MCID: OPT008
MIFTS: 25

Optic Nerve Neoplasm

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Neoplasm

MalaCards integrated aliases for Optic Nerve Neoplasm:

Name: Optic Nerve Neoplasm 12 15 17
Optic Nerve Neoplasms 44 70
Tumor of Second Cranial Nerve 12
Neoplasm of Optic Nerve 12
Tumour of Optic Nerve 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3419
MeSH 44 D019574
NCIt 50 C4801
SNOMED-CT 67 126968005
UMLS 70 C0524802

Summaries for Optic Nerve Neoplasm

MalaCards based summary : Optic Nerve Neoplasm, also known as optic nerve neoplasms, is related to epithelioid neurofibroma and cerebral falx meningioma. An important gene associated with Optic Nerve Neoplasm is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Glioblastoma Multiforme and Oncogenic MAPK signaling. Related phenotypes are Increased proliferation and skeleton

Related Diseases for Optic Nerve Neoplasm

Diseases related to Optic Nerve Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 epithelioid neurofibroma 10.3 NF2 NF1
2 cerebral falx meningioma 10.3 NF2 NF1
3 intraorbital meningioma 10.3 NF2 LZTR1
4 small intestine leiomyoma 10.3 NF2 NF1
5 polyp of corpus uteri 10.3 NF2 NF1
6 pediatric meningioma 10.3 NF2 KIAA1549
7 olfactory groove meningioma 10.3 NF2 LZTR1
8 anterior cranial fossa meningioma 10.3 NF2 LZTR1
9 adult malignant schwannoma 10.3 NF2 NF1
10 orbital cancer 10.3 NF2 NF1
11 mechanical ectropion 10.3 NFIC NF1
12 rete ovarii adenoma 10.3 NF2 NF1
13 optic nerve astrocytoma 10.3 SMARCB1 NF1
14 cellular neurofibroma 10.3 SMARCB1 NF1
15 monosomy 22 10.3 SMARCB1 NF2
16 rete ovarii benign neoplasm 10.3 NF2 NF1
17 juvenile pilocytic astrocytoma 10.3 NF1 KIAA1549
18 melanotic neurilemmoma 10.3 SMARCB1 NF2
19 epithelioid malignant peripheral nerve sheath tumor 10.3 SMARCB1 NF1
20 meningioma, radiation-induced 10.3 SMARCB1 NF2
21 gliofibroma 10.2 NF1 KIAA1549
22 childhood malignant schwannoma 10.2 NFIC NF1
23 adult oligodendroglioma 10.2 OLIG2 KIAA1549
24 elephantiasis 10.2 NFIC NF1
25 secretory meningioma 10.2 SMARCB1 NF2
26 spinal cord glioma 10.2 NF2 KIAA1549
27 childhood oligodendroglioma 10.2 OLIG2 KIAA1549
28 clear cell ependymoma 10.2 OLIG2 NF2
29 pylorospasm 10.2 RASA2 LZTR1
30 neurilemmoma of the fifth cranial nerve 10.2 NF2 NF1 LZTR1
31 mixed glioma 10.2 OLIG2 NF1
32 trigeminal nerve neoplasm 10.2 NF2 NF1 LZTR1
33 acoustic neuroma 10.2 NF2 NF1 LZTR1
34 clear cell meningioma 10.2 SMARCB1 NF2
35 microcystic meningioma 10.2 NF2 MIB1
36 neurofibrosarcoma 10.2 NFIC NF2 NF1
37 plexiform schwannoma 10.2 SMARCB1 NF2 NF1
38 schwannoma of twelfth cranial nerve 10.2 SMARCB1 NF2 NF1
39 hypoglossal nerve disease 10.2 SMARCB1 NF2 NF1
40 plexiform neurofibroma 10.2 NFIC NF2 NF1
41 cellular schwannoma 10.2 SMARCB1 NF2 NF1
42 corpus callosum lipoma 10.2 SMARCB1 NF2 NF1
43 cerebral hemisphere lipoma 10.2 SMARCB1 NF2 NF1
44 pineal gland cancer 10.2 SMARCB1 OLIG2
45 high grade ependymoma 10.2 NF2 KIAA1549
46 neuroma 10.2 SMARCB1 NF2 NF1
47 malignant spindle cell melanoma 10.2 RASA2 NF1
48 schwannomatosis 1 10.2 SMARCB1 NF2 LZTR1
49 neurofibromatosis 10.2 RASA2 NF2 NF1
50 neurofibroma 10.2 RASA2 NF2 NF1

Graphical network of the top 20 diseases related to Optic Nerve Neoplasm:



Diseases related to Optic Nerve Neoplasm

Symptoms & Phenotypes for Optic Nerve Neoplasm

GenomeRNAi Phenotypes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Optic Nerve Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.28 FRMD7 LZTR1 MIB1 MTOR NF1 NF2

Drugs & Therapeutics for Optic Nerve Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Fractionated CyberKnife Stereotactic Radiosurgery to Perioptic Tumors Completed NCT02225197
2 Observational Study on Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Active, not recruiting NCT02594709

Search NIH Clinical Center for Optic Nerve Neoplasm

Cochrane evidence based reviews: optic nerve neoplasms

Genetic Tests for Optic Nerve Neoplasm

Anatomical Context for Optic Nerve Neoplasm

Publications for Optic Nerve Neoplasm

Articles related to Optic Nerve Neoplasm:

# Title Authors PMID Year
1
Orbital neoplasms in adults: clinical, radiologic, and pathologic review. 61
24108560 2013
2
Optic nerve glioma and optic neuritis mimicking one another: case report. 61
15987555 2005

Variations for Optic Nerve Neoplasm

Expression for Optic Nerve Neoplasm

Search GEO for disease gene expression data for Optic Nerve Neoplasm.

Pathways for Optic Nerve Neoplasm

Pathways related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 NF2 NF1 MTOR
2
Show member pathways
11.06 RASA2 NF1 KIAA1549 FAM131B
3
Show member pathways
10.89 RASA2 NF1

GO Terms for Optic Nerve Neoplasm

Biological processes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spinal cord development GO:0021510 9.4 NF1 MTOR
2 negative regulation of MAPK cascade GO:0043409 9.37 NF2 NF1
3 positive regulation of lamellipodium assembly GO:0010592 9.32 MTOR FRMD7
4 negative regulation of Ras protein signal transduction GO:0046580 9.26 RASA2 LZTR1
5 positive regulation of oligodendrocyte differentiation GO:0048714 9.16 OLIG2 MTOR
6 regulation of GTPase activity GO:0043087 9.13 RASA2 NF1 MTOR
7 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 8.62 SMARCB1 MTOR

Sources for Optic Nerve Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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