OHF
MCID: OMS001
MIFTS: 34

Omsk Hemorrhagic Fever (OHF)

Categories: Blood diseases, Infectious diseases, Nephrological diseases, Rare diseases, Skin diseases

Aliases & Classifications for Omsk Hemorrhagic Fever

MalaCards integrated aliases for Omsk Hemorrhagic Fever:

Name: Omsk Hemorrhagic Fever 12 75 53 59 3 15
Hemorrhagic Fever, Omsk 44 72
Ohf 53 3

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:992
ICD9CM 35 065.1
MeSH 44 D006481
SNOMED-CT 68 48113006
ICD10 33 A98.1
ICD10 via Orphanet 34 A98.1
UMLS via Orphanet 73 C0019103
Orphanet 59 ORPHA319266
UMLS 72 C0019103

Summaries for Omsk Hemorrhagic Fever

NIH Rare Diseases : 53 Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is an infection that occurs primarily in the western Siberia regions of Omsk, Novosibirsk, Kurgan and Tyumen. People can become infected from tick bites, or from contact with the blood, feces, or urine of an infected or dead animal (most commonly a rodent who was infected by a tick). Human exposure may also occur from contaminated water, in a laboratory setting, or through the milk of infected goats or sheep. No person-to-person transmission has been documented. The first signs and symptoms of OHF may begin between 3 to 8 days after exposure and may include chills, fever, nausea, headache, and severe muscle pain. Other symptoms that may occur 3 to 4 days after the first symptoms begin include vomiting, other gastrointestinal problems, and bleeding problems. In rare cases, OHF can cause hearing loss, hair loss, and behavioral or psychological problems. There is no specific treatment for OHF, but important aspects of management include hydration and taking usual precautions for people with bleeding disorders. Some people with OHF recover within 2 weeks with no complications. However, others experience a second episode of symptoms, including fever and encephalitis, about 3 weeks after the initial onset of symptoms. In up to 3% of people with OHF, the infection is fatal.

MalaCards based summary : Omsk Hemorrhagic Fever, also known as hemorrhagic fever, omsk, is related to encephalitis and tick-borne encephalitis, and has symptoms including fever, headache and stiff neck. An important gene associated with Omsk Hemorrhagic Fever is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. Affiliated tissues include cerebellum.

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Omsk hemorrhagic fever virus, which is transmitted by Dermacentor and transmitted by Ixodes species of ticks. The infection has symptom fever, has symptom chills, has symptom headache, has symptom pain in lower and upper extremities, has symptom stiff neck, has symptom papulovesicular rash on the soft palate, has symptom cervical lymphadenopathy, has symptom conjunctival suffusion, has symptom blood in the urine, and has symptom blood in the sputum.

CDC : 3 Omsk hemorrhagic fever (OHF) is caused by Omsk hemorrhagic fever virus (OHFV), a member of the virus family Flaviviridae. OHF was described between 1945 and 1947 in Omsk, Russia from patients with hemorrhagic fever. Rodents serve as the primary host for OHFV, which is transmitted to rodents from the bite of an infected tick. Common tick vectors include Dermacentor reticulatus, Dermacentor marginatus, Ixodes persulcatus and common rodents infected with OHFV include the muskrat (Ondatra zibethica), water vole (Arvicola terrestris), and narrow-skulled voles (Microtus gregalis). Muskrats are not native to the Omsk region but were introduced to the area and are now a common target for hunters and trappers. When infected with the virus, muskrats can become ill and die. OHF occurs in the western Siberia regions of Omsk, Novosibirsk, Kurgan and Tyumen.

Wikipedia : 75 Omsk hemorrhagic fever is a viral hemorrhagic fever caused by a... more...

Related Diseases for Omsk Hemorrhagic Fever

Graphical network of the top 20 diseases related to Omsk Hemorrhagic Fever:



Diseases related to Omsk Hemorrhagic Fever

Symptoms & Phenotypes for Omsk Hemorrhagic Fever

Symptoms:

12
  • fever
  • headache
  • stiff neck
  • chills
  • cervical lymphadenopathy
  • pain in lower
  • papulovesicular rash on the soft palate
  • conjunctival suffusion
  • blood in the urine
  • blood in the sputum

Drugs & Therapeutics for Omsk Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Omsk Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, omsk

Genetic Tests for Omsk Hemorrhagic Fever

Anatomical Context for Omsk Hemorrhagic Fever

MalaCards organs/tissues related to Omsk Hemorrhagic Fever:

41
Cerebellum

Publications for Omsk Hemorrhagic Fever

Articles related to Omsk Hemorrhagic Fever:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study. 38
30949960 2019
2
Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane. 38
30947098 2019
3
Molecular detection of severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses in ixodid ticks collected from vegetation, Republic of Korea, 2014. 38
27211914 2016
4
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. 38
27016316 2016
5
Protective immunity spectrum induced by immunization with a vaccine from the TBEV strain Sofjin. 38
27013433 2016
6
Detection of Langat virus by TaqMan real-time one-step qRT-PCR method. 38
26360297 2015
7
Tick-borne viruses: a review from the perspective of therapeutic approaches. 38
24907187 2014
8
The deduced evolution history of Omsk hemorrhagic fever virus. 38
24259273 2014
9
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses. 38
24663025 2014
10
A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice. 38
24574402 2014
11
Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus. 38
24329534 2014
12
Arboviruses pathogenic for domestic and wild animals. 38
24751197 2014
13
Complete genome sequencing and genetic characterization of Alkhumra hemorrhagic fever virus isolated from Najran, Saudi Arabia. 38
25096447 2014
14
[The Omsk hemorrhagic fever: research results (1946-2013)]. 38
25929029 2014
15
Inhibitors of tick-borne flavivirus reproduction from structure-based virtual screening. 38
24900762 2013
16
Exploring of primate models of tick-borne flaviviruses infection for evaluation of vaccines and drugs efficacy. 38
23585873 2013
17
A tick-borne encephalitis virus vaccine based on the European prototype strain induces broadly reactive cross-neutralizing antibodies in humans. 38
21592984 2011
18
Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5. 38
20817056 2011
19
Comparative analysis of immune responses to Russian spring-summer encephalitis and Omsk hemorrhagic fever viruses in mouse models. 38
20875909 2010
20
Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization. 38
20817489 2010
21
Tick-borne flaviviruses. 38
20513549 2010
22
Zoonotic tick-borne flaviviruses. 38
19765917 2010
23
Clinical evaluation of highly pathogenic tick-borne flavivirus infection in the mouse model. 38
19475605 2009
24
Sub-genomic replicon and virus-like particles of Omsk hemorrhagic fever virus. 38
19277843 2009
25
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. 38
17169393 2007
26
Structure of the envelope protein domain III of Omsk hemorrhagic fever virus. 38
16647096 2006
27
An animal model for the tickborne flavivirus--Omsk hemorrhagic fever virus. 38
15593010 2005
28
Solution structure and structural dynamics of envelope protein domain III of mosquito- and tick-borne flaviviruses. 38
15248774 2004
29
[Tick-borne human pathogenic microorganisms found in Europe and those considered nonpathogenic. Part I: Ticks and Viruses]. 38
15205783 2004
30
Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus. 38
12951023 2003
31
[Specific determination of flaviviruses by molecular hybridization with synthetic deoxyoligonucleotide probes]. 38
12894476 2003
32
Tick-borne flaviviruses. 38
14714436 2003
33
[The Alkhurma virus (family Flaviviridae, genus Flavivirus): an emerging pathogen responsible for hemorrhage fever in the Middle East]. 38
14579470 2003
34
Tick-borne encephalitis. 38
12615309 2003
35
[Effectiveness of virazol, realdiron and interferon inductors in experimental Omsk hemorrhagic fever]. 38
12508680 2002
36
Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia. 38
11554750 2001
37
[Omsk hemorrhagic fever--current status of the problem]. 38
10867986 2000
38
[The clinico-epidemiological characteristics of Omsk hemorrhagic fever in 1988-1992]. 38
9381883 1995
39
Molecular approaches for the treatment of hemorrhagic fever virus infections. 38
8250543 1993
40
[The characteristics of the relationships of arthropods of the refuge complex with the causative agents of transmissible viral infections in bird rookeries]. 38
1923571 1991
41
[Morphological study of Omsk hemorrhagic fever (OHF) virus with the electron microscope]. 38
2561476 1989
42
[Antigenic analysis of tick-borne encephalitis virus group using monoclonal antibodies and immunofluorescence]. 38
2699124 1989
43
[The gray rat (Rattus norvegicus) as a carrier of infectious causative agents in Siberia and the Far East]. 38
2674644 1989
44
Clinical, clinicopathologic, and hematologic features of Kyasanur Forest disease. 38
2665018 1989
45
[Comparative assessment of methods for detecting the Omsk hemorrhagic fever virus]. 38
2678756 1989
46
[Differences in the electrophoretic mobility of the low-molecular virus-specific proteins of viruses of the tick-borne encephalitis complex]. 38
4072163 1985
47
[Experience with using the indirect hemagglutination reaction in studying natural foci of tick-borne encephalitis]. 38
6613088 1983
48
[Experimental study of the possible role of mollusks and aquatic beetles in circulating Omsk hemorrhagic fever virus]. 38
7435015 1980
49
[Long-term epidemiological prognosis relative to Omsk hemorrhagic fever in connection with the anthropogenic transformation of natural foci of this infection]. 38
431497 1979
50
[Mixed infection with tularemia and Omsk hemorrhagic fever in experiments on aquatic field mice]. 38
983583 1976

Variations for Omsk Hemorrhagic Fever

Expression for Omsk Hemorrhagic Fever

Search GEO for disease gene expression data for Omsk Hemorrhagic Fever.

Pathways for Omsk Hemorrhagic Fever

Pathways related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 CCL5 CCL4L1 CCL4
2
Show member pathways
12.89 CCL5 CCL4L1 CCL4
3
Show member pathways
12.87 CCL5 CCL4L1 CCL4
4
Show member pathways
12.79 CCL5 CCL4L1 CCL4
5
Show member pathways
12.54 CCL5 CCL4L1 CCL4
6
Show member pathways
12.45 CCL5 CCL4L1 CCL4
7
Show member pathways
12.25 CCL5 CCL4L1 CCL4
8
Show member pathways
11.87 CCL5 CCL4
9
Show member pathways
11.8 CCL5 CCL4L1 CCL4
10
Show member pathways
11.59 CCL5 CCL4
11
Show member pathways
11.58 CCL4L1 CCL4
12
Show member pathways
11.54 CCL5 CCL4L1 CCL4
13 11.52 CCL4L1 CCL4
14 11.41 CCL4L1 CCL4
15 11.31 CCL5 CCL4
16 11.2 CCL5 CCL4
17 11.06 CCL5 CCL4
18 10.23 CCL5 CCL4L1 CCL4
19 10.03 CCL5 CCL4L1 CCL4

GO Terms for Omsk Hemorrhagic Fever

Cellular components related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 CCL5 CCL4L1 CCL4

Biological processes related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.74 CCL5 CCL4L1 CCL4
2 inflammatory response GO:0006954 9.71 CCL5 CCL4L1 CCL4
3 positive regulation of GTPase activity GO:0043547 9.69 CCL5 CCL4L1 CCL4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CCL5 CCL4L1 CCL4
5 cellular response to tumor necrosis factor GO:0071356 9.61 CCL5 CCL4L1 CCL4
6 cytokine-mediated signaling pathway GO:0019221 9.59 CCL5 CCL4
7 cell-cell signaling GO:0007267 9.58 CCL5 CCL4
8 chemotaxis GO:0006935 9.58 CCL5 CCL4
9 cellular response to interferon-gamma GO:0071346 9.58 CCL5 CCL4L1 CCL4
10 response to virus GO:0009615 9.56 CCL5 CCL4
11 response to toxic substance GO:0009636 9.55 CCL5 CCL4
12 neutrophil chemotaxis GO:0030593 9.54 CCL5 CCL4L1 CCL4
13 positive regulation of calcium ion transport GO:0051928 9.52 CCL5 CCL4
14 cellular response to interleukin-1 GO:0071347 9.5 CCL5 CCL4L1 CCL4
15 negative regulation by host of viral transcription GO:0043922 9.48 CCL5 CCL4
16 positive regulation of natural killer cell chemotaxis GO:2000503 9.46 CCL5 CCL4
17 chemokine-mediated signaling pathway GO:0070098 9.43 CCL5 CCL4L1 CCL4
18 monocyte chemotaxis GO:0002548 9.33 CCL5 CCL4L1 CCL4
19 lymphocyte chemotaxis GO:0048247 9.13 CCL5 CCL4L1 CCL4
20 eosinophil chemotaxis GO:0048245 8.8 CCL5 CCL4L1 CCL4

Molecular functions related to Omsk Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL5 CCL4
2 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 CCL4
3 CCR1 chemokine receptor binding GO:0031726 9.16 CCL5 CCL4
4 chemokine activity GO:0008009 9.13 CCL5 CCL4L1 CCL4
5 CCR chemokine receptor binding GO:0048020 8.8 CCL5 CCL4L1 CCL4

Sources for Omsk Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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