Optic Nerve Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Optic Nerve Neoplasm

MalaCards integrated aliases for Optic Nerve Neoplasm:

Name: Optic Nerve Neoplasm ¹² ¹⁵ ¹⁷

Optic Nerve Neoplasms ⁴⁴ ⁷⁰

Tumor of Second Cranial Nerve ¹²

Neoplasm of Optic Nerve ¹²

Tumour of Optic Nerve ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3419

MeSH ⁴⁴ D019574

NCIt ⁵⁰ C4801

SNOMED-CT ⁶⁷ 126968005

EFO ¹⁷ EFO_1001073

UMLS ⁷⁰ C0524802

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Summaries for Optic Nerve Neoplasm

MalaCards based summary : Optic Nerve Neoplasm, also known as optic nerve neoplasms, is related to epithelioid neurofibroma and cerebral falx meningioma. An important gene associated with Optic Nerve Neoplasm is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Glioblastoma Multiforme and Oncogenic MAPK signaling. Related phenotypes are Increased proliferation and skeleton

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Related Diseases for Optic Nerve Neoplasm

Diseases related to Optic Nerve Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score	Top Affiliating Genes
1	epithelioid neurofibroma	10.3	NF2 NF1
2	cerebral falx meningioma	10.3	NF2 NF1
3	intraorbital meningioma	10.3	NF2 LZTR1
4	small intestine leiomyoma	10.3	NF2 NF1
5	polyp of corpus uteri	10.3	NF2 NF1
6	pediatric meningioma	10.3	NF2 KIAA1549
7	olfactory groove meningioma	10.3	NF2 LZTR1
8	anterior cranial fossa meningioma	10.3	NF2 LZTR1
9	adult malignant schwannoma	10.3	NF2 NF1
10	orbital cancer	10.3	NF2 NF1
11	mechanical ectropion	10.3	NFIC NF1
12	rete ovarii adenoma	10.3	NF2 NF1
13	optic nerve astrocytoma	10.3	SMARCB1 NF1
14	cellular neurofibroma	10.3	SMARCB1 NF1
15	monosomy 22	10.3	SMARCB1 NF2
16	rete ovarii benign neoplasm	10.3	NF2 NF1
17	juvenile pilocytic astrocytoma	10.3	NF1 KIAA1549
18	melanotic neurilemmoma	10.3	SMARCB1 NF2
19	epithelioid malignant peripheral nerve sheath tumor	10.3	SMARCB1 NF1
20	meningioma, radiation-induced	10.3	SMARCB1 NF2
21	gliofibroma	10.2	NF1 KIAA1549
22	childhood malignant schwannoma	10.2	NFIC NF1
23	adult oligodendroglioma	10.2	OLIG2 KIAA1549
24	elephantiasis	10.2	NFIC NF1
25	secretory meningioma	10.2	SMARCB1 NF2
26	spinal cord glioma	10.2	NF2 KIAA1549
27	childhood oligodendroglioma	10.2	OLIG2 KIAA1549
28	clear cell ependymoma	10.2	OLIG2 NF2
29	pylorospasm	10.2	RASA2 LZTR1
30	neurilemmoma of the fifth cranial nerve	10.2	NF2 NF1 LZTR1
31	mixed glioma	10.2	OLIG2 NF1
32	trigeminal nerve neoplasm	10.2	NF2 NF1 LZTR1
33	acoustic neuroma	10.2	NF2 NF1 LZTR1
34	clear cell meningioma	10.2	SMARCB1 NF2
35	microcystic meningioma	10.2	NF2 MIB1
36	neurofibrosarcoma	10.2	NFIC NF2 NF1
37	plexiform schwannoma	10.2	SMARCB1 NF2 NF1
38	schwannoma of twelfth cranial nerve	10.2	SMARCB1 NF2 NF1
39	hypoglossal nerve disease	10.2	SMARCB1 NF2 NF1
40	plexiform neurofibroma	10.2	NFIC NF2 NF1
41	cellular schwannoma	10.2	SMARCB1 NF2 NF1
42	corpus callosum lipoma	10.2	SMARCB1 NF2 NF1
43	cerebral hemisphere lipoma	10.2	SMARCB1 NF2 NF1
44	pineal gland cancer	10.2	SMARCB1 OLIG2
45	high grade ependymoma	10.2	NF2 KIAA1549
46	neuroma	10.2	SMARCB1 NF2 NF1
47	malignant spindle cell melanoma	10.2	RASA2 NF1
48	schwannomatosis 1	10.2	SMARCB1 NF2 LZTR1
49	neurofibromatosis	10.2	RASA2 NF2 NF1
50	neurofibroma	10.2	RASA2 NF2 NF1

Graphical network of the top 20 diseases related to Optic Nerve Neoplasm:

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Symptoms & Phenotypes for Optic Nerve Neoplasm

GenomeRNAi Phenotypes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Optic Nerve Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton	MP:0005390	9.28	FRMD7 LZTR1 MIB1 MTOR NF1 NF2

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Drugs & Therapeutics for Optic Nerve Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Study of Fractionated CyberKnife Stereotactic Radiosurgery to Perioptic Tumors	Completed	NCT02225197
2	Observational Study on Multisession Radiosurgery for Optic Nerve Sheath Meningiomas	Active, not recruiting	NCT02594709

Search NIH Clinical Center for Optic Nerve Neoplasm

Cochrane evidence based reviews: optic nerve neoplasms

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Genetic Tests for Optic Nerve Neoplasm

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Anatomical Context for Optic Nerve Neoplasm

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Publications for Optic Nerve Neoplasm

Articles related to Optic Nerve Neoplasm:

#	Title	Authors	PMID	Year
1	Orbital neoplasms in adults: clinical, radiologic, and pathologic review. ⁶¹	Tailor TD...Anzai Y	24108560	2013
2	Optic nerve glioma and optic neuritis mimicking one another: case report. ⁶¹	Tumialan LM...Newman NJ	15987555	2005

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Genes for Optic Nerve Neoplasm

Genes related to Optic Nerve Neoplasm (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF1	Neurofibromin 1	Protein Coding	8.5	DISEASES inferred ¹⁵
2	NF2	Neurofibromin 2	Protein Coding	6.82	DISEASES inferred ¹⁵
3	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	5.77	DISEASES inferred ¹⁵
4	KIAA1549	KIAA1549	Protein Coding	5.28	DISEASES inferred ¹⁵
5	SCARNA20	Small Cajal Body-Specific RNA 20	RNA Gene	5.17	DISEASES inferred ¹⁵
6	NFIC	Nuclear Factor I C	Protein Coding	5.16	DISEASES inferred ¹⁵
7	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.13	DISEASES inferred ¹⁵
8	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	5.09	DISEASES inferred ¹⁵
9	RASA2	RAS P21 Protein Activator 2	Protein Coding	4.98	DISEASES inferred ¹⁵
10	FAM131B	Family With Sequence Similarity 131 Member B	Protein Coding	4.97	DISEASES inferred ¹⁵
11	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	4.91	DISEASES inferred ¹⁵
12	FRMD7	FERM Domain Containing 7	Protein Coding	4.81	DISEASES inferred ¹⁵
13	CELF6	CUGBP Elav-Like Family Member 6	Protein Coding	4.71	DISEASES inferred ¹⁵
14	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	4.71	DISEASES inferred ¹⁵

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Variations for Optic Nerve Neoplasm

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Expression for Optic Nerve Neoplasm

Search GEO for disease gene expression data for Optic Nerve Neoplasm.

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Pathways for Optic Nerve Neoplasm

Pathways related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioblastoma Multiforme ⁶³	11.18	NF2 NF1 MTOR
2	Oncogenic MAPK signaling ⁶⁵ Show member pathways Signaling by BRAF and RAF fusions ⁶⁵	11.06	RASA2 NF1 KIAA1549 FAM131B
3	G-protein signaling M-RAS regulation pathway ²³ Show member pathways G-protein signaling TC21 regulation pathway ²³ Negative feedback regulation of MAPK pathway ⁶⁵	10.89	RASA2 NF1

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GO Terms for Optic Nerve Neoplasm

Biological processes related to Optic Nerve Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	spinal cord development	GO:0021510	9.4	NF1 MTOR
2	negative regulation of MAPK cascade	GO:0043409	9.37	NF2 NF1
3	positive regulation of lamellipodium assembly	GO:0010592	9.32	MTOR FRMD7
4	negative regulation of Ras protein signal transduction	GO:0046580	9.26	RASA2 LZTR1
5	positive regulation of oligodendrocyte differentiation	GO:0048714	9.16	OLIG2 MTOR
6	regulation of GTPase activity	GO:0043087	9.13	RASA2 NF1 MTOR
7	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	8.62	SMARCB1 MTOR

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