MCID: OPH002
MIFTS: 35

Ophthalmia Neonatorum

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ophthalmia Neonatorum

MalaCards integrated aliases for Ophthalmia Neonatorum:

Name: Ophthalmia Neonatorum 12 15 70
Gonococcal Conjunctivitis 12 73 20 58
Gonococcal Ophthalmia Neonatorum 12 70
Neonatal Conjunctivitis 12

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9699
ICD9CM 34 771.6
NCIt 50 C116815
SNOMED-CT 67 206345004 80881003
ICD10 32 P39.1
ICD10 via Orphanet 33 A54.3+ H13.1*
UMLS via Orphanet 71 C0339166
Orphanet 58 ORPHA1482
UMLS 70 C0027611 C0029076 C0339166

Summaries for Ophthalmia Neonatorum

Disease Ontology : 12 A bacterial conjuctivitis that is characterized by pain and tenderness in the eyeball and conjuctival discharge.

MalaCards based summary : Ophthalmia Neonatorum, also known as gonococcal conjunctivitis, is related to bacterial conjunctivitis and inclusion conjunctivitis. An important gene associated with Ophthalmia Neonatorum is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Diseases of metabolism and Cobalamin (Cbl, vitamin B12) transport and metabolism. The drugs silver nitrate and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include eye, uterus and placenta.

Wikipedia : 73 Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of... more...

Related Diseases for Ophthalmia Neonatorum

Diseases related to Ophthalmia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 bacterial conjunctivitis 30.7 SIGLEC5 MTRR CEACAM3
2 inclusion conjunctivitis 30.5 SPAG8 HTRA1 FBXO39
3 urethritis 30.3 MTRR MTR
4 salpingitis 30.2 SIGLEC5 SCARF1
5 conjunctivitis 10.9
6 chlamydia 10.9
7 yemenite deaf-blind hypopigmentation syndrome 10.6
8 endometritis 10.3
9 trachoma 10.3
10 keratitis, hereditary 10.3
11 eye disease 10.3
12 lacrimal duct defect 10.2
13 chlamydia pneumonia 10.2
14 haemophilus influenzae 10.2
15 granuloma inguinale 10.1 SPAG8 FBXO39
16 lymphogranuloma venereum 10.1 SPAG8 FBXO39
17 methylmalonic aciduria and homocystinuria type cblg 10.0 MTRR MTR
18 methylmalonic aciduria and homocystinuria type cble 10.0 MTRR MTR
19 fallopian tube disease 10.0 SIGLEC5 MTRR CEACAM3
20 strabismus 10.0
21 pelvic inflammatory disease 10.0
22 superficial keratitis 10.0
23 neutropenia 10.0
24 klebsiella pneumonia 10.0
25 candidiasis 10.0
26 trichomoniasis 10.0
27 vaginitis 10.0
28 cervicitis 10.0
29 severe acute respiratory syndrome 10.0
30 vaginal discharge 10.0
31 rhinitis 10.0
32 pneumonia 10.0
33 arthritis 10.0
34 herpes simplex 10.0
35 ritter's disease 10.0
36 mechanical strabismus 10.0
37 dacryoadenitis 10.0
38 interstitial keratitis 10.0
39 dacryocystitis 10.0
40 inflammatory myopathy with abundant macrophages 10.0
41 methotrexate toxicity 10.0 MTRR MTR
42 anus disease 10.0 SIGLEC5 MTRR CEACAM3
43 urethral syndrome 10.0 SIGLEC5 MTRR CEACAM3
44 disorders of intracellular cobalamin metabolism 10.0 MTRR MTR
45 vitamin metabolic disorder 10.0 MTRR MTR
46 neural tube defects, folate-sensitive 10.0 MTRR MTR
47 vitamin b12 deficiency 10.0 MTRR MTR
48 otitis media 10.0
49 hypopyon 10.0
50 orbital cellulitis 10.0

Graphical network of the top 20 diseases related to Ophthalmia Neonatorum:



Diseases related to Ophthalmia Neonatorum

Symptoms & Phenotypes for Ophthalmia Neonatorum

Drugs & Therapeutics for Ophthalmia Neonatorum

Drugs for Ophthalmia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
silver nitrate Approved, Investigational Phase 3 7761-88-8
2
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Anti-Infective Agents, Local Phase 3
6 Gastrointestinal Agents Phase 3
7 Erythromycin Estolate Phase 3
8 Erythromycin stearate Phase 3
9 Erythromycin Ethylsuccinate Phase 3
10 Antirheumatic Agents
11 Antibiotics, Antitubercular
12 Ophthalmic Solutions
13 Rifamycins
14 rifamycin SV

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
2 Conjunctivitis Incidence in the Newborn Within the First Week of Life: Impact of the Prophylactic Use of Rifamycine(CRY NOT). Completed NCT03528915

Search NIH Clinical Center for Ophthalmia Neonatorum

Genetic Tests for Ophthalmia Neonatorum

Anatomical Context for Ophthalmia Neonatorum

MalaCards organs/tissues related to Ophthalmia Neonatorum:

40
Eye, Uterus, Placenta, Appendix

Publications for Ophthalmia Neonatorum

Articles related to Ophthalmia Neonatorum:

(show top 50) (show all 506)
# Title Authors PMID Year
1
[Gonococcal ophthalmia neonatorum: Case report]. 61
33388187 2021
2
Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis. 61
33436505 2021
3
Ophthalmia neonatorum as the presenting sign of SARS-CoV-2. 61
33774164 2021
4
Using Historical Data to Support Approval of Drug Products for Ophthalmia Neonatorum: Innovative Approach Toward Evidence-Based Medicine. 61
33331874 2021
5
Ophthalmia neonatorum in a tertiary referral children's hospital: A retrospective study. 61
33583215 2021
6
Relative frequencies of ophthalmia neonatorum and congenital nasolacrimal duct obstruction. 61
33509832 2021
7
Outcome of vision screening by community health workers at immunization outlets in Nigeria to support access to early visual evaluation in children aged 0-2 years. 61
33767959 2021
8
Prophylaxis for ophthalmia neonatorum in Brazil: A snapshot using a multi-professional national survey. 61
32894255 2021
9
Ophthalmia neonatorum and the role of primary care. 61
33243922 2020
10
Herpes simplex ophthalmia neonatorum: a sight-threatening diagnosis. 61
33004377 2020
11
Interventions for preventing ophthalmia neonatorum. 61
32959365 2020
12
Congenital Eyelid Imbrication Syndrome Mimicking Ophthalmia Neonatorum. 61
32687214 2020
13
Primary Eye Care in Eastern Nepal. 61
31842661 2020
14
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Recommendation Statement. 61
31414777 2019
15
Has the increasing incidence of chlamydia and gonorrhoea resulted in increased chlamydial and gonococcal conjunctivitis presentations? Results from Melbourne, Australia, from 2000 to 2017. 61
30098131 2019
16
Dacryoadenitis due to gonococcal conjunctivitis complicated by corneal perforation. 61
29565715 2019
17
Gonococcal Conjunctivitis in Adults: Case Report and Retrospective Review of Cases in Alberta, Canada, 2000-2016. 61
30044333 2019
18
Gonococcal conjunctivitis after incomplete treatment of gonococcal urethritis. 61
31213856 2019
19
Ophthalmia Neonatorum. 61
30625059 2019
20
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. 61
30694309 2019
21
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement. 61
30694327 2019
22
Gonococcal ophthalmia neonatorum: a case report. 61
30799834 2018
23
Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae, Mycoplasma genitalium, M. hominis, Ureaplasma urealyticum and U. parvum: a systematic review and meta-analysis protocol. 61
30498048 2018
24
A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices. 61
30413681 2018
25
A rare ocular complication of neisseria gonorrhoeae. 61
29349557 2018
26
The Growing Threat of Gonococcal Blindness. 61
30002340 2018
27
Aetiology of neonatal conjunctivitis evaluated in a population-based setting. 61
29345007 2018
28
Antibiotics for treating gonorrhoea in pregnancy. 61
29465747 2018
29
Integrating primary eye care into global child health policies. 61
28988214 2018
30
Morganella as a cause of ophthalmia neonatorum. 61
29288840 2018
31
Emergency management: ophthalmia neonatorum. 61
30487681 2018
32
Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus. 61
29351260 2018
33
Mutations in Neisseria gonorrhoeae grown in sub-lethal concentrations of monocaprin do not confer resistance. 61
29621310 2018
34
Gonococcal conjunctivitis: A case report. 61
30800230 2018
35
The use of povidone-iodine in ophthalmology. 61
28984794 2018
36
Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the molecular age: investigation for a correct therapy. 61
29504385 2018
37
Causes of Childhood Vision Impairment in the School for the Blind in Eritrea. 61
29053488 2017
38
Management of Extraocular Infections. 61
28707045 2017
39
Gonococcal Conjunctivitis: A Case Report of an Unusual Mode of Transmission. 61
27871917 2017
40
Prevention of Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae Using a Fatty Acid-Based Formulation. 61
28743809 2017
41
Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary. 61
28693667 2017
42
The eyes have it: An unusual case of Escherichia coli ophthalmia neonatorum or a shifting landscape? 61
29276602 2017
43
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study. 61
26810921 2016
44
[Gonococcal ophthalmia neonatorum: Clinical illustration, prevention, and future prospects]. 61
26850150 2016
45
Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum. 61
26876399 2016
46
Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. 61
26760182 2016
47
Acute bacterial conjunctivitis - antibiotic susceptibility and resistance to commercially available topical antibiotics in Nepal. 61
28242882 2016
48
Klebsiella pneumonia: An unusual cause of ophthalmia neonatorum in a healthy newborn. 61
26691043 2015
49
Gonococcus - The culprit of refractory, severe conjunctivitis in an elderly patient. 61
25980791 2015
50
Gonococcal conjunctivitis: the importance of good-quality conjunctival swabs. 61
26412834 2015

Variations for Ophthalmia Neonatorum

Expression for Ophthalmia Neonatorum

Search GEO for disease gene expression data for Ophthalmia Neonatorum.

GO Terms for Ophthalmia Neonatorum

Biological processes related to Ophthalmia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 9.26 MTRR MTR
2 cobalamin metabolic process GO:0009235 9.16 MTRR MTR
3 methionine biosynthetic process GO:0009086 8.96 MTRR MTR
4 sulfur amino acid metabolic process GO:0000096 8.62 MTRR MTR

Sources for Ophthalmia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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