Optic Nerve Glioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OPT007 MIFTS: 44	Optic Nerve Glioma Categories: Cancer diseases, Eye diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Optic Nerve Glioma

MalaCards integrated aliases for Optic Nerve Glioma:

Name: Optic Nerve Glioma ¹² ²⁹ ⁶ ⁴⁴ ¹⁵ ⁷³

Glioma of the Optic Nerve ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4992

MeSH ⁴⁴ D020339

NCIt ⁵⁰ C4537

UMLS ⁷³ C0346326

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Summaries for Optic Nerve Glioma

MalaCards based summary : Optic Nerve Glioma, also known as glioma of the optic nerve, is related to neurofibroma and childhood optic nerve glioma. An important gene associated with Optic Nerve Glioma is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Neuroscience and Interleukin-4 and 13 signaling. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and lung, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : ⁷⁶ Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of... more...

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Related Diseases for Optic Nerve Glioma

Diseases related to Optic Nerve Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)

#	Related Disease	Score	Top Affiliating Genes
1	neurofibroma	29.8	MUC1 NF1 S100B SYP
2	childhood optic nerve glioma	12.5
3	neurofibromatosis-noonan syndrome	11.2
4	glioma	10.9
5	duodenal somatostatinoma	10.3	ENO2 NF1
6	central nervous system germ cell tumor	10.3	GFAP NES
7	epithelioid leiomyosarcoma	10.3	ENO2 VIM
8	epulis	10.3	ENO2 VIM
9	multicentric reticulohistiocytosis	10.3	TNFRSF11B VIM
10	cerebellar medulloblastoma	10.3	ENO2 GFAP
11	melanotic medulloblastoma	10.3	ENO2 GFAP
12	microcystic meningioma	10.3	ENO2 GFAP
13	microcystic adenoma	10.3	ENO2 MUC1
14	malignant triton tumor	10.3	NF1 S100B
15	middle cerebral artery infarction	10.3	ENO2 S100B
16	hydrocephalus due to congenital stenosis of aqueduct of sylvius	10.3	MBP NES
17	rhabdoid meningioma	10.3	GFAP VIM
18	cutaneous leiomyosarcoma	10.3	GFAP VIM
19	nodular hidradenoma	10.3	MUC1 VIM
20	adenofibroma	10.3	MUC1 VIM
21	endometrial mucinous adenocarcinoma	10.3	MUC1 VIM
22	secretory meningioma	10.3	MUC1 VIM
23	bile duct adenoma	10.3	MUC1 VIM
24	biphasic synovial sarcoma	10.3	MUC1 VIM
25	finger agnosia	10.3	ENO2 MBP
26	head injury	10.3	ENO2 S100B
27	malignant peritoneal mesothelioma	10.3	MUC1 VIM
28	neonatal hypoxic and ischemic brain injury	10.3	ENO2 MBP
29	gemistocytic astrocytoma	10.3	GFAP S100B
30	aggressive digital papillary adenocarcinoma	10.3	MUC1 S100B
31	non-functioning pituitary adenoma	10.3	MUC1 S100B
32	reticular perineurioma	10.3	MUC1 S100B
33	scleral staphyloma	10.3	NF1 OPTN
34	malignant glandular tumor of peripheral nerve sheath	10.2	NF1 SYP
35	pancreatic somatostatinoma	10.2	ENO2 SYP
36	sensory organ benign neoplasm	10.2	ENO2 SYP
37	cutaneous ganglioneuroma	10.2	ENO2 SYP
38	extrahepatic bile duct adenocarcinoma	10.2	ENO2 SYP
39	olfactory nerve neoplasm	10.2	ENO2 SYP
40	orbital cancer	10.2	ENO2 SYP
41	extraosseous chondrosarcoma	10.2	ENO2 SYP
42	cauda equina neoplasm	10.2	ENO2 SYP
43	pulmonary large cell neuroendocrine carcinoma	10.2	ENO2 SYP
44	urinary bladder small cell neuroendocrine carcinoma	10.2	ENO2 SYP
45	gallbladder small cell carcinoma	10.2	ENO2 SYP
46	endometrial small cell carcinoma	10.2	ENO2 SYP
47	auditory system cancer	10.2	ENO2 SYP
48	small cell carcinoma of the bladder	10.2	ENO2 SYP
49	giant cell tumor	10.2	MUC1 TNFRSF11B VIM
50	plexiform schwannoma	10.2	ENO2 GFAP NF1

Graphical network of the top 20 diseases related to Optic Nerve Glioma:

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Symptoms & Phenotypes for Optic Nerve Glioma

MGI Mouse Phenotypes related to Optic Nerve Glioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.15	ENO2 FABP7 GFAP LOX MAP2 MBP
2	cardiovascular system	MP:0005385	9.97	GFAP H2AFX LOX MIB1 MTO1 NF1
3	cellular	MP:0005384	9.96	ENO2 GFAP H2AFX MBP MIB1 MTO1
4	homeostasis/metabolism	MP:0005376	9.93	FABP7 GFAP H2AFX LOX MBP MIB1
5	mortality/aging	MP:0010768	9.73	GFAP H2AFX LOX MAP2 MBP MIB1
6	nervous system	MP:0003631	9.32	ENO2 FABP7 GFAP MAP2 MBP MIB1

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Drugs & Therapeutics for Optic Nerve Glioma

Drugs for Optic Nerve Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dacarbazine

Approved, Investigational

Phase 3,Phase 1,Phase 2,Early Phase 1

4342-03-4

5351166

Temozolomide

Approved, Investigational

Phase 3,Phase 1,Phase 2,Early Phase 1

85622-93-1

5394

Carboplatin

Approved

Phase 3,Phase 1,Phase 2

41575-94-4

10339178 38904 498142

Alkylating Agents

Phase 3,Phase 1,Phase 2,Early Phase 1

Antineoplastic Agents, Alkylating

Phase 3,Phase 1,Phase 2,Early Phase 1

Oxaliplatin

Approved, Investigational

Phase 2,Phase 1

61825-94-3

43805 6857599 5310940 9887054

Irinotecan

Approved, Investigational

Phase 2,Phase 1

100286-90-6, 97682-44-5

60838

Lenalidomide

Approved

Phase 2,Phase 1

191732-72-6

216326

Vincristine

Approved, Investigational

Phase 1, Phase 2

57-22-7, 2068-78-2

5978

Bevacizumab

Approved, Investigational

Phase 1, Phase 2

216974-75-3

Mebendazole

Approved, Vet_approved

Phase 1, Phase 2

31431-39-7

4030

Piperazine

Approved, Vet_approved

Phase 1, Phase 2

110-85-0

4837

Peginterferon alfa-2b

Approved

Phase 2

99210-65-8, 215647-85-1

Trioxsalen

Approved

Phase 2,Phase 1

3902-71-4

5585

Nicotinamide

Approved, Investigational

Phase 2

98-92-0

936

Sorafenib

Approved, Investigational

Phase 2

284461-73-0

216239 406563

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 1, Phase 2

77-92-9

311

Niacin

Approved, Investigational, Nutraceutical

Phase 2

59-67-6

938

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

tipifarnib

Investigational

Phase 2

192185-72-1

159324

Camptothecin

Experimental

Phase 2,Phase 1

7689-03-4

Antineoplastic Agents, Phytogenic

Phase 2,Phase 1

topoisomerase I inhibitors

Phase 2,Phase 1

Topoisomerase Inhibitors

Phase 2,Phase 1

Anti-Infective Agents

Phase 1, Phase 2,Phase 2

Angiogenesis Modulating Agents

Phase 1, Phase 2,Phase 2

Angiogenesis Inhibitors

Phase 1, Phase 2,Phase 2

Immunologic Factors

Phase 2,Phase 1

Anti-Bacterial Agents

Phase 2,Phase 1

Immunosuppressive Agents

Phase 2,Phase 1

Protein Kinase Inhibitors

Phase 2,Phase 1

Anthelmintics

Phase 1, Phase 2

Antiparasitic Agents

Phase 1, Phase 2

Citrate

Phase 1, Phase 2

Anticonvulsants

Phase 1, Phase 2

Antimitotic Agents

Phase 1, Phase 2

Piperazine citrate

Phase 1, Phase 2

Antiviral Agents

Phase 2

interferons

Phase 2

Interferon-alpha

Phase 2

Photosensitizing Agents

Phase 2,Phase 1

Hematoporphyrin Derivative

Phase 2,Phase 1

Dermatologic Agents

Phase 2,Phase 1

Hematoporphyrins

Phase 2,Phase 1

Dihematoporphyrin Ether

Phase 2,Phase 1

Ether

Phase 2,Phase 1

Pharmaceutical Solutions

Phase 2

Vitamin B9

Phase 2

Nicotinic Acids

Phase 2

Vitamins

Phase 2

Interventional clinical trials:

(show all 40)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 3 Study of ANP Therapy vs. TMZ for Optic Pathway Glioma	Withdrawn	NCT01260103	Phase 3	Temozolomide;ANP Therapy
2	Antineoplaston Therapy in Treating Children With Visual Pathway Glioma	Completed	NCT00003477	Phase 2	Antineoplaston therapy (Atengenal + Astugenal)
3	Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy	Completed	NCT00679354	Phase 2	cilengitide
4	Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment	Completed	NCT00091182	Phase 2	oxaliplatin
5	Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma	Completed	NCT00070525	Phase 2	tipifarnib
6	Irinotecan in Treating Children With Refractory Solid Tumors	Completed	NCT00004078	Phase 2	irinotecan hydrochloride
7	A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas	Recruiting	NCT01837862	Phase 1, Phase 2	Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
8	Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma	Recruiting	NCT02839720	Phase 2	Selumetinib
9	Phase II Pegylated Interferon	Recruiting	NCT02343224	Phase 2	Pegylated interferon alpha-2b
10	Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma	Recruiting	NCT01089101	Phase 1, Phase 2	Selumetinib
11	Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas	Active, not recruiting	NCT01966809	Phase 2	Photofrin photodynamic therapy.
12	Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma	Active, not recruiting	NCT01553149	Phase 2	Lenalidomide
13	Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours	Not yet recruiting	NCT03326388	Phase 1, Phase 2	Selumetinib
14	Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas	Terminated	NCT01338857	Phase 2	Sorafenib (Nexavar)
15	Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors	Completed	NCT01076530	Phase 1	vorinostat;temozolomide
16	Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma	Completed	NCT00994500	Phase 1	vorinostat;bortezomib
17	ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors	Completed	NCT00946335	Phase 1	veliparib;temozolomide
18	Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment	Completed	NCT00929903	Phase 1	pazopanib hydrochloride
19	Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma	Completed	NCT00363272	Phase 1	ispinesib
20	AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors	Completed	NCT00326664	Phase 1	Cediranib Maleate
21	Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas	Completed	NCT00101270	Phase 1	irinotecan hydrochloride;oxaliplatin
22	Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors	Completed	NCT00100880	Phase 1	lenalidomide
23	Cilengitide in Treating Children With Refractory Primary Brain Tumors	Completed	NCT00063973	Phase 1	cilengitide
24	FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia	Completed	NCT00053963	Phase 1	romidepsin
25	Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors	Completed	NCT00052780	Phase 1	O6-benzylguanine;temozolomide
26	Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas	Completed	NCT00012181	Phase 1	alvocidib
27	Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors	Recruiting	NCT02372409	Phase 1	Doxorubicin;Etoposide
28	Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors	Recruiting	NCT01682746	Phase 1	Photofrin (porfimer sodium) & photodynamic therapy.
29	Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors	Recruiting	NCT02780804	Phase 1	Entinostat
30	Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors	Active, not recruiting	NCT02415153	Phase 1	Pomalidomide
31	Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor	Active, not recruiting	NCT00638898	Phase 1	busulfan;melphalan;topotecan hydrochloride
32	Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia	Terminated	NCT01088763	Phase 1	gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
33	Ophthalmological Screening and Follow-up of Optic Pathway Gliomas in Children With Neurofibromatosis Type 1.	Unknown status	NCT02078401
34	Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors	Completed	NCT00919750
35	Collecting and Storing Tissue From Young Patients With Cancer	Completed	NCT00898755
36	Natural History Study of Patients With Neurofibromatosis Type I	Recruiting	NCT00924196
37	PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1)	Active, not recruiting	NCT01800032
38	18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas	Terminated	NCT02175745	Not Applicable	18F-fluoro-dihydroxyphenylalanine
39	Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas	Withdrawn	NCT02976441	Early Phase 1	Temozolomide
40	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Withdrawn	NCT02194452	Not Applicable

Search NIH Clinical Center for Optic Nerve Glioma

Cochrane evidence based reviews: optic nerve glioma

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Genetic Tests for Optic Nerve Glioma

Genetic tests related to Optic Nerve Glioma:

#	Genetic test	Affiliating Genes
1	Optic Nerve Glioma ²⁹

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Anatomical Context for Optic Nerve Glioma

MalaCards organs/tissues related to Optic Nerve Glioma:

⁴¹

Brain, Eye, Lung, Spinal Cord, Pituitary, Cervix, Pineal

Sources

Publications for Optic Nerve Glioma

Articles related to Optic Nerve Glioma:

(show top 50) (show all 116)

#	Title	Authors	Year
1	Progressive optic nerve glioma: orbital biopsy technique using a surgical navigation system. ( 29426453 )	Hussain A....DeAngelis D.	2018
2	Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis: Retrospective Characterization and Analysis of Outcomes. ( 29502465 )	Hamideh D....Qaddoumi I.	2018
3	Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1. ( 29294511 )		2018
4	Optic nerve glioma with complete intraocular extension. ( 27830210 )	Eghtedari M....Geramizadeh B.	2016
5	Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome. ( 27230830 )	Borghei-Razavi H....Schick U.	2016
6	Childhood Optic Nerve Glioma: Vision Loss Due to Biopsy. ( 27046034 )	Revere K.E....Liu G.T.	2016
7	Teaching NeuroImages: Optic nerve glioma with perineural arachnoid gliomatosis in a patient with neurofibromatosis-1. ( 25825471 )		2015
8	Optic nerve glioma: an update. ( 24736941 )	Nair A.G....Gandhi R.A.	2014
9	Anisometropia in children with neurofibromatosis type 1 and unilateral optic nerve glioma. ( 24924279 )	Dotan G....Kesler A.	2014
10	Aggressive Low-Grade Optic Nerve Glioma in Adults. ( 27928317 )		2014
11	Optic nerve glioma: A great mimicker. ( 24575324 )		2014
12	An 80-year experience with optic nerve glioma cases at the Armed Forces Institute of Pathology: evolution from museum to molecular evaluation suggests possibe interventions in the cellular senescence and microglial pathways (an American Ophthalmological Society thesis). ( 25411512 )		2014
13	Optic nerve glioma: case series with review of clinical, radiologic, molecular, and histopathologic characteristics. ( 24762952 )	Glass LR...Kazim M	2014
14	Optic nerve glioma treatment with fractionated stereotactic radiotherapy. ( 23495806 )	Uslu N....Guney Y.	2013
15	Surgical management of an optic nerve glioma with perineural arachnoidal gliomatosis growth pattern. ( 23149617 )	Chen A....McCulley T.J.	2013
16	Fractionated stereotactic radiotherapy using Novalis for confined intra-orbital optic nerve glioma in pediatric patient. ( 23338672 )		2013
17	Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery. ( 23715516 )	Spicer GJ...Sullivan TJ	2013
18	Morning glory disc anomaly in association with ipsilateral optic nerve glioma. ( 22893090 )	Bandopadhayay P....Ullrich N.J.	2012
19	Diagnosis and management of optic nerve glioma. ( 22071462 )	Shapey J....Kaye A.H.	2011
20	Neovascular glaucoma following stereotactic radiosurgery for an optic nerve glioma: a case report. ( 20714392 )	Jeon S...Park CK	2010
21	Diagnostic pitfall: optic neuritis mimicking optic nerve glioma. ( 18721230 )	Bergmann M....Probst-Cousin S.	2009
22	Optic nerve sheath fenestration for an isolated optic nerve glioma. ( 18930671 )		2009
23	Multiple wedge-shaped retinal nerve fiber layer defects in a patient with optic nerve glioma in the contralateral eye: case report. ( 19820802 )		2009
24	Electrophysiological monitoring in a patient with an optic nerve glioma. ( 18301934 )	Moradi P....Holder G.E.	2008
25	Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm. ( 19033845 )	Walrath J.D....Kazim M.	2008
26	Assessment of chemotherapeutic response in children with proptosis due to optic nerve glioma. ( 18157537 )	Diaz R.J....Bartels U.	2008
27	Adult optic nerve glioma presenting as central retinal vein occlusion. ( 25390231 )	Yatziv Y....Kesler A.	2007
28	Retrobulbar cysticercosis masquerading as optic nerve glioma. ( 17510876 )		2007
29	Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. ( 17111679 )	Hartel P.H....Nestor S.	2006
30	Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report. ( 16575300 )	Tong Z...Hashi K	2006
31	Optic nerve glioma in neurofibromatosis-I. ( 15695867 )	Maheshwari M....Gulati S.	2005
32	Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. ( 15622533 )		2005
33	Optic nerve glioma and optic neuritis mimicking one another: case report. ( 15987555 )		2005
34	Unilateral adult malignant optic nerve glioma. ( 15085353 )	Wabbels B....Lorenz B.	2004
35	Optic nerve glioma and colonic polyposis: report of a new association. ( 15384896 )	Sheta S.S....Khattab H.M.	2004
36	Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. ( 14695164 )	Bajenaru M.L....Gutmann D.H.	2003
37	Malignant optic nerve glioma: metastases to the spinal neuraxis. Case illustration. ( 12546402 )	Murphy M....Trost N.	2003
38	Optic nerve glioma in a patient with von Hippel-Lindau syndrome. ( 12580276 )	Nau J.A....Andrews D.W.	2003
39	Optic nerve glioma manifesting as intratumoral hemorrhage in a pregnant woman--case report. ( 14705324 )		2003
40	Recent advances in optic nerve glioma with a focus on the young patient. ( 14624073 )		2003
41	Optic nerve glioma. ( 12956473 )		2003
42	Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma. ( 14635617 )	Brown PD...Oncodiagosis panel, 2002 RSNA Scientific Assembly	2003
43	Optic nerve glioma. ( 11374634 )	Dewandel P....Demaerel P.	2001
44	Optic nerve glioma in infancy: a case report of the youngest patient in Thailand. ( 11529326 )		2001
45	Growth hormone hypersecretion in a girl with neurofibromatosis type 1 and an optic nerve glioma: resolution following chemotherapy. ( 11146372 )	Drake A.J....Crowne E.C.	2000
46	Bilateral optic nerve glioma. ( 10708361 )		1999
47	Choroidal neovascular membrane as a feature of optic nerve glioma. ( 9279953 )	Shields J.A....Milner R.S.	1997
48	Optic nerve glioma mimicking an optic nerve meningioma. ( 8884101 )	Liauw L....van Duinen S.G.	1996
49	Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. ( 8607065 )	Delfini R....Cantore G.	1996
50	Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient. ( 8738366 )	Jamjoom A.B....Kolawole T.	1996

Sources

Genes for Optic Nerve Glioma

Genes related to Optic Nerve Glioma (1 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF1	Neurofibromin 1	Protein Coding	425.47	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	NES	Nestin	Protein Coding	20.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	FABP7	Fatty Acid Binding Protein 7	Protein Coding	20.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ENO2	Enolase 2	Protein Coding	20.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
6	VIM	Vimentin	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
7	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
8	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
9	S100B	S100 Calcium Binding Protein B	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
10	MBP	Myelin Basic Protein	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
11	MIB1	Mindbomb E3 Ubiquitin Protein Ligase 1	Protein Coding	15.84	DISEASES inferred ¹⁵
12	MTO1	Mitochondrial TRNA Translation Optimization 1	Protein Coding	15.38	DISEASES inferred ¹⁵
13	OPTN	Optineurin	Protein Coding	14.67	DISEASES inferred ¹⁵
14	MAP2	Microtubule Associated Protein 2	Protein Coding	14.04	DISEASES inferred ¹⁵
15	SYP	Synaptophysin	Protein Coding	13.89	DISEASES inferred ¹⁵
16	LOX	Lysyl Oxidase	Protein Coding	13.53	DISEASES inferred ¹⁵
17	TP53	Tumor Protein P53	Protein Coding	13.06	DISEASES inferred ¹⁵
18	H2AFX	H2A Histone Family Member X	Protein Coding	3.46	DISEASES inferred ¹⁵

Sources

Variations for Optic Nerve Glioma

ClinVar genetic disease variations for Optic Nerve Glioma:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	NF1	NM_000267.3(NF1): c.4267A> G (p.Lys1423Glu)	single nucleotide variant	Pathogenic	rs137854550	GRCh37	Chromosome 17, 29585518: 29585518
2	NF1	NM_000267.3(NF1): c.4267A> G (p.Lys1423Glu)	single nucleotide variant	Pathogenic	rs137854550	GRCh38	Chromosome 17, 31258500: 31258500
3	NF1	NM_000267.3(NF1): c.2041C> T (p.Arg681Ter)	single nucleotide variant	Pathogenic	rs768638173	GRCh38	Chromosome 17, 31226474: 31226474
4	NF1	NM_000267.3(NF1): c.2041C> T (p.Arg681Ter)	single nucleotide variant	Pathogenic	rs768638173	GRCh37	Chromosome 17, 29553492: 29553492
5	NF1	NM_000267.3(NF1): c.1721+3A> G	single nucleotide variant	Pathogenic	rs1057518904	GRCh38	Chromosome 17, 31221932: 31221932
6	NF1	NM_000267.3(NF1): c.1721+3A> G	single nucleotide variant	Pathogenic	rs1057518904	GRCh37	Chromosome 17, 29548950: 29548950

Cosmic variations for Optic Nerve Glioma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM476	BRAF	central nervous system,optic nerve,glioma,NS	c.1799T>A	p.V600E	7:140753336-140753336	9

Sources

Expression for Optic Nerve Glioma

Search GEO for disease gene expression data for Optic Nerve Glioma.

Sources

Pathways for Optic Nerve Glioma

Pathways related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	12.14	ENO2 FABP7 GFAP MAP2 MBP NF1
2	Interleukin-4 and 13 signaling ⁶⁶	11.55	MUC1 TP53 VIM
3	Spinal Cord Injury ¹	11.54	GFAP MBP TP53 VIM
4	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.47	GFAP NES VIM
5	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.06	FABP7 GFAP MAP2 NES S100B SYP

Sources

GO Terms for Optic Nerve Glioma

Cellular components related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell body	GO:0044297	9.13	FABP7 GFAP MAP2
2	neuronal cell body	GO:0043025	9.02	ENO2 FABP7 MAP2 MBP S100B

Biological processes related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	central nervous system development	GO:0007417	9.54	MBP NES S100B
2	intermediate filament organization	GO:0045109	9.32	GFAP VIM
3	astrocyte development	GO:0014002	9.26	GFAP VIM
4	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.16	MUC1 TP53
5	Bergmann glial cell differentiation	GO:0060020	8.96	GFAP VIM
6	intermediate filament-based process	GO:0045103	8.62	GFAP VIM

Molecular functions related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.43	GFAP OPTN S100B SYP TP53 VIM
2	structural molecule activity	GO:0005198	8.92	GFAP MAP2 NES VIM

Sources

Sources for Optic Nerve Glioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹² Disease Ontology

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia