MCID: ONC001
MIFTS: 28

Oncocytic Breast Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Oncocytic Breast Carcinoma

MalaCards integrated aliases for Oncocytic Breast Carcinoma:

Name: Oncocytic Breast Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6585
NCIt 50 C40366
UMLS 73 C1518574

Summaries for Oncocytic Breast Carcinoma

MalaCards based summary : Oncocytic Breast Carcinoma is related to large cell acanthoma and apocrine sweat gland neoplasm, and has symptoms including pain An important gene associated with Oncocytic Breast Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Circadian entrainment and Pathways in cancer. Related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Oncocytic Breast Carcinoma

Diseases related to Oncocytic Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 large cell acanthoma 10.7 KRT14 KRT7
2 apocrine sweat gland neoplasm 10.7 KRT14 KRT7
3 spiradenoma 10.6 KRT14 KRT7
4 brooke-spiegler syndrome 10.6 KRT14 KRT7
5 breast adenomyoepithelioma 10.6 KRT14 KRT7
6 breast myoepithelial neoplasm 10.6 KRT14 KRT7
7 lipoadenoma 10.6 KRT14 KRT7
8 vulvar sarcoma 10.6 AR KRT7
9 meibomian cyst 10.6 AR KRT7
10 epithelial-myoepithelial carcinoma 10.6 KRT14 KRT7
11 endosalpingiosis 10.5 KRT7 PGR
12 female reproductive endometrioid cancer 10.5 KRT7 PGR
13 malignant mixed mullerian tumor 10.5 KRT7 PGR
14 benign metastasizing leiomyoma 10.5 KRT7 PGR
15 pancreatic serous cystadenoma 10.5 KRT7 PGR
16 intraneural perineurioma 10.5 KRT14 KRT7
17 infiltrative basal cell carcinoma 10.5 AR KRT7
18 papillary serous adenocarcinoma 10.5 KRT7 PGR
19 sertoli-leydig cell tumor 10.5 KRT7 PGR
20 mucinous adenofibroma 10.5 ESR1 KRT7
21 large intestine adenocarcinoma 10.5 KRT7 PIP
22 dermoid cyst 10.5 KRT7 PGR
23 cutaneous adenocystic carcinoma 10.5 KRT7 PIP
24 nodular hidradenoma 10.5 KRT7 PIP
25 endocervical carcinoma 10.5 ESR1 KRT7
26 bartholin's duct cyst 10.4 AR PIP
27 white sponge nevus 1 10.4 KRT14 KRT7
28 cystitis cystica 10.4 AR KRT7
29 postmenopausal atrophic vaginitis 10.4 AR ESR1
30 vulvar syringoma 10.4 ESR1 PGR
31 lung leiomyoma 10.4 ESR1 PGR
32 vestibular gland benign neoplasm 10.4 ESR1 PGR
33 bartholin's gland adenoma 10.4 ESR1 PGR
34 vulvar benign neoplasm 10.4 ESR1 PGR
35 trigonitis 10.4 ESR1 PGR
36 vulvar leiomyoma 10.4 ESR1 PGR
37 progesterone resistance 10.4 ESR1 PGR
38 endometrial mucinous adenocarcinoma 10.4 ESR1 PGR
39 bartholin's gland benign neoplasm 10.3 ESR1 PGR
40 deep angioma 10.3 ESR1 PGR
41 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
42 cervical carcinosarcoma 10.3 ESR1 PGR
43 vaginitis 10.3 AR ESR1
44 estrogen excess 10.3 ESR1 PGR
45 intramuscular hemangioma 10.3 ESR1 PGR
46 bronchiolo-alveolar adenocarcinoma 10.3 EGFR KRT7
47 mammographic density 10.3 ESR1 PGR
48 retinitis pigmentosa 47 10.3 ESR1 PGR
49 adenomyosis 10.3 ESR1 PGR
50 retinitis pigmentosa 20 10.3 ESR1 PGR

Graphical network of the top 20 diseases related to Oncocytic Breast Carcinoma:



Diseases related to Oncocytic Breast Carcinoma

Symptoms & Phenotypes for Oncocytic Breast Carcinoma

UMLS symptoms related to Oncocytic Breast Carcinoma:


pain

GenomeRNAi Phenotypes related to Oncocytic Breast Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Oncocytic Breast Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.08 KRT7 ERBB2 PGR AR ESR1 EGFR
2 cardiovascular system MP:0005385 9.97 ERBB2 AR ESR1 EGFR PGR PIP
3 endocrine/exocrine gland MP:0005379 9.95 ERBB2 AR ESR1 EGFR KRT14 PGR
4 digestive/alimentary MP:0005381 9.93 ERBB2 AR ESR1 EGFR KRT14 PIP
5 homeostasis/metabolism MP:0005376 9.91 KRT7 ERBB2 AR ESR1 EGFR KRT14
6 embryo MP:0005380 9.83 ERBB2 AR ESR1 EGFR PGR
7 integument MP:0010771 9.8 ERBB2 AR ESR1 EGFR KRT14 PGR
8 limbs/digits/tail MP:0005371 9.65 ERBB2 AR ESR1 EGFR PGR
9 muscle MP:0005369 9.55 ERBB2 AR ESR1 EGFR PGR
10 neoplasm MP:0002006 9.43 PGR AR ESR1 EGFR KRT14 ERBB2
11 reproductive system MP:0005389 9.17 ERBB2 PGR AR ESR1 EGFR KRT14

Drugs & Therapeutics for Oncocytic Breast Carcinoma

Search Clinical Trials , NIH Clinical Center for Oncocytic Breast Carcinoma

Genetic Tests for Oncocytic Breast Carcinoma

Anatomical Context for Oncocytic Breast Carcinoma

Publications for Oncocytic Breast Carcinoma

Variations for Oncocytic Breast Carcinoma

Expression for Oncocytic Breast Carcinoma

Search GEO for disease gene expression data for Oncocytic Breast Carcinoma.

Pathways for Oncocytic Breast Carcinoma

Pathways related to Oncocytic Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 EGFR ESR1 KRT14 PGR
2 12.43 AR EGFR ERBB2 ESR1
3
Show member pathways
12.22 EGFR ERBB2 ESR1 PGR
4
Show member pathways
11.96 EGFR ERBB2 ESR1
5 11.91 EGFR ERBB2 ESR1
6 11.73 AR EGFR ESR1
7
Show member pathways
11.66 AR EGFR ERBB2
8
Show member pathways
11.3 EGFR ERBB2 ESR1
9 11.23 EGFR ESR1
10
Show member pathways
11.2 AR ESR1
11 11.18 EGFR ERBB2
12
Show member pathways
11.09 AR ESR1 PGR
13 10.99 EGFR ERBB2
14
Show member pathways
10.96 EGFR ERBB2 ESR1 PGR
15 10.95 EGFR ERBB2

GO Terms for Oncocytic Breast Carcinoma

Cellular components related to Oncocytic Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 AR EGFR ERBB2 ESR1 KRT14 KRT7
2 basal plasma membrane GO:0009925 8.96 EGFR ERBB2

Biological processes related to Oncocytic Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.65 AR ESR1 PGR
2 positive regulation of protein kinase B signaling GO:0051897 9.63 EGFR ERBB2 ESR1
3 positive regulation of MAPK cascade GO:0043410 9.58 AR EGFR ERBB2
4 intracellular receptor signaling pathway GO:0030522 9.57 AR ESR1
5 cellular response to epidermal growth factor stimulus GO:0071364 9.56 EGFR ERBB2
6 ERBB2 signaling pathway GO:0038128 9.55 EGFR ERBB2
7 cellular response to estradiol stimulus GO:0071392 9.54 EGFR ESR1
8 positive regulation of phosphorylation GO:0042327 9.52 AR EGFR
9 regulation of cell motility GO:2000145 9.51 EGFR ERBB2
10 regulation of ERK1 and ERK2 cascade GO:0070372 9.49 EGFR ERBB2
11 mammary gland alveolus development GO:0060749 9.43 AR ESR1
12 phosphatidylinositol phosphorylation GO:0046854 9.43 EGFR ERBB2 ESR1
13 negative regulation of ERBB signaling pathway GO:1901185 9.37 EGFR ERBB2
14 steroid hormone mediated signaling pathway GO:0043401 9.33 AR ESR1 PGR
15 positive regulation of transcription by RNA polymerase III GO:0045945 9.32 AR ERBB2
16 morphogenesis of an epithelial fold GO:0060571 8.96 AR EGFR
17 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Oncocytic Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 AR EGFR ESR1 PGR
2 lipid binding GO:0008289 9.67 AR ESR1 PGR
3 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.65 AR ESR1 PGR
4 protein dimerization activity GO:0046983 9.63 AR ERBB2 PIP
5 ATPase binding GO:0051117 9.54 AR ESR1 PGR
6 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.43 EGFR ERBB2
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGFR ERBB2 ESR1
8 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
9 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
10 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
11 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Oncocytic Breast Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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