemotaxis GO:0006935 9.92 CXCR3 CXCR2 CCR8 CCR5
10 cytokine-mediated signaling pathway GO:0019221 9.88 TNF TGFB1 STAT4 IL2RB IL2RA CCR5
11 inflammatory response GO:0006954 9.87 TNF TGFB1 MIF IL2RA CXCR3 CXCR2
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.86 TNF TGFB1 MIF
13 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.85 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
14 positive regulation of interferon-gamma production GO:0032729 9.83 TNF PTPN22 HLA-DPB1
15 cell chemotaxis GO:0060326 9.83 CXCR3 CXCR2 CCR8 CCR5
16 calcium-mediated signaling GO:0019722 9.81 CXCR3 CXCR2 CCR8 CCR5
17 chemokine-mediated signaling pathway GO:0070098 9.8 CXCR3 CXCR2 CCR8 CCR5
18 negative regulation of T cell proliferation GO:0042130 9.79 TGFB1 IL2RA HLA-DRB1
19 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.78 TNF TGFB1 BMP4
20 interferon-gamma-mediated signaling pathway GO:0060333 9.78 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
21 T cell differentiation GO:0030217 9.77 TGFB1 PTPN22 PTPN2
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 TNF TGFB1 PTPN22
23 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 TNF TGFB1 PTPN22 MIF HLA-DRB1 BMP4
24 negative regulation of myoblast differentiation GO:0045662 9.71 TNF TGFB1 BMP4
25 negative regulation of immune response GO:0050777 9.69 TGFB1 IL2RA
26 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TGFB1 BMP4
27 response to cholesterol GO:0070723 9.68 TGFB1 CCR5
28 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TNF TGFB1
29 interleukin-2-mediated signaling pathway GO:0038110 9.67 IL2RB IL2RA
30 regulation of protein import into nucleus GO:0042306 9.67 TGFB1 BMP4
31 antigen processing and presentation GO:0019882 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
32 negative regulation of lipid storage GO:0010888 9.66 TNF PTPN2
33 positive regulation of mononuclear cell migration GO:0071677 9.65 TNF TGFB1
34 common-partner SMAD protein phosphorylation GO:0007182 9.65 TGFB1 BMP4
35 regulation of leukocyte migration GO:0002685 9.64 PTPN22 CXCR3
36 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.64 HLA-DRB1 HLA-DQB1
37 regulation of cartilage development GO:0061035 9.63 TGFB1 BMP4
38 T cell receptor signaling pathway GO:0050852 9.63 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1 CD247
39 regulation of pri-miRNA transcription by RNA polymerase II GO:1902893 9.58 TGFB1 BMP4
40 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.58 HLA-DRB1 HLA-DQB1
41 immune response GO:0006955 9.32 TNF IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
42 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.47 TNF TGFB1 STAT4 PTPN22 PTPN2 MIF
2 cytokine activity GO:0005125 9.78 TNF TGFB1 MIF BMP4
3 chemokine receptor activity GO:0004950 9.5 CXCR3 CCR8 CCR5
4 non-membrane spanning protein tyrosine phosphatase activity GO:0004726 9.46 PTPN22 PTPN2
5 peptide antigen binding GO:0042605 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPB1
6 C-X-C chemokine receptor activity GO:0016494 9.43 CXCR3 CXCR2
7 MHC class II receptor activity GO:0032395 9.43 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 interleukin-2 binding GO:0019976 9.4 IL2RB IL2RA
9 interleukin-2 receptor activity GO:0004911 9.37 IL2RB IL2RA
10 C-C chemokine binding GO:0019957 9.26 CXCR3 CXCR2 CCR8 CCR5
11 C-C chemokine receptor activity GO:0016493 8.92 CXCR3 CXCR2 CCR8 CCR5
Sources

Sources for Oligoarticular Juvenile Idiopathic Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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