Aliases & Classifications for Oncocytoma

MalaCards integrated aliases for Oncocytoma:

Name: Oncocytoma 58 12 77 56 41
Oxyphilic Adenoma 12 6 15 17 74
Follicular Adenoma, Oxyphilic Cell 12
Adenoma, Oxyphilic 45
Hurthle Cell Tumor 74
Oncocytic Neoplasm 74

Characteristics:

OMIM:

58
Inheritance:
mitochondrial


HPO:

33
oncocytoma:
Inheritance mitochondrial inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:5389
OMIM 58 553000
MeSH 45 D018249
NCIt 51 C3759
SNOMED-CT 69 89439007
MedGen 43 C1510502
SNOMED-CT via HPO 70 108369006 363346000

Summaries for Oncocytoma

OMIM : 58 Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). (553000)

MalaCards based summary : Oncocytoma, also known as oxyphilic adenoma, is related to renal oncocytoma and renal adenoma. An important gene associated with Oncocytoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Technetium Tc 99m Sestamibi and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include kidney, salivary gland and pituitary, and related phenotypes are abnormality of metabolism/homeostasis and neoplasm

Wikipedia : 77 An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of... more...

Related Diseases for Oncocytoma

Diseases related to Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 renal oncocytoma 33.1 CAV1 CDH16 CLDN8 FLCN KIT KRT7
2 renal adenoma 30.5 AMACR KRT7
3 renal cell carcinoma, papillary, 1 30.2 AMACR CDH16 KIT KRT7 MME
4 papillary tumor of the pineal region 30.0 MUC1 SYP VIM
5 leiomyoma 30.0 KIT MME VIM
6 cystadenoma 30.0 KRT7 MME MUC1 SYP
7 collecting duct carcinoma 29.9 AMACR KRT7 MME
8 chromophobe renal cell carcinoma 29.8 CDH16 CLDN8 FLCN KIT KRT18 KRT7
9 pineal gland cancer 29.7 KRT18 SYP
10 hemangioblastoma 29.6 KRT8 MUC1 SYP
11 renal cell carcinoma, nonpapillary 29.5 AMACR CDH16 CLDN8 FLCN KIT KRT7
12 clear cell renal cell carcinoma 29.3 CAV1 CDH16 FLCN KRT7 MME MUC1
13 spindle cell carcinoma 29.1 AMACR CDH16 KRT7 MUC1 SYP VIM
14 familial renal oncocytoma 12.3
15 birt-hogg-dube syndrome 11.4
16 thyroid hurthle cell adenoma 11.1
17 adenoma 10.5
18 adenomatoid tumor 10.5 KRT7 VIM
19 paget disease, extramammary 10.5 KRT7 MUC1
20 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT7 MUC1
21 senile angioma 10.5 KIT VIM
22 amelanotic melanoma 10.5 KIT VIM
23 ampulla of vater adenocarcinoma 10.5 KRT7 MUC1
24 biliary papillomatosis 10.5 KRT7 MUC1
25 reticulum cell sarcoma 10.5 MUC1 VIM
26 well-differentiated liposarcoma 10.5 KRT7 MUC1
27 syringoma 10.5 MUC1 VIM
28 mesenchymal chondrosarcoma 10.5 MUC1 VIM
29 breast adenomyoepithelioma 10.5 KRT7 MME
30 breast myoepithelial neoplasm 10.4 KRT7 MME
31 sarcomatoid renal cell carcinoma 10.4 KIT MUC1
32 rete testis adenocarcinoma 10.4 KIT MME
33 adenosarcoma 10.4 KIT MME
34 papillary hidradenoma 10.4 KIT MME
35 rete testis neoplasm 10.4 KIT MME
36 chronic orbital inflammation 10.4 MME MUC1
37 glycogen-rich clear cell breast carcinoma 10.4 KRT7 SYP
38 gastric squamous cell carcinoma 10.4 KRT7 SYP
39 pulmonary sclerosing hemangioma 10.4 KRT7 SYP
40 melanotic neuroectodermal tumor 10.4 SYP VIM
41 ceruminoma 10.4 KIT KRT7
42 jejunal cancer 10.4 KIT KRT7
43 angiocentric glioma 10.4 SYP VIM
44 angiomyoma 10.4 KIT SYP
45 mediastinal cancer 10.4 KIT SYP
46 mast-cell sarcoma 10.4 KIT VIM
47 solid adenocarcinoma with mucin production 10.4 KRT7 MUC1
48 balloon cell malignant melanoma 10.4 KRT7 MME
49 reticular perineurioma 10.4 KIT MUC1
50 pancreatoblastoma 10.4 MUC1 SYP

Graphical network of the top 20 diseases related to Oncocytoma:



Diseases related to Oncocytoma

Symptoms & Phenotypes for Oncocytoma

Human phenotypes related to Oncocytoma:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 33 HP:0001939
2 neoplasm 33 HP:0002664

Symptoms via clinical synopsis from OMIM:

58
Oncology:
multifocal benign oncocytomas, esp. renal

Lab:
mitochondrial cytchrome c oxidase subunit i gene mutant

Clinical features from OMIM:

553000

GenomeRNAi Phenotypes related to Oncocytoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.4 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

MGI Mouse Phenotypes related to Oncocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 AMACR CAV1 CLDN8 FLCN KIT KRT7
2 liver/biliary system MP:0005370 9.1 AMACR CAV1 KIT KRT18 KRT8 MME

Drugs & Therapeutics for Oncocytoma

Drugs for Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Technetium Tc 99m Sestamibi Not Applicable
2 Radiopharmaceuticals Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Active, not recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride
2 Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples Completed NCT00001814
3 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Active, not recruiting NCT02160925 Not Applicable
4 Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer Terminated NCT00491621 Not Applicable

Search NIH Clinical Center for Oncocytoma

Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oncocytoma

Anatomical Context for Oncocytoma

MalaCards organs/tissues related to Oncocytoma:

42
Kidney, Salivary Gland, Pituitary, Thyroid, Lung, Breast, Prostate

Publications for Oncocytoma

Articles related to Oncocytoma:

(show top 50) (show all 852)
# Title Authors Year
1
Incidental retroperitoneal oncocytoma (Ectopic oncocytic adrenocortical adenoma): Case report and review of the literature. ( 30706878 )
2019
2
Discrimination of oncocytoma and chromophobe renal cell carcinoma using MRI. ( 30644365 )
2019
3
Chromophobe renal cell carcinoma or oncocytoma: a manner of challenge in frozen section diagnosis. ( 30794153 )
2019
4
Deep learning and radiomics: the utility of Google TensorFlow™ Inception in classifying clear cell renal cell carcinoma and oncocytoma on multiphasic CT. ( 30778739 )
2019
5
The "central stellate scar" sign in renal oncocytoma. ( 30697659 )
2019
6
A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma. ( 30728892 )
2019
7
Cystic renal oncocytoma mimicking renal cell carcinoma. ( 30787581 )
2019
8
Renal Oncocytoma and Retroperitoneal Ancient Schwannoma: A Benign Mimic of Metastatic Renal Cell Carcinoma. ( 30915254 )
2019
9
Parotid Oncocytoma as a Manifestation of Birt-Hogg-DubAc Syndrome. ( 29971177 )
2018
10
Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. ( 29353061 )
2018
11
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? ( 29970253 )
2018
12
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. ( 29915083 )
2018
13
Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis. ( 29132724 )
2018
14
Oncocytoma of the adrenal gland in Birt-Hogg-Dube syndrome. ( 29930184 )
2018
15
Periocular cutaneous oncocytoma. ( 28940297 )
2018
16
Oncocytoma managed by active surveillance in a transplant allograft kidney: a case report. ( 29966524 )
2018
17
Functional plurihormonal adrenal oncocytoma: case report and literature review. ( 29375834 )
2018
18
A back-to-back tumor composed of papillary renal cell carcinoma and oncocytoma treated by laparoscopic partial nephrectomy: a case report. ( 29779490 )
2018
19
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29738030 )
2018
20
Nasal oncocytoma causing unilateral epiphora in an elderly patient: the vital role of nasendoscopy. ( 29523610 )
2018
21
Contemporary Surgical Management of Renal Oncocytoma: A nation's outcome. ( 29397002 )
2018
22
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. ( 29752278 )
2018
23
Differentiating papillary type I RCC from clear cell RCC and oncocytoma: application of whole-lesion volumetric ADC measurement. ( 29520425 )
2018
24
Extrarenal retroperitoneal angiomyolipoma with oncocytoma. ( 29343920 )
2018
25
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29796579 )
2018
26
Re: Surgical Histopathology for Suspected Oncocytoma on Renal Mass Biopsy: A Systematic Review and Meta-Analysis. ( 29310179 )
2018
27
Autoimmune retinopathy and optic neuropathy associated with enolase-positive renal oncocytoma. ( 30229140 )
2018
28
Caspase 3 as a Novel Marker to Distinguish Chromophobe Renal Cell Carcinoma from Oncocytoma. ( 30467700 )
2018
29
MicroRNAs as Urinary Biomarker for Oncocytoma. ( 30116406 )
2018
30
Is spindle cell oncocytoma a true entity or a variant of pituicytoma? A case report with review of literature. ( 30233016 )
2018
31
Caruncular Oncocytoma: Report of Two Cases with Review of Literature. ( 30258801 )
2018
32
18F-DCFPyL PET/CT in Oncocytoma. ( 30300203 )
2018
33
Adrenal Oncocytoma: An Incidental Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings with Magnetic Resonance Imaging Correlation. ( 30386060 )
2018
34
A rare combination of giant right retroperitoneal schwannoma and right adrenal oncocytoma as an incidental finding. ( 30397503 )
2018
35
Spindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA). ( 30431381 )
2018
36
A Case of Renal Oncocytoma with Renal Venous Tumor Thrombus. ( 30473547 )
2018
37
Spindle cell oncocytoma of the pituitary gland. ( 30485213 )
2018
38
Ureteral obstruction by sloughed tumor complicating cryoablation of a renal oncocytoma. ( 30533167 )
2018
39
Oncocytoma Parotid Gland. ( 30693257 )
2018
40
Oncocytoma of the Parotid Gland with Facial Nerve Paralysis. ( 30034902 )
2018
41
Papillary renal cell carcinoma with cytologic and molecular genetic features overlapping with renal oncocytoma: Analysis of 10 cases. ( 30072012 )
2018
42
Re: The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. ( 29370653 )
2017
43
Liver Metastases From Renal Oncocytoma With Vascular Extension. ( 28682831 )
2017
44
Renal Angiomyolipoma With Incidental Oncocytoma: A Case Report and Review of Literature. ( 29088523 )
2017
45
Parotid metastasis of renal cell carcinoma, mimicking primary clear cell oncocytoma: report of a case and brief review of the literature. ( 29449729 )
2017
46
Exploring Multiphoton Microscopy as a Novel Tool to Differentiate Chromophobe Renal Cell Carcinoma From Oncocytoma in Fixed Tissue Sections. ( 29219617 )
2017
47
Value of triphasic MDCT in the differentiation of small renal cell carcinoma and oncocytoma. ( 28862728 )
2017
48
Surgical removal of a choroid plexus oncocytoma in an adult cat. ( 28379624 )
2017
49
Modern Pathologic Diagnosis of Renal Oncocytoma. ( 29090117 )
2017
50
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione. ( 29285300 )
2017

Variations for Oncocytoma

ClinVar genetic disease variations for Oncocytoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh37 Chromosome MT, 14248: 14248
2 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh38 Chromosome MT, 14248: 14248

Cosmic variations for Oncocytoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM25680 VHL kidney,NS,carcinoma,oncocytic c.563T>G p.L188R 3:10149886-10149886 0
2 COSM28413 VAV1 kidney,NS,carcinoma,granular c.1876G>A p.E626K 19:6836530-6836530 0
3 COSM26012 UBR4 kidney,NS,carcinoma,oncocytic c.4564G>A p.A1522T 1:19164389-19164389 0
4 COSM25647 SMC6 kidney,NS,carcinoma,oncocytic c.2911-1G>C p.? 2:17670576-17670576 0
5 COSM130403 SF3B1 kidney,NS,carcinoma,oncocytic c.3122G>A p.R1041H 2:197398473-197398473 0
6 COSM28419 MDH1 kidney,NS,carcinoma,oncocytic c.894G>C p.K298N 2:63606876-63606876 0
7 COSM27600 FOXA2 kidney,NS,carcinoma,oncocytic c.72C>T p.G24G 20:22583152-22583152 0
8 COSM26015 ALDH7A1 kidney,NS,carcinoma,oncocytic c.1486A>G p.I496V 5:126545015-126545015 0

Expression for Oncocytoma

Search GEO for disease gene expression data for Oncocytoma.

Pathways for Oncocytoma

Pathways related to Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 CAV1 KRT18 KRT7 KRT8 MUC1 VIM
2
Show member pathways
11.29 KRT18 KRT7 KRT8 VIM
3 11.2 KRT8 MME VIM
4 10.51 CDH16 VIM

GO Terms for Oncocytoma

Cellular components related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 CDH16 KRT18 KRT7 KRT8 MME MUC1
2 integral component of plasma membrane GO:0005887 9.73 CAV1 CDH16 KIT MME MUC1 SLC25A5
3 neuron projection terminus GO:0044306 9.32 MME SYP
4 apicolateral plasma membrane GO:0016327 9.16 CLDN8 KRT8
5 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
6 intermediate filament GO:0005882 8.92 KRT18 KRT7 KRT8 VIM

Biological processes related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.33 KRT18 KRT7 KRT8
2 viral process GO:0016032 9.1 CAV1 KRT18 KRT7 KRT8 SLC25A5 VIM
3 hepatocyte apoptotic process GO:0097284 8.96 KRT18 KRT8

Molecular functions related to Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.13 KRT18 KRT8 VIM
2 structural molecule activity GO:0005198 9.1 CAV1 CLDN8 KRT18 KRT7 KRT8 VIM

Sources for Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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