Aliases & Classifications for Oligohydramnios

MalaCards integrated aliases for Oligohydramnios:

Name: Oligohydramnios 12 29 54 6 44 15 17 71 32
Oligohydramnios - Delivered 12 71
Oligohydramnios, Antepartum Condition or Complication 71
Antepartum Oligohydramnios 12
Delivered Oligohydramnios 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12215
ICD9CM 34 658.0
MeSH 44 D016104
NCIt 50 C92839
SNOMED-CT 67 157051001
ICD10 32 O41.0
UMLS 71 C0079924 C0157142 C0157143

Summaries for Oligohydramnios

Disease Ontology : 12 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards based summary : Oligohydramnios, also known as oligohydramnios - delivered, is related to potter's syndrome and renal tubular dysgenesis, and has symptoms including morning sickness An important gene associated with Oligohydramnios is PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Oxytocin signaling pathway. The drugs Tocopherol and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include kidney, placenta and fetal lung, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Related Diseases for Oligohydramnios

Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 potter's syndrome 32.9 REN PKHD1 AGT ACE
2 renal tubular dysgenesis 32.5 REN AGTR1 AGT ACE
3 renal hypodysplasia/aplasia 1 32.0 REN PKHD1 AGTR1 AGT ACE
4 multiple pterygium syndrome, lethal type 31.9 CHRNG CHRND CHRNA1
5 polycystic kidney disease 4 with or without polycystic liver disease 31.9 TMEM67 PKHD1 CC2D2A
6 urinary tract obstruction 31.1 REN AQP1 ACE
7 polyhydramnios 31.0 OXT NPPB EDN1 AQP3 AQP1 AFP
8 renal dysplasia 30.9 REN AGTR1 AGT ACE
9 anuria 30.9 REN AGTR1 AGT ACE
10 posterior urethral valves 30.8 AGTR1 AGT ACE
11 respiratory failure 30.6 REN NPPB EDN1 ADM ACE
12 vesicoureteral reflux 1 30.5 REN AGTR1 AGT ACE
13 diabetes insipidus 30.4 REN OXT AQP3 AFP
14 eclampsia 30.4 REN OXT EDN1 AGT ACE
15 placenta praevia 30.3 OXT CHRND
16 pulmonary hypertension 30.3 REN NPPB EDN1 AGTR1 AGT ADM
17 end stage renal disease 30.3 REN NPPB AGTR1 AGT ACE
18 pre-eclampsia 30.3 REN OXT EDN1 AGTR1 AGT AFP
19 microvascular complications of diabetes 3 30.2 REN AGTR1 ACE
20 triploidy 30.2 CGA AFP
21 placenta disease 30.2 REN OXT MIR517A CGA AFP
22 polycystic kidney disease 30.1 TMEM67 REN PKHD1 EDN1 CC2D2A AQP3
23 chronic kidney disease 30.1 REN NPPB EDN1 AGTR1 AGT ADM
24 patent ductus arteriosus 1 30.1 REN NPPB EDN1 ACE
25 cystic lymphangioma 30.1 CHRNG CHRND CHRNA1 AFP
26 persistent fetal circulation syndrome 30.1 REN OXT EDN1
27 pulmonary edema 29.9 REN OXT NPPB EDN1 AGTR1 ACE
28 autosomal dominant polycystic kidney disease 29.8 REN PKHD1 EDN1 AQP3 AQP1 AGTR1
29 kidney disease 29.4 TMEM67 REN PKHD1 NPPB EDN1 CC2D2A
30 bilateral renal agenesis dominant type 11.1
31 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.9
32 urethral obstruction sequence 10.9
33 trisomy 2 mosaicism 10.9
34 meckel syndrome, type 1 10.9
35 twin-to-twin transfusion syndrome 10.9
36 severe pre-eclampsia 10.9
37 congenital anomalies of kidney and urinary tract 2 10.9
38 renal dysplasia-limb defects syndrome 10.9
39 meckel syndrome, type 7 10.9
40 fetal indomethacin syndrome 10.9
41 cardiac tuberculosis 10.5 NPPB ACE
42 hypoaldosteronism 10.5 REN ACE
43 renal artery obstruction 10.5 REN ACE
44 polycystic kidney disease 4 10.5 PKHD1 NPPB
45 hydrarthrosis 10.5 AQP3 AQP1
46 orthostatic proteinuria 10.5 REN ACE
47 toxic myocarditis 10.5 NPPB ACE
48 acute pulmonary heart disease 10.5 REN NPPB
49 acute cor pulmonale 10.5 REN NPPB
50 spinal cord lipoma 10.5 AFP ACE

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to Oligohydramnios

Symptoms & Phenotypes for Oligohydramnios

UMLS symptoms related to Oligohydramnios:


morning sickness

MGI Mouse Phenotypes related to Oligohydramnios:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 ACE ADM AFP AGT AGTR1 AQP1
2 growth/size/body region MP:0005378 10.17 ACE AGT AGTR1 AQP1 AQP3 CC2D2A
3 mortality/aging MP:0010768 10.16 ACE ADM AFP AGT AGTR1 AQP1
4 cardiovascular system MP:0005385 10.15 ACE ADM AGT AGTR1 AQP1 AQP3
5 nervous system MP:0003631 10 ACE AGT AGTR1 AQP1 CC2D2A CGA
6 renal/urinary system MP:0005367 9.73 ACE ADM AGT AGTR1 AQP1 AQP3
7 reproductive system MP:0005389 9.32 ACE ADM AFP AGT AQP1 CGA

Drugs & Therapeutics for Oligohydramnios

Drugs for Oligohydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2
2
Warfarin Approved Phase 4 81-81-2 6691 54678486
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Tocotrienol Investigational Phase 4 6829-55-6
5
Coumarin Experimental Phase 4 91-64-5 323
6 Protective Agents Phase 4
7 Antioxidants Phase 4
8 Omega 3 Fatty Acid Phase 4
9 Vitamins Phase 4
10 Tocotrienols Phase 4
11 Tocopherols Phase 4
12 Coagulants Phase 4
13 Anticoagulants Phase 4
14
Dinoprostone Approved Phase 3 363-24-6 5280360
15
Isosorbide Dinitrate Approved, Investigational Phase 2, Phase 3 87-33-2 6883
16
AT-101 Approved, Investigational Phase 2, Phase 3 90141-22-3, 652-67-5 12597
17
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
18 diuretics Phase 2, Phase 3
19 isosorbide-5-mononitrate Phase 2, Phase 3
20 Vasodilator Agents Phase 2, Phase 3
21 Pharmaceutical Solutions Phase 1
22 Anesthetics Phase 1
23 Anesthetics, Local Phase 1
24
Sodium citrate Approved, Investigational 68-04-2
25
Caffeine Approved 58-08-2 2519
26
Misoprostol Approved 59122-46-2 5282381
27
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
28 Citrate
29 Phosphodiesterase Inhibitors
30 Phosphodiesterase 5 Inhibitors
31 Sildenafil Citrate 171599-83-0
32 Gastrointestinal Agents
33 Antacids
34 Anti-Ulcer Agents

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Role of Antioxidants in Unexplained Oligohydramnios,A Randomized Trial Completed NCT01990690 Phase 4 anti oxidant omega 3
2 a Randomized Clinical Trial Using Oral Anti Coagulant in the Management of Unexplained Oligohydramnios Terminated NCT01569035 Phase 4 warfarin
3 Open Randomized Trial Comparing Perinatal Outcome Following Expectant Management Versus Amnioinfusion in PPROM <25 Wks With Persistent Oligohydramnios Unknown status NCT00787163 Phase 3
4 Induction of Labor in Oligohydramnios - A Comparison Between Two Modes of Cervical Ripening for Patients With Oligohydramnios at Term Unknown status NCT00815542 Phase 3 prostaglandins E2
5 Randomized Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
6 Nitric Oxide Donors for Treatment of Isolated Oligohydramnios: A Pilot Study Completed NCT02712125 Phase 2, Phase 3 isosorbide mononitrate;Placebo
7 Alterations of the Uteroplacental and Fetal Pulmonary Circulation in Patients With Severe Idiopathic Oligohydramnios Following Amnioinfusion Therapy in a Longitudinal Study Unknown status NCT01258725 Phase 1
8 Renal Anhydramnios Fetal Therapy (RAFT) Trial Recruiting NCT03101891 Phase 1 Isotonic fluid
9 The Influence of Low Sodium Diet on an Amniotic Fluid Index in a Patient That Diagnosed With Oligohydramnios and Assigned for Conservative Management - a Randomized Controlled Trial Unknown status NCT03815968
10 Third Trimester Fetal Renal Artery Doppler Indices in Borderline Idiopathic Isolated Oligohydramnios and Relationship Between Neonatal Outcomes Unknown status NCT02901340
11 Does the Amniotic Fluid Index Affect the Fetal Cardiac Performance? Unknown status NCT03277417
12 Sildenafil Citrate Therapy for Oligohydramnios Unknown status NCT02372487 sildenafil citrate
13 The Effect of Coffee Consumption on Fetal Renal Artery Blood Flow and Amniotic Fluid Volume in the Third Trimester of Pregnancy Completed NCT03798275
14 Management of Active Induction of Labor in Pregnancies Complicated With Oligohydramnios at Term; the Mode of Delivery and the Neonatal Outcomes Completed NCT02581774
15 Classification of Fetal Breathing Patterns in the Maturing Upper Airway: Spectral Waveform Analysis of Amniotic Fluid Flow Dynamics in Normal Development, Polyhydramnios, and Oligohydramnios Completed NCT00066976
16 Clinical Utility of Uterine, Fetal Cerebral Doppler and Oligohydramnios to Predict Abnormal Heart Rate Tracings in Pregnancies at or Beyond 41 Weeks Completed NCT03703037
17 TRANSCERVICAL FOLEY CATHETER (FOLEY) Versus INTRAVAGINAL MISOPROSTOL FOR CERVICAL RIPENING AND INDUCTION OF LABOR: A RANDOMIZED CLINICAL TRIAL. Completed NCT01140971 Misoprostol
18 The Pseudo-Oligohydramnios/Hidden Pocket Study: The Added Contribution of Transvaginal Sonographic Evaluation of Amniotic Fluid Index Recruiting NCT03935607
19 Patient Registry for Women Diagnosed With Preterm Premature Rupture of Membranes or PPROM During Pregnancy Recruiting NCT02997345
20 Dilapan-S®: A Multicenter US E-registry Enrolling by invitation NCT04451109
21 Effect of Zamzam Water on Amniotic Fluid Index, in Oligohydramnios : a Randomized Controlled Trial Not yet recruiting NCT04684680
22 Submersion Therapy for the Reversal of Oligohydramnios; A Non-invasive Gentle Approach Terminated NCT01682928 IV/Oral Hydration and Bedrest

Search NIH Clinical Center for Oligohydramnios

Cochrane evidence based reviews: oligohydramnios

Genetic Tests for Oligohydramnios

Genetic tests related to Oligohydramnios:

# Genetic test Affiliating Genes
1 Oligohydramnios 29

Anatomical Context for Oligohydramnios

MalaCards organs/tissues related to Oligohydramnios:

40
Kidney, Placenta, Fetal Lung, Brain, Breast, Thyroid, Lung

Publications for Oligohydramnios

Articles related to Oligohydramnios:

(show top 50) (show all 2585)
# Title Authors PMID Year
1
The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns. 61 54
17653738 2008
2
Abnormal fetal heart rate tracing patterns during the first stage of labor: effect on perinatal outcome. 54 61
11641667 2001
3
[Activity of N-b-D-acetylglucosaminidase molecular forms in amniotic fluid of tobacco smoking pregnant women with oligohydramnios or premature rupture of the membrane complications]. 61 54
10860257 2000
4
Prediction of adverse perinatal outcome by maternal serum screening for Down syndrome in an Asian population. 61 54
9170469 1997
5
Elevated alpha-fetoprotein and human chorionic gonadotropin as a marker for placental trisomy 16 in the second trimester? 61 54
8750291 1995
6
Maternal serum markers in second-trimester oligohydramnios. 61 54
7526364 1994
7
Origin of raised maternal serum alpha-fetoprotein levels in second-trimester oligohydramnios. 61 54
1372972 1992
8
Amniotic fluid N-acetyl-beta-D-glucosaminidase activity and renal abnormalities. 61 54
1750765 1991
9
[Oligohydramnios in mid-term pregnancy: analysis of 182 cases]. 61 54
2027677 1991
10
Inherited thrombophilia is significantly associated with severe preeclampsia. 61
33603868 2021
11
Fetal brain hemodynamics in pregnancies at term: correlation with gestational age, birthweight and clinical outcome. 61
31288578 2021
12
Open Fetal Microneurosurgery for Intrauterine Spina Bifida Repair. 61
33582666 2021
13
The Association Between BMP-2, UQCC1 and CX3CR1 Polymorphisms and the Risk of Developmental Dysplasia of the Hip. 61
33569111 2021
14
Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus: A STROBE-compliant study. 61
33592909 2021
15
Monozygotic twins discordant for homologous Robertsonian translocation trisomy 21 of 46, XX, + 21, der (21;21) (q10; q10) in a twin-to-twin transfusion syndrome, case report. 61
33516175 2021
16
Prolonged early antenatal indomethacin exposure is safe for fetus and neonate. 61
30905227 2021
17
Evaluation of Pulmonary Hypoplasia in Various Congenital Anomalies with a Comparison of Two Conventional Methods of Assessment: Radial Alveolar Count (RAC) and Lung Weight: Body Weight Ratio (LBW). 61
33432563 2021
18
Risk factors for adverse outcomes in vaginal preterm breech labor. 61
32767041 2021
19
Twin-twin transfusion syndrome - a University Hospital experience with intrauterine treatment. 61
33503142 2021
20
Expression and Regulation of Aquaporins in Pregnancy Complications and Reproductive Dysfunctions. 61
33226842 2021
21
Association of placental chorangiosis with pregnancy complication and prenatal outcome: a case-control study. 61
33516193 2021
22
Analysis of risk factors for obstetric outcomes after hysteroscopic adhesiolysis for Asherman's syndrome: A retrospective cohort study. 61
33483955 2021
23
Histological distribution pattern of hemosiderin deposition on the chorionic plate and fetal membrane of diffuse chorioamniotic hemosiderosis related to chronic abruption oligohydramnios sequence. 61
33497930 2021
24
Uterine wall rupture in a primigravid patient with oligohydramnios as the first manifestation: A case report. 61
33466158 2021
25
Comparison of Perinatal Outcomes between Borderline and Normal Amniotic Fluid Index in Term Singleton Pregnancies. 61
33510515 2021
26
Amniotic fluid disorders and the effects on prenatal outcome: a retrospective cohort study. 61
33482755 2021
27
Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology-related complications. 61
33399234 2021
28
Use of angiotensin II receptor blocker during pregnancy: A case report. 61
33546057 2021
29
Association of cord blood ischemia-modified albumin level with abnormal foetal Doppler parameters in intrauterine growth-restricted foetuses. 61
30691329 2021
30
Neonatal outcomes following previable prelabour rupture of membranes before 23 weeks of gestation - A retrospective cohort study. 61
32224534 2021
31
Accuracy of predicting neonatal distress using a five-level classification of fetal heart rate monitoring. 61
32939941 2021
32
Prediction of In-Hospital Mortality After 24 Hours in Very Low Birth Weight Infants. 61
33310907 2021
33
Isolated oligohydramnios and long-term neurological morbidity of the offspring. 61
31755400 2020
34
Reducing emergency cesarean delivery and improving the primiparous experience: Findings of the RECIPE study. 61
33065516 2020
35
Periviable Premature Rupture of Membranes. 61
33121650 2020
36
Neonatal and Childhood Outcomes Following Preterm Premature Rupture of Membranes. 61
33121652 2020
37
Efficacy of Tranexamic Acid in Reducing Blood Loss in Lower Segment Cesearean Section: A Randomised Controlled Study. 61
33417631 2020
38
Determinants of adverse neonatal outcome in vaginal deliveries complicated by suspected intraamniotic infection. 61
32749533 2020
39
Minimizing abdominal incision for transverse uterine fundal incision by aspiration of amniotic fluid and reduction of uterine size. 61
33331020 2020
40
Potential effects of transdermal nitric oxide donor on fetal growth restriction and oligohydramnios: A case report. 61
33363920 2020
41
Risk factors for neonatal bronchopulmonary dysplasia in extremely preterm premature rupture of membranes: a retrospective study. 61
33143671 2020
42
Autosomal Recessive Renal Tubular Dysgenesis Caused by a Founder Mutation of Angiotensinogen. 61
33163725 2020
43
Can maternal characteristics on admission for preterm prelabor rupture of membranes predict pregnancy latency? 61
33345914 2020
44
Trends of change in the individual contribution of risk factors for small for gestational age over more than 2 decades. 61
32748052 2020
45
Isolated oligohydramnios - should induction be offered after 36 weeks? 61
33249965 2020
46
Routine third-trimester ultrasound in low-risk pregnancies and perinatal death: a systematic review and meta-analysis. 61
33345941 2020
47
A novel homozygous variant in REN in a family presenting with classic features of disorders involving the renin-angiotensin pathway, without renal tubular dysgenesis. 61
33043632 2020
48
The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary Hospital Experience. 61
33058100 2020
49
Outcomes after In Utero Myelomeningocele Repair Based on Delivery Location. 61
33120880 2020
50
Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review. 61
31999213 2020

Variations for Oligohydramnios

ClinVar genetic disease variations for Oligohydramnios:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CC2D2A NM_001080522.2(CC2D2A):c.1149+1G>A SNV Pathogenic 523401 rs1553827236 4:15518380-15518380 4:15516757-15516757
2 CC2D2A NM_001080522.2(CC2D2A):c.4179+1del Deletion Pathogenic 56312 rs386833760 4:15589552-15589552 4:15587929-15587929
3 PKHD1 NM_138694.4(PKHD1):c.107C>T (p.Thr36Met) SNV Pathogenic 4108 rs137852944 6:51947999-51947999 6:52083201-52083201
4 TMEM67 NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg) SNV Likely pathogenic 1383 rs201893408 8:94808198-94808198 8:93795970-93795970
5 OPHN1 NM_002547.3(OPHN1):c.746T>C (p.Leu249Pro) SNV Likely pathogenic 374192 rs1057518963 X:67430081-67430081 X:68210239-68210239
6 TMEM67 NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys) SNV Likely pathogenic 217725 rs752362727 8:94798483-94798483 8:93786255-93786255
7 PKHD1 NM_138694.4(PKHD1):c.2716-3C>G SNV Uncertain significance 374193 rs1057518964 6:51908531-51908531 6:52043733-52043733
8 LSM1 NM_014462.3(LSM1):c.231+4A>C SNV Uncertain significance 623485 rs775468919 8:38027316-38027316 8:38169798-38169798
9 INF2 NM_022489.4(INF2):c.3247A>G (p.Ser1083Gly) SNV Uncertain significance 523532 rs1555375554 14:105180746-105180746 14:104714409-104714409

Expression for Oligohydramnios

Search GEO for disease gene expression data for Oligohydramnios.

Pathways for Oligohydramnios

Pathways related to Oligohydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 OXT EDN1 CHRNG CHRND CHRNA1 CGA
2
Show member pathways
11.89 OXT NPPB EDN1 AGTR1 AGT ADM
3
Show member pathways
11.88 REN CGA AGT ACE
4 11.61 EDN1 AGTR1 AGT
5
Show member pathways
11.45 CHRNG CHRND CHRNA1
6
Show member pathways
11.36 REN AGTR1 AGT ACE
7 10.94 REN EDN1 AQP1 AGTR1 AGT ACE
8 10.48 CHRND CHRNA1

GO Terms for Oligohydramnios

Cellular components related to Oligohydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.1 TMEM67 REN PKHD1 OXT OPHN1 NPPB
2 extracellular region GO:0005576 9.61 REN OXT NPPB EDN1 CGA AGT
3 acetylcholine-gated channel complex GO:0005892 9.32 CHRND CHRNA1
4 extracellular space GO:0005615 9.28 REN OXT NPPB EDN1 CGA AGT
5 MKS complex GO:0036038 9.16 TMEM67 CC2D2A

Biological processes related to Oligohydramnios according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 OXT OPHN1 CHRNG CHRND CHRNA1 CGA
2 positive regulation of cell proliferation GO:0008284 10.04 PKHD1 EDN1 CGA AGT ADM
3 heart development GO:0007507 9.92 OXT EDN1 CC2D2A ADM
4 regulation of membrane potential GO:0042391 9.83 CHRNG CHRND CHRNA1
5 female pregnancy GO:0007565 9.81 OXT AGT ADM
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 OXT EDN1 AGTR1 AGT ADM
7 excitatory postsynaptic potential GO:0060079 9.77 CHRNG CHRND CHRNA1
8 nervous system process GO:0050877 9.73 CHRNG CHRND CHRNA1
9 regulation of postsynaptic membrane potential GO:0060078 9.72 CHRNG CHRND CHRNA1
10 low-density lipoprotein particle remodeling GO:0034374 9.66 AGTR1 AGT
11 positive regulation of cellular protein metabolic process GO:0032270 9.65 AGTR1 AGT
12 amyloid-beta metabolic process GO:0050435 9.65 REN ACE
13 positive regulation of urine volume GO:0035810 9.65 NPPB EDN1
14 angiotensin maturation GO:0002003 9.63 REN ACE
15 artery smooth muscle contraction GO:0014824 9.63 EDN1 AGT
16 positive regulation of prostaglandin secretion GO:0032308 9.62 OXT EDN1
17 positive regulation of cholesterol esterification GO:0010873 9.61 AGTR1 AGT
18 glycerol transport GO:0015793 9.61 AQP3 AQP1
19 regulation of blood vessel diameter GO:0097746 9.61 NPPB AGTR1 ACE
20 body fluid secretion GO:0007589 9.6 NPPB EDN1
21 drinking behavior GO:0042756 9.58 REN OXT
22 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGTR1 AGT
23 musculoskeletal movement GO:0050881 9.57 CHRND CHRNA1
24 regulation of vasoconstriction GO:0019229 9.56 EDN1 AGTR1 AGT ACE
25 regulation of blood pressure GO:0008217 9.55 REN NPPB EDN1 AGT ACE
26 regulation of renal sodium excretion GO:0035813 9.54 AGTR1 AGT
27 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.54 AGTR1 AGT ACE
28 skeletal muscle tissue growth GO:0048630 9.52 CHRND CHRNA1
29 nitric oxide transport GO:0030185 9.51 EDN1 AQP1
30 renin-angiotensin regulation of aldosterone production GO:0002018 9.5 REN AGTR1 AGT
31 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGTR1 AGT
32 regulation of renal output by angiotensin GO:0002019 9.48 AGT ACE
33 regulation of blood volume by renin-angiotensin GO:0002016 9.46 REN AGT
34 kidney development GO:0001822 9.43 REN PKHD1 CC2D2A AGTR1 AGT ACE
35 positive regulation of renal sodium excretion GO:0035815 8.92 OXT NPPB EDN1 AGT

Molecular functions related to Oligohydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.54 CHRNG CHRND CHRNA1
2 extracellular ligand-gated ion channel activity GO:0005230 9.5 CHRNG CHRND CHRNA1
3 acetylcholine receptor activity GO:0015464 9.46 CHRNG CHRNA1
4 water channel activity GO:0015250 9.43 AQP3 AQP1
5 channel activity GO:0015267 9.43 CHRNG AQP3 AQP1
6 acetylcholine binding GO:0042166 9.4 CHRND CHRNA1
7 bradykinin receptor binding GO:0031711 9.16 AGTR1 ACE
8 acetylcholine-gated cation-selective channel activity GO:0022848 9.13 CHRNG CHRND CHRNA1
9 hormone activity GO:0005179 9.1 OXT NPPB EDN1 CGA AGT ADM

Sources for Oligohydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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