MCID: OPT009
MIFTS: 53

Optic Neuritis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Optic Neuritis

MalaCards integrated aliases for Optic Neuritis:

Name: Optic Neuritis 12 76 53 37 55 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1210
ICD10 33 H46 H46.9
ICD9CM 35 377.3 377.30
MeSH 44 D009902
NCIt 50 C84950
SNOMED-CT 68 66760008
KEGG 37 H01717
UMLS 73 C0029134

Summaries for Optic Neuritis

NIH Rare Diseases : 53 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. The condition may cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

MalaCards based summary : Optic Neuritis is related to autoimmune optic neuritis and neuromyelitis optica, and has symptoms including eye manifestations An important gene associated with Optic Neuritis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Toxoplasmosis and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dorzolamide and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are behavior/neurological and hematopoietic system

Disease Ontology : 12 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia : 76 Optic neuritis is a demyelinating inflammation of the optic nerve. It is also known as optic papillitis... more...

Related Diseases for Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 autoimmune optic neuritis 33.6 AQP4 CNTF MBP MOG
2 neuromyelitis optica 32.9 AQP4 HLA-DRB1 MBP MOG
3 optic nerve disease 32.4 AQP4 MBP MOG MT-ND4
4 neuritis 31.3 AQP4 MAG MBP MOG MPZ TNF
5 myelitis 30.8 AQP4 MBP MOG TNF
6 encephalitis 30.7 AQP4 CCR5 MOG
7 transverse myelitis 30.7 AQP4 MBP TNF
8 allergic encephalomyelitis 30.4 MBP MOG PLP1
9 panencephalitis, subacute sclerosing 30.3 MBP MOG
10 relapsing-remitting multiple sclerosis 30.3 AQP4 MBP MOG TNF
11 neuroretinitis 30.3 AQP4 MOG
12 cytomegalovirus retinitis 30.3 CCR5 TNF
13 rubella 30.2 HLA-DRB1 MOG TNF
14 acute disseminated encephalomyelitis 30.1 AQP4 HLA-DRB1 MBP MOG MPZ
15 demyelinating disease 30.1 AQP4 MAG MBP MOG PLP1 TNF
16 miller fisher syndrome 30.1 MAG TNF
17 pediatric multiple sclerosis 30.0 HLA-DRB1 MOG
18 panuveitis 30.0 HLA-DRB1 TNF
19 polyneuropathy 29.9 MAG MBP MPZ
20 oligoarticular juvenile idiopathic arthritis 29.8 CCR5 HLA-DRB1 TNF
21 guillain-barre syndrome 29.8 MBP MPZ TNF
22 chronic inflammatory demyelinating polyradiculoneuropathy 29.7 HLA-DRB1 MPZ
23 psoriatic arthritis 29.6 HLA-DRB1 LTA TNF
24 multiple sclerosis 29.5 AQP4 CCR5 CNTF HLA-DRB1 LTA MAG
25 polyradiculoneuropathy 29.3 HLA-DRB1 MAG MBP MPZ
26 charcot-marie-tooth disease 29.0 CNTF MAG MBP MPZ PLP1
27 isolated optic neuritis 12.4
28 chronic relapsing inflammatory optic neuropathy 11.9
29 neuropathy 10.5
30 neuromyelitis optica spectrum disorder 10.5
31 ischemic optic neuropathy 10.4
32 systemic lupus erythematosus 10.3
33 lupus erythematosus 10.3
34 hepatitis 10.3
35 retinitis 10.3
36 alexia 10.2 AQP4 MBP
37 nonarteritic anterior ischemic optic neuropathy 10.2
38 uveitis 10.2
39 narcolepsy 1 10.2 HLA-DRB1 MOG
40 microscopic polyangiitis 10.2 HLA-DRB1 TNF
41 beryllium disease 10.2 HLA-DRB1 TNF
42 chronic beryllium disease 10.2 HLA-DRB1 TNF
43 influenza 10.2
44 anca-associated vasculitis 10.2 HLA-DRB1 TNF
45 actinic prurigo 10.2 HLA-DRB1 TNF
46 microscopic colitis 10.2 HLA-DRB1 TNF
47 nontuberculous mycobacterial lung disease 10.2 HLA-DRB1 TNF
48 central nervous system vasculitis 10.2 HLA-DRB1 TNF
49 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
50 chickenpox 10.2

Comorbidity relations with Optic Neuritis via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to Optic Neuritis

Symptoms & Phenotypes for Optic Neuritis

UMLS symptoms related to Optic Neuritis:


eye manifestations

MGI Mouse Phenotypes related to Optic Neuritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 AQP4 CCR5 CNTF LTA MAG MBP
2 hematopoietic system MP:0005397 10.02 AQP4 CCR5 CNTF LTA MAG MBP
3 homeostasis/metabolism MP:0005376 9.96 AQP4 CCR5 CNTF LTA MAG MBP
4 immune system MP:0005387 9.9 AQP4 CCR5 CNTF LTA MAG MBP
5 nervous system MP:0003631 9.65 AQP4 CCR5 CNTF LTA MAG MBP
6 vision/eye MP:0005391 9.17 AQP4 CCR5 LTA MBP MOG PLP1

Drugs & Therapeutics for Optic Neuritis

Drugs for Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dorzolamide Approved Phase 4,Not Applicable 120279-96-1 5284549 3154
2
Timolol Approved Phase 4,Phase 3,Phase 1,Not Applicable 26839-75-8 33624 5478
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
6
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
10
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 216974-75-3
11
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
12
4-Aminopyridine Approved Phase 4,Phase 2,Phase 3 504-24-5 1727
13
Levodopa Approved Phase 4 59-92-7 6047
14
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
15
Carbidopa Approved Phase 4 28860-95-9 34359 38101
16
Interferon beta-1a Approved, Investigational Phase 4,Phase 3 145258-61-3 6438354
17
Methimazole Approved Phase 4 60-56-0 1349907
18
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
19
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
20
Propranolol Approved, Investigational Phase 4 525-66-6 4946
21
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
22
Interferon beta-1b Approved Phase 4,Phase 2,Phase 3 145155-23-3
23
Idebenone Approved, Investigational Phase 4,Phase 3,Phase 2 58186-27-9
24
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 165800-03-3 441401
25
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
26
leucovorin Approved Phase 4 58-05-9 6006 143
27
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
28
Ofloxacin Approved Phase 4 82419-36-1 4583
29
Azithromycin Approved Phase 4 83905-01-5 55185 447043
30
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
31
Clarithromycin Approved Phase 4 81103-11-9 84029
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
33
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
34
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
35 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
37 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
38
Glatiramer Acetate Phase 4,Phase 3,Phase 2 147245-92-9 3081884
39 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 1,Not Applicable
41 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
43 Carbonic Anhydrase Inhibitors Phase 4,Not Applicable
44 Adrenergic Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
45 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antibiotics, Antitubercular Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 258)
# Name Status NCT ID Phase Drugs
1 Optical Coherence Tomography: Glatiramer in Clinically Isolated Syndrome or Early Relapsing Remitting Multiple Sclerosis (MS) Unknown status NCT00910598 Phase 4 glatiramer acetate
2 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
3 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
4 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
5 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
6 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
7 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
8 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
9 Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans Completed NCT00312325 Phase 4 Prednisolone
10 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
11 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
12 Oral Corticotherapy in Megadoses to Treat Multiple Sclerosis During Relapse Completed NCT00753792 Phase 4 methylprednisolone;methylprednisolone;Placebo
13 Brimonidine vs ALTP in Progressing Human Glaucoma Completed NCT00466479 Phase 4 brimonidine
14 Preoperative Brimonidine on IOP of Patients Undergoing RALP Completed NCT02818816 Phase 4 brimonidine tartrate 0.2%
15 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
16 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
17 Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation Completed NCT01199081 Phase 4 Dronedarone
18 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
19 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
20 Follow-up Study After 11 Years of Patients Who Were Included in the BENEFIT Trial (304747) With a First Demyelinating Event Suggestive of Multiple Sclerosis Completed NCT01795872 Phase 4
21 A Trial of Neuroprotection With ACTH in Acute Optic Neuritis Recruiting NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV methylprednisolone (steroids)
22 Study to Assess the Efficacy and Safety of Raxone in LHON Patients Recruiting NCT02774005 Phase 4 Idebenone
23 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
24 Linezolid for Treatment of Nontuberculous Mycobacterial Diseases Not yet recruiting NCT03220074 Phase 4 Oral Tablet
25 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
26 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated NCT00854750 Phase 4 ACTHAR;ACTHAR;ACTHAR;ACTHAR
27 A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Treated With Natalizumab or Interferon Beta 1-a Withdrawn NCT00771043 Phase 4 TYSABRI and AVONEX
28 Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
29 Simvastatin Treatment of Patients With Acute Optic Neuritis Unknown status NCT00261326 Phase 3 simvastatin;placebo
30 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
31 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
32 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
33 Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Unknown status NCT01004900 Phase 3 Travoprost/ Timolol/ Azopt/ Brimonidine
34 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
35 Ampyra for Optic Neuritis in MS Completed NCT01337986 Phase 2, Phase 3 Dalfampridine/Placebo;Placebo/Dalfampridine
36 A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON). (Octagon) Completed NCT00856635 Phase 3 Glatiramer Acetate;placebo
37 Optic Neuritis Recovery After Oral or IV Corticosteroids Completed NCT01524250 Phase 2, Phase 3 corticosteroids;corticosteroids
38 Intravenous Immunoglobulin Therapy in Optic Neuritis Completed NCT00000117 Phase 3 Immunoglobulin
39 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
40 A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) Completed NCT00528151 Phase 3 curcumin
41 Paraorbital-Occipital Electric Stimulation in Patients With Optic Neuropathy (BCT_optnerve) Completed NCT01282827 Phase 2, Phase 3
42 A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study) Completed NCT01892345 Phase 3 Eculizumab
43 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
44 Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
45 Traumatic Optic Neuropathy Treatment Trial 2 Recruiting NCT03308448 Phase 3 Recombinant human erythropoietin
46 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03547206 Phase 3 RPh201
47 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
48 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
49 Efficacy and Safety Study of Bilateral Intravitreal Injection of GS010 for the Treatment of Vision Loss up to 1 Year From Onset in LHON Due to the ND4 Mutation Recruiting NCT03293524 Phase 3 Placebo
50 A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders Recruiting NCT03330418 Phase 3

Search NIH Clinical Center for Optic Neuritis

Cochrane evidence based reviews: optic neuritis

Genetic Tests for Optic Neuritis

Anatomical Context for Optic Neuritis

MalaCards organs/tissues related to Optic Neuritis:

41
Eye, Brain, Testes, T Cells, Spinal Cord, Bone, Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Optic Neuritis:

19
Optic Nerve Which May Cause A Complete Or Partial Loss Of Vision

Publications for Optic Neuritis

Articles related to Optic Neuritis:

(show top 50) (show all 1178)
# Title Authors Year
1
Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion. ( 30450148 )
2019
2
More than meets the eye: Point-of-care ultrasound diagnosis of acute optic neuritis in the emergency department. ( 30314903 )
2019
3
Valuable Insights Into Visual Neuroplasticity After Optic Neuritis. ( 29297048 )
2018
4
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. ( 29444299 )
2018
5
Why Therapeutic Compliance in Optic Neuritis Deserves to Be More Than Just a Footnote: Response. ( 29923869 )
2018
6
Anatomical Wiring and Functional Networking Changes in the Visual System Following Optic Neuritis. ( 29297053 )
2018
7
Paediatric ADEM followed by optic neuritis: disease course, treatment response and outcome. ( 29443442 )
2018
8
Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. ( 29259999 )
2018
9
Association of Optic Neuritis with <i>CYP4F2</i> Gene Single Nucleotide Polymorphism and IL-17A Concentration. ( 29736281 )
2018
10
Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis. ( 29913164 )
2018
11
Guillain-BarrAc syndrome and optic neuritis after Mycoplasma pneumoniae infection. ( 29429558 )
2018
12
Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. ( 29363529 )
2018
13
Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders. ( 29802557 )
2018
14
MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study. ( 29808469 )
2018
15
Clinical presentation of optic neuritis with autoantibodies anti-myelin oligodendrocyte glycoprotein. ( 29972029 )
2018
16
High resolution retinal scanning reveals regional structural differences between MS and NMOSD optic neuritis regardless of antibody status. ( 29249380 )
2018
17
Early Diagnosis of Recurrent Optic Neuritis Using Contrast-Enhanced T2 Fluid-attenuated Inversion Recovery Imaging: a Case Report. ( 29976284 )
2018
18
Neuromyelitis Optica: Review and Utility of Testing Aquaporin-4 Antibody in Typical Optic Neuritis. ( 29766684 )
2018
19
Why Therapeutic Compliance in Optic Neuritis Deserves to be More Than Just a Footnote. ( 29901490 )
2018
20
Recurrent idiopathic neuroretinitis as a spectrum of atypical optic neuritis: a case report and literature review. ( 29538599 )
2018
21
Possible Combined Central and Peripheral Demyelination Presenting as Optic Neuritis, Cervical Myelitis, and Demyelinating Polyneuropathy with Marked Nerve Hypertrophy. ( 29540658 )
2018
22
Typical optic neuritis? ( 29941727 )
2018
23
Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. ( 29790244 )
2018
24
Differentiating Neuromyelitis Optica-Related and Multiple Sclerosis-Related Acute Optic Neuritis Using Conventional Magnetic Resonance Imaging Combined With Readout-Segmented Echo-Planar Diffusion-Weighted Imaging. ( 29787495 )
2018
25
Erratum: Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. ( 29417957 )
2018
26
MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder. ( 29670575 )
2018
27
Retinal nerve fiber layer and ganglion cell layer changes on optical coherence tomography in early multiple sclerosis and optic neuritis cases. ( 29283135 )
2018
28
Advanced diffusion-weighted imaging in patients with optic neuritis deficit - value of reduced field of view DWI and readout-segmented DWI. ( 29417865 )
2018
29
Recurrent Optic Neuritis as the Initial Symptom in Demyelinating Diseases. ( 29856159 )
2018
30
Rituximab was effective for acute disseminated encephalomyelitis followed by recurrent optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies. ( 29661590 )
2018
31
Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis. ( 29731712 )
2018
32
Time to steroid treatment in severe acute optic neuritis. ( 29931830 )
2018
33
Macular choroidal thickness and peripapillary retinal nerve fiber layer thickness in normal adults and patients with optic atrophy due to acute idiopathic demyelinating optic neuritis. ( 29856811 )
2018
34
Incidence and Causes of Overdiagnosis of Optic Neuritis. ( 29222573 )
2018
35
Diagnosis and treatment of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis. ( 29445944 )
2018
36
Clinical Characteristics of Pediatric Optic Neuritis With Myelin Oligodendrocyte Glycoprotein Seropositive: A Cohort Study. ( 29778487 )
2018
37
Exploring experimental autoimmune optic neuritis using multimodal imaging. ( 29627590 )
2018
38
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. ( 30075244 )
2018
39
Acute vision loss in multiple sclerosis: Optic neuritis or central serous chorioretinopathy? ( 30384200 )
2018
40
Central Nervous System Involvement in Common Variable Immunodeficiency: A Case of Acute Unilateral Optic Neuritis in a 26-Year-Old Italian Patient. ( 30555409 )
2018
41
Optic Nerve Cysticercosis at the Orbital Apex Presenting as Optic Neuritis. ( 30479724 )
2018
42
Optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination: a case report. ( 30497512 )
2018
43
Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis. ( 30417715 )
2018
44
Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report. ( 30509326 )
2018
45
Multicentric Glioblastoma Multiforme Mimicking Optic Neuritis. ( 29563957 )
2018
46
Recurrent optic neuritis as the only manifestation of chronic hepatitis B virus flare: a case report. ( 30326966 )
2018
47
Isolated optic neuritis with a concurrent abnormal trigeminal nucleus on imaging: case report of a rare complication of herpes zoster ophthalmicus. ( 30286736 )
2018
48
Should Spinal MRI Be Routinely Performed in Patients With Clinically Isolated Optic Neuritis? ( 30001224 )
2018
49
A Case of Optic Neuritis Secondary to Lyme Disease. ( 30048578 )
2018
50
Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis. ( 29848532 )
2018

Variations for Optic Neuritis

ClinVar genetic disease variations for Optic Neuritis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-ND4 NC_012920.1: m.11443A> C single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 11443: 11443
2 MT-ND4 NC_012920.1: m.11443A> C single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 11443: 11443

Expression for Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Pathways for Optic Neuritis

Pathways related to Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 CCR5 HLA-DRB1 TNF
2 11.65 AQP4 PLP1 TNF
3 11.49 HLA-DRB1 MAG MPZ
4 11.34 AQP4 MAG MBP TNF
5 10.78 HLA-DRB1 TNF
6 9.7 MAG MBP PLP1

GO Terms for Optic Neuritis

Cellular components related to Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 AQP4 CCR5 HLA-DRB1 LTA MAG MBP
2 myelin sheath GO:0043209 9.26 MAG MBP MPZ PLP1
3 compact myelin GO:0043218 9.16 MAG MBP
4 external side of plasma membrane GO:0009897 9.02 AQP4 CCR5 HLA-DRB1 MOG TNF
5 membrane GO:0016020 10.06 AQP4 CCR5 HLA-DRB1 LTA MAG MBP

Biological processes related to Optic Neuritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CCR5 HLA-DRB1 LTA MBP TNF
2 response to hypoxia GO:0001666 9.67 LTA MT-ND4 SOD3
3 positive regulation of glial cell proliferation GO:0060252 9.48 LTA TNF
4 negative regulation of growth of symbiont in host GO:0044130 9.46 LTA TNF
5 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.43 MAG MPZ
6 central nervous system myelination GO:0022010 9.4 MAG PLP1
7 astrocyte activation GO:0048143 9.37 CNTF TNF
8 axon ensheathment GO:0008366 9.26 MBP PLP1
9 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.16 LTA TNF
10 myelination GO:0042552 9.13 MBP MPZ PLP1
11 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.62 LTA TNF

Molecular functions related to Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CNTF LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
3 structural constituent of myelin sheath GO:0019911 8.96 MBP PLP1
4 virus receptor activity GO:0001618 8.8 CCR5 HLA-DRB1 MOG

Sources for Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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