MCID: OPH002
MIFTS: 32

Ophthalmia Neonatorum

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Ophthalmia Neonatorum

MalaCards integrated aliases for Ophthalmia Neonatorum:

Name: Ophthalmia Neonatorum 12 15 73
Gonococcal Conjunctivitis 12 76 53 59
Gonococcal Ophthalmia Neonatorum 12 73
Neonatal Conjunctivitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9699
ICD10 33 P39.1
ICD9CM 35 771.6
NCIt 50 C116815
SNOMED-CT 68 34298002 80881003
Orphanet 59 ORPHA1482
ICD10 via Orphanet 34 A54.3+ H13.1*
UMLS via Orphanet 74 C0339166

Summaries for Ophthalmia Neonatorum

Disease Ontology : 12 A bacterial conjuctivitis that is characterized by pain and tenderness in the eyeball and conjuctival discharge.

MalaCards based summary : Ophthalmia Neonatorum, also known as gonococcal conjunctivitis, is related to chlamydia and conjunctivitis. An important gene associated with Ophthalmia Neonatorum is GCNT2 (Glucosaminyl (N-Acetyl) Transferase 2 (I Blood Group)). The drugs Erythromycin and silver nitrate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Wikipedia : 76 Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of... more...

Related Diseases for Ophthalmia Neonatorum

Diseases related to Ophthalmia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 chlamydia 10.6
2 conjunctivitis 10.4
3 trachoma 10.3
4 arthritis 10.1
5 neutropenia 10.1
6 placenta praevia 10.1
7 klebsiella pneumonia 10.1
8 pneumonia 10.1
9 ritter's disease 10.1
10 interstitial keratitis 10.1
11 dacryocystitis 10.1
12 haemophilus influenzae 10.1
13 orbital cellulitis 10.0
14 urethritis 10.0
15 cellulitis 10.0
16 dacryoadenitis 10.0
17 bacterial conjunctivitis 9.9 GCNT2 MTR
18 cervix carcinoma 9.8 MAPK8IP1 STYK1

Graphical network of the top 20 diseases related to Ophthalmia Neonatorum:



Diseases related to Ophthalmia Neonatorum

Symptoms & Phenotypes for Ophthalmia Neonatorum

Drugs & Therapeutics for Ophthalmia Neonatorum

Drugs for Ophthalmia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
2 silver nitrate Approved, Investigational Phase 3
3
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
4
Azithromycin Approved Phase 3 83905-01-5 55185 447043
5
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
6
leucovorin Approved Phase 3 58-05-9 6006 143
7
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Erythromycin Ethylsuccinate Phase 3
10 Erythromycin stearate Phase 3
11 Anti-Infective Agents Phase 3
12 Erythromycin Estolate Phase 3
13 Anti-Infective Agents, Local Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Antiprotozoal Agents Phase 3
16 Chloroquine diphosphate Phase 3 50-63-5
17 Renal Agents Phase 3
18 Folic Acid Antagonists Phase 3
19 Fanasil, pyrimethamine drug combination Phase 3
20 Anti-Infective Agents, Urinary Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Vitamin B Complex Phase 3
23 Analgesics Phase 3
24 Antiparasitic Agents Phase 3
25 Antimalarials Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Antirheumatic Agents Phase 3
28 Analgesics, Non-Narcotic Phase 3
29 Folate Phase 3
30 Anthelmintics Phase 3
31 Vitamin B9 Phase 3
32 Antibiotics, Antitubercular
33 Ophthalmic Solutions
34 rifamycin SV
35 Rifamycins
36 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
2 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
3 Prevalence of Conjunctivitis and Indentification of Risk Factors With and Without Prophylactic Antibiotic Treatment in Neonates Completed NCT03528915

Search NIH Clinical Center for Ophthalmia Neonatorum

Genetic Tests for Ophthalmia Neonatorum

Anatomical Context for Ophthalmia Neonatorum

MalaCards organs/tissues related to Ophthalmia Neonatorum:

41
Eye, Skin, Testes, Thyroid, Placenta, Uterus, Cervix

Publications for Ophthalmia Neonatorum

Articles related to Ophthalmia Neonatorum:

(show top 50) (show all 325)
# Title Authors Year
1
Dacryoadenitis due to gonococcal conjunctivitis complicated by corneal perforation. ( 29565715 )
2018
2
Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus. ( 29351260 )
2018
3
Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the A9molecular ageA9: investigation for a correct therapy. ( 29504385 )
2018
4
Has the increasing incidence of chlamydia and gonorrhoea resulted in increased chlamydial and gonococcal conjunctivitis presentations? Results from Melbourne, Australia, from 2000 to 2017. ( 30098131 )
2018
5
Gonococcal Conjunctivitis in Adults: Case Report and Retrospective Review of Cases in Alberta, Canada, 2000-2016. ( 30044333 )
2018
6
A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices. ( 30413681 )
2018
7
Emergency management: ophthalmia neonatorum. ( 30487681 )
2018
8
The eyes have it: An unusual case of<i> <b>Escherichia coli</b> </i>ophthalmia neonatorum or a shifting landscape? ( 29276602 )
2017
9
Prevention of Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae Using a Fatty Acid-Based Formulation. ( 28743809 )
2017
10
Morganella as a cause of ophthalmia neonatorum. ( 29288840 )
2017
11
Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum. ( 26876399 )
2016
12
Gonococcal Conjunctivitis: A Case Report of an Unusual Mode of Transmission. ( 27871917 )
2016
13
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study. ( 26810921 )
2016
14
Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. ( 26760182 )
2016
15
Preventing ophthalmia neonatorum. ( 26236350 )
2015
16
Gonococcal conjunctivitis: the importance of good-quality conjunctival swabs. ( 26412834 )
2015
17
Preventing ophthalmia neonatorum. ( 25838784 )
2015
18
Klebsiella pneumonia: An unusual cause of ophthalmia neonatorum in a healthy newborn. ( 26691043 )
2015
19
Response to maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949092 )
2015
20
Prevalence of gonococcal conjunctivitis in adults and neonates. ( 25907207 )
2015
21
First attempt to implement ophthalmia neonatorum prophylaxis in angola: microorganisms, efficacy, and obstacles. ( 25785190 )
2015
22
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25949091 )
2015
23
Ophthalmia neonatorum prophylaxis. ( 26257230 )
2015
24
Corneal complication caused by gonococcal conjunctivitis. ( 26018149 )
2015
25
Time trends in ophthalmia neonatorum and dacryocystitis of the newborn in England, 2000-2011: database study. ( 25512672 )
2014
26
Ophthalmia neonatorum prophylaxis and the 21st century antimicrobial resistance challenge. ( 25100901 )
2014
27
Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi. ( 25100909 )
2014
28
Treatment and prevention of ophthalmia neonatorum. ( 24235191 )
2013
29
Ocular prophylaxis for gonococcal ophthalmia neonatorum: reaffirmation recommendation statement. ( 22335221 )
2012
30
Povidone-iodine and ophthalmia neonatorum. ( 22385492 )
2012
31
Ophthalmia neonatorum: what kind of prophylaxis? ( 21534852 )
2011
32
Efficacy comparison between povidone iodine 2.5% and tetracycline 1% in prevention of ophthalmia neonatorum. ( 21439642 )
2011
33
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum. ( 20630358 )
2010
34
Cost analysis of povidone-iodine for ophthalmia neonatorum prophylaxis. ( 20065233 )
2010
35
Ophthalmia neonatorum. ( 20810051 )
2010
36
Ophthalmia neonatorum: a vanishing disease or underreported notification? ( 19079151 )
2009
37
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology. ( 18227767 )
2008
38
Images in emergency medicine. Gonococcal conjunctivitis. ( 18565376 )
2008
39
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. ( 18093859 )
2008
40
Efficacy of topical ophthalmic prophylaxis in prevention of ophthalmia neonatorum. ( 17326893 )
2007
41
Chlamydia trachomatis serovars in Buenos Aires, Argentina: predominance of serovar E in ophthalmia neonatorum. ( 18032994 )
2007
42
Prophylaxis of ophthalmia neonatorum comparison of betadine, erythromycin and no prophylaxis. ( 18055489 )
2007
43
Effect of topical 1.25% povidone-iodine eyedrops used for prophylaxis of ophthalmia neonatorum on renal iodine excretion and thyroid-stimulating hormone level. ( 16615978 )
2006
44
Bilateral corneal perforation in a sexually active adult male with gonococcal conjunctivitis. ( 17240593 )
2006
45
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). ( 16088243 )
2005
46
Prophylaxis of ophthalmia neonatorum. ( 15377567 )
2004
47
Ophthalmia neonatorum caused by multidrug-resistant Neisseria gonorrhoeae. ( 15055278 )
2004
48
A case control study of ophthalmia Neonatorum in Kaduna II: causative agents and their antibiotic sensitivity. ( 15587832 )
2004
49
A double application approach to ophthalmia neonatorum prophylaxis. ( 14660449 )
2003
50
Povidone-iodine prophylaxis of ophthalmia neonatorum. ( 14660446 )
2003

Variations for Ophthalmia Neonatorum

Expression for Ophthalmia Neonatorum

Search GEO for disease gene expression data for Ophthalmia Neonatorum.

Pathways for Ophthalmia Neonatorum

GO Terms for Ophthalmia Neonatorum

Sources for Ophthalmia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....