MCID: OPT002
MIFTS: 30

Optic Nerve Sheath Meningioma

Categories: Cancer diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 11 14 75
Meningioma of Optic Nerve Sheath 11 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5632
NCIt 49 C4538
SNOMED-CT 68 254978007
UMLS 71 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary: Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to orbital cancer and optic nerve glioma, and has symptoms including headache and seizures. An important gene associated with Optic Nerve Sheath Meningioma is NF2 (NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor). Affiliated tissues include eye, cervix and breast, and related phenotypes are Increased proliferation and growth/size/body region

Wikipedia: 75 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 orbital cancer 30.7 NF2 NF1
2 optic nerve glioma 30.7 NF2 NF1
3 neurofibromatosis 30.1 SMARCB1 NF2 NF1 MSN LZTR1
4 meningioma, familial 30.1 TRAF7 SSTR2 SST SMARCB1 NF2 NF1
5 olfactory groove meningioma 30.0 TRAF7 SMARCB1 NF2
6 acoustic neuroma 30.0 SMARCB1 NF2 NF1 MSN LZTR1
7 neurilemmoma 29.6 SMARCB1 NF2 NF1 MSN LZTR1
8 neurofibromatosis, type ii 29.5 TRAF7 SMARCB1 NF2 NF1 MSN LZTR1
9 intracranial meningioma 29.1 TRAF7 SSTR2 SST SMARCB1 NF2 NF1
10 3-methylglutaconic aciduria, type iii 10.7
11 optic nerve disease 10.6
12 neuritis 10.5
13 optic neuritis 10.4
14 neuropathy 10.3
15 nonarteritic anterior ischemic optic neuropathy 10.3
16 acute retrobulbar neuritis 10.3
17 intracranial hypertension 10.3
18 rare tumor 10.3
19 posterior pituitary gland neoplasm 10.2 SMARCB1 NF2
20 pineal region meningioma 10.2 SMARCB1 NF2
21 schwannomatosis 1 10.2 SMARCB1 NF2
22 cerebellopontine angle tumor 10.2 SMARCB1 NF2
23 epithelioid neurofibroma 10.2 NF2 NF1
24 neurilemmoma of the fifth cranial nerve 10.2 NF2 NF1
25 melanotic neurilemmoma 10.2 SMARCB1 NF2
26 small intestine leiomyoma 10.2 NF2 NF1
27 trigeminal nerve neoplasm 10.2 NF2 NF1
28 spinal cord astrocytoma 10.2 NF2 NF1
29 spinal cord ependymoma 10.2 SMARCB1 NF2
30 epidural spinal canal neoplasm 10.2 NF2 NF1
31 polyp of corpus uteri 10.2 NF2 NF1
32 rete ovarii adenoma 10.2 NF2 NF1
33 rete ovarii benign neoplasm 10.2 NF2 NF1
34 anaplastic ependymoma 10.2 SMARCB1 NF2
35 optic nerve astrocytoma 10.2 SMARCB1 NF1
36 spinal cord glioma 10.2 NF2 NF1
37 endocrine pancreas disease 10.2 SSTR2 SST
38 carcinoid tumors, intestinal 10.2 SSTR2 SST
39 neurofibrosarcoma 10.2 NF2 NF1
40 high grade ependymoma 10.2 SMARCB1 NF2
41 obstructive hydrocephalus 10.2 NF2 NF1
42 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 NF1
43 cerebellopontine angle meningioma 10.2 TMEM30B NF2
44 gastrointestinal neuroendocrine tumor 10.1 SSTR2 SST
45 cerebral ventricle cancer 10.1 SMARCB1 NF2
46 benign ependymoma 10.1 NF2 NF1
47 pulmonary neuroendocrine tumor 10.1 SSTR2 SST
48 esophageal neuroendocrine tumor 10.1 SSTR2 SST
49 cerebrum cancer 10.1 SMARCB1 NF2
50 pancreatic endocrine carcinoma 10.1 SSTR2 SST

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


headache; seizures

GenomeRNAi Phenotypes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 DCUN1D3 LZTR1 MSN NF1 NF2 SMARCB1
2 vision/eye MP:0005391 9.1 MSN NF1 NF2 SMARCB1 SSTR2 TMEM30B

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Search Clinical Trials, NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

Organs/tissues related to Optic Nerve Sheath Meningioma:

MalaCards : Eye, Cervix, Breast, Lung, Thyroid, Brain

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 221)
# Title Authors PMID Year
1
Optic Nerve Sheath Meningioma Presenting as a Slow-Growing Intraocular Mass. 62
36255082 2022
2
Gaze-evoked amaurosis from idiopathic orbital inflammation. 62
33781156 2022
3
Does Endoscopic Transnasal Optic Nerve Decompression Followed by Radiosurgery Improve Outcomes in the Treatment of Parasellar Meningiomas? 62
36013604 2022
4
Investigating the number of radiation fields in intensity-modulated radiotherapy plans of optic nerve sheath meningioma patients using dose gradient index. 62
35321959 2022
5
Peripapillary choroidal neovascularization associated with optic nerve sheath meningioma. 62
36248086 2022
6
TRAF7 somatic mosaicism in a patient with bilateral optic nerve sheath meningiomas: illustrative case. 62
35733823 2022
7
Imaging Findings of Pediatric Orbital Masses and Tumor Mimics. 62
35245105 2022
8
Characteristics of peripapillary retinal nerve fiber layer atrophy in glaucoma, optic nerve sheath meningioma, and sphenoid wing meningioma. 62
34554296 2022
9
[Results of radiation therapy for optic nerve sheath meningioma]. 62
36288412 2022
10
Long-Term Visual Function After Fractionated Stereotactic Radiotherapy for Primary Optic Nerve Sheath Meningioma: A Retrospective Analysis of 34 Subjects. 62
36172493 2022
11
Somatostatin receptor PET/CT scan as a helpful diagnostic tool for optic nerve sheath meningioma. 62
34229893 2021
12
Unilateral Isolated Paucisymptomatic Optic Disc Edema. 62
33394642 2021
13
Radiotherapy for the treatment of optic nerve sheath meningioma: A systematic review and meta-analysis. 62
34688809 2021
14
Uncovering an Optic Nerve Sheath Meningioma Using 68Ga-DOTATATE PET/CT. 62
33826577 2021
15
Treatment of Recurrent Optic Nerve Sheath Meningioma With a Secondary Course of Radiotherapy. 62
34660125 2021
16
Salvage Radiosurgery for Optic Nerve Sheath Meningioma. 62
34422481 2021
17
68Ga-DOTATOC-PET/MRI-A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma. 62
34282752 2021
18
Case report 68Ga-DOTATATE of optic nerve sheath meningioma. 62
33748535 2021
19
Bilateral calcification of the optic nerve sheath: A diagnostic dilemma. 62
33997471 2021
20
Incipient Non-Arteritic Anterior Ischemic Optic Neuropathy in a Patient with Metastatic Small-Cell Lung Cancer. 62
34248584 2021
21
Approach to patient with unilateral optic disc edema and normal visual function. 62
33799215 2021
22
Surgical Treatment of Bilateral Optic Nerve Sheath Meningioma: 2-Dimensional Operative Video. 62
33940610 2021
23
Dilation of the Perioptic Subarachnoid Space Anterior to Optic Nerve Sheath Meningioma. 62
32108115 2021
24
Primary and Secondary Optic Nerve Sheath Meningioma. 62
33777618 2021
25
The Coexistence of Olfactory Groove with Optic Nerve Sheath Meningioma Presenting with Anosmia: A Case Report. 62
33238858 2021
26
Efficacy and Safety of Proton Beam Therapy for Primary Optic Nerve Sheath Meningioma. 62
34466049 2021
27
Neuroimaging Features of Optic Nerve Hemangioblastoma Identified by Conventional and Advanced Magnetic Resonance Techniques: A Case Report and Literature Review. 62
34868983 2021
28
Prognostic Factors for Functional Outcome of Patients with Optic Nerve Sheath Meningiomas Treated with Stereotactic Radiotherapy-Evaluation of Own and Meta-Analysis of Published Data. 62
33572990 2021
29
Atypical acute presentation of an optic nerve sheath meningioma. 62
33073056 2020
30
Optic nerve sheath meningioma. 62
33009076 2020
31
Optimal management in optic nerve sheath meningioma - A multicentre study and pooled data analysis. 62
33099341 2020
32
Progressive sixth nerve palsy secondary to intracavernous arachnoid cyst and complicated by contralateral optic nerve sheath meningioma. 62
31155935 2020
33
The Role of Neuro-Ophthalmologists in the Care of Patients With Neurofibromatosis Type 2. 62
32796346 2020
34
Optical Coherence Tomography Angiography Findings in Optic Nerve Sheath Meningioma. 62
32884551 2020
35
Optic nerve sheath meningioma-findings in the contralateral optic nerve tract: A case report. 62
32257196 2020
36
Endoscopic orbital decompression for proptosis in non-thyroid eye disease. 62
31853760 2020
37
Diosgenin inhibits the proliferation, migration and invasion of the optic nerve sheath meningioma cells via induction of mitochondrial-mediated apoptosis, autophagy and G0/G1 cell cycle arrest. 62
32277676 2020
38
Optic nerve sheath meningioma endoscopic endonasal surgical management. 62
36329720 2020
39
An Atypical Paediatric Optic Nerve Sheath Meningioma. 62
33335349 2020
40
Neurofibromatosis type 2 and related disorders. 62
31425178 2019
41
Long-term efficacy of fractionated conformal radiotherapy for the management of primary optic nerve sheath meningioma. 62
30573496 2019
42
Long-term treatment outcomes of patients with primary optic nerve sheath meningioma treated with stereotactic radiotherapy. 62
31401001 2019
43
Efficacy of intensity-modulated radiation therapy for optic nerve sheath meningioma. 62
31377848 2019
44
Antitumor effects of Farnesol in optic nerve sheath meningioma cell line and its effects on cell cycle progression, autophagy, cell migration and invasion. 62
31786891 2019
45
The rapid improvement in visual field defect observed with weekly perimetry during intensity-modulated radiotherapy for optic nerve sheath meningioma. 62
31218191 2019
46
Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study. 62
30812038 2019
47
Unilateral papilledema revealing an intracanalicular optic nerve sheath meningioma. 62
31312238 2019
48
Optic nerve sheath meningioma. 62
30054955 2019
49
Solitary fibrous tumor/hemangiopericytoma of the optic canal. 62
30499771 2019
50
Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma. 62
29713911 2018

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 9.61 SSTR2 SST SMARCB1 NF2 NF1
2 negative regulation of cell-matrix adhesion GO:0001953 9.56 NF2 NF1
3 negative regulation of Ras protein signal transduction GO:0046580 9.5 NF1 LZTR1
4 negative regulation of Schwann cell proliferation GO:0010626 9.46 NF2 NF1
5 Schwann cell proliferation GO:0014010 8.92 NF2 NF1

Sources for Optic Nerve Sheath Meningioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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