MCID: OPT005
MIFTS: 21

Optic Nerve Astrocytoma

Categories: Bone diseases, Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma 12 15 71
Astrocytic Tumor of Optic Nerve 12
Visual Pathway Astrocytoma 71
Optic Tract Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4991
NCIt 50 C6769 C7533
UMLS 71 C1335114 C1336971

Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and small cell carcinoma. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. Related phenotype is nervous system.

Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 childhood optic tract astrocytoma 11.3
2 small cell carcinoma 10.1 SYP ENO2
3 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
4 anal neuroendocrine tumor 10.1 SYP ENO2
5 large cell carcinoma 10.1 SYP ENO2
6 cerebral neuroblastoma 10.1 SYP ENO2
7 neuronal intestinal dysplasia, type b 10.1 SYP ENO2
8 lung meningioma 10.1 SYP ENO2
9 sinonasal undifferentiated carcinoma 10.1 SYP ENO2
10 auditory system benign neoplasm 10.1 SYP ENO2
11 papillary tumor of the pineal region 10.1 SYP ENO2
12 small cell carcinoma of the bladder 10.1 SYP ENO2
13 auditory system cancer 10.1 SYP ENO2
14 cloacogenic carcinoma 10.1 SYP ENO2
15 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 SYP ENO2
16 cauda equina neoplasm 10.1 SYP ENO2
17 intracranial primitive neuroectodermal tumor 10.1 SYP ENO2
18 bile duct mucinous adenocarcinoma 10.1 SYP ENO2
19 nodular prostate 10.1 SYP ENO2
20 ampulla of vater neoplasm 10.1 SYP ENO2
21 appendix carcinoid tumor 10.1 SYP ENO2
22 carotid body cancer 10.1 SYP ENO2
23 gallbladder small cell carcinoma 10.1 SYP ENO2
24 ureter small cell carcinoma 10.1 SYP ENO2
25 cerebellar liponeurocytoma 10.1 SYP ENO2
26 middle ear adenoma 10.1 SYP ENO2
27 cerebellopontine angle primitive neuroectodermal tumor 10.1 SYP ENO2
28 urinary bladder small cell neuroendocrine carcinoma 10.1 SYP ENO2
29 neuroendocrine carcinoma 10.1 SYP ENO2
30 glioma susceptibility 1 10.1
31 malignant astrocytoma 10.1
32 gastric small cell carcinoma 10.1 SYP ENO2
33 extracranial neuroblastoma 10.1 SYP ENO2
34 jejunal neoplasm 10.1 SYP ENO2
35 frontal lobe neoplasm 10.1 SYP ENO2
36 sensory organ benign neoplasm 10.1 SYP ENO2
37 cervical neuroblastoma 10.1 SYP ENO2
38 ovarian large-cell neuroendocrine carcinoma 10.1 SYP ENO2
39 gastric hemangioma 10.1 SYP ENO2
40 pineocytoma 10.1 SYP ENO2
41 pineal parenchymal tumor of intermediate differentiation 10.1 SYP ENO2
42 cutaneous ganglioneuroma 10.1 SYP ENO2
43 ganglioneuroma 10.1 SYP ENO2
44 cervix small cell carcinoma 10.1 SYP ENO2
45 endobronchial leiomyoma 10.1 SYP ENO2
46 adrenal neuroblastoma 10.1 SYP ENO2
47 gastrointestinal neuroendocrine tumor 10.1 SYP ENO2
48 carcinoid tumors, intestinal 10.1 SYP ENO2
49 endometrial small cell carcinoma 10.1 SYP ENO2
50 extraosseous ewing sarcoma 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:



Diseases related to Optic Nerve Astrocytoma

Symptoms & Phenotypes for Optic Nerve Astrocytoma

MGI Mouse Phenotypes related to Optic Nerve Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 ENO2 NF1 SMARCB1 SYP TSC2

Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

Genetic Tests for Optic Nerve Astrocytoma

Anatomical Context for Optic Nerve Astrocytoma

Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

# Title Authors PMID Year
1
Optic nerve astrocytoma in a dog. 61
27648262 2016
2
[Optic nerve astrocytoma--diagnostic difficulties]. 61
15598049 2004
3
Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. 61
9524084 1998
4
Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. 61
6470799 1984

Variations for Optic Nerve Astrocytoma

Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 SYP NF1 ENO2

GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 8.96 TSC2 NF1
2 negative regulation of cell proliferation GO:0008285 8.8 TSC2 SMARCB1 NF1

Sources for Optic Nerve Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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