MCID: OMS001
MIFTS: 34

Omsk Hemorrhagic Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Omsk Hemorrhagic Fever

MalaCards integrated aliases for Omsk Hemorrhagic Fever:

Name: Omsk Hemorrhagic Fever 12 76 53 59 3 15
Hemorrhagic Fever, Omsk 44 73
Ohf 53 3

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:992
ICD10 33 A98.1
ICD9CM 35 065.1
MeSH 44 D006481
SNOMED-CT 68 48113006
Orphanet 59 ORPHA319266
UMLS via Orphanet 74 C0019103
ICD10 via Orphanet 34 A98.1
UMLS 73 C0019103

Summaries for Omsk Hemorrhagic Fever

NIH Rare Diseases : 53 Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is an infection that occurs primarily in the western Siberia regions of Omsk, Novosibirsk, Kurgan and Tyumen. People can become infected from tick bites, or from contact with the blood, feces, or urine of an infected or dead animal (most commonly a rodent who was infected by a tick). Human exposure may also occur from contaminated water, in a laboratory setting, or through the milk of infected goats or sheep. No person-to-person transmission has been documented. The first signs and symptoms of OHF may begin between 3 to 8 days after exposure and may include chills, fever, nausea, headache, and severe muscle pain. Other symptoms that may occur 3 to 4 days after the first symptoms begin include vomiting, other gastrointestinal problems, and bleeding problems. In rare cases, OHF can cause hearing loss, hair loss, and behavioral or psychological problems.   There is no specific treatment for OHF, but important aspects of management include hydration and taking usual precautions for people with bleeding disorders. Some people with OHF recover within 2 weeks with no complications. However, others experience a second episode of symptoms, including fever and encephalitis, about 3 weeks after the initial onset of symptoms. In up to 3% of people with OHF, the infection is fatal.

MalaCards based summary : Omsk Hemorrhagic Fever, also known as hemorrhagic fever, omsk, is related to hemorrhagic fever and encephalitis, and has symptoms including fever, chills and headache. An important gene associated with Omsk Hemorrhagic Fever is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are PEDF Induced Signaling and Integrin Pathway. Affiliated tissues include cerebellum.

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Omsk hemorrhagic fever virus, which is transmitted by Dermacentor and transmitted by Ixodes species of ticks. The infection has symptom fever, has symptom chills, has symptom headache, has symptom pain in lower and upper extremities, has symptom stiff neck, has symptom papulovesicular rash on the soft palate, has symptom cervical lymphadenopathy, has symptom conjunctival suffusion, has symptom blood in the urine, and has symptom blood in the sputum.

CDC : 3 Omsk hemorrhagic fever (OHF) is caused by Omsk hemorrhagic fever virus (OHFV), a member of the virus family Flaviviridae. OHF was described between 1945 and 1947 in Omsk, Russia from patients with hemorrhagic fever.

Wikipedia : 76 Omsk hemorrhagic fever is a viral hemorrhagic fever caused by a... more...

Related Diseases for Omsk Hemorrhagic Fever

Graphical network of the top 20 diseases related to Omsk Hemorrhagic Fever:



Diseases related to Omsk Hemorrhagic Fever

Symptoms & Phenotypes for Omsk Hemorrhagic Fever

Symptoms:

12
  • fever
  • chills
  • headache
  • pain in lower
  • stiff neck
  • papulovesicular rash on the soft palate
  • cervical lymphadenopathy
  • conjunctival suffusion
  • blood in the urine
  • blood in the sputum

Drugs & Therapeutics for Omsk Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Omsk Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, omsk

Genetic Tests for Omsk Hemorrhagic Fever

Anatomical Context for Omsk Hemorrhagic Fever

MalaCards organs/tissues related to Omsk Hemorrhagic Fever:

41
Cerebellum

Publications for Omsk Hemorrhagic Fever

Articles related to Omsk Hemorrhagic Fever:

# Title Authors Year
1
Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus. ( 24329534 )
2013
2
The deduced evolution history of Omsk hemorrhagic fever virus. ( 24259273 )
2013
3
Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5. ( 20817056 )
2011
4
Comparative analysis of immune responses to Russian spring-summer encephalitis and Omsk hemorrhagic fever viruses in mouse models. ( 20875909 )
2010
5
Sub-genomic replicon and virus-like particles of Omsk hemorrhagic fever virus. ( 19277843 )
2009
6
Structure of the envelope protein domain III of Omsk hemorrhagic fever virus. ( 16647096 )
2006
7
An animal model for the tickborne flavivirus--Omsk hemorrhagic fever virus. ( 15593010 )
2005
8
Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus. ( 12951023 )
2003
9
Electron microscopic study of the central nervous system in mice infected by Omsk hemorrhagic fever (OHF) virus. Virus reproduction in cerebellum neurons. ( 5055807 )
1972
10
The brief survey of the results of studies on Omsk hemorrhagic fever. ( 5301558 )
1967

Variations for Omsk Hemorrhagic Fever

Expression for Omsk Hemorrhagic Fever

Search GEO for disease gene expression data for Omsk Hemorrhagic Fever.

Pathways for Omsk Hemorrhagic Fever

Pathways related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCL4 CCL4L1 CCL5
2
Show member pathways
12.82 CCL4 CCL4L1 CCL5
3
Show member pathways
12.82 CCL4 CCL4L1 CCL5
4
Show member pathways
12.72 CCL4 CCL4L1 CCL5
5
Show member pathways
12.35 CCL4 CCL4L1 CCL5
6
Show member pathways
12.09 CCL4 CCL4L1 CCL5
7
Show member pathways
11.55 CCL4 CCL5
8
Show member pathways
11.52 CCL4 CCL5
9
Show member pathways
11.49 CCL4 CCL4L1
10
Show member pathways
11.46 CCL4 CCL4L1 CCL5
11 11.38 CCL4 CCL4L1
12 11.3 CCL4 CCL4L1
13 11.06 CCL4 CCL5
14 10.65 CCL4 CCL5

GO Terms for Omsk Hemorrhagic Fever

Cellular components related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 CCL4 CCL4L1 CCL5

Biological processes related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.76 CCL4 CCL4L1 CCL5
2 regulation of signaling receptor activity GO:0010469 9.72 CCL4 CCL4L1 CCL5
3 inflammatory response GO:0006954 9.71 CCL4 CCL4L1 CCL5
4 positive regulation of GTPase activity GO:0043547 9.69 CCL4 CCL4L1 CCL5
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CCL4 CCL4L1 CCL5
6 cell-cell signaling GO:0007267 9.61 CCL4 CCL5
7 cellular response to tumor necrosis factor GO:0071356 9.61 CCL4 CCL4L1 CCL5
8 cytokine-mediated signaling pathway GO:0019221 9.6 CCL4 CCL5
9 chemotaxis GO:0006935 9.59 CCL4 CCL5
10 response to virus GO:0009615 9.58 CCL4 CCL5
11 cellular response to interferon-gamma GO:0071346 9.58 CCL4 CCL4L1 CCL5
12 response to toxic substance GO:0009636 9.57 CCL4 CCL5
13 positive regulation of inflammatory response GO:0050729 9.56 CCL4 CCL4L1
14 cellular response to interleukin-1 GO:0071347 9.54 CCL4 CCL4L1 CCL5
15 positive regulation of calcium ion transport GO:0051928 9.52 CCL4 CCL5
16 chemokine-mediated signaling pathway GO:0070098 9.5 CCL4 CCL4L1 CCL5
17 negative regulation by host of viral transcription GO:0043922 9.48 CCL4 CCL5
18 positive regulation of natural killer cell chemotaxis GO:2000503 9.46 CCL4 CCL5
19 neutrophil chemotaxis GO:0030593 9.43 CCL4 CCL4L1 CCL5
20 monocyte chemotaxis GO:0002548 9.33 CCL4 CCL4L1 CCL5
21 lymphocyte chemotaxis GO:0048247 9.13 CCL4 CCL4L1 CCL5
22 eosinophil chemotaxis GO:0048245 8.8 CCL4 CCL4L1 CCL5

Molecular functions related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL4 CCL5
2 CCR5 chemokine receptor binding GO:0031730 9.26 CCL4 CCL5
3 CCR1 chemokine receptor binding GO:0031726 9.16 CCL4 CCL5
4 chemokine activity GO:0008009 9.13 CCL4 CCL4L1 CCL5
5 CCR chemokine receptor binding GO:0048020 8.8 CCL4 CCL4L1 CCL5

Sources for Omsk Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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