Optic Nerve Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Optic Nerve Astrocytoma

MalaCards integrated aliases for Optic Nerve Astrocytoma:

Name: Optic Nerve Astrocytoma ¹² ¹⁵ ⁷¹

Astrocytic Tumor of Optic Nerve ¹²

Visual Pathway Astrocytoma ⁷¹

Optic Tract Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Bone diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4991

NCIt ⁴⁹ C6769 C7533

UMLS ⁷¹ C1335114 C1336971

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Summaries for Optic Nerve Astrocytoma

MalaCards based summary : Optic Nerve Astrocytoma, also known as astrocytic tumor of optic nerve, is related to childhood optic tract astrocytoma and pacinian tumor. An important gene associated with Optic Nerve Astrocytoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Eicosanoid Synthesis and Aflatoxin activation and detoxification. Affiliated tissues include bone.

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Related Diseases for Optic Nerve Astrocytoma

Diseases related to Optic Nerve Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)

#	Related Disease	Score	Top Affiliating Genes
1	childhood optic tract astrocytoma	12.5
2	pacinian tumor	10.4	NF1 ENO2
3	plexiform schwannoma	10.4	NF1 ENO2
4	malignant triton tumor	10.4	NF1 ENO2
5	skin granular cell tumor	10.4	NF1 ENO2
6	large cell carcinoma with rhabdoid phenotype	10.3	SMARCB1 ENO2
7	acute monoblastic leukemia	10.3	TSC2 NF1
8	kidney rhabdoid cancer	10.3	SMARCB1 ENO2
9	optic nerve glioma	10.3	NF1 ENO2
10	cellular neurofibroma	10.3	SMARCB1 NF1
11	neurofibrosarcoma	10.3	NF1 ENO2
12	peripheral nerve schwannoma	10.3	SMARCB1 NF1
13	optic nerve sheath meningioma	10.2	SMARCB1 NF1
14	optic nerve neoplasm	10.2	SMARCB1 NF1
15	subependymal glioma	10.2	TSC2 NF1
16	spinal canal and spinal cord meningioma	10.2	SMARCB1 NF1
17	spinal meningioma	10.2	SMARCB1 NF1
18	epithelioid malignant peripheral nerve sheath tumor	10.2	SMARCB1 NF1
19	tuberculous meningitis	10.2	GGT1 ENO2
20	somatostatinoma	10.2	NF1 ENO2
21	schwannoma of twelfth cranial nerve	10.2	SMARCB1 NF1
22	hypoglossal nerve disease	10.2	SMARCB1 NF1
23	connective tissue benign neoplasm	10.2	TSC2 NF1 ENO2
24	corpus callosum lipoma	10.2	SMARCB1 NF1
25	astrocytoma	10.2
26	cerebral hemisphere lipoma	10.2	SMARCB1 NF1
27	cerebral falx meningioma	10.2	NF1 KAT8 ENO2
28	sturge-weber syndrome	10.2	TSC2 NF1
29	mature teratoma	10.1	SYP ENO2
30	malignant melanocytic neoplasm of the peripheral nerve sheath	10.1	SYP ENO2
31	anal neuroendocrine tumor	10.1	SYP ENO2
32	breast neuroendocrine neoplasm	10.1	SYP ENO2
33	sinonasal undifferentiated carcinoma	10.1	SYP ENO2
34	cerebral neuroblastoma	10.1	SYP ENO2
35	papillary tumor of the pineal region	10.1	SYP ENO2
36	small cell carcinoma of the bladder	10.1	SYP ENO2
37	intracranial primitive neuroectodermal tumor	10.1	SYP ENO2
38	bile duct mucinous adenocarcinoma	10.1	SYP ENO2
39	auditory system benign neoplasm	10.1	SYP ENO2
40	appendix carcinoid tumor	10.1	SYP ENO2
41	neurilemmoma	10.1	SMARCB1 NF1 ENO2
42	auditory system cancer	10.1	SYP ENO2
43	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.1	SYP ENO2
44	neuroma	10.1	SMARCB1 NF1 ENO2
45	cauda equina neoplasm	10.1	SYP ENO2
46	cerebellopontine angle primitive neuroectodermal tumor	10.1	SYP ENO2
47	duodenal benign neoplasm	10.0	SYP ENO2
48	nodular prostate	10.0	SYP ENO2
49	ampulla of vater neoplasm	10.0	SYP ENO2
50	urinary bladder small cell neuroendocrine carcinoma	10.0	SYP ENO2

Graphical network of the top 20 diseases related to Optic Nerve Astrocytoma:

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Symptoms & Phenotypes for Optic Nerve Astrocytoma

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Drugs & Therapeutics for Optic Nerve Astrocytoma

Search Clinical Trials , NIH Clinical Center for Optic Nerve Astrocytoma

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Genetic Tests for Optic Nerve Astrocytoma

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Anatomical Context for Optic Nerve Astrocytoma

MalaCards organs/tissues related to Optic Nerve Astrocytoma:

⁴⁰

Bone

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Publications for Optic Nerve Astrocytoma

Articles related to Optic Nerve Astrocytoma:

#	Title	Authors	PMID	Year
1	Optic nerve astrocytoma in a dog. ⁶¹	Rozov O...Dreyfus J	27648262	2016
2	[Optic nerve astrocytoma--diagnostic difficulties]. ⁶¹	Daraba E...Robu M	15598049	2004
3	Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. ⁶¹	Kato T...Abe H	9524084	1998
4	Spontaneous ("erosive") cerebrospinal rhinorrhea, with pneumococcal meningitis from anterior optic glioma. Case report. ⁶¹	Iraci G...Gerosa MA	6470799	1984

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Genes for Optic Nerve Astrocytoma

Genes related to Optic Nerve Astrocytoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	5.35	DISEASES inferred ¹⁵
2	TSC2	TSC Complex Subunit 2	Protein Coding	5.2	DISEASES inferred ¹⁵
3	POU3F3	POU Class 3 Homeobox 3	Protein Coding	5.1	DISEASES inferred ¹⁵
4	KAT8	Lysine Acetyltransferase 8	Protein Coding	5.03	DISEASES inferred ¹⁵
5	NF1	Neurofibromin 1	Protein Coding	4.91	DISEASES inferred ¹⁵
6	MCOLN1	Mucolipin 1	Protein Coding	4.72	DISEASES inferred ¹⁵
7	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.25	DISEASES inferred ¹⁵
8	GGTLC3	Gamma-Glutamyltransferase Light Chain Family Member 3	Protein Coding	3.64	DISEASES inferred ¹⁵
9	GGT2	Gamma-Glutamyltransferase 2	Protein Coding	3.64	DISEASES inferred ¹⁵
10	SYP	Synaptophysin	Protein Coding	3.62	DISEASES inferred ¹⁵
11	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	3.61	DISEASES inferred ¹⁵

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Variations for Optic Nerve Astrocytoma

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Expression for Optic Nerve Astrocytoma

Search GEO for disease gene expression data for Optic Nerve Astrocytoma.

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Pathways for Optic Nerve Astrocytoma

Pathways related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Eicosanoid Synthesis ¹	10.34	GGT2 GGT1
2	Aflatoxin activation and detoxification ⁶⁵	9.98	GGT2 GGT1

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GO Terms for Optic Nerve Astrocytoma

Biological processes related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to tumor necrosis factor	GO:0034612	9.4	GGT2 GGT1
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.37	SYP NF1
3	zymogen activation	GO:0031638	9.32	GGT2 GGT1
4	regulation of immune system process	GO:0002682	9.26	GGT2 GGT1
5	peptide modification	GO:0031179	9.16	GGT2 GGT1
6	glutathione catabolic process	GO:0006751	9.13	GGTLC3 GGT2 GGT1
7	leukotriene D4 biosynthetic process	GO:1901750	8.8	GGTLC3 GGT2 GGT1

Molecular functions related to Optic Nerve Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyltransferase activity	GO:0000048	8.96	GGT2 GGT1
2	glutathione hydrolase activity	GO:0036374	8.8	GGTLC3 GGT2 GGT1

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Sources for Optic Nerve Astrocytoma

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