MCID: OPP002
MIFTS: 41

Opportunistic Mycosis

Categories: Infectious diseases

Aliases & Classifications for Opportunistic Mycosis

MalaCards integrated aliases for Opportunistic Mycosis:

Name: Opportunistic Mycosis 12 15 70
Opportunistic Mycoses 12 32
Opportunistic Systemic Mycoses 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2473
ICD9CM 34 118
SNOMED-CT 67 78999002
ICD10 32 B48.7
UMLS 70 C0029119

Summaries for Opportunistic Mycosis

Disease Ontology : 12 A systemic mycosis that results in fungal infection located in human body of immunocompromised individuals, has material basis in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

MalaCards based summary : Opportunistic Mycosis, also known as opportunistic mycoses, is related to penicilliosis and trichosporonosis. An important gene associated with Opportunistic Mycosis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include human body of immunocompromised individuals, bone and lung, and related phenotypes are hematopoietic system and immune system

Related Diseases for Opportunistic Mycosis

Diseases related to Opportunistic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 647)
# Related Disease Score Top Affiliating Genes
1 penicilliosis 32.5 CLEC7A CD4 CARD9
2 trichosporonosis 32.4 CLEC7A CLEC6A CARD9
3 geotrichosis 32.4 STAT1 CD4
4 mucormycosis 32.3 CYP51A1 CLEC7A CLEC6A CD4 CCR6 CARD9
5 aspergillosis 32.0 TNF TLR2 IL6 IL4 IL10 CLEC7A
6 pneumocystosis 32.0 TNF IL6 CLEC7A CLEC4E CD8A CD4
7 cryptococcosis 31.9 TNF IL4 IL17A IL10 CLEC7A CLEC6A
8 candidiasis 31.4 TNF TLR2 STAT1 SKAP2 IL6 IL4
9 pleural disease 30.5 TNF IL6 CD8A CD4 CCR6
10 phaeohyphomycosis 30.5 CYP51A1 CLEC7A CLEC6A CLEC4E CARD9
11 acquired immunodeficiency syndrome 30.5 TNF IL6 IL10 CD4 CCR6
12 histoplasmosis 30.5 TNF STAT1 CLEC7A CD8A CD4 CCR6
13 pulmonary tuberculosis 30.4 TNF TLR2 IL6 IL4 IL10
14 chorioretinitis 30.4 TNF IL6 IL17A IL10 CD8A CD4
15 fungal infectious disease 30.2 TNF TLR2 STAT1 SKAP2 IL6 IL4
16 oral candidiasis 30.1 STAT1 SKAP2 IL17RA IL17A CLEC7A CLEC6A
17 skin disease 30.0 TNF TLR2 IL6 IL4 IL17A IL10
18 immune deficiency disease 29.8 TNF TLR2 STAT1 IL6 IL4 IL17A
19 nail disease 29.7 TNF STAT1 IL6 IL17RA IL17F IL17A
20 chronic mucocutaneous candidiasis 29.4 TNF TLR2 STAT1 IL6 IL4 IL17RA
21 fusariosis 11.1
22 microsporidiosis 11.1
23 maple bark strippers' lung 11.1
24 cork-handlers' disease 10.5 CD8A CD4
25 necrotic uveal melanoma 10.5 CD8A CD4
26 punctate inner choroidopathy 10.5 TNF IL10
27 early yaws 10.5 CD8A CD4
28 neonatal candidiasis 10.5 CLEC7A CLEC6A CARD9
29 external pathological resorption 10.5 TNF IL6
30 norwegian scabies 10.5 IL17A CD8A CD4
31 scabies 10.5 IL10 CD4 CCR6
32 dermatomycosis 10.5 CYP51A1 CLEC7A CD4
33 elephantiasis 10.5 IL4 IL10 CD4
34 ventilation pneumonitis 10.5 CD8A CD4
35 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
36 scorpion envenomation 10.5 TNF IL6
37 physiological polycythemia 10.5 TNF IL6
38 skin sarcoidosis 10.5 TNF CD8A CD4
39 oral tuberculosis 10.5 TNF CD8A CD4
40 t-cell adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
41 cerebritis 10.5 TNF CD8A CD4
42 granulomatous hepatitis 10.5 TNF CD8A CD4
43 adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
44 alopecia universalis congenita 10.5 CD8A CD4 AIRE
45 anogenital venereal wart 10.5 CD8A CD4 CCR6
46 pustulosis of palm and sole 10.5 TNF IL17A CCR6
47 viral exanthem 10.5 TNF CD8A CD4
48 neuroaspergillosis 10.5 CYP51A1 CLEC7A CARD9
49 tinea cruris 10.5 CYP51A1 CLEC6A CARD9
50 granulomatous dermatitis 10.5 TNF CD8A CD4

Graphical network of the top 20 diseases related to Opportunistic Mycosis:



Diseases related to Opportunistic Mycosis

Symptoms & Phenotypes for Opportunistic Mycosis

MGI Mouse Phenotypes related to Opportunistic Mycosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.41 AIRE CARD9 CCR6 CD4 CD8A CLEC4E
2 immune system MP:0005387 10.38 AIRE CARD9 CCR6 CD4 CD8A CLEC4E
3 homeostasis/metabolism MP:0005376 10.31 AIRE CARD9 CCR6 CD4 CLEC4E CLEC7A
4 digestive/alimentary MP:0005381 10.27 AIRE CD4 CLEC7A CYP51A1 IL10 IL17A
5 mortality/aging MP:0010768 10.22 AIRE CD4 CD8A CLEC4E CLEC6A CLEC7A
6 endocrine/exocrine gland MP:0005379 10.18 AIRE CD4 CD8A IL10 IL17A IL4
7 integument MP:0010771 10.07 CD4 CD8A IL10 IL17A IL17RA IL4
8 no phenotypic analysis MP:0003012 9.85 AIRE CD4 CLEC4E CLEC6A CYP51A1 IL10
9 neoplasm MP:0002006 9.8 AIRE IL10 IL17RA IL6 STAT1 TLR2
10 normal MP:0002873 9.61 AIRE CCR6 CD4 CD8A IL10 IL17F
11 respiratory system MP:0005388 9.36 AIRE CLEC7A IL10 IL17A IL17F IL17RA

Drugs & Therapeutics for Opportunistic Mycosis

Search Clinical Trials , NIH Clinical Center for Opportunistic Mycosis

Genetic Tests for Opportunistic Mycosis

Anatomical Context for Opportunistic Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Opportunistic Mycosis:

19
Human Body Of Immunocompromised Individuals

MalaCards organs/tissues related to Opportunistic Mycosis:

40
Bone, Lung, Skin, Eye, Thymus, Liver, Kidney

Publications for Opportunistic Mycosis

Articles related to Opportunistic Mycosis:

(show top 50) (show all 198)
# Title Authors PMID Year
1
Inhibition of Phospholipase by Orlistat as an Alternate Therapy to Combat Opportunistic Mycosis Caused by C. albicans. 61
33811506 2021
2
Knowledge gaps in candidaemia/invasive candidiasis in haematological cancer patients. 61
33150364 2021
3
Cryptococcosis in HIV-AIDS patients from Southern Brazil: Still a major problem. 61
33046394 2020
4
OPPORTUNITIES AND PROSPECTS OF MICROBIOLOGICAL DIAGNOSIS OF ENT ORGANS MYCOSES (REVIEW). 61
33395638 2020
5
Coumarins: antifungal effectiveness and future therapeutic scope. 61
31520360 2020
6
In vitro activity of immunosuppressive agents against Cryptococcus neoformans. 61
33160707 2020
7
Mucormycosis with cutaneous involvement. A retrospective study of 115 cases at a tertiary care hospital in Mexico. 61
33222179 2020
8
Potential missed opportunities for diagnosis of cryptococcosis and the association with mortality: A cohort study. 61
33205031 2020
9
Antifungal efficacy of atorvastatin-containing emulgel in the treatment of oral and vulvovaginal candidiasis. 61
32823281 2020
10
[Hepatolienal candidosis as a rare differential diagnosis of disseminated small parenchym lesions]. 61
32615606 2020
11
Vultures from different trophic guilds show distinct oral pathogenic yeast signatures and co-occurrence networks. 61
32224410 2020
12
Optimum Inhibition of Amphotericin-B-Resistant Candida albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids. 61
32098224 2020
13
Multiresistent opportunistic talaromycosis in a patient with ovarian cancer. 61
33685197 2020
14
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. 61
31356603 2019
15
Isolation of Cryptococcus species from the external environments of hospital and academic areas. 61
32058990 2019
16
Fungal immunology in clinical practice: Magical realism or practical reality? 61
31292656 2019
17
Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients. 61
31107543 2019
18
In vitro virulence determinants, comparative pathogenicity of Diutina (Candida) mesorugosa clinical isolates and literature review of the D. rugosa complex. 61
30985256 2019
19
ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients. 61
30843968 2019
20
Opportunistic Fungal Infections in Small Animals. 61
30272479 2018
21
[Epidemiology of invasive mycoses: A landscape in continuous change]. 61
30466999 2018
22
Opportunistic fungal infection in children and management. 61
29771758 2018
23
Clinico-mycological analysis and antifungal resistance pattern in human immunodeficiency virus-associated candidiasis: An Indian perspective. 61
30623182 2018
24
First isolation and molecular characterization of Cryptococcus neoformans var. grubii in excreta of birds in the urban perimeter of the Municipality of Popayán, Colombia. 61
30274952 2018
25
Genotypic Diversity Is Independent of Pathogenicity in Colombian Strains of Cryptococcus neoformans and Cryptococcus gattii in Galleria mellonella. 61
29976849 2018
26
Iatrogenic immunosuppression may favour Alternaria skin lesion flares. 61
29739763 2018
27
Fungal infections in animals: a patchwork of different situations. 61
29538732 2018
28
Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts. 61
29237128 2018
29
Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction. 61
29330691 2018
30
Inner Leaf Gel of Aloe striata Induces Adhesion-Reducing Morphological Hyphal Aberrations. 61
29419783 2018
31
[Opportunistic mycoses of ENT organs. Part 1]. 61
30721191 2018
32
Diagnosis of Invasive Candidiasis: From Gold Standard Methods to Promising Leading-edge Technologies. 61
30360714 2018
33
Antifungal mechanism of [RuIII(NH3)4catechol]+ complex on fluconazole-resistant Candida tropicalis. 61
28402525 2017
34
Pulmonary aspergillosis as opportunistic mycoses in a cohort of human immunodeficiency virus-infected patients: Report from a tertiary care hospital in North India. 61
28539863 2017
35
Fungal Opportunistic Pneumonias in HIV/AIDS Patients: An Indian Tertiary Care Experience. 61
28384860 2017
36
Food safety in scavenger conservation: Diet-associated exposure to livestock pharmaceuticals and opportunist mycoses in threatened Cinereous and Egyptian vultures. 61
27750097 2017
37
Complications of invasive mycoses in organ transplant recipients. 61
27690694 2016
38
Sandpits as a reservoir of potentially pathogenic fungi for children. 61
28030920 2016
39
Cryptococcosis in non-HIV/non-transplant patients: A Brazilian case series. 61
27118805 2016
40
Antifungal susceptibilities of Candida species isolated from urine culture. 61
27452427 2016
41
Cryptococcosis. 61
26897067 2016
42
Disseminated Cryptococcal Infection Resulting in Acute Respiratory Distress Syndrome (ARDS) as the Initial Clinical Presentation of AIDS. 61
27086819 2016
43
Epidemiological Characterization of Opportunistic Mycoses between the Years 2006 and 2010 in Korea. 61
26403821 2016
44
INCIDENCE DENSITY, PROPORTIONATE MORTALITY, AND RISK FACTORS OF ASPERGILLOSIS IN MAGELLANIC PENGUINS IN A REHABILITATION CENTER FROM BRAZIL. 61
26667521 2015
45
Updates on Aspergillus, Pneumocystis and other opportunistic pulmonary mycoses. 61
25982207 2015
46
Inhibitory activity of isoniazid and ethionamide against Cryptococcus biofilms. 61
26362025 2015
47
HIV/AIDS-Associated Cryptococcosis in Portugal Spanning the Pre- to Post-HAART Era: A Retrospective Assessment at the Genotypic Level Based on URA5-RFLP. 61
26169111 2015
48
Activity of Polyphenolic Compounds against Candida glabrata. 61
26426003 2015
49
Phaeohyphomycosis Caused by a Novel Species, Pseudochaetosphaeronema martinelli. 61
26135866 2015
50
Angioinvasive opportunistic filamentous mycoses in immunocompromised patients. 61
26295849 2015

Variations for Opportunistic Mycosis

Expression for Opportunistic Mycosis

Search GEO for disease gene expression data for Opportunistic Mycosis.

Pathways for Opportunistic Mycosis

Pathways related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TNF TLR2 STAT1 IL6 IL4 IL17RA
2
Show member pathways
13.82 TNF STAT1 IL6 IL4 IL17RA IL17A
3
Show member pathways
13.68 TNF IL6 IL4 IL17RA IL17F IL17A
4
Show member pathways
13.44 TNF TLR2 STAT1 IL6 IL4 IL17RA
5
Show member pathways
13.39 TNF STAT1 IL6 IL4 IL17RA IL17F
6
Show member pathways
13.32 TNF IL6 IL4 IL17RA IL17A IL10
7
Show member pathways
12.92 TNF STAT1 IL6 IL4 IL17A IL10
8 12.8 TNF TLR2 STAT1 IL6 CARD9
9
Show member pathways
12.65 TNF STAT1 IL6 IL17F IL17A IL10
10 12.65 TNF TLR2 STAT1 IL4 IL17A IL10
11
Show member pathways
12.64 TNF IL4 IL10 ICOSLG CD4
12
Show member pathways
12.63 TNF TLR2 STAT1 IL6 IL4 IL17A
13
Show member pathways
12.6 TNF TLR2 STAT1 IL6 IL4 IL17F
14
Show member pathways
12.43 TNF TLR2 IL6 IL4 IL17RA IL17F
15
Show member pathways
12.4 STAT1 IL6 IL4 IL10
16
Show member pathways
12.33 TNF IL6 IL10 CCR6
17
Show member pathways
12.31 TNF TLR2 STAT1 IL4 IL10
18
Show member pathways
12.31 TNF STAT1 IL6 IL4 IL17A IL10
19 12.24 TNF STAT1 IL6 CARD9
20
Show member pathways
12.23 TNF TLR2 STAT1 IL6 IL4
21 12.23 TNF TLR2 STAT1 IL6 IL10 CLEC7A
22
Show member pathways
12.22 TNF TLR2 STAT1 IL6
23 12.19 TNF TLR2 STAT1 IL6
24 12.18 TNF SKAP2 IL6 IL10 CD8A CD4
25
Show member pathways
12.16 TNF STAT1 IL6 IL10 CLEC7A CLEC6A
26 12.1 TNF IL6 IL4 IL10 CD8A CD4
27 12.06 TNF STAT1 IL6 IL4 IL17F IL17A
28
Show member pathways
12.01 STAT1 IL4 CD8A CD4
29 11.98 TNF IL6 IL4 CD8A CD4
30 11.96 TNF TLR2 IL6 IL10
31 11.91 TNF TLR2 IL6 IL17A
32
Show member pathways
11.91 IL6 IL17RA IL17F IL17A
33 11.84 TNF IL6 IL17RA IL10 CD8A CD4
34 11.79 STAT1 IL6 IL4
35 11.75 TNF IL6 IL10
36 11.7 TNF IL4 IL17A IL10 CD8A CD4
37 11.67 TNF IL6 IL4
38 11.62 TNF TLR2 IL6
39 11.61 TNF TLR2 IL6 IL10
40 11.6 TNF IL6 IL4 IL10
41
Show member pathways
11.58 TNF TLR2 STAT1 IL6 IL17A IL10
42 11.51 IL4 IL10 CD4
43 11.42 CD8A CD4 AIRE
44 11.41 TNF IL6 IL10
45 11.39 TNF IL6 IL4 IL17A
46 11.38 TNF IL6 IL10
47 11.37 TNF IL6 IL4 IL10 CD4
48 11.32 TNF TLR2 IL6 IL4 IL10 ICOSLG
49
Show member pathways
11.18 TLR2 STAT1 IL6 IL4 IL17RA IL17F

GO Terms for Opportunistic Mycosis

Cellular components related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF IL17A ICOSLG CD8A CD4 CCR6

Biological processes related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.31 TLR2 STAT1 SKAP2 IL6 IL4 IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.2 TNF TLR2 STAT1 IL6 IL4 IL17F
3 positive regulation of transcription, DNA-templated GO:0045893 10.14 TNF STAT1 IL6 IL4 IL10 CD4
4 positive regulation of gene expression GO:0010628 10.1 TNF TLR2 IL6 IL4 CLEC7A
5 innate immune response GO:0045087 10.08 TLR2 IL17RA IL17F IL17A CLEC7A CLEC6A
6 adaptive immune response GO:0002250 10.07 IL17RA IL17F IL17A ICOSLG CLEC6A CD8A
7 inflammatory response GO:0006954 10.04 TNF TLR2 IL6 IL17RA IL17F IL17A
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF CLEC6A CD4 CARD9
9 cytokine-mediated signaling pathway GO:0019221 9.92 TNF STAT1 IL6 IL4 IL17F IL17A
10 immune system process GO:0002376 9.9 TLR2 IL17RA IL17F IL17A ICOSLG CLEC7A
11 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 IL17F IL17A CD4
12 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR2 IL6 CLEC7A
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 TNF IL6 IL4
14 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
15 humoral immune response GO:0006959 9.87 TNF IL6 CCR6 AIRE
16 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL4 CD4
17 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A CLEC7A
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF STAT1 IL6
19 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 CLEC6A
20 defense response to Gram-positive bacterium GO:0050830 9.85 TNF TLR2 IL6 IL17F IL17A CARD9
21 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.83 TNF CLEC7A CARD9
22 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR2 IL6 IL17A CLEC7A CARD9
23 positive regulation of interleukin-12 production GO:0032735 9.81 TLR2 IL17A CLEC7A
24 positive regulation of chemokine production GO:0032722 9.81 TNF TLR2 IL6
25 positive regulation of interleukin-10 production GO:0032733 9.81 TLR2 IL6 IL4 CLEC7A
26 B cell activation GO:0042113 9.8 SKAP2 IL4 ICOSLG
27 T cell activation GO:0042110 9.8 IL4 ICOSLG CLEC7A CD8A CD4
28 positive regulation of JAK-STAT cascade GO:0046427 9.79 TNF IL6 IL10
29 microglial cell activation GO:0001774 9.79 TNF TLR2 IL4
30 interleukin-17-mediated signaling pathway GO:0097400 9.71 IL17RA IL17F IL17A
31 negative regulation of amyloid-beta clearance GO:1900222 9.7 TNF CYP51A1
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 IL4 IL10
33 response to molecule of bacterial origin GO:0002237 9.7 TLR2 IL10
34 negative regulation of lipid storage GO:0010888 9.69 TNF IL6
35 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
36 response to peptidoglycan GO:0032494 9.68 IL6 CARD9
37 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
38 positive regulation of mononuclear cell migration GO:0071677 9.67 TNF IL4
39 negative regulation of cytokine production involved in immune response GO:0002719 9.66 TNF IL10
40 type 2 immune response GO:0042092 9.65 IL4 IL10
41 positive regulation of interleukin-23 production GO:0032747 9.65 IL17RA IL17A
42 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 TNF IL6 IL17F IL17A CLEC7A
43 immune response GO:0006955 9.65 TNF TLR2 IL6 IL4 IL17A IL10
44 fibroblast activation GO:0072537 9.64 IL17RA IL17A
45 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.63 IL17RA IL17F IL17A
46 regulation of isotype switching GO:0045191 9.62 IL4 IL10
47 regulation of interleukin-2 production GO:0032663 9.61 IL17F CARD9
48 positive regulation of antimicrobial peptide production GO:0002225 9.6 IL17F IL17A
49 positive regulation of interleukin-6 production GO:0032755 9.23 TNF TLR2 IL6 IL17RA IL17F IL17A

Molecular functions related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pattern recognition receptor activity GO:0038187 9.13 TLR2 CLEC7A CLEC4E
2 cytokine activity GO:0005125 9.1 TNF IL6 IL4 IL17F IL17A IL10

Sources for Opportunistic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....