Optic Neuritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OPT009 MIFTS: 53	Optic Neuritis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Optic Neuritis

MalaCards integrated aliases for Optic Neuritis:

Name: Optic Neuritis ¹² ⁷⁶ ⁵³ ³⁷ ⁵⁵ ⁶ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of optic nerve and visual pathways

Optic neuritis

External Ids:

Disease Ontology ¹² DOID:1210

ICD10 ³³ H46 H46.9

ICD9CM ³⁵ 377.3 377.30

MeSH ⁴⁴ D009902

NCIt ⁵⁰ C84950

SNOMED-CT ⁶⁸ 66760008

KEGG ³⁷ H01717

UMLS ⁷³ C0029134

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Summaries for Optic Neuritis

NIH Rare Diseases : ⁵³ Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. The condition may cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

MalaCards based summary : Optic Neuritis is related to autoimmune optic neuritis and neuromyelitis optica, and has symptoms including eye manifestations An important gene associated with Optic Neuritis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Toxoplasmosis and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dorzolamide and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are behavior/neurological and hematopoietic system

Disease Ontology : ¹² An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia : ⁷⁶ Optic neuritis is a demyelinating inflammation of the optic nerve. It is also known as optic papillitis... more...

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Related Diseases for Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)

#	Related Disease	Score	Top Affiliating Genes
1	autoimmune optic neuritis	33.6	AQP4 CNTF MBP MOG
2	neuromyelitis optica	32.9	AQP4 HLA-DRB1 MBP MOG
3	optic nerve disease	32.4	AQP4 MBP MOG MT-ND4
4	neuritis	31.3	AQP4 MAG MBP MOG MPZ TNF
5	myelitis	30.8	AQP4 MBP MOG TNF
6	encephalitis	30.7	AQP4 CCR5 MOG
7	transverse myelitis	30.7	AQP4 MBP TNF
8	allergic encephalomyelitis	30.4	MBP MOG PLP1
9	panencephalitis, subacute sclerosing	30.3	MBP MOG
10	relapsing-remitting multiple sclerosis	30.3	AQP4 MBP MOG TNF
11	neuroretinitis	30.3	AQP4 MOG
12	cytomegalovirus retinitis	30.3	CCR5 TNF
13	rubella	30.2	HLA-DRB1 MOG TNF
14	acute disseminated encephalomyelitis	30.1	AQP4 HLA-DRB1 MBP MOG MPZ
15	demyelinating disease	30.1	AQP4 MAG MBP MOG PLP1 TNF
16	miller fisher syndrome	30.1	MAG TNF
17	pediatric multiple sclerosis	30.0	HLA-DRB1 MOG
18	panuveitis	30.0	HLA-DRB1 TNF
19	polyneuropathy	29.9	MAG MBP MPZ
20	oligoarticular juvenile idiopathic arthritis	29.8	CCR5 HLA-DRB1 TNF
21	guillain-barre syndrome	29.8	MBP MPZ TNF
22	chronic inflammatory demyelinating polyradiculoneuropathy	29.7	HLA-DRB1 MPZ
23	psoriatic arthritis	29.6	HLA-DRB1 LTA TNF
24	multiple sclerosis	29.5	AQP4 CCR5 CNTF HLA-DRB1 LTA MAG
25	polyradiculoneuropathy	29.3	HLA-DRB1 MAG MBP MPZ
26	charcot-marie-tooth disease	29.0	CNTF MAG MBP MPZ PLP1
27	isolated optic neuritis	12.4
28	chronic relapsing inflammatory optic neuropathy	11.9
29	neuropathy	10.5
30	neuromyelitis optica spectrum disorder	10.5
31	ischemic optic neuropathy	10.4
32	systemic lupus erythematosus	10.3
33	lupus erythematosus	10.3
34	hepatitis	10.3
35	retinitis	10.3
36	alexia	10.2	AQP4 MBP
37	nonarteritic anterior ischemic optic neuropathy	10.2
38	uveitis	10.2
39	narcolepsy 1	10.2	HLA-DRB1 MOG
40	microscopic polyangiitis	10.2	HLA-DRB1 TNF
41	beryllium disease	10.2	HLA-DRB1 TNF
42	chronic beryllium disease	10.2	HLA-DRB1 TNF
43	influenza	10.2
44	anca-associated vasculitis	10.2	HLA-DRB1 TNF
45	actinic prurigo	10.2	HLA-DRB1 TNF
46	microscopic colitis	10.2	HLA-DRB1 TNF
47	nontuberculous mycobacterial lung disease	10.2	HLA-DRB1 TNF
48	central nervous system vasculitis	10.2	HLA-DRB1 TNF
49	rheumatoid vasculitis	10.2	HLA-DRB1 TNF
50	chickenpox	10.2

Comorbidity relations with Optic Neuritis via Phenotypic Disease Network (PDN):

Hypertension, Essential

Temporal Arteritis

Graphical network of the top 20 diseases related to Optic Neuritis:

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Symptoms & Phenotypes for Optic Neuritis

UMLS symptoms related to Optic Neuritis:

eye manifestations

MGI Mouse Phenotypes related to Optic Neuritis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.07	AQP4 CCR5 CNTF LTA MAG MBP
2	hematopoietic system	MP:0005397	10.02	AQP4 CCR5 CNTF LTA MAG MBP
3	homeostasis/metabolism	MP:0005376	9.96	AQP4 CCR5 CNTF LTA MAG MBP
4	immune system	MP:0005387	9.9	AQP4 CCR5 CNTF LTA MAG MBP
5	nervous system	MP:0003631	9.65	AQP4 CCR5 CNTF LTA MAG MBP
6	vision/eye	MP:0005391	9.17	AQP4 CCR5 LTA MBP MOG PLP1

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Drugs & Therapeutics for Optic Neuritis

Drugs for Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dorzolamide

Approved

Phase 4,Not Applicable

120279-96-1

5284549 3154

Timolol

Approved

Phase 4,Phase 3,Phase 1,Not Applicable

26839-75-8

33624 5478

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

53-03-2

5865

Mycophenolic acid

Approved

Phase 4

24280-93-1

446541

Mitoxantrone

Approved, Investigational

Phase 4

65271-80-9

4212

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

Bevacizumab

Approved, Investigational

Phase 4,Phase 2,Phase 1,Early Phase 1

216974-75-3

Methotrexate

Approved

Phase 4

59-05-2, 1959-05-2

126941

4-Aminopyridine

Approved

Phase 4,Phase 2,Phase 3

504-24-5

1727

Levodopa

Approved

Phase 4

59-92-7

6047

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Carbidopa

Approved

Phase 4

28860-95-9

34359 38101

Interferon beta-1a

Approved, Investigational

Phase 4,Phase 3

145258-61-3

6438354

Methimazole

Approved

Phase 4

60-56-0

1349907

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Metoprolol

Approved, Investigational

Phase 4

37350-58-6, 51384-51-1

4171

Propranolol

Approved, Investigational

Phase 4

525-66-6

4946

Amiodarone

Approved, Investigational

Phase 4

1951-25-3

2157

Interferon beta-1b

Approved

Phase 4,Phase 2,Phase 3

145155-23-3

Idebenone

Approved, Investigational

Phase 4,Phase 3,Phase 2

58186-27-9

Linezolid

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

165800-03-3

441401

Tadalafil

Approved, Investigational

Phase 4

171596-29-5

110635

leucovorin

Approved

Phase 4

58-05-9

6006 143

Ciprofloxacin

Approved, Investigational

Phase 4

85721-33-1

2764

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Azithromycin

Approved

Phase 4

83905-01-5

55185 447043

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 1

59-30-3

6037

Choline

Approved, Nutraceutical

Phase 4,Not Applicable

62-49-7

305

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2920-86-7

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1

Adjuvants, Immunologic

Phase 4,Phase 3,Phase 2,Not Applicable

Glatiramer Acetate

Phase 4,Phase 3,Phase 2

147245-92-9

3081884

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1

Anti-Arrhythmia Agents

Phase 4,Phase 3,Phase 1,Not Applicable

Adrenergic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Adrenergic beta-Antagonists

Phase 4,Phase 3,Phase 1,Not Applicable

Carbonic Anhydrase Inhibitors

Phase 4,Not Applicable

Adrenergic Antagonists

Phase 4,Phase 3,Phase 1,Not Applicable

Antihypertensive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antibiotics, Antitubercular

Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 258)

#	Name	Status	NCT ID	Phase	Drugs
1	Optical Coherence Tomography: Glatiramer in Clinically Isolated Syndrome or Early Relapsing Remitting Multiple Sclerosis (MS)	Unknown status	NCT00910598	Phase 4	glatiramer acetate
2	Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients	Unknown status	NCT02053298	Phase 4	Timolol & Dorzolamide
3	Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients	Unknown status	NCT02809079	Phase 4	Mycophenolate mofetil;Prednisone
4	Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders	Unknown status	NCT02021825	Phase 4	Mitoxantrone
5	Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)	Completed	NCT03046693	Phase 4	Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
6	A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)	Completed	NCT01975324	Phase 4	dalfampridine;Placebo
7	Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy	Completed	NCT00432393	Phase 4	levodopa-carbidopa
8	Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases	Completed	NCT00404729	Phase 4	Cytidine-5’-diphosphocholine (Citicoline)
9	Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans	Completed	NCT00312325	Phase 4	Prednisolone
10	Use of Bevacizumab in Trabeculectomy Surgery	Completed	NCT01166594	Phase 4	Bevacizumab;Control
11	Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis	Completed	NCT00179478	Phase 4	interferon beta 1a 30 ug IM once weekly
12	Oral Corticotherapy in Megadoses to Treat Multiple Sclerosis During Relapse	Completed	NCT00753792	Phase 4	methylprednisolone;methylprednisolone;Placebo
13	Brimonidine vs ALTP in Progressing Human Glaucoma	Completed	NCT00466479	Phase 4	brimonidine
14	Preoperative Brimonidine on IOP of Patients Undergoing RALP	Completed	NCT02818816	Phase 4	brimonidine tartrate 0.2%
15	Liver Function After Intravenous Methylprednisolone Administration	Completed	NCT03667157	Phase 4	every week IVMP therapy;very high doses IVMP therapy
16	Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)	Completed	NCT01458600	Phase 4	Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
17	Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation	Completed	NCT01199081	Phase 4	Dronedarone
18	A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults	Completed	NCT01427309	Phase 4
19	A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease)	Completed	NCT00304291	Phase 4	Mitoxantrone
20	Follow-up Study After 11 Years of Patients Who Were Included in the BENEFIT Trial (304747) With a First Demyelinating Event Suggestive of Multiple Sclerosis	Completed	NCT01795872	Phase 4
21	A Trial of Neuroprotection With ACTH in Acute Optic Neuritis	Recruiting	NCT01838174	Phase 4	ACTHAR Gel (ACTH);IV methylprednisolone (steroids)
22	Study to Assess the Efficacy and Safety of Raxone in LHON Patients	Recruiting	NCT02774005	Phase 4	Idebenone
23	Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease	Not yet recruiting	NCT02339142	Phase 4	intravenous corticosteroids (methylprednisolone)
24	Linezolid for Treatment of Nontuberculous Mycobacterial Diseases	Not yet recruiting	NCT03220074	Phase 4	Oral Tablet
25	PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)	Terminated	NCT00867815	Phase 4	Diagnostic procedures
26	Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis	Terminated	NCT00854750	Phase 4	ACTHAR;ACTHAR;ACTHAR;ACTHAR
27	A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Treated With Natalizumab or Interferon Beta 1-a	Withdrawn	NCT00771043	Phase 4	TYSABRI and AVONEX
28	Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.	Withdrawn	NCT00037115	Phase 4	interferon beta 1a;methotrexate;methylprednisolone
29	Simvastatin Treatment of Patients With Acute Optic Neuritis	Unknown status	NCT00261326	Phase 3	simvastatin;placebo
30	Optic Neuritis Treatment Trial (ONTT)	Unknown status	NCT00000146	Phase 3	Methylprednisolone;Prednisone
31	Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy	Unknown status	NCT02439866	Phase 3	placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
32	Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION	Unknown status	NCT02329288	Phase 3	Triamcinolone Acetonide;placebo
33	Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma	Unknown status	NCT01004900	Phase 3	Travoprost/ Timolol/ Azopt/ Brimonidine
34	Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone	Unknown status	NCT00004645	Phase 3
35	Ampyra for Optic Neuritis in MS	Completed	NCT01337986	Phase 2, Phase 3	Dalfampridine/Placebo;Placebo/Dalfampridine
36	A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON). (Octagon)	Completed	NCT00856635	Phase 3	Glatiramer Acetate;placebo
37	Optic Neuritis Recovery After Oral or IV Corticosteroids	Completed	NCT01524250	Phase 2, Phase 3	corticosteroids;corticosteroids
38	Intravenous Immunoglobulin Therapy in Optic Neuritis	Completed	NCT00000117	Phase 3	Immunoglobulin
39	Ischemic Optic Neuropathy Decompression Trial (IONDT)	Completed	NCT00000127	Phase 3
40	A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)	Completed	NCT00528151	Phase 3	curcumin
41	Paraorbital-Occipital Electric Stimulation in Patients With Optic Neuropathy (BCT_optnerve)	Completed	NCT01282827	Phase 2, Phase 3
42	A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study)	Completed	NCT01892345	Phase 3	Eculizumab
43	Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049)	Completed	NCT01345240	Phase 3
44	Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients	Completed	NCT03002038	Phase 2, Phase 3	Azathioprine;Rituximab
45	Traumatic Optic Neuropathy Treatment Trial 2	Recruiting	NCT03308448	Phase 3	Recombinant human erythropoietin
46	Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)	Recruiting	NCT03547206	Phase 3	RPh201
47	Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)	Recruiting	NCT02341560	Phase 2, Phase 3	QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
48	ENDOTHELION Study Group: Effect of Bosentan in NAION Patients	Recruiting	NCT02377271	Phase 3	bosentan;placebo
49	Efficacy and Safety Study of Bilateral Intravitreal Injection of GS010 for the Treatment of Vision Loss up to 1 Year From Onset in LHON Due to the ND4 Mutation	Recruiting	NCT03293524	Phase 3	Placebo
50	A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders	Recruiting	NCT03330418	Phase 3

Search NIH Clinical Center for Optic Neuritis

Cochrane evidence based reviews: optic neuritis

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Genetic Tests for Optic Neuritis

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Anatomical Context for Optic Neuritis

MalaCards organs/tissues related to Optic Neuritis:

⁴¹

Eye, Brain, Testes, T Cells, Spinal Cord, Bone, Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Optic Neuritis:

¹⁹

Optic Nerve Which May Cause A Complete Or Partial Loss Of Vision

Sources

Publications for Optic Neuritis

Articles related to Optic Neuritis:

(show top 50) (show all 1178)

#	Title	Authors	Year
1	Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion. ( 30450148 )	Kalnins A...Iv M	2019
2	More than meets the eye: Point-of-care ultrasound diagnosis of acute optic neuritis in the emergency department. ( 30314903 )	Yee NP...Omer T	2019
3	Valuable Insights Into Visual Neuroplasticity After Optic Neuritis. ( 29297048 )	Toosy A.T.	2018
4	Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. ( 29444299 )	Stojic A....Fairless R.	2018
5	Why Therapeutic Compliance in Optic Neuritis Deserves to Be More Than Just a Footnote: Response. ( 29923869 )	Morrow M.	2018
6	Anatomical Wiring and Functional Networking Changes in the Visual System Following Optic Neuritis. ( 29297053 )	Backner Y....Levin N.	2018
7	Paediatric ADEM followed by optic neuritis: disease course, treatment response and outcome. ( 29443442 )	Wong Y.Y.M....Neuteboom R.F.	2018
8	Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. ( 29259999 )	You Y....Klistorner A.	2018
9	Association of Optic Neuritis with <i>CYP4F2</i> Gene Single Nucleotide Polymorphism and IL-17A Concentration. ( 29736281 )	Banevicius M....Liutkeviciene R.	2018
10	Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis. ( 29913164 )	Zhang Y....Yang H.	2018
11	Guillain-BarrAc syndrome and optic neuritis after Mycoplasma pneumoniae infection. ( 29429558 )	Matsunaga M....Kawano Y.	2018
12	Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. ( 29363529 )	Zhao Y....Wei S.	2018
13	Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders. ( 29802557 )	Mori S....Nakamura M.	2018
14	MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study. ( 29808469 )	Tourbah A....Arndt C.	2018
15	Clinical presentation of optic neuritis with autoantibodies anti-myelin oligodendrocyte glycoprotein. ( 29972029 )	Ducloyer J.B....Lebranchu P.	2018
16	High resolution retinal scanning reveals regional structural differences between MS and NMOSD optic neuritis regardless of antibody status. ( 29249380 )	Bertsch-Gout M....Bernard J.	2018
17	Early Diagnosis of Recurrent Optic Neuritis Using Contrast-Enhanced T2 Fluid-attenuated Inversion Recovery Imaging: a Case Report. ( 29976284 )	Li H....Chen Z.Y.	2018
18	Neuromyelitis Optica: Review and Utility of Testing Aquaporin-4 Antibody in Typical Optic Neuritis. ( 29766684 )	Seay M....Rucker J.C.	2018
19	Why Therapeutic Compliance in Optic Neuritis Deserves to be More Than Just a Footnote. ( 29901490 )		2018
20	Recurrent idiopathic neuroretinitis as a spectrum of atypical optic neuritis: a case report and literature review. ( 29538599 )		2018
21	Possible Combined Central and Peripheral Demyelination Presenting as Optic Neuritis, Cervical Myelitis, and Demyelinating Polyneuropathy with Marked Nerve Hypertrophy. ( 29540658 )		2018
22	Typical optic neuritis? ( 29941727 )		2018
23	Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. ( 29790244 )		2018
24	Differentiating Neuromyelitis Optica-Related and Multiple Sclerosis-Related Acute Optic Neuritis Using Conventional Magnetic Resonance Imaging Combined With Readout-Segmented Echo-Planar Diffusion-Weighted Imaging. ( 29787495 )		2018
25	Erratum: Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. ( 29417957 )		2018
26	MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder. ( 29670575 )		2018
27	Retinal nerve fiber layer and ganglion cell layer changes on optical coherence tomography in early multiple sclerosis and optic neuritis cases. ( 29283135 )		2018
28	Advanced diffusion-weighted imaging in patients with optic neuritis deficit - value of reduced field of view DWI and readout-segmented DWI. ( 29417865 )		2018
29	Recurrent Optic Neuritis as the Initial Symptom in Demyelinating Diseases. ( 29856159 )		2018
30	Rituximab was effective for acute disseminated encephalomyelitis followed by recurrent optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies. ( 29661590 )		2018
31	Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis. ( 29731712 )		2018
32	Time to steroid treatment in severe acute optic neuritis. ( 29931830 )		2018
33	Macular choroidal thickness and peripapillary retinal nerve fiber layer thickness in normal adults and patients with optic atrophy due to acute idiopathic demyelinating optic neuritis. ( 29856811 )		2018
34	Incidence and Causes of Overdiagnosis of Optic Neuritis. ( 29222573 )		2018
35	Diagnosis and treatment of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis. ( 29445944 )		2018
36	Clinical Characteristics of Pediatric Optic Neuritis With Myelin Oligodendrocyte Glycoprotein Seropositive: A Cohort Study. ( 29778487 )		2018
37	Exploring experimental autoimmune optic neuritis using multimodal imaging. ( 29627590 )	Manogaran P...Schippling S	2018
38	Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. ( 30075244 )	Mayer C...Fairless R	2018
39	Acute vision loss in multiple sclerosis: Optic neuritis or central serous chorioretinopathy? ( 30384200 )	Abtahi MA...Abtahi SH	2018
40	Central Nervous System Involvement in Common Variable Immunodeficiency: A Case of Acute Unilateral Optic Neuritis in a 26-Year-Old Italian Patient. ( 30555409 )	Abati E...Corti S	2018
41	Optic Nerve Cysticercosis at the Orbital Apex Presenting as Optic Neuritis. ( 30479724 )	Goel N	2018
42	Optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination: a case report. ( 30497512 )	O'Brien P...Wong RW	2018
43	Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis. ( 30417715 )	Oliveira LM...Sato DK	2018
44	Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report. ( 30509326 )	Cheung SSL...Shih KC	2018
45	Multicentric Glioblastoma Multiforme Mimicking Optic Neuritis. ( 29563957 )	Pellegrini F...Cercato C	2018
46	Recurrent optic neuritis as the only manifestation of chronic hepatitis B virus flare: a case report. ( 30326966 )	Curras-Martin D...Asif A	2018
47	Isolated optic neuritis with a concurrent abnormal trigeminal nucleus on imaging: case report of a rare complication of herpes zoster ophthalmicus. ( 30286736 )	Vanikieti K...Padungkiatsagul T	2018
48	Should Spinal MRI Be Routinely Performed in Patients With Clinically Isolated Optic Neuritis? ( 30001224 )	Meltzer E...Frohman TC	2018
49	A Case of Optic Neuritis Secondary to Lyme Disease. ( 30048578 )	Jha P...Bhandari S	2018
50	Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis. ( 29848532 )	Anandakrishnan P...Khoo TB	2018

Sources

Genes for Optic Neuritis

Genes related to Optic Neuritis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AQP4	Aquaporin 4	Protein Coding	37.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19140826 18510734 18509235 (more) 20019228 19917985
2	MBP	Myelin Basic Protein	Protein Coding	33.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7510787 7515411 7513391 (more) 7524258 8526468 7510098 7507500 7532318 9345452 7680141
3	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	33.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12732654
4	MAG	Myelin Associated Glycoprotein	Protein Coding	25.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7515411
5	PLP1	Proteolipid Protein 1	Protein Coding	25.18	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7515411 1373123 7510787 (more) 7510098 7524258
6	MT-ND4	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4	Protein Coding	23.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	LTA	Lymphotoxin Alpha	Protein Coding	23.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8624683
8	TNF	Tumor Necrosis Factor	Protein Coding	22.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	MPZ	Myelin Protein Zero	Protein Coding	21.97	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7524258 10618693 11985632
10	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CCR5	C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CNTF	Ciliary Neurotrophic Factor	Protein Coding	20.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	SOD3	Superoxide Dismutase 3	Protein Coding	20.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Optic Neuritis

ClinVar genetic disease variations for Optic Neuritis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	MT-ND4	NC_012920.1: m.11443A> C	single nucleotide variant	Uncertain significance		GRCh37	Chromosome MT, 11443: 11443
2	MT-ND4	NC_012920.1: m.11443A> C	single nucleotide variant	Uncertain significance		GRCh38	Chromosome MT, 11443: 11443

Sources

Expression for Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Sources

Pathways for Optic Neuritis

Pathways related to Optic Neuritis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	11.82	CCR5 HLA-DRB1 TNF
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.65	AQP4 PLP1 TNF
3	Cell adhesion molecules (CAMs) ³⁷	11.49	HLA-DRB1 MAG MPZ
4	Spinal Cord Injury ¹	11.34	AQP4 MAG MBP TNF
5	Cytokines and Inflammatory Response ¹	10.78	HLA-DRB1 TNF
6	Glial Cell Differentiation ¹	9.7	MAG MBP PLP1

Sources

GO Terms for Optic Neuritis

Cellular components related to Optic Neuritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.96	AQP4 CCR5 HLA-DRB1 LTA MAG MBP
2	myelin sheath	GO:0043209	9.26	MAG MBP MPZ PLP1
3	compact myelin	GO:0043218	9.16	MAG MBP
4	external side of plasma membrane	GO:0009897	9.02	AQP4 CCR5 HLA-DRB1 MOG TNF
5	membrane	GO:0016020	10.06	AQP4 CCR5 HLA-DRB1 LTA MAG MBP

Biological processes related to Optic Neuritis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.72	CCR5 HLA-DRB1 LTA MBP TNF
2	response to hypoxia	GO:0001666	9.67	LTA MT-ND4 SOD3
3	positive regulation of glial cell proliferation	GO:0060252	9.48	LTA TNF
4	negative regulation of growth of symbiont in host	GO:0044130	9.46	LTA TNF
5	cell-cell adhesion via plasma-membrane adhesion molecules	GO:0098742	9.43	MAG MPZ
6	central nervous system myelination	GO:0022010	9.4	MAG PLP1
7	astrocyte activation	GO:0048143	9.37	CNTF TNF
8	axon ensheathment	GO:0008366	9.26	MBP PLP1
9	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO:0002925	9.16	LTA TNF
10	myelination	GO:0042552	9.13	MBP MPZ PLP1
11	positive regulation of chronic inflammatory response to antigenic stimulus	GO:0002876	8.62	LTA TNF

Molecular functions related to Optic Neuritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.43	CNTF LTA TNF
2	tumor necrosis factor receptor binding	GO:0005164	9.16	LTA TNF
3	structural constituent of myelin sheath	GO:0019911	8.96	MBP PLP1
4	virus receptor activity	GO:0001618	8.8	CCR5 HLA-DRB1 MOG

Sources

Sources for Optic Neuritis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia