MCID: OPP002
MIFTS: 36

Opportunistic Mycosis

Categories: Infectious diseases

Aliases & Classifications for Opportunistic Mycosis

MalaCards integrated aliases for Opportunistic Mycosis:

Name: Opportunistic Mycosis 12 15 73
Opportunistic Systemic Mycoses 12
Opportunistic Mycoses 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2473
ICD9CM 35 118
SNOMED-CT 68 187108005 78999002
ICD10 33 B48.7
UMLS 73 C0029119

Summaries for Opportunistic Mycosis

Disease Ontology : 12 A systemic mycosis that results in fungal infection located in human body of immunocompromised individuals, has material basis in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

MalaCards based summary : Opportunistic Mycosis, also known as opportunistic systemic mycoses, is related to trichosporonosis and pneumocystosis. An important gene associated with Opportunistic Mycosis is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include human body of immunocompromised individuals, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Opportunistic Mycosis

Diseases related to Opportunistic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 trichosporonosis 32.5 IFNG IL17A TNF
2 pneumocystosis 31.7 CD40LG CD79A CLEC7A FLNC TNF
3 cryptococcosis 31.7 CARD9 IFNG IL4 PLB1 TLR9
4 aspergillosis 31.0 CD79A CLEC7A IFNG IL10 IL4 TLR9
5 candidiasis 27.2 AIRE CARD9 CD79A CDR1 CLEC7A IFNG
6 penicilliosis 11.0
7 fusariosis 11.0
8 geotrichosis 11.0
9 microsporidiosis 11.0
10 maple bark strippers' lung 11.0
11 cutaneous mycosis 10.9 CARD9 CLEC7A FLNC
12 tinea capitis 10.9 CARD9 FLNC ST5
13 selective igg deficiency disease 10.9 CD40LG CD79A
14 c1q nephropathy 10.9 CD40LG CD79A
15 meningovascular neurosyphilis 10.8 CD40LG CD79A
16 alpha chain disease 10.8 CD40LG CD79A
17 neuroschistosomiasis 10.8 CD79A IFNG
18 brill-zinsser disease 10.8 CD40LG CD79A
19 exudative glomerulonephritis 10.8 CD40LG CD79A
20 cork-handlers' disease 10.8 CD40LG CD79A
21 salpingo-oophoritis 10.8 CD40LG CD79A
22 myositis fibrosa 10.8 IFNG IL17A TLR9
23 early yaws 10.8 CD40LG CD79A
24 ventilation pneumonitis 10.8 CD40LG CD79A
25 chronic interstitial cystitis 10.8 CD40LG CD79A
26 cryofibrinogenemia 10.8 CD40LG CD79A
27 trichostrongyloidiasis 10.7 CD40LG CD79A
28 subacute bacterial endocarditis 10.7 CD40LG CD79A
29 heterophyiasis 10.7 CD40LG CD79A
30 mycoplasmal pneumonia 10.7 IFNG IL4
31 immunoglobulin g deficiency 10.7 CD40LG CD79A
32 zika fever 10.7 CD40LG STAT1
33 orbital granuloma 10.7 CD40LG CD79A
34 transient hypogammaglobulinemia of infancy 10.7 CD40LG CD79A
35 autoimmune disease of urogenital tract 10.7 CD40LG CD79A TLR9
36 nail disorder, nonsyndromic congenital, 1 10.7 AIRE CD79A
37 punctate inner choroidopathy 10.7 IL10 TNF
38 asymptomatic neurosyphilis 10.7 CD40LG CD79A IL17A
39 campylobacteriosis 10.7 IFNG ST5 STAT1
40 hyperglobulinemic purpura 10.7 CD40LG CD79A
41 chronic inflammatory demyelinating polyradiculoneuropathy 10.7 IFNG IL17A STAT1
42 ross river fever 10.7 CD40LG IL10
43 langerhans cell histiocytosis 10.7 CD101 IFNG IL17A
44 gastroduodenitis 10.7 CD40LG CD79A
45 mature b-cell neoplasm 10.7 CD40LG CD79A TLR9
46 b cell deficiency 10.7 CD40LG CD79A TLR9
47 bacterial conjunctivitis 10.7 CD40LG CD79A
48 immunodeficiency 17 10.6 CARD9 CD40LG STAT1
49 familial candidiasis 10.6 CARD9 IL17RA
50 chromoblastomycosis 10.6 CARD9 CLEC7A IL4

Graphical network of the top 20 diseases related to Opportunistic Mycosis:



Diseases related to Opportunistic Mycosis

Symptoms & Phenotypes for Opportunistic Mycosis

GenomeRNAi Phenotypes related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD40LG IL10 IL17A PLB1 STAT1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CARD9 CD40LG IL10 IL17A PLB1 STAT1

MGI Mouse Phenotypes related to Opportunistic Mycosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 TNF IL4 SKAP2 STAT1 IL17A IL17RA
2 homeostasis/metabolism MP:0005376 10.31 TNF IL4 IL10 STAT1 IL17A IL17RA
3 immune system MP:0005387 10.28 TNF IL4 SKAP2 STAT1 IL17A IL17RA
4 digestive/alimentary MP:0005381 10.19 TNF IL4 IL10 STAT1 IL17A TLR9
5 endocrine/exocrine gland MP:0005379 10.13 IL4 IL10 STAT1 IL17A TNF IFNG
6 mortality/aging MP:0010768 10.07 TLR9 IL4 IL10 SKAP2 STAT1 IL17A
7 integument MP:0010771 9.97 IL17RA IL4 IL10 STAT1 TNF IFNG
8 liver/biliary system MP:0005370 9.87 IL4 IL10 STAT1 TNF IFNG CD79A
9 neoplasm MP:0002006 9.7 IL17RA IL10 STAT1 TNF CD79A AIRE
10 no phenotypic analysis MP:0003012 9.56 TNF IL4 IL10 IL17A IL17RA CD79A
11 respiratory system MP:0005388 9.32 TNF IL4 IL17A IL17RA IL10 CLEC7A

Drugs & Therapeutics for Opportunistic Mycosis

Search Clinical Trials , NIH Clinical Center for Opportunistic Mycosis

Genetic Tests for Opportunistic Mycosis

Anatomical Context for Opportunistic Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Opportunistic Mycosis:

19
Human Body Of Immunocompromised Individuals

Publications for Opportunistic Mycosis

Articles related to Opportunistic Mycosis:

# Title Authors Year
1
Experimental Trichosporon infection in persistently granulocytopenic rabbits: implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis. ( 1535092 )
1992

Variations for Opportunistic Mycosis

Expression for Opportunistic Mycosis

Search GEO for disease gene expression data for Opportunistic Mycosis.

Pathways for Opportunistic Mycosis

Pathways related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CARD9 CD101 CD40LG CD79A CLEC7A IFNG
2
Show member pathways
13.38 CD40LG IL10 IL17A IL17RA IL4 STAT1
3
Show member pathways
13.33 CD40LG IFNG IL10 IL17A IL17RA IL4
4
Show member pathways
13.28 CD40LG FLNC IL10 IL17A IL17RA IL4
5
Show member pathways
12.99 CARD9 IFNG IL10 STAT1 TLR9 TNF
6
Show member pathways
12.87 CD40LG IFNG IL10 IL17A IL4 STAT1
7
Show member pathways
12.76 CD79A IFNG IL4 TLR9 TNF
8
Show member pathways
12.76 IFNG IL4 STAT1 TLR9 TNF
9
Show member pathways
12.63 IFNG IL10 IL17A IL4 STAT1 TNF
10
Show member pathways
12.56 IFNG IL10 IL17A STAT1 TNF
11
Show member pathways
12.45 IFNG IL10 IL17A IL4 STAT1 TNF
12
Show member pathways
12.42 CD40LG IFNG IL10 IL17A IL4 TNF
13
Show member pathways
12.32 IFNG IL17A IL17RA IL4 TNF
14
Show member pathways
12.18 IFNG IL4 STAT1 TLR9 TNF
15
Show member pathways
12.18 IFNG IL10 IL17A STAT1 TLR9 TNF
16 12.17 IFNG STAT1 TLR9 TNF
17
Show member pathways
12.15 CD40LG IFNG IL10 IL4 STAT1 TNF
18
Show member pathways
12.08 CARD9 CLEC7A IL10 STAT1 TLR9 TNF
19
Show member pathways
12.06 IFNG IL10 IL17A IL4 STAT1
20 11.99 CD79A IFNG IL10 IL4 TNF
21 11.97 IL10 IL17A IL4 STAT1 TNF
22 11.95 CARD9 CLEC7A IFNG IL10 STAT1 TLR9
23 11.84 IFNG IL10 TNF
24 11.84 CARD9 CD40LG CD79A IFNG IL10 IL17A
25 11.81 IFNG IL17A TNF
26 11.77 IFNG IL4 STAT1
27
Show member pathways
11.76 CD40LG IFNG IL4 TNF
28 11.64 CD40LG IL10 IL4
29
Show member pathways
11.64 CD40LG IFNG TNF
30 11.59 IFNG STAT1 TNF
31 11.59 IFNG IL10 IL17RA TLR9 TNF
32 11.51 IL10 IL4 TNF
33 11.48 IFNG IL10 IL4
34 11.37 AIRE CD40LG CD79A
35 11.34 IFNG IL10 TLR9 TNF
36 11.34 CD40LG IFNG IL10 TLR9 TNF
37 11.34 CD101 IFNG IL10 IL17A IL4 TNF
38 11.31 CD40LG IFNG IL4
39 11.28 IFNG IL17A IL4 TNF
40 11.23 IFNG IL10 IL4 TNF
41 11.2 IFNG IL10 IL4

GO Terms for Opportunistic Mycosis

Biological processes related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.95 IL10 IL17A IL4 STAT1 TNF
2 regulation of signaling receptor activity GO:0010469 9.85 CD40LG IFNG IL10 IL17A IL4 TNF
3 positive regulation of JNK cascade GO:0046330 9.81 CARD9 TLR9 TNF
4 humoral immune response GO:0006959 9.79 AIRE IFNG TNF
5 positive regulation of interleukin-6 production GO:0032755 9.75 CARD9 TLR9 TNF
6 inflammatory response GO:0006954 9.73 CD40LG CLEC7A IL10 IL17A TLR9 TNF
7 B cell proliferation GO:0042100 9.67 CD40LG CD79A IL10
8 response to molecule of bacterial origin GO:0002237 9.65 IL10 TLR9
9 B cell activation GO:0042113 9.65 CD79A IL4 SKAP2
10 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.64 IFNG STAT1
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
12 endothelial cell apoptotic process GO:0072577 9.63 IL10 TNF
13 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TLR9 TNF
14 interleukin-17-mediated signaling pathway GO:0097400 9.62 IL17A IL17RA
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 IL4
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 IL10 TNF
17 type 2 immune response GO:0042092 9.59 IL10 IL4
18 negative regulation of interleukin-8 production GO:0032717 9.58 IL10 TLR9
19 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG IFNG TLR9
20 regulation of immunoglobulin secretion GO:0051023 9.57 CD40LG TNF
21 regulation of isotype switching GO:0045191 9.56 IL10 IL4
22 fibroblast activation GO:0072537 9.54 IL17A IL17RA
23 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IFNG TNF
25 positive regulation of osteoclast differentiation GO:0045672 9.5 IFNG IL17A TNF
26 immune response GO:0006955 9.5 AIRE CD40LG IFNG IL10 IL17A IL4
27 B cell differentiation GO:0030183 9.46 CD40LG CD79A IL10 IL4
28 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
29 positive regulation of interleukin-23 production GO:0032747 8.8 IFNG IL17A IL17RA
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.15 AIRE IL10 IL17A IL4 STAT1 TLR9

Molecular functions related to Opportunistic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.13 CD40LG STAT1 TNF
2 cytokine activity GO:0005125 9.1 CD40LG IFNG IL10 IL17A IL4 TNF

Sources for Opportunistic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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