MCID: OPS001
MIFTS: 44

Opisthorchiasis

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases

Aliases & Classifications for Opisthorchiasis

MalaCards integrated aliases for Opisthorchiasis:

Name: Opisthorchiasis 12 53 55 44 15 73
Infection Due to Cat Liver Fluke 53
Infection Due to Opisthorchis 53
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD10 33 B66.0
ICD9CM 35 121.0
MeSH 44 D009889
SNOMED-CT 68 1059007
UMLS 73 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to fascioliasis and clonorchiasis. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways/superpathways are Allograft rejection and Influenza A. Affiliated tissues include liver, pancreas and lung.

Wikipedia : 76 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 fascioliasis 30.5 GPT IL1B
2 clonorchiasis 30.4 CTSF CXCL8 TNF
3 hepatitis 30.2 AFP GPT TNF
4 viral hepatitis 29.8 AFP GPT TNF
5 liver disease 29.8 AFP GPT TNF
6 hepatitis b 29.8 AFP GPT TNF
7 obstructive jaundice 29.7 CXCL8 GPT TNF
8 psoriasis 29.7 CXCL8 IL1B IL4 TNF
9 viral infectious disease 29.6 CXCL8 GPT IL1B IL4 TNF
10 cholangiocarcinoma 10.6
11 autoimmune vasculitis 10.2 IL1B IL4
12 diversion colitis 10.2 IL1B IL4
13 intrahepatic cholangiocarcinoma 10.2
14 adult dermatomyositis 10.2 GPT TNF
15 staphylococcal toxic shock syndrome 10.2 IL1B TNF
16 kashin-beck disease 10.2 IL1B TNF
17 rheumatoid lung disease 10.2 IL1B TNF
18 vulvar vestibulitis syndrome 10.2 IL1B TNF
19 burns 10.2 IL1B TNF
20 glossitis 10.2 IL1B TNF
21 laryngitis 10.2 IL1B TNF
22 tropical endomyocardial fibrosis 10.2 IL4 TNF
23 endomyocardial fibrosis 10.2 IL4 TNF
24 retinitis pigmentosa 60 10.2 IL1B TNF
25 irritant dermatitis 10.2 IL1B TNF
26 acute vascular insufficiency of intestine 10.1 IL1B TNF
27 congenital cytomegalovirus 10.1 IL1B TNF
28 actinic prurigo 10.1 IL1B TNF
29 autoimmune myocarditis 10.1 IL4 TNF
30 osteosclerotic myeloma 10.1 IL1B TNF
31 nonalcoholic steatohepatitis 10.1 GPT TNF
32 poems syndrome 10.1 IL1B TNF
33 periapical periodontitis 10.1 IL1B TNF
34 scleritis 10.1 IL4 TNF
35 central nervous system vasculitis 10.1 IL1B TNF
36 stachybotrys chartarum 10.1 IL1B TNF
37 jejunoileitis 10.1 IL1B TNF
38 recurrent corneal erosion 10.1 CXCL8 IL1B
39 bagassosis 10.1 CXCL8 IL1B
40 peptic esophagitis 10.1 CXCL8 IL1B
41 autoimmune gastritis 10.1 IL4 TNF
42 hemorrhagic fever 10.1 GPT TNF
43 funisitis 10.1 CXCL8 IL1B
44 ascaris lumbricoides infection 10.1 CXCL8 IL1B
45 blau syndrome 10.1 IL1B TNF
46 papillary conjunctivitis 10.1 CXCL8 IL4
47 orofacial granulomatosis 10.1 IL4 TNF
48 giant papillary conjunctivitis 10.1 CXCL8 IL4
49 mycoplasma pneumoniae pneumonia 10.1 IL4 TNF
50 poliomyelitis 10.1 IL4 TNF

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

41
Liver, Pancreas, Lung, Skin, Bone, Prostate, Placenta

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 190)
# Title Authors Year
1
Evaluation of a short term effect of praziquantel treatment in opisthorchiasis-induced hepatobiliary inflammation by urinary 8-oxodG. ( 30321522 )
2019
2
Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer. ( 29907253 )
2018
3
Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease. ( 29953446 )
2018
4
Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis. ( 29637887 )
2018
5
Opisthorchiasis and viral hepatitis b: clinical cases. ( 29602941 )
2018
6
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia. ( 29765958 )
2018
7
Acute Opisthorchiasis in a Kazakh Man. ( 29911767 )
2018
8
Analysis of a school-based health education model to prevent opisthorchiasis and cholangiocarcinoma in primary school children in northeast Thailand. ( 29809091 )
2018
9
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. ( 29649604 )
2018
10
Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma. ( 30442312 )
2018
11
Contraception, opisthorchiasis, and cholangiocarcinoma. ( 30249915 )
2018
12
Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study. ( 30139338 )
2018
13
Never seen before? Opisthorchiasis and Clonorchiasis. ( 30466135 )
2018
14
Behaviour and eating habits as determinants for human opisthorchiasis in the Bolsena Lake area, Italy. ( 30348910 )
2018
15
Opisthorchiasis and the Microbiome. ( 30442306 )
2018
16
Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus). ( 29088234 )
2017
17
Social network analysis of food sharing among households in opisthorchiasis endemic villages of Lawa Lake, Thailand. ( 28188767 )
2017
18
Opisthorchiasis, hypercholesterolemia, and cholangiocarcinoma: A reappraisal. ( 28413795 )
2017
19
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis. ( 28429227 )
2017
20
Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem. ( 28848361 )
2017
21
Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. ( 28198451 )
2017
22
Ultrasonographic features of hepatobiliary in opisthorchiasis. ( 27956092 )
2016
23
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. ( 27576001 )
2016
24
PREVLENCE AND RISK FACTORS FOR OPISTHORCHIS VIVERRINI INFECTION AMONG CATS AND DOGS IN SIX DISTRICTS SURROUNDING THE UBOLRATANA DAM, AN ENDEMIC AREA FOR HUMAN OPISTHORCHIASIS IN NORTHEASTERN THAILAND. ( 29634175 )
2016
25
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. ( 27140305 )
2016
26
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. ( 27507639 )
2016
27
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. ( 27939972 )
2016
28
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. ( 26817235 )
2016
29
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? ( 27919744 )
2016
30
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. ( 27890720 )
2016
31
DIAGNOSTICS AND TREATMENT OF OBSTRUCTIVE JAUNDICE AT CHRONIC OPISTHORCHIASIS. ( 30427642 )
2016
32
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. ( 27482325 )
2016
33
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. ( 26485024 )
2015
34
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. ( 25836376 )
2015
35
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. ( 26312563 )
2015
36
Opisthorchiasis: an overlooked danger. ( 25836334 )
2015
37
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. ( 26108023 )
2015
38
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. ( 25877389 )
2015
39
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. ( 26602874 )
2015
40
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. ( 26625799 )
2015
41
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. ( 26344868 )
2015
42
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. ( 25041016 )
2014
43
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. ( 25102053 )
2014
44
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. ( 25188119 )
2014
45
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. ( 24516289 )
2013
46
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. ( 24018821 )
2013
47
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. ( 24122204 )
2013
48
Development of a community-based approach to opisthorchiasis control. ( 24377646 )
2013
49
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. ( 23188705 )
2013
50
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. ( 24349600 )
2013

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 CXCL8 IL1B IL4 TNF
2
Show member pathways
12.62 CXCL8 IL1B IL4 TNF
3
Show member pathways
12.18 IL1B IL4 TNF
4
Show member pathways
12.13 CXCL8 IL1B IL4 TNF
5
Show member pathways
12.11 IL1B IL4 TNF
6
Show member pathways
12.11 CXCL8 IL1B IL4 TNF
7
Show member pathways
12.07 CXCL8 IL1B TNF
8 12.03 CXCL8 IL1B TNF
9
Show member pathways
11.95 CXCL8 IL1B IL4 TNF
10
Show member pathways
11.89 IL1B IL4 TNF
11 11.78 CXCL8 IL1B TNF
12 11.77 IL1B IL4 TNF
13 11.75 CXCL8 IL1B TNF
14 11.74 CXCL8 IL1B TNF
15 11.71 CXCL8 IL1B TNF
16 11.7 CXCL8 IL1B IL4 TNF
17 11.66 AFP CXCL8 IL4
18 11.64 IL1B IL4 TNF
19 11.61 CXCL8 IL1B IL4 TNF
20
Show member pathways
11.6 CXCL8 IL4 TNF
21 11.59 CXCL8 IL1B TNF
22
Show member pathways
11.5 CXCL8 IL1B TNF
23 11.43 CXCL8 IL1B TNF
24 11.34 CXCL8 IL1B TNF
25 11.31 IL1B IL4 MFGE8 TNF
26 11.22 IL1B TNF
27 11.22 IL1B TNF
28 11.16 IL1B TNF
29 11.09 IL1B IL4 TNF
30 11.06 CXCL8 IL1B IL4 TNF
31 11.03 CXCL8 TNF
32 11.01 IL1B IL4 TNF
33 10.99 CXCL8 IL1B IL4 TNF
34 10.98 IL1B TNF
35 10.91 CXCL8 TNF
36 10.86 CXCL8 IL1B IL4 TNF
37 10.83 IL1B TNF
38 10.61 CXCL8 IL1B IL4 TNF

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 CTSF GPT IL1B KRT9 MFGE8 MUC16
2 extracellular region GO:0005576 9.5 AFP CXCL8 IL1B IL4 MFGE8 MUC16
3 extracellular space GO:0005615 9.32 AFP CTSF CXCL8 GPT IL1B IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.87 CXCL8 IL1B IL4 TNF
2 regulation of signaling receptor activity GO:0010469 9.81 CXCL8 IL1B IL4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.75 CXCL8 IL1B TNF
4 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL1B IL4 TNF
5 protein kinase B signaling GO:0043491 9.62 IL1B TNF
6 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.61 IL1B TNF
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 IL1B TNF
8 positive regulation of interleukin-8 production GO:0032757 9.6 IL1B TNF
9 negative regulation of neurogenesis GO:0050768 9.59 IL1B TNF
10 positive regulation of neutrophil chemotaxis GO:0090023 9.58 CXCL8 IL1B
11 embryonic digestive tract development GO:0048566 9.56 CXCL8 TNF
12 negative regulation of lipid catabolic process GO:0050995 9.55 IL1B TNF
13 positive regulation of glial cell proliferation GO:0060252 9.54 IL1B TNF
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 IL1B TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 IL1B TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL1B TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
18 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
19 positive regulation of neuroinflammatory response GO:0150078 9.37 IL1B TNF
20 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
21 chronic inflammatory response to antigenic stimulus GO:0002439 9.26 IL1B TNF
22 sequestering of triglyceride GO:0030730 9.16 IL1B TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF
24 positive regulation of phagocytosis GO:0050766 8.8 IL1B MFGE8 TNF

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL1B IL4 TNF

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....