Optic Nerve Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma ¹² ¹⁵ ⁷¹

Astrocytic Tumor of Optic Nerve ¹²

Visual Pathway Astrocytoma ⁷¹

Optic Tract Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4991

NCIt ⁵⁰ C6769 C7533

UMLS ⁷¹ C1335114 C1336971

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Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and small cell carcinoma. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. Related phenotype is nervous system.

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Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)

#	Related Disease	Score	Top Affiliating Genes
1	childhood optic tract astrocytoma	11.3
2	small cell carcinoma	10.1	SYP ENO2
3	malignant melanocytic neoplasm of the peripheral nerve sheath	10.1	SYP ENO2
4	anal neuroendocrine tumor	10.1	SYP ENO2
5	large cell carcinoma	10.1	SYP ENO2
6	cerebral neuroblastoma	10.1	SYP ENO2
7	neuronal intestinal dysplasia, type b	10.1	SYP ENO2
8	lung meningioma	10.1	SYP ENO2
9	sinonasal undifferentiated carcinoma	10.1	SYP ENO2
10	auditory system benign neoplasm	10.1	SYP ENO2
11	papillary tumor of the pineal region	10.1	SYP ENO2
12	small cell carcinoma of the bladder	10.1	SYP ENO2
13	auditory system cancer	10.1	SYP ENO2
14	cloacogenic carcinoma	10.1	SYP ENO2
15	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.1	SYP ENO2
16	cauda equina neoplasm	10.1	SYP ENO2
17	intracranial primitive neuroectodermal tumor	10.1	SYP ENO2
18	bile duct mucinous adenocarcinoma	10.1	SYP ENO2
19	nodular prostate	10.1	SYP ENO2
20	ampulla of vater neoplasm	10.1	SYP ENO2
21	appendix carcinoid tumor	10.1	SYP ENO2
22	carotid body cancer	10.1	SYP ENO2
23	gallbladder small cell carcinoma	10.1	SYP ENO2
24	ureter small cell carcinoma	10.1	SYP ENO2
25	cerebellar liponeurocytoma	10.1	SYP ENO2
26	middle ear adenoma	10.1	SYP ENO2
27	cerebellopontine angle primitive neuroectodermal tumor	10.1	SYP ENO2
28	urinary bladder small cell neuroendocrine carcinoma	10.1	SYP ENO2
29	neuroendocrine carcinoma	10.1	SYP ENO2
30	glioma susceptibility 1	10.1
31	malignant astrocytoma	10.1
32	gastric small cell carcinoma	10.1	SYP ENO2
33	extracranial neuroblastoma	10.1	SYP ENO2
34	jejunal neoplasm	10.1	SYP ENO2
35	frontal lobe neoplasm	10.1	SYP ENO2
36	sensory organ benign neoplasm	10.1	SYP ENO2
37	cervical neuroblastoma	10.1	SYP ENO2
38	ovarian large-cell neuroendocrine carcinoma	10.1	SYP ENO2
39	gastric hemangioma	10.1	SYP ENO2
40	pineocytoma	10.1	SYP ENO2
41	pineal parenchymal tumor of intermediate differentiation	10.1	SYP ENO2
42	cutaneous ganglioneuroma	10.1	SYP ENO2
43	ganglioneuroma	10.1	SYP ENO2
44	cervix small cell carcinoma	10.1	SYP ENO2
45	endobronchial leiomyoma	10.1	SYP ENO2
46	adrenal neuroblastoma	10.1	SYP ENO2
47	gastrointestinal neuroendocrine tumor	10.1	SYP ENO2
48	carcinoid tumors, intestinal	10.1	SYP ENO2
49	endometrial small cell carcinoma	10.1	SYP ENO2
50	extraosseous ewing sarcoma	10.1	SYP ENO2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:

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Symptoms & Phenotypes for Optic Nerve Astrocytoma

MGI Mouse Phenotypes related to Optic Nerve Astrocytoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.02	ENO2 NF1 SMARCB1 SYP TSC2

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Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

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Genetic Tests for Optic Nerve Astrocytoma

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Anatomical Context for Optic Nerve Astrocytoma

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Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

#	Title	Authors	PMID	Year
1	Optic nerve astrocytoma in a dog. ⁶¹	Rozov O...Dreyfus J	27648262	2016
2	[Optic nerve astrocytoma--diagnostic difficulties]. ⁶¹	Daraba E...Robu M	15598049	2004
3	Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. ⁶¹	Kato T...Abe H	9524084	1998
4	Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. ⁶¹	Iraci G...Gerosa MA	6470799	1984

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Genes for Optic Nerve Astrocytoma

Genes related to Optic Nerve Astrocytoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	5.46	DISEASES inferred ¹⁵
2	TSC2	TSC Complex Subunit 2	Protein Coding	5.3	DISEASES inferred ¹⁵
3	NF1	Neurofibromin 1	Protein Coding	4.97	DISEASES inferred ¹⁵
4	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.33	DISEASES inferred ¹⁵
5	SYP	Synaptophysin	Protein Coding	3.73	DISEASES inferred ¹⁵

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Variations for Optic Nerve Astrocytoma

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Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

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Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.33	SYP NF1 ENO2

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GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of protein kinase activity	GO:0006469	8.96	TSC2 NF1
2	negative regulation of cell proliferation	GO:0008285	8.8	TSC2 SMARCB1 NF1

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