Optic Nerve Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma ¹² ¹⁵ ⁷¹

Astrocytic Tumor of Optic Nerve ¹²

Visual Pathway Astrocytoma ⁷¹

Optic Tract Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4991

NCIt ⁴⁹ C6769 C7533

UMLS ⁷¹ C1335114 C1336971

Sources

Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and pacinian tumor. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Eicosanoid Synthesis.

Sources

Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)

#	Related Disease	Score	Top Affiliating Genes
1	childhood optic tract astrocytoma	12.5
2	pacinian tumor	10.4	NF1 ENO2
3	plexiform schwannoma	10.3	NF1 ENO2
4	orbital cancer	10.3	NF1 ENO2
5	skin granular cell tumor	10.3	NF1 ENO2
6	optic nerve glioma	10.3	NF1 ENO2
7	neurofibrosarcoma	10.3	NF1 ENO2
8	connective tissue benign neoplasm	10.2	NF1 ENO2
9	tuberculous meningitis	10.2	GGT1 ENO2
10	astrocytoma	10.2
11	malignant melanocytic neoplasm of the peripheral nerve sheath	10.1	SYP ENO2
12	ureter small cell carcinoma	10.0	SYP ENO2
13	anal neuroendocrine tumor	10.0	SYP ENO2
14	sinonasal undifferentiated carcinoma	10.0	SYP ENO2
15	cerebral neuroblastoma	10.0	SYP ENO2
16	papillary tumor of the pineal region	10.0	SYP ENO2
17	small cell carcinoma of the bladder	10.0	SYP ENO2
18	urinary bladder small cell neuroendocrine carcinoma	10.0	SYP ENO2
19	intracranial primitive neuroectodermal tumor	10.0	SYP ENO2
20	bile duct mucinous adenocarcinoma	10.0	SYP ENO2
21	nodular prostate	10.0	SYP ENO2
22	appendix carcinoid tumor	10.0	SYP ENO2
23	auditory system cancer	10.0	SYP ENO2
24	cloacogenic carcinoma	10.0	SYP ENO2
25	thymus small cell carcinoma	10.0	SYP ENO2
26	mature teratoma of the ovary	10.0	SYP ENO2
27	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.0	SYP ENO2
28	cauda equina neoplasm	10.0	SYP ENO2
29	cerebellopontine angle primitive neuroectodermal	10.0	SYP ENO2
30	duodenal benign neoplasm	10.0	SYP ENO2
31	ampulla of vater neoplasm	10.0	SYP ENO2
32	cerebellar liponeurocytoma	10.0	SYP ENO2
33	papillary ependymoma	10.0	SYP ENO2
34	middle ear adenoma	10.0	SYP ENO2
35	nodular ganglioneuroblastoma	10.0	SYP ENO2
36	ganglioneuroblastoma	10.0	SYP ENO2
37	carotid body cancer	10.0	SYP ENO2
38	gastric small cell carcinoma	10.0	SYP ENO2
39	jejunal neoplasm	10.0	SYP ENO2
40	frontal lobe neoplasm	10.0	SYP ENO2
41	sensory organ benign neoplasm	10.0	SYP ENO2
42	subependymoma	10.0	SYP ENO2
43	pineocytoma	10.0	SYP ENO2
44	cervical large cell neuroendocrine carcinoma	10.0	SYP ENO2
45	large cell neuroendocrine carcinoma	10.0	SYP ENO2
46	lung oat cell carcinoma	10.0	SYP ENO2
47	pineal parenchymal tumor of intermediate differentiation	10.0	SYP ENO2
48	cutaneous ganglioneuroma	10.0	SYP ENO2
49	ganglioneuroma	10.0	SYP ENO2
50	ascending cholangitis	10.0	GGTLC3 GGT2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:

Sources

Symptoms & Phenotypes for Optic Nerve Astrocytoma

Sources

Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

Sources

Genetic Tests for Optic Nerve Astrocytoma

Sources

Anatomical Context for Optic Nerve Astrocytoma

Sources

Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

#	Title	Authors	PMID	Year
1	Optic nerve astrocytoma in a dog. ⁶¹	Rozov O...Dreyfus J	27648262	2016
2	[Optic nerve astrocytoma--diagnostic difficulties]. ⁶¹	Daraba E...Robu M	15598049	2004
3	Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. ⁶¹	Kato T...Abe H	9524084	1998
4	Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. ⁶¹	Iraci G...Gerosa MA	6470799	1984

Sources

Genes for Optic Nerve Astrocytoma

Genes related to Optic Nerve Astrocytoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	5.46	DISEASES inferred ¹⁵
2	POU3F3	POU Class 3 Homeobox 3	Protein Coding	5.27	DISEASES inferred ¹⁵
3	KAT8	Lysine Acetyltransferase 8	Protein Coding	5.16	DISEASES inferred ¹⁵
4	NF1	Neurofibromin 1	Protein Coding	5.01	DISEASES inferred ¹⁵
5	MCOLN1	Mucolipin 1	Protein Coding	4.92	DISEASES inferred ¹⁵
6	GGTLC3	Gamma-Glutamyltransferase Light Chain Family Member 3	Protein Coding	3.75	DISEASES inferred ¹⁵
7	GGT2	Gamma-Glutamyltransferase 2	Protein Coding	3.74	DISEASES inferred ¹⁵
8	SYP	Synaptophysin	Protein Coding	3.74	DISEASES inferred ¹⁵
9	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	3.72	DISEASES inferred ¹⁵

Sources

Variations for Optic Nerve Astrocytoma

Sources

Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

Sources

Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁵	10.8	GGT2 GGT1
2	Eicosanoid Synthesis ¹	10.34	GGT2 GGT1
3	Aflatoxin activation and detoxification ⁶⁵	9.98	GGT2 GGT1

Sources

GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to tumor necrosis factor	GO:0034612	9.4	GGT2 GGT1
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.37	SYP NF1
3	zymogen activation	GO:0031638	9.32	GGT2 GGT1
4	regulation of immune system process	GO:0002682	9.26	GGT2 GGT1
5	peptide modification	GO:0031179	9.16	GGT2 GGT1
6	leukotriene D4 biosynthetic process	GO:1901750	9.13	GGTLC3 GGT2 GGT1
7	glutathione catabolic process	GO:0006751	8.8	GGTLC3 GGT2 GGT1

Molecular functions related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyltransferase activity	GO:0000048	8.96	GGT2 GGT1
2	glutathione hydrolase activity	GO:0036374	8.8	GGTLC3 GGT2 GGT1

Sources

Sources for Optic Nerve Astrocytoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia