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MCID: ONC002
MIFTS: 52

Onchocerciasis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Onchocerciasis

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MalaCards integrated aliases for Onchocerciasis:

Name: Onchocerciasis 12 76 53 59 55 3 44 15 73
River Blindness 53 3
Infection by Onchocerca Volvulus 12
Onchocerca Volvulus Infection 12
Onchocerciasis, Ocular 73
Robles' Disease 53
Volvulosis 12

Characteristics:

Orphanet epidemiological data:

59
onchocerciasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11678
ICD10 33 B73
ICD9CM 35 125.3
MeSH 44 D009855
NCIt 50 C34861
SNOMED-CT 68 38539003
Orphanet 59 ORPHA2737
ICD10 via Orphanet 34 B73
MESH via Orphanet 45 D009855 D015827
UMLS via Orphanet 74 C0029001 C0029002
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Summaries for Onchocerciasis

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NIH Rare Diseases : 53 Onchocerciasis is a rare tropical parasitic disease transmitted by a black fly. Infection by the parasite can cause eye and skin problems. In humans, the parasitic worms live under the skin (subcutaneous nodules) and produce larvae (microfilariae). The larvae are found throughout the body, but especially in the skin and eyes. Repeated bites by infected flies increase the number of adult worms and larvae. Chronic skin onchocerciasis (onchodermatitis) causes itching, a rash with small pimples (papular rash), scarring, and thickened, leathery skin (lichenification). Other symptoms may develop over time and might include saggy skin (such as ''hanging groin''), patchy areas of much lighter colored skin (leopard skin), ichthyosis-like lesions (''lizard skin''), darkening of the skin, and very severe itching. The eye infection is known as river blindness because the blackfly carrying the parasite lives near fast-flowing waters. Symptoms of an eye infection may include itchy eyes, red eyes, and sensitivity to light (photophobia). In some cases, the larvae may infect the optic nerve. As the common name suggests, infection of the eye by onchocerciasis can lead to vision loss and eventually blindness. The disease is caused by the parasitic worm Onchocerca volvulus and is transmitted by the bite of an infected black fly. About 90% of the cases occur in Africa. Treatment aims to remove the larvae (microfilariae), to improve symptoms, to prevent progression of eye lesions, and to stop the parasite from being passed back to black flies so other people do not become infected. Medications include an anti-parasitic known as ivermectin, antibiotics such as rifampin, azithromycin, and doxycycline, and, another recently approved anti-parasitic drug, Moxidectin.

MalaCards based summary : Onchocerciasis, also known as river blindness, is related to filariasis and skin disease. An important gene associated with Onchocerciasis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ivermectin and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Disease Ontology : 12 A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

CDC : 3  

Wikipedia : 76 Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm... more...

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Related Diseases for Onchocerciasis

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Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 filariasis 31.2 CCL5 IL2 IL5
2 skin disease 29.8 IL13 IL4 IL5
3 tetanus 29.5 IL13 IL2 IL4 IL5
4 schistosomiasis 29.5 IL13 IL2 IL4 IL5 RNASE3
5 trypanosomiasis 29.1 CALR CCL5 IL2 IL4
6 leishmaniasis 29.1 IL13 IL4 IL5 MPI
7 urinary schistosomiasis 28.9 EPX IL13 IL4 IL5 RNASE3
8 dermatitis 27.9 CCL11 IL13 IL4 IL5 RNASE3
9 malaria 27.3 CCL11 CCL5 IL13 IL2 IL4 IL5
10 loiasis 11.3
11 egg allergy 10.7 IL4 IL5
12 virus associated hemophagocytic syndrome 10.7 IL2 IL4
13 loeffler endocarditis 10.7 IL5 RNASE3
14 scleritis 10.7 IL4 IL5
15 trichinosis 10.7 IL4 IL5
16 non-suppurative otitis media 10.7 IL4 IL5
17 jak3-deficient severe combined immunodeficiency 10.7 IL2 IL4
18 cercarial dermatitis 10.7 IL4 IL5
19 cow milk allergy 10.7 IL5 RNASE3
20 toxic oil syndrome 10.6 IL4 IL5
21 primary amebic meningoencephalitis 10.6 IL4 IL5
22 microscopic colitis 10.6 IL2 IL4
23 maxillary sinusitis 10.6 CCL5 RNASE3
24 eosinophilic granuloma 10.6 EPX RNASE3
25 posterior uveitis 10.6 IL2 RBP3
26 vulvovaginal candidiasis 10.6 IL2 IL4
27 eales disease 10.5 IL4 RBP3
28 cellulitis 10.5 IL5 RNASE3
29 conjunctival nevus 10.5 EPX RNASE3
30 sinusitis 10.5 IL5 RNASE3
31 coccidiosis 10.5 IL2 IL4
32 orofacial granulomatosis 10.5 CCL5 IL4
33 cytokine deficiency 10.5 IL13 IL5
34 penicillin allergy 10.5 IL13 IL4
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL13 IL5
36 filarial elephantiasis 10.5
37 cough variant asthma 10.5 IL4 IL5 RNASE3
38 intrinsic asthma 10.5 IL4 IL5 RNASE3
39 necatoriasis 10.5 CALR IL5
40 beta-lactam allergy 10.5 IL13 IL4
41 milk allergy 10.4 IL4 IL5 RNASE3
42 radiculopathy 10.4 CCL5 IL5
43 paracoccidioidomycosis 10.4 IL2 IL4 IL5
44 ascaris lumbricoides infection 10.4 IL13 IL5
45 sezary's disease 10.4 IL2 IL4 IL5
46 epilepsy 10.4
47 african tick-bite fever 10.4 CCL5 IL13
48 genital herpes 10.4 CCL5 IL4
49 wells syndrome 10.3 IL2 IL5 RNASE3
50 severe combined immunodeficiency, x-linked 10.3 IL2 IL4

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to Onchocerciasis
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Symptoms & Phenotypes for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Drugs for Onchocerciasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2 Anticonvulsants Phase 4,Phase 2
3 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
5
Albendazole Approved, Vet_approved Phase 3,Not Applicable 54965-21-8 2082
6 Vitamins Phase 3,Phase 2
7 Anthelmintics Phase 3,Phase 2,Phase 1,Not Applicable
8 Antimitotic Agents Phase 3,Not Applicable
9 Antiprotozoal Agents Phase 3,Phase 2,Not Applicable
10 Milbemycin Phase 3,Phase 2
11
Phenytoin Approved, Vet_approved Phase 2 57-41-0 1775
12
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
13
Azithromycin Approved Phase 2 83905-01-5 55185 447043
14
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
15
Dihydroartemisinin Approved, Investigational Phase 2 71939-50-9 6918483
16
Piperaquine Approved, Investigational Phase 2 4085-31-8 5079497
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
18
Pyridoxal Approved, Nutraceutical Phase 2 66-72-8 1050
19
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
20 Antimanic Agents Phase 2
21 Central Nervous System Depressants Phase 2
22 Diuretics, Potassium Sparing Phase 2
23 GABA Agents Phase 2
24 Micronutrients Phase 2
25 Neurotransmitter Agents Phase 2
26 Psychotropic Drugs Phase 2
27 Sodium Channel Blockers Phase 2
28 Trace Elements Phase 2
29 Tranquilizing Agents Phase 2
30 Vitamin B 6 Phase 2
31 Vitamin B Complex Phase 2
32 Anti-Bacterial Agents Phase 2
33 Antibiotics, Antitubercular Phase 2
34 Antitubercular Agents Phase 2
35 Cytochrome P-450 CYP3A Inducers Phase 2
36 Nucleic Acid Synthesis Inhibitors Phase 2
37 Antimalarials Phase 2
38 Artemisinine Phase 2
39 Artemisinins Phase 2
40 Imatinib Mesylate Phase 2 220127-57-1 123596
41 Protein Kinase Inhibitors Phase 2
42 Folate Nutraceutical Phase 2
43 Vitamin B9 Nutraceutical Phase 2
44
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
45
Diethylcarbamazine Approved, Investigational, Vet_approved ,Not Applicable 90-89-1 3052
46
Mebendazole Approved, Vet_approved 31431-39-7 4030
47
Piperazine Approved, Vet_approved 110-85-0 4837
48
Suramin Approved, Investigational 145-63-1 5361
49
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
50 Lipoxygenase Inhibitors ,Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Recruiting NCT03052998 Phase 4 Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
4 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
5 Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda — 2012 Unknown status NCT01730313 Phase 2 Pyridoxine;Sodium Valproate;Phenytoin;Placebo
6 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
7 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
8 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
9 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
10 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
11 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
12 Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia Completed NCT01905436 Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
13 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Completed NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
14 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Completed NCT01905423 Albendazole and diethylcarbamazine
15 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
16 Prevalence of LF Infection in Districts Not Included in LF Control Activities Recruiting NCT03131401
17 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
18 Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis Active, not recruiting NCT02899936 Not Applicable 3 drug dose - IDA;2 drug dose - DA
19 Lymphatic Filariasis (LF) in Ivory Coast Active, not recruiting NCT02974049 Not Applicable Albendazole;Ivermectin;Diethylcarbamazine
20 Ocular Changes After Ivermectin - (DOLF IVM/Oncho) Not yet recruiting NCT03517462 Not Applicable Ivermectin 3Mg Tab

Search NIH Clinical Center for Onchocerciasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: onchocerciasis

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Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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MalaCards organs/tissues related to Onchocerciasis:

41
Skin, Eye, Testes, Neutrophil, Lymph Node, T Cells, Salivary Gland
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Publications for Onchocerciasis

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Articles related to Onchocerciasis:

(show top 50) (show all 696)
# Title Authors Year
1
Audit of the community-directed treatment with ivermectin (CDTI) for onchocerciasis and factors associated with adherence in three regions of Cameroon. ( 29921312 )
2018
2
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 29348597 )
2018
3
High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20A years of community directed treatment with ivermectin. ( 29921319 )
2018
4
Proof-of-Concept Rapid Diagnostic Test for Onchocerciasis: Exploring Peptide Biomarkers and the Use of Gold Nanoshells as Reporter Nanoparticles. ( 29547260 )
2018
5
Evolution of epilepsy prevalence and incidence in a Tanzanian area endemic for onchocerciasis and the potential impact of community-directed treatment with ivermectin: a cross-sectional study and comparison over 28 years. ( 29605818 )
2018
6
Serious Neurological Adverse Events after Ivermectin-Do They Occur beyond the Indication of Onchocerciasis? ( 29210346 )
2018
7
Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes. ( 29966535 )
2018
8
Geographical distribution and species identification of human filariasis and onchocerciasis in Bioko Island, Equatorial Guinea. ( 29289559 )
2018
9
Elimination of onchocerciasis from Colombia: first proof of concept of river blindness elimination in the world. ( 29642939 )
2018
10
Onchocerciasis prevalence, human migration and risks for onchocerciasis elimination in the Upper Mouhoun, NakambAc and Nazinon river basins in Burkina Faso. ( 29782820 )
2018
11
Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum (s.l.): implications for vector control as a complementary strategy for onchocerciasis elimination in Africa. ( 29843770 )
2018
12
Rethinking the serological threshold for onchocerciasis elimination. ( 29543797 )
2018
13
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. ( 29723238 )
2018
14
Elimination of onchocerciasis in Ecuador: findings of post-treatment surveillance. ( 29690907 )
2018
15
Evaluation of onchocerciasis control in the Upper Denkyira East municipal in the forest area of Ghana: Responses of participants and distributors to the CDTI programme. ( 29932933 )
2018
16
Report of the first international workshop on onchocerciasis-associated epilepsy. ( 29580280 )
2018
17
Sara Lustigman: Developing a vaccine to accelerate onchocerciasis elimination. ( 29174373 )
2018
18
Corrigendum to: 'Onchocerciasis: the beginning of the end'. ( 29659849 )
2018
19
Evaluation of Treatment Coverage and Enhanced Mass Drug Administration for Onchocerciasis and Lymphatic Filariasis in Five Local Government Areas Treating Twice Per Year in Edo State, Nigeria. ( 29943709 )
2018
20
"Cross-border collaboration in onchocerciasis elimination in Uganda: progress, challenges and opportunities from 2008 to 2013". ( 29409509 )
2018
21
Onchocerciasis associated epilepsy: An important neglected public health problem. ( 29325732 )
2018
22
Impact of five annual rounds of mass drug administration with ivermectin on onchocerciasis in Sierra Leone. ( 29628019 )
2018
23
How Can Onchocerciasis Elimination in Africa Be Accelerated? Modeling the Impact of Increased Ivermectin Treatment Frequency and Complementary Vector Control. ( 29860291 )
2018
24
Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis. ( 28381279 )
2017
25
River blindness goes beyond the eye: autoimmune antibodies, cross-reactive with<i>Onchocerca volvulus</i>antigen, detected in brain of patients with Nodding syndrome. ( 29285492 )
2017
26
A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas. ( 29116890 )
2017
27
Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial. ( 28855148 )
2017
28
Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. ( 28056021 )
2017
29
A new methodology for sampling blackflies for the entomological surveillance of onchocerciasis in Brazil. ( 28727733 )
2017
30
Modelling the health and economic impacts of the elimination of river blindness (onchocerciasis) in Africa. ( 28589011 )
2017
31
Rapid integrated clinical survey to determine prevalence and co-distribution patterns of lymphatic filariasis and onchocerciasis in a <i>Loa loa</i> co-endemic area: The Angolan experience. ( 29774284 )
2017
32
Feasibility of utilizing the SD BIOLINE Onchocerciasis IgG4 rapid test in onchocerciasis surveillance in Senegal. ( 28972982 )
2017
33
Unravelling the mysterious onchocerciasis-nodding syndrome link: new developments and future challenges. ( 29299448 )
2017
34
Dermatological manifestations in onchocerciasis: A retrospective study of 400 imported cases. ( 29275076 )
2017
35
Programmatic factors associated with the limited impact of Community-Directed Treatment with Ivermectin to control Onchocerciasis in three drainage basins of South West Cameroon. ( 29155826 )
2017
36
Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). ( 28600214 )
2017
37
Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications. ( 29588943 )
2017
38
Evaluation of Community-Directed Operation of Black Fly Traps for Entomological Surveillance of Onchocerca volvulus Transmission in the Madi-Mid North Focus of Onchocerciasis in Northern Uganda. ( 28820716 )
2017
39
Onchocerciasis in the Democratic Republic of Congo: Survey of knowledge, attitude and perception in Bandundu province. ( 28215917 )
2017
40
Skin snips have no role in programmatic evaluations for onchocerciasis elimination: a reply to Bottomley et al. ( 28335815 )
2017
41
The Genomic Architecture of Novel Simulium damnosum Wolbachia Prophage Sequence Elements and Implications for Onchocerciasis Epidemiology. ( 28611731 )
2017
42
River-specific macrogenomic diversity in Simulium guianense s. l. (Diptera: Simuliidae), a complex of tropical American vectors associated with human onchocerciasis. ( 28727841 )
2017
43
Is imported onchocerciasis a truly rare entity? Case report and review of the literature. ( 28232074 )
2017
44
High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo. ( 28708828 )
2017
45
Progress towards eliminating onchocerciasis in the WHO Region of the Americas: elimination of transmission in the north-east focus of the Bolivarian Republic of Venezuela. ( 29028167 )
2017
46
Evaluation of Community-Directed Operation of Black Fly Traps for Entomological Surveillance of<i>Onchocerca volvulus</i>Transmission in the Madi-Mid North Focus of Onchocerciasis in Northern Uganda. ( 29031285 )
2017
47
Evaluation of Onchocerciasis Transmission in Tanzania: Preliminary Rapid Field Results in the Tukuyu Focus, 2015. ( 28722619 )
2017
48
Application of optimal control to the onchocerciasis transmission model with treatment. ( 29175094 )
2017
49
Adherence to ivermectin is more associated with perceptions of community directed treatment with ivermectin organization than with onchocerciasis beliefs. ( 28806785 )
2017
50
Review of Ethiopian Onchocerciasis Elimination Programme. ( 28878430 )
2017
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Variations for Onchocerciasis

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Expression for Onchocerciasis

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Search GEO for disease gene expression data for Onchocerciasis.
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Pathways for Onchocerciasis

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Pathways related to Onchocerciasis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.83 CALR CCL11 CCL5 EPX IL13 IL2
2
ERK Signaling 64
Show member pathways
 13.67 CCL11 CCL5 CCL7 IL13 IL2 IL4
3
PEDF Induced Signaling 64
Show member pathways
 13.51 CCL11 CCL5 CCL7 IL13 IL2 IL4
4
TGF-Beta Pathway 64
Show member pathways
 13.32 CCL11 CCL5 CCL7 IL13 IL2 IL4
5
Akt Signaling 64
Show member pathways
 13.21 CCL11 CCL5 CCL7 IL13 IL2 IL4
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.19 CCL11 CCL5 IL13 IL2 IL4 IL5
7
PAK Pathway 64
Show member pathways
 13.09 CCL11 CCL5 CCL7 IL13 IL2 IL4
8
CCR5 Pathway in Macrophages 64
Show member pathways
 12.7 CALR CCL11 CCL5 CCL7
9
Pathways in cancer 37
12.66 IL13 IL2 IL4 IL5
10
Influenza A 37
Show member pathways
 12.62 CCL5 IL13 IL2 IL4
11
Allograft rejection 1 37
Show member pathways
 12.5 CALR CCL11 EPX IL13 IL2 IL4
12
Regulation of IFNA signaling 66
Show member pathways
 12.49 IL13 IL2 IL4 IL5
13
Th17 cell differentiation 37
Show member pathways
 12.29 IL13 IL2 IL4 IL5
14
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 12.17 CCL11 CCL5 CCL7
15
Folate Metabolism 1
Show member pathways
 12.16 CCL5 IL2 IL4
16
IL-17 Family Signaling Pathways 65
Show member pathways
 12.13 CCL11 CCL7 IL13 IL4 IL5
17
MAPK Pathway 72
Show member pathways
 11.9 IL13 IL2 IL5
18
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.86 CCL11 CCL5 CCL7
19
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.85 IL2 IL4 IL5
20
Interleukin-4 and 13 signaling 66
11.84 CCL11 IL13 IL4
21
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.81 CCL11 CCL5 CCL7 IL13 IL2 IL4
22
Glucocorticoid receptor regulatory network 1
11.67 IL13 IL2 IL4 IL5
23
Innate Lymphoid Cell Differentiation Pathways 65
11.64 IL13 IL2 IL4 IL5
24
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.63 IL2 IL4 IL5
25
IL4-mediated signaling events 1
11.53 CCL11 IL4 IL5
26
Interleukin-10 signaling 66
11.41 CCL5 IL13 IL4
27
Inflammatory Response Pathway 1
11.2 IL2 IL4 IL5
28
Development and heterogeneity of the ILC family 1
11.18 IL13 IL4 IL5
29
Cytokines and Inflammatory Response 1
11.15 IL13 IL2 IL4 IL5
30
Lung fibrosis 1
11.15 CCL11 CCL5 IL13 IL4 IL5
31
IL12 signaling mediated by STAT4 1
11.08 IL13 IL2
32
OX40 Pathway 64
11.04 IL13 IL2 IL4 IL5
33
Th2 Differentiation Pathway 65
10.68 CCL11 IL13 IL2 IL4 IL5
Sources

GO Terms for Onchocerciasis

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Cellular components related to Onchocerciasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CALR CCL11 CCL5 CCL7 EPX IL13
2 extracellular space GO:0005615 9.36 CALR CCL11 CCL5 CCL7 EPX IL13
3 cell GO:0005623 9.33 CCL11 CCL7 IL2

Biological processes related to Onchocerciasis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.83 CCL11 CCL5 CCL7 IL13 IL5
2 positive regulation of cell migration GO:0030335 9.79 CCL11 CCL5 CCL7
3 chemotaxis GO:0006935 9.78 CCL11 CCL5 CCL7
4 cellular response to tumor necrosis factor GO:0071356 9.77 CCL11 CCL5 CCL7
5 cellular response to interferon-gamma GO:0071346 9.75 CCL11 CCL5 CCL7
6 cellular response to interleukin-1 GO:0071347 9.73 CCL11 CCL5 CCL7
7 chemokine-mediated signaling pathway GO:0070098 9.72 CCL11 CCL5 CCL7
8 neutrophil chemotaxis GO:0030593 9.71 CCL11 CCL5 CCL7
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 CCL5 IL13 IL2
10 positive regulation of T cell proliferation GO:0042102 9.67 CCL5 IL2 IL4
11 monocyte chemotaxis GO:0002548 9.65 CCL11 CCL5 CCL7
12 cytokine-mediated signaling pathway GO:0019221 9.63 CCL11 CCL5 IL13 IL2 IL4 IL5
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.62 IL13 IL4
14 cellular calcium ion homeostasis GO:0006874 9.62 CALR CCL11 CCL5 CCL7
15 positive regulation of JAK-STAT cascade GO:0046427 9.61 CCL5 IL5
16 positive regulation of T cell differentiation GO:0045582 9.6 IL2 IL4
17 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL2 IL5
18 lymphocyte chemotaxis GO:0048247 9.58 CCL11 CCL5 CCL7
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 IL2 IL4
20 positive regulation of B cell proliferation GO:0030890 9.56 IL13 IL2 IL4 IL5
21 eosinophil chemotaxis GO:0048245 9.54 CCL11 CCL5 CCL7
22 positive regulation of natural killer cell chemotaxis GO:2000503 9.51 CCL5 CCL7
23 immune response GO:0006955 9.5 CCL11 CCL5 CCL7 IL13 IL2 IL4
24 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL13 IL4
25 regulation of signaling receptor activity GO:0010469 9.17 CCL11 CCL5 CCL7 IL13 IL2 IL4

Molecular functions related to Onchocerciasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 IL2 IL4 IL5
2 cytokine receptor binding GO:0005126 9.37 IL13 IL4
3 chemokine activity GO:0008009 9.33 CCL11 CCL5 CCL7
4 CCR1 chemokine receptor binding GO:0031726 9.26 CCL5 CCL7
5 cytokine activity GO:0005125 9.17 CCL11 CCL5 CCL7 IL13 IL2 IL4
6 CCR chemokine receptor binding GO:0048020 9.13 CCL11 CCL5 CCL7
Sources

Sources for Onchocerciasis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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