Oral Cavity Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ORL007 MIFTS: 61	Oral Cavity Cancer Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
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Aliases & Classifications for Oral Cavity Cancer

MalaCards integrated aliases for Oral Cavity Cancer:

Name: Oral Cavity Cancer ¹² ¹⁵

Malignant Neoplasm of Anterior Portion of Floor of Mouth ¹²

Malignant Neoplasm of Lateral Portion of Floor of Mouth ¹²

Malignant Neoplasm of Lateral Floor of Mouth ¹²

Malignant Tumor of Anterior Floor of Mouth ¹²

Malignant Tumor of Lateral Floor of Mouth ¹²

Malignant Tumor of the Floor of the Mouth ¹²

Malignant Neoplasm of Floor of Mouth ¹²

Malignant Tumor of Floor of Mouth ⁶

Neoplasm of the Oral Cavity ²⁹

Malignant Neoplasm of Mouth ⁷³

Oral Cavity Carcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of floor of mouth

Malignant neoplasm: Anterior floor of mouth

Malignant neoplasm: Floor of mouth, unspecified

Malignant neoplasm: Lateral floor of mouth

External Ids:

Disease Ontology ¹² DOID:8618

ICD10 ³³ C04 C04.0 C04.1 more

ICD9CM ³⁵ 144 144.0 144.1 more

NCIt ⁵⁰ C9318

SNOMED-CT ⁶⁸ 187652003 187653008 187656000 more

UMLS ⁷³ C0153368 C0153369 C0496758 more

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Summaries for Oral Cavity Cancer

Disease Ontology : ¹² A gastrointestinal system cancer that is located in the oral cavity.

MalaCards based summary : Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to salivary gland cancer and leukoplakia. An important gene associated with Oral Cavity Cancer is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, salivary gland and tongue, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

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Related Diseases for Oral Cavity Cancer

Diseases in the Oral Cavity Cancer family:

Oral Cavity Carcinoma in Situ

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)

#	Related Disease	Score	Top Affiliating Genes
1	salivary gland cancer	32.4	CASP8 EGFR ERBB2 PTEN
2	leukoplakia	31.1	CYP1A1 GSTM1 GSTT1
3	lip and oral cavity cancer	12.3
4	breast intraductal proliferative lesion	11.1	EGFR ERBB2
5	oral squamous cell carcinoma	11.0
6	geographic tongue	10.9	EGFR TNFRSF10B VEGFA
7	primary peritoneal carcinoma	10.9	EGFR ERBB2 VEGFA
8	intracystic papillary adenoma	10.9	EGFR ERBB2
9	breast carcinoma in situ	10.9	EGFR ERBB2 VEGFA
10	pharynx cancer	10.9	EGFR GSTM1 VEGFA
11	hearing loss, noise-induced	10.9	GSTM1 GSTT1
12	oral submucous fibrosis	10.9	CYP1A1 GSTM1 GSTT1
13	sister chromatid exchange, frequency of	10.8	ALDH2 GSTM1 GSTT1
14	progesterone-receptor negative breast cancer	10.8	EGFR ERBB2
15	breast squamous cell carcinoma	10.8	EGFR ERBB2 PIK3CA
16	adenosquamous cell lung carcinoma	10.8	EGFR ERBB2 PIK3CA
17	breast scirrhous carcinoma	10.8	EGFR ERBB2
18	mucinous stomach adenocarcinoma	10.8	PTEN VEGFA
19	oral cancer	10.8	CYP1A1 EGFR GSTM1 GSTT1
20	adult hepatocellular carcinoma	10.8	CASP8 PIK3CA
21	ovarian cancer 1	10.7	ERBB2 PIK3CA VEGFA
22	serous cystadenocarcinoma	10.7	ERBB2 PIK3CA VEGFA
23	estrogen-receptor positive breast cancer	10.7	EGFR ERBB2 PIK3CA
24	thyroid hurthle cell adenoma	10.7	PIK3CA PTEN
25	acneiform dermatitis	10.7	CYP1A1 EGFR ERBB2 PIK3CA
26	cystadenocarcinoma	10.7	ERBB2 PIK3CA VEGFA
27	grade iii astrocytoma	10.7	EGFR PTEN VEGFA
28	malignant ovarian surface epithelial-stromal neoplasm	10.7	EGFR ERBB2 PIK3CA VEGFA
29	ovary epithelial cancer	10.7	EGFR ERBB2 PIK3CA VEGFA
30	ovarian serous cystadenocarcinoma	10.7	ERBB2 PIK3CA VEGFA
31	endometrial adenocarcinoma	10.6	EGFR ERBB2 PTEN VEGFA
32	pancreas adenocarcinoma	10.6	EGFR ERBB2 PIK3CA VEGFA
33	acute lymphocytic leukemia	10.6	GSTM1 GSTT1 MCL1
34	bladder squamous cell carcinoma	10.6	ERBB2 PIK3CA PTEN
35	tobacco addiction	10.6	ALDH2 GSTM1 GSTT1
36	breast adenocarcinoma	10.5	CASP8 CYP1A1 EGFR ERBB2 PIK3CA
37	uterine carcinosarcoma	10.5	EGFR ERBB2 PIK3CA PTEN
38	renal cell carcinoma, papillary, 1	10.5	ERBB2 PIK3CA PTEN
39	cell type cancer	10.5	EGFR ERBB2 PTEN SOX2 VEGFA
40	cowden syndrome 1	10.5	EGFR PTEN
41	basal cell carcinoma	10.4	CYP1A1 GSTM1 GSTT1 PTEN
42	bladder cancer	10.4	EGFR ERBB2 GSTM1 GSTT1 VEGFA
43	female reproductive organ cancer	10.4	EGFR ERBB2 PIK3CA PTEN VEGFA
44	transitional cell carcinoma	10.4	EGFR ERBB2 PTEN
45	gastrointestinal system cancer	10.3	EGFR ERBB2 PIK3CA PTEN VEGFA
46	lung cancer susceptibility 3	10.3	CASP8 CYP1A1 EGFR ERBB2 PIK3CA VEGFA
47	glioblastoma multiforme	10.3	EGFR ERBB2 PIK3CA PTEN VEGFA
48	adenocarcinoma	10.3	EGFR ERBB2 PIK3CA PTEN VEGFA
49	larynx cancer	10.3	EGFR GSTM1 GSTT1
50	glioma	10.3	EGFR ERBB2 PIK3CA PTEN VEGFA

Comorbidity relations with Oral Cavity Cancer via Phenotypic Disease Network (PDN):

Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Oral Cavity Cancer:

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Symptoms & Phenotypes for Oral Cavity Cancer

GenomeRNAi Phenotypes related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance	GR00210-A	9.35	EGFR ERBB2 GSTM1 PTEN VEGFA
2	Decreased viability with paclitaxel	GR00179-A-1	8.92	EGFR ERBB2 FADD
3	Decreased viability with paclitaxel	GR00179-A-3	8.92	EGFR

MGI Mouse Phenotypes related to Oral Cavity Cancer:

⁴⁶ (show all 20)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.42	ALDH2 CYP1A1 EGFR CASP8 FADD LIN28B
2	cardiovascular system	MP:0005385	10.4	CYP1A1 EGFR CASP8 FADD LIN28B ERBB2
3	homeostasis/metabolism	MP:0005376	10.37	EGFR CASP8 CYP1A1 ALDH2 FADD LIN28B
4	cellular	MP:0005384	10.36	EGFR CASP8 ALDH2 HSP90B1 FADD ERBB2
5	mortality/aging	MP:0010768	10.36	ALDH2 CYP1A1 EGFR CASP8 FADD LIN28B
6	endocrine/exocrine gland	MP:0005379	10.34	CASP8 ALDH2 CYP1A1 EGFR FADD ERBB2
7	embryo	MP:0005380	10.31	CASP8 EGFR FADD LIN28B ERBB2 HSP90B1
8	immune system	MP:0005387	10.29	EGFR CASP8 CYP1A1 ALDH2 HSP90B1 FADD
9	hematopoietic system	MP:0005397	10.28	CASP8 EGFR CYP1A1 ALDH2 HSP90B1 FADD
10	integument	MP:0010771	10.19	EGFR CASP8 ALDH2 ERBB2 PIK3CA PTEN
11	digestive/alimentary	MP:0005381	10.18	EGFR FADD ERBB2 SHOX2 PTEN TLR2
12	nervous system	MP:0003631	10.18	EGFR CASP8 ALDH2 FADD LIN28B GDF15
13	liver/biliary system	MP:0005370	10.13	EGFR CASP8 CYP1A1 ALDH2 FADD GDF15
14	muscle	MP:0005369	10.13	EGFR CASP8 FADD LIN28B ERBB2 SOX2
15	neoplasm	MP:0002006	10.06	CASP8 ALDH2 EGFR ERBB2 SOX2 PTEN
16	normal	MP:0002873	9.91	EGFR CYP1A1 ERBB2 LIN28B MCL1 PTEN
17	no phenotypic analysis	MP:0003012	9.87	CYP1A1 HSP90B1 EGFR FADD PIK3CA SOX2
18	renal/urinary system	MP:0005367	9.7	CASP8 ALDH2 EGFR GDF15 PTEN TLR2
19	respiratory system	MP:0005388	9.5	CASP8 ERBB2 EGFR PTEN VEGFA TLR2
20	skeleton	MP:0005390	9.32	EGFR ALDH2 FADD ERBB2 SHOX2 PIK3CA

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Drugs & Therapeutics for Oral Cavity Cancer

Drugs for Oral Cavity Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 387)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Epinephrine

Approved, Vet_approved

Phase 4,Phase 2,Phase 1

51-43-4

5816

Racepinephrine

Approved

Phase 4,Phase 2,Phase 1

329-65-7

838

Dopexamine

Approved, Investigational

Phase 4

86197-47-9

55483

Nicotine

Approved

Phase 4,Not Applicable

54-11-5

942 89594

Dopamine

Approved

Phase 4,Phase 2

51-61-6, 62-31-7

681

Dobutamine

Approved

Phase 4,Not Applicable

34368-04-2

36811

Norepinephrine

Approved

Phase 4,Not Applicable

51-41-2

439260

Bupropion

Approved

Phase 4,Phase 2

34841-39-9, 34911-55-2

444

Edetic Acid

Approved, Vet_approved

Phase 4

60-00-4, 62-33-9

6049

Pentetic acid

Approved

Phase 4

67-43-6

protease inhibitors

Phase 4,Phase 2,Phase 3

Respiratory System Agents

Phase 4,Phase 2,Not Applicable

Adrenergic Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Adrenergic Agonists

Phase 4,Phase 2,Phase 3,Not Applicable

Adrenergic alpha-Agonists

Phase 4,Phase 2,Phase 3,Not Applicable

Chelating Agents

Phase 4,Not Applicable,Early Phase 1

Adrenergic beta-Agonists

Phase 4,Phase 2,Not Applicable

Mydriatics

Phase 4,Phase 2

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

HIV Protease Inhibitors

Phase 4,Phase 2,Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 2,Phase 3

Vasoconstrictor Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 2

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Epinephryl borate

Phase 4,Phase 2,Phase 1

Protective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Liver Extracts

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Radiopharmaceuticals

Phase 4,Phase 1,Phase 2,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Bronchodilator Agents

Phase 4,Phase 2

Dopamine agonists

Phase 4

Central Nervous System Stimulants

Phase 4,Phase 3,Not Applicable

Cholinergic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Technetium Tc 99m Pentetate

Phase 4

Technetium Tc 99m Sulfur Colloid

Phase 4,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4,Phase 2

Nicotinic Agonists

Phase 4,Not Applicable

Dextrans

Phase 4

Dopamine Agents

Phase 4,Phase 2

Vasodilator Agents

Phase 4,Not Applicable

Dopamine Uptake Inhibitors

Phase 4,Phase 2

Plasma Substitutes

Phase 4

Anticoagulants

Phase 4,Not Applicable

Antidepressive Agents

Phase 4,Phase 3,Phase 2

Antidepressive Agents, Second-Generation

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 3,Phase 2

Blood Substitutes

Phase 4

Calcium, Dietary

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

diuretics

Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 545)

#	Name	Status	NCT ID	Phase	Drugs
1	Stereotactic Body Radiotherapy for Head and Neck Tumors	Unknown status	NCT01344356	Phase 4
2	Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery	Completed	NCT01418118	Phase 4	Epinephrine;Norepinephrine;Dobutamine;Dopexamine
3	Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer	Completed	NCT02287675	Phase 4	Lymphoseek;Sulfur Colloid
4	Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking	Completed	NCT00666978	Phase 4	bupropion hydrochloride
5	Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking	Completed	NCT00365508	Phase 4	nicotine lozenge;nicotine patch
6	Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia	Completed	NCT00155337	Phase 4
7	The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor	Recruiting	NCT03017053	Phase 4
8	Aliskiren Study of Safety and Efficacy in Senior Hypertensives	Withdrawn	NCT01922141	Phase 4	Aliskiren;Amlodipine;Ramipril;Hydrochlorothiazide
9	Oral Cancer Screening in Mumbai, India by Primary Health Care Workers	Unknown status	NCT00655421	Phase 3
10	Oral Cancer Adjuvant Therapy (OCAT) Trial	Unknown status	NCT00193843	Phase 3
11	Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL	Unknown status	NCT01039298	Phase 3
12	Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer	Unknown status	NCT00002747	Phase 3	cisplatin;fluorouracil
13	Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx	Unknown status	NCT00002702	Phase 3
14	Trial of IIb Preserving Neck Dissection	Unknown status	NCT00847717	Phase 3
15	The Feasibility of Dexmedetomidine for Awake Fiberoptic Nasal Intubation	Unknown status	NCT00815893	Phase 2, Phase 3	dexmedetomidine;Normal Saline 0.9%;propofol 1%
16	Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer	Unknown status	NCT00022373	Phase 3	iseganan HCl oral solution
17	PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer	Unknown status	NCT00720070	Phase 3
18	Study of I-125 Brachytherapy Versus Intensity-modulated Radiation Therapy to Treat Inoperable Salivary Gland Cancer	Unknown status	NCT02048254	Phase 3
19	Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors	Unknown status	NCT01216800	Phase 3
20	Workplace Tobacco Cessation And Oral Cancer Screening Study	Completed	NCT00750503	Phase 3
21	Post-Operative Adjuvant Concurrent Chemoradiotherapy For High Risk Oral Cavity Squamous Cell Carcinoma Patients	Completed	NCT00201383	Phase 3	cisplatin
22	Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity	Completed	NCT01265849	Phase 3
23	Oral Mucositis in Patients Receiving Radiation Therapy for Cancer of the Mouth, Pharynx, or Larynx	Completed	NCT00004234	Phase 3
24	Phase II Trial of Allovectin-7® for Head and Neck Cancer	Completed	NCT00050388	Phase 3
25	Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma	Completed	NCT00201279	Phase 3	13-cis Retino Acid
26	Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer	Completed	NCT01434394	Phase 2, Phase 3	Neo-adjuvant Erbitux-based chemotherapy
27	Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population	Completed	NCT00359645	Phase 3
28	Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC	Completed	NCT00158652	Phase 3	5FU, Paraplatin
29	Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC	Completed	NCT00162708	Phase 2, Phase 3	CDDP, 5 Fu
30	Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer	Completed	NCT00008398	Phase 3
31	Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy	Completed	NCT01156142	Phase 3	doxepin hydrochloride
32	Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Completed	NCT00538850	Phase 3	Fentanyl sublingual spray;Placebo
33	Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract	Completed	NCT00765440	Phase 3
34	Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer	Completed	NCT00090337	Phase 3
35	Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Completed	NCT00002533	Phase 2, Phase 3	fluconazole
36	Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer	Completed	NCT00017511	Phase 3	cevimeline hydrochloride
37	Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer	Completed	NCT00006799	Phase 3	megestrol acetate
38	Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer	Completed	NCT00002507	Phase 3	mitomycin C;porfiromycin
39	Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer	Completed	NCT00002476	Phase 3	fluorouracil;leucovorin calcium;methotrexate;vincristine sulfate
40	Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Completed	NCT00656513	Phase 2, Phase 3	Pilocarpine
41	Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer	Completed	NCT00820248	Phase 3	cisplatin
42	The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome	Completed	NCT01414790	Phase 3
43	Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.	Recruiting	NCT00964977	Phase 3
44	DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer	Recruiting	NCT03237325	Phase 3	SGX942;Placebo
45	Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers	Recruiting	NCT02868151	Phase 2, Phase 3	Ascorbic Acid;Zinc acetate
46	Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck	Recruiting	NCT02236936	Phase 3	Cisplatin
47	Erlotinib Prevention of Oral Cancer (EPOC)	Active, not recruiting	NCT00402779	Phase 3	Erlotinib;Placebo
48	IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC	Active, not recruiting	NCT00158678	Phase 3	concomitant cisplatin
49	Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma	Active, not recruiting	NCT00588770	Phase 3	Carboplatin;Cisplatin;Docetaxel;Fluorouracil
50	Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer	Active, not recruiting	NCT01810913	Phase 2, Phase 3	cisplatin;docetaxel

Search NIH Clinical Center for Oral Cavity Cancer

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Genetic Tests for Oral Cavity Cancer

Genetic tests related to Oral Cavity Cancer:

#	Genetic test	Affiliating Genes
1	Neoplasm of the Oral Cavity ²⁹

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Anatomical Context for Oral Cavity Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Oral Cavity Cancer:

¹⁹

The Oral Cavity

MalaCards organs/tissues related to Oral Cavity Cancer:

⁴¹

Salivary Gland, Tongue, Lymph Node, Lung, Skin, Brain, Testes

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Publications for Oral Cavity Cancer

Articles related to Oral Cavity Cancer:

(show top 50) (show all 301)

#	Title	Authors	Year
1	Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience. ( 29706184 )	Foster C.C....Haraf D.J.	2018
2	Association of Time between Surgery and Adjuvant Therapy with Survival in Oral Cavity Cancer. ( 29313448 )	Chen M.M....Divi V.	2018
3	Detection of surgical margins in oral cavity cancer: the role of dynamic optical contrast imaging. ( 29517537 )	Pellionisz P.A....St John M.A.	2018
4	Low expression of CD40L in tumor-free lymph node of oral cavity cancer related with poor prognosis. ( 29761306 )	Rah Y.C....Ahn S.H.	2018
5	Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins? ( 29790687 )	Strzelczyk J.K....Owczarek A.J.	2018
6	Locoregionally advanced oral cavity cancer: A propensity-score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy. ( 29665118 )	Shin J.Y....Diaz A.Z.	2018
7	The influence of insurance status on treatment and outcomes in oral cavity cancer: an analysis on 46,373 patients. ( 29655817 )	Shin J.Y....Diaz A.Z.	2018
8	MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: Preliminary clinical study. ( 29633413 )	Bae S....Kim J.	2018
9	The influence of marital status on survival for patients aged 65 years and younger with oral cavity cancer. ( 29685504 )	Liao P.H....Lee C.C.	2018
10	The effectiveness of a saline mouth rinse regimen and education programme on radiation-induced oral mucositis and quality of life in oral cavity cancer patients: A randomised controlled trial. ( 29315944 )	Huang B.S....Chen S.C.	2018
11	Effects of a swallowing exercise education program on dysphagia-specific health-related quality of life in oral cavity cancer patients post-treatment: a randomized controlled trial. ( 29546525 )	Chen S.C....Wu S.C.	2018
12	Opioid prescribing practices in patients undergoing surgery for oral cavity cancer. ( 29756393 )	Pang J....Coffey C.S.	2018
13	Genetic analysis of surgical margins in oral cavity cancer. ( 29341160 )	Liu S.A....Lin J.C.	2018
14	Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival. ( 29480612 )	Farah C.S.	2018
15	Aberrant DNA methylation of the <i>p16, APC, MGMT, TIMP3</i> and <i>CDH1</i> gene promoters in tumours and the surgical margins of patients with oral cavity cancer. ( 29896273 )	Strzelczyk J.K....Owczarek A.J.	2018
16	Diagnostic Pathway of Oral Cavity Cancer in an Integrated Health Care System. ( 29616906 )	Wang K.H....Gurushanthaiah D.	2018
17	Can MR textural analysis improve the prediction of extracapsular nodal spread in patients with oral cavity cancer? ( 29872911 )	Frood R....Scarsbrook A.	2018
18	Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system. ( 29739969 )	Dong F....Lyu P.	2018
19	High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands. ( 29575685 )	Boeve K....Witjes M.J.H.	2018
20	Untreated oral cavity cancer: Long-term survival and factors associated with treatment refusal. ( 28865100 )	Cheraghlou S....Judson B.L.	2017
21	Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer. ( 28880746 )	Ho A.S....Zumsteg Z.S.	2017
22	Recent Trends in Oral Cavity Cancer Research Support in the United States. ( 28033064 )	Fribley A.M....Kirkwood K.L.	2017
23	Comparison of facility type outcomes for oral cavity cancer: Analysis of the national cancer database. ( 28671267 )	Rubin S.J....Jalisi S.	2017
24	Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis. ( 28426848 )	Spiotto M.T....Koshy M.	2017
25	Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow. ( 28806994 )	Mohamed A.S.R....Garden A.S.	2017
26	Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer. ( 29257122 )	Drop B....Polz-Dacewicz M.	2017
27	Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy. ( 28797467 )	Quinlan-Davidson S.R....Garden A.S.	2017
28	Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery. ( 28321535 )	Tangthongkum M....Leelasawatsuk P.	2017
29	What additional treatment is indicated for oral cavity cancer with isolated perineural invasion? ( 28349551 )	Hatten K.M....Strome S.E.	2017
30	Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer. ( 28448645 )	Tam S....Nichols A.C.	2017
31	Factors associated with continued smoking after treatment of oral cavity cancer: An age and survival time-matched study. ( 29148210 )	Chang S.L....Chen S.C.	2017
32	Frequency of Depression and its Correlation with Quality of Life of Patients with Oral Cavity Cancer. ( 28883770 )	Dzebo S....Foco F.	2017
33	Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer. ( 28838425 )	Hosni A....Hope A.	2017
34	Chronic Opioid Use Following Surgery for Oral Cavity Cancer. ( 28445584 )	Pang J....Califano J.A.	2017
35	Prognostic implication of ERCC1 protein expression in resected oropharynx and oral cavity cancer. ( 28645807 )	An H.J....Ko Y.H.	2017
36	Primary Surgery vs Radiotherapy for Early Stage Oral Cavity Cancer. ( 29256326 )	Ellis M.A....Day T.A.	2017
37	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites - A singe institute's experience in Taiwan. ( 28785002 )	Liu S.A....Lin J.C.	2017
38	Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. ( 28421310 )	Strzelczyk J.K....Ostrowska Z.	2017
39	Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study. ( 28388649 )	Tsai W.C....Liu S.A.	2017
40	Quality Metrics in Oral Cavity Cancer-Developing Standards for Optimal Lymph Node Yield. ( 28715525 )	St Clair J.M.	2017
41	Conditional relative survival of oral cavity cancer: Based on Korean Central Cancer Registry. ( 28797465 )	Min S.K....Jung K.W.	2017
42	Surgical site infections following oral cavity cancer resection and reconstruction is a risk factor for plate exposure. ( 28390434 )	Yao C.M....de Almeida J.R.	2017
43	Quality of Life of Patients with Oral Cavity Cancer. ( 28484351 )	Dzebo S....Erkocevic H.	2017
44	Individualized risk prediction of outcomes for oral cavity cancer patients. ( 27939002 )	Prince V....Taylor J.M.	2016
45	Electronic Cigarette: Role in the Primary Prevention of Oral Cavity Cancer. ( 27773997 )	Franco T....Allegra E.	2016
46	Impact of microsatellite alteration in surgical margins on local recurrence in oral cavity cancer patients. ( 27430224 )	Lin J.C....Liu S.A.	2016
47	Neck dissection and stroke in patients with oral cavity cancer: A population-based cohort study. ( 27439202 )	Chang C.F....Chou Y.J.	2016
48	CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer. ( 28059707 )	Junn J.C....Aiken A.H.	2016
49	High-Volume Surgeons Deliver Larger Surgical Margins in Oral Cavity Cancer. ( 26896758 )	Ellis O.G....Batstone M.D.	2016
50	Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment-a Pilot Study from Northern India. ( 27872524 )	Singh A.K....Singh S.	2016

Sources

Genes for Oral Cavity Cancer

Genes related to Oral Cavity Cancer (1 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	405.05	Pathogenic ⁶ DISEASES inferred ¹⁵
2	PTEN	Phosphatase And Tensin Homolog	Protein Coding	29.86	Pathogenic/Likely pathogenic ⁶ DISEASES inferred ¹⁵
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	23.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	22.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	22.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	21.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CASP8	Caspase 8	Protein Coding	21.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	FADD	Fas Associated Via Death Domain	Protein Coding	21.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	SOX2	SRY-Box 2	Protein Coding	21.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	MCL1	MCL1, BCL2 Family Apoptosis Regulator	Protein Coding	21.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	LIN28B	Lin-28 Homolog B	Protein Coding	20.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	GDF15	Growth Differentiation Factor 15	Protein Coding	20.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	20.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	20.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	TLR2	Toll Like Receptor 2	Protein Coding	20.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	19.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	SHOX2	Short Stature Homeobox 2	Protein Coding	18.27	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
20	TECR	Trans-2,3-Enoyl-CoA Reductase	Protein Coding	18.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
21	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
22	DNAJB7	DnaJ Heat Shock Protein Family (Hsp40) Member B7	Protein Coding	8.49	DISEASES inferred ¹⁵
23	AREG	Amphiregulin	Protein Coding	7.71	DISEASES inferred ¹⁵ ¹⁵
24	MAU2	MAU2 Sister Chromatid Cohesion Factor	Protein Coding	7.66	DISEASES inferred ¹⁵
25	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	7.61	DISEASES inferred ¹⁵
26	TP53	Tumor Protein P53	Protein Coding	7.27	DISEASES inferred ¹⁵
27	ISL1	ISL LIM Homeobox 1	Protein Coding	7.1	DISEASES inferred ¹⁵
28	CDH1	Cadherin 1	Protein Coding	6.89	DISEASES inferred ¹⁵
29	GPX1	Glutathione Peroxidase 1	Protein Coding	6.78	GeneCards inferred via : Publications (show sections)
30	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	6.78	GeneCards inferred via : Publications (show sections)
31	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	6.78	GeneCards inferred via : Publications (show sections)

Sources

Variations for Oral Cavity Cancer

ClinVar genetic disease variations for Oral Cavity Cancer:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PIK3CA	NM_006218.3(PIK3CA): c.3139C> T (p.His1047Tyr)	single nucleotide variant	Pathogenic	rs121913281	GRCh37	Chromosome 3, 178952084: 178952084
2	PIK3CA	NM_006218.3(PIK3CA): c.3139C> T (p.His1047Tyr)	single nucleotide variant	Pathogenic	rs121913281	GRCh38	Chromosome 3, 179234296: 179234296
3	PTEN	NM_000314.6(PTEN): c.388C> G (p.Arg130Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121909224	GRCh37	Chromosome 10, 89692904: 89692904
4	PTEN	NM_000314.6(PTEN): c.388C> G (p.Arg130Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121909224	GRCh38	Chromosome 10, 87933147: 87933147
5	PIK3CA	NM_006218.3(PIK3CA): c.3145G> C (p.Gly1049Arg)	single nucleotide variant	Likely pathogenic	rs121913277	GRCh38	Chromosome 3, 179234302: 179234302
6	PIK3CA	NM_006218.3(PIK3CA): c.3145G> C (p.Gly1049Arg)	single nucleotide variant	Likely pathogenic	rs121913277	GRCh37	Chromosome 3, 178952090: 178952090

Sources

Expression for Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Sources

Pathways for Oral Cavity Cancer

Pathways related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

(show all 43)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.02	CASP8 EGFR ERBB2 FADD HSP90B1 MCL1
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.38	EGFR ERBB2 FADD GDF15 PTEN TLR2
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.32	EGFR ERBB2 HSP90B1 MCL1 PIK3CA SOX2
4	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.81	EGFR ERBB2 HSP90B1 PIK3CA PTEN VEGFA
5	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁷ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁵ Death Receptor Signaling ⁶⁷	12.76	CASP8 FADD MCL1 PIK3CA TNFRSF10B
6	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.74	CASP8 FADD PIK3CA TLR2 TNFRSF10B
7	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.72	EGFR ERBB2 PIK3CA PTEN VEGFA
8	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.71	EGFR ERBB2 GSTM1 GSTT1 PIK3CA PTEN
9	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.68	CASP8 EGFR ERBB2 FADD HSP90B1 MCL1
10	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.47	CASP8 FADD PIK3CA PTEN TLR2 VEGFA
11	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.45	EGFR ERBB2 PIK3CA PTEN
12	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁷ Inflammatory mediator regulation of TRP channels ³⁷	12.45	CASP8 EGFR FADD PIK3CA PTEN TNFRSF10B
13	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.43	EGFR ERBB2 PIK3CA VEGFA
14	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.4	CASP8 EGFR ERBB2 PIK3CA
15	MicroRNAs in cancer ³⁷	12.39	EGFR ERBB2 MCL1 PIK3CA PTEN VEGFA
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.28	CASP8 FADD HSP90B1 TLR2
17	Regulation by c-FLIP ⁶⁶ Show member pathways CASP8 activity is inhibited ⁶⁶ Caspase activation via extrinsic apoptotic signalling pathway ⁶⁶ Dimerization of procaspase-8 ⁶⁶ FAS (CD95) signaling pathway ¹ Ligand-dependent caspase activation ⁶⁶ Ligand-independent caspase activation via DCC ⁶⁶ Regulated Necrosis ⁶⁶ Regulation of necroptotic cell death ⁶⁶ RIPK1-mediated regulated necrosis ⁶⁶ TRAIL signaling ⁶⁶ TRAIL signaling pathway ¹	12.24	CASP8 FADD PIK3CA TNFRSF10B
18	Proteoglycans in cancer ³⁷	12.23	EGFR ERBB2 PIK3CA TLR2 VEGFA
19	Apoptosis and Autophagy ⁴	12.18	CASP8 FADD GDF15 MCL1 TNFRSF10B
20	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.1	EGFR ERBB2 PIK3CA PTEN
21	AKT Signaling Pathway ⁶⁷	12.09	EGFR ERBB2 HSP90B1 PIK3CA PTEN
22	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.06	EGFR ERBB2 PIK3CA PTEN
23	Integrated Breast Cancer Pathway ¹	12.04	CASP8 EGFR FADD PTEN VEGFA
24	Pathways in cancer ³⁷	12.04	CASP8 EGFR ERBB2 FADD GSTM1 GSTT1
25	Fluid shear stress and atherosclerosis ³⁷	11.94	GSTM1 GSTT1 HSP90B1 PIK3CA VEGFA
26	Interleukin-4 and 13 signaling ⁶⁶	11.93	HSP90B1 MCL1 SOX2 VEGFA
27	Direct p53 effectors ¹	11.89	EGFR GDF15 MCL1 PTEN TNFRSF10B
28	HIF-1 signaling pathway ³⁷	11.86	EGFR ERBB2 PIK3CA VEGFA
29	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.83	CASP8 EGFR ERBB2 HSP90B1 PIK3CA TLR2
30	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.82	EGFR ERBB2 VEGFA
31	IL6-mediated signaling events ¹ Show member pathways IL-6 signaling pathway ¹	11.78	HSP90B1 MCL1 PIK3CA
32	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ Apoptosis - multiple species ³⁷ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶	11.77	CASP8 FADD MCL1
33	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶¹ Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²² Acetaminophen metabolism ²² Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶¹	11.73	CYP1A1 GSTM1 GSTT1
34	Bladder cancer ³⁷ ¹	11.69	EGFR ERBB2 VEGFA
35	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.63	ERBB2 PIK3CA PTEN
36	Central carbon metabolism in cancer ³⁷	11.61	EGFR ERBB2 PIK3CA PTEN
37	Aryl Hydrocarbon Receptor ¹	11.49	CYP1A1 EGFR VEGFA
38	Integrins in angiogenesis ¹	11.46	CASP8 PIK3CA VEGFA
39	all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴	11.41	CASP8 FADD TNFRSF10B
40	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁶	11.4	EGFR PIK3CA VEGFA
41	Platinum drug resistance ³⁷	11.3	CASP8 ERBB2 FADD GSTM1 GSTT1 PIK3CA
42	a6b1 and a6b4 Integrin signaling ¹	11.25	EGFR ERBB2 PIK3CA
43	Naphthalene metabolism ²²	11.1	CYP1A1 GSTM1 GSTT1

Sources

GO Terms for Oral Cavity Cancer

Cellular components related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:0045121	9.62	CASP8 EGFR FADD TLR2
2	cell body	GO:0044297	9.54	CASP8 FADD TLR2
3	cytoplasm	GO:0005737	9.53	CASP8 CYP1A1 EGFR ERBB2 FADD GDF15
4	death-inducing signaling complex	GO:0031264	9.26	CASP8 FADD
5	CD95 death-inducing signaling complex	GO:0031265	9.16	CASP8 FADD
6	ripoptosome	GO:0097342	8.96	CASP8 FADD

Biological processes related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.93	EGFR ERBB2 HSP90B1 MCL1 PTEN VEGFA
2	regulation of apoptotic process	GO:0042981	9.89	CASP8 FADD GDF15 MCL1 TNFRSF10B
3	cytokine-mediated signaling pathway	GO:0019221	9.88	HSP90B1 MCL1 PIK3CA SOX2 VEGFA
4	response to lipopolysaccharide	GO:0032496	9.85	CASP8 CYP1A1 TLR2 TNFRSF10B
5	response to estradiol	GO:0032355	9.83	CASP8 EGFR PTEN
6	response to hypoxia	GO:0001666	9.83	CYP1A1 HSP90B1 TLR2 VEGFA
7	positive regulation of MAPK cascade	GO:0043410	9.81	EGFR ERBB2 SOX2 TNFRSF10B
8	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.8	CASP8 FADD TNFRSF10B
9	liver development	GO:0001889	9.79	CYP1A1 EGFR PIK3CA
10	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.78	EGFR PIK3CA VEGFA
11	apoptotic signaling pathway	GO:0097190	9.77	CASP8 FADD TNFRSF10B
12	positive regulation of MAP kinase activity	GO:0043406	9.74	EGFR ERBB2 VEGFA
13	positive regulation of epithelial cell proliferation	GO:0050679	9.73	EGFR ERBB2 VEGFA
14	cell surface receptor signaling pathway	GO:0007166	9.72	CASP8 EGFR ERBB2 FADD TNFRSF10B
15	negative regulation of ERBB signaling pathway	GO:1901185	9.65	EGFR ERBB2
16	positive regulation of macrophage differentiation	GO:0045651	9.64	CASP8 FADD
17	activation of cysteine-type endopeptidase activity	GO:0097202	9.64	CASP8 FADD
18	response to arsenic-containing substance	GO:0046685	9.63	CYP1A1 PTEN
19	negative regulation of phagocytosis	GO:0050765	9.63	PTEN TLR2
20	regulation of necroptotic process	GO:0060544	9.61	CASP8 FADD
21	ERBB2 signaling pathway	GO:0038128	9.61	EGFR ERBB2 PIK3CA
22	toll-like receptor 3 signaling pathway	GO:0034138	9.59	CASP8 FADD
23	death-inducing signaling complex assembly	GO:0071550	9.58	CASP8 FADD
24	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	9.58	CASP8 FADD TNFRSF10B
25	cellular response to mechanical stimulus	GO:0071260	9.46	CASP8 EGFR FADD TNFRSF10B
26	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.43	CASP8 FADD TNFRSF10B
27	TRAIL-activated apoptotic signaling pathway	GO:0036462	9.37	CASP8 FADD
28	regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902041	9.13	CASP8 FADD TNFRSF10B
29	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	8.8	CASP8 FADD TNFRSF10B
30	multicellular organism development	GO:0007275	10.13	EGFR ERBB2 MCL1 SHOX2 SOX2 TNFRSF10B
31	apoptotic process	GO:0006915	10.01	CASP8 FADD MCL1 PTEN TLR2 TNFRSF10B

Molecular functions related to Oral Cavity Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.91	CASP8 CYP1A1 EGFR ERBB2 FADD GDF15
2	protein heterodimerization activity	GO:0046982	9.77	EGFR ERBB2 MCL1 TLR2 VEGFA
3	platelet-derived growth factor receptor binding	GO:0005161	9.43	PTEN VEGFA
4	protein phosphatase binding	GO:0019903	9.43	EGFR ERBB2 HSP90B1
5	death receptor binding	GO:0005123	9.4	CASP8 FADD
6	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.33	EGFR ERBB2 PIK3CA
7	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	GO:0004716	9.32	EGFR ERBB2
8	death effector domain binding	GO:0035877	8.62	CASP8 FADD

Sources

Sources for Oral Cavity Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia