MCID: OPT005
MIFTS: 23

Optic Nerve Astrocytoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma 12 15 71
Astrocytic Tumor of Optic Nerve 12
Visual Pathway Astrocytoma 71
Optic Tract Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4991
NCIt 49 C6769 C7533
UMLS 71 C1335114 C1336971

Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and pacinian tumor. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Eicosanoid Synthesis.

Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 childhood optic tract astrocytoma 12.5
2 pacinian tumor 10.4 NF1 ENO2
3 plexiform schwannoma 10.3 NF1 ENO2
4 orbital cancer 10.3 NF1 ENO2
5 skin granular cell tumor 10.3 NF1 ENO2
6 optic nerve glioma 10.3 NF1 ENO2
7 neurofibrosarcoma 10.3 NF1 ENO2
8 connective tissue benign neoplasm 10.2 NF1 ENO2
9 tuberculous meningitis 10.2 GGT1 ENO2
10 astrocytoma 10.2
11 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
12 ureter small cell carcinoma 10.0 SYP ENO2
13 anal neuroendocrine tumor 10.0 SYP ENO2
14 sinonasal undifferentiated carcinoma 10.0 SYP ENO2
15 cerebral neuroblastoma 10.0 SYP ENO2
16 papillary tumor of the pineal region 10.0 SYP ENO2
17 small cell carcinoma of the bladder 10.0 SYP ENO2
18 urinary bladder small cell neuroendocrine carcinoma 10.0 SYP ENO2
19 intracranial primitive neuroectodermal tumor 10.0 SYP ENO2
20 bile duct mucinous adenocarcinoma 10.0 SYP ENO2
21 nodular prostate 10.0 SYP ENO2
22 appendix carcinoid tumor 10.0 SYP ENO2
23 auditory system cancer 10.0 SYP ENO2
24 cloacogenic carcinoma 10.0 SYP ENO2
25 thymus small cell carcinoma 10.0 SYP ENO2
26 mature teratoma of the ovary 10.0 SYP ENO2
27 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.0 SYP ENO2
28 cauda equina neoplasm 10.0 SYP ENO2
29 cerebellopontine angle primitive neuroectodermal 10.0 SYP ENO2
30 duodenal benign neoplasm 10.0 SYP ENO2
31 ampulla of vater neoplasm 10.0 SYP ENO2
32 cerebellar liponeurocytoma 10.0 SYP ENO2
33 papillary ependymoma 10.0 SYP ENO2
34 middle ear adenoma 10.0 SYP ENO2
35 nodular ganglioneuroblastoma 10.0 SYP ENO2
36 ganglioneuroblastoma 10.0 SYP ENO2
37 carotid body cancer 10.0 SYP ENO2
38 gastric small cell carcinoma 10.0 SYP ENO2
39 jejunal neoplasm 10.0 SYP ENO2
40 frontal lobe neoplasm 10.0 SYP ENO2
41 sensory organ benign neoplasm 10.0 SYP ENO2
42 subependymoma 10.0 SYP ENO2
43 pineocytoma 10.0 SYP ENO2
44 cervical large cell neuroendocrine carcinoma 10.0 SYP ENO2
45 large cell neuroendocrine carcinoma 10.0 SYP ENO2
46 lung oat cell carcinoma 10.0 SYP ENO2
47 pineal parenchymal tumor of intermediate differentiation 10.0 SYP ENO2
48 cutaneous ganglioneuroma 10.0 SYP ENO2
49 ganglioneuroma 10.0 SYP ENO2
50 ascending cholangitis 10.0 GGTLC3 GGT2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:



Diseases related to Optic Nerve Astrocytoma

Symptoms & Phenotypes for Optic Nerve Astrocytoma

Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

Genetic Tests for Optic Nerve Astrocytoma

Anatomical Context for Optic Nerve Astrocytoma

Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

# Title Authors PMID Year
1
Optic nerve astrocytoma in a dog. 61
27648262 2016
2
[Optic nerve astrocytoma--diagnostic difficulties]. 61
15598049 2004
3
Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. 61
9524084 1998
4
Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. 61
6470799 1984

Variations for Optic Nerve Astrocytoma

Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.8 GGT2 GGT1
2 10.34 GGT2 GGT1
3 9.98 GGT2 GGT1

GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to tumor necrosis factor GO:0034612 9.4 GGT2 GGT1
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 SYP NF1
3 zymogen activation GO:0031638 9.32 GGT2 GGT1
4 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
5 peptide modification GO:0031179 9.16 GGT2 GGT1
6 leukotriene D4 biosynthetic process GO:1901750 9.13 GGTLC3 GGT2 GGT1
7 glutathione catabolic process GO:0006751 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Optic Nerve Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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