MCID: OLG020
MIFTS: 51

Oligoarticular Juvenile Idiopathic Arthritis

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 59 73
Juvenile Pauciarticular Chronic Arthritis 73
Pauciarticular Chronic Arthritis 59
Oligoarticular Jia 59

Characteristics:

Orphanet epidemiological data:

59
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA85410
ICD10 via Orphanet 34 M08.4
UMLS via Orphanet 74 C2931171

Summaries for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to uveitis and arthritis. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is CD247 (CD247 Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and t cells, and related phenotypes are joint swelling and arthralgia

Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.3 CXCR3 IL2RA TNF
2 arthritis 29.2 HLA-DQB1 HLA-DRB1 MIF PTPN22 STAT4 TNF
3 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 12.3
4 oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies 12.3
5 pauciarticular chronic arthritis 12.3
6 limbic encephalitis with lgi1 antibodies 11.0 HLA-DQB1 HLA-DRB1
7 metal allergy 10.8 HLA-DQB1 HLA-DRB1
8 hypersomnia 10.8 HLA-DQB1 HLA-DRB1
9 lichen planopilaris 10.8 HLA-DQB1 HLA-DRB1
10 juvenile myasthenia gravis 10.8 HLA-DRB1 TGFB1
11 achalasia, familial esophageal 10.8 HLA-DQA1 HLA-DQB1
12 microscopic polyangiitis 10.7 HLA-DRB1 TNF
13 type ii mixed cryoglobulinemia 10.7 HLA-DQB1 HLA-DRB1
14 autoimmune pancreatitis 10.7 HLA-DQB1 HLA-DRB1 TNF
15 lichen sclerosus 10.7 HLA-DQB1 HLA-DRB1 TNF
16 panuveitis 10.7 HLA-DQB1 HLA-DRB1 TNF
17 cytomegalovirus retinitis 10.7 CCR5 HLA-DQB1 TNF
18 geographic tongue 10.7 HLA-DQB1 HLA-DRB1 TNF
19 severe hemophilia a 10.7 HLA-DQB1 HLA-DRB1 TNF
20 focal epithelial hyperplasia 10.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 orofacial granulomatosis 10.6 CCR5 CXCR3 TNF
22 recurrent respiratory papillomatosis 10.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 rheumatoid vasculitis 10.6 HLA-DRB1 MIF TNF
24 optic neuritis 10.6 CCR5 HLA-DRB1 TNF
25 idiopathic bronchiectasis 10.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
26 berylliosis 10.6 HLA-DPB1 HLA-DRB1
27 sympathetic ophthalmia 10.6 HLA-DQA1 HLA-DRB1 TNF
28 idiopathic inflammatory myopathy 10.6 HLA-DQA1 HLA-DRB1
29 endometritis 10.5 HLA-DQA1 HLA-DQB1 TNF
30 takayasu arteritis 10.5 HLA-DPB1 HLA-DRB1 TNF
31 pustulosis palmaris et plantaris 10.5 CXCR3 TGFB1 TNF
32 eosinophilia-myalgia syndrome 10.5 HLA-DQA1 HLA-DRB1 TGFB1
33 neonatal lupus erythematosus 10.5 HLA-DPB1 HLA-DQA1
34 chronic beryllium disease 10.5 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
35 rubella 10.4 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
36 graft-versus-host disease 10.4 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
37 skin conditions 10.4 CD247 TNF
38 chagas disease 10.4 CCR5 TGFB1 TNF
39 intermediate uveitis 10.4 CXCR3 IL2RA TNF
40 leishmaniasis 10.3 HLA-DQA1 HLA-DQB1 HLA-DRB1 TNF
41 toxoplasmosis 10.3 CCR5 HLA-DQA1 HLA-DQB1 TNF
42 ocular cicatricial pemphigoid 10.3 HLA-DQB1 HLA-DRB1 MIF TGFB1
43 membranous nephropathy 10.3 HLA-DQA1 TGFB1 TNF
44 rheumatic disease 10.3 HLA-DRB1 IL2RA TNF
45 ileocolitis 10.3 IL2RA TNF
46 rheumatoid arthritis, systemic juvenile 10.3 HLA-DRB1 IL2RB MIF
47 rheumatic heart disease 10.3 HLA-DQA1 HLA-DRB1 TGFB1 TNF
48 connective tissue disease 10.2 HLA-DPB1 HLA-DQA1 HLA-DRB1 TNF
49 pulmonary disease, chronic obstructive 10.2 CXCR2 CXCR3 TGFB1 TNF
50 mycobacterium tuberculosis 1 10.2 CXCR2 CXCR3 TNF

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

59 32 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
2 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
3 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
4 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
5 antinuclear antibody positivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0003493
6 iridocyclitis 59 32 frequent (33%) Frequent (79-30%) HP:0001094
7 juvenile rheumatoid arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0005681

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQA1
2 cellular MP:0005384 10.24 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQB1
3 immune system MP:0005387 10.24 HLA-DQB1 IL2RA IL2RB MIF PTPN2 PTPN22
4 endocrine/exocrine gland MP:0005379 10.23 BMP4 CD247 CXCR2 HLA-DQA1 HLA-DQB1 IL2RA
5 homeostasis/metabolism MP:0005376 10.18 BMP4 CCR5 CXCR2 CXCR3 HLA-DQB1 IL2RA
6 digestive/alimentary MP:0005381 10.08 BMP4 CCR5 HLA-DQB1 IL2RA PTPN2 PTPN22
7 mortality/aging MP:0010768 10.07 TGFB1 TNF BMP4 CCR5 CD247 CXCR2
8 liver/biliary system MP:0005370 9.92 TNF BMP4 CCR5 CXCR2 HLA-DQB1 IL2RB
9 neoplasm MP:0002006 9.63 CCR5 CXCR2 CXCR3 MIF TGFB1 TNF
10 renal/urinary system MP:0005367 9.5 HLA-DQB1 PTPN22 STAT4 TGFB1 BMP4 CXCR2
11 respiratory system MP:0005388 9.23 TGFB1 TNF BMP4 CXCR2 CXCR3 HLA-DQB1

Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

Drugs for Oligoarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Not Applicable
2 Immunoglobulins Phase 4,Not Applicable
3 Vaccines Phase 4
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5 Analgesics Phase 3
6 Gastrointestinal Agents Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Immunosuppressive Agents Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12 Antirheumatic Agents Phase 3
13 Antibodies, Antinuclear Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Active, not recruiting NCT00573651 Phase 4
2 Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed NCT00962741 Phase 3 Etanercept
3 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Active, not recruiting NCT01421069 Phase 3 etanercept
4 Biomarkers in Idiopathic Juvenile Arthritis Unknown status NCT02343770 Not Applicable
5 Juvenile Arthritis Quantitative Imaging Recruiting NCT02684695

Search NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

41
Bone, Eye, T Cells, B Cells

Publications for Oligoarticular Juvenile Idiopathic Arthritis

Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show all 29)
# Title Authors Year
1
The DNA methylation landscape of CD4<sup>+</sup>T cells in oligoarticular juvenile idiopathic arthritis. ( 28969936 )
2018
2
The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. ( 29925386 )
2018
3
Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship? ( 28052441 )
2017
4
Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis. ( 29025853 )
2017
5
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial. ( 28162781 )
2017
6
Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. ( 28086918 )
2017
7
The role of transforming growth factor I^ signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor I^ signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. ( 24782191 )
2014
8
Re: oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24894793 )
2014
9
Serum TNF-I+ levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. ( 24839823 )
2014
10
Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis. ( 24131380 )
2013
11
Oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24413854 )
2013
12
Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register. ( 23267169 )
2013
13
The role of TGFI^ signaling in fibroblast-like synoviocytes from oligoarticular juvenile idiopathic arthritis. ( 24375380 )
2013
14
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. ( 23696632 )
2013
15
Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis. ( 21647665 )
2012
16
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. ( 21707991 )
2011
17
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. ( 21962036 )
2011
18
Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation. ( 21621220 )
2011
19
Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. ( 21813070 )
2011
20
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. ( 21385553 )
2011
21
Oligoclonal expansion of T cells in persistent oligoarticular juvenile idiopathic arthritis. ( 20659414 )
2010
22
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. ( 20352219 )
2010
23
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study. ( 20403210 )
2010
24
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. ( 20127724 )
2010
25
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. ( 19933594 )
2010
26
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. ( 19804628 )
2009
27
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. ( 18078632 )
2007
28
The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. ( 15703957 )
2006
29
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. ( 11371669 )
2001

Variations for Oligoarticular Juvenile Idiopathic Arthritis

Expression for Oligoarticular Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.

Pathways for Oligoarticular Juvenile Idiopathic Arthritis

Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCR5 CD247 CXCR2 HLA-DPB1 HLA-DQA1 HLA-DQB1
2
Show member pathways
13.86 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
3
Show member pathways
13.69 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
4
Show member pathways
13.38 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
5
Show member pathways
13.36 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
6
Show member pathways
13.24 BMP4 CCR5 CCR8 CXCR2 CXCR3 IL2RA
7
Show member pathways
12.9 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
8
Show member pathways
12.85 CCR5 CCR8 CD247 CXCR2 CXCR3
9
Show member pathways
12.82 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
10 12.81 BMP4 IL2RA IL2RB STAT4 TGFB1
11
Show member pathways
12.65 IL2RA IL2RB PTPN2 STAT4 TNF
12 12.61 IL2RA IL2RB PTPN2 PTPN22 STAT4 TNF
13
Show member pathways
12.59 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
14
Show member pathways
12.58 CCR5 CCR8 STAT4 TGFB1 TNF
15
Show member pathways
12.55 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN2
16
Show member pathways
12.43 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
17
Show member pathways
12.4 CCR5 CD247 TGFB1 TNF
18
Show member pathways
12.39 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
19 12.38 CCR5 CXCR2 IL2RA IL2RB
20 12.29 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 12.27 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
22
Show member pathways
12.26 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
23
Show member pathways
12.18 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1
24 12.16 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 12.16 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
26 12.13 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
27 12.08 BMP4 MIF TGFB1 TNF
28
Show member pathways
12.01 CCR5 CCR8 CXCR2 CXCR3
29
Show member pathways
12.01 CCR5 CD247 HLA-DRB1 IL2RA IL2RB STAT4
30 11.97 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
31
Show member pathways
11.97 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
32 11.95 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
33 11.92 CCR5 IL2RA IL2RB STAT4
34 11.89 CCR5 CXCR2 CXCR3
35 11.87 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA TNF
36 11.83 CXCR3 IL2RA IL2RB TNF
37 11.79 BMP4 TGFB1 TNF
38
Show member pathways
11.79 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
39 11.77 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
40 11.75 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
41
Show member pathways
11.74 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
42
Show member pathways
11.69 CD247 IL2RA IL2RB STAT4 TNF
43 11.65 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
44 11.62 BMP4 TGFB1 TNF
45 11.52 IL2RA IL2RB STAT4
46 11.3 HLA-DRB1 TGFB1 TNF
47 11.1 CD247 HLA-DRB1 IL2RA STAT4 TGFB1
48 10.85 TGFB1 TNF

GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.95 CCR5 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RB
2 lysosomal membrane GO:0005765 9.84 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 endosome membrane GO:0010008 9.8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 external side of plasma membrane GO:0009897 9.8 CCR5 CXCR3 HLA-DRB1 IL2RA IL2RB TNF
5 trans-Golgi network membrane GO:0032588 9.76 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 endocytic vesicle membrane GO:0030666 9.73 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.71 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 transport vesicle membrane GO:0030658 9.67 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.46 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 cell surface GO:0009986 9.28 CCR5 CXCR2 CXCR3 HLA-DPB1 HLA-DRB1 IL2RA
12 MHC class II protein complex GO:0042613 9.26 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 integral component of membrane GO:0016021 10.32 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DPB1
14 plasma membrane GO:0005886 10.32 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DPB1
15 integral component of plasma membrane GO:0005887 10.07 CCR5 CCR8 CXCR2 CXCR3 HLA-DQA1 IL2RB

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.96 CCR5 IL2RA IL2RB TGFB1 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 BMP4 MIF PTPN22 TGFB1 TNF
3 chemotaxis GO:0006935 9.94 CCR5 CCR8 CXCR2 CXCR3
4 positive regulation of protein phosphorylation GO:0001934 9.93 BMP4 MIF TGFB1 TNF
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 CCR5 CCR8 CXCR2 CXCR3
6 negative regulation of gene expression GO:0010629 9.91 BMP4 MIF PTPN22 TGFB1 TNF
7 cytokine-mediated signaling pathway GO:0019221 9.91 CCR5 IL2RA IL2RB STAT4 TGFB1 TNF
8 cell surface receptor signaling pathway GO:0007166 9.88 CCR5 CD247 CXCR2 CXCR3 IL2RA MIF
9 inflammatory response GO:0006954 9.87 CCR5 CXCR2 CXCR3 IL2RA MIF TGFB1
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 MIF TGFB1 TNF
11 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.84 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 positive regulation of MAP kinase activity GO:0043406 9.83 MIF TGFB1 TNF
13 chemokine-mediated signaling pathway GO:0070098 9.8 CCR5 CCR8 CXCR2 CXCR3
14 negative regulation of T cell proliferation GO:0042130 9.79 HLA-DRB1 IL2RA TGFB1
15 T cell differentiation GO:0030217 9.79 PTPN2 PTPN22 TGFB1
16 interferon-gamma-mediated signaling pathway GO:0060333 9.78 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 PTPN22 TGFB1 TNF
18 T cell receptor signaling pathway GO:0050852 9.73 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
19 negative regulation of myoblast differentiation GO:0045662 9.7 BMP4 TGFB1 TNF
20 dendritic cell chemotaxis GO:0002407 9.69 CCR5 CXCR2
21 regulation of regulatory T cell differentiation GO:0045589 9.69 IL2RA TGFB1
22 positive regulation of protein localization to cell surface GO:2000010 9.69 CD247 TNF
23 negative regulation of T cell activation GO:0050868 9.68 PTPN22 TGFB1
24 inflammatory response to antigenic stimulus GO:0002437 9.68 HLA-DRB1 IL2RA
25 positive regulation of SMAD protein signal transduction GO:0060391 9.68 BMP4 TGFB1
26 positive regulation of vascular permeability GO:0043117 9.67 CXCR2 TGFB1
27 interleukin-2-mediated signaling pathway GO:0038110 9.67 IL2RA IL2RB
28 response to cholesterol GO:0070723 9.67 CCR5 TGFB1
29 antigen processing and presentation GO:0019882 9.67 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
30 negative regulation of lipid storage GO:0010888 9.66 PTPN2 TNF
31 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.66 BMP4 TGFB1
32 regulation of protein import into nucleus GO:0042306 9.65 BMP4 TGFB1
33 common-partner SMAD protein phosphorylation GO:0007182 9.65 BMP4 TGFB1
34 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.64 MIF TNF
35 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.63 HLA-DQB1 HLA-DRB1
36 regulation of leukocyte migration GO:0002685 9.61 CXCR3 PTPN22
37 regulation of pri-miRNA transcription by RNA polymerase II GO:1902893 9.6 BMP4 TGFB1
38 regulation of cartilage development GO:0061035 9.59 BMP4 TGFB1
39 positive regulation of mononuclear cell migration GO:0071677 9.58 TGFB1 TNF
40 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.58 HLA-DQB1 HLA-DRB1
41 immune response GO:0006955 9.56 CCR5 CCR8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
42 T cell costimulation GO:0031295 9.55 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
43 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.92 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
44 immune system process GO:0002376 10 CD247 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA MIF

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 BMP4 MIF TGFB1 TNF
2 protein tyrosine kinase binding GO:1990782 9.48 CD247 PTPN22
3 C-C chemokine receptor activity GO:0016493 9.46 CCR5 CCR8
4 BMP receptor binding GO:0070700 9.43 BMP4 TGFB1
5 C-X-C chemokine receptor activity GO:0016494 9.37 CXCR2 CXCR3
6 MHC class II receptor activity GO:0032395 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 interleukin-2 binding GO:0019976 9.32 IL2RA IL2RB
8 interleukin-2 receptor activity GO:0004911 9.26 IL2RA IL2RB
9 peptide antigen binding GO:0042605 9.26 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 chemokine receptor activity GO:0004950 8.92 CCR5 CCR8 CXCR2 CXCR3

Sources for Oligoarticular Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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