Aliases & Classifications for Oligospermia

MalaCards integrated aliases for Oligospermia:

Name: Oligospermia 12 29 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD10 33 N46.1 N46.11
ICD9CM 35 606.1
MeSH 44 D009845
NCIt 50 C34860
UMLS 73 C0028960

Summaries for Oligospermia

MalaCards based summary : Oligospermia is related to spermatogenic failure, y-linked, 2 and azoospermia. An important gene associated with Oligospermia is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Metformin and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and pituitary, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 76 Terms oligospermia and oligozoospermia refer to semen with a low concentration of sperm and is a common... more...

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure, y-linked, 2 31.6 DAZ1 DAZ4
2 azoospermia 30.4 AR DAZ1 DAZ4
3 varicocele 30.4 GSTM1 GSTT1 PRL
4 infertility 30.0 DAZ1 DAZ4 PRL
5 gynecomastia 29.4 AR PRL
6 male infertility 29.1 AR CFTR DAZ1 DAZ4
7 bronchiectasis oligospermia 11.9
8 y chromosome infertility 11.2
9 androgen insensitivity, partial 10.9
10 androgenic alopecia 10.5 AR PRL
11 sex differentiation disease 10.5 AR PRL
12 hearing loss, noise-induced 10.4 GSTM1 GSTT1
13 johanson-blizzard syndrome 10.4 CFTR UBR2
14 sister chromatid exchange, frequency of 10.4 GSTM1 GSTT1
15 isolated cleft lip 10.4 GSTM1 GSTT1
16 hypogonadotropism 10.4 GNRHR PRL
17 drug-induced hepatitis 10.3 GSTM1 GSTT1
18 leukoplakia 10.3 GSTM1 GSTT1
19 mutagen sensitivity 10.3 GSTM1 GSTT1
20 testicular germ cell cancer 10.3 AR KITLG
21 arteritic anterior ischemic optic neuropathy 10.3 GSTM1 GSTT1
22 senile cataract 10.2 GSTM1 GSTT1
23 diffuse gastric cancer 10.2 GSTM1 GSTT1
24 asbestosis 10.2 GSTM1 GSTT1
25 xeroderma pigmentosum, complementation group d 10.1 GSTM1 GSTT1
26 partial deletion of y 10.1 DAZ1 DAZ4
27 cervicitis 10.0
28 ischemic optic neuropathy 10.0 GSTM1 GSTT1
29 scabies 10.0 GSTM1 KITLG
30 spermatogenic failure, x-linked, 1 10.0 DAZ1 DAZ4
31 impotence 9.9
32 psoriasis 9.9
33 bronchiectasis 9.9
34 oral submucous fibrosis 9.9 GSTM1 GSTT1
35 schizophrenia 9.8
36 aging 9.8
37 hypogonadism 9.8
38 testicular cancer 9.8
39 hyperglycemia 9.8
40 epididymitis 9.8
41 hypereosinophilic syndrome 9.8
42 transmitted_by 9.8
43 pustular psoriasis 9.8
44 ring chromosome 12 9.8
45 cryptorchidism, unilateral or bilateral 9.6 AR DAZ1 GNRHR
46 male reproductive system disease 9.4 AR CFTR DAZ1 DAZ4
47 aplastic anemia 9.3 GSTM1 GSTT1 KITLG
48 reproductive system disease 8.9 AR CFTR DAZ1 DAZ4 PRL

Comorbidity relations with Oligospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 AR CFTR GNRHR KITLG KLHL10 PRL
2 reproductive system MP:0005389 9.23 KLHL10 PRL PYGO2 UBR2 AR CFTR

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
3
Enclomiphene Investigational Phase 4 15690-57-0
4 Anticoagulants Phase 4
5 Calcium, Dietary Phase 4,Phase 2
6 Chelating Agents Phase 4
7 Chorionic Gonadotropin Phase 4
8 Clomiphene Phase 4
9 Estrogen Antagonists Phase 4,Phase 3
10 Estrogen Receptor Modulators Phase 4
11 Estrogens Phase 4,Phase 3
12 Fertility Agents Phase 4
13 Hormone Antagonists Phase 4,Phase 3
14 Hormones Phase 4,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
16 Hypoglycemic Agents Phase 4,Not Applicable
17 insulin Phase 4,Not Applicable
18 Insulin, Globin Zinc Phase 4,Not Applicable
19 Selective Estrogen Receptor Modulators Phase 4
20 Zuclomiphene Phase 4
21 Citrate Nutraceutical Phase 4
22
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
23
Methyltestosterone Approved Phase 3 58-18-4 6010
24
Testosterone Approved, Investigational Phase 3 58-22-0 6013
25
Testosterone enanthate Approved Phase 3 315-37-7 9416
26
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
27
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
28 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
29
Menthol Approved Phase 3 2216-51-5 16666
30
Polyestradiol phosphate Approved Phase 3 28014-46-2
31
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 143 6006
34 Ginger Approved, Nutraceutical Phase 3
35 English walnut Approved, Nutraceutical Phase 2, Phase 3
36 Micronutrients Phase 2, Phase 3,Not Applicable
37 Trace Elements Phase 2, Phase 3,Not Applicable
38 Vitamins Phase 2, Phase 3,Not Applicable
39 Aromatase Inhibitors Phase 3
40 Steroid Synthesis Inhibitors Phase 3
41 Hematinics Phase 2, Phase 3
42 Vitamin B Complex Phase 2, Phase 3
43 Testosterone 17 beta-cypionate Phase 3
44 Anabolic Agents Phase 3
45 Androgens Phase 3
46 Antineoplastic Agents, Hormonal Phase 3
47 Estradiol 17 beta-cypionate Phase 3
48 Estradiol 3-benzoate Phase 3
49 Folate Nutraceutical Phase 2, Phase 3
50 Vitamin B9 Nutraceutical Phase 2, Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
5 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
6 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
7 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
8 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Recruiting NCT02998593 Phase 3 Bahman capsules;Placebo
9 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
10 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
11 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
12 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
13 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
14 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
15 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
16 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584 Not Applicable
17 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173 Not Applicable
18 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
19 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799 Not Applicable
20 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482 Not Applicable
21 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588 Not Applicable
22 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
23 Genetic Studies Spermatogenic Failure Completed NCT00548977
24 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Not Applicable Mesenchymal stem cell injection
25 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
26 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
27 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
28 Severe Male Factor Infertility Management Recruiting NCT02752555 Not Applicable
29 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
30 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Recruiting NCT03497728
31 Fertility Preservation in Cases of Klinefelter Syndrome. Recruiting NCT01918280 Not Applicable
32 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Recruiting NCT02932527 Not Applicable
33 Preimplantation Genetic Screening in Patients With Male Factor Infertility Not yet recruiting NCT02941965 Not Applicable
34 Serum and Semen Vitamin D Level With Semen Parameters Not yet recruiting NCT03477136
35 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Not Applicable Ramipril;Placebo

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

# Genetic test Affiliating Genes
1 Oligospermia 29

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

41
Bone, Bone Marrow, Pituitary, Testis, Testes

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 190)
# Title Authors Year
1
NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study. ( 29942932 )
2018
2
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity. ( 29739640 )
2018
3
Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology. ( 29051002 )
2018
4
Microscopic varicocelectomy as a treatment option for patients with severe oligospermia. ( 29744475 )
2018
5
Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. ( 28444774 )
2017
6
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. ( 28367414 )
2017
7
Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia. ( 29404532 )
2017
8
Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. ( 28730893 )
2017
9
Re: Higher Pregnancy Rates Using Testicular Sperm in Men with Severe Oligospermia. ( 27597099 )
2016
10
Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ( 26940145 )
2016
11
A novel nomogram for prediction of spermatogenic improvement following empiric medical therapy for moderate-severe oligospermia. ( 26892053 )
2016
12
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia. ( 27812445 )
2016
13
A Role for Heterozygosity of NF-d998B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia. ( 27041523 )
2016
14
Higher pregnancy rates using testicular sperm in men with severe oligospermia. ( 26363389 )
2015
15
Re: Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25986825 )
2015
16
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. ( 26345837 )
2015
17
Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China. ( 25532576 )
2014
18
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: aA randomized phase II clinical trial comparing topical testosterone. ( 25044085 )
2014
19
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia. ( 25109708 )
2014
20
Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia. ( 25536748 )
2014
21
Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. ( 24756080 )
2014
22
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. ( 24369145 )
2014
23
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. ( 25106941 )
2014
24
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. ( 24631383 )
2014
25
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. ( 24083421 )
2013
26
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. ( 23885232 )
2013
27
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. ( 24002933 )
2013
28
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. ( 24034937 )
2013
29
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. ( 23384712 )
2013
30
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. ( 23732668 )
2013
31
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. ( 22905450 )
2012
32
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. ( 21918533 )
2012
33
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 23141270 )
2012
34
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 22378155 )
2012
35
Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. ( 23162296 )
2012
36
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). ( 21382069 )
2011
37
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. ( 20078516 )
2010
38
Azoospermia and severe oligospermia in testicular cancer. ( 19499754 )
2009
39
[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. ( 20218307 )
2009
40
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. ( 19338535 )
2009
41
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. ( 18097510 )
2008
42
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 18399835 )
2008
43
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. ( 19062477 )
2008
44
Ring chromosome 12 and severe oligospermia: a case report. ( 17880954 )
2008
45
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 17941933 )
2008
46
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. ( 18555230 )
2008
47
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? ( 17982752 )
2008
48
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). ( 17218411 )
2007
49
[Clinical observation on treatment of oligospermia and asthenospermia with Liuwu Shengjing Decoction]. ( 18173142 )
2007
50
[Genetic polymorphism of glutathione S-transferase T1 associated with idiopathic azoospermia and oligospermia]. ( 17569254 )
2007

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(20;22)(q13.3;q11.2) Translocation Uncertain significance
2 46;XY;t(12;14)(q15;q13)mat Translocation Uncertain significance
3 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh37 Chromosome 2, 176959246: 176959246
4 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs200750564 GRCh38 Chromosome 2, 176094518: 176094518

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.18 AR GSTM1 GSTT1 KITLG
2 10.42 GSTM1 GSTT1
3 10 GSTM1 GSTT1

GO Terms for Oligospermia

Cellular components related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.65 AR CFTR DAZ1 DAZ4 GSTM1 GSTT1
2 protein-containing complex GO:0032991 8.92 AR CFTR DAZ1 DAZ4

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fertilization GO:0009566 9.46 AR KLHL10
2 germ cell development GO:0007281 9.43 DAZ1 DAZ4
3 mammary gland development GO:0030879 9.4 PRL PYGO2
4 glutathione derivative biosynthetic process GO:1901687 9.37 GSTM1 GSTT1
5 male gonad development GO:0008584 9.33 AR KITLG KLHL10
6 positive regulation of translational initiation GO:0045948 9.32 DAZ1 DAZ4
7 3-UTR-mediated mRNA stabilization GO:0070935 9.26 DAZ1 DAZ4
8 spermatogenesis GO:0007283 9.1 AR DAZ1 DAZ4 KLHL10 TSSK4 UBR2
9 male genitalia morphogenesis GO:0048808 8.96 AR KLHL10

Molecular functions related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 AR CFTR DAZ1 DAZ4 GSTM1 GSTT1
2 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
3 translation activator activity GO:0008494 8.62 DAZ1 DAZ4

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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