Aliases & Classifications for Oncocytoma

MalaCards integrated aliases for Oncocytoma:

Name: Oncocytoma 57 12 76 55 40
Oxyphilic Adenoma 12 6 15 73
Follicular Adenoma, Oxyphilic Cell 12
Adenoma, Oxyphilic 44
Hurthle Cell Tumor 73
Oncocytic Neoplasm 73

Characteristics:

OMIM:

57
Inheritance:
mitochondrial


HPO:

32
oncocytoma:
Inheritance mitochondrial inheritance


Classifications:



External Ids:

OMIM 57 553000
Disease Ontology 12 DOID:5389
MeSH 44 D018249
NCIt 50 C3759
SNOMED-CT 68 89439007
MedGen 42 C1510502
SNOMED-CT via HPO 69 108369006 363346000

Summaries for Oncocytoma

OMIM : 57 Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). (553000)

MalaCards based summary : Oncocytoma, also known as oxyphilic adenoma, is related to renal oncocytoma and renal adenoma. An important gene associated with Oncocytoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Technetium Tc 99m Sestamibi and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and thyroid, and related phenotypes are abnormality of metabolism/homeostasis and neoplasm

Wikipedia : 76 An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of... more...

Related Diseases for Oncocytoma

Diseases related to Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 renal oncocytoma 31.8 CAV1 CDH16 CLDN8 FLCN KIT KRT7
2 renal adenoma 30.8 AMACR KRT7
3 papillary adenoma 30.7 KRT7 VIM
4 leiomyoma 30.2 KIT MME VIM
5 collecting duct carcinoma 30.0 AMACR KRT7 MME
6 clear cell renal cell carcinoma 29.8 FLCN KRT7 MME MUC1 VIM
7 hemangioblastoma 29.5 KRT8 MUC1 SYP
8 renal cell carcinoma, papillary, 1 29.2 AMACR CDH16 FLCN KIT KRT7 MME
9 chromophobe renal cell carcinoma 28.4 CDH16 CLDN8 FLCN KIT KRT18 KRT7
10 spindle cell carcinoma 28.3 AMACR CDH16 KRT7 MUC1 SYP VIM
11 renal cell carcinoma, nonpapillary 27.5 AMACR CDH16 CLDN8 FLCN KIT KRT7
12 familial renal oncocytoma 12.1
13 birt-hogg-dube syndrome 11.3
14 thyroid hurthle cell adenoma 10.9
15 jejunal cancer 10.9 KIT KRT7
16 solid adenocarcinoma with mucin production 10.9 KRT7 MUC1
17 adenoid squamous cell carcinoma 10.9 KRT7 VIM
18 mast-cell sarcoma 10.9 KIT VIM
19 endosalpingiosis 10.9 KRT7 MUC1
20 balloon cell malignant melanoma 10.9 KRT7 MME
21 benign metastasizing leiomyoma 10.9 KRT7 VIM
22 cribriform carcinoma 10.9 KIT KRT7
23 reticular perineurioma 10.9 KIT MUC1
24 bile duct mucoepidermoid carcinoma 10.9 KRT7 MUC1
25 cervical adenoma malignum 10.9 KRT7 MME
26 malignant peritoneal mesothelioma 10.9 MUC1 VIM
27 mucinous bronchioloalveolar adenocarcinoma 10.8 KRT7 MUC1
28 adenoid basal cell carcinoma 10.8 KIT KRT7
29 ossifying fibromyxoid tumor 10.8 MUC1 VIM
30 fibrous meningioma 10.8 MUC1 VIM
31 intratubular embryonal carcinoma 10.8 KIT KRT7
32 cervical mucinous adenocarcinoma 10.8 KRT7 MME
33 bile duct cystadenocarcinoma 10.8 KRT7 MUC1
34 syringocystadenoma papilliferum 10.8 MUC1 VIM
35 apocrine adenocarcinoma 10.8 KRT7 MUC1
36 ovary neuroendocrine neoplasm 10.8 KRT7 SYP
37 eccrine porocarcinoma 10.8 MUC1 VIM
38 endometrial mucinous adenocarcinoma 10.8 MUC1 VIM
39 ovarian large-cell neuroendocrine carcinoma 10.8 KRT7 SYP
40 biphasic synovial sarcoma 10.8 MUC1 VIM
41 mucinous adenofibroma 10.8 KRT7 SYP
42 sensory organ benign neoplasm 10.8 KRT7 SYP
43 small cell carcinoma of the bladder 10.8 KRT7 SYP
44 aggressive digital papillary adenocarcinoma 10.8 KIT MUC1
45 myxopapillary ependymoma 10.8 MUC1 VIM
46 primary hepatic neuroendocrine carcinoma 10.8 SYP VIM
47 rhabdoid meningioma 10.7 SYP VIM
48 sarcomatoid renal cell carcinoma 10.7 KIT MUC1
49 bladder lymphoma 10.7 KRT7 MME
50 cutaneous ganglioneuroma 10.7 KIT SYP

Graphical network of the top 20 diseases related to Oncocytoma:



Diseases related to Oncocytoma

Symptoms & Phenotypes for Oncocytoma

Symptoms via clinical synopsis from OMIM:

57
Oncology:
multifocal benign oncocytomas, esp. renal

Lab:
mitochondrial cytchrome c oxidase subunit i gene mutant


Clinical features from OMIM:

553000

Human phenotypes related to Oncocytoma:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 neoplasm 32 HP:0002664

MGI Mouse Phenotypes related to Oncocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 AMACR CAV1 CLDN8 FLCN KIT KRT7
2 liver/biliary system MP:0005370 9.1 AMACR CAV1 KIT KRT18 KRT8 MME

Drugs & Therapeutics for Oncocytoma

Drugs for Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Technetium Tc 99m Sestamibi Not Applicable
2 Radiopharmaceuticals Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Active, not recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride
2 Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples Completed NCT00001814
3 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Recruiting NCT02160925 Not Applicable
4 Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer Terminated NCT00491621 Not Applicable

Search NIH Clinical Center for Oncocytoma

Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oncocytoma

Anatomical Context for Oncocytoma

MalaCards organs/tissues related to Oncocytoma:

41
Kidney, Pituitary, Thyroid, Liver, Lung, Prostate, Salivary Gland

Publications for Oncocytoma

Articles related to Oncocytoma:

(show top 50) (show all 525)
# Title Authors Year
1
Parotid Oncocytoma as a Manifestation of Birt-Hogg-DubAc Syndrome. ( 29971177 )
2018
2
Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. ( 29353061 )
2018
3
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? ( 29970253 )
2018
4
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. ( 29915083 )
2018
5
Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis. ( 29132724 )
2018
6
Oncocytoma of the adrenal gland in Birt-Hogg-Dube syndrome. ( 29930184 )
2018
7
Periocular cutaneous oncocytoma. ( 28940297 )
2018
8
Oncocytoma managed by active surveillance in a transplant allograft kidney: a case report. ( 29966524 )
2018
9
Functional plurihormonal adrenal oncocytoma: case report and literature review. ( 29375834 )
2018
10
A back-to-back tumor composed of papillary renal cell carcinoma and oncocytoma treated by laparoscopic partial nephrectomy: a case report. ( 29779490 )
2018
11
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29738030 )
2018
12
Nasal oncocytoma causing unilateral epiphora in an elderly patient: the vital role of nasendoscopy. ( 29523610 )
2018
13
Contemporary Surgical Management of Renal Oncocytoma: A nation's outcome. ( 29397002 )
2018
14
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. ( 29752278 )
2018
15
Differentiating papillary type I RCC from clear cell RCC and oncocytoma: application of whole-lesion volumetric ADC measurement. ( 29520425 )
2018
16
Extrarenal retroperitoneal angiomyolipoma with oncocytoma. ( 29343920 )
2018
17
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29796579 )
2018
18
Re: Surgical Histopathology for Suspected Oncocytoma on Renal Mass Biopsy: A Systematic Review and Meta-Analysis. ( 29310179 )
2018
19
Re: The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. ( 29370653 )
2017
20
Liver Metastases From Renal Oncocytoma With Vascular Extension. ( 28682831 )
2017
21
Renal Angiomyolipoma With Incidental Oncocytoma: A Case Report and Review of Literature. ( 29088523 )
2017
22
Parotid metastasis of renal cell carcinoma, mimicking primary clear cell oncocytoma: report of a case and brief review of the literature. ( 29449729 )
2017
23
Exploring Multiphoton Microscopy as a Novel Tool to Differentiate Chromophobe Renal Cell Carcinoma From Oncocytoma in Fixed Tissue Sections. ( 29219617 )
2017
24
Value of triphasic MDCT in the differentiation of small renal cell carcinoma and oncocytoma. ( 28862728 )
2017
25
Surgical removal of a choroid plexus oncocytoma in an adult cat. ( 28379624 )
2017
26
Modern Pathologic Diagnosis of Renal Oncocytoma. ( 29090117 )
2017
27
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione. ( 29285300 )
2017
28
Concurrent Oncocytoma and Two Angiomyolipomas in a Diabetic Kidney: A Very Rare Condition. ( 28918618 )
2017
29
Giant renal oncocytoma with classic stellate scar. ( 28130290 )
2017
30
Adrenal Oncocytoma - A Rare Functional Tumor Presenting as Cushing Syndrome. ( 29327532 )
2017
31
Remote Development of Tumor-to-Tumor Metastasis of Breast Adenocarcinoma in a Renal Oncocytoma. ( 28551171 )
2017
32
Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. ( 28943925 )
2017
33
Caruncular Oncocytoma Mimicking Malignant Melanoma. ( 29344489 )
2017
34
Quantitative computer-aided diagnostic algorithm for automated detection of peak lesion attenuation in differentiating clear cell from papillary and chromophobe renal cell carcinoma, oncocytoma, and fat-poor angiomyolipoma on multiphasic multidetector computed tomography. ( 28280876 )
2017
35
Renal oncocytoma in a cat with chronic renal failure. ( 28491452 )
2017
36
Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity. ( 28843710 )
2017
37
Adrenocortical oncocytoma: 11 Case reports and review of the literature. ( 29310349 )
2017
38
Oncocytoma: A Differential Consideration for an Incidentally Detected FDG-Avid Renal Mass on PET/CT. ( 29299091 )
2017
39
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-I^-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma. ( 28668830 )
2017
40
A systematic review and meta-analysis of immunohistochemical biomarkers that differentiate chromophobe renal cell carcinoma from renal oncocytoma. ( 26951082 )
2016
41
Adrenal Collision Tumor: Coexistence of Pigmented Adrenal Cortical Oncocytoma and Ganglioneuroma. ( 28053800 )
2016
42
Renal Oncocytoma With Perinephric Fat Invasion. ( 27170678 )
2016
43
Renal oncocytoma, small cell variant, with pseudorosettes, showing cyclin D1 expression and tubulovesicular cristae of mitochondria. ( 27076064 )
2016
44
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ( 26670126 )
2016
45
Active surveillance is suitable for intermediate term follow-up of renal oncocytoma diagnosed by percutaneous core biopsy. ( 27457972 )
2016
46
Rare Case of Hybrid Oncocytoma and Chromophobe Renal Cell Carcinoma in a Pediatric Patient. ( 26718018 )
2016
47
Spindle cell oncocytoma of adenohypophysis: Report of a case and immunohistochemical review of literature. ( 26839157 )
2016
48
Bladder leiomyoma in male patient presenting with renal oncocytoma: Are the two conditions related? ( 27453673 )
2016
49
Renal Oncocytoma with Vascular Invasion: A Series of 22 Cases. ( 27498062 )
2016
50
Renal oncocytoma: A report of two cases and review of the literature. ( 27347140 )
2016

Variations for Oncocytoma

ClinVar genetic disease variations for Oncocytoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh37 Chromosome MT, 14248: 14248
2 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh38 Chromosome MT, 14248: 14248

Cosmic variations for Oncocytoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM25680 VHL kidney,NS,carcinoma,oncocytic c.563T>G p.L188R 3:10149886-10149886 4
2 COSM28413 VAV1 kidney,NS,carcinoma,granular c.1876G>A p.E626K 19:6836530-6836530 4
3 COSM26012 UBR4 kidney,NS,carcinoma,oncocytic c.4564G>A p.A1522T 1:19164389-19164389 4
4 COSM25647 SMC6 kidney,NS,carcinoma,oncocytic c.2911-1G>C p.? 2:17670576-17670576 4
5 COSM130403 SF3B1 kidney,NS,carcinoma,oncocytic c.3122G>A p.R1041H 2:197398473-197398473 4
6 COSM28419 MDH1 kidney,NS,carcinoma,oncocytic c.894G>C p.K298N 2:63606876-63606876 4
7 COSM27600 FOXA2 kidney,NS,carcinoma,oncocytic c.72C>T p.G24G 20:22583152-22583152 4
8 COSM26015 ALDH7A1 kidney,NS,carcinoma,oncocytic c.1486A>G p.I496V 5:126545015-126545015 4

Expression for Oncocytoma

Search GEO for disease gene expression data for Oncocytoma.

Pathways for Oncocytoma

Pathways related to Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 CAV1 KRT18 KRT7 KRT8 MUC1 VIM
2
Show member pathways
11.29 KRT18 KRT7 KRT8 VIM
3 11.2 KRT8 MME VIM
4 10.51 CDH16 VIM

GO Terms for Oncocytoma

Cellular components related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 CDH16 KRT18 KRT7 KRT8 MME MUC1
2 apicolateral plasma membrane GO:0016327 9.26 CLDN8 KRT8
3 neuron projection terminus GO:0044306 9.16 MME SYP
4 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
5 intermediate filament GO:0005882 8.92 KRT18 KRT7 KRT8 VIM

Biological processes related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.33 KRT18 KRT7 KRT8
2 viral process GO:0016032 9.1 CAV1 KRT18 KRT7 KRT8 SLC25A5 VIM
3 hepatocyte apoptotic process GO:0097284 8.96 KRT18 KRT8

Molecular functions related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.13 KRT18 KRT8 VIM
2 structural molecule activity GO:0005198 9.1 CAV1 CLDN8 KRT18 KRT7 KRT8 VIM

Sources for Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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