OAT
MCID: OLG022
MIFTS: 36

Oligoasthenoteratozoospermia (OAT)

Categories: Reproductive diseases

Aliases & Classifications for Oligoasthenoteratozoospermia

MalaCards integrated aliases for Oligoasthenoteratozoospermia:

Name: Oligoasthenoteratozoospermia 12 15
Oligoasthenoteratospermia 12
Oat 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070311

Summaries for Oligoasthenoteratozoospermia

Disease Ontology : 12 A form of male infertility that is characterized by a combination of low number or oligozoospermia, poor motility or asthenozoospermia, and abnormal shape or teratozoospermia of sperms. OAT is the most common cause of male subfertility.

MalaCards based summary : Oligoasthenoteratozoospermia, also known as oligoasthenoteratospermia, is related to oligospermia and varicocele. An important gene associated with Oligoasthenoteratozoospermia is RABL2B (RAB, Member Of RAS Oncogene Family Like 2B), and among its related pathways/superpathways are Reproduction and Naphthalene metabolism. The drugs Levoleucovorin and Inositol have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and heart, and related phenotype is reproductive system.

Wikipedia : 73 Male infertility refers to a male's inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Oligoasthenoteratozoospermia

Diseases related to Oligoasthenoteratozoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 oligospermia 30.9 TNP2 PRM2 GSTP1 GSTM1 AR AMH
2 varicocele 29.8 GSTM1 AR AMH ACR
3 spermatogenic failure 6 29.8 SPATA16 ACR
4 male infertility 29.4 TNP2 SPATA16 PRM2 MIR34C MIR34B GSTM1
5 infertility 29.2 TNP2 SPATA16 PRM2 MIR34C MIR34B CATSPER2
6 gyrate atrophy of choroid and retina 11.7
7 lung oat cell carcinoma 11.3
8 eye disease 11.1
9 retinal degeneration 11.1
10 esophagus small cell carcinoma 11.1
11 azoospermia 11.0
12 norrie disease 11.0
13 cystinuria 11.0
14 3-methylglutaconic aciduria, type iii 11.0
15 choroid disease 11.0
16 fundus dystrophy 11.0
17 gallbladder small cell carcinoma 11.0
18 prostate small cell carcinoma 10.9
19 spermatogenic failure 12 10.9
20 small cell cancer of the lung 10.9
21 extrahepatic bile duct small cell adenocarcinoma 10.9
22 ornithinemia 10.9
23 argininemia 10.8
24 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 10.8
25 hyperprolinemia, type i 10.8
26 orotic aciduria 10.8
27 paine syndrome 10.8
28 cerebral creatine deficiency syndrome 2 10.8
29 hyperoxaluria, primary, type iii 10.8
30 neu-laxova syndrome 2 10.8
31 cerebral creatine deficiency syndrome 10.8
32 postinfectious encephalitis 10.8
33 bird fancier's lung 10.8
34 uveal disease 10.8
35 parapsoriasis 10.8
36 hair whorl 10.6
37 small cell carcinoma 10.5
38 hypercholesterolemia, familial, 1 10.4
39 rapidly involuting congenital hemangioma 10.4
40 celiac disease 1 10.3
41 dermatitis, atopic 10.2
42 carcinoid syndrome 10.2
43 dysphagia 10.1
44 coronary heart disease 1 10.1
45 myocardial infarction 10.1
46 dermatitis 10.1
47 hyperglycemia 10.1
48 testicular gonadoblastoma 10.1 VIM AMH
49 catsper-related male infertility 10.1 CATSPER2 CATSPER1
50 methane production 10.0

Graphical network of the top 20 diseases related to Oligoasthenoteratozoospermia:



Diseases related to Oligoasthenoteratozoospermia

Symptoms & Phenotypes for Oligoasthenoteratozoospermia

MGI Mouse Phenotypes related to Oligoasthenoteratozoospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.36 ACR AMH AR CATSPER1 CATSPER2 CATSPER3

Drugs & Therapeutics for Oligoasthenoteratozoospermia

Drugs for Oligoasthenoteratozoospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2 149436
2
Inositol Approved, Investigational, Withdrawn Phase 2, Phase 3 87-89-8
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4 Micronutrients Phase 2, Phase 3
5 Trace Elements Phase 2, Phase 3
6 Nutrients Phase 2, Phase 3
7 Vitamin B Complex Phase 2, Phase 3
8 Folate Phase 2, Phase 3
9 Hematinics Phase 2, Phase 3
10 Vitamins Phase 2, Phase 3
11 Vitamin B9 Phase 2, Phase 3
12
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
13
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
14
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
15
Calcitriol Approved, Nutraceutical Phase 2 32222-06-3 134070 5280453
16 Dihydroxycholecalciferols Phase 2
17 Hormones Phase 2
18 Vasoconstrictor Agents Phase 2
19 Calciferol Phase 2
20 Dermatologic Agents Phase 2
21 Calcium, Dietary Phase 2
22 Keratolytic Agents Phase 2
23
Calcium Nutraceutical Phase 2 7440-70-2 271
24
Ethanol Approved 64-17-5 702
25 Omega 3 Fatty Acid
26 Protective Agents
27 Antioxidants
28 carnitine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing IVF Cycles Completed NCT01828710 Phase 2, Phase 3
2 A Pilot Trial of 13-cis Retinoic Acid (Isotretinoin) for the Treatment of Men With Oligoasthenoteratozoospermia Completed NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
3 Omega-3 Polyunsaturated Fatty Acids for the Treatment of Patients With Idiopathic Oligoasthenoteratospermia: A Double-blind, Placebo-controlled and Randomized Exploratory Clinical Trial Unknown status NCT03634644 Omega 3 fatty acid;Placebo oral capsule
4 Investigating the Effect of Modifiable Lifestyle Factors in Severe Oligoasthenotertozoospermic Men Combined With Antioxidant Treatment Prior ICSI Unknown status NCT02752555

Search NIH Clinical Center for Oligoasthenoteratozoospermia

Genetic Tests for Oligoasthenoteratozoospermia

Anatomical Context for Oligoasthenoteratozoospermia

MalaCards organs/tissues related to Oligoasthenoteratozoospermia:

40
Bone, Lung, Heart, Liver, Kidney, Testis, Endothelial

Publications for Oligoasthenoteratozoospermia

Articles related to Oligoasthenoteratozoospermia:

(show top 50) (show all 411)
# Title Authors PMID Year
1
Biochemical Assessments of Seminal Plasma Zinc, Testis-Expressed Sequence 101 and Free Amino Acids and Their Correlations with Reproductive Hormones in Male Infertility. 61
32767245 2021
2
Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility. 61
32572802 2021
3
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans. 61
33037173 2021
4
High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes. 61
33648045 2021
5
Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature. 61
33766143 2021
6
Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting. 61
33723100 2021
7
Mutations in the desert hedgehog (DHH) gene in the disorders of sexual differentiation and male infertility. 61
33712994 2021
8
The impact of cryopreservation on the morphology of spermatozoa in men with oligoasthenoteratozoospermia. 61
33667435 2021
9
Association of XRCC1 and ERCC2 promoters' methylation with chromatin condensation and sperm DNA fragmentation in idiopathic oligoasthenoteratozoospermic men. 61
33355950 2021
10
COVID-19 and male reproductive function: a prospective, longitudinal cohort study. 61
33522983 2021
11
Investigation of molecular cryopreservation, fertility potential and microRNA-mediated apoptosis in Oligoasthenoteratozoospermia men. 61
33057898 2021
12
Correction to: Seminal Plasma and Serum Afamin Levels Are Associated with Infertility in Men with Oligoasthenoteratozoospermia. 61
33616885 2021
13
Decreased prostate-specific membrane antigen levels in the seminal plasma of oligoasthenoteratozoospermic men. 61
33108820 2021
14
Structural analysis of the impact of a novel androgen receptor gene mutation in two adult patients with mild androgen insensitivity syndrome. 61
33108824 2021
15
Underexpression of hsa-miR-449 family and their promoter hypermethylation in infertile men: A case-control study. 61
33554000 2021
16
Abnormal fertilization in ICSI and its association with abnormal semen parameters: a retrospective observational study on 1855 cases. 61
33510051 2021
17
A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12. 61
33497043 2021
18
Seminal Plasma and Serum Afamin Levels Are Associated with Infertility in Men with Oligoasthenoteratozoospermia. 61
33409873 2021
19
Frequency of Sperm Aneuploidy in Oligoasthenoteratozoospermic (OAT) Patients by Comprehensive Chromosome Screening: A Proof of Concept. 61
33680886 2021
20
In vivo acridine orange human spermatozoa staining-A new perspective for RNA detection and spermatozoa morphology evaluation. 61
32840006 2021
21
Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice. 61
33543287 2021
22
Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice. 61
33377946 2020
23
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis. 61
33371103 2020
24
Sperm chromosome abnormalities in patients with normal karyotype and in translocation carriers: clinical relevance for assisted reproductive technology. 61
33032906 2020
25
Identification of the PRM1 gene mutations in oligoasthenoteratozoospermic men. 61
33118225 2020
26
Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men. 61
32985280 2020
27
Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis. 61
31489847 2020
28
Men with idiopathic oligoasthenoteratozoospermia exhibit lower serum and seminal plasma melatonin levels: Comparative effect of night-light exposure with fertile males. 61
32509010 2020
29
Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice. 61
32272448 2020
30
Cystic fibrosis gene mutations and polymorphisms in Saudi men with infertility. 61
32757986 2020
31
Empiric therapy for idiopathic oligoasthenoteratozoospermia. 61
32284159 2020
32
First custom next-generation sequencing infertility panel in Latin America: design and first results. 61
32155011 2020
33
Large-scale mtDNA deletions as genetic biomarkers for susceptibility to male infertility: A systematic review and meta-analysis. 61
32360203 2020
34
Semen Quality is Associated with Sperm Aneuploidy and DNA Fragmentation in the United Arab Emirates Population. 61
32208936 2020
35
Molecular cytogenetic characterization of small supernumerary marker 15 in infertile male: A case report. 61
32256778 2020
36
Comparison between semen parameters in specimens collected early in the morning and in the evening. 61
32195611 2020
37
Artificial oocyte activation to improve reproductive outcomes in couples with various causes of infertility: a retrospective cohort study. 61
32201115 2020
38
The efficacy of combined l-carnitine and l-acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis. 61
31701550 2020
39
Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing-thawing process? 61
31845062 2020
40
Metabolomics analysis of seminal plasma in patients with idiopathic Oligoasthenoteratozoospermia using high-resolution NMR spectroscopy. 61
31520509 2020
41
HIPK4 is essential for murine spermiogenesis. 61
32163033 2020
42
Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking. 61
31218450 2020
43
MicroRNA-based regulatory circuit involved in sperm infertility. 61
31762071 2020
44
Spontaneous fertility and variable spectrum of reproductive phenotype in a family with adult-onset X-linked adrenal insufficiency harboring a novel DAX-1/NR0B1 mutation. 61
32028936 2020
45
Expression and Methylation Pattern of hsa-miR-34 Family in Sperm Samples of Infertile Men. 61
32046388 2020
46
[Abnormal semen analyses in men undergoing premarital screening and in infertile couples in Butembo-Democratic Republic of Congo]. 61
33425188 2020
47
First successful live birth following the use of MSOME and time lapse for sperm and embryo selections in a patient with severe male factor infertility: A case report. 61
30898628 2019
48
Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility. 61
31860974 2019
49
Evaluation of the antioxidative enzymes in the seminal plasma of infertile men: Contribution to classic semen quality analysis. 61
30964348 2019
50
Effects of antioxidant treatment on seminal parameters in patients undergoing in vitro fertilization. 61
31577104 2019

Variations for Oligoasthenoteratozoospermia

Copy number variations for Oligoasthenoteratozoospermia from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 266850 Y 11300000 57772954 Microdeletion Oligoasthenoteratozoospermia

Expression for Oligoasthenoteratozoospermia

Search GEO for disease gene expression data for Oligoasthenoteratozoospermia.

Pathways for Oligoasthenoteratozoospermia

Pathways related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.81 CATSPER3 CATSPER2 CATSPER1 ACR
2 10.34 GSTP1 GSTM1

GO Terms for Oligoasthenoteratozoospermia

Cellular components related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.63 VIM RABL2B HOATZ CATSPER3 CATSPER2 CATSPER1
2 motile cilium GO:0031514 9.43 CATSPER3 CATSPER2 CATSPER1
3 cilium GO:0005929 9.35 RABL2B HOATZ CATSPER3 CATSPER2 CATSPER1
4 CatSper complex GO:0036128 8.8 CATSPER3 CATSPER2 CATSPER1

Biological processes related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.91 TNP2 TDRD6 SPATA16 PRM2 CATSPER3 CATSPER2
2 cell differentiation GO:0030154 9.86 TNP2 TDRD6 SPATA16 PRM2 CATSPER3 CATSPER2
3 calcium ion transport GO:0006816 9.72 CATSPER3 CATSPER2 CATSPER1
4 calcium ion transmembrane transport GO:0070588 9.7 CATSPER3 CATSPER2 CATSPER1
5 sperm capacitation GO:0048240 9.54 CATSPER3 CATSPER2
6 glutathione derivative biosynthetic process GO:1901687 9.51 GSTP1 GSTM1
7 response to progesterone GO:0032570 9.5 CATSPER3 CATSPER2 CATSPER1
8 acrosome reaction GO:0007340 9.49 TNP2 ACR
9 positive regulation of connective tissue replacement GO:1905205 9.48 MIR34C MIR34B
10 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.46 MIR34C MIR34B
11 hepoxilin biosynthetic process GO:0051122 9.43 GSTP1 GSTM1
12 penetration of zona pellucida GO:0007341 9.4 TNP2 ACR
13 sperm-egg recognition GO:0035036 9.33 CATSPER3 CATSPER2 CATSPER1
14 spermatogenesis GO:0007283 9.28 TNP2 TDRD6 SPATA16 PRM2 HOATZ CATSPER3
15 flagellated sperm motility GO:0030317 9.26 HOATZ CATSPER3 CATSPER2 CATSPER1

Molecular functions related to Oligoasthenoteratozoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.43 CATSPER3 CATSPER2 CATSPER1
2 calcium activated cation channel activity GO:0005227 9.16 CATSPER2 CATSPER1
3 calcium channel activity GO:0005262 9.13 CATSPER3 CATSPER2 CATSPER1
4 glutathione binding GO:0043295 8.62 GSTP1 GSTM1

Sources for Oligoasthenoteratozoospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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