MCID: OPT002
MIFTS: 32

Optic Nerve Sheath Meningioma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 15
Meningioma of Optic Nerve Sheath 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 50 C4538
UMLS 73 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to meningioma, familial and neurofibromatosis, type iv, of riccardi, and has symptoms including seizures and headache. An important gene associated with Optic Nerve Sheath Meningioma is MTO1 (Mitochondrial TRNA Translation Optimization 1), and among its related pathways/superpathways is Glioblastoma Multiforme. Affiliated tissues include eye, lung and brain, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 76 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60�??70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 30.0 CDKN2A NF2
2 neurofibromatosis, type iv, of riccardi 10.3
3 neuritis 10.3
4 spinal meningioma 10.2
5 optic neuritis 10.2
6 optic nerve disease 10.2
7 secretory meningioma 10.2
8 neuropathy 10.2
9 patulous eustachian tube 10.0
10 melanoma 10.0
11 adenocarcinoma 10.0
12 compartment syndrome 10.0
13 igg4-related disease 10.0
14 meningothelial meningioma 10.0 NF2 PTGDS
15 malignant peritoneal mesothelioma 10.0 CDKN2A NF2
16 peritoneal mesothelioma 10.0 CDKN2A NF2
17 cornea cancer 10.0 CDKN2A NF2
18 inverted transitional papilloma 10.0 CDKN2A KRT5
19 papilloma 10.0 CDKN2A KRT5
20 atypical neurofibroma 10.0 CDKN2A NF2
21 neurofibroma 9.9 CDKN2A NF2
22 keratinizing squamous cell carcinoma 9.9 CDKN2A KRT5
23 lymphoepithelioma-like thymic carcinoma 9.9 CDKN2A KRT5
24 anal canal squamous cell carcinoma 9.9 CDKN2A KRT5
25 nasal cavity squamous cell carcinoma 9.9 CDKN2A KRT5
26 necrotizing sialometaplasia 9.9 CDKN2A KRT5
27 anus cancer 9.9 CDKN2A KRT5
28 coronary restenosis 9.9 ACE CDKN2A
29 tonsil cancer 9.9 CDKN2A KRT5
30 cellular schwannoma 9.9 CDKN2A NF2
31 pre-malignant neoplasm 9.9 CDKN2A KRT5
32 oropharynx cancer 9.9 CDKN2A KRT5
33 central nervous system cancer 9.9 CDKN2A NF2
34 in situ carcinoma 9.9 CDKN2A KRT5
35 nervous system cancer 9.9 CDKN2A NF2
36 malignant peripheral nerve sheath tumor 9.9 CDKN2A NF2
37 mesothelioma, malignant 9.8 CDKN2A NF2
38 pleural cancer 9.8 CDKN2A KRT5 NF2
39 coronary heart disease 1 9.7 ACE CDKN2A
40 optic nerve neoplasm 9.3 ACE CDKN2A KRT5 MTO1 NF2 SCRT1

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


seizures, headache

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 ACE CDKN2A KRT5 MTO1 NF2 PTGDS
2 mortality/aging MP:0010768 9.43 ACE CDKN2A KRT5 MTO1 NF2 PTGDS
3 neoplasm MP:0002006 8.92 ACE CDKN2A NF2 PTGDS

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

41
Eye, Lung, Brain, Heart, Tonsil, Breast

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 95)
# Title Authors Year
1
Teaching NeuroImages: Optic nerve sheath meningioma presenting as gaze-evoked amaurosis. ( 29866943 )
2018
2
Optic Nerve Sheath Meningioma: Preliminary Analysis of the Role of Radiation Therapy. ( 29644809 )
2018
3
Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma. ( 29713911 )
2018
4
Rapid recovery of vision following early intervention with fractionated stereotactic radiotherapy for optic nerve sheath meningioma. ( 29430199 )
2018
5
Optic nerve sheath meningioma. ( 30054955 )
2018
6
The Use of 68Ga-DOTATATE PET/CT in the Non-invasive Diagnosis of Optic Nerve Sheath Meningioma: A Case Report. ( 30386741 )
2018
7
Somatostatin Receptor SPECT/CT using (99m)Tc Labeled HYNIC-TOC Aids in Diagnosis of Primary Optic Nerve Sheath Meningioma. ( 28242992 )
2017
8
Natural history of primary paediatric optic nerve sheath meningioma: case series and review. ( 29146762 )
2017
9
Surgical Resection of an Optic Nerve Sheath Meningioma: Relevance of Endoscopic Endonasal Approaches to the Optic Canal. ( 28413768 )
2017
10
Diagnosis of optic nerve sheath meningioma during optic nerve sheath decompression. ( 28156180 )
2017
11
Visual Outcomes and Local Control After Fractionated Stereotactic Radiotherapy for Optic Nerve Sheath Meningioma. ( 28422769 )
2017
12
Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma. ( 27672598 )
2016
13
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. ( 27103315 )
2016
14
Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. ( 26904329 )
2016
15
Cystic change in primary paediatric optic nerve sheath meningioma. ( 27310300 )
2016
16
Total recovery of optic nerve sheath meningioma. ( 27769976 )
2016
17
An unusual radiological presentation of optic nerve sheath meningioma. ( 27330394 )
2016
18
Pediatric primary optic nerve sheath meningioma. ( 26345328 )
2015
19
IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma. ( 26037238 )
2015
20
Optic nerve sheath meningioma: a case report with 15-year follow-up. ( 23952009 )
2014
21
A rare case of bilateral optic nerve sheath meningioma. ( 25005205 )
2014
22
Primary atypical optic nerve sheath meningioma in a child with restricted diffusion on magnetic resonance imaging. ( 24705258 )
2014
23
Unexplained loss of vision in a child: consider bilateral primary optic nerve sheath meningioma. ( 24700154 )
2014
24
Pediatric optic nerve sheath meningioma. ( 24743793 )
2014
25
Radiation optic neuropathy after proton beam therapy for optic nerve sheath meningioma. ( 23429064 )
2013
26
Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention? ( 23489873 )
2013
27
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. ( 24128652 )
2013
28
Radiation therapy for optic nerve sheath meningioma. ( 24674368 )
2013
29
Fractionated stereotactic radiotherapy in patients with optic nerve sheath meningioma. ( 21300458 )
2012
30
Fusiform appearance of optic nerve sheath meningioma: Correlating clinical and imaging findings. ( 22557880 )
2012
31
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. ( 21640493 )
2012
32
Optic nerve sheath meningioma in the first decade of life: case report and review of the literature. ( 23071466 )
2012
33
Prolonged vision return after radiosurgery for an optic nerve-sheath meningioma. ( 29296344 )
2012
34
Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature. ( 21293073 )
2011
35
Long-term results of Gamma Knife surgery for optic nerve sheath meningioma. ( 21121784 )
2010
36
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma. ( 19965820 )
2010
37
Optic nerve sheath meningioma in a patient with choroidal malignant melanoma: a case report of a complex neurocristopathy. ( 19929680 )
2009
38
Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. ( 19406585 )
2009
39
Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. ( 19324384 )
2009
40
Optic nerve sheath meningioma with perioptic cyst. ( 19803105 )
2009
41
Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. ( 21369471 )
2008
42
Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. ( 19085302 )
2008
43
Successful use of mitomycin C to prevent recurrence of the cystic component of an optic nerve sheath meningioma. ( 18520847 )
2008
44
Optic nerve sheath meningioma: a case report. ( 19114016 )
2008
45
Primary optic nerve sheath meningioma in children. ( 19026318 )
2008
46
Radiation retinopathy after fractionated stereotactic conformal radiotherapy for primary intraorbital optic nerve sheath meningioma. ( 17549002 )
2007
47
Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. ( 17582618 )
2007
48
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. ( 17548993 )
2007
49
Optic nerve sheath meningioma: current diagnosis and treatment. ( 18004966 )
2007
50
Optic nerve compartment syndrome in a patient with optic nerve sheath meningioma. ( 17534836 )
2007

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

Pathways related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 CDKN2A NF2

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.16 CDKN2A NF2
2 regulation of protein stability GO:0031647 8.96 CDKN2A NF2
3 negative regulation of cell-matrix adhesion GO:0001953 8.62 CDKN2A NF2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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