MCID: OPT010
MIFTS: 32

Optic Papillitis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Optic Papillitis

MalaCards integrated aliases for Optic Papillitis:

Name: Optic Papillitis 12 15
Papilledema 44 73
Papillitis 12 76

Classifications:



Summaries for Optic Papillitis

MalaCards based summary : Optic Papillitis, also known as papilledema, is related to chorioretinitis and kidney papillary necrosis, and has symptoms including edema An important gene associated with Optic Papillitis is ISCA1 (Iron-Sulfur Cluster Assembly 1). The drugs Acetazolamide and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and kidney.

Wikipedia : 76 Lingual papillae (singular papilla) are the small, nipple-like structures on the upper surface of the... more...

Related Diseases for Optic Papillitis

Graphical network of the top 20 diseases related to Optic Papillitis:



Diseases related to Optic Papillitis

Symptoms & Phenotypes for Optic Papillitis

UMLS symptoms related to Optic Papillitis:


edema

Drugs & Therapeutics for Optic Papillitis

Drugs for Optic Papillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
2
Bevacizumab Approved, Investigational Phase 4,Phase 1,Phase 2 216974-75-3
3
Ranibizumab Approved Phase 4,Phase 2 347396-82-1 459903
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
6
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
7
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
8 diuretics Phase 4,Phase 2,Phase 3
9 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
10 Anticonvulsants Phase 4,Phase 2,Phase 3
11 Natriuretic Agents Phase 4,Phase 2,Phase 3
12 Immunologic Factors Phase 4,Phase 1,Phase 2
13 Angiogenesis Inhibitors Phase 4,Phase 1,Phase 2
14 Angiogenesis Modulating Agents Phase 4,Phase 1,Phase 2
15 Endothelial Growth Factors Phase 4
16 Mitogens Phase 4
17 Pharmaceutical Solutions Phase 4,Not Applicable
18 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
19 Anti-Infective Agents Phase 4,Phase 2
20 Dermatologic Agents Phase 4
21
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
22
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
23
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
24
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
25
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
26
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
27
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
28
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
29
Warfarin Approved Phase 3 81-81-2 6691 54678486
30
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
31 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
32 glucocorticoids Phase 2, Phase 3,Phase 1
33 Hormone Antagonists Phase 2, Phase 3,Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1
35 Hormones Phase 2, Phase 3,Phase 1
36 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
37 Narcotics Phase 2, Phase 3
38 Central Nervous System Depressants Phase 2, Phase 3
39 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
41 Analgesics Phase 2, Phase 3,Not Applicable
42 Cyclooxygenase Inhibitors Phase 2, Phase 3
43 Respiratory System Agents Phase 2, Phase 3
44 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
45 Analgesics, Opioid Phase 2, Phase 3
46 Antipyretics Phase 2, Phase 3
47 Fibrinolytic Agents Phase 2, Phase 3
48 Platelet Aggregation Inhibitors Phase 2, Phase 3
49 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Not Applicable
50 Antitussive Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
2 Treatment of Diabetic Macular Edema (DME) With Anti-VEGF and Focal Laser Completed NCT03590444 Phase 4 Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
3 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
4 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
5 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
6 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
7 Surgical Idiopathic Intracranial Hypertension Treatment Trial Recruiting NCT03501966 Phase 3 Acetazolamide
8 The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis Recruiting NCT03217448 Phase 3 Dabigatran etexilate;Warfarin
9 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
10 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
11 Intravitreal Aflibercept Injection for Radiation Retinopathy Trial Recruiting NCT03085784 Phase 2 Aflibercept
12 Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Recruiting NCT03071055 Phase 2 Ranibizumab Injection [Lucentis]
13 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide
14 Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
15 Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection Terminated NCT01562132 Phase 2 Flucytosine and fluconazole;Fluconazole
16 Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis Not yet recruiting NCT03373292 Phase 1
17 aICP in Glaucoma and Papilledema Unknown status NCT02410148 Not Applicable
18 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Unknown status NCT02992262 Not Applicable
19 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858 Not Applicable
20 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481
21 Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine? Completed NCT00873613 Not Applicable
22 Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI) Completed NCT01356134
23 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Completed NCT01847638 Not Applicable Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
24 Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Completed NCT01318941 Ranibizumab
25 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179
26 Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure Recruiting NCT03178760
27 Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome Recruiting NCT02896452
28 European Increlex® (Mecasermin [rDNA Origin] Injection) Growth Forum Database - IGFD Registry Recruiting NCT00903110 Increlex®
29 Venous Sinus Stenting With the River Stent in IIH Recruiting NCT03556085 Not Applicable
30 Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases) Recruiting NCT00059748
31 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743 Not Applicable
32 Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy Recruiting NCT03490318
33 Korean Registry of Target Organ Damages in Hypertension Recruiting NCT01861080
34 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Recruiting NCT02143258 Not Applicable
35 An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH Active, not recruiting NCT02124486 Not Applicable
36 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
37 A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Available NCT01487044 Macugen (Pegaptanib Sodium)
38 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial Not yet recruiting NCT02513914 Not Applicable
39 Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography Suspended NCT03037268
40 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Optic Papillitis

Cochrane evidence based reviews: papilledema

Genetic Tests for Optic Papillitis

Anatomical Context for Optic Papillitis

MalaCards organs/tissues related to Optic Papillitis:

41
Tongue, Bone, Kidney, Brain, Heart, Eye, Bone Marrow

Publications for Optic Papillitis

Articles related to Optic Papillitis:

(show top 50) (show all 123)
# Title Authors Year
1
Myelin Oligodendrocyte Glycoprotein-IgG-positive Recurrent Bilateral Optic Papillitis with Serous Retinal Detachment: A Case Report. ( 29780155 )
2018
2
Acute pancreatitis caused by cytomegalovirus-associated duodenal papillitis. ( 29333078 )
2018
3
CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME-ASSOCIATED UVEITIS AND PAPILLITIS. ( 30134363 )
2018
4
Uveitis and Papillitis in the Setting of Dabrafenib and Trametinib Therapy for Metastatic Melanoma: A Case Report. ( 27892777 )
2018
5
Transient lingual papillitis: A retrospective study of 11 cases and review of the literature. ( 28149482 )
2017
6
SUBFOVEAL CHOROIDAL THICKNESS IN PAPILLITIS TYPE OF VOGT-KOYANAGI-HARADA DISEASE AND IDIOPATHIC OPTIC NEURITIS. ( 26509220 )
2016
7
Inflammatory Papillitis in Uveitis: Response to Treatment and Use of Optic Nerve Optical Coherence Tomography for Monitoring. ( 25549180 )
2016
8
A case of bilateral uveitis and papillitis in a patient treated with pembrolizumab. ( 26692064 )
2016
9
Goodness, gracious, great balls of fire: A case of transient lingual papillitis following consumption of an Atomic Fireball. ( 27617517 )
2016
10
Transient lingual papillitis. ( 27669723 )
2016
11
Cytomegalovirus-induced Duodenal Papillitis. ( 26134203 )
2015
12
Transient lingual papillitis associated with confirmed herpes simplex virus 1 in a patient with kawasaki disease. ( 25424222 )
2014
13
A rare case of Behçet's syndrome presenting with bilateral papillitis. ( 23952817 )
2014
14
Eruptive lingual papillitis. ( 24736927 )
2014
15
Transient filiform papillitis in a child. ( 24966652 )
2014
16
The absence of vitreous inflammation: one more challenge in diagnosing toxoplasma papillitis. ( 23576658 )
2013
17
Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection. ( 21732064 )
2012
18
Chronic lingual papulosis: new, independent entity or "mature" form of transient lingual papillitis? ( 22669070 )
2012
19
Papillitis at endoscopic retrograde cholangiopancreatography: what's the relevance? ( 22925308 )
2012
20
Unilateral papillitis, the tip of the iceberg of bilateral ICGA-detected tuberculous choroiditis. ( 21428752 )
2011
21
Paediatric Behçet's disease presenting with recurrent papillitis and episcleritis: a case report. ( 21352523 )
2011
22
Sensitive red bumps on the tongue. Transient lingual papillitis. ( 21613045 )
2011
23
Ophthalmoparesis, papillitis and premacular hemorrhage in a case with endocarditis: a rare presentation of Brucellosis. ( 20195047 )
2010
24
GD1a-associated pure motor Guillain-Barré syndrome with hyperreflexia and bilateral papillitis. ( 20215983 )
2010
25
Acute pancreatitis with CMV papillitis and cholangiopathy in a renal transplant recipient. ( 19142576 )
2009
26
Transient lingual papillitis: case reports. ( 19774866 )
2009
27
Retinal vein occlusion and papillitis in serpiginous choroidopathy. ( 25389589 )
2009
28
Interferon induced sarcoid uveitis with papillitis and macular edema. ( 25390855 )
2009
29
Cytomegalovirus papillitis in an immunocompetent patient. ( 18562845 )
2008
30
Transient lingual papillitis. ( 18610883 )
2008
31
Papillitis, Lyme disease, and cats. ( 17237753 )
2007
32
Cytomegalovirus infection in an HIV patient with duodenal papillitis. ( 17285502 )
2007
33
Irreversible papillitis and ophthalmoparesis as a presenting manifestation of neurobrucellosis. ( 17320277 )
2007
34
Cytomegalovirus infection in a liver transplant patient identified by endoscopically severe duodenal papillitis. ( 16616341 )
2006
35
An exacerbation of Behçet's syndrome presenting with bilateral papillitis. ( 15827036 )
2005
36
Distal cholangiocarcinoma associated with papillitis with viral CMV inclusions. ( 16549927 )
2005
37
Eruptive lingual papillitis with household transmission: a prospective clinical study. ( 14996101 )
2004
38
Ischemic-appearing papillitis in a patient with gallstone pancreatitis and cholangitis. ( 12741464 )
2003
39
Transient lingual papillitis: a papulokeratotic variant. ( 12931091 )
2003
40
Hemifacial atrophy (Parry-Romberg syndrome, #141300) with papillitis, retinal alterations, and restriction of motility. ( 11997811 )
2002
41
The clinical significance of papillitis of the major duodenal papilla. ( 12024144 )
2002
42
Papillitis as an onset sign of Leber's hereditary optic neuropathy: a case report. ( 11248462 )
2001
43
Adenomyomatous hyperplasia of the papilla of Vater: A sequela of chronic papillitis? ( 10359853 )
1999
44
Peripapillary subretinal neovascular complex complicating papillitis. ( 10396396 )
1999
45
Bilateral optic papillitis following mycoplasma pneumoniae pneumonia. ( 9693295 )
1998
46
Eruptive familial lingual papillitis: a new entity? ( 9050757 )
1997
47
Papillitis and vasculitis of the arteria spinalis anterior as complications of hepatitis C reinfection after liver transplantation. ( 9163866 )
1997
48
Cytomegalovirus papillitis in patients with acquired immune deficiency syndrome. Visual prognosis of patients treated with ganciclovir and/or foscarnet. ( 8841309 )
1996
49
Transient lingual papillitis. ( 8899785 )
1996
50
Papillitis: a rare initial presentation of Crohn's disease. ( 8971460 )
1996

Variations for Optic Papillitis

Expression for Optic Papillitis

Search GEO for disease gene expression data for Optic Papillitis.

Pathways for Optic Papillitis

GO Terms for Optic Papillitis

Cellular components related to Optic Papillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 8.8 CANX EXTL3 MRAP

Sources for Optic Papillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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