Optic Nerve Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Optic Nerve Neoplasm

MalaCards integrated aliases for Optic Nerve Neoplasm:

Name: Optic Nerve Neoplasm ¹¹ ¹⁴ ¹⁶

Optic Nerve Neoplasms ⁴³ ⁷¹

Tumor of Second Cranial Nerve ¹¹

Neoplasm of Optic Nerve ¹¹

Tumour of Optic Nerve ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3419

MeSH ⁴³ D019574

NCIt ⁴⁹ C4801

SNOMED-CT ⁶⁸ 126968005

EFO ¹⁶ EFO_1001073

UMLS ⁷¹ C0524802

Sources

Summaries for Optic Nerve Neoplasm

MalaCards based summary: Optic Nerve Neoplasm, also known as optic nerve neoplasms, is related to epithelioid neurofibroma and neurilemmoma of the fifth cranial nerve. An important gene associated with Optic Nerve Neoplasm is NF1 (Neurofibromin 1), and among its related pathways/superpathways are RAF/MAP kinase cascade and Oncogenic MAPK signaling. The drug Midazolam has been mentioned in the context of this disorder. Related phenotypes are Increased proliferation and nervous system

Sources

Related Diseases for Optic Nerve Neoplasm

Diseases related to Optic Nerve Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)

#	Related Disease	Score	Top Affiliating Genes
1	epithelioid neurofibroma	10.3	NF2 NF1
2	neurilemmoma of the fifth cranial nerve	10.3	NF2 NF1
3	small intestine leiomyoma	10.3	NF2 NF1
4	trigeminal nerve neoplasm	10.3	NF2 NF1
5	optic nerve astrocytoma	10.3	SMARCB1 NF1
6	psammomatous meningioma	10.3	SSTR2 NF2
7	posterior pituitary gland neoplasm	10.3	SMARCB1 NF2
8	childhood meningioma	10.3	SMARCB1 NF2
9	pineal region meningioma	10.3	SMARCB1 NF2
10	cerebral falx meningioma	10.3	SMARCB1 NF2
11	parasagittal meningioma	10.3	SMARCB1 NF2
12	angiomatous meningioma	10.3	SSTR2 NF2
13	orbital cancer	10.3	NF2 NF1
14	polyp of corpus uteri	10.3	NF2 NF1
15	cerebral convexity meningioma	10.3	SMARCB1 NF2
16	schwannomatosis 1	10.3	SMARCB1 NF2
17	rete ovarii adenoma	10.3	NF2 NF1
18	olfactory groove meningioma	10.3	SMARCB1 NF2
19	cerebellopontine angle tumor	10.3	SMARCB1 NF2
20	rete ovarii benign neoplasm	10.3	NF2 NF1
21	anterior cranial fossa meningioma	10.3	SMARCB1 NF2
22	chordoid meningioma	10.3	SMARCB1 NF2
23	epithelioid malignant peripheral nerve sheath tumor	10.3	SMARCB1 NF1
24	pulsating exophthalmos	10.3	SPRED1 NF1
25	secretory meningioma	10.3	SMARCB1 NF2
26	melanotic neurilemmoma	10.3	SMARCB1 NF2
27	juvenile pilocytic astrocytoma	10.3	NF1 KIAA1549
28	rhabdoid meningioma	10.3	SMARCB1 NF2
29	clear cell ependymoma	10.3	OLIG2 NF2
30	tanycytic ependymoma	10.3	OLIG2 NF2
31	clear cell meningioma	10.3	SMARCB1 NF2
32	malignant dermis tumor	10.3	SPRED1 NF1
33	fibrous meningioma	10.3	SMARCB1 NF2
34	skin granular cell tumor	10.3	SPRED1 NF1
35	vulvar melanoma	10.3	SPRED1 NF1
36	malignant skin fibrous histiocytoma	10.3	SPRED1 NF1
37	pancreatic somatostatinoma	10.2	SST NF1
38	adult oligodendroglioma	10.2	OLIG2 KIAA1549
39	childhood oligodendroglioma	10.2	OLIG2 KIAA1549
40	anaplastic pleomorphic xanthoastrocytoma	10.2	OLIG2 KIAA1549
41	legius syndrome	10.2	SPRED1 NF1
42	perianal hematoma	10.2	SST NF1
43	solitary fibrous tumor/hemangiopericytoma	10.2	SSTR2 SMARCB1
44	duodenal somatostatinoma	10.2	SST NF1
45	idh-wildtype glioblastoma	10.2	OLIG2 NF1
46	mechanical ectropion	10.2	NFIC NF1
47	endocrine pancreas disease	10.2	SSTR2 SST
48	medulloepithelioma	10.2	SMARCB1 OLIG2
49	cellular schwannoma	10.2	SMARCB1 NF2 NF1
50	schwannoma of twelfth cranial nerve	10.2	SMARCB1 NF2 NF1

Graphical network of the top 20 diseases related to Optic Nerve Neoplasm:

Sources

Symptoms & Phenotypes for Optic Nerve Neoplasm

GenomeRNAi Phenotypes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Optic Nerve Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.02	MIB1 MTOR NF1 NF2 NFIC OLIG2
2	growth/size/body region	MP:0005378	10	LZTR1 MIB1 MTOR NF1 NF2 NFIC
3	behavior/neurological	MP:0005386	9.65	KIAA1549 MTOR NF1 NF2 NFIC OLIG2
4	craniofacial	MP:0005382	9.63	LZTR1 MIB1 NF1 NF2 NFIC SPRED1
5	skeleton	MP:0005390	9.28	LZTR1 MIB1 MTOR NF1 NF2 NFIC

Sources

Drugs & Therapeutics for Optic Nerve Neoplasm

Drugs for Optic Nerve Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Midazolam

Approved, Illicit

59467-70-8

4192

Interventional clinical trials:

#	Name	Status	NCT ID
1	A Phase II Study of Fractionated CyberKnife Stereotactic Radiosurgery to Perioptic Tumors	Completed	NCT02225197
2	Observational Study on Multisession Radiosurgery for Optic Nerve Sheath Meningiomas	Active, not recruiting	NCT02594709
3	The Effects of Endotracheal Intubation or Laryngeal Mask Applications on Optic Nerve	Not yet recruiting	NCT05445271

Search NIH Clinical Center for Optic Nerve Neoplasm

Cochrane evidence based reviews: optic nerve neoplasms

Sources

Genetic Tests for Optic Nerve Neoplasm

Sources

Anatomical Context for Optic Nerve Neoplasm

Sources

Publications for Optic Nerve Neoplasm

Articles related to Optic Nerve Neoplasm:

#	Title	Authors	PMID	Year
1	Optic nerve glioma and optic neuritis mimicking one another: case report. ⁶²	Tumialan LM...Newman NJ	15987555	2005
2	Unilateral Proptosis: Tumour of Optic Nerve. ⁶²	Martin P	19988871	1932

Sources

Genes for Optic Nerve Neoplasm

Genes related to Optic Nerve Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF1	Neurofibromin 1	Protein Coding	8.41	DISEASES inferred ¹⁴
2	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	6.8	DISEASES inferred ¹⁴
3	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	5.26	DISEASES inferred ¹⁴
4	SSTR2	Somatostatin Receptor 2	Protein Coding	5.22	DISEASES inferred ¹⁴
5	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.07	DISEASES inferred ¹⁴
6	KIAA1549	KIAA1549	Protein Coding	4.98	DISEASES inferred ¹⁴
7	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	4.64	DISEASES inferred ¹⁴
8	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	4.54	DISEASES inferred ¹⁴
9	SCARNA20	Small Cajal Body-Specific RNA 20	RNA Gene	4.54	DISEASES inferred ¹⁴
10	SST	Somatostatin	Protein Coding	4.48	DISEASES inferred ¹⁴
11	NFIC	Nuclear Factor I C	Protein Coding	4.47	DISEASES inferred ¹⁴
12	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	4.44	DISEASES inferred ¹⁴
13	FAM131B	Family With Sequence Similarity 131 Member B	Protein Coding	4.39	DISEASES inferred ¹⁴
14	BRINP3	BMP/Retinoic Acid Inducible Neural Specific 3	Protein Coding	4.31	DISEASES inferred ¹⁴
15	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	4.28	DISEASES inferred ¹⁴

Sources

Variations for Optic Nerve Neoplasm

Sources

Expression for Optic Nerve Neoplasm

Search GEO for disease gene expression data for Optic Nerve Neoplasm.

Sources

Pathways for Optic Nerve Neoplasm

Pathways related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	12.75	SPRED1 NF1 MTOR MIB1 KIAA1549 FAM131B
2	Oncogenic MAPK signaling ⁶⁶ Show member pathways Signaling by BRAF and RAF1 fusions ⁶⁶	11.1	SPRED1 NF1 KIAA1549 FAM131B
3	MECP2 and associated Rett syndrome ⁷⁴	11	SST NF1 MTOR

Sources

GO Terms for Optic Nerve Neoplasm

Biological processes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	9.97	SSTR2 SST SMARCB1 NF2 NF1
2	negative regulation of protein kinase activity	GO:0006469	9.85	SPRED1 NF2 NF1
3	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	9.71	SMARCB1 MTOR
4	negative regulation of MAPK cascade	GO:0043409	9.63	SPRED1 NF2 NF1
5	negative regulation of Schwann cell proliferation	GO:0010626	9.56	NF2 NF1
6	oligodendrocyte differentiation	GO:0048709	9.35	OLIG2 NF1 MTOR
7	Schwann cell proliferation	GO:0014010	8.92	NF2 NF1

Sources

Sources for Optic Nerve Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: OPT008 MIFTS: 27	Optic Nerve Neoplasm Categories: Cancer diseases, Eye diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Publications Drugs Expand all tables