MCID: OPT002
MIFTS: 30

Optic Nerve Sheath Meningioma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 15
Meningioma of Optic Nerve Sheath 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 50 C4538
SNOMED-CT 67 254978007
UMLS 70 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to secretory meningioma and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Optic Nerve Sheath Meningioma is NF2 (Neurofibromin 2). Affiliated tissues include eye, brain and spinal cord, and related phenotype is Increased proliferation.

Wikipedia : 73 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 32.0 SMARCB1 NF2
2 meningioma, familial 30.6 SSTR2 SMARCB1 NF2 NF1 MSN
3 intraorbital meningioma 30.5 NF2 LZTR1
4 olfactory groove meningioma 30.5 NF2 LZTR1
5 optic nerve glioma 30.5 NF2 NF1
6 acoustic neuroma 29.5 NF2 NF1 MSN LZTR1
7 neurilemmoma 29.2 SMARCB1 NF2 NF1 MSN LZTR1
8 intracranial meningioma 11.2
9 lymphoplasmacyte-rich meningioma 11.2
10 exophthalmos 10.8
11 yemenite deaf-blind hypopigmentation syndrome 10.6
12 3-methylglutaconic aciduria, type iii 10.6
13 optic nerve disease 10.6
14 neurofibromatosis 10.5
15 neuritis 10.5
16 optic neuritis 10.3
17 neuropathy 10.3
18 brain meningioma 10.3
19 intracranial hypertension 10.3
20 rare tumor 10.3
21 monosomy 22 10.3 SMARCB1 NF2
22 anterior cranial fossa meningioma 10.3 NF2 LZTR1
23 melanotic neurilemmoma 10.2 SMARCB1 NF2
24 meningioma, radiation-induced 10.2 SMARCB1 NF2
25 rhabdoid meningioma 10.2 SMARCB1 NF2
26 clear cell meningioma 10.2 SMARCB1 NF2
27 cerebral ventricle cancer 10.2 SMARCB1 NF2
28 cerebrum cancer 10.2 SMARCB1 NF2
29 supratentorial cancer 10.2 SMARCB1 NF2
30 epithelioid neurofibroma 10.2 NF2 NF1
31 microcystic meningioma 10.2 SSTR2 NF2
32 cerebral falx meningioma 10.1 NF2 NF1
33 psammomatous meningioma 10.1 SSTR2 NF2
34 small intestine leiomyoma 10.1 NF2 NF1
35 polyp of corpus uteri 10.1 NF2 NF1
36 angiomatous meningioma 10.1 SSTR2 NF2
37 adult malignant schwannoma 10.1 NF2 NF1
38 optic nerve astrocytoma 10.1 SMARCB1 NF1
39 cellular neurofibroma 10.1 SMARCB1 NF1
40 orbital cancer 10.1 NF2 NF1
41 meningothelial meningioma 10.1 SSTR2 NF2
42 rete ovarii adenoma 10.1 NF2 NF1
43 rete ovarii benign neoplasm 10.1 NF2 NF1
44 sarcoidosis 1 10.1
45 arachnoid cysts, intracranial 10.1
46 nonarteritic anterior ischemic optic neuropathy 10.1
47 human immunodeficiency virus type 1 10.1
48 igg4-related disease 10.1
49 optic papillitis 10.1
50 neuroretinitis 10.1

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


seizures; headache

GenomeRNAi Phenotypes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observational Study on Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Active, not recruiting NCT02594709

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

40
Eye, Brain, Spinal Cord, Cervix, Skeletal Muscle, Small Intestine, Pituitary

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 201)
# Title Authors PMID Year
1
Case report 68Ga-DOTATATE of optic nerve sheath meningioma. 61
33748535 2021
2
Dilation of the Perioptic Subarachnoid Space Anterior to Optic Nerve Sheath Meningioma. 61
32108115 2021
3
Gaze-evoked amaurosis from idiopathic orbital inflammation. 61
33781156 2021
4
Approach to patient with unilateral optic disc edema and normal visual function. 61
33799215 2021
5
Primary and Secondary Optic Nerve Sheath Meningioma. 61
33777618 2021
6
Prognostic Factors for Functional Outcome of Patients with Optic Nerve Sheath Meningiomas Treated with Stereotactic Radiotherapy-Evaluation of Own and Meta-Analysis of Published Data. 61
33572990 2021
7
Unilateral Isolated Paucisymptomatic Optic Disc Edema. 61
33394642 2020
8
Atypical acute presentation of an optic nerve sheath meningioma. 61
33073056 2020
9
The Coexistence of Olfactory Groove with Optic Nerve Sheath Meningioma Presenting with Anosmia: Case Report. 61
33238858 2020
10
Optic nerve sheath meningioma. 61
33009076 2020
11
Optimal management in optic nerve sheath meningioma - A multicentre study and pooled data analysis. 61
33099341 2020
12
Optic nerve sheath meningioma. 61
32897916 2020
13
Progressive sixth nerve palsy secondary to intracavernous arachnoid cyst and complicated by contralateral optic nerve sheath meningioma. 61
31155935 2020
14
The Role of Neuro-Ophthalmologists in the Care of Patients With Neurofibromatosis Type 2. 61
32796346 2020
15
Optic nerve sheath meningioma-findings in the contralateral optic nerve tract: A case report. 61
32257196 2020
16
Optical Coherence Tomography Angiography Findings in Optic Nerve Sheath Meningioma. 61
32884551 2020
17
Endoscopic orbital decompression for proptosis in non-thyroid eye disease. 61
31853760 2020
18
An Atypical Paediatric Optic Nerve Sheath Meningioma. 61
33335349 2020
19
Diosgenin inhibits the proliferation, migration and invasion of the optic nerve sheath meningioma cells via induction of mitochondrial-mediated apoptosis, autophagy and G0/G1 cell cycle arrest. 61
32277676 2020
20
Neurofibromatosis type 2 and related disorders. 61
31425178 2019
21
Efficacy of intensity-modulated radiation therapy for optic nerve sheath meningioma. 61
31377848 2019
22
Long-term treatment outcomes of patients with primary optic nerve sheath meningioma treated with stereotactic radiotherapy. 61
31401001 2019
23
Long-term efficacy of fractionated conformal radiotherapy for the management of primary optic nerve sheath meningioma. 61
30573496 2019
24
Antitumor effects of Farnesol in optic nerve sheath meningioma cell line and its effects on cell cycle progression, autophagy, cell migration and invasion. 61
31786891 2019
25
The rapid improvement in visual field defect observed with weekly perimetry during intensity-modulated radiotherapy for optic nerve sheath meningioma. 61
31218191 2019
26
Unilateral papilledema revealing an intracanalicular optic nerve sheath meningioma. 61
31312238 2019
27
Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study. 61
30812038 2019
28
Optic nerve sheath meningioma. 61
30054955 2019
29
Solitary fibrous tumor/hemangiopericytoma of the optic canal. 61
30499771 2019
30
Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma. 61
29713911 2018
31
Natural history of primary paediatric optic nerve sheath meningioma: case series and review. 61
29146762 2018
32
Teaching NeuroImages: Optic nerve sheath meningioma presenting as gaze-evoked amaurosis. 61
29866943 2018
33
Visual Outcomes and Local Control After Fractionated Stereotactic Radiotherapy for Optic Nerve Sheath Meningioma. 61
28422769 2018
34
Optic Nerve Sheath Meningioma: Preliminary Analysis of the Role of Radiation Therapy. 61
29644809 2018
35
Optic Nerve Meningioma Mimicking Cavernous Hemangioma. 61
29191527 2018
36
Rapid recovery of vision following early intervention with fractionated stereotactic radiotherapy for optic nerve sheath meningioma. 61
29430199 2018
37
The Use of 68Ga-DOTATATE PET/CT in the Non-invasive Diagnosis of Optic Nerve Sheath Meningioma: A Case Report. 61
30386741 2018
38
Retrospective chart review of the use of imaging and biopsy in the diagnosis of optic nerve sheath meningiomas and intra-conal orbital lymphomas at a single institution. 61
28812914 2017
39
Waiting to deliver a final diagnosis. 61
28131870 2017
40
Surgical Resection of an Optic Nerve Sheath Meningioma: Relevance of Endoscopic Endonasal Approaches to the Optic Canal. 61
28413768 2017
41
Diagnosis of optic nerve sheath meningioma during optic nerve sheath decompression. 61
28156180 2017
42
Somatostatin Receptor SPECT/CT using 99mTc Labeled HYNIC-TOC Aids in Diagnosis of Primary Optic Nerve Sheath Meningioma. 61
28242992 2017
43
Aneurysms Encased in Meningiomas: A Case Report and Review of the Literature. 61
26807613 2017
44
Update on the application of optic nerve sheath fenestration. 61
28339414 2017
45
Orbital melanoma with calcification: A diagnostic dilemma. 61
28112137 2016
46
Total recovery of optic nerve sheath meningioma. 61
27769976 2016
47
Cystic change in primary paediatric optic nerve sheath meningioma. 61
27310300 2016
48
An unusual radiological presentation of optic nerve sheath meningioma. 61
27330394 2016
49
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. 61
27103315 2016
50
[Visual impairment due to rare optic nerve tumor]. 61
26160104 2016

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Cellular components related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin ligase complex GO:0000151 8.92 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.62 SSTR2 SMARCB1 NF2 NF1
2 positive regulation of ubiquitin-protein transferase activity GO:0051443 9.46 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2
3 regulation of protein neddylation GO:2000434 9.43 DCUN1D5 DCUN1D3 DCUN1D2
4 negative regulation of MAPK cascade GO:0043409 9.37 NF2 NF1
5 protein neddylation GO:0045116 9.26 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2
6 positive regulation of protein neddylation GO:2000436 8.92 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2

Molecular functions related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin conjugating enzyme binding GO:0031624 9.46 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2
2 cullin family protein binding GO:0097602 9.26 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2
3 ubiquitin-like protein binding GO:0032182 8.92 DCUN1D5 DCUN1D4 DCUN1D3 DCUN1D2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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