MCID: OLG001
MIFTS: 41

Oligospermia

Categories: Reproductive diseases

Aliases & Classifications for Oligospermia

MalaCards integrated aliases for Oligospermia:

Name: Oligospermia 12 30 6 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD9CM 36 606.1
MeSH 45 D009845
NCIt 51 C34860
ICD10 34 N46.1 N46.11
UMLS 74 C0028960

Summaries for Oligospermia

Disease Ontology : 12 A male fertility issue defined as a low sperm concentration in the ejaculate.

MalaCards based summary : Oligospermia is related to varicocele and hypogonadotropism. An important gene associated with Oligospermia is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Transcription Androgen Receptor nuclear signaling. The drugs Metformin and Sodium Citrate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and pituitary, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 77 Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of... more...

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 varicocele 30.3 GSTM1 PRL
2 hypogonadotropism 30.2 GNRHR PRL
3 gynecomastia 30.0 AR PRL
4 bronchiectasis oligospermia 12.1
5 y chromosome infertility 11.7
6 spermatogenic failure, y-linked, 2 11.3
7 spermatogenic failure 4 11.1
8 androgen insensitivity, partial 11.1
9 azoospermia 10.7
10 infertility 10.5
11 male infertility 10.3
12 androgenic alopecia 10.2 AR PRL
13 johanson-blizzard syndrome 10.2 CFTR UBR2
14 impotence 10.1
15 psoriasis 10.1
16 bronchiectasis 10.1
17 oligoasthenoteratozoospermia 10.1 AR GSTM1
18 alopecia, androgenetic, 1 10.1 AR SRD5A2
19 hermaphroditism 10.1 AR SRD5A2
20 pseudovaginal perineoscrotal hypospadias 10.1 AR SRD5A2
21 autoimmune pancreatitis 10.0 CFTR UBR2
22 gonadal disease 10.0 AR GNRHR PRL
23 prostatic hyperplasia, benign 10.0 AR SRD5A2
24 androgen insensitivity syndrome 10.0 AR SRD5A2
25 testicular germ cell cancer 10.0 AR KITLG
26 hypogonadotropic hypogonadism 7 with or without anosmia 10.0
27 schizophrenia 10.0
28 cryptorchidism, unilateral or bilateral 10.0
29 adrenal hypoplasia, congenital 10.0
30 sexual disorder 10.0
31 infant gynecomastia 10.0
32 hypogonadism 10.0
33 testicular cancer 10.0
34 hyperglycemia 10.0
35 hypereosinophilic syndrome 10.0
36 pustular psoriasis 10.0
37 ring chromosome 12 10.0
38 scabies 9.8 GSTM1 KITLG

Comorbidity relations with Oligospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.96 AR CFTR GNRHR KITLG KLHL10 NFKB1
2 digestive/alimentary MP:0005381 9.8 AR CFTR GNRHR KITLG NFKB1 PYGO2
3 craniofacial MP:0005382 9.77 AR CFTR KITLG NFKB1 PYGO2
4 integument MP:0010771 9.63 AR GNRHR KITLG NFKB1 PRL PYGO2
5 liver/biliary system MP:0005370 9.35 AR CFTR KITLG NFKB1 PRL
6 reproductive system MP:0005389 9.32 AR CFTR GNRHR KITLG KLHL10 PRL

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Sodium Citrate Approved, Investigational Phase 4,Phase 3 68-04-2
3
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2 7440-70-2 271
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
5
Enclomiphene Investigational Phase 4,Phase 3 15690-57-0
6 Estrogen Receptor Modulators Phase 4,Phase 3
7 insulin Phase 4,Not Applicable
8 Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Estrogen Receptor Antagonists Phase 4,Phase 3
10 Selective Estrogen Receptor Modulators Phase 4,Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
12 Estrogen Antagonists Phase 4,Phase 3
13 Zuclomiphene Phase 4,Phase 3
14 Hypoglycemic Agents Phase 4,Not Applicable
15 Chorionic Gonadotropin Phase 4
16 Calcium, Dietary Phase 4,Phase 3,Phase 2
17 Anticoagulants Phase 4,Phase 3
18 Chelating Agents Phase 4,Phase 3
19 Insulin, Globin Zinc Phase 4,Not Applicable
20 Clomiphene Phase 4,Phase 3
21 Estrogens Phase 4,Phase 3
22 Fertility Agents Phase 4,Phase 3
23 Citrate Phase 4,Phase 3
24 Hormones Phase 4,Phase 3,Phase 2
25
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
26
Testosterone enanthate Approved Phase 3 315-37-7 9416
27
Methyltestosterone Approved Phase 3 58-18-4 6010
28
Testosterone Approved, Experimental, Investigational Phase 3 58-22-0, 481-30-1 10204 6013
29
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
30
leucovorin Approved Phase 2, Phase 3 58-05-9 143 6006
31 Ginger Approved Phase 3
32 English walnut Approved Phase 2, Phase 3
33
Polyestradiol phosphate Approved Phase 3 28014-46-2
34
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
35
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
37 Testosterone 17 beta-cypionate Phase 3
38 Vitamins Phase 2, Phase 3,Not Applicable
39 Nutrients Phase 2, Phase 3,Not Applicable
40 Trace Elements Phase 2, Phase 3,Not Applicable
41 Micronutrients Phase 2, Phase 3,Not Applicable
42 Steroid Synthesis Inhibitors Phase 3
43 Aromatase Inhibitors Phase 3
44 Vitamin B9 Phase 2, Phase 3
45 Folate Phase 2, Phase 3
46 Hematinics Phase 2, Phase 3
47 Vitamin B Complex Phase 2, Phase 3
48 Sweet Basil Phase 3
49 Anabolic Agents Phase 3
50 Estradiol 3-benzoate Phase 3

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Unknown status NCT02998593 Phase 3 Bahman capsules;Placebo
5 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
6 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
7 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
8 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
9 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
10 Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Not yet recruiting NCT03615547 Phase 3 Clomifene Citrate
11 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
12 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
13 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
14 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
15 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
16 Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
17 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
18 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584 Not Applicable
19 Severe Male Factor Infertility Management Unknown status NCT02752555 Not Applicable
20 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173 Not Applicable
21 Preimplantation Genetic Screening in Patients With Male Factor Infertility Unknown status NCT02941965 Not Applicable
22 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
23 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799 Not Applicable
24 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482 Not Applicable
25 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588 Not Applicable
26 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
27 Genetic Studies Spermatogenic Failure Completed NCT00548977
28 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Not Applicable Mesenchymal stem cell injection
29 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
30 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
31 A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome Completed NCT03594201
32 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
33 Is Oxidative Stress in Semen Reduced by Lifestyle Intervention Recruiting NCT03898752 Not Applicable
34 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
35 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Recruiting NCT03497728
36 Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia Recruiting NCT03634644 Not Applicable Omega 3 fatty acid;Placebo oral capsule
37 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Recruiting NCT02932527 Not Applicable
38 Fertility Preservation in Cases of Klinefelter Syndrome. Active, not recruiting NCT01918280 Not Applicable
39 Serum and Semen Vitamin D Level With Semen Parameters Not yet recruiting NCT03477136
40 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Not Applicable Ramipril;Placebo

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

# Genetic test Affiliating Genes
1 Oligospermia 30

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

42
Bone, Bone Marrow, Pituitary, Testis, Testes, Prostate

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 199)
# Title Authors Year
1
Correlation Analysis of miR-122-5p and Occludin with Sperm Density in Oligospermia Patients' Sperm. ( 30868853 )
2019
2
Whole Exome Sequencing Identifies a Rare Nonsense Mutation in FAM47C as a Possible Cause of Severe Oligospermia in Brothers With Varicocele. ( 30922974 )
2019
3
A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve. ( 31074776 )
2019
4
Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats. ( 31081692 )
2019
5
Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. ( 28730893 )
2018
6
Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. ( 28444774 )
2018
7
Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology. ( 29051002 )
2018
8
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity. ( 29739640 )
2018
9
Microscopic varicocelectomy as a treatment option for patients with severe oligospermia. ( 29744475 )
2018
10
NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study. ( 29942932 )
2018
11
Time to improvement in semen parameters after microsurgical varicocelectomy in men with severe oligospermia. ( 30169150 )
2018
12
Re: Men with Severe Oligospermia Appear to Benefit from Varicocele Repair: A Cost-Effectiveness Analysis of Assisted Reproductive Technology. ( 30412957 )
2018
13
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. ( 28367414 )
2017
14
Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia. ( 29404532 )
2017
15
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia. ( 27812445 )
2016
16
A novel nomogram for prediction of spermatogenic improvement following empiric medical therapy for moderate-severe oligospermia. ( 26892053 )
2016
17
Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ( 26940145 )
2016
18
A Role for Heterozygosity of NF-𝜅B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia. ( 27041523 )
2016
19
Re: Higher Pregnancy Rates Using Testicular Sperm in Men with Severe Oligospermia. ( 27597099 )
2016
20
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. ( 26345837 )
2015
21
Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China. ( 25532576 )
2015
22
Re: Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25986825 )
2015
23
Higher pregnancy rates using testicular sperm in men with severe oligospermia. ( 26363389 )
2015
24
Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia. ( 25536748 )
2014
25
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. ( 25106941 )
2014
26
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. ( 24369145 )
2014
27
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. ( 24631383 )
2014
28
Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. ( 24756080 )
2014
29
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25044085 )
2014
30
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia. ( 25109708 )
2014
31
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. ( 24002933 )
2013
32
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. ( 23384712 )
2013
33
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. ( 23885232 )
2013
34
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. ( 24034937 )
2013
35
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. ( 24083421 )
2013
36
Speman®, A Proprietary Ayurvedic Formulation, Reverses Cyclophosphamide-Induced Oligospermia In Rats. ( 29755867 )
2013
37
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. ( 23732668 )
2013
38
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. ( 22905450 )
2012
39
Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. ( 23162296 )
2012
40
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. ( 21918533 )
2012
41
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 23141270 )
2012
42
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 22378155 )
2012
43
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). ( 21382069 )
2011
44
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. ( 20078516 )
2010
45
Azoospermia and severe oligospermia in testicular cancer. ( 19499754 )
2009
46
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. ( 19338535 )
2009
47
[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. ( 20218307 )
2009
48
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. ( 18555230 )
2008
49
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 17941933 )
2008
50
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. ( 18097510 )
2008

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(20;22)(q13.3;q11.2) Translocation Uncertain significance
2 46;XY;t(12;14)(q15;q13)mat Translocation Uncertain significance
3 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh37 Chromosome 2, 176959246: 176959246
4 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh38 Chromosome 2, 176094518: 176094518

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.98 AR GSTM1 KITLG NFKB1
2
Show member pathways
10.96 AR NFKB1 SRD5A2

GO Terms for Oligospermia

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spermatogenesis GO:0007283 9.46 AR KLHL10 TSSK4 UBR2
2 fertilization GO:0009566 9.37 AR KLHL10
3 mammary gland development GO:0030879 9.32 PRL PYGO2
4 sex differentiation GO:0007548 9.26 AR SRD5A2
5 cellular response to hormone stimulus GO:0032870 9.1 GNRHR
6 male genitalia morphogenesis GO:0048808 8.96 AR KLHL10
7 male gonad development GO:0008584 8.92 AR KITLG KLHL10 SRD5A2

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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