MCID: OLG001
MIFTS: 40

Oligospermia

Categories: Reproductive diseases

Aliases & Classifications for Oligospermia

MalaCards integrated aliases for Oligospermia:

Name: Oligospermia 12 29 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD10 33 N46.1 N46.11
ICD9CM 35 606.1
MeSH 44 D009845
NCIt 50 C34860
UMLS 73 C0028960

Summaries for Oligospermia

MalaCards based summary : Oligospermia is related to spermatogenic failure, y-linked, 2 and azoospermia. An important gene associated with Oligospermia is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Fluid shear stress and atherosclerosis. The drugs Metformin and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and testis, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 76 Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of... more...

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure, y-linked, 2 32.0 DAZ1 DAZ4
2 azoospermia 31.1 AR DAZ1 DAZ4
3 infertility 30.7 DAZ1 DAZ4 PRL
4 varicocele 30.6 GSTM1 GSTT1 PRL
5 male infertility 30.2 AR CFTR DAZ1 DAZ4
6 bronchiectasis oligospermia 12.1
7 y chromosome infertility 11.4
8 androgen insensitivity, partial 11.1
9 androgenic alopecia 10.2 AR PRL
10 sex differentiation disease 10.2 AR PRL
11 johanson-blizzard syndrome 10.1 CFTR UBR2
12 partial deletion of y 10.1 DAZ1 DAZ4
13 hypogonadotropism 10.1 GNRHR PRL
14 spermatogenic failure, x-linked, 1 10.1 DAZ1 DAZ4
15 hearing loss, noise-induced 10.1 GSTM1 GSTT1
16 sister chromatid exchange, frequency of 10.1 GSTM1 GSTT1
17 impotence 10.1
18 psoriasis 10.1
19 bronchiectasis 10.1
20 isolated cleft lip 10.1 GSTM1 GSTT1
21 oral leukoplakia 10.1 GSTM1 GSTT1
22 leukoplakia 10.1 GSTM1 GSTT1
23 oligoasthenoteratozoospermia 10.1 AR GSTM1
24 drug-induced hepatitis 10.1 GSTM1 GSTT1
25 cardia cancer 10.1 GSTM1 GSTT1
26 mutagen sensitivity 10.1 GSTM1 GSTT1
27 arteritic anterior ischemic optic neuropathy 10.0 GSTM1 GSTT1
28 ischemic optic neuropathy 10.0 GSTM1 GSTT1
29 male reproductive system disease 10.0 AR DAZ1 DAZ4
30 gonadal disease 10.0 AR GNRHR PRL
31 senile cataract 10.0 GSTM1 GSTT1
32 diffuse gastric cancer 10.0 GSTM1 GSTT1
33 testicular germ cell cancer 10.0 AR KITLG
34 laryngeal disease 10.0 GSTM1 GSTT1
35 autoimmune pancreatitis 10.0 CFTR UBR2
36 xeroderma pigmentosum, complementation group d 10.0 GSTM1 GSTT1
37 asbestosis 10.0 GSTM1 GSTT1
38 cryptorchidism, unilateral or bilateral 10.0 AR DAZ1 GNRHR
39 schizophrenia 9.9
40 gynecomastia 9.9
41 hypogonadism 9.9
42 testicular cancer 9.9
43 hyperglycemia 9.9
44 hypereosinophilic syndrome 9.9
45 pustular psoriasis 9.9
46 ring chromosome 12 9.9
47 reproductive system disease 9.9 AR DAZ1 DAZ4 PRL
48 scabies 9.9 GSTM1 KITLG
49 oral submucous fibrosis 9.8 GSTM1 GSTT1
50 aplastic anemia 9.6 GSTM1 GSTT1 KITLG

Comorbidity relations with Oligospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 AR CFTR GNRHR KITLG KLHL10 NFKB1
2 digestive/alimentary MP:0005381 9.73 AR CFTR GNRHR KITLG NFKB1 PYGO2
3 craniofacial MP:0005382 9.72 AR CFTR KITLG NFKB1 PYGO2
4 integument MP:0010771 9.43 AR GNRHR KITLG NFKB1 PRL PYGO2
5 reproductive system MP:0005389 9.23 AR CFTR GNRHR KITLG KLHL10 PRL

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
3
Enclomiphene Investigational Phase 4,Phase 3 15690-57-0
4 Citrate Phase 4,Phase 3
5 Clomiphene Phase 4,Phase 3
6 insulin Phase 4,Not Applicable
7 Estrogen Antagonists Phase 4,Phase 3
8 Chorionic Gonadotropin Phase 4
9 Zuclomiphene Phase 4,Phase 3
10 Estrogen Receptor Antagonists Phase 4,Phase 3
11 Estrogen Receptor Modulators Phase 4,Phase 3
12 Fertility Agents Phase 4,Phase 3
13 Hormones Phase 4,Phase 3
14 Selective Estrogen Receptor Modulators Phase 4,Phase 3
15 Anticoagulants Phase 4,Phase 3
16 Estrogens Phase 4,Phase 3
17 Hormone Antagonists Phase 4,Phase 3
18 Insulin, Globin Zinc Phase 4,Not Applicable
19 Hypoglycemic Agents Phase 4,Not Applicable
20 Calcium, Dietary Phase 4,Phase 3,Phase 2
21 Chelating Agents Phase 4,Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
23
Testosterone enanthate Approved Phase 3 315-37-7 9416
24
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
25
Methyltestosterone Approved Phase 3 58-18-4 6010
26
Testosterone Approved, Investigational Phase 3 58-22-0 6013
27
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
28
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
29 Ginger Approved Phase 3
30 English walnut Approved Phase 2, Phase 3
31
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
32
Polyestradiol phosphate Approved Phase 3 28014-46-2
33 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
34
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
36 Testosterone 17 beta-cypionate Phase 3
37 Trace Elements Phase 2, Phase 3,Not Applicable
38 Micronutrients Phase 2, Phase 3,Not Applicable
39 Vitamins Phase 2, Phase 3,Not Applicable
40 Aromatase Inhibitors Phase 3
41 Steroid Synthesis Inhibitors Phase 3
42 Vitamin B9 Phase 2, Phase 3
43 Vitamin B Complex Phase 2, Phase 3
44 Hematinics Phase 2, Phase 3
45 Folate Phase 2, Phase 3
46 Sweet Basil Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Estradiol 17 beta-cypionate Phase 3
49 Androgens Phase 3
50 Estradiol 3-benzoate Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Unknown status NCT02998593 Phase 3 Bahman capsules;Placebo
5 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
6 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
7 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
8 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
9 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
10 Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Not yet recruiting NCT03615547 Phase 3 Clomifene Citrate
11 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
12 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
13 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
14 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
15 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
16 Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
17 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
18 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584 Not Applicable
19 Severe Male Factor Infertility Management Unknown status NCT02752555 Not Applicable
20 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173 Not Applicable
21 Preimplantation Genetic Screening in Patients With Male Factor Infertility Unknown status NCT02941965 Not Applicable
22 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
23 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799 Not Applicable
24 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482 Not Applicable
25 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588 Not Applicable
26 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
27 Genetic Studies Spermatogenic Failure Completed NCT00548977
28 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Not Applicable Mesenchymal stem cell injection
29 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
30 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
31 A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome Completed NCT03594201
32 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
33 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
34 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Recruiting NCT03497728
35 Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia Recruiting NCT03634644 Not Applicable Omega 3 fatty acid;Placebo oral capsule
36 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Recruiting NCT02932527 Not Applicable
37 Fertility Preservation in Cases of Klinefelter Syndrome. Active, not recruiting NCT01918280 Not Applicable
38 Serum and Semen Vitamin D Level With Semen Parameters Not yet recruiting NCT03477136
39 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Not Applicable Ramipril;Placebo

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

# Genetic test Affiliating Genes
1 Oligospermia 29

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

41
Bone, Pituitary, Testis, Testes

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 195)
# Title Authors Year
1
NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study. ( 29942932 )
2018
2
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity. ( 29739640 )
2018
3
Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology. ( 29051002 )
2018
4
Microscopic varicocelectomy as a treatment option for patients with severe oligospermia. ( 29744475 )
2018
5
Time to improvement in semen parameters after microsurgical varicocelectomy in men with severe oligospermia. ( 30169150 )
2018
6
Re: Men with Severe Oligospermia Appear to Benefit from Varicocele Repair: A Cost-Effectiveness Analysis of Assisted Reproductive Technology. ( 30412957 )
2018
7
Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. ( 28444774 )
2017
8
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. ( 28367414 )
2017
9
Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia. ( 29404532 )
2017
10
Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. ( 28730893 )
2017
11
Re: Higher Pregnancy Rates Using Testicular Sperm in Men with Severe Oligospermia. ( 27597099 )
2016
12
Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ( 26940145 )
2016
13
A novel nomogram for prediction of spermatogenic improvement following empiric medical therapy for moderate-severe oligospermia. ( 26892053 )
2016
14
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia. ( 27812445 )
2016
15
A Role for Heterozygosity of NF-d998B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia. ( 27041523 )
2016
16
Higher pregnancy rates using testicular sperm in men with severe oligospermia. ( 26363389 )
2015
17
Re: Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25986825 )
2015
18
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. ( 26345837 )
2015
19
Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China. ( 25532576 )
2014
20
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: aA randomized phase II clinical trial comparing topical testosterone. ( 25044085 )
2014
21
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia. ( 25109708 )
2014
22
Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia. ( 25536748 )
2014
23
Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. ( 24756080 )
2014
24
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. ( 24369145 )
2014
25
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. ( 25106941 )
2014
26
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. ( 24631383 )
2014
27
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. ( 24083421 )
2013
28
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. ( 23885232 )
2013
29
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. ( 24002933 )
2013
30
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. ( 24034937 )
2013
31
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. ( 23384712 )
2013
32
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. ( 23732668 )
2013
33
Speman®, A Proprietary Ayurvedic Formulation, Reverses Cyclophosphamide-Induced Oligospermia In Rats. ( 29755867 )
2013
34
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. ( 22905450 )
2012
35
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. ( 21918533 )
2012
36
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 23141270 )
2012
37
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 22378155 )
2012
38
Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. ( 23162296 )
2012
39
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). ( 21382069 )
2011
40
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. ( 20078516 )
2010
41
Azoospermia and severe oligospermia in testicular cancer. ( 19499754 )
2009
42
[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. ( 20218307 )
2009
43
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. ( 19338535 )
2009
44
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. ( 18097510 )
2008
45
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 18399835 )
2008
46
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. ( 19062477 )
2008
47
Ring chromosome 12 and severe oligospermia: a case report. ( 17880954 )
2008
48
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 17941933 )
2008
49
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. ( 18555230 )
2008
50
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? ( 17982752 )
2008

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh37 Chromosome 2, 176959246: 176959246
2 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh38 Chromosome 2, 176094518: 176094518

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.74 AR GSTM1 GSTT1 KITLG NFKB1
2 11.27 GSTM1 GSTT1 NFKB1
3 10.72 GSTM1 GSTT1
4 10.54 GSTM1 GSTT1

GO Terms for Oligospermia

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.46 GSTM1 GSTT1
2 fertilization GO:0009566 9.43 AR KLHL10
3 germ cell development GO:0007281 9.4 DAZ1 DAZ4
4 mammary gland development GO:0030879 9.37 PRL PYGO2
5 spermatogenesis GO:0007283 9.35 AR DAZ1 DAZ4 KLHL10 UBR2
6 male gonad development GO:0008584 9.33 AR KITLG KLHL10
7 glutathione derivative biosynthetic process GO:1901687 9.32 GSTM1 GSTT1
8 positive regulation of translational initiation GO:0045948 9.26 DAZ1 DAZ4
9 male genitalia morphogenesis GO:0048808 8.62 AR KLHL10

Molecular functions related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
2 translation activator activity GO:0008494 8.62 DAZ1 DAZ4

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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