MCID: OPT002
MIFTS: 31

Optic Nerve Sheath Meningioma

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 15
Meningioma of Optic Nerve Sheath 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 50 C4538
SNOMED-CT 68 254978007
UMLS 73 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to spinal meningioma and spinal canal and spinal cord meningioma, and has symptoms including headache and seizures. An important gene associated with Optic Nerve Sheath Meningioma is MTO1 (Mitochondrial TRNA Translation Optimization 1). Affiliated tissues include eye, lung and brain, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 76 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60–70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 10.3 NF2 SAMHD1
2 spinal canal and spinal cord meningioma 10.3 NF2 SAMHD1
3 cerebellopontine angle tumor 10.3 NF2 SAMHD1
4 benign mesothelioma 10.3 KRT5 NF2
5 meningothelial meningioma 10.2 NF2 PTGDS
6 neuritis 10.2
7 malignant essential hypertension 10.2 ACE SAMHD1
8 mitral valve insufficiency 10.1 ACE SAMHD1
9 neurofibromatosis, type ii 10.1
10 optic neuritis 10.1
11 optic nerve disease 10.1
12 neuropathy 10.1
13 malignant peritoneal mesothelioma 10.0 CDKN2A NF2
14 atypical neurofibroma 9.9 CDKN2A NF2
15 choroiditis 9.9
16 melanoma 9.9
17 adenocarcinoma 9.9
18 igg4-related disease 9.9
19 aneurysm 9.9
20 inverted transitional papilloma 9.9 CDKN2A KRT5
21 keratinizing squamous cell carcinoma 9.9 CDKN2A KRT5
22 anal canal squamous cell carcinoma 9.9 CDKN2A KRT5
23 schneiderian carcinoma 9.9 CDKN2A KRT5
24 cervical clear cell adenocarcinoma 9.9 CDKN2A KRT5
25 nasal cavity squamous cell carcinoma 9.9 CDKN2A KRT5
26 necrotizing sialometaplasia 9.8 CDKN2A KRT5
27 peritoneal mesothelioma 9.8 CDKN2A NF2
28 anus cancer 9.8 CDKN2A KRT5
29 cellular schwannoma 9.7 CDKN2A NF2
30 pre-malignant neoplasm 9.7 CDKN2A KRT5
31 in situ carcinoma 9.7 CDKN2A KRT5
32 neurofibroma 9.7 CDKN2A NF2
33 nervous system cancer 9.6 CDKN2A NF2
34 mesothelioma, malignant 9.5 CDKN2A NF2
35 pleural cancer 9.5 CDKN2A KRT5 NF2
36 malignant peripheral nerve sheath tumor 9.4 CDKN2A NF2
37 cell type cancer 9.1 CDKN2A KRT5
38 optic nerve neoplasm 7.8 ACE CDKN2A KRT5 MTO1 NF2 SCRT1

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


headache, seizures

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 PTGDS ACE CDKN2A KRT5 MTO1 NF2
2 mortality/aging MP:0010768 9.7 PTGDS SAMHD1 ACE CDKN2A KRT5 MTO1
3 neoplasm MP:0002006 9.26 PTGDS ACE CDKN2A NF2
4 no phenotypic analysis MP:0003012 8.92 PTGDS SAMHD1 CDKN2A KRT5

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

41
Eye, Lung, Brain

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 93)
# Title Authors Year
1
Teaching NeuroImages: Optic nerve sheath meningioma presenting as gaze-evoked amaurosis. ( 29866943 )
2018
2
Optic Nerve Sheath Meningioma: Preliminary Analysis of the Role of Radiation Therapy. ( 29644809 )
2018
3
Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma. ( 29713911 )
2018
4
Rapid recovery of vision following early intervention with fractionated stereotactic radiotherapy for optic nerve sheath meningioma. ( 29430199 )
2018
5
Somatostatin Receptor SPECT/CT using (99m)Tc Labeled HYNIC-TOC Aids in Diagnosis of Primary Optic Nerve Sheath Meningioma. ( 28242992 )
2017
6
Natural history of primary paediatric optic nerve sheath meningioma: case series and review. ( 29146762 )
2017
7
Surgical Resection of an Optic Nerve Sheath Meningioma: Relevance of Endoscopic Endonasal Approaches to the Optic Canal. ( 28413768 )
2017
8
Diagnosis of optic nerve sheath meningioma during optic nerve sheath decompression. ( 28156180 )
2017
9
Visual Outcomes and Local Control After Fractionated Stereotactic Radiotherapy for Optic Nerve Sheath Meningioma. ( 28422769 )
2017
10
Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma. ( 27672598 )
2016
11
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. ( 27103315 )
2016
12
Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. ( 26904329 )
2016
13
Cystic change in primary paediatric optic nerve sheath meningioma. ( 27310300 )
2016
14
Total recovery of optic nerve sheath meningioma. ( 27769976 )
2016
15
An unusual radiological presentation of optic nerve sheath meningioma. ( 27330394 )
2016
16
Pediatric primary optic nerve sheath meningioma. ( 26345328 )
2015
17
IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma. ( 26037238 )
2015
18
Optic nerve sheath meningioma: a case report with 15-year follow-up. ( 23952009 )
2014
19
A rare case of bilateral optic nerve sheath meningioma. ( 25005205 )
2014
20
Primary atypical optic nerve sheath meningioma in a child with restricted diffusion on magnetic resonance imaging. ( 24705258 )
2014
21
Unexplained loss of vision in a child: consider bilateral primary optic nerve sheath meningioma. ( 24700154 )
2014
22
Pediatric optic nerve sheath meningioma. ( 24743793 )
2014
23
Radiation optic neuropathy after proton beam therapy for optic nerve sheath meningioma. ( 23429064 )
2013
24
Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention? ( 23489873 )
2013
25
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. ( 24128652 )
2013
26
Radiation therapy for optic nerve sheath meningioma. ( 24674368 )
2013
27
Fractionated stereotactic radiotherapy in patients with optic nerve sheath meningioma. ( 21300458 )
2012
28
Fusiform appearance of optic nerve sheath meningioma: Correlating clinical and imaging findings. ( 22557880 )
2012
29
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. ( 21640493 )
2012
30
Optic nerve sheath meningioma in the first decade of life: case report and review of the literature. ( 23071466 )
2012
31
Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature. ( 21293073 )
2011
32
Long-term results of Gamma Knife surgery for optic nerve sheath meningioma. ( 21121784 )
2010
33
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma. ( 19965820 )
2010
34
Optic nerve sheath meningioma in a patient with choroidal malignant melanoma: a case report of a complex neurocristopathy. ( 19929680 )
2009
35
Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. ( 19406585 )
2009
36
Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. ( 19324384 )
2009
37
Optic nerve sheath meningioma with perioptic cyst. ( 19803105 )
2009
38
Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. ( 21369471 )
2008
39
Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. ( 19085302 )
2008
40
Successful use of mitomycin C to prevent recurrence of the cystic component of an optic nerve sheath meningioma. ( 18520847 )
2008
41
Optic nerve sheath meningioma: a case report. ( 19114016 )
2008
42
Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis. ( 18347461 )
2008
43
Primary optic nerve sheath meningioma in children. ( 19026318 )
2008
44
Radiation retinopathy after fractionated stereotactic conformal radiotherapy for primary intraorbital optic nerve sheath meningioma. ( 17549002 )
2007
45
Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. ( 17582618 )
2007
46
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. ( 17548993 )
2007
47
Optic nerve sheath meningioma: current diagnosis and treatment. ( 18004966 )
2007
48
Optic nerve sheath meningioma: visual improvement during radiation treatment. ( 16876528 )
2006
49
Cystic optic nerve sheath meningioma. ( 16845313 )
2006
50
Role for surgery as adjuvant therapy in optic nerve sheath meningioma. ( 16855500 )
2006

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 8.96 CDKN2A NF2
2 negative regulation of cell-matrix adhesion GO:0001953 8.62 CDKN2A NF2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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