MCID: OPP001
MIFTS: 24

Opportunistic Bacterial Infectious Disease

Categories: Infectious diseases

Aliases & Classifications for Opportunistic Bacterial Infectious Disease

MalaCards integrated aliases for Opportunistic Bacterial Infectious Disease:

Name: Opportunistic Bacterial Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050340

Summaries for Opportunistic Bacterial Infectious Disease

Disease Ontology : 12 A bacterial infectious disease that results in infection by bacteria in individuals whose host defense mechanisms have been compromised.

MalaCards based summary : Opportunistic Bacterial Infectious Disease is related to nocardiosis and acinetobacter infectious disease. An important gene associated with Opportunistic Bacterial Infectious Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Opportunistic Bacterial Infectious Disease

Diseases related to Opportunistic Bacterial Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
# Related Disease Score Top Affiliating Genes
1 nocardiosis 29.9 TNF LYZ IL12RB2 IL12RB1 IFNGR2 IFNG
2 acinetobacter infectious disease 11.2
3 mycobacterium fortuitum 10.4 IL12RB1 HSPD1
4 coccidioidomycosis 10.3 IL12RB1 CD4
5 autoimmune atherosclerosis 10.3 HSPD1 CD4
6 bacillary angiomatosis 10.3 HSPD1 CD4
7 chancroid 10.3 HSPD1 CD4
8 glanders 10.3 HSPD1 CD4
9 endemic typhus 10.3 HSPD1 CRP
10 basidiobolomycosis 10.3 HSPD1 CRP
11 epidural abscess 10.3 CRP CD4
12 primary syphilis 10.3 CRP CD4
13 urogenital tuberculosis 10.3 CRP CD4
14 breast abscess 10.3 CRP CD4
15 pyomyositis 10.3 CRP CD4
16 splenic abscess 10.3 CRP CD4
17 orbital cellulitis 10.3 CRP CD4
18 acute orbital inflammation 10.3 CRP CD4
19 neuroretinitis 10.3 CRP CD4
20 mediastinitis 10.3 CRP CD4
21 optic papillitis 10.3 CRP CD4
22 mikulicz disease 10.3 CRP CD4
23 secondary syphilis 10.3 CRP CD4
24 external ear disease 10.3 CRP CD4
25 otitis externa 10.3 CRP CD4
26 lymphangitis 10.3 CRP CD4
27 splenic tuberculosis 10.3 CRP CD4
28 parotid disease 10.3 CRP CD4
29 adiaspiromycosis 10.3 HSPD1 CD4
30 pleural empyema 10.3 CRP CD4
31 immunodeficiency 28 10.3 IL12RB1 IFNGR2
32 kwashiorkor 10.3 CRP CD4
33 cranial nerve palsy 10.3 CRP CD4
34 polyclonal hypergammaglobulinemia 10.3 CRP CD4
35 suppurative thyroiditis 10.3 CRP CD4
36 chronic meningitis 10.2 CRP CD4
37 tick infestation 10.2 HSPD1 CD4
38 parotitis 10.2 CRP CD4
39 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.2 HSPD1 CD4
40 type 1 diabetes mellitus 23 10.2 TNF CD4
41 drug reaction with eosinophilia and systemic symptoms 10.2 TNF CRP
42 xerophthalmia 10.2 CRP CD4
43 anterior scleritis 10.2 TNF CRP
44 posterior scleritis 10.2 TNF CRP
45 tuberculous epididymitis 10.2 TNF CRP
46 granuloma annulare 10.2 TNF CD4
47 dermatophytosis 10.2 IL12RB1 CD4
48 orbital disease 10.2 CRP CD4
49 hyper ige recurrent infection syndrome 1 10.2 IL12RB1 CD4
50 central nervous system tuberculosis 10.2 TNF CD4

Graphical network of the top 20 diseases related to Opportunistic Bacterial Infectious Disease:



Diseases related to Opportunistic Bacterial Infectious Disease

Symptoms & Phenotypes for Opportunistic Bacterial Infectious Disease

MGI Mouse Phenotypes related to Opportunistic Bacterial Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CD4 HSPD1 IFNG IFNGR2 IL12RB1 IL12RB2
2 homeostasis/metabolism MP:0005376 9.85 CD4 CRP IFNG IFNGR2 IL12RB1 IL12RB2
3 digestive/alimentary MP:0005381 9.8 CD4 IFNG IL12RB2 LYZ RPH3AL TNF
4 immune system MP:0005387 9.61 CD4 CRP IFNG IFNGR2 IL12RB1 IL12RB2
5 neoplasm MP:0002006 9.02 IFNG IL12RB2 IRF8 LYZ TNF

Drugs & Therapeutics for Opportunistic Bacterial Infectious Disease

Search Clinical Trials , NIH Clinical Center for Opportunistic Bacterial Infectious Disease

Genetic Tests for Opportunistic Bacterial Infectious Disease

Anatomical Context for Opportunistic Bacterial Infectious Disease

Publications for Opportunistic Bacterial Infectious Disease

Variations for Opportunistic Bacterial Infectious Disease

Expression for Opportunistic Bacterial Infectious Disease

Search GEO for disease gene expression data for Opportunistic Bacterial Infectious Disease.

Pathways for Opportunistic Bacterial Infectious Disease

Pathways related to Opportunistic Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 TNF LYZ IRF8 IL12RB2 IL12RB1 IFNGR2
2
Show member pathways
13.32 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
3
Show member pathways
13.06 TNF IRF8 IL12RB2 IL12RB1 IFNGR2 IFNG
4
Show member pathways
12.67 TNF IFNG HSPD1 CD4
5 12.66 IL12RB2 IL12RB1 IFNGR2 IFNG
6
Show member pathways
12.42 TNF IFNGR2 IFNG CD4
7
Show member pathways
12.4 TNF IL12RB1 IFNG CD4
8
Show member pathways
12.29 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
9
Show member pathways
12.25 IL12RB2 IL12RB1 IFNGR2 IFNG
10
Show member pathways
12.17 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
11 12.05 TNF IFNGR2 IFNG HSPD1
12
Show member pathways
12.03 TNF IFNGR2 IFNG
13 12.01 TNF IFNGR2 IFNG
14
Show member pathways
12 TNF IFNGR2 IFNG
15 11.87 TNF IFNGR2 IFNG
16 11.82 TNF IFNG CD4
17
Show member pathways
11.72 IL12RB2 IL12RB1 IFNG CD4
18
Show member pathways
11.69 IL12RB1 IFNG CD4
19 11.49 TNF IRF8 IFNG CD4
20
Show member pathways
11.41 TNF IFNGR2 IFNG
21 11.35 IL12RB2 IFNG CD4
22 11.26 TNF IL12RB2 IL12RB1 IFNG CD4
23 11.22 IRF8 IFNGR2 IFNG
24
Show member pathways
11.1 IL12RB2 IL12RB1 IFNG
25 11.07 TNF IFNG CD4
26
Show member pathways
10.98 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
27 10.88 TNF CRP

GO Terms for Opportunistic Bacterial Infectious Disease

Cellular components related to Opportunistic Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 TNF IL12RB2 IL12RB1 CD4

Biological processes related to Opportunistic Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 TNF IRF8 IFNG CD4
2 cell surface receptor signaling pathway GO:0007166 9.81 IL12RB2 IFNGR2 IFNG CD4
3 response to virus GO:0009615 9.75 TNF IFNGR2 IFNG
4 defense response to Gram-positive bacterium GO:0050830 9.73 TNF LYZ CRP
5 positive regulation of inflammatory response GO:0050729 9.71 TNF IFNG HSPD1
6 positive regulation of interleukin-6 production GO:0032755 9.7 TNF IFNG HSPD1
7 interferon-gamma-mediated signaling pathway GO:0060333 9.63 IRF8 IFNGR2 IFNG
8 positive regulation of T cell activation GO:0050870 9.62 HSPD1 CD4
9 positive regulation of osteoclast differentiation GO:0045672 9.62 TNF IFNG
10 macrophage differentiation GO:0030225 9.61 IFNG CD4
11 interleukin-12-mediated signaling pathway GO:0035722 9.61 IL12RB2 IL12RB1 IFNG
12 positive regulation of amyloid-beta formation GO:1902004 9.6 TNF IFNG
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 TNF IFNG
14 astrocyte activation GO:0048143 9.58 TNF IFNG
15 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.57 IFNGR2 IFNG
16 negative regulation of amyloid-beta clearance GO:1900222 9.55 TNF IFNG
17 positive regulation of interleukin-12 production GO:0032735 9.54 IRF8 IFNG HSPD1
18 negative regulation of lipid storage GO:0010888 9.49 TNF CRP
19 positive regulation of NMDA glutamate receptor activity GO:1904783 9.48 IFNGR2 IFNG
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IFNG
21 cytokine-mediated signaling pathway GO:0019221 9.35 TNF IL12RB2 IL12RB1 IFNGR2 CD4
22 microglial cell activation GO:0001774 9.33 TNF IFNGR2 IFNG
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
24 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
25 positive regulation of interferon-gamma production GO:0032729 9.02 TNF IRF8 IL12RB2 IL12RB1 HSPD1

Molecular functions related to Opportunistic Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.8 IL12RB2 IL12RB1 IFNGR2

Sources for Opportunistic Bacterial Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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