MCID: OPH002
MIFTS: 35

Ophthalmia Neonatorum

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Ophthalmia Neonatorum

MalaCards integrated aliases for Ophthalmia Neonatorum:

Name: Ophthalmia Neonatorum 12 15 74
Gonococcal Conjunctivitis 12 77 54 60
Gonococcal Ophthalmia Neonatorum 12 74
Neonatal Conjunctivitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9699
ICD9CM 36 771.6
NCIt 51 C116815
SNOMED-CT 69 34298002 80881003
ICD10 34 P39.1
ICD10 via Orphanet 35 A54.3+ H13.1*
UMLS via Orphanet 75 C0339166
Orphanet 60 ORPHA1482

Summaries for Ophthalmia Neonatorum

Disease Ontology : 12 A bacterial conjuctivitis that is characterized by pain and tenderness in the eyeball and conjuctival discharge.

MalaCards based summary : Ophthalmia Neonatorum, also known as gonococcal conjunctivitis, is related to chlamydia and conjunctivitis. An important gene associated with Ophthalmia Neonatorum is GCNT2 (Glucosaminyl (N-Acetyl) Transferase 2 (I Blood Group)). The drugs Erythromycin and silver nitrate have been mentioned in the context of this disorder. Affiliated tissues include eye, placenta and skin, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : 77 Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of... more...

Related Diseases for Ophthalmia Neonatorum

Diseases related to Ophthalmia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 chlamydia 10.6
2 conjunctivitis 10.4
3 trachoma 10.3
4 arthritis 10.1
5 neutropenia 10.1
6 chlamydia pneumonia 10.1
7 placenta praevia 10.1
8 klebsiella pneumonia 10.1
9 pneumonia 10.1
10 ritter's disease 10.1
11 dacryoadenitis 10.1
12 interstitial keratitis 10.1
13 dacryocystitis 10.1
14 haemophilus influenzae 10.1
15 orbital cellulitis 10.0
16 urethritis 10.0
17 cellulitis 10.0
18 bacterial conjunctivitis 9.9 GCNT2 MTR
19 cervix carcinoma 9.6 MAPK8IP1 STYK1

Graphical network of the top 20 diseases related to Ophthalmia Neonatorum:



Diseases related to Ophthalmia Neonatorum

Symptoms & Phenotypes for Ophthalmia Neonatorum

GenomeRNAi Phenotypes related to Ophthalmia Neonatorum according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 9.02 GCNT2
2 Decreased homologous recombination repair frequency GR00236-A-1 9.02 GCNT2 MAPK8IP1 NSMCE3
3 Decreased homologous recombination repair frequency GR00236-A-2 9.02 MAPK8IP1

Drugs & Therapeutics for Ophthalmia Neonatorum

Drugs for Ophthalmia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 441411 12560
2 silver nitrate Approved, Investigational Phase 3
3
Azithromycin Approved Phase 3 83905-01-5 447043 55185
4
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
5
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
6
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
7
leucovorin Approved Phase 3 58-05-9 143 6006
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Erythromycin Ethylsuccinate Phase 3
10 Erythromycin stearate Phase 3
11 Erythromycin Estolate Phase 3
12 Anti-Infective Agents, Local Phase 3
13 Anti-Infective Agents Phase 3
14 Vitamin B Complex Phase 3
15 Antiparasitic Agents Phase 3
16 Anti-Infective Agents, Urinary Phase 3
17 Folate Phase 3
18 Folic Acid Antagonists Phase 3
19 Chloroquine diphosphate Phase 3 50-63-5
20 Analgesics Phase 3
21 Vitamin B9 Phase 3
22 Analgesics, Non-Narcotic Phase 3
23 Fanasil, pyrimethamine drug combination Phase 3
24 Antimalarials Phase 3
25 Antirheumatic Agents Phase 3
26 Antiprotozoal Agents Phase 3
27 Anti-Inflammatory Agents Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30 Renal Agents Phase 3
31 Anthelmintics Phase 3
32 Antitubercular Agents
33 Ophthalmic Solutions
34 Antibiotics, Antitubercular
35 Anti-Bacterial Agents
36 rifamycin SV
37 Rifamycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
2 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
3 Prevalence of Conjunctivitis and Indentification of Risk Factors With and Without Prophylactic Antibiotic Treatment in Neonates Completed NCT03528915

Search NIH Clinical Center for Ophthalmia Neonatorum

Genetic Tests for Ophthalmia Neonatorum

Anatomical Context for Ophthalmia Neonatorum

MalaCards organs/tissues related to Ophthalmia Neonatorum:

42
Eye, Placenta, Skin, Testes, Thyroid, Uterus, Appendix

Publications for Ophthalmia Neonatorum

Articles related to Ophthalmia Neonatorum:

(show top 50) (show all 330)
# Title Authors Year
1
Has the increasing incidence of chlamydia and gonorrhoea resulted in increased chlamydial and gonococcal conjunctivitis presentations? Results from Melbourne, Australia, from 2000 to 2017. ( 30098131 )
2019
2
Ophthalmia Neonatorum. ( 30625059 )
2019
3
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. ( 30694309 )
2019
4
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement. ( 30694327 )
2019
5
Dacryoadenitis due to gonococcal conjunctivitis complicated by corneal perforation. ( 29565715 )
2018
6
Gonococcal Conjunctivitis in Adults: Case Report and Retrospective Review of Cases in Alberta, Canada, 2000-2016. ( 30044333 )
2018
7
Gonococcal conjunctivitis: A case report. ( 30800230 )
2018
8
Morganella as a cause of ophthalmia neonatorum. ( 29288840 )
2018
9
Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus. ( 29351260 )
2018
10
Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the molecular age: investigation for a correct therapy. ( 29504385 )
2018
11
A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices. ( 30413681 )
2018
12
Emergency management: ophthalmia neonatorum. ( 30487681 )
2018
13
Gonococcal ophthalmia neonatorum: a case report. ( 30799834 )
2018
14
Gonococcal Conjunctivitis: A Case Report of an Unusual Mode of Transmission. ( 27871917 )
2017
15
Prevention of Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae Using a Fatty Acid-Based Formulation. ( 28743809 )
2017
16
The eyes have it: An unusual case of Escherichia coli ophthalmia neonatorum or a shifting landscape? ( 29276602 )
2017
17
Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. ( 26760182 )
2016
18
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study. ( 26810921 )
2016
19
Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum. ( 26876399 )
2016
20
Prevalence of gonococcal conjunctivitis in adults and neonates. ( 25907207 )
2015
21
Corneal complication caused by gonococcal conjunctivitis. ( 26018149 )
2015
22
Gonococcal conjunctivitis: the importance of good-quality conjunctival swabs. ( 26412834 )
2015
23
Time trends in ophthalmia neonatorum and dacryocystitis of the newborn in England, 2000-2011: database study. ( 25512672 )
2015
24
Klebsiella pneumonia: An unusual cause of ophthalmia neonatorum in a healthy newborn. ( 26691043 )
2015
25
First attempt to implement ophthalmia neonatorum prophylaxis in angola: microorganisms, efficacy, and obstacles. ( 25785190 )
2015
26
Preventing ophthalmia neonatorum. ( 25838784 )
2015
27
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949091 )
2015
28
Response to maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949092 )
2015
29
Preventing ophthalmia neonatorum. ( 26236350 )
2015
30
Ophthalmia neonatorum prophylaxis. ( 26257230 )
2015
31
Ophthalmia neonatorum prophylaxis and the 21st century antimicrobial resistance challenge. ( 25100901 )
2014
32
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25100909 )
2014
33
Treatment and prevention of ophthalmia neonatorum. ( 24235191 )
2013
34
Ocular prophylaxis for gonococcal ophthalmia neonatorum: reaffirmation recommendation statement. ( 22335221 )
2012
35
Povidone-iodine and ophthalmia neonatorum. ( 22385492 )
2012
36
Efficacy comparison between povidone iodine 2.5% and tetracycline 1% in prevention of ophthalmia neonatorum. ( 21439642 )
2011
37
Ophthalmia neonatorum: what kind of prophylaxis? ( 21534852 )
2011
38
Cost analysis of povidone-iodine for ophthalmia neonatorum prophylaxis. ( 20065233 )
2010
39
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum. ( 20630358 )
2010
40
Ophthalmia neonatorum. ( 20810051 )
2010
41
Ophthalmia neonatorum: a vanishing disease or underreported notification? ( 19079151 )
2009
42
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. ( 18093859 )
2008
43
Images in emergency medicine. Gonococcal conjunctivitis. ( 18565376 )
2008
44
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology. ( 18227767 )
2008
45
Efficacy of topical ophthalmic prophylaxis in prevention of ophthalmia neonatorum. ( 17326893 )
2007
46
Chlamydia trachomatis serovars in Buenos Aires, Argentina: predominance of serovar E in ophthalmia neonatorum. ( 18032994 )
2007
47
Prophylaxis of ophthalmia neonatorum comparison of betadine, erythromycin and no prophylaxis. ( 18055489 )
2007
48
Bilateral corneal perforation in a sexually active adult male with gonococcal conjunctivitis. ( 17240593 )
2006
49
Effect of topical 1.25% povidone-iodine eyedrops used for prophylaxis of ophthalmia neonatorum on renal iodine excretion and thyroid-stimulating hormone level. ( 16615978 )
2006
50
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). ( 16088243 )
2005

Variations for Ophthalmia Neonatorum

Expression for Ophthalmia Neonatorum

Search GEO for disease gene expression data for Ophthalmia Neonatorum.

Pathways for Ophthalmia Neonatorum

GO Terms for Ophthalmia Neonatorum

Sources for Ophthalmia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....