MCID: OPT010
MIFTS: 38

Optic Papillitis

Categories: Eye diseases, Neuronal diseases, Smell/Taste diseases

Aliases & Classifications for Optic Papillitis

MalaCards integrated aliases for Optic Papillitis:

Name: Optic Papillitis 12 15 17
Papilledema 44 70
Papillitis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10175
MeSH 44 D010211
NCIt 50 C3307
UMLS 70 C0030353 C0155288 C0242420 more

Summaries for Optic Papillitis

MalaCards based summary : Optic Papillitis, also known as papilledema, is related to syphilis and branch retinal artery occlusion, and has symptoms including edema An important gene associated with Optic Papillitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways is Visual Cycle in Retinal Rods. The drugs Isotretinoin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, eye and endothelial, and related phenotype is immune system.

Wikipedia : 73 Lingual papillae (singular papilla) are the small, nipple-like structures on the upper surface of the... more...

Related Diseases for Optic Papillitis

Diseases related to Optic Papillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.4 CRP CD4 ACE
2 branch retinal artery occlusion 30.4 CRP AQP4
3 acute retrobulbar neuritis 30.3 CRP AQP4
4 hypertensive retinopathy 30.2 CRP ACE
5 abducens nerve disease 30.2 CRP AQP4
6 choroiditis 30.0 SAG RBP3 CD4 ACE
7 chronic pyelonephritis 30.0 CRP ACE
8 retinal vasculitis 30.0 SAG RBP3 CD4 ACE
9 neuroretinitis 29.9 SAG CRP CD4 ACE
10 sarcoidosis 1 29.9 CRP CD4 ACE
11 primary syphilis 29.9 CRP CD4
12 secondary syphilis 29.8 CRP CD4
13 facial hemiatrophy 29.8 MRAP CRP
14 multiple cranial nerve palsy 29.8 CRP ACE
15 miliary tuberculosis 29.8 CRP CD4
16 granulomatous angiitis 29.8 CRP ACE
17 otitis externa 29.8 CRP CD4
18 meningitis 29.7 NLRP3 CRP AQP4
19 chorioretinitis 29.7 SAG RBP3 CRP CD4 ACE
20 pleural empyema 29.7 CRP CD4
21 syphilitic meningitis 29.7 CRP CD4
22 optic nerve disease 29.7 MOG CRP CD4 AQP4
23 actinomycosis 29.7 CRP CD4
24 demyelinating disease 29.7 MOG CD4 AQP4
25 papilledema 29.7 NLRP3 CRP CD4 AQP4 ACE
26 cryopyrin-associated periodic syndrome 29.7 NLRP3 CRP
27 hypopyon 29.6 RBP3 CRP CD4
28 cat-scratch disease 29.6 CRP CD4 ACE
29 exanthem 29.5 NLRP3 CRP CD4 ACE
30 nervous system disease 29.4 MOG CRP CD4 AQP4 ACE
31 cranial nerve palsy 29.3 CRP CD4 AQP4 ACE
32 iritis 29.3 RBP3 MRAP CRP CD4 ACE
33 eye disease 29.2 SAG RBP3 CRP CD4
34 neurosarcoidosis 29.1 MOG CRP CD4 AQP4 ACE
35 autoimmune disease 29.1 SAG RBP3 MOG CRP AQP4
36 peripheral nervous system disease 29.1 MOG CRP CD4 AQP4 ACE
37 crohn's disease 28.9 NLRP3 CRP CD4
38 iridocyclitis 28.7 TNFRSF10A RBP3 MRAP CRP CD4 ACE
39 panuveitis 28.4 TNFRSF10A SAG RBP3 MRAP CRP CD4
40 papilloma of choroid plexus 11.1
41 optic neuritis 11.1
42 kidney papillary necrosis 11.1
43 hydrocephalus 11.0
44 colloid cysts of third ventricle 10.9
45 retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome 10.9
46 rosette-forming glioneuronal tumor 10.9
47 intracranial hypertension, idiopathic 10.6
48 pseudopapilledema 10.5
49 vascular myelopathy 10.4 MOG AQP4
50 balo concentric sclerosis 10.4 MOG AQP4

Graphical network of the top 20 diseases related to Optic Papillitis:



Diseases related to Optic Papillitis

Symptoms & Phenotypes for Optic Papillitis

UMLS symptoms related to Optic Papillitis:


edema

MGI Mouse Phenotypes related to Optic Papillitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ACE AQP4 CD4 CRP MOG NLRP3

Drugs & Therapeutics for Optic Papillitis

Drugs for Optic Papillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
2
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Ranibizumab Approved Phase 4 347396-82-1 459903
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
11
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
13
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
14
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
15 Pharmaceutical Solutions Phase 4
16 Angiogenesis Inhibitors Phase 4
17 Mitogens Phase 4
18 Endothelial Growth Factors Phase 4
19 Anti-Inflammatory Agents Phase 4
20 glucocorticoids Phase 4
21 Hormone Antagonists Phase 4
22 Hormones Phase 4
23 Gastrointestinal Agents Phase 4
24 Antiemetics Phase 4
25 Methylprednisolone Acetate Phase 4
26 Antineoplastic Agents, Hormonal Phase 4
27
protease inhibitors Phase 4
28 BB 1101 Phase 4
29 HIV Protease Inhibitors Phase 4
30
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
31
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
32
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5 1986
33
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 2, Phase 3 14838-15-4 26934
34
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
35
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
36
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
37
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
38 Analgesics, Non-Narcotic Phase 2, Phase 3
39 Respiratory System Agents Phase 2, Phase 3
40 Narcotics Phase 2, Phase 3
41 Analgesics Phase 2, Phase 3
42 Fibrinolytic Agents Phase 2, Phase 3
43 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
44 Cyclooxygenase Inhibitors Phase 2, Phase 3
45 Analgesics, Opioid Phase 2, Phase 3
46 Antitussive Agents Phase 2, Phase 3
47 diuretics Phase 2, Phase 3
48 Anticonvulsants Phase 2, Phase 3
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
50 Antipyretics Phase 2, Phase 3

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Unknown status NCT02149615 Phase 4
2 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
3 Treatment of Diabetic Macular Edema (DME) With Intravitreal Anti-vascular Endothelial Growth Factor (Anti-VEGF) and Prompt Versus Deferred Focal Laser During Long-term Follow-up and Identification of Prognostic Retinal Markers Completed NCT03590444 Phase 4 Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
4 Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) When Placed Within the Lower Eye Lid Canaliculus or Both the Upper and Lower Canaliculi for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker. Not yet recruiting NCT04501367 Phase 4 Dexamethasone Intracanalicular Insert, 0.4 mg;Dexamethasone Intracanalicular Insert, 0.4 mg;Prednisone acetate 1%
5 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
6 Ozurdex in Treatment of Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
7 Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Therapy Comparing Syringe Preparation Time Using Ranibizumab Vial and Pre-filled Syringe Completed NCT03071055 Phase 2 Ranibizumab Injection [Lucentis]
8 A Long-Term Outcome Study With the IL-1 Receptor Antagonist Anakinra/Kineret in Patients With Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) A Therapeutic Approach to Study the Pathogenesis of This Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
9 Evaluation of the Feasibility, Safety and Efficacy of Venous Stenting for Internal Jugular Vein Stenosis Unknown status NCT03373292 Phase 1
10 Non-invasive Absolute Intracranial Pressure (ICP) Measurement in Patients With Open-angle Glaucoma and Papilledema Unknown status NCT02410148
11 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Unknown status NCT03273179
12 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Unknown status NCT02992262
13 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858
14 Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy Unknown status NCT03490318
15 Clinical Outcomes of Prolensa (Bromfenac Ophthalmic Solution) 0.07% QD vs. Ilevro (Nepafenac Ophthalmic Suspension) 0.3% QD for Treatment of Ocular Inflammation Associated With Cataract Surgery Completed NCT01847638 Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
16 Retinal Nerve Fibre Layer in Uveitic Secondary Glaucoma Completed NCT01170481
17 LUMINOUS: Study to Observe the Effectiveness and Safety of Ranibizumab Through Individualized Patient Treatment and Associated Outcomes Completed NCT01318941 Ranibizumab
18 Precise High Resolution MRI to Increase Accuracy and Gain Confidence to Diagnose Patients With Optic Disc Edema Recruiting NCT04448613
19 Determination of Normal Measures of Optic Nerve Sheath Diameter in Children Recruiting NCT03178760
20 Evaluating Raised Intracranial Pressure Using MR Elastography Active, not recruiting NCT03096743
21 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
22 A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Available NCT01487044 Macugen (Pegaptanib Sodium)
23 Resistant Diabetic Macular Edema and Suprachoroidal Injection Not yet recruiting NCT04690608 Early Phase 1 Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1
24 Ovarian Cancer Early Detection Screening Program Terminated NCT01292733 Early Phase 1
25 Incidence and Causes of Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Optic Papillitis

Cochrane evidence based reviews: papilledema

Genetic Tests for Optic Papillitis

Anatomical Context for Optic Papillitis

MalaCards organs/tissues related to Optic Papillitis:

40
Tongue, Eye, Endothelial, Kidney, Liver, Cortex, Retina

Publications for Optic Papillitis

Articles related to Optic Papillitis:

(show top 50) (show all 783)
# Title Authors PMID Year
1
CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME-ASSOCIATED UVEITIS AND PAPILLITIS. 61
30134363 2021
2
Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis. 61
33779397 2021
3
Post COVID-19 Ophthalmic Manifestations in an Asian Indian Male. 61
33733987 2021
4
Papillitis, a Rare Cytomegalovirus Manifestation in an Immunocompetent Host. 61
32235231 2021
5
Microvasculopathy in Lyme-Associated Papillitis Revealed by Optical Coherence Tomographic Angiography. 61
33770008 2021
6
Cytomegalovirus optic neuropathy in a young immunocompetent patient. 61
33721197 2021
7
Clinical challenge - scratching the surface of the sheath. 61
33610587 2021
8
12. Review of diabetic papillitis. 61
33549309 2021
9
Bilateral papillitis concomitant with cytomegalovirus primo-infection in an immunocompetent patient. 61
33612286 2021
10
Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital. 61
33652010 2021
11
Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children. 61
33323343 2021
12
Vitreopapillary Traction Masquerading as Papillitis and Papilledema. 61
33417415 2021
13
Tocilizumab Employment in the Treatment of Resistant Juvenile Idiopathic Arthritis Associated Uveitis. 61
33021415 2021
14
Tailored access to the hepatobiliary system in post-bariatric patients: a tertiary care bariatric center experience. 61
31993808 2020
15
HYPERAUTOFLUORESCENT SPOTS IN ACUTE OCULAR TOXOPLASMOSIS: A New Indicator of Outer Retinal Inflammation. 61
31923122 2020
16
Anti-GFAP neuroinflammation with synchronous bilateral papillitis and characteristic imaging. 61
33334873 2020
17
Papillitis with retinal venous congestion and intraocular inflammation. 61
32984653 2020
18
Bilateral diabetic papillopathy developed after starting insulin treatment. Potential toxic effect of insulin? A case report. 61
33353425 2020
19
Etiology of Optic Disc Swelling in a Tertiary Care Center in Nigeria. 61
33355822 2020
20
Reactive AA Amyloidosis in the setting of infective endocarditis manifesting as bilateral orbitopathy and choroidopathy. 61
33394958 2020
21
Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. 61
32556494 2020
22
Anti-VEGF Therapy and Retinal Photocoagulation to Prevent Recurrence of Central Retinal Vein Occlusion: Two Case Reports of Young Patients. 61
33300598 2020
23
Optical coherence tomography angiography in neuro-ophthalmology: Current clinical role and future perspectives. 61
33157113 2020
24
Ocular syphilis 61
33161392 2020
25
Rapidly progressive vision loss due to fulminant idiopathic intracranial hypertension: a diagnostic and management dilemma. 61
33148594 2020
26
Inflammatory choroiditis and papillitis from Crohn's disease in a child. 61
33127473 2020
27
Lyme disease atypically presenting with a singular symptom: Unilateral chorioretinitis. 61
32998513 2020
28
Homonymous visual field defects in patients with multiple sclerosis: results of computerised perimetry and optical coherence tomography. 61
33035355 2020
29
Vitreomacular traction associated with papillitis. 61
32490288 2020
30
Atypical papillitis: An isolated manifestation of Lyme disease. 61
31167569 2020
31
Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology. 61
32642595 2020
32
Implications of pars planitis-associated cystoid macular edema on visual outcome and management in children. 61
32346784 2020
33
Recurrent ascending cholangitis with acute pancreatitis and pancreatic atrophy caused by a juxtapapillary duodenal diverticulum: A case report and literature review. 61
32629744 2020
34
Investigation of oral atopic diseases: Correlation between geographic tongue and fungiform papillary glossitis. 61
32540362 2020
35
Long-term prophylaxis in an immunocompetent patient with Cytomegalovirus retinitis: a case report and review of literature. 61
32588149 2020
36
BILATERAL SEROUS RETINAL DETACHMENT AND UVEITIS ASSOCIATED WITH PEMBROLIZUMAB TREATMENT IN METASTATIC MELANOMA. 61
32243282 2020
37
Development of Acute Vogt-Koyanagi-Harada-like Syndrome during the Treatment Course with Vemurafenib for Metastatic Melanoma. 61
31161956 2020
38
Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review. 61
31889521 2020
39
[Clinical characteristics, treatment and prognosis of myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in children]. 61
32187912 2020
40
Incipient Syphilitic Papillitis. 61
32076443 2020
41
Diagnosis of Syphilitic Bilateral Papillitis Mimicking Papilloedema. 61
31855531 2020
42
A Case of Cerebral Granuloma and Optic Papillitis due to Brucella sp. 61
32733718 2020
43
Acute Visual Loss Secondary to Arnold Chiari Type I Malformation Completely Resolving After Decompressive Posterior Fossa Surgery. 61
33239924 2020
44
Clinical Features of Ocular Syphilis: a Retrospective Clinical Study in an Italian Referral Centre. 61
32036734 2020
45
Lightning Injury to Eye: Brief Review of the Literature and Case Series. 61
32184548 2020
46
Demographic and Clinical Features of Pediatric Uveitis in Israel. 61
30332547 2020
47
Combination of CT findings can reliably predict radiolucent common bile duct stones: a novel approach using a CT-based nomogram. 61
31115625 2019
48
Case report: Bilateral uveitis and papillitis secondary to treatment with pembrolizumab. 61
31755465 2019
49
Choroidal Structural Changes in Patients with Birdshot Chorioretinopathy. 61
31714872 2019
50
Papillitis in Neurosyphilis. 61
31915744 2019

Variations for Optic Papillitis

Expression for Optic Papillitis

Search GEO for disease gene expression data for Optic Papillitis.

Pathways for Optic Papillitis

Pathways related to Optic Papillitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 SAG RBP3 CRP

GO Terms for Optic Papillitis

Cellular components related to Optic Papillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 MOG CD4 AQP4 ACE

Molecular functions related to Optic Papillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 TNFRSF10A NLRP3 MRAP CRP CD4 AQP4

Sources for Optic Papillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....