MCID: OPH002
MIFTS: 38

Ophthalmia Neonatorum

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Ophthalmia Neonatorum

MalaCards integrated aliases for Ophthalmia Neonatorum:

Name: Ophthalmia Neonatorum 12 15 73
Gonococcal Conjunctivitis 12 76 53 59
Gonococcal Ophthalmia Neonatorum 12 73
Neonatal Conjunctivitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9699
ICD10 33 P39.1
ICD9CM 35 771.6
NCIt 50 C116815
Orphanet 59 ORPHA1482
ICD10 via Orphanet 34 A54.3+ H13.1*
UMLS via Orphanet 74 C0339166

Summaries for Ophthalmia Neonatorum

MalaCards based summary : Ophthalmia Neonatorum, also known as gonococcal conjunctivitis, is related to chlamydia and selective igg deficiency disease. An important gene associated with Ophthalmia Neonatorum is GCNT2 (Glucosaminyl (N-Acetyl) Transferase 2 (I Blood Group)), and among its related pathways/superpathways is Primary immunodeficiency. The drugs silver nitrate and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include eye, appendix and testes.

Wikipedia : 76 Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of... more...

Related Diseases for Ophthalmia Neonatorum

Diseases related to Ophthalmia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 chlamydia 30.8 CD40LG CD79A
2 selective igg deficiency disease 10.4 CD40LG CD79A
3 c1q nephropathy 10.4 CD40LG CD79A
4 meningovascular neurosyphilis 10.4 CD40LG CD79A
5 alpha chain disease 10.4 CD40LG CD79A
6 brill-zinsser disease 10.4 CD40LG CD79A
7 exudative glomerulonephritis 10.4 CD40LG CD79A
8 cork-handlers' disease 10.4 CD40LG CD79A
9 salpingo-oophoritis 10.4 CD40LG CD79A
10 early yaws 10.4 CD40LG CD79A
11 ventilation pneumonitis 10.4 CD40LG CD79A
12 chronic interstitial cystitis 10.4 CD40LG CD79A
13 axillary adenitis 10.4 CD40LG CD79A
14 cryofibrinogenemia 10.4 CD40LG CD79A
15 trichostrongyloidiasis 10.4 CD40LG CD79A
16 subacute bacterial endocarditis 10.4 CD40LG CD79A
17 heterophyiasis 10.4 CD40LG CD79A
18 immunoglobulin g deficiency 10.4 CD40LG CD79A
19 orbital granuloma 10.4 CD40LG CD79A
20 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
21 hyperglobulinemic purpura 10.4 CD40LG CD79A
22 gastroduodenitis 10.4 CD40LG CD79A
23 heavy chain disease 10.4 CD40LG CD79A
24 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
25 parotid disease 10.4 CD40LG CD79A
26 cerebral arteritis 10.4 CD40LG CD79A
27 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
28 geniculate herpes zoster 10.4 CD40LG CD79A
29 erythema elevatum diutinum 10.4 CD40LG CD79A
30 sporotrichosis 10.4 CD40LG CD79A
31 fallopian tube disease 10.4 CD40LG CD79A
32 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A
33 congenital syphilis 10.4 CD40LG CD79A
34 polyclonal hypergammaglobulinemia 10.4 CD40LG CD79A
35 monoclonal paraproteinemia 10.4 CD40LG CD79A
36 salpingitis 10.4 CD40LG CD79A
37 ocular toxoplasmosis 10.4 CD40LG CD79A
38 dysgammaglobulinemia 10.4 CD40LG CD79A
39 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
40 acute maxillary sinusitis 10.4 CD40LG CD79A
41 chronic polyneuropathy 10.4 CD40LG CD79A
42 spinocerebellar ataxia, autosomal recessive 10 10.4 CD40LG CD79A
43 parasitic ichthyosporea infectious disease 10.4 CD40LG CD79A
44 cd40 ligand deficiency 10.4 CD40LG CD79A
45 rhinosporidiosis 10.4 CD40LG CD79A
46 secondary syphilis 10.4 CD40LG CD79A
47 vitamin b12 deficiency 10.4 CD79A MTR
48 yellow nail syndrome 10.4 CD40LG CD79A
49 congenital toxoplasmosis 10.4 CD40LG CD79A
50 chorioretinitis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Ophthalmia Neonatorum:



Diseases related to Ophthalmia Neonatorum

Symptoms & Phenotypes for Ophthalmia Neonatorum

Drugs & Therapeutics for Ophthalmia Neonatorum

Drugs for Ophthalmia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 silver nitrate Approved, Investigational Phase 3
2
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
3
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
4
Azithromycin Approved Phase 3 83905-01-5 55185 447043
5
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
6
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Erythromycin Estolate Phase 3
10 Erythromycin Ethylsuccinate Phase 3
11 Erythromycin stearate Phase 3
12 Anti-Infective Agents Phase 3
13 Anti-Infective Agents, Local Phase 3
14 Chloroquine diphosphate Phase 3 50-63-5
15 Analgesics Phase 3
16 Renal Agents Phase 3
17 Folic Acid Antagonists Phase 3
18 Analgesics, Non-Narcotic Phase 3
19 Anthelmintics Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Vitamin B Complex Phase 3
22 Fanasil, pyrimethamine drug combination Phase 3
23 Antiparasitic Agents Phase 3
24 Antiprotozoal Agents Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Anti-Inflammatory Agents, Non-Steroidal Phase 3
27 Antimalarials Phase 3
28 Antirheumatic Agents Phase 3
29 Folate Nutraceutical Phase 3
30 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
2 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
3 Conjunctivitis in the Newborn Completed NCT03528915

Search NIH Clinical Center for Ophthalmia Neonatorum

Genetic Tests for Ophthalmia Neonatorum

Anatomical Context for Ophthalmia Neonatorum

MalaCards organs/tissues related to Ophthalmia Neonatorum:

41
Eye, Appendix, Testes, Skin, Thyroid

Publications for Ophthalmia Neonatorum

Articles related to Ophthalmia Neonatorum:

(show top 50) (show all 265)
# Title Authors Year
1
Dacryoadenitis due to gonococcal conjunctivitis complicated by corneal perforation. ( 29565715 )
2018
2
Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus. ( 29351260 )
2018
3
Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the A9molecular ageA9: investigation for a correct therapy. ( 29504385 )
2018
4
The eyes have it: An unusual case of<i> <b>Escherichia coli</b> </i>ophthalmia neonatorum or a shifting landscape? ( 29276602 )
2017
5
Prevention of Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae Using a Fatty Acid-Based Formulation. ( 28743809 )
2017
6
Morganella as a cause of ophthalmia neonatorum. ( 29288840 )
2017
7
Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum. ( 26876399 )
2016
8
Gonococcal Conjunctivitis: A Case Report of an Unusual Mode of Transmission. ( 27871917 )
2016
9
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study. ( 26810921 )
2016
10
Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. ( 26760182 )
2016
11
Preventing ophthalmia neonatorum. ( 26236350 )
2015
12
Gonococcal conjunctivitis: the importance of good-quality conjunctival swabs. ( 26412834 )
2015
13
Preventing ophthalmia neonatorum. ( 25838784 )
2015
14
Klebsiella pneumonia: An unusual cause of ophthalmia neonatorum in a healthy newborn. ( 26691043 )
2015
15
Response to maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949092 )
2015
16
Prevalence of gonococcal conjunctivitis in adults and neonates. ( 25907207 )
2015
17
First attempt to implement ophthalmia neonatorum prophylaxis in angola: microorganisms, efficacy, and obstacles. ( 25785190 )
2015
18
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949091 )
2015
19
Ophthalmia neonatorum prophylaxis. ( 26257230 )
2015
20
Time trends in ophthalmia neonatorum and dacryocystitis of the newborn in England, 2000-2011: database study. ( 25512672 )
2014
21
Ophthalmia neonatorum prophylaxis and the 21st century antimicrobial resistance challenge. ( 25100901 )
2014
22
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25100909 )
2014
23
Treatment and prevention of ophthalmia neonatorum. ( 24235191 )
2013
24
Ocular prophylaxis for gonococcal ophthalmia neonatorum: reaffirmation recommendation statement. ( 22335221 )
2012
25
Povidone-iodine and ophthalmia neonatorum. ( 22385492 )
2012
26
Ophthalmia neonatorum: what kind of prophylaxis? ( 21534852 )
2011
27
Efficacy comparison between povidone iodine 2.5% and tetracycline 1% in prevention of ophthalmia neonatorum. ( 21439642 )
2011
28
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum. ( 20630358 )
2010
29
Cost analysis of povidone-iodine for ophthalmia neonatorum prophylaxis. ( 20065233 )
2010
30
Ophthalmia neonatorum. ( 20810051 )
2010
31
Ophthalmia neonatorum: a vanishing disease or underreported notification? ( 19079151 )
2009
32
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology. ( 18227767 )
2008
33
Images in emergency medicine. Gonococcal conjunctivitis. ( 18565376 )
2008
34
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. ( 18093859 )
2008
35
Efficacy of topical ophthalmic prophylaxis in prevention of ophthalmia neonatorum. ( 17326893 )
2007
36
Chlamydia trachomatis serovars in Buenos Aires, Argentina: predominance of serovar E in ophthalmia neonatorum. ( 18032994 )
2007
37
Prophylaxis of ophthalmia neonatorum comparison of betadine, erythromycin and no prophylaxis. ( 18055489 )
2007
38
Effect of topical 1.25% povidone-iodine eyedrops used for prophylaxis of ophthalmia neonatorum on renal iodine excretion and thyroid-stimulating hormone level. ( 16615978 )
2006
39
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). ( 16088243 )
2005
40
Prophylaxis of ophthalmia neonatorum. ( 15377567 )
2004
41
Ophthalmia neonatorum caused by multidrug-resistant Neisseria gonorrhoeae. ( 15055278 )
2004
42
A case control study of ophthalmia Neonatorum in Kaduna II: causative agents and their antibiotic sensitivity. ( 15587832 )
2004
43
A double application approach to ophthalmia neonatorum prophylaxis. ( 14660449 )
2003
44
Povidone-iodine prophylaxis of ophthalmia neonatorum. ( 14660446 )
2003
45
Prophylaxis of ophthalmia neonatorum--a nationwide survey of the current practice in Austria. ( 12238308 )
2002
46
Ophthalmia neonatorum caused by group B Streptococcus. ( 12587626 )
2002
47
New aspects in prophylaxis of ophthalmia neonatorum (CredAc prophylaxis). ( 12238303 )
2002
48
Ophthalmia neonatorum associated with isoimmune neonatal neutropenia. ( 12051286 )
2002
49
Prophylactic indications for eye antiseptics. Prophylaxis against ophthalmia neonatorum. ( 12236114 )
2002
50
Is CredAc's prophylaxis for ophthalmia neonatorum still valid? ( 11285676 )
2001

Variations for Ophthalmia Neonatorum

Expression for Ophthalmia Neonatorum

Search GEO for disease gene expression data for Ophthalmia Neonatorum.

Pathways for Ophthalmia Neonatorum

Pathways related to Ophthalmia Neonatorum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Ophthalmia Neonatorum

Biological processes related to Ophthalmia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Ophthalmia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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