MCID: OPS001
MIFTS: 40

Opisthorchiasis

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases

Aliases & Classifications for Opisthorchiasis

MalaCards integrated aliases for Opisthorchiasis:

Name: Opisthorchiasis 12 52 54 43 15 17 71 32
Infection Due to Cat Liver Fluke 52
Infection Due to Opisthorchis 52
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD9CM 34 121.0
MeSH 43 D009889
SNOMED-CT 67 1059007
ICD10 32 B66.0
UMLS 71 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to cholangitis and duodenal ulcer. An important gene associated with Opisthorchiasis is GGT1 (Gamma-Glutamyltransferase 1), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Folate Metabolism. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 74 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.0 TNF GPT GGT1 CXCL8
2 duodenal ulcer 30.9 TNF IL1B CXCL8
3 peptic ulcer disease 30.9 TNF IL1B CXCL8
4 typhoid fever 30.7 TNF IL1B GPT GGT1
5 diarrhea 30.6 TNF IL1B GPT CXCL8
6 obstructive jaundice 30.6 TNF GPT GGT1 CXCL8
7 schistosomiasis 30.4 TNF IL4 GPT GGT1
8 dysentery 30.3 TNF IL1B CXCL8
9 parasitic helminthiasis infectious disease 30.3 TNF SERPINA3 IL4 EPGN
10 appendicitis 30.3 TNF IL1B CXCL8
11 gastric ulcer 30.3 TNF IL1B CXCL8
12 psoriasis 30.3 TNF IL6R IL4 IL1B CXCL8
13 ulcerative colitis 30.2 TNF IL4 IL1B CXCL8
14 liver cirrhosis 30.2 SERPINA3 GPT GGT1 AFP
15 peritonitis 30.2 TNF MUC16 IL4 IL1B CXCL8
16 pyelonephritis 30.1 TNF IL1B GPT CXCL8
17 clonorchiasis 30.1 TNF EPGN CXCL8 CTSF
18 sclerosing cholangitis 30.1 TNF GPT GGT1 CXCL8
19 leptospirosis 30.1 TNF IL4 IL1B CXCL8
20 stomatitis 30.1 TNF IL4 IL1B CXCL8
21 enterobiasis 30.1 IL4 EPGN
22 toxic shock syndrome 30.1 TNF IL4 IL1B CXCL8
23 candidiasis 30.1 TNF IL4 IL1B CXCL8
24 gastroesophageal reflux 30.1 TNF IL4 IL1B CXCL8
25 interstitial lung disease 30.1 TNF IL4 IL1B CXCL8
26 crohn's disease 30.0 TNF IL4 IL1B CXCL8
27 viral hepatitis 30.0 TNF SERPINA3 IL4 GPT GGT1 AFP
28 food allergy 30.0 TNF IL4 IGES CXCL8
29 amebiasis 29.9 TNF KRT9 IL4 CXCL8
30 hepatitis c 29.9 TNF GPT GGT1 AFP
31 allergic hypersensitivity disease 29.9 TNF IL4 IGES CXCL8
32 primary biliary cirrhosis 29.9 TNF IL4 IL1B GPT GGT1
33 hepatitis a 29.8 TNF IL4 GPT GGT1 AFP
34 lymphadenitis 29.8 TNF SERPINA3 IL1B CXCL8
35 gallbladder disease 29.8 SERPINA3 GPT GGT1 AFP
36 hepatitis b 29.8 TNF GPT GGT1 CXCL8 AFP
37 ascaris lumbricoides infection 29.6 SERPINA3 IL1B EPGN CXCL8
38 lung disease 29.5 TNF SERPINA3 IL4 IL1B CXCL8
39 eye disease 29.5 TNF SERPINA3 IL4 IL1B CXCL8
40 liver disease 29.0 TNF SERPINA3 IL6R IL1B GPT GGT1
41 asthma 28.7 TNF SERPINA3 IL6R IL4 IL1B IGES
42 fascioliasis 28.2 SPATA31A7 IL1B GRN GPT GGT1 EPGN
43 cholangiocarcinoma 10.8
44 intrahepatic cholangiocarcinoma 10.8
45 parenteral nutrition-associated cholestasis 10.6 GPT GGT1
46 tropical endomyocardial fibrosis 10.5 TNF IL4
47 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
48 staphylococcal toxic shock syndrome 10.5 TNF IL1B
49 angelucci's syndrome 10.5 IL1B CXCL8
50 dermatitis, atopic, 8 10.5 IL1B CXCL8

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Praziquantel

Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

40
Liver, Pancreas, Testes, Skin, Eye, Bone, Lung

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 1090)
# Title Authors PMID Year
1
[Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function]. 54 61
12886584 2003
2
[Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease]. 54 61
9026671 1996
3
AuNPs-LISA, an efficient detection assay for Opisthorchis viverrini (Ov) antigen in urine. 61
31892022 2020
4
Recent advances on the immunobiology of Bithynia spp. hosts of Opisthorchis viverrini. 61
31381930 2020
5
Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus). 61
31978047 2020
6
The New Data on the Serotonin and FMRFamide Localization in the Nervous System of Opisthorchis felineus Metacercaria. 61
32002774 2020
7
Behavior-related risk factors for opisthorchiasis-associated cholangiocarcinoma among rural people living along the mekong river in five greater mekong subregion countries. 61
31654901 2020
8
Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters. 61
31991114 2020
9
Effectiveness of Repeated Administration of Praziquantel with Disodium Glycyrrhizinate and Two Enantiomers of Praziquantel on Opisthorchis felineus (Rivolta, 1884). 61
31797191 2019
10
Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis. 61
31724067 2019
11
Inhibition of Opisthorchis felineus glutathione-dependent prostaglandin synthase by resveratrol correlates with attenuation of cholangiocyte neoplasia in a hamster model of opisthorchiasis. 61
31628937 2019
12
Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis. 61
31482789 2019
13
Opisthorchis viverrini Infection Augments the Severity of Nonalcoholic Fatty Liver Disease in High-Fat/High-Fructose Diet-Fed Hamsters. 61
31482785 2019
14
Characteristics of liver fibrosis associated with chronic Opisthorchis felineus infection in Syrian hamsters and humans. 61
31226265 2019
15
A comprehensive review of omics and host-parasite interplays studies, towards control of Opisthorchis viverrini infection for prevention of cholangiocarcinoma. 61
31100270 2019
16
Low-Grade Endemicity of Opisthorchiasis, Yangon, Myanmar. 61
31211941 2019
17
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
18
Effects of supramolecular complexation of praziquantel with disodium glycyrrhizinate on the liver fluke Opisthorchis felineus: An in vitro and in vivo study. 61
30871990 2019
19
Ecological Niche Model based on Maximum Entropy for mapping distribution of Bithynia siamensis goniomphalos, first intermediate host snail of Opisthorchis viverrini in Thailand. 61
30849302 2019
20
New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes. 61
31117933 2019
21
Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis. 61
30684449 2019
22
Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections. 61
30718244 2019
23
Comparison of stool examination techniques to detect Opisthorchis viverrini in low intensity infection. 61
30550733 2019
24
Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand. 61
30735492 2019
25
Effect of Temperature on the Killing of Opisthorchis viverrini Eggs In Vitro. 61
30840800 2019
26
Hemozoin From the Liver Fluke, Opisthorchis felineus, Modulates Dendritic Cell Responses in Bronchial Asthma Patients. 61
31750318 2019
27
Opisthorchis felineus infection provokes time-dependent accumulation of oxidative hepatobiliary lesions in the injured hamster liver. 61
31086416 2019
28
Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. 61
30644359 2019
29
Liver Flukes: Clonorchis and Opisthorchis. 61
31297762 2019
30
Evaluation of a short term effect of praziquantel treatment in opisthorchiasis-induced hepatobiliary inflammation by urinary 8-oxodG. 61
30321522 2019
31
Hypereosinophilic Syndrome, Cardiomyopathies, and Sudden Cardiac Death in Superinvasive Opisthorchiasis. 61
31210984 2019
32
Multi-disciplinary integration of networking through the RNAS+: Research on other target diseases. 61
31530397 2019
33
Preface: Sustained cooperation on research and control of neglected tropical diseases among multisectors and multipartners across borders in Southeast Asia. 61
31530398 2019
34
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts. 61
31798678 2019
35
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. 61
29649604 2019
36
A study of tribendimidine effects in vitro and in vivo on the liver fluke Opisthorchis felineus. 61
30635027 2019
37
Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis. 61
31428553 2019
38
Never seen before? Opisthorchiasis and Clonorchiasis. 61
30466135 2018
39
Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini. 61
30305716 2018
40
Identification of novel natural inhibitors of Opisthorchis felineus cytochrome P450 using structure-based screening and molecular dynamic simulation. 61
29029597 2018
41
Social defeat stress exacerbates the blood abnormalities in Opisthorchis felineus-infected mice. 61
30165039 2018
42
Human liver fluke Opisthorchis viverrini (Trematoda, Opisthorchiidae) in Central Myanmar: New records of adults and metacercariae identified by morphology and molecular analysis. 61
29772216 2018
43
Behaviour and eating habits as determinants for human opisthorchiasis in the Bolsena Lake area, Italy. 61
30348910 2018
44
Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis 61
30255697 2018
45
Contraception, opisthorchiasis, and cholangiocarcinoma. 61
30249915 2018
46
Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study. 61
30139338 2018
47
Immunochromatographic test for rapid serological diagnosis of human angiostrongyliasis. 61
29908250 2018
48
Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War. 61
30034207 2018
49
Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors. 61
30064407 2018
50
Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship. 61
30618454 2018

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 TNF IL6R IL4 IL1B CXCL8
2
Show member pathways
12.05 TNF SERPINA3 IL4 IL1B GGT1
3
Show member pathways
12.03 TNF IL4 IL1B CXCL8
4 12.01 TNF IL6R IL1B CXCL8
5 11.84 TNF IL4 IL1B CXCL8
6 11.82 IL6R IL1B CXCL8
7 11.8 TNF IL1B CXCL8
8 11.79 TNF IL1B CXCL8
9 11.77 TNF IL1B CXCL8
10 11.74 TNF IL1B CXCL8
11 11.7 TNF IL6R IL4 IL1B
12 11.67 IL4 CXCL8 AFP
13 11.66 TNF IL4 IL1B
14 11.62 TNF IL1B CXCL8
15
Show member pathways
11.61 TNF IL4 CXCL8
16
Show member pathways
11.52 TNF IL1B CXCL8
17 11.47 TNF IL1B CXCL8
18 11.41 TNF MFGE8 IL4 IL1B
19 11.4 TNF IL1B CXCL8
20 11.26 TNF IL4 IL1B CXCL8
21 11.16 TNF IL4 IL1B
22 11.08 TNF IL6R IL4 IL1B CXCL8
23 11.07 TNF IL4 IL1B
24 10.95 TNF IL4 IL1B CXCL8

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 SERPINA3 MUC16 MFGE8 KRT9 GRN GPT
2 extracellular region GO:0005576 9.7 TNF SERPINA3 MUC16 MFGE8 IL6R IL4
3 extracellular space GO:0005615 9.47 TNF SERPINA3 MUC16 MFGE8 KRT9 IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 TNF IL6R IL4
2 positive regulation of interleukin-6 production GO:0032755 9.54 TNF IL6R IL1B
3 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.49 TNF IL1B
4 positive regulation of neuroinflammatory response GO:0150078 9.48 TNF IL1B
5 positive regulation of chemokine biosynthetic process GO:0045080 9.46 TNF IL1B
6 positive regulation of phagocytosis GO:0050766 9.43 TNF MFGE8 IL1B
7 regulation of establishment of endothelial barrier GO:1903140 9.4 TNF IL1B
8 positive regulation of fever generation GO:0031622 9.32 TNF IL1B
9 sequestering of triglyceride GO:0030730 9.16 TNF IL1B
10 cytokine-mediated signaling pathway GO:0019221 9.02 TNF IL6R IL4 IL1B CXCL8
11 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 TNF IL1B

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL4 IL1B GRN CXCL8

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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