OAT
MCID: OLG022
MIFTS: 36

Oligoasthenoteratozoospermia (OAT)

Categories: Reproductive diseases

Aliases & Classifications for Oligoasthenoteratozoospermia

MalaCards integrated aliases for Oligoasthenoteratozoospermia:

Name: Oligoasthenoteratozoospermia 12 15
Oligoasthenoteratospermia 12
Oat 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070311

Summaries for Oligoasthenoteratozoospermia

Disease Ontology : 12 A form of male infertility that is characterized by a combination of low number or oligozoospermia, poor motility or asthenozoospermia, and abnormal shape or teratozoospermia of sperms. OAT is the most common cause of male subfertility.

MalaCards based summary : Oligoasthenoteratozoospermia, also known as oligoasthenoteratospermia, is related to oligospermia and lung oat cell carcinoma. An important gene associated with Oligoasthenoteratozoospermia is TDRD6 (Tudor Domain Containing 6), and among its related pathways/superpathways are Platinum drug resistance and Busulfan Pathway, Pharmacodynamics. The drugs Metformin and Sodium Citrate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testis.

Wikipedia : 77 Male infertility refers to a male''s inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Oligoasthenoteratozoospermia

Diseases related to Oligoasthenoteratozoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 oligospermia 31.7 AR GSTM1
2 lung oat cell carcinoma 12.6
3 gyrate atrophy of choroid and retina 12.5
4 small cell cancer of the lung 11.7
5 norrie disease 11.5
6 esophagus small cell carcinoma 11.4
7 cystinuria 11.1
8 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 11.1
9 3-methylglutaconic aciduria, type v 11.1
10 cerebral creatine deficiency syndrome 3 11.1
11 cerebral creatine deficiency syndrome 2 11.1
12 autoimmune optic neuritis 11.1
13 cerebral creatine deficiency syndrome 11.1
14 bird fancier's lung 11.1
15 choroid disease 11.1
16 reye syndrome 11.1
17 uveal disease 11.1
18 rheumatic myocarditis 11.1
19 parapsoriasis 11.1
20 ornithinemia 11.1
21 spermatogenic failure 12 11.1
22 spinal muscular atrophy, lower extremity-predominant, 2a, childhood onset, autosomal dominant 11.1
23 extrahepatic bile duct small cell adenocarcinoma 11.1
24 gallbladder small cell carcinoma 11.1
25 prostate small cell carcinoma 11.1
26 celiac disease 1 10.4
27 azoospermia 10.4
28 bronchus cancer 10.4
29 infertility 10.4
30 dermatitis 10.2
31 male infertility 10.2
32 alcoholic hepatitis 10.2
33 cardia cancer 10.2 GSTM1 GSTP1
34 diffuse gastric cancer 10.2 GSTM1 GSTP1
35 xeroderma pigmentosum, complementation group d 10.1 GSTM1 GSTP1
36 dermatitis, atopic 10.1
37 asbestosis 10.1 GSTM1 GSTP1
38 hypogonadism 10.1
39 orchitis 10.1
40 dermatitis herpetiformis, familial 10.1
41 sclerosing cholangitis, neonatal 10.1
42 dermatitis herpetiformis 10.1
43 carcinoid syndrome 10.1
44 varicocele 10.1
45 bowenoid papulosis 10.1
46 multiple sclerosis 10.0
47 fish-eye disease 10.0
48 lung cancer 10.0
49 leukemia 10.0
50 small cell carcinoma 10.0

Graphical network of the top 20 diseases related to Oligoasthenoteratozoospermia:



Diseases related to Oligoasthenoteratozoospermia

Symptoms & Phenotypes for Oligoasthenoteratozoospermia

Drugs & Therapeutics for Oligoasthenoteratozoospermia

Drugs for Oligoasthenoteratozoospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Sodium Citrate Approved, Investigational Phase 4,Phase 3 68-04-2
3
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2 7440-70-2 271
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
5
Enclomiphene Investigational Phase 4,Phase 3 15690-57-0
6 Estrogen Receptor Modulators Phase 4,Phase 3
7 Anticoagulants Phase 4,Phase 3
8 Citrate Phase 4,Phase 3
9 Hormone Antagonists Phase 4,Phase 3,Phase 2
10 Clomiphene Phase 4,Phase 3
11 Estrogens Phase 4,Phase 3
12 Insulin, Globin Zinc Phase 4,Not Applicable
13 Fertility Agents Phase 4,Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
15 Chorionic Gonadotropin Phase 4
16 Hormones Phase 4,Phase 3,Phase 2
17 Estrogen Antagonists Phase 4,Phase 3
18 Calcium, Dietary Phase 4,Phase 3,Phase 2
19 Estrogen Receptor Antagonists Phase 4,Phase 3
20 Hypoglycemic Agents Phase 4,Not Applicable
21 insulin Phase 4,Not Applicable
22 Zuclomiphene Phase 4,Phase 3
23 Selective Estrogen Receptor Modulators Phase 4,Phase 3
24 Chelating Agents Phase 4,Phase 3
25
Testosterone enanthate Approved Phase 3 315-37-7 9416
26
Testosterone Approved, Experimental, Investigational Phase 3 58-22-0, 481-30-1 6013 10204
27
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
28
Methyltestosterone Approved Phase 3 58-18-4 6010
29
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
30
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
31
Polyestradiol phosphate Approved Phase 3 28014-46-2
32
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
33
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
34 English walnut Approved Phase 2, Phase 3
35 Ginger Approved Phase 3
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
37 Testosterone 17 beta-cypionate Phase 3
38 Nutrients Phase 2, Phase 3,Not Applicable
39 Vitamins Phase 2, Phase 3,Not Applicable
40 Micronutrients Phase 2, Phase 3,Not Applicable
41 Trace Elements Phase 2, Phase 3,Not Applicable
42 Aromatase Inhibitors Phase 3
43 Steroid Synthesis Inhibitors Phase 3
44 Estradiol 17 beta-cypionate Phase 3
45 Antineoplastic Agents, Hormonal Phase 3
46 Estradiol 3-benzoate Phase 3
47 Androgens Phase 3
48 Anabolic Agents Phase 3
49 Hematinics Phase 2, Phase 3
50 Folate Phase 2, Phase 3

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Unknown status NCT02998593 Phase 3 Bahman capsules;Placebo
5 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
6 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
7 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
8 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
9 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
10 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
11 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
12 Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Not yet recruiting NCT03615547 Phase 3 Clomifene Citrate
13 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
14 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
15 Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
16 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
17 Severe Male Factor Infertility Management Unknown status NCT02752555 Not Applicable
18 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173 Not Applicable
19 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
20 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584 Not Applicable
21 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799 Not Applicable
22 Preimplantation Genetic Screening in Patients With Male Factor Infertility Unknown status NCT02941965 Not Applicable
23 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
24 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482 Not Applicable
25 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Not Applicable Ramipril;Placebo
26 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588 Not Applicable
27 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
28 Is Oxidative Stress in Semen Reduced by Lifestyle Intervention Recruiting NCT03898752 Not Applicable
29 Genetic Studies Spermatogenic Failure Completed NCT00548977
30 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
31 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Recruiting NCT03497728
32 Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia Recruiting NCT03634644 Not Applicable Omega 3 fatty acid;Placebo oral capsule
33 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
34 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
35 Fertility Preservation in Cases of Klinefelter Syndrome. Active, not recruiting NCT01918280 Not Applicable
36 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Not Applicable Mesenchymal stem cell injection
37 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Recruiting NCT02932527 Not Applicable
38 A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome Completed NCT03594201
39 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
40 Serum and Semen Vitamin D Level With Semen Parameters Not yet recruiting NCT03477136

Search NIH Clinical Center for Oligoasthenoteratozoospermia

Genetic Tests for Oligoasthenoteratozoospermia

Anatomical Context for Oligoasthenoteratozoospermia

MalaCards organs/tissues related to Oligoasthenoteratozoospermia:

42
Bone, Bone Marrow, Testis

Publications for Oligoasthenoteratozoospermia

Articles related to Oligoasthenoteratozoospermia:

(show top 50) (show all 61)
# Title Authors Year
1
The use of insulin-like growth factor 1 improved the parameters of the seminogram in a patient with severe oligoasthenoteratozoospermia. ( 30858973 )
2019
2
TDRD6 is associated with oligoasthenoteratozoospermia by sequencing the patient from a consanguineous family. ( 29551503 )
2018
3
Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria. ( 29500854 )
2018
4
Sperm chromatin and DNA integrity, methyltransferase mRNA levels, and global DNA methylation in oligoasthenoteratozoospermia. ( 29662821 )
2018
5
The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. ( 29984205 )
2018
6
Increasing evidence of the role of the sperm epigenome in embryogenesis: oligoasthenoteratozoospermia, altered embryo DNA methylation, and miscarriage. ( 30098686 )
2018
7
The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia and immotile short tail sperm defects. ( 28138870 )
2017
8
Partial Deletions of Y-Chromosome in Infertile Men with Non-obstructive Azoospermia and Oligoasthenoteratozoospermia in a Turkish Population. ( 28438864 )
2017
9
Effect of modifiable lifestyle factors and antioxidant treatment on semen parameters of men with severe oligoasthenoteratozoospermia. ( 27859525 )
2017
10
Antioxidant therapy in idiopathic oligoasthenoteratozoospermia. ( 28717270 )
2017
11
The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study. ( 28245352 )
2017
12
Association of large scale 4977-bp "common" deletions in sperm mitochondrial DNA with asthenozoospermia and oligoasthenoteratozoospermia. ( 27110076 )
2016
13
Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and PycnogenolAr. ( 26428638 )
2015
14
Efficacy of tamoxifen and l-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia. ( 25274200 )
2015
15
Treatment strategies for severe oligoasthenoteratozoospermia (OAT) (<0.1 million/mL) patients. ( 26266459 )
2015
16
Pregnancy outcome after ICSI with thawed testicular sperm from men with non-obstructive azoospermia compared to ICSI with ejaculated sperm from men with severe oligoasthenoteratozoospermia and IVF with normal ejaculated sperm. ( 24303883 )
2014
17
Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci. ( 25329700 )
2014
18
Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia. ( 24550984 )
2014
19
Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. ( 24800224 )
2014
20
Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia. ( 25709639 )
2014
21
The role of hormones on semen parameters in patients with idiopathic or varicocele-related oligoasthenoteratozoospermia (OAT) syndrome. ( 23933342 )
2013
22
The association of seminal plasma antioxidant levels and sperm chromatin status with genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) in infertile men with oligoasthenoteratozoospermia. ( 23324581 )
2013
23
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. ( 23550190 )
2013
24
Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. ( 23697839 )
2013
25
Density gradient centrifugation prior to cryopreservation and hypotaurine supplementation improve post-thaw quality of sperm from infertile men with oligoasthenoteratozoospermia. ( 23760160 )
2013
26
Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. ( 23052838 )
2013
27
Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers. ( 23628110 )
2013
28
A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress. ( 23716949 )
2012
29
Recombinant human FSH reduces sperm DNA fragmentation in men with idiopathic oligoasthenoteratozoospermia. ( 21868752 )
2012
30
The effect of coenzyme Q₁₀ supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. ( 22081410 )
2012
31
A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. ( 20824894 )
2011
32
Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. ( 21399391 )
2011
33
A rare Y chromosome constitutional rearrangement: a partial AZFb deletion and duplication within chromosome Yp in an infertile man with severe oligoasthenoteratozoospermia. ( 21950337 )
2011
34
Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. ( 21219381 )
2011
35
Activation of the immune system and sperm DNA fragmentation are associated with idiopathic oligoasthenoteratospermia in men with couple subfertility. ( 21704215 )
2011
36
Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified? ( 21716893 )
2011
37
Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia : A double blind randomized placebo-controlled trial. ( 22022059 )
2011
38
Inositol activity in oligoasthenoteratospermia--an in vitro study. ( 21222378 )
2010
39
A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single aneuploidy and diploidy by five-color fluorescence in situ hybridization using one probe set. ( 18036525 )
2008
40
Correction of failed fertilization despite intracytoplasmic sperm injection with oligoasthenoteratozoospermia but with acrosomes present by oocyte activation with calcium ionophore--case report. ( 19205437 )
2008
41
A study to sustain the hypothesis of the multiple genesis of oligoasthenoteratospermia in human idiopathic infertile males. ( 18562708 )
2008
42
Analysis of the CAG repeat number in exon 1 of the androgen receptor gene in Slovene men with idiopathic azoospermia and oligoasthenoteratozoospermia. ( 17334597 )
2007
43
Male idiopathic oligoasthenoteratozoospermia. ( 16491265 )
2006
44
Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10). ( 17027368 )
2006
45
A mouse model of familial oligoasthenoteratozoospermia. ( 15705627 )
2005
46
Pathophysiology of oligoasthenoteratozoospermia: are we improving in the diagnosis? ( 14656405 )
2003
47
The value of sperm pooling and cryopreservation in patients with transient azoospermia or severe oligoasthenoteratozoospermia. ( 11756381 )
2002
48
Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression. ( 11821108 )
2002
49
Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology. ( 11134367 )
2001
50
Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermia. ( 11277880 )
2001

Variations for Oligoasthenoteratozoospermia

Copy number variations for Oligoasthenoteratozoospermia from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 266850 Y 11300000 57772954 Microdeletion Oligoasthenoteratozoospermia

Expression for Oligoasthenoteratozoospermia

Search GEO for disease gene expression data for Oligoasthenoteratozoospermia.

Pathways for Oligoasthenoteratozoospermia

Pathways related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.12 GSTM1 GSTP1
2
Show member pathways
10.8 GSTM1 GSTP1
3 10.42 GSTM1 GSTP1
4 10 GSTM1 GSTP1

GO Terms for Oligoasthenoteratozoospermia

Biological processes related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.26 GSTM1 GSTP1
2 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.16 AR GSTP1
3 spermatogenesis GO:0007283 9.02 AR DAZL LRGUK SPINK2 TDRD6
4 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM1 GSTP1

Molecular functions related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTP1
2 glutathione binding GO:0043295 8.62 GSTM1 GSTP1

Sources for Oligoasthenoteratozoospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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