OAT
MCID: OLG022
MIFTS: 36

Oligoasthenoteratozoospermia (OAT)

Categories: Reproductive diseases

Aliases & Classifications for Oligoasthenoteratozoospermia

MalaCards integrated aliases for Oligoasthenoteratozoospermia:

Name: Oligoasthenoteratozoospermia 12 15
Oligoasthenoteratospermia 12
Oat 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070311

Summaries for Oligoasthenoteratozoospermia

Disease Ontology : 12 A form of male infertility that is characterized by a combination of low number or oligozoospermia, poor motility or asthenozoospermia, and abnormal shape or teratozoospermia of sperms. OAT is the most common cause of male subfertility.

MalaCards based summary : Oligoasthenoteratozoospermia, also known as oligoasthenoteratospermia, is related to oligospermia and male infertility. An important gene associated with Oligoasthenoteratozoospermia is TDRD6 (Tudor Domain Containing 6), and among its related pathways/superpathways are Platinum drug resistance and Busulfan Pathway, Pharmacodynamics. The drugs Metformin and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testis and lung, and related phenotype is reproductive system.

Wikipedia : 76 Male infertility refers to a male''s inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Oligoasthenoteratozoospermia

Diseases related to Oligoasthenoteratozoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 oligospermia 31.7 AR GSTM1
2 male infertility 30.0 AR CATSPER1 DAZL
3 lung oat cell carcinoma 12.6
4 gyrate atrophy of choroid and retina 12.4
5 small cell cancer of the lung 11.7
6 norrie disease 11.5
7 esophagus small cell carcinoma 11.4
8 cystinuria 11.1
9 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 11.1
10 3-methylglutaconic aciduria, type v 11.1
11 ewing sarcoma 11.1
12 cerebral creatine deficiency syndrome 3 11.1
13 cerebral creatine deficiency syndrome 2 11.1
14 autoimmune optic neuritis 11.1
15 cerebral creatine deficiency syndrome 11.1
16 choroid disease 11.1
17 reye syndrome 11.1
18 uveal disease 11.1
19 rheumatic myocarditis 11.1
20 parapsoriasis 11.1
21 oral mucosa leukoplakia 11.1
22 ornithinemia 11.1
23 spermatogenic failure 12 11.1
24 spinal muscular atrophy, lower extremity-predominant, 2, autosomal dominant 11.1
25 extrahepatic bile duct small cell adenocarcinoma 11.0
26 gallbladder small cell carcinoma 11.0
27 prostate small cell carcinoma 11.0
28 celiac disease 1 10.4
29 azoospermia 10.4
30 infertility 10.3
31 dermatitis 10.2
32 alcoholic hepatitis 10.2
33 cardia cancer 10.1 GSTM1 GSTP1
34 diffuse gastric cancer 10.1 GSTM1 GSTP1
35 dermatitis herpetiformis, familial 10.1
36 dermatitis herpetiformis 10.1
37 carcinoid syndrome 10.1
38 xeroderma pigmentosum, complementation group d 10.1 GSTM1 GSTP1
39 asbestosis 10.1 GSTM1 GSTP1
40 hypogonadism 10.0
41 orchitis 10.0
42 varicocele 10.0
43 bowenoid papulosis 10.0
44 lung cancer 10.0
45 dermatitis, atopic 10.0
46 conn's syndrome 10.0
47 lactic acidosis 10.0
48 colorectal cancer 9.9
49 methane production 9.9
50 myeloma, multiple 9.9

Graphical network of the top 20 diseases related to Oligoasthenoteratozoospermia:



Diseases related to Oligoasthenoteratozoospermia

Symptoms & Phenotypes for Oligoasthenoteratozoospermia

MGI Mouse Phenotypes related to Oligoasthenoteratozoospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 AR BRWD1 CATSPER1 CSTF2T LRGUK TDRD6

Drugs & Therapeutics for Oligoasthenoteratozoospermia

Drugs for Oligoasthenoteratozoospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
3
Enclomiphene Investigational Phase 4,Phase 3 15690-57-0
4 Citrate Phase 4,Phase 3
5 Clomiphene Phase 4,Phase 3
6 insulin Phase 4,Not Applicable
7 Estrogen Antagonists Phase 4,Phase 3
8 Chorionic Gonadotropin Phase 4
9 Zuclomiphene Phase 4,Phase 3
10 Estrogen Receptor Antagonists Phase 4,Phase 3
11 Estrogen Receptor Modulators Phase 4,Phase 3
12 Fertility Agents Phase 4,Phase 3
13 Hormones Phase 4,Phase 3
14 Selective Estrogen Receptor Modulators Phase 4,Phase 3
15 Anticoagulants Phase 4,Phase 3
16 Estrogens Phase 4,Phase 3
17 Hormone Antagonists Phase 4,Phase 3
18 Insulin, Globin Zinc Phase 4,Not Applicable
19 Hypoglycemic Agents Phase 4,Not Applicable
20 Calcium, Dietary Phase 4,Phase 3,Phase 2
21 Chelating Agents Phase 4,Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
23
Testosterone enanthate Approved Phase 3 315-37-7 9416
24
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
25
Methyltestosterone Approved Phase 3 58-18-4 6010
26
Testosterone Approved, Investigational Phase 3 58-22-0 6013
27
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
28
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
29 Ginger Approved Phase 3
30 English walnut Approved Phase 2, Phase 3
31
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
32
Polyestradiol phosphate Approved Phase 3 28014-46-2
33 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
34
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
36 Testosterone 17 beta-cypionate Phase 3
37 Trace Elements Phase 2, Phase 3,Not Applicable
38 Micronutrients Phase 2, Phase 3,Not Applicable
39 Vitamins Phase 2, Phase 3,Not Applicable
40 Aromatase Inhibitors Phase 3
41 Steroid Synthesis Inhibitors Phase 3
42 Vitamin B9 Phase 2, Phase 3
43 Vitamin B Complex Phase 2, Phase 3
44 Hematinics Phase 2, Phase 3
45 Folate Phase 2, Phase 3
46 Sweet Basil Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Estradiol 17 beta-cypionate Phase 3
49 Androgens Phase 3
50 Estradiol 3-benzoate Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Unknown status NCT02998593 Phase 3 Bahman capsules;Placebo
5 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
6 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
7 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
8 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
9 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
10 Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Not yet recruiting NCT03615547 Phase 3 Clomifene Citrate
11 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
12 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
13 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
14 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
15 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
16 Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
17 Severe Male Factor Infertility Management Unknown status NCT02752555 Not Applicable
18 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173 Not Applicable
19 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
20 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584 Not Applicable
21 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799 Not Applicable
22 Preimplantation Genetic Screening in Patients With Male Factor Infertility Unknown status NCT02941965 Not Applicable
23 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
24 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482 Not Applicable
25 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588 Not Applicable
26 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
27 Genetic Studies Spermatogenic Failure Completed NCT00548977
28 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
29 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
30 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Not Applicable Mesenchymal stem cell injection
31 A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome Completed NCT03594201
32 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
33 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
34 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Recruiting NCT03497728
35 Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia Recruiting NCT03634644 Not Applicable Omega 3 fatty acid;Placebo oral capsule
36 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Recruiting NCT02932527 Not Applicable
37 Fertility Preservation in Cases of Klinefelter Syndrome. Active, not recruiting NCT01918280 Not Applicable
38 Serum and Semen Vitamin D Level With Semen Parameters Not yet recruiting NCT03477136
39 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Not Applicable Ramipril;Placebo

Search NIH Clinical Center for Oligoasthenoteratozoospermia

Genetic Tests for Oligoasthenoteratozoospermia

Anatomical Context for Oligoasthenoteratozoospermia

MalaCards organs/tissues related to Oligoasthenoteratozoospermia:

41
Bone, Testis, Lung, Liver, Heart, Prostate, Retina

Publications for Oligoasthenoteratozoospermia

Articles related to Oligoasthenoteratozoospermia:

(show top 50) (show all 60)
# Title Authors Year
1
TDRD6 is associated with oligoasthenoteratozoospermia by sequencing the patient from a consanguineous family. ( 29551503 )
2018
2
Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria. ( 29500854 )
2018
3
Sperm chromatin and DNA integrity, methyltransferase mRNA levels, and global DNA methylation in oligoasthenoteratozoospermia. ( 29662821 )
2018
4
The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. ( 29984205 )
2018
5
Increasing evidence of the role of the sperm epigenome in embryogenesis: oligoasthenoteratozoospermia, altered embryo DNA methylation, and miscarriage. ( 30098686 )
2018
6
The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia and immotile short tail sperm defects. ( 28138870 )
2017
7
Partial Deletions of Y-Chromosome in Infertile Men with Non-obstructive Azoospermia and Oligoasthenoteratozoospermia in a Turkish Population. ( 28438864 )
2017
8
Effect of modifiable lifestyle factors and antioxidant treatment on semen parameters of men with severe oligoasthenoteratozoospermia. ( 27859525 )
2017
9
Antioxidant therapy in idiopathic oligoasthenoteratozoospermia. ( 28717270 )
2017
10
The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study. ( 28245352 )
2017
11
Association of large scale 4977-bp "common" deletions in sperm mitochondrial DNA with asthenozoospermia and oligoasthenoteratozoospermia. ( 27110076 )
2016
12
Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and PycnogenolAr. ( 26428638 )
2015
13
Efficacy of tamoxifen and l-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia. ( 25274200 )
2015
14
Treatment strategies for severe oligoasthenoteratozoospermia (OAT) (<0.1 million/mL) patients. ( 26266459 )
2015
15
Pregnancy outcome after ICSI with thawed testicular sperm from men with non-obstructive azoospermia compared to ICSI with ejaculated sperm from men with severe oligoasthenoteratozoospermia and IVF with normal ejaculated sperm. ( 24303883 )
2014
16
Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia. ( 24550984 )
2014
17
Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. ( 24800224 )
2014
18
Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci. ( 25329700 )
2014
19
Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia. ( 25709639 )
2014
20
The role of hormones on semen parameters in patients with idiopathic or varicocele-related oligoasthenoteratozoospermia (OAT) syndrome. ( 23933342 )
2013
21
The association of seminal plasma antioxidant levels and sperm chromatin status with genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) in infertile men with oligoasthenoteratozoospermia. ( 23324581 )
2013
22
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. ( 23550190 )
2013
23
Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. ( 23052838 )
2013
24
Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers. ( 23628110 )
2013
25
Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. ( 23697839 )
2013
26
Density gradient centrifugation prior to cryopreservation and hypotaurine supplementation improve post-thaw quality of sperm from infertile men with oligoasthenoteratozoospermia. ( 23760160 )
2013
27
Recombinant human FSH reduces sperm DNA fragmentation in men with idiopathic oligoasthenoteratozoospermia. ( 21868752 )
2012
28
The effect of coenzyme Q₁₀ supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. ( 22081410 )
2012
29
A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress. ( 23716949 )
2012
30
A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. ( 20824894 )
2011
31
Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. ( 21399391 )
2011
32
A rare Y chromosome constitutional rearrangement: a partial AZFb deletion and duplication within chromosome Yp in an infertile man with severe oligoasthenoteratozoospermia. ( 21950337 )
2011
33
Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia : A double blind randomized placebo-controlled trial. ( 22022059 )
2011
34
Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. ( 21219381 )
2011
35
Activation of the immune system and sperm DNA fragmentation are associated with idiopathic oligoasthenoteratospermia in men with couple subfertility. ( 21704215 )
2011
36
Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified? ( 21716893 )
2011
37
Inositol activity in oligoasthenoteratospermia--an in vitro study. ( 21222378 )
2010
38
A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single aneuploidy and diploidy by five-color fluorescence in situ hybridization using one probe set. ( 18036525 )
2008
39
Correction of failed fertilization despite intracytoplasmic sperm injection with oligoasthenoteratozoospermia but with acrosomes present by oocyte activation with calcium ionophore--case report. ( 19205437 )
2008
40
A study to sustain the hypothesis of the multiple genesis of oligoasthenoteratospermia in human idiopathic infertile males. ( 18562708 )
2008
41
Analysis of the CAG repeat number in exon 1 of the androgen receptor gene in Slovene men with idiopathic azoospermia and oligoasthenoteratozoospermia. ( 17334597 )
2007
42
Male idiopathic oligoasthenoteratozoospermia. ( 16491265 )
2006
43
Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10). ( 17027368 )
2006
44
A mouse model of familial oligoasthenoteratozoospermia. ( 15705627 )
2005
45
Pathophysiology of oligoasthenoteratozoospermia: are we improving in the diagnosis? ( 14656405 )
2003
46
The value of sperm pooling and cryopreservation in patients with transient azoospermia or severe oligoasthenoteratozoospermia. ( 11756381 )
2002
47
Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression. ( 11821108 )
2002
48
Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology. ( 11134367 )
2001
49
Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermia. ( 11277880 )
2001
50
Semen sample collection in medium enhances the implantation rate following ICSI in patients with severe oligoasthenoteratozoospermia. ( 11387278 )
2001

Variations for Oligoasthenoteratozoospermia

Copy number variations for Oligoasthenoteratozoospermia from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 266850 Y 11300000 57772954 Microdeletion Oligoasthenoteratozoospermia

Expression for Oligoasthenoteratozoospermia

Search GEO for disease gene expression data for Oligoasthenoteratozoospermia.

Pathways for Oligoasthenoteratozoospermia

Pathways related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.12 GSTM1 GSTP1
2
Show member pathways
10.8 GSTM1 GSTP1
3 10.42 GSTM1 GSTP1
4 10 GSTM1 GSTP1

GO Terms for Oligoasthenoteratozoospermia

Biological processes related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.26 GSTM1 GSTP1
2 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.16 AR GSTP1
3 spermatogenesis GO:0007283 9.02 AR CATSPER1 DAZL LRGUK TDRD6
4 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM1 GSTP1

Molecular functions related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTP1
2 glutathione binding GO:0043295 8.62 GSTM1 GSTP1

Sources for Oligoasthenoteratozoospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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