Oral Cavity Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ORL007 MIFTS: 61	Oral Cavity Cancer Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Oral Cavity Cancer

MalaCards integrated aliases for Oral Cavity Cancer:

Name: Oral Cavity Cancer ¹² ¹⁵

Malignant Neoplasm of Anterior Portion of Floor of Mouth ¹²

Malignant Neoplasm of Lateral Portion of Floor of Mouth ¹²

Malignant Neoplasm of Lateral Floor of Mouth ¹²

Malignant Tumor of Anterior Floor of Mouth ¹²

Malignant Tumor of Lateral Floor of Mouth ¹²

Malignant Tumor of the Floor of the Mouth ¹²

Malignant Neoplasm of Floor of Mouth ¹²

Malignant Tumor of Floor of Mouth ⁶

Neoplasm of the Oral Cavity ²⁹

Malignant Neoplasm of Mouth ⁷³

Oral Cavity Carcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of floor of mouth

Malignant neoplasm: Anterior floor of mouth

Malignant neoplasm: Floor of mouth, unspecified

Malignant neoplasm: Lateral floor of mouth

External Ids:

Disease Ontology ¹² DOID:8618

ICD10 ³³ C04 C04.0 C04.1 more

ICD9CM ³⁵ 144 144.0 144.1 more

NCIt ⁵⁰ C9318

SNOMED-CT ⁶⁸ 93672006 93802007 93860002

UMLS ⁷³ C0153368 C0153369 C0496758 more

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Summaries for Oral Cavity Cancer

Disease Ontology : ¹² A gastrointestinal system cancer that is located in the oral cavity.

MalaCards based summary : Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to leukoplakia and lip and oral cavity cancer. An important gene associated with Oral Cavity Cancer is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and testes, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

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Related Diseases for Oral Cavity Cancer

Diseases in the Oral Cavity Cancer family:

Oral Cavity Carcinoma in Situ

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)

#	Related Disease	Score	Top Affiliating Genes
1	leukoplakia	30.4	CYP1A1 GSTM1 GSTT1
2	lip and oral cavity cancer	12.5
3	oral squamous cell carcinoma	11.1
4	salivary gland carcinoma	11.1
5	breast intraductal proliferative lesion	10.4	EGFR ERBB2
6	geographic tongue	10.4	EGFR TNFRSF10B VEGFA
7	colorectal cancer, childhood	10.4	CYP1A1 GSTM1
8	primary peritoneal carcinoma	10.4	EGFR ERBB2 VEGFA
9	breast carcinoma in situ	10.3	EGFR ERBB2 VEGFA
10	sister chromatid exchange, frequency of	10.3	ALDH2 GSTM1 GSTT1
11	laryngeal disease	10.3	EGFR GSTM1 GSTT1
12	oral submucous fibrosis	10.3	CYP1A1 GSTM1 GSTT1
13	pharynx cancer	10.3	EGFR GSTM1 VEGFA
14	esophageal disease	10.3	ALDH2 EGFR ERBB2
15	oral cancer	10.3	CYP1A1 EGFR GSTM1 GSTT1
16	nervous system cancer	10.3	EGFR PTEN VEGFA
17	bladder disease	10.3	ERBB2 GSTM1 GSTT1
18	hearing loss, noise-induced	10.3	GSTM1 GSTT1
19	stomach disease	10.3	EGFR ERBB2 VEGFA
20	laryngeal squamous cell carcinoma	10.3	EGFR GSTT1 VEGFA
21	breast squamous cell carcinoma	10.3	EGFR ERBB2 PIK3CA
22	breast disease	10.3	BAX CYP1A1 ERBB2 VEGFA
23	adenosquamous lung carcinoma	10.3	EGFR ERBB2 PIK3CA
24	acneiform dermatitis	10.3	CYP1A1 EGFR ERBB2 PIK3CA
25	supratentorial cancer	10.3	EGFR PTEN SOX2 VEGFA
26	cerebrum cancer	10.3	EGFR PTEN SOX2 VEGFA
27	ovarian cancer 1	10.3	ERBB2 PIK3CA VEGFA
28	malignant ovarian surface epithelial-stromal neoplasm	10.3	ERBB2 PIK3CA VEGFA
29	central nervous system cancer	10.3	EGFR PTEN SOX2 VEGFA
30	ovary epithelial cancer	10.3	ERBB2 PIK3CA VEGFA
31	female reproductive system disease	10.3	EGFR ERBB2 PTEN VEGFA
32	mucinous stomach adenocarcinoma	10.3	PTEN VEGFA
33	reproductive system disease	10.3	EGFR ERBB2 PTEN VEGFA
34	endometrial adenocarcinoma	10.3	EGFR ERBB2 PTEN VEGFA
35	serous cystadenocarcinoma	10.3	ERBB2 PIK3CA VEGFA
36	ovary adenocarcinoma	10.3	BAX ERBB2 PIK3CA
37	cystadenocarcinoma	10.3	ERBB2 PIK3CA VEGFA
38	estrogen-receptor positive breast cancer	10.3	EGFR ERBB2 PIK3CA
39	grade iii astrocytoma	10.3	EGFR PTEN VEGFA
40	endocrine gland cancer	10.3	EGFR ERBB2 PTEN VEGFA
41	adult hepatocellular carcinoma	10.3	CASP8 PIK3CA
42	pancreas adenocarcinoma	10.3	EGFR ERBB2 PIK3CA VEGFA
43	larynx cancer	10.2	EGFR GSTM1 GSTT1 PTEN
44	acute t cell leukemia	10.2	BAX CASP8 PTEN
45	acute lymphocytic leukemia	10.2	GSTM1 GSTT1 MCL1
46	thyroid hurthle cell adenoma	10.2	PIK3CA PTEN
47	carcinosarcoma	10.2	ERBB2 PIK3CA PTEN
48	progesterone-receptor negative breast cancer	10.2	EGFR ERBB2
49	ovarian serous cystadenocarcinoma	10.2	BAX ERBB2 PIK3CA
50	uterine anomalies	10.2	ERBB2 PIK3CA PTEN VEGFA

Comorbidity relations with Oral Cavity Cancer via Phenotypic Disease Network (PDN):

Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Oral Cavity Cancer:

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Symptoms & Phenotypes for Oral Cavity Cancer

GenomeRNAi Phenotypes related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance	GR00210-A	9.35	EGFR ERBB2 GSTM1 PTEN VEGFA
2	Decreased viability with paclitaxel	GR00179-A-1	8.92	EGFR ERBB2 FADD
3	Decreased viability with paclitaxel	GR00179-A-3	8.92	EGFR

MGI Mouse Phenotypes related to Oral Cavity Cancer:

⁴⁶ (show all 21)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.43	ALDH2 BAX CASP8 CYP1A1 EGFR ERBB2
2	cardiovascular system	MP:0005385	10.41	ALDH2 CASP8 CYP1A1 EGFR ERBB2 FADD
3	cellular	MP:0005384	10.4	ALDH2 BAX CASP8 EGFR ERBB2 FADD
4	endocrine/exocrine gland	MP:0005379	10.38	ALDH2 BAX CASP8 CYP1A1 EGFR ERBB2
5	homeostasis/metabolism	MP:0005376	10.38	ALDH2 BAX CASP8 CYP1A1 EGFR ERBB2
6	mortality/aging	MP:0010768	10.38	ALDH2 BAX CASP8 CYP1A1 EGFR ERBB2
7	immune system	MP:0005387	10.34	ALDH2 BAX CASP8 CYP1A1 EGFR FADD
8	hematopoietic system	MP:0005397	10.33	ALDH2 BAX CASP8 CYP1A1 EGFR FADD
9	embryo	MP:0005380	10.32	CASP8 EGFR ERBB2 FADD HSP90B1 LIN28B
10	muscle	MP:0005369	10.23	ALDH2 BAX CASP8 EGFR ERBB2 FADD
11	nervous system	MP:0003631	10.22	ALDH2 BAX CASP8 EGFR ERBB2 FADD
12	integument	MP:0010771	10.21	ALDH2 CASP8 EGFR ERBB2 MCL1 PIK3CA
13	liver/biliary system	MP:0005370	10.15	ALDH2 CASP8 CYP1A1 EGFR FADD GDF15
14	digestive/alimentary	MP:0005381	10.13	EGFR ERBB2 FADD PTEN SOX2 TLR2
15	neoplasm	MP:0002006	10.13	ALDH2 BAX CASP8 EGFR ERBB2 PIK3CA
16	normal	MP:0002873	9.97	CYP1A1 EGFR ERBB2 LIN28B MCL1 PTEN
17	no phenotypic analysis	MP:0003012	9.91	CYP1A1 EGFR FADD HSP90B1 PIK3CA SOX2
18	renal/urinary system	MP:0005367	9.86	ALDH2 BAX CASP8 EGFR GDF15 PTEN
19	reproductive system	MP:0005389	9.81	ALDH2 BAX EGFR ERBB2 MCL1 PIK3CA
20	respiratory system	MP:0005388	9.56	BAX CASP8 EGFR ERBB2 PTEN SOX2
21	skeleton	MP:0005390	9.32	ALDH2 BAX EGFR ERBB2 FADD PIK3CA

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Drugs & Therapeutics for Oral Cavity Cancer

Drugs for Oral Cavity Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 393)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Racepinephrine

Approved

Phase 4,Phase 2,Phase 1

329-65-7

838

Epinephrine

Approved, Vet_approved

Phase 4,Phase 2,Phase 1

51-43-4

5816

Dopexamine

Approved, Investigational

Phase 4

86197-47-9

55483

Dobutamine

Approved

Phase 4,Not Applicable

34368-04-2

36811

Norepinephrine

Approved

Phase 4,Not Applicable

51-41-2

439260

Dopamine

Approved

Phase 4,Phase 2

51-61-6, 62-31-7

681

Edetic Acid

Approved, Vet_approved

Phase 4

62-33-9, 60-00-4

6049

Pentetic acid

Approved

Phase 4

67-43-6

Bupropion

Approved

Phase 4,Phase 2

34841-39-9, 34911-55-2

444

Nicotine

Approved

Phase 4,Not Applicable

54-11-5

942 89594

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

657-24-9

14219 4091

Vasoconstrictor Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Adrenergic beta-Agonists

Phase 4,Phase 2,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Sympathomimetics

Phase 4,Phase 2,Not Applicable

Epinephryl borate

Phase 4,Phase 2,Phase 1

Adrenergic alpha-Agonists

Phase 4,Phase 2,Phase 3,Not Applicable

Mydriatics

Phase 4,Phase 2

Autonomic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Adrenergic Agonists

Phase 4,Phase 2,Phase 3,Not Applicable

Respiratory System Agents

Phase 4,Phase 2,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 2

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Adrenergic Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Protective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Bronchodilator Agents

Phase 4,Phase 2

Anticoagulants

Phase 4,Not Applicable

Radiopharmaceuticals

Phase 4,Phase 1,Phase 2,Not Applicable

Chelating Agents

Phase 4,Not Applicable,Early Phase 1

Liver Extracts

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 2,Phase 3

HIV Protease Inhibitors

Phase 4,Phase 2,Phase 3

protease inhibitors

Phase 4,Phase 2,Phase 3

Calcium, Dietary

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Vasodilator Agents

Phase 4,Not Applicable

Dopamine agonists

Phase 4

Cardiotonic Agents

Phase 4,Not Applicable

Dopamine Agents

Phase 4,Phase 2

Blood Substitutes

Phase 4

Technetium Tc 99m Sulfur Colloid

Phase 4,Not Applicable

Technetium Tc 99m Pentetate

Phase 4

Dextrans

Phase 4

Plasma Substitutes

Phase 4

Antidepressive Agents

Phase 4,Phase 3,Phase 2

Antidepressive Agents, Second-Generation

Phase 4,Phase 2

Dopamine Uptake Inhibitors

Phase 4,Phase 2

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 3,Phase 2,Phase 1

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4,Phase 2

Nicotinic Agonists

Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 579)

#	Name	Status	NCT ID	Phase	Drugs
1	Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery	Completed	NCT01418118	Phase 4	Epinephrine;Norepinephrine;Dobutamine;Dopexamine
2	Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer	Completed	NCT02287675	Phase 4	Lymphoseek;Sulfur Colloid
3	Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking	Completed	NCT00666978	Phase 4	bupropion hydrochloride
4	Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking	Completed	NCT00365508	Phase 4	nicotine lozenge;nicotine patch
5	Stereotactic Body Radiotherapy for Head and Neck Tumors	Completed	NCT01344356	Phase 4
6	Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia	Completed	NCT00155337	Phase 4
7	The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor	Recruiting	NCT03017053	Phase 4
8	Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions	Recruiting	NCT03684707	Phase 4	Metformin Hcl 500Mg 24Hr Sa Tab
9	Aliskiren Study of Safety and Efficacy in Senior Hypertensives	Withdrawn	NCT01922141	Phase 4	Aliskiren;Amlodipine;Ramipril;Hydrochlorothiazide
10	Oral Cancer Screening in Mumbai, India by Primary Health Care Workers	Unknown status	NCT00655421	Phase 3
11	Oral Cancer Adjuvant Therapy (OCAT) Trial	Unknown status	NCT00193843	Phase 3
12	Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL	Unknown status	NCT01039298	Phase 3
13	Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer	Unknown status	NCT00002747	Phase 3	cisplatin;fluorouracil
14	Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx	Unknown status	NCT00002702	Phase 3
15	Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.	Unknown status	NCT00964977	Phase 3
16	The Feasibility of Dexmedetomidine for Awake Fiberoptic Nasal Intubation	Unknown status	NCT00815893	Phase 2, Phase 3	dexmedetomidine;Normal Saline 0.9%;propofol 1%
17	Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer	Unknown status	NCT00022373	Phase 3	iseganan HCl oral solution
18	PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer	Unknown status	NCT00720070	Phase 3
19	Study of I-125 Brachytherapy Versus Intensity-modulated Radiation Therapy to Treat Inoperable Salivary Gland Cancer	Unknown status	NCT02048254	Phase 3
20	Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors	Unknown status	NCT01216800	Phase 3
21	Erlotinib Prevention of Oral Cancer (EPOC)	Completed	NCT00402779	Phase 3	Erlotinib;Placebo
22	Workplace Tobacco Cessation And Oral Cancer Screening Study	Completed	NCT00750503	Phase 3
23	Post-Operative Adjuvant Concurrent Chemoradiotherapy For High Risk Oral Cavity Squamous Cell Carcinoma Patients	Completed	NCT00201383	Phase 3	cisplatin
24	Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity	Completed	NCT01265849	Phase 3
25	Oral Mucositis in Patients Receiving Radiation Therapy for Cancer of the Mouth, Pharynx, or Larynx	Completed	NCT00004234	Phase 3
26	Phase II Trial of Allovectin-7® for Head and Neck Cancer	Completed	NCT00050388	Phase 3
27	Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma	Completed	NCT00201279	Phase 3	13-cis Retino Acid
28	Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer	Completed	NCT01434394	Phase 2, Phase 3	Neo-adjuvant Erbitux-based chemotherapy
29	Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population	Completed	NCT00359645	Phase 3
30	Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC	Completed	NCT00158652	Phase 3	5FU, Paraplatin
31	Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC	Completed	NCT00162708	Phase 2, Phase 3	CDDP, 5 Fu
32	Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer	Completed	NCT00008398	Phase 3
33	Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy	Completed	NCT01156142	Phase 3	doxepin hydrochloride
34	Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Completed	NCT00538850	Phase 3	Fentanyl sublingual spray;Placebo
35	Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract	Completed	NCT00765440	Phase 3
36	Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer	Completed	NCT00090337	Phase 3
37	Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Completed	NCT00002533	Phase 2, Phase 3	fluconazole
38	Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer	Completed	NCT00017511	Phase 3	cevimeline hydrochloride
39	Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer	Completed	NCT00006799	Phase 3	megestrol acetate
40	Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer	Completed	NCT00002507	Phase 3	mitomycin C;porfiromycin
41	Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer	Completed	NCT00002476	Phase 3	fluorouracil;leucovorin calcium;methotrexate;vincristine sulfate
42	Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Completed	NCT00656513	Phase 2, Phase 3	Pilocarpine
43	Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer	Completed	NCT00820248	Phase 3	cisplatin
44	The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome	Completed	NCT01414790	Phase 3
45	Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions	Recruiting	NCT03685409	Phase 3	Metformin Hydrochloride 500 MG;Placebo Oral Tablet
46	DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer	Recruiting	NCT03237325	Phase 3	SGX942;Placebo
47	Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers	Recruiting	NCT02868151	Phase 2, Phase 3	Ascorbic Acid;Zinc acetate
48	Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck	Recruiting	NCT02236936	Phase 3	Cisplatin
49	IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC	Active, not recruiting	NCT00158678	Phase 3	concomitant cisplatin
50	Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma	Active, not recruiting	NCT00588770	Phase 3	Carboplatin;Cisplatin;Docetaxel;Fluorouracil

Search NIH Clinical Center for Oral Cavity Cancer

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Genetic Tests for Oral Cavity Cancer

Genetic tests related to Oral Cavity Cancer:

#	Genetic test	Affiliating Genes
1	Neoplasm of the Oral Cavity ²⁹

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Anatomical Context for Oral Cavity Cancer

MalaCards organs/tissues related to Oral Cavity Cancer:

⁴¹

Lymph Node, Lung, Testes, Tongue, Bone, Eye, Salivary Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Oral Cavity Cancer:

¹⁹

The Oral Cavity

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Publications for Oral Cavity Cancer

Articles related to Oral Cavity Cancer:

(show top 50) (show all 325)

#	Title	Authors	Year
1	Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients. ( 30322742 )	Janz TA...Day TA	2019
2	Oral Cavity Cancer. ( 30454788 )	Ettinger KS...Fernandes RP	2019
3	Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience. ( 29706184 )	Foster C.C....Haraf D.J.	2018
4	Association of Time between Surgery and Adjuvant Therapy with Survival in Oral Cavity Cancer. ( 29313448 )	Chen M.M....Divi V.	2018
5	Detection of surgical margins in oral cavity cancer: the role of dynamic optical contrast imaging. ( 29517537 )	Pellionisz P.A....St John M.A.	2018
6	Low expression of CD40L in tumor-free lymph node of oral cavity cancer related with poor prognosis. ( 29761306 )	Rah Y.C....Ahn S.H.	2018
7	Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins? ( 29790687 )	Strzelczyk J.K....Owczarek A.J.	2018
8	Locoregionally advanced oral cavity cancer: A propensity-score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy. ( 29665118 )	Shin J.Y....Diaz A.Z.	2018
9	The influence of insurance status on treatment and outcomes in oral cavity cancer: an analysis on 46,373 patients. ( 29655817 )	Shin J.Y....Diaz A.Z.	2018
10	MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: Preliminary clinical study. ( 29633413 )	Bae S....Kim J.	2018
11	The influence of marital status on survival for patients aged 65 years and younger with oral cavity cancer. ( 29685504 )	Liao P.H....Lee C.C.	2018
12	The effectiveness of a saline mouth rinse regimen and education programme on radiation-induced oral mucositis and quality of life in oral cavity cancer patients: A randomised controlled trial. ( 29315944 )	Huang B.S....Chen S.C.	2018
13	Effects of a swallowing exercise education program on dysphagia-specific health-related quality of life in oral cavity cancer patients post-treatment: a randomized controlled trial. ( 29546525 )	Chen S.C....Wu S.C.	2018
14	Opioid prescribing practices in patients undergoing surgery for oral cavity cancer. ( 29756393 )		2018
15	Genetic analysis of surgical margins in oral cavity cancer. ( 29341160 )		2018
16	Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival. ( 29480612 )		2018
17	Aberrant DNA methylation of the <i>p16, APC, MGMT, TIMP3</i> and <i>CDH1</i> gene promoters in tumours and the surgical margins of patients with oral cavity cancer. ( 29896273 )		2018
18	Diagnostic Pathway of Oral Cavity Cancer in an Integrated Health Care System. ( 29616906 )		2018
19	Can MR textural analysis improve the prediction of extracapsular nodal spread in patients with oral cavity cancer? ( 29872911 )		2018
20	Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system. ( 29739969 )		2018
21	Complete atrioventricular block as an initial manifestation of recurred oral cavity cancer: a case report. ( 29986652 )	Cho JY...Park JC	2018
22	Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women. ( 30233243 )	Qin L...Wu SY	2018
23	Swallowing ability and its impact on dysphagia-specific health-related QOL in oral cavity cancer patients post-treatment. ( 30322515 )	Chen SC...Wu SC	2018
24	High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands. ( 29575685 )	Boeve K...Witjes MJH	2018
25	Author Correction: Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system. ( 29991743 )	Dong F...Lyu P	2018
26	Diagnostic pathway of oral cavity cancer in an integrated health care system. ( 30095106 )		2018
27	Adjuvant radiation for T1-2N1 oral cavity cancer survival outcomes and utilization treatment trends: Analysis of the SEER database. ( 30220313 )	Torrecillas V...Cannon RB	2018
28	Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Stage I to II Oral Cavity Cancer. ( 30284248 )	Cramer JD...Samant S	2018
29	Toward complete oral cavity cancer resection using a handheld diffuse reflectance spectroscopy probe. ( 30341837 )	Brouwer de Koning SG...Ruers TJM	2018
30	Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution. ( 30349385 )	Chen SW...Song M	2018
31	Does anatomic subsite influence oral cavity cancer mortality? A SEER database analysis. ( 30408182 )	Farhood Z...Osazuwa-Peters N	2018
32	Evaluation of early oral cavity cancer treatment quality at a single institution. ( 30408196 )	Chang S...Yaremchuk K	2018
33	Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer. ( 30452499 )	Ding D...Karam SD	2018
34	Untreated oral cavity cancer: Long-term survival and factors associated with treatment refusal. ( 28865100 )	Cheraghlou S....Judson B.L.	2017
35	Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer. ( 28880746 )	Ho A.S....Zumsteg Z.S.	2017
36	Recent Trends in Oral Cavity Cancer Research Support in the United States. ( 28033064 )	Fribley A.M....Kirkwood K.L.	2017
37	Comparison of facility type outcomes for oral cavity cancer: Analysis of the national cancer database. ( 28671267 )	Rubin S.J....Jalisi S.	2017
38	Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis. ( 28426848 )	Spiotto M.T....Koshy M.	2017
39	Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow. ( 28806994 )	Mohamed A.S.R....Garden A.S.	2017
40	Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer. ( 29257122 )	Drop B....Polz-Dacewicz M.	2017
41	Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy. ( 28797467 )	Quinlan-Davidson S.R....Garden A.S.	2017
42	Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery. ( 28321535 )	Tangthongkum M....Leelasawatsuk P.	2017
43	What additional treatment is indicated for oral cavity cancer with isolated perineural invasion? ( 28349551 )		2017
44	Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer. ( 28448645 )		2017
45	Factors associated with continued smoking after treatment of oral cavity cancer: An age and survival time-matched study. ( 29148210 )		2017
46	Frequency of Depression and its Correlation with Quality of Life of Patients with Oral Cavity Cancer. ( 28883770 )		2017
47	Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer. ( 28838425 )		2017
48	Chronic Opioid Use Following Surgery for Oral Cavity Cancer. ( 28445584 )		2017
49	Prognostic implication of ERCC1 protein expression in resected oropharynx and oral cavity cancer. ( 28645807 )		2017
50	Primary Surgery vs Radiotherapy for Early Stage Oral Cavity Cancer. ( 29256326 )		2017

Sources

Genes for Oral Cavity Cancer

Genes related to Oral Cavity Cancer (2 elite genes):

(show all 44)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTEN	Phosphatase And Tensin Homolog	Protein Coding	404.9	Pathogenic/Likely pathogenic ⁶ DISEASES inferred ¹⁵
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	404.89	Pathogenic ⁶ DISEASES inferred ¹⁵
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	23.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	22.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	22.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CASP8	Caspase 8	Protein Coding	21.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	SOX2	SRY-Box 2	Protein Coding	21.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	21.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	21.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	FADD	Fas Associated Via Death Domain	Protein Coding	21.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	20.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	MCL1	MCL1, BCL2 Family Apoptosis Regulator	Protein Coding	20.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	LIN28B	Lin-28 Homolog B	Protein Coding	20.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	GDF15	Growth Differentiation Factor 15	Protein Coding	20.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	20.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TLR2	Toll Like Receptor 2	Protein Coding	20.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	20.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	19.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	19.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	TECR	Trans-2,3-Enoyl-CoA Reductase	Protein Coding	18.11	DISEASES inferred ¹⁵
21	SHOX2	Short Stature Homeobox 2	Protein Coding	17.97	DISEASES inferred ¹⁵ ¹⁵
22	DNAJB7	DnaJ Heat Shock Protein Family (Hsp40) Member B7	Protein Coding	8.45	DISEASES inferred ¹⁵
23	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	7.78	DISEASES inferred ¹⁵
24	MAU2	MAU2 Sister Chromatid Cohesion Factor	Protein Coding	7.66	DISEASES inferred ¹⁵
25	TLR9	Toll Like Receptor 9	Protein Coding	7.48	DISEASES inferred ¹⁵ ¹⁵
26	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	7.42	DISEASES inferred ¹⁵
27	AREG	Amphiregulin	Protein Coding	7.28	DISEASES inferred ¹⁵ ¹⁵
28	TP53	Tumor Protein P53	Protein Coding	7.16	DISEASES inferred ¹⁵
29	ISL1	ISL LIM Homeobox 1	Protein Coding	6.97	DISEASES inferred ¹⁵
30	CDH1	Cadherin 1	Protein Coding	6.87	DISEASES inferred ¹⁵
31	IL4	Interleukin 4	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
32	TNFRSF6B	TNF Receptor Superfamily Member 6b	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
33	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
34	TNFSF10	TNF Superfamily Member 10	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
35	IL18	Interleukin 18	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
36	MPO	Myeloperoxidase	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
37	NAT2	N-Acetyltransferase 2	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
38	EDNRB	Endothelin Receptor Type B	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
39	TLR6	Toll Like Receptor 6	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
40	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
41	IL4R	Interleukin 4 Receptor	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
42	HEPH	Hephaestin	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
43	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
44	CP	Ceruloplasmin	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)

Sources

Variations for Oral Cavity Cancer

ClinVar genetic disease variations for Oral Cavity Cancer:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PIK3CA	NM_006218.3(PIK3CA): c.3139C> T (p.His1047Tyr)	single nucleotide variant	Pathogenic	rs121913281	GRCh37	Chromosome 3, 178952084: 178952084
2	PIK3CA	NM_006218.3(PIK3CA): c.3139C> T (p.His1047Tyr)	single nucleotide variant	Pathogenic	rs121913281	GRCh38	Chromosome 3, 179234296: 179234296
3	PTEN	NM_000314.6(PTEN): c.388C> G (p.Arg130Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121909224	GRCh37	Chromosome 10, 89692904: 89692904
4	PTEN	NM_000314.6(PTEN): c.388C> G (p.Arg130Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121909224	GRCh38	Chromosome 10, 87933147: 87933147
5	PIK3CA	NM_006218.3(PIK3CA): c.3145G> C (p.Gly1049Arg)	single nucleotide variant	Likely pathogenic	rs121913277	GRCh37	Chromosome 3, 178952090: 178952090
6	PIK3CA	NM_006218.3(PIK3CA): c.3145G> C (p.Gly1049Arg)	single nucleotide variant	Likely pathogenic	rs121913277	GRCh38	Chromosome 3, 179234302: 179234302

Sources

Expression for Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Sources

Pathways for Oral Cavity Cancer

Pathways related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.06	CASP8 EGFR ERBB2 FADD HSP90B1 MCL1
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.88	BAX CASP8 EGFR ERBB2 FADD GDF15
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.41	BAX EGFR ERBB2 FADD GDF15 PTEN
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.38	EGFR ERBB2 HSP90B1 MCL1 PIK3CA SOX2
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.31	BAX CASP8 EGFR ERBB2 GDF15 PTEN
6	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13	BAX CASP8 EGFR FADD PIK3CA PTEN
7	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.92	BAX CASP8 EGFR FADD PIK3CA PTEN
8	Focal Adhesion ¹ ³⁷ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.91	EGFR ERBB2 PIK3CA PTEN VEGFA
9	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.85	BAX EGFR ERBB2 HSP90B1 PIK3CA PTEN
10	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ¹ Apoptosis ³⁷ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁵ Death Receptor Signaling ⁶⁷	12.81	BAX CASP8 FADD MCL1 PIK3CA TNFRSF10B
11	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.8	CASP8 FADD PIK3CA TLR2 TNFRSF10B
12	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.77	BAX EGFR ERBB2 PIK3CA PTEN VEGFA
13	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.74	BAX CASP8 EGFR ERBB2 FADD HSP90B1
14	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.71	BAX EGFR ERBB2 GSTM1 GSTT1 PIK3CA
15	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.61	CASP8 FADD PIK3CA TLR2 TNFRSF10B VEGFA
16	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁷ Inflammatory mediator regulation of TRP channels ³⁷	12.59	CASP8 EGFR FADD PIK3CA PTEN TNFRSF10B
17	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.5	EGFR ERBB2 PIK3CA PTEN
18	MicroRNAs in cancer ³⁷	12.5	EGFR ERBB2 MCL1 PIK3CA PTEN VEGFA
19	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.49	BAX ERBB2 PIK3CA PTEN
20	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.48	EGFR ERBB2 PIK3CA VEGFA
21	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.44	BAX CASP8 EGFR ERBB2 PIK3CA
22	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.41	BAX HSP90B1 PIK3CA PTEN
23	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	12.39	BAX CASP8 PTEN TNFRSF10B
24	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.34	CASP8 FADD HSP90B1 TLR2
25	Dimerization of procaspase-8 ⁶⁶ Show member pathways CASP8 activity is inhibited ⁶⁶ Caspase activation via extrinsic apoptotic signalling pathway ⁶⁶ FAS (CD95) signaling pathway ¹ Ligand-dependent caspase activation ⁶⁶ Ligand-independent caspase activation via DCC ⁶⁶ Regulated Necrosis ⁶⁶ Regulation by c-FLIP ⁶⁶ Regulation of necroptotic cell death ⁶⁶ RIPK1-mediated regulated necrosis ⁶⁶ TRAIL signaling ⁶⁶ TRAIL signaling pathway ¹	12.31	CASP8 FADD PIK3CA TNFRSF10B
26	Epstein-Barr virus infection ³⁷	12.29	BAX CASP8 FADD PIK3CA TLR2
27	Proteoglycans in cancer ³⁷	12.28	EGFR ERBB2 PIK3CA TLR2 VEGFA
28	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.27	BAX CASP8 PTEN TNFRSF10B
29	Tuberculosis ³⁷	12.25	BAX CASP8 FADD TLR2
30	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.23	BAX CASP8 FADD TNFRSF10B
31	Colorectal Cancer Metastasis ⁶⁴	12.2	BAX EGFR TLR2 VEGFA
32	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.15	EGFR ERBB2 PIK3CA PTEN
33	Apoptosis and Autophagy ⁴	12.15	BAX CASP8 FADD GDF15 MCL1 TNFRSF10B
34	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.14	BAX EGFR ERBB2 HSP90B1 PIK3CA PTEN
35	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.12	EGFR ERBB2 PIK3CA PTEN
36	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.1	BAX EGFR GDF15 PIK3CA TNFRSF10B
37	Pathways in cancer ³⁷	12.08	BAX CASP8 EGFR ERBB2 FADD GSTM1
38	AKT Signaling Pathway ⁶⁷	12.07	BAX EGFR ERBB2 HSP90B1 PIK3CA PTEN
39	Fluid shear stress and atherosclerosis ³⁷	12.06	GSTM1 GSTT1 HSP90B1 PIK3CA VEGFA
40	Integrated Breast Cancer Pathway ¹	12.03	BAX CASP8 EGFR FADD PTEN VEGFA
41	DNA Damage Response (only ATM dependent) ¹	12	BAX ERBB2 PIK3CA PTEN
42	Interleukin-4 and 13 signaling ⁶⁶	11.99	HSP90B1 MCL1 SOX2 VEGFA
43	Direct p53 effectors ¹	11.92	BAX EGFR GDF15 MCL1 PTEN TNFRSF10B
44	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.91	BAX PIK3CA VEGFA
45	HIF-1 signaling pathway ³⁷	11.91	EGFR ERBB2 PIK3CA VEGFA
46	Small cell lung cancer ³⁷	11.88	BAX PIK3CA PTEN
47	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.88	EGFR ERBB2 VEGFA
48	IL6-mediated signaling events ¹ Show member pathways IL-6 signaling pathway ¹	11.84	HSP90B1 MCL1 PIK3CA
49	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.83	CASP8 EGFR ERBB2 HSP90B1 PIK3CA TLR2
50	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ Apoptosis - multiple species ³⁷ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶	11.82	BAX CASP8 FADD MCL1

Sources

GO Terms for Oral Cavity Cancer

Cellular components related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:0045121	9.67	CASP8 EGFR FADD TLR2
2	cell body	GO:0044297	9.58	CASP8 FADD TLR2
3	cytoplasm	GO:0005737	9.53	BAX CASP8 CYP1A1 EGFR ERBB2 FADD
4	death-inducing signaling complex	GO:0031264	9.32	CASP8 FADD
5	Bcl-2 family protein complex	GO:0097136	9.26	BAX MCL1
6	CD95 death-inducing signaling complex	GO:0031265	9.16	CASP8 FADD
7	ripoptosome	GO:0097342	8.96	CASP8 FADD

Biological processes related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

(show all 35)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:0008283	9.97	BAX CYP1A1 EGFR ERBB2 PTEN
2	apoptotic process	GO:0006915	9.91	BAX CASP8 FADD MCL1 PTEN TLR2
3	cytokine-mediated signaling pathway	GO:0019221	9.89	HSP90B1 MCL1 PIK3CA SOX2 VEGFA
4	response to hypoxia	GO:0001666	9.88	CYP1A1 HSP90B1 TLR2 VEGFA
5	positive regulation of protein kinase B signaling	GO:0051897	9.87	EGFR ERBB2 GDF15 PIK3CA
6	cell surface receptor signaling pathway	GO:0007166	9.85	CASP8 EGFR ERBB2 FADD TNFRSF10B
7	response to toxic substance	GO:0009636	9.84	BAX CYP1A1 TLR2
8	positive regulation of MAPK cascade	GO:0043410	9.83	EGFR ERBB2 GDF15 SOX2
9	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.82	EGFR PIK3CA VEGFA
10	liver development	GO:0001889	9.81	CYP1A1 EGFR PIK3CA
11	response to wounding	GO:0009611	9.8	BAX CYP1A1 SOX2
12	apoptotic signaling pathway	GO:0097190	9.79	BAX CASP8 FADD
13	positive regulation of epithelial cell proliferation	GO:0050679	9.79	EGFR ERBB2 VEGFA
14	positive regulation of MAP kinase activity	GO:0043406	9.78	EGFR ERBB2 VEGFA
15	extrinsic apoptotic signaling pathway	GO:0097191	9.73	BAX CASP8 FADD
16	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.71	BAX CASP8 FADD TNFRSF10B
17	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	9.69	CASP8 FADD TNFRSF10B
18	negative regulation of phagocytosis	GO:0050765	9.67	PTEN TLR2
19	activation of cysteine-type endopeptidase activity	GO:0097202	9.66	CASP8 FADD
20	positive regulation of macrophage differentiation	GO:0045651	9.65	CASP8 FADD
21	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043281	9.65	BAX SOX2
22	response to arsenic-containing substance	GO:0046685	9.65	CYP1A1 PTEN
23	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.65	BAX FADD MCL1
24	toll-like receptor 3 signaling pathway	GO:0034138	9.63	CASP8 FADD
25	regulation of apoptotic process	GO:0042981	9.63	BAX CASP8 FADD GDF15 MCL1 TNFRSF10B
26	death-inducing signaling complex assembly	GO:0071550	9.62	CASP8 FADD
27	cellular response to mechanical stimulus	GO:0071260	9.62	CASP8 EGFR FADD TNFRSF10B
28	ERBB2 signaling pathway	GO:0038128	9.61	EGFR ERBB2 PIK3CA
29	regulation of necroptotic process	GO:0060544	9.6	CASP8 FADD
30	negative regulation of ERBB signaling pathway	GO:1901185	9.59	EGFR ERBB2
31	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	9.55	BAX CASP8
32	regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902041	9.43	CASP8 FADD TNFRSF10B
33	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.26	BAX CASP8 FADD TNFRSF10B
34	TRAIL-activated apoptotic signaling pathway	GO:0036462	8.8	CASP8 FADD TNFRSF10B
35	negative regulation of apoptotic process	GO:0043066	10.01	EGFR ERBB2 HSP90B1 MCL1 PTEN VEGFA

Molecular functions related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.91	BAX CASP8 CYP1A1 EGFR ERBB2 FADD
2	protein heterodimerization activity	GO:0046982	9.63	BAX EGFR ERBB2 MCL1 TLR2 VEGFA
3	protein phosphatase binding	GO:0019903	9.58	EGFR ERBB2 HSP90B1
4	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.54	EGFR ERBB2 PIK3CA
5	death receptor binding	GO:0005123	9.46	CASP8 FADD
6	platelet-derived growth factor receptor binding	GO:0005161	9.43	PTEN VEGFA
7	BH3 domain binding	GO:0051434	9.32	BAX MCL1
8	death effector domain binding	GO:0035877	9.26	CASP8 FADD
9	identical protein binding	GO:0042802	9.23	BAX CASP8 EGFR ERBB2 FADD PTEN

Sources

Sources for Oral Cavity Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia