MCID: OLG001
MIFTS: 45

Oligospermia

Categories: Reproductive diseases

Aliases & Classifications for Oligospermia

MalaCards integrated aliases for Oligospermia:

Name: Oligospermia 12 29 6 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD9CM 34 606.1
MeSH 44 D009845
NCIt 50 C34860
ICD10 32 N46.1
UMLS 70 C0028960

Summaries for Oligospermia

Disease Ontology : 12 A male fertility issue defined as a low sperm concentration in the ejaculate.

MalaCards based summary : Oligospermia is related to azoospermia and infertility. An important gene associated with Oligospermia is MSH4 (MutS Homolog 4), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Levoleucovorin and Inositol have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and pituitary, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 73 Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of... more...

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 azoospermia 31.6 MSH4 KLHL10 CFTR AR
2 infertility 31.2 PRL KLHL10 GNRHR EPPIN CFTR AR
3 varicocele 31.1 PRL GSTM1 FAM47C AR
4 male infertility 30.7 PRL KLHL10 KITLG KIT HOXD13 GSTM1
5 testicular cancer 30.3 KITLG GSTP1 GSTM1 AR
6 alopecia 30.3 SRD5A2 PRL AR
7 gynecomastia 30.3 SRD5A2 PRL AR
8 sexual disorder 30.2 PRL EPPIN AR
9 premature menopause 29.9 PRL MSH4 KITLG GNRHR EPPIN AR
10 cryptorchidism, unilateral or bilateral 29.7 SRD5A2 PRL KITLG KIT GNRHR EPPIN
11 y chromosome infertility 11.3
12 spermatogenic failure, y-linked, 2 11.1
13 bronchiectasis oligospermia 11.0
14 spermatogenic failure 4 10.9
15 androgen insensitivity, partial 10.9
16 penis agenesis 10.4 SRD5A2 AR
17 acrokeratoderma, hereditary papulotranslucent 10.4 PRL CFTR
18 androgenic alopecia 10.4 SRD5A2 PRL AR
19 transsexualism 10.4 SRD5A2 AR
20 prostatic hyperplasia, benign 10.4 SRD5A2 AR
21 extracutaneous mastocytoma 10.4 KITLG KIT
22 alopecia, androgenetic, 1 10.4 SRD5A2 AR
23 cutaneous solitary mastocytoma 10.4 KITLG KIT
24 oligoasthenoteratozoospermia 10.4 GSTP1 GSTM1 AR
25 sm-ahnmd 10.3 KITLG KIT
26 alcoholic pancreatitis 10.3 GSTP1 GSTM1 CFTR
27 mast-cell sarcoma 10.3 KITLG KIT
28 hypogonadotropic hypogonadism 23 without anosmia 10.3 GNRHR EPPIN
29 male infertility with azoospermia or oligozoospermia due to single gene mutation 10.3 KLHL10 CFTR
30 testicular germ cell cancer 10.3 KITLG KIT AR
31 germ cell cancer 10.3 KITLG KIT AR
32 testicular germ cell tumor 10.3 KITLG KIT AR
33 germinoma 10.3 PRL MIR122 KIT
34 prostatic hypertrophy 10.3 SRD5A2 EPPIN AR
35 ovarian gonadoblastoma 10.3 PRL KIT
36 dysgerminoma of ovary 10.3 KITLG KIT
37 hypospadias 10.3 SRD5A2 HOXD13 AR
38 partial deletion of y 10.3
39 lung leiomyosarcoma 10.3 KITLG KIT
40 pseudohermaphroditism 10.3 SRD5A2 EPPIN AR
41 anterior cerebral artery infarction 10.3 PRL KITLG
42 testicular disease 10.2 KITLG KIT EPPIN AR
43 disorder of sexual development 10.2 SRD5A2 PRL GNRHR EPPIN AR
44 impotence 10.2
45 hypogonadism 10.2
46 spermatogenic failure 50 10.1
47 ovarian benign neoplasm 10.1 PRL EPPIN
48 skin carcinoma 10.1 NFKB1 KITLG KIT GSTP1 GSTM1 AR
49 hypogonadotropic hypogonadism 10.1
50 renal hypodysplasia/aplasia 1 10.0 HOXD13 GNRHR CFTR

Comorbidity relations with Oligospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 AR CFTR GNRHR HOXD13 KIT KITLG
2 growth/size/body region MP:0005378 10.1 AR CFTR GNRHR GSTP1 HOXD13 KIT
3 digestive/alimentary MP:0005381 10.02 AR CFTR GNRHR HOXD13 KIT KITLG
4 integument MP:0010771 9.85 AR GNRHR GSTP1 HOXD13 KIT KITLG
5 liver/biliary system MP:0005370 9.5 AR CFTR KIT KITLG NFKB1 PRL
6 reproductive system MP:0005389 9.44 AR CFTR GNRHR HOXD13 KIT KITLG

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2 149436
2
Inositol Approved, Investigational, Withdrawn Phase 2, Phase 3 87-89-8
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
5
Polyestradiol phosphate Approved Phase 3 28014-46-2
6
Testosterone Approved, Investigational Phase 3 58-22-0 6013
7
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
9 Trace Elements Phase 2, Phase 3
10 Nutrients Phase 2, Phase 3
11 Vitamins Phase 2, Phase 3
12 Micronutrients Phase 2, Phase 3
13 Vitamin B9 Phase 2, Phase 3
14 Hematinics Phase 2, Phase 3
15 Vitamin B Complex Phase 2, Phase 3
16 Folate Phase 2, Phase 3
17 Estrogens Phase 3
18 Hormone Antagonists Phase 3
19 Antineoplastic Agents, Hormonal Phase 3
20 Estrogen Receptor Antagonists Phase 3
21 Hormones Phase 3
22 Aromatase Inhibitors Phase 3
23 Estrogen Antagonists Phase 3
24 Estradiol 3-benzoate Phase 3
25 Estradiol 17 beta-cypionate Phase 3
26
Lisinopril Approved, Investigational Phase 2 83915-83-7, 76547-98-3 5362119
27 Angiotensin-Converting Enzyme Inhibitors Phase 2
28
protease inhibitors Phase 2
29 HIV Protease Inhibitors Phase 2
30 Antihypertensive Agents Phase 2
31 Cardiotonic Agents Phase 2
32 Protective Agents Phase 2
33
Ethanol Approved 64-17-5 702
34
Papaverine Approved, Investigational 61-25-6, 58-74-2 4680
35 English walnut Approved
36
Ramipril Approved 87333-19-5 5362129
37
Coenzyme Q10 Approved, Investigational, Nutraceutical 303-98-0 5281915
38 carnitine
39 Omega 3 Fatty Acid
40 Ubiquinone
41 insulin
42 Insulin, Globin Zinc
43 Anesthetics
44 Antioxidants

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Effectiveness and Safety of uFSH for Severe Oligospermia or Azoospermia:A Multi-center,Open,Randomized,Interventional,and Phase4 Trial in China Unknown status NCT02307994 Phase 4 75IU uFSH
2 7 NUTS Study . A Randomized Dietary Intervention Trial on the Influence of Diet on Human Sperm Quality in Subfertile Men. Unknown status NCT02063256 Phase 2, Phase 3
3 Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing IVF Cycles Completed NCT01828710 Phase 2, Phase 3
4 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
5 The Role of Aromatase Inhibitors in the Treatment of Infertility in Obese Male Terminated NCT00440180 Phase 3 Anastrozole;Placebo
6 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
7 Safety and Efficacy of Chandrakanthi Choornam in Oligospermia - A Preclinical and Clinical Study Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
8 A 5-year Prospective, Placebo-controlled, Crossover Evaluation of the Efficacy and Tolerability of Low-dose Lisinopril in Normotensives With Idiopathic Oligospermic Infertility Completed NCT01409837 Phase 2 Lisinopril
9 Efficiency Evaluation of Adipose-Derived Adult Stromal Vascular Cells in Patients With Spermatogenesis Disorders. Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
10 Effect of Dietary Supplementation With Omega-3 Fatty Acids on Human Sperm Characteristics, a Preliminary Study Unknown status NCT00479960 Early Phase 1
11 Vitamins ,Minerals and Amino Acids Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality. A Double Blind Randomized Controlled Trial Unknown status NCT01520584
12 Omega-3 Polyunsaturated Fatty Acids for the Treatment of Patients With Idiopathic Oligoasthenoteratospermia: A Double-blind, Placebo-controlled and Randomized Exploratory Clinical Trial Unknown status NCT03634644 Omega 3 fatty acid;Placebo oral capsule
13 Investigating the Effect of Modifiable Lifestyle Factors in Severe Oligoasthenotertozoospermic Men Combined With Antioxidant Treatment Prior ICSI Unknown status NCT02752555
14 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173
15 Is Oxidative Stress in Semen Reduced by Lifestyle Intervention Completed NCT03898752
16 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
17 Seminal Fluid's Changes Over Time: a Single Center 20 Years Experience Completed NCT04349345
18 Genetic Studies Spermatogenic Failure Completed NCT00548977
19 Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum) Completed NCT00044369
20 Does COVID-19 Worsen the Semen Parameters? Early Results of a Tertiary Health Center Completed NCT04643522
21 A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome Completed NCT03594201
22 Insulin Resistance : a New Diagnosis of the Pathogenesis of Idiopathic Oligozoospermia and Non Obstructive Azoospermia Completed NCT01509482
23 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia; A Randomized Controlled Study Completed NCT03344588
24 Effect of Walnuts on Sperm Parameters and Male Fertility Completed NCT01954498
25 Embryo Kinetics and Sperm Quality. Depends on the Sperm Quality the Embryo Cleavage Rate? Completed NCT02155179
26 Evaluation of the Clinical Treatments in Men With Severe Oligospermia, ICSI Failures and High DNA Fragmentation With the Use of Testicular Sperm Recruiting NCT04795440
27 Impact of Immunotherapy in the Spermogram Recruiting NCT04554030
28 Does Antioxidant Administration Improve Sperm Quality in Infertile Men Not yet recruiting NCT04256278
29 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions on the Human Y Chromosome in Infertile Male Patients Suspended NCT03497728
30 Ramipril for the Treatment of Oligospermia: A Double-Blind Randomized Control Trial Terminated NCT01856361 Ramipril;Placebo

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

# Genetic test Affiliating Genes
1 Oligospermia 29

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

40
Testis, Testes, Pituitary, Thyroid, Ovary, Prostate, Bone Marrow

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 1350)
# Title Authors PMID Year
1
Rare missense variant in MSH4 associated with primary gonadal failure in both 46, XX and 46, XY individuals. 6
33448284 2021
2
Prevalence of Hyperprolactinemia and Clinically Apparent Prolactinomas in Men Undergoing Fertility Evaluation. 61
33766719 2021
3
The evaluation of Human papilloma virus and human herpes viruses (EBV, CMV, VZV HSV-1 and HSV-2) in semen samples. 61
33774857 2021
4
RNA N6-methyladenosine modification, spermatogenesis, and human male infertility. 61
33749751 2021
5
Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. 61
33784440 2021
6
Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats. 61
33793798 2021
7
[Recommendations of the Committee of Andrology and Sexual Medicine of the AFU concerning the management of Varicocele]. 61
33308982 2021
8
Contribution of amniotic membrane to the healing of iatrogenic vas deferens injury. 61
33726480 2021
9
Counteracting effects of heavy metals and antioxidants on male fertility. 61
33761043 2021
10
The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, Before and After Freezing in Oligospermia Men. 61
33550580 2021
11
Association between a marker of sperm DNA damage and sperm indices in infertile males in Benin City, Nigeria: A cross-sectional study. 61
33718758 2021
12
Y chromosome microdeletion and cytogenetic findings in male infertility: A cross-sectional descriptive study. 61
33718759 2021
13
Identification and Analysis of a Novel NR0B1 Mutation in Late-Onset Adrenal Hypoplasia Congenita and Hypogonadism. 61
33381670 2021
14
Increased Mortality Among Men Diagnosed With Impaired Fertility: Analysis of US Claims Data. 61
33017614 2021
15
Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis. 61
33708220 2021
16
A different look at genetic factors in individuals with non-obstructive azoospermia or oligospermia in our research study: To whom, which threshold, when, in what way? 61
32061499 2021
17
NMR-based metabolomics approach to study the effects of Wu-Zi-Yan-Zong-Wan on triptolide-induced oligospermia in rats. 61
32889033 2021
18
Cystatin C and Seminal Parameter Evaluation in Patients with End-Stage Renal Disease. 61
33488335 2020
19
A genomics approach to male infertility. 61
32719396 2020
20
The Effect of Varicocelectomy on the Pregnancy Rate in Patients with Severe Oligospermia. 61
33355829 2020
21
rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population. 61
32827681 2020
22
Primary and secondary infertility in Africa: systematic review with meta-analysis. 61
33292584 2020
23
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. 61
33383876 2020
24
[Risk of Male Infertility Due to Testosterone Replacement Therapy for Late-Onset Hypogonadism (LOH)]. 61
33271659 2020
25
Adult survivors of idiopathic childhood onset nephrotic syndrome. 61
33155129 2020
26
Cytogenetic and molecular study of 370 infertile men in South India highlighting the importance of copy number variations by multiplex ligation-dependent probe amplification. 61
32790203 2020
27
Four-week repeated dose oral toxicity study of KDS2010, a novel selective monoamine oxidase B inhibitor, in Sprague Dawley rats. 61
32758522 2020
28
Aripiprazole-Associated Oligospermia. 61
33021544 2020
29
Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial. 61
33095756 2020
30
Is there any relationship between human sperm parameters and protamine deficiency in different groups of infertile men? 61
31326281 2020
31
Testicular stiffness in varicocele: evaluation with shear wave elastography. 61
32326674 2020
32
A Role for Chromosomal Microarray Testing in the Workup of Male Infertility. 61
32615168 2020
33
CHD7 missense variants and clinical characteristics of Chinese males with infertility. 61
32573075 2020
34
ABVD and BEACOPP regimens' effects on fertility in young males with Hodgkin lymphoma. 61
32944834 2020
35
A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents. 61
32554749 2020
36
Whole-exome sequencing of a large Chinese azoospermia and severe oligospermia cohort identifies novel infertility causative variants and genes. 61
32469048 2020
37
Intronic variation of the SOHLH2 gene confers risk to male reproductive impairment. 61
32690270 2020
38
Photobiomodulation restores spermatogenesis in the transient scrotal hyperthermia-induced mice. 61
32407848 2020
39
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice. 61
32416107 2020
40
Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility. 61
31603142 2020
41
Associations of Common Single Nucleotide Polymorphisms in miR-34b/c and miR-499 with Male Infertility Caused by Oligospermia or Azoospermia in the Chinese Population. 61
32412799 2020
42
[Research progress of proteins related to sperm tail development]. 61
32694111 2020
43
[Novel compound heterozygous LoF mutations in SRD5A2 may result in disorders of sex development]. 61
32536088 2020
44
Indian Sarsaparilla (Hemidesmus indicus): Recent progress in research on ethnobotany, phytochemistry and pharmacology. 61
32007632 2020
45
First custom next-generation sequencing infertility panel in Latin America: design and first results. 61
32155011 2020
46
A clinical algorithm for management of fertility in adolescents with the Klinefelter syndrome. 61
32235276 2020
47
Cryopreservation of single-sperm: where are we today? 61
32398019 2020
48
Determination of 27 amino acids' levels in seminal plasma of asthenospermia and oligospermia patients and diagnostic value analysis. 61
32126460 2020
49
Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: Role of JNK/caspase-3 signaling inhibition. 61
32059174 2020
50
Studies on the toxic effects of agrochemical pesticide (Monocrotophos) on physiological and reproductive behavior of indigenous and exotic earthworm species. 61
30897939 2020

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 KIF3B NM_004798.4(KIF3B):c.1032A>T (p.Pro344=) SNV association 830043 GRCh37: 20:30898612-30898612
GRCh38: 20:32310809-32310809
2 MSH4 NM_002440.4(MSH4):c.2261C>T (p.Ser754Leu) SNV Pathogenic 869115 rs377712900 GRCh37: 1:76356415-76356415
GRCh38: 1:75890730-75890730
3 HOXD13 NM_000523.4(HOXD13):c.820C>T (p.Arg274Ter) SNV Pathogenic 374019 rs200750564 GRCh37: 2:176959246-176959246
GRCh38: 2:176094518-176094518
4 TBC1D25 NM_002536.4(TBC1D25):c.4609C>T SNV Likely pathogenic 816940 rs1602125411 GRCh37: X:48421905-48421905
GRCh38: X:48563517-48563517

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 SRD5A2 NFKB1 KIT GSTP1 AR
2 11.83 NFKB1 KITLG KIT GSTP1 GSTM1 AR
3 11.02 KITLG KIT GSTM1
4 10.46 KITLG KIT

GO Terms for Oligospermia

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spermatogenesis GO:0007283 9.8 UBR2 MSH4 KLHL10 KIT AR
2 spermatid development GO:0007286 9.61 PYGO2 KLHL10 KIT
3 embryonic hemopoiesis GO:0035162 9.48 KITLG KIT
4 male genitalia development GO:0030539 9.46 SRD5A2 HOXD13
5 hepoxilin biosynthetic process GO:0051122 9.37 GSTP1 GSTM1
6 ovarian follicle development GO:0001541 9.33 MSH4 KITLG KIT
7 ectopic germ cell programmed cell death GO:0035234 9.32 KITLG KIT
8 male genitalia morphogenesis GO:0048808 9.26 KLHL10 AR
9 male gonad development GO:0008584 9.02 SRD5A2 KLHL10 KITLG KIT AR
10 morphogenesis of an epithelial fold GO:0060571 8.96 HOXD13 AR

Molecular functions related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione binding GO:0043295 8.62 GSTP1 GSTM1

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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