MCID: OPS001
MIFTS: 39

Opisthorchiasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Opisthorchiasis

MalaCards integrated aliases for Opisthorchiasis:

Name: Opisthorchiasis 12 53 55 44 15 73
Infection Due to Cat Liver Fluke 53
Infection Due to Opisthorchis 53
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD10 33 B66.0
ICD9CM 35 121.0
MeSH 44 D009889
SNOMED-CT 68 1059007 187124006
UMLS 73 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to clonorchiasis and fascioliasis. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways/superpathways are Regulation of IFNA signaling and Th17 cell differentiation. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 76 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 clonorchiasis 30.9 CTSF CXCL8
2 fascioliasis 30.7 GPT IL1B
3 preterm premature rupture of the membranes 10.6 CXCL8 IL6R
4 lung giant cell carcinoma 10.6 CXCL8 IL6R
5 tungiasis 10.6 CXCL8 IL4
6 papillary conjunctivitis 10.6 CXCL8 IL4
7 giant papillary conjunctivitis 10.6 CXCL8 IL4
8 atopic keratoconjunctivitis 10.5 IL4 MUC16
9 cholangiocarcinoma 10.5
10 recurrent corneal erosion 10.4 CXCL8 IL1B
11 bagassosis 10.4 CXCL8 IL1B
12 scrub typhus 10.4 GPT IL1B
13 peptic esophagitis 10.4 CXCL8 IL1B
14 funisitis 10.4 CXCL8 IL1B
15 primary peritoneal carcinoma 10.4 CXCL8 MUC16
16 allergic conjunctivitis 10.4 CXCL8 IL4
17 haemophilus influenzae 10.4 CXCL8 IL1B
18 crohn's colitis 10.4 CXCL8 IL1B
19 vaginal disease 10.4 CXCL8 IL1B
20 endometrial disease 10.4 CXCL8 IL1B
21 nasal cavity disease 10.4 CXCL8 IL4
22 diversion colitis 10.4 IL1B IL4
23 dental pulp disease 10.4 CXCL8 IL1B
24 vaginitis 10.4 CXCL8 IL1B
25 joint disorders 10.4 IL1B IL6R
26 pleurisy 10.4 CXCL8 MUC16
27 cercarial dermatitis 10.4 IL1B IL4
28 pharyngitis 10.4 CXCL8 IL1B
29 aseptic meningitis 10.4 CXCL8 IL1B
30 pulpitis 10.3 CXCL8 IL1B
31 primary amebic meningoencephalitis 10.3 IL1B IL4
32 middle ear disease 10.3 CXCL8 IL1B
33 wells syndrome 10.3 CXCL8 IL1B
34 eales disease 10.3 IL1B IL4
35 perinatal necrotizing enterocolitis 10.3 CXCL8 IL1B
36 viral encephalitis 10.3 CXCL8 IL1B
37 nose disease 10.3 CXCL8 IL4
38 aphthous stomatitis 10.3 IL1B IL4
39 prostatitis 10.3 CXCL8 IL1B
40 interstitial cystitis 10.3 CXCL8 IL4
41 extrinsic cardiomyopathy 10.3 IL1B IL4
42 acute respiratory distress syndrome 10.3 CXCL8 IL1B
43 brucellosis 10.2 CXCL8 IL4
44 bacterial vaginosis 10.2 CXCL8 IL1B
45 keratoconjunctivitis sicca 10.2 IL1B IL4
46 gastric ulcer 10.2 CXCL8 IL1B
47 leptospirosis 10.2 CXCL8 IL1B
48 somatoform disorder 10.2 IL1B IL4
49 hepatitis 10.2
50 pyelonephritis 10.1 CXCL8 IL1B

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

41
Liver, Pancreas, Testes

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 182)
# Title Authors Year
1
Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer. ( 29907253 )
2018
2
Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease. ( 29953446 )
2018
3
Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis. ( 29637887 )
2018
4
Opisthorchiasis and viral hepatitis b: clinical cases. ( 29602941 )
2018
5
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia. ( 29765958 )
2018
6
Acute Opisthorchiasis in a Kazakh Man. ( 29911767 )
2018
7
Analysis of a school-based health education model to prevent opisthorchiasis and cholangiocarcinoma in primary school children in northeast Thailand. ( 29809091 )
2018
8
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. ( 29649604 )
2018
9
Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus). ( 29088234 )
2017
10
Social network analysis of food sharing among households in opisthorchiasis endemic villages of Lawa Lake, Thailand. ( 28188767 )
2017
11
Opisthorchiasis, hypercholesterolemia, and cholangiocarcinoma: A reappraisal. ( 28413795 )
2017
12
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis. ( 28429227 )
2017
13
Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. ( 28198451 )
2017
14
Present Situation of Opisthorchiasis in Vientiane Capital, Lao Peoples' Democratic Republic. ( 28552889 )
2017
15
Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem. ( 28848361 )
2017
16
Ultrasonographic features of hepatobiliary in opisthorchiasis. ( 27956092 )
2016
17
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. ( 27576001 )
2016
18
PREVLENCE AND RISK FACTORS FOR OPISTHORCHIS VIVERRINI INFECTION AMONG CATS AND DOGS IN SIX DISTRICTS SURROUNDING THE UBOLRATANA DAM, AN ENDEMIC AREA FOR HUMAN OPISTHORCHIASIS IN NORTHEASTERN THAILAND. ( 29634175 )
2016
19
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. ( 27140305 )
2016
20
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. ( 27507639 )
2016
21
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. ( 27939972 )
2016
22
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. ( 26817235 )
2016
23
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? ( 27919744 )
2016
24
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. ( 27890720 )
2016
25
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. ( 27482325 )
2016
26
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. ( 26485024 )
2015
27
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. ( 25836376 )
2015
28
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. ( 26312563 )
2015
29
Opisthorchiasis: an overlooked danger. ( 25836334 )
2015
30
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. ( 26108023 )
2015
31
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. ( 25877389 )
2015
32
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. ( 26602874 )
2015
33
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. ( 26625799 )
2015
34
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. ( 26344868 )
2015
35
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. ( 25041016 )
2014
36
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. ( 25102053 )
2014
37
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. ( 25188119 )
2014
38
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. ( 24516289 )
2013
39
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. ( 24018821 )
2013
40
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. ( 24122204 )
2013
41
Development of a community-based approach to opisthorchiasis control. ( 24377646 )
2013
42
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. ( 23188705 )
2013
43
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. ( 24349600 )
2013
44
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. ( 23052766 )
2013
45
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. ( 23717698 )
2013
46
Does a combination of opisthorchiasis and ethyl alcohol consumption enhance early cholangiofibrosis, the risk of cholangiocarcinoma? ( 23807659 )
2013
47
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. ( 24055716 )
2013
48
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. ( 21843654 )
2012
49
Discovery of human opisthorchiasis: a mysterious history. ( 21867771 )
2012
50
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. ( 21704728 )
2012

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 CXCL8 IL1B IL4 IL6R
2
Show member pathways
12.15 IL1B IL4 IL6R
3
Show member pathways
11.9 CXCL8 IL1B IL4
4 11.88 CXCL8 IL1B IL6R
5
Show member pathways
11.79 CXCL8 IL1B IL4 IL6R
6
Show member pathways
11.77 CXCL8 IL1B IL4 IL6R
7 11.73 CXCL8 IL1B IL4
8 11.63 CXCL8 IL1B IL6R
9 11.57 IL1B IL4 IL6R
10 11.46 AFP CXCL8 IL4
11 11.25 CXCL8 IL1B
12 11.23 CXCL8 IL1B IL4
13 11.04 IL1B IL4
14 11 IL1B IL4
15 10.98 CXCL8 IL1B IL4 IL6R
16 10.82 CXCL8 IL1B IL4

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AFP CXCL8 IL1B IL4 IL6R MFGE8
2 extracellular space GO:0005615 9.28 AFP CTSF CXCL8 GPT IL1B IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phagocytosis GO:0050766 9.16 IL1B MFGE8
2 positive regulation of leukocyte chemotaxis GO:0002690 8.96 CXCL8 IL6R
3 cytokine-mediated signaling pathway GO:0019221 8.92 CXCL8 IL1B IL4 IL6R

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL4

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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