MCID: OPT010
MIFTS: 29

Optic Papillitis

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Optic Papillitis

Summaries for Optic Papillitis

MalaCards based summary : Optic Papillitis, also known as papilledema, is related to papilledema and kidney papillary necrosis, and has symptoms including edema An important gene associated with Optic Papillitis is ISCA1 (Iron-Sulfur Cluster Assembly 1). The drugs Acetazolamide and Isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include ovary and kidney.

Wikipedia : 76 Optic papillitis is a specific type of optic neuritis. Inflammation of the optic nerve head is called... more...

Related Diseases for Optic Papillitis

Diseases related to Optic Papillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 papilledema 12.6
2 kidney papillary necrosis 11.4
3 hydrocephalus 11.3
4 papilloma of choroid plexus 11.1
5 optic neuritis 11.1
6 colloid cysts of third ventricle 10.9
7 intracranial hypertension 10.4
8 intracranial hypertension, idiopathic 10.2
9 pseudopapilledema 10.1
10 cerebritis 10.1
11 headache 10.1
12 pneumonia 9.9
13 acute retinal necrosis syndrome 9.9 CD40LG MRAP
14 iritis 9.8 CD40LG MRAP
15 iridocyclitis 9.8 CD40LG MRAP
16 early yaws 9.8 CD40LG EXTL3
17 transient arthritis 9.8 CD40LG MRAP
18 syphilitic meningitis 9.8 CD40LG EXTL3
19 cervix disease 9.8 CD40LG MRAP
20 primary syphilis 9.8 CD40LG EXTL3
21 retinal detachment 9.8
22 retinitis 9.8
23 meningitis 9.8
24 vulvitis 9.8 CD40LG MRAP
25 tertiary syphilis 9.8 CD40LG EXTL3
26 latent syphilis 9.8 CD40LG EXTL3
27 acute salpingitis 9.8 CD40LG MRAP
28 congenital syphilis 9.8 CD40LG EXTL3
29 urethral syndrome 9.8 CD40LG MRAP
30 secondary syphilis 9.8 CD40LG EXTL3
31 coccidiosis 9.7 CD40LG MRAP
32 asymptomatic neurosyphilis 9.7 CD40LG EXTL3
33 byssinosis 9.7 CD40LG MRAP
34 panuveitis 9.7 CD40LG MRAP
35 conjunctival disease 9.7 CD40LG MRAP
36 neuroretinitis 9.6 CD40LG EXTL3
37 hypersensitivity reaction type iv disease 9.6 CD40LG MRAP
38 syphilis 9.6 CD40LG EXTL3
39 tertiary neurosyphilis 9.5 CD40LG EXTL3
40 spondyloarthropathy 1 9.5 CD40LG MRAP
41 primary bacterial infectious disease 9.3 CD40LG EXTL3
42 bone inflammation disease 9.3 CD40LG MRAP
43 chorioretinitis 9.3 CD40LG EXTL3 MRAP
44 urethritis 9.3 CD40LG EXTL3 MRAP
45 behcet syndrome 9.1 CD40LG MRAP

Graphical network of the top 20 diseases related to Optic Papillitis:



Diseases related to Optic Papillitis

Symptoms & Phenotypes for Optic Papillitis

UMLS symptoms related to Optic Papillitis:


edema

Drugs & Therapeutics for Optic Papillitis

Drugs for Optic Papillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
2
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
3
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
4
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
5
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
6 diuretics Phase 4,Phase 2,Phase 3
7 Natriuretic Agents Phase 4,Phase 2,Phase 3
8 Anticonvulsants Phase 4,Phase 2,Phase 3
9 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
10 Dermatologic Agents Phase 4
11 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 2
13
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
14
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
15
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
16
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
17
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
18
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
19
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
20
Warfarin Approved Phase 3 81-81-2 6691 54678486
21
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
22 Analgesics Phase 2, Phase 3,Not Applicable
23 glucocorticoids Phase 2, Phase 3,Phase 1
24 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
25 Hormone Antagonists Phase 2, Phase 3,Phase 1
26 Hormones Phase 2, Phase 3,Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1
28 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
29 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
30 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
31 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Not Applicable
32 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
33
protease inhibitors Phase 2, Phase 3,Phase 3
34 Fibrinolytic Agents Phase 2, Phase 3
35 Respiratory System Agents Phase 2, Phase 3
36 Central Nervous System Depressants Phase 2, Phase 3
37 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
38 Gastrointestinal Agents Phase 2, Phase 3
39 Narcotics Phase 2, Phase 3
40 Cyclooxygenase Inhibitors Phase 2, Phase 3
41 Analgesics, Opioid Phase 2, Phase 3
42 HIV Protease Inhibitors Phase 2, Phase 3,Phase 3
43 Platelet Aggregation Inhibitors Phase 2, Phase 3
44 Antiemetics Phase 2, Phase 3
45 Antipyretics Phase 2, Phase 3
46 Antitussive Agents Phase 2, Phase 3
47 BB 1101 Phase 2, Phase 3
48 Autonomic Agents Phase 2, Phase 3
49 Antineoplastic Agents, Hormonal Phase 2, Phase 3
50 Dabigatran Phase 3

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
2 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
3 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
4 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
5 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
6 The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis Recruiting NCT03217448 Phase 3 Dabigatran etexilate;Warfarin
7 Surgical Idiopathic Intracranial Hypertension Treatment Trial Not yet recruiting NCT03501966 Phase 3 Acetazolamide
8 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
9 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
10 Intravitreal Aflibercept Injection for Radiation Retinopathy Trial Recruiting NCT03085784 Phase 2 Aflibercept
11 Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Recruiting NCT03071055 Phase 2 Ranibizumab Injection [Lucentis]
12 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide
13 Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
14 Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection Terminated NCT01562132 Phase 2 Flucytosine and fluconazole;Fluconazole
15 Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis Not yet recruiting NCT03373292 Phase 1
16 aICP in Glaucoma and Papilledema Unknown status NCT02410148 Not Applicable
17 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858 Not Applicable
18 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Unknown status NCT01847638 Not Applicable Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
19 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481
20 Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine? Completed NCT00873613 Not Applicable
21 Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI) Completed NCT01356134
22 Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Completed NCT01318941 Ranibizumab
23 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179
24 Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure Recruiting NCT03178760
25 An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH Recruiting NCT02124486 Not Applicable
26 Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome Recruiting NCT02896452
27 Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases) Recruiting NCT00059748
28 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743 Not Applicable
29 Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy Recruiting NCT03490318
30 Korean Registry of Target Organ Damages in Hypertension Recruiting NCT01861080
31 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Recruiting NCT02143258 Not Applicable
32 A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Available NCT01487044 Macugen (Pegaptanib Sodium)
33 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Not yet recruiting NCT02992262 Not Applicable
34 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial Not yet recruiting NCT02513914 Not Applicable
35 Venous Sinus Stenting With the River Stent in IIH Not yet recruiting NCT03556085 Not Applicable
36 Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography Suspended NCT03037268
37 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Optic Papillitis

Cochrane evidence based reviews: papilledema

Genetic Tests for Optic Papillitis

Anatomical Context for Optic Papillitis

MalaCards organs/tissues related to Optic Papillitis:

41
Ovary, Kidney

Publications for Optic Papillitis

Articles related to Optic Papillitis:

# Title Authors Year
1
Myelin Oligodendrocyte Glycoprotein-IgG-positive Recurrent Bilateral Optic Papillitis with Serous Retinal Detachment: A Case Report. ( 29780155 )
2018
2
Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection. ( 21732064 )
2012
3
Bilateral optic papillitis following mycoplasma pneumoniae pneumonia. ( 9693295 )
1998

Variations for Optic Papillitis

Expression for Optic Papillitis

Search GEO for disease gene expression data for Optic Papillitis.

Pathways for Optic Papillitis

GO Terms for Optic Papillitis

Sources for Optic Papillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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