MCID: OPT005
MIFTS: 24

Optic Nerve Astrocytoma

Categories: Bone diseases, Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma 12 15 71
Astrocytic Tumor of Optic Nerve 12
Visual Pathway Astrocytoma 71
Optic Tract Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4991
NCIt 49 C6769 C7533
UMLS 71 C1335114 C1336971

Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and pacinian tumor. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Eicosanoid Synthesis and Aflatoxin activation and detoxification. Affiliated tissues include bone.

Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 childhood optic tract astrocytoma 12.5
2 pacinian tumor 10.4 NF1 ENO2
3 plexiform schwannoma 10.4 NF1 ENO2
4 malignant triton tumor 10.4 NF1 ENO2
5 skin granular cell tumor 10.4 NF1 ENO2
6 large cell carcinoma with rhabdoid phenotype 10.3 SMARCB1 ENO2
7 acute monoblastic leukemia 10.3 TSC2 NF1
8 kidney rhabdoid cancer 10.3 SMARCB1 ENO2
9 optic nerve glioma 10.3 NF1 ENO2
10 cellular neurofibroma 10.3 SMARCB1 NF1
11 neurofibrosarcoma 10.3 NF1 ENO2
12 peripheral nerve schwannoma 10.3 SMARCB1 NF1
13 optic nerve sheath meningioma 10.2 SMARCB1 NF1
14 optic nerve neoplasm 10.2 SMARCB1 NF1
15 subependymal glioma 10.2 TSC2 NF1
16 spinal canal and spinal cord meningioma 10.2 SMARCB1 NF1
17 spinal meningioma 10.2 SMARCB1 NF1
18 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 NF1
19 tuberculous meningitis 10.2 GGT1 ENO2
20 somatostatinoma 10.2 NF1 ENO2
21 schwannoma of twelfth cranial nerve 10.2 SMARCB1 NF1
22 hypoglossal nerve disease 10.2 SMARCB1 NF1
23 connective tissue benign neoplasm 10.2 TSC2 NF1 ENO2
24 corpus callosum lipoma 10.2 SMARCB1 NF1
25 astrocytoma 10.2
26 cerebral hemisphere lipoma 10.2 SMARCB1 NF1
27 cerebral falx meningioma 10.2 NF1 KAT8 ENO2
28 sturge-weber syndrome 10.2 TSC2 NF1
29 mature teratoma 10.1 SYP ENO2
30 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
31 anal neuroendocrine tumor 10.1 SYP ENO2
32 breast neuroendocrine neoplasm 10.1 SYP ENO2
33 sinonasal undifferentiated carcinoma 10.1 SYP ENO2
34 cerebral neuroblastoma 10.1 SYP ENO2
35 papillary tumor of the pineal region 10.1 SYP ENO2
36 small cell carcinoma of the bladder 10.1 SYP ENO2
37 intracranial primitive neuroectodermal tumor 10.1 SYP ENO2
38 bile duct mucinous adenocarcinoma 10.1 SYP ENO2
39 auditory system benign neoplasm 10.1 SYP ENO2
40 appendix carcinoid tumor 10.1 SYP ENO2
41 neurilemmoma 10.1 SMARCB1 NF1 ENO2
42 auditory system cancer 10.1 SYP ENO2
43 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 SYP ENO2
44 neuroma 10.1 SMARCB1 NF1 ENO2
45 cauda equina neoplasm 10.1 SYP ENO2
46 cerebellopontine angle primitive neuroectodermal tumor 10.1 SYP ENO2
47 duodenal benign neoplasm 10.0 SYP ENO2
48 nodular prostate 10.0 SYP ENO2
49 ampulla of vater neoplasm 10.0 SYP ENO2
50 urinary bladder small cell neuroendocrine carcinoma 10.0 SYP ENO2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:



Diseases related to Optic Nerve Astrocytoma

Symptoms & Phenotypes for Optic Nerve Astrocytoma

Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

Genetic Tests for Optic Nerve Astrocytoma

Anatomical Context for Optic Nerve Astrocytoma

MalaCards organs/tissues related to Optic Nerve Astrocytoma:

40
Bone

Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

# Title Authors PMID Year
1
Optic nerve astrocytoma in a dog. 61
27648262 2016
2
[Optic nerve astrocytoma--diagnostic difficulties]. 61
15598049 2004
3
Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. 61
9524084 1998
4
Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. 61
6470799 1984

Variations for Optic Nerve Astrocytoma

Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.34 GGT2 GGT1
2 9.98 GGT2 GGT1

GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to tumor necrosis factor GO:0034612 9.4 GGT2 GGT1
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 SYP NF1
3 zymogen activation GO:0031638 9.32 GGT2 GGT1
4 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
5 peptide modification GO:0031179 9.16 GGT2 GGT1
6 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
7 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Optic Nerve Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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