Aliases & Classifications for Opioid Dependence 1

MalaCards integrated aliases for Opioid Dependence 1:

Name: Opioid Dependence 1 58 30 6
Opioid Dependence, Susceptibility to, 1 58 13
Dependence, Opioid, Susceptibility to 1 41
Ods1 58

External Ids:

OMIM 58 610064

Summaries for Opioid Dependence 1

MalaCards based summary : Opioid Dependence 1, also known as opioid dependence, susceptibility to, 1, is related to opiate dependence. An important gene associated with Opioid Dependence 1 is ODS1 (Opioid Dependence, Susceptibility To, 1). Affiliated tissues include brain.

Description from OMIM: 610064

Related Diseases for Opioid Dependence 1

Diseases related to Opioid Dependence 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 opiate dependence 11.1

Symptoms & Phenotypes for Opioid Dependence 1

Clinical features from OMIM:

610064

Drugs & Therapeutics for Opioid Dependence 1

Search Clinical Trials , NIH Clinical Center for Opioid Dependence 1

Genetic Tests for Opioid Dependence 1

Genetic tests related to Opioid Dependence 1:

# Genetic test Affiliating Genes
1 Opioid Dependence 1 30

Anatomical Context for Opioid Dependence 1

MalaCards organs/tissues related to Opioid Dependence 1:

42
Brain

Publications for Opioid Dependence 1

Articles related to Opioid Dependence 1:

(show all 12)
# Title Authors Year
1
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. ( 19528658 )
2009
2
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. ( 16387451 )
2006
3
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. ( 16682632 )
2006
4
The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers. ( 16906017 )
2006
5
Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. ( 16046395 )
2005
6
Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. ( 15037869 )
2004
7
Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. ( 15086512 )
2004
8
A polymorphism (A118G) in the mu-opioid receptor gene affects the response to morphine-6-glucuronide in humans. ( 11773858 )
2002
9
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. ( 11773859 )
2002
10
Opioid receptor and peptide gene polymorphisms: potential implications for addictions. ( 11134674 )
2000
11
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. ( 9689128 )
1998
12
Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine. ( 9193881 )
1997

Variations for Opioid Dependence 1

ClinVar genetic disease variations for Opioid Dependence 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 OPRM1 NM_001008503.2(OPRM1): c.118A> G (p.Asn40Asp) single nucleotide variant drug response rs1799971 GRCh37 Chromosome 6, 154360797: 154360797
2 OPRM1 NM_001008503.2(OPRM1): c.118A> G (p.Asn40Asp) single nucleotide variant drug response rs1799971 GRCh38 Chromosome 6, 154039662: 154039662

Expression for Opioid Dependence 1

Search GEO for disease gene expression data for Opioid Dependence 1.

Pathways for Opioid Dependence 1

GO Terms for Opioid Dependence 1

Sources for Opioid Dependence 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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