MCID: OPT008
MIFTS: 27

Optic Nerve Neoplasm

Categories: Cancer diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Optic Nerve Neoplasm

MalaCards integrated aliases for Optic Nerve Neoplasm:

Name: Optic Nerve Neoplasm 11 14 16
Optic Nerve Neoplasms 43 71
Tumor of Second Cranial Nerve 11
Neoplasm of Optic Nerve 11
Tumour of Optic Nerve 11

Classifications:



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Disease Ontology 11 DOID:3419
MeSH 43 D019574
NCIt 49 C4801
SNOMED-CT 68 126968005
UMLS 71 C0524802

Summaries for Optic Nerve Neoplasm

MalaCards based summary: Optic Nerve Neoplasm, also known as optic nerve neoplasms, is related to epithelioid neurofibroma and neurilemmoma of the fifth cranial nerve. An important gene associated with Optic Nerve Neoplasm is NF1 (Neurofibromin 1), and among its related pathways/superpathways are RAF/MAP kinase cascade and Oncogenic MAPK signaling. The drug Midazolam has been mentioned in the context of this disorder. Related phenotypes are Increased proliferation and nervous system

Related Diseases for Optic Nerve Neoplasm

Diseases related to Optic Nerve Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 epithelioid neurofibroma 10.3 NF2 NF1
2 neurilemmoma of the fifth cranial nerve 10.3 NF2 NF1
3 small intestine leiomyoma 10.3 NF2 NF1
4 trigeminal nerve neoplasm 10.3 NF2 NF1
5 optic nerve astrocytoma 10.3 SMARCB1 NF1
6 psammomatous meningioma 10.3 SSTR2 NF2
7 posterior pituitary gland neoplasm 10.3 SMARCB1 NF2
8 childhood meningioma 10.3 SMARCB1 NF2
9 pineal region meningioma 10.3 SMARCB1 NF2
10 cerebral falx meningioma 10.3 SMARCB1 NF2
11 parasagittal meningioma 10.3 SMARCB1 NF2
12 angiomatous meningioma 10.3 SSTR2 NF2
13 orbital cancer 10.3 NF2 NF1
14 polyp of corpus uteri 10.3 NF2 NF1
15 cerebral convexity meningioma 10.3 SMARCB1 NF2
16 schwannomatosis 1 10.3 SMARCB1 NF2
17 rete ovarii adenoma 10.3 NF2 NF1
18 olfactory groove meningioma 10.3 SMARCB1 NF2
19 cerebellopontine angle tumor 10.3 SMARCB1 NF2
20 rete ovarii benign neoplasm 10.3 NF2 NF1
21 anterior cranial fossa meningioma 10.3 SMARCB1 NF2
22 chordoid meningioma 10.3 SMARCB1 NF2
23 epithelioid malignant peripheral nerve sheath tumor 10.3 SMARCB1 NF1
24 pulsating exophthalmos 10.3 SPRED1 NF1
25 secretory meningioma 10.3 SMARCB1 NF2
26 melanotic neurilemmoma 10.3 SMARCB1 NF2
27 juvenile pilocytic astrocytoma 10.3 NF1 KIAA1549
28 rhabdoid meningioma 10.3 SMARCB1 NF2
29 clear cell ependymoma 10.3 OLIG2 NF2
30 tanycytic ependymoma 10.3 OLIG2 NF2
31 clear cell meningioma 10.3 SMARCB1 NF2
32 malignant dermis tumor 10.3 SPRED1 NF1
33 fibrous meningioma 10.3 SMARCB1 NF2
34 skin granular cell tumor 10.3 SPRED1 NF1
35 vulvar melanoma 10.3 SPRED1 NF1
36 malignant skin fibrous histiocytoma 10.3 SPRED1 NF1
37 pancreatic somatostatinoma 10.2 SST NF1
38 adult oligodendroglioma 10.2 OLIG2 KIAA1549
39 childhood oligodendroglioma 10.2 OLIG2 KIAA1549
40 anaplastic pleomorphic xanthoastrocytoma 10.2 OLIG2 KIAA1549
41 legius syndrome 10.2 SPRED1 NF1
42 perianal hematoma 10.2 SST NF1
43 solitary fibrous tumor/hemangiopericytoma 10.2 SSTR2 SMARCB1
44 duodenal somatostatinoma 10.2 SST NF1
45 idh-wildtype glioblastoma 10.2 OLIG2 NF1
46 mechanical ectropion 10.2 NFIC NF1
47 endocrine pancreas disease 10.2 SSTR2 SST
48 medulloepithelioma 10.2 SMARCB1 OLIG2
49 cellular schwannoma 10.2 SMARCB1 NF2 NF1
50 schwannoma of twelfth cranial nerve 10.2 SMARCB1 NF2 NF1

Graphical network of the top 20 diseases related to Optic Nerve Neoplasm:



Diseases related to Optic Nerve Neoplasm

Symptoms & Phenotypes for Optic Nerve Neoplasm

GenomeRNAi Phenotypes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Optic Nerve Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.02 MIB1 MTOR NF1 NF2 NFIC OLIG2
2 growth/size/body region MP:0005378 10 LZTR1 MIB1 MTOR NF1 NF2 NFIC
3 behavior/neurological MP:0005386 9.65 KIAA1549 MTOR NF1 NF2 NFIC OLIG2
4 craniofacial MP:0005382 9.63 LZTR1 MIB1 NF1 NF2 NFIC SPRED1
5 skeleton MP:0005390 9.28 LZTR1 MIB1 MTOR NF1 NF2 NFIC

Drugs & Therapeutics for Optic Nerve Neoplasm

Drugs for Optic Nerve Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit 59467-70-8 4192

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Fractionated CyberKnife Stereotactic Radiosurgery to Perioptic Tumors Completed NCT02225197
2 Observational Study on Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Active, not recruiting NCT02594709
3 The Effects of Endotracheal Intubation or Laryngeal Mask Applications on Optic Nerve Not yet recruiting NCT05445271

Search NIH Clinical Center for Optic Nerve Neoplasm

Cochrane evidence based reviews: optic nerve neoplasms

Genetic Tests for Optic Nerve Neoplasm

Anatomical Context for Optic Nerve Neoplasm

Publications for Optic Nerve Neoplasm

Articles related to Optic Nerve Neoplasm:

# Title Authors PMID Year
1
Optic nerve glioma and optic neuritis mimicking one another: case report. 62
15987555 2005
2
Unilateral Proptosis: Tumour of Optic Nerve. 62
19988871 1932

Variations for Optic Nerve Neoplasm

Expression for Optic Nerve Neoplasm

Search GEO for disease gene expression data for Optic Nerve Neoplasm.

Pathways for Optic Nerve Neoplasm

Pathways related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 SPRED1 NF1 MTOR MIB1 KIAA1549 FAM131B
2
Show member pathways
11.1 SPRED1 NF1 KIAA1549 FAM131B
3 11 SST NF1 MTOR

GO Terms for Optic Nerve Neoplasm

Biological processes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 9.97 SSTR2 SST SMARCB1 NF2 NF1
2 negative regulation of protein kinase activity GO:0006469 9.85 SPRED1 NF2 NF1
3 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.71 SMARCB1 MTOR
4 negative regulation of MAPK cascade GO:0043409 9.63 SPRED1 NF2 NF1
5 negative regulation of Schwann cell proliferation GO:0010626 9.56 NF2 NF1
6 oligodendrocyte differentiation GO:0048709 9.35 OLIG2 NF1 MTOR
7 Schwann cell proliferation GO:0014010 8.92 NF2 NF1

Sources for Optic Nerve Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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