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MCID: OPN001
MIFTS: 53

Open-Angle Glaucoma

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Open-Angle Glaucoma

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MalaCards integrated aliases for Open-Angle Glaucoma:

Name: Open-Angle Glaucoma 12 15 17
Glaucoma, Open-Angle 45 74
Open Angle Glaucoma 12
Pigmentary Glaucoma 12
Wide-Angle Glaucoma 12
Glaucoma Open-Angle 56
Glaucoma Simplex 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1067
MeSH 45 D005902
NCIt 51 C34641
SNOMED-CT 69 46168003 84494001
UMLS 74 C0017612
Sources

Summaries for Open-Angle Glaucoma

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Disease Ontology : 12 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

MalaCards based summary : Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to glaucoma 1, open angle, a and glaucoma, primary open angle. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. The drugs Latanoprost and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are homeostasis/metabolism and vision/eye

Sources

Related Diseases for Open-Angle Glaucoma

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Diseases in the Open-Angle Glaucoma family:

Glaucoma 1, Open Angle, a Glaucoma, Primary Open Angle
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 glaucoma 1, open angle, a 34.4 CYP1B1 MYOC OPTN
2 glaucoma, primary open angle 32.7 ASB10 CAV2 CYP1B1 ELN GSTM1 LOXL1
3 exfoliation syndrome 32.4 ELN LOXL1 MMP1
4 ocular hypertension 32.4 MYOC OPTN TMCO1
5 low tension glaucoma 31.9 MYOC OPTN TBK1 WDR36
6 juvenile glaucoma 31.8 CYP1B1 ELN MYOC NTF4 OPTN TGFB2
7 primary angle-closure glaucoma 31.7 CYP1B1 MYOC OPTN
8 optic nerve disease 31.3 MYOC OPA1 OPTN
9 glaucoma 3, primary infantile, b 31.2 CYP1B1 LTBP2
10 glaucoma 3, primary congenital, a 31.1 CYP1B1 LTBP2 MYOC OPTN
11 glaucoma, normal tension 31.1 LOXL1 OPA1 OPTN
12 primary congenital glaucoma 30.9 CYP1B1 LTBP2 MYOC OPTN WDR36
13 chronic closed-angle glaucoma 30.7 OPTN TGFB2
14 glaucoma-related pigment dispersion syndrome 30.6 CYP1B1 LOXL1
15 megalocornea 30.4 LTBP2 OPTN
16 neovascular glaucoma 30.4 OPTN TGFB2
17 residual stage of open angle glaucoma 12.6
18 glaucoma 1, open angle, f 12.4
19 glaucoma 1, open angle, g 12.2
20 glaucoma 1, open angle, o 12.2
21 glaucoma 1, open angle, p 12.2
22 intraocular pressure quantitative trait locus 11.9
23 glaucoma 1, primary open angle, c 11.7
24 cataract 10.9
25 myopia 10.7
26 neuropathy 10.7
27 diabetes mellitus 10.6
28 hypertension, essential 10.5
29 helicobacter pylori infection 10.5
30 yemenite deaf-blind hypopigmentation syndrome 10.5
31 ischemic optic neuropathy 10.5
32 hypothyroidism 10.5
33 macular degeneration, age-related, 1 10.5
34 alzheimer disease 10.4
35 acrofrontofacionasal dysostosis 10.4 CYP1B1 OPTN
36 nonarteritic anterior ischemic optic neuropathy 10.4
37 retinal vein occlusion 10.4
38 hydrophthalmos 10.4 CYP1B1 LTBP2 OPTN
39 dementia 10.4
40 axenfeld-rieger syndrome, type 2 10.3 ASB10 OPTN
41 axenfeld-rieger syndrome 10.3 ASB10 CYP1B1 OPTN
42 aging 10.3
43 early-onset glaucoma 10.3 CYP1B1 MYOC
44 excessive tearing 10.3 CYP1B1 LTBP2 MYOC OPTN
45 sleep apnea 10.2
46 central retinal vein occlusion 10.2
47 macular retinal edema 10.2
48 senile cataract 10.2
49 refractive error 10.2
50 migraine with or without aura 1 10.2

Comorbidity relations with Open-Angle Glaucoma via Phenotypic Disease Network (PDN):


Anatomical Narrow Angle Borderline Glaucoma Glaucoma, Primary Open Angle
Hypertension, Essential Ocular Hypotension

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to Open-Angle Glaucoma
Sources

Symptoms & Phenotypes for Open-Angle Glaucoma

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MGI Mouse Phenotypes related to Open-Angle Glaucoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 CAV2 CYP1B1 LMX1B LOXL1 MMP1 NTF4
2 vision/eye MP:0005391 9.23 CYP1B1 LMX1B LTBP2 MYOC OPA1 OPTC
Sources

Drugs & Therapeutics for Open-Angle Glaucoma

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Drugs for Open-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130209-82-4 5311221 5282380
2
Travoprost Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 157283-68-6 5282226
3
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 155206-00-1 5311027
4
Dorzolamide Approved Phase 4,Phase 3,Phase 2,Not Applicable 120279-96-1 5284549 3154
5
Timolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 26839-75-8 5478 33624
6
Ketorolac Approved Phase 4,Not Applicable 74103-06-3, 66635-83-4 3826
7
Brinzolamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 138890-62-7 68844
8
Fluorouracil Approved Phase 4,Phase 2,Not Applicable 51-21-8 3385
9
Apraclonidine Approved Phase 4,Not Applicable 66711-21-5 2216
10
Sorbitol Approved Phase 4 50-70-4 5780
11
Pilocarpine Approved, Investigational Phase 4,Not Applicable 54-71-7, 92-13-7 5910
12
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
13
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
14
Bevacizumab Approved, Investigational Phase 4,Not Applicable 216974-75-3
15
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
17
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
19
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
20
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
21
Maleic acid Experimental, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 110-17-8, 110-16-7 444972
22 Cloprostenol Vet_approved Phase 4,Phase 3 54276-21-0
23 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Carbonic Anhydrase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Ketorolac Tromethamine Phase 4,Not Applicable
33 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 70359-46-5
34 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Mitomycins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Lubricant Eye Drops Phase 4,Phase 3,Phase 2,Not Applicable
47 Anti-Infective Agents, Local Phase 4,Phase 2
48 Benzalkonium Compounds Phase 4,Phase 2
49 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
50 Luteolytic Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 755)
# Name Status NCT ID Phase Drugs
1 A Study of the Glaukos Trabecular Micro-bypass Stent in Open Angle Glaucoma Subjects 1 Stent Versus 2 Unknown status NCT00326079 Phase 4
2 Glaucoma Treatment Using Focused Ultrasound in Open Angle Glaucoma Patients Unknown status NCT02789293 Phase 4
3 The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma Unknown status NCT02388360 Phase 4 topical prostaglandin analogs
4 Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma Unknown status NCT01580254 Phase 4 IOPIZE© Latanoprost eyedrops;GALAXIA© Latanoprost eyedrops;Latanoprost RATIOPHARM© latanoprost eyedrops
5 PASCAL Trabeculoplasty Unknown status NCT00804323 Phase 4
6 Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension Unknown status NCT02796560 Phase 4 Brand name travoprost;Generic travoprost
7 Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose Unknown status NCT02017327 Phase 4 Monoprost;Lumigan 0.01%;Lumigan 0.03% Unit Dose
8 Prospective, Randomized, Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG Unknown status NCT02231515 Phase 4
9 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
10 The Laser in Pseudoexfoliation (LIP) Study Unknown status NCT01704989 Phase 4 Prostagladin
11 Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves Unknown status NCT01883856 Phase 4
12 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
13 Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma Completed NCT01956942 Phase 4
14 Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants Completed NCT02006693 Phase 4
15 Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost Completed NCT01443988 Phase 4 Travoprost
16 An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More Completed NCT01979913 Phase 4 Saflutan® 15 microgram/ml Augentropfen im Einzeldosisbehältnis
17 Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents Completed NCT01252888 Phase 4
18 A Study of the Glaukos Trabecular Micro-Bypass Stent in Refractory Open Angle Glaucoma Subjects Completed NCT00326040 Phase 4
19 A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00326014 Phase 4
20 Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents Completed NCT01252862 Phase 4
21 24-hour Intraocular Pressure (IOP) Control With Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combination in Open-angle Glaucoma Completed NCT00397241 Phase 4 Drug: dorzolamide/timolol;Drug: latanoprost/timolol;dorzolamide/timolol and latanoprost;placebo (artificial tears)
22 Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®) Completed NCT01464424 Phase 4 Travoprost 0.004% ophthalmic solution;Bimatoprost 0.01% ophthalmic solution
23 Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED) Completed NCT00545064 Phase 4 dorzolamide hydrochloride (+) timolol maleate
24 Efficacy and Tolerability of an Innovative Formulation of BAK-free Latanoprost Completed NCT03331770 Phase 4 Latanoprost Ophthalmic Product
25 Phase IV Randomised Double-masked Clinical Trial: Assessing Morning Versus Evening Dosing of a Fixed Dose Combination of Travoprost 0.004% / Timolol Maleate 0.5% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00759239 Phase 4 Travoprost 0.004% / Timolol maleate 0.5%;Travoprost 0.004% / Timolol maleate 0.5%
26 Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP) Completed NCT01162603 Phase 4 TAFLUPROST 0.0015% EYEDROPS;LATANOPROST 0.005% EYEDROPS
27 A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma Completed NCT00911924 Phase 4
28 Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) Completed NCT00913029 Phase 4 latanoprost/timolol
29 A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Completed NCT00527592 Phase 4 Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®);Latanoprost ophthalmic solution 0.005% (XALATAN®)
30 A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma Completed NCT00887029 Phase 4 DuoTrav (travoprost-timolol ophthalmic drops);Xalacom (latanoprost-timolol ophthalmic drops)
31 Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Completed NCT02325518 Phase 4 Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension;Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution;Subject's habitual PGA monotherapy
32 Evaluation of Intraocular Pressure Using Simbrinzaâ„¢ in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed NCT01978600 Phase 4 Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension;Timolol Maleate 0.5%
33 Comparison of Istalolâ„¢ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Completed NCT00698945 Phase 4 Istalol and Optive;Alphagan
34 Safety of GANFORT® Ophthalmic Solution in Chinese Patients With Open-angle Glaucoma or Ocular Hypertension Completed NCT02571712 Phase 4 bimatoprost 0.03% plus timolol 0.5%
35 Efficacy and Safety of Travoprost 0.004% Versus Tafluprost 0.0015% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00966940 Phase 4 Travoprost 0.004% ophthalmic solution (TRAVATAN);Tafluprost 0.0015% ophthalmic solution
36 Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma Completed NCT00444080 Phase 4
37 Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN Completed NCT00798759 Phase 4 Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®);Latanoprost ophthalmic solution 0.005% (XALATAN®)
38 Travatan Versus Timoptic in Treating Open-angle Glaucoma or Ocular Hypertension Completed NCT00763061 Phase 4 Travoprost 0.004% Ophthalmic Solution (Travatan);Timolol 0.5% Ophthalmic Solution (Timoptic)
39 Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00372827 Phase 4 Brinzolamide 1% added to Travoprost 0.004%
40 A Study to Assess the Efficacy of 3 Months of Latanoprost Treatment in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma Completed NCT00647101 Phase 4 Latanoprost
41 Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00822081 Phase 4 brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination;dorzolamide hcl 2%/ timolol maleate 0.5% fixed combination;brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy.;dorzolamide hcl 2%/timolol maleate 0.5% fixed combinatin as adjunctive to current prostaglandin therapy.
42 Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00822055 Phase 4 brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination;dorzolamide hcl 2%/timolol maleate 0.5% fixed combination;brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy;dorzolamide hcl 2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy
43 Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID) Completed NCT02167035 Phase 4 Combigan Two Times Daily (BID);Simbrinza Three Times Daily (TID)
44 Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study Completed NCT00698438 Phase 4
45 Efficacy And Safety of Pneumatic Trabeculoplasty Completed NCT01540331 Phase 4
46 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Completed NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
47 Patient Satisfaction With Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00804648 Phase 4 Timolol Maleate in Sorbate;Timolol hemihydrate;Timolol maleate gel forming solution
48 Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension Completed NCT03395535 Phase 4 Primary Medical Treatment Pathway
49 Efficacy of Travoprost/Timolol for Uncontrolled Intraocular Pressure Completed NCT02003391 Phase 4 Beta-blocker monotherapy;Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution
50 Efficacy And Safety Of Xalatan Compared To Usual Care In Patients With Open Angle Glaucoma Or Ocular Hypertension. Completed NCT00140062 Phase 4 latanoprost 0.005% (Xalatan)

Search NIH Clinical Center for Open-Angle Glaucoma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: glaucoma, open-angle

Sources

Genetic Tests for Open-Angle Glaucoma

About this section
Sources

Anatomical Context for Open-Angle Glaucoma

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MalaCards organs/tissues related to Open-Angle Glaucoma:

42
Eye, Testes, Endothelial, Bone, Brain, Retina, Cortex
Sources

Publications for Open-Angle Glaucoma

About this section

Articles related to Open-Angle Glaucoma:

(show top 50) (show all 3435)
# Title Authors Year
1
Prospective, Randomized, Controlled Pivotal Trial of iStent inject Trabecular Micro-Bypass in Primary Open-Angle Glaucoma and Cataract: Two-Year Results. ( 30880108 )
2019
2
Thiol-disulphide homeostasis and serum ischemia modified albumin levels in patients with primary open-angle glaucoma. ( 30868923 )
2019
3
Using healthcare databases to refine understanding of exploratory associations between drugs and progression of open angle glaucoma. ( 31038730 )
2019
4
Optic Disc Microhemorrhage in Primary Open-Angle Glaucoma: Clinical Implications for Visual Field Progression. ( 31042788 )
2019
5
Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients. ( 31043703 )
2019
6
Association of Statin Use and High Serum Cholesterol Levels With Risk of Primary Open-Angle Glaucoma. ( 31046067 )
2019
7
The Role of Statins and Cholesterol in the Primary Prevention of Primary Open-Angle Glaucoma. ( 31046110 )
2019
8
Surgical Outcomes of Phacoemulsification Followed by iStent Implantation Versus Goniotomy With the Kahook Dual Blade in Patients With Mild Primary Open-angle Glaucoma With a Minimum of 12-Month Follow-up. ( 31048639 )
2019
9
Intereye and intraeye asymmetry analysis of retinal microvascular and neural structure parameters for diagnosis of primary open-angle glaucoma. ( 31053800 )
2019
10
Can perforations of descemet's window (DW) improve the outcome of canaloplasty in open angle glaucoma? ( 31062146 )
2019
11
Combined machine learning and diffusion tensor imaging reveals altered anatomic fiber connectivity of the brain in primary open-angle glaucoma. ( 31071304 )
2019
12
Systematic Review of Economic Evaluations in Primary Open-Angle Glaucoma: Decision Analytic Modeling Insights. ( 31111447 )
2019
13
Linear discriminant score for differentiating early primary open angle glaucoma from glaucoma suspects. ( 30574897 )
2019
14
Commentary: Linear discriminant score for differentiating early primary open angle glaucoma from suspects. ( 30574898 )
2019
15
The impact of primary open-angle glaucoma: Comparison of vision-specific (National Eye Institute Visual Function Questionnaire-25) and disease-specific (Glaucoma Quality of Life-15 and Viswanathan 10) patient-reported outcome (PRO) instruments. ( 30574899 )
2019
16
Association of the SIX6 locus with primary open angle glaucoma in southern Chinese and Japanese. ( 30586556 )
2019
17
Corneal Endothelial Cell Density and Morphology After Phacoemulsification in Patients With Primary Open-Angle Glaucoma and Cataracts: 2-Year Results of a Randomized Multicenter Trial. ( 30614901 )
2019
18
Optical Coherence Tomography Angiography of Optic Disc in Eyes With Primary Open-angle Glaucoma and Normal-tension Glaucoma. ( 30624391 )
2019
19
The cost-effectiveness of medication, laser trabeculoplasty, and trabeculectomy for treatment of open-angle glaucoma in South Korea. ( 30633194 )
2019
20
Comparison between broadband and monochromatic photopic negative response in full-field electroretinogram in controls and subjects with primary open-angle glaucoma. ( 30635745 )
2019
21
Is primary open-angle glaucoma an ocular manifestation of systemic disease? ( 30643967 )
2019
22
Relationship between primary open angle glaucoma and blood pressure. ( 30650042 )
2019
23
Progressive retinal ganglion cell loss in primary open-angle glaucoma is associated with temperature circadian rhythm phase delay and compromised sleep. ( 30663431 )
2019
24
Cost-effectiveness analysis of standalone trabecular micro-bypass stents in patients with mild-to-moderate open-angle glaucoma in Canada. ( 30663456 )
2019
25
360° ab-interno trabeculotomy in refractory primary open-angle glaucoma. ( 30666087 )
2019
26
Peripapillary Vessel Density in Glaucomatous Eyes: Comparison Between Pseudoexfoliation Glaucoma and Primary Open-angle Glaucoma. ( 30676407 )
2019
27
Peripapillary Vessel Density in Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma. ( 30676410 )
2019
28
Potential Biomarkers for Primary Open-Angle Glaucoma Identified by Long Noncoding RNA Profiling in the Aqueous Humor. ( 30677397 )
2019
29
The Risk of Primary Open-Angle Glaucoma Following Vitreoretinal Surgery-A Population-based Study. ( 30683306 )
2019
30
XEN® Gel Stent for management of chronic open angle glaucoma: A review of the literature. ( 30683533 )
2019
31
The Risk of Primary Open-Angle Glaucoma Following Vitreoretinal Surgery-A Population-based Study. ( 30686476 )
2019
32
Peripapillary Vessel Density in Glaucomatous Eyes: Comparison Between Pseudoexfoliation Glaucoma and Primary Open-angle Glaucoma. ( 30688841 )
2019
33
Incidence of Open-angle Glaucoma in Newly Diagnosed Retinal Vein Occlusion: A Nationwide Population-based Study. ( 30689606 )
2019
34
Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma. ( 30707048 )
2019
35
Trabecular microbypass stent implantation in pseudophakic eyes with open-angle glaucoma: Long-term results. ( 30709629 )
2019
36
The EX-PRESS glaucoma shunt versus nonpenetrating deep sclerectomy with Esnoper implant in combined surgery for open-angle glaucoma: a prospective randomized study. ( 30714336 )
2019
37
Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Alzheimer's Disease: A Comparison of Eyes of Patients with Alzheimer's Disease, Primary Open-Angle Glaucoma, and Preperimetric Glaucoma and Healthy Controls. ( 30720005 )
2019
38
Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis. ( 30721926 )
2019
39
Analysis of pattern electroretinogram signals of early primary open-angle glaucoma in discrete wavelet transform coefficients domain. ( 30725244 )
2019
40
Polymorphism rs7961953 in TMTC2 gene is not associated with primary open-angle glaucoma in a Saudi cohort. ( 30729851 )
2019
41
Increased prelaminar tissue thickness in patients with open-angle glaucoma and type 2 diabetes. ( 30730917 )
2019
42
Comprehensive measurements of hydroxylinoleate and hydroxyarachidonate isomers in blood samples from primary open-angle glaucoma patients and controls. ( 30778084 )
2019
43
Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters. ( 30783031 )
2019
44
Ocular dialysis disequilibrium-Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature. ( 30785657 )
2019
45
Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma. ( 30786279 )
2019
46
Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study. ( 30790180 )
2019
47
Transient ciliochoroidal detachment after 360-degree suture trabeculotomy ab interno for open-angle glaucoma: 12-month follow-up. ( 30792522 )
2019
48
Endoscopic cyclophotocoagulation (ECP) for open angle glaucoma and primary angle closure. ( 30801132 )
2019
49
Diagnostic power of laser speckle flowgraphy-measured optic disc microcirculation for open-angle glaucoma: analysis of 314 eyes. ( 30801940 )
2019
50
Comparing the efficacy of trabeculectomy and diode laser cyclophotocoagulation in primary open-angle glaucoma. ( 30830546 )
2019
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Variations for Open-Angle Glaucoma

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Expression for Open-Angle Glaucoma

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Search GEO for disease gene expression data for Open-Angle Glaucoma.
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Pathways for Open-Angle Glaucoma

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Pathways related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 67
Show member pathways
 12.09 ELN LOXL1 LTBP2 MMP1 OPTC TGFB2
2
Elastic fibre formation 67
Show member pathways
 10.79 ELN LOXL1 LTBP2 TGFB2
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GO Terms for Open-Angle Glaucoma

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Cellular components related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 ELN LOXL1 LTBP2 TGFB2
2 extracellular matrix GO:0031012 9.02 ELN LOXL1 LTBP2 MMP1 OPTC

Biological processes related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.02 CRYAA CYP1B1 OPA1 SIX6 WDR36
2 positive regulation of xenophagy GO:1904417 8.96 OPTN TBK1

Molecular functions related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 ELN LTBP2 OPTC
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Sources for Open-Angle Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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