MCID: ORL022
MIFTS: 36

Oral Erosive Lichen

Categories: Skin diseases, Rare diseases, Oral diseases

Aliases & Classifications for Oral Erosive Lichen

MalaCards integrated aliases for Oral Erosive Lichen:

Name: Oral Erosive Lichen 59

Classifications:

Orphanet: 59  
Rare skin diseases


Summaries for Oral Erosive Lichen

MalaCards based summary : Oral Erosive Lichen is related to hepatitis c and lichen planus. An important gene associated with Oral Erosive Lichen is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and PI3K-Akt signaling pathway. The drugs Tacrolimus and Pimecrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are oral ulcer and dry skin

Related Diseases for Oral Erosive Lichen

Graphical network of the top 20 diseases related to Oral Erosive Lichen:



Diseases related to Oral Erosive Lichen

Symptoms & Phenotypes for Oral Erosive Lichen

Human phenotypes related to Oral Erosive Lichen:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 oral ulcer 59 32 hallmark (90%) Very frequent (99-80%) HP:0000155
2 dry skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0000958
3 abnormal blistering of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0008066
4 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
5 lichenification 59 32 hallmark (90%) Very frequent (99-80%) HP:0100725
6 cheilitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100825

Drugs & Therapeutics for Oral Erosive Lichen

Drugs for Oral Erosive Lichen (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
2
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
3 Analgesics Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Dermatologic Agents Phase 2
6 Peripheral Nervous System Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Anti-Inflammatory Agents Phase 2
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2
10 Antirheumatic Agents Phase 2
11 Calcineurin Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
2 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2 1% pimecrolimus cream

Search NIH Clinical Center for Oral Erosive Lichen

Genetic Tests for Oral Erosive Lichen

Anatomical Context for Oral Erosive Lichen

MalaCards organs/tissues related to Oral Erosive Lichen:

41
Skin, Liver

Publications for Oral Erosive Lichen

Articles related to Oral Erosive Lichen:

(show all 31)
# Title Authors Year
1
Evaluation of photodynamic therapy in treatment of oral erosive lichen planus in comparison with topically applied corticosteroids. ( 28450262 )
2017
2
Antimalarial Drugs for the Treatment of Oral Erosive Lichen Planus. ( 26445088 )
2015
3
Clinical diagnosis of oral erosive lichen planus by direct oral microscopy. ( 25254007 )
2014
4
Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8A week randomized double-blind controlled study. ( 23451852 )
2013
5
Oral erosive lichen planus associated with thymoma treated with etretinate. ( 23373893 )
2013
6
Pimecrolimus 1% cream for oral erosive lichen planus: a 6-week randomized, double-blind, vehicle-controlled study with a 6-week open-label extension to assess efficacy and safety. ( 21175873 )
2011
7
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). ( 21282092 )
2011
8
Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases. ( 18997452 )
2009
9
Oral erosive lichen planus and Good's syndrome: just a coincidence or a direct link between the two diseases? ( 18363920 )
2008
10
A single-center, open-label, prospective pilot study of subcutaneous efalizumab for oral erosive lichen planus. ( 17373193 )
2007
11
Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. ( 17438179 )
2007
12
Oral erosive lichen planus regression after thymoma resection. ( 17307497 )
2007
13
Successful treatment of oral erosive lichen planus with mycophenolate mofetil. ( 17243970 )
2007
14
Oral erosive lichen planus treated with efalizumab. ( 16785369 )
2006
15
Psychological health in patients with genital and oral erosive lichen planus. ( 16836492 )
2006
16
Topic tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids: a case report. ( 17072247 )
2006
17
The effectiveness of 1% pimecrolimus cream in the treatment of oral erosive lichen planus. ( 15857105 )
2005
18
Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C. ( 15647837 )
2005
19
Erythematosus actinic lichen planus: a new clinical form associated with oral erosive lichen planus and chronic active hepatitis B. ( 12410730 )
2002
20
Oral erosive lichen planus associated with thymoma. ( 11903672 )
2001
21
Effective treatment of oral erosive lichen planus with thalidomide. ( 11115153 )
2000
22
Oral erosive lichen planus with epidermolytic hyperkeratosis during interferon alfa-2b therapy for chronic hepatitis C virus infection. ( 9204077 )
1997
23
Appearance of oral erosive lichen planus during interferon alfa-2a therapy for chronic active hepatitis C. ( 7650248 )
1995
24
Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. ( 7552878 )
1995
25
Hepatitis C virus infection and oral erosive lichen planus. ( 7798440 )
1994
26
Serologic and molecular analysis of the HLA system in Israeli Jewish patients with oral erosive lichen planus. ( 8085257 )
1994
27
Treatment of localized oral erosive lichen planus lesions with free soft tissue grafts. ( 3507707 )
1987
28
Treatment of oral erosive lichen planus with systemic isotretinoin. ( 3464912 )
1986
29
Oral erosive lichen planus and chronic liver disease. ( 3950105 )
1986
30
Oral erosive lichen planus and chronic active hepatitis. ( 3989029 )
1985
31
Griseofulvin in the treatment of three cases of oral erosive lichen planus. ( 6575336 )
1983

Variations for Oral Erosive Lichen

Expression for Oral Erosive Lichen

Search GEO for disease gene expression data for Oral Erosive Lichen.

Pathways for Oral Erosive Lichen

Pathways related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 IFNA1 IFNB1
2
Show member pathways
12.36 IFNA1 IFNB1
3
Show member pathways
12.21 IFNA1 IFNB1
4
Show member pathways
12.18 IFNA1 IFNB1
5
Show member pathways
12.05 IFNA1 IFNB1
6
Show member pathways
12.01 IFNA1 IFNB1
7
Show member pathways
11.97 IFNA1 IFNB1
8
Show member pathways
11.91 IFNA1 IFNB1
9
Show member pathways
11.71 IFNA1 IFNB1
10 11.62 IFNA1 IFNB1
11
Show member pathways
11.56 IFNA1 IFNB1
12 11.45 IFNA1 IFNB1
13 11.1 IFNA1 IFNB1
14 11.07 IFNA1 IFNB1
15 10.25 IFNA1 IFNB1

GO Terms for Oral Erosive Lichen

Biological processes related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.55 IFNA1 IFNB1
2 cytokine-mediated signaling pathway GO:0019221 9.54 IFNA1 IFNB1
3 adaptive immune response GO:0002250 9.52 IFNA1 IFNB1
4 blood coagulation GO:0007596 9.51 IFNA1 IFNB1
5 defense response to virus GO:0051607 9.49 IFNA1 IFNB1
6 defense response GO:0006952 9.48 IFNA1 IFNB1
7 B cell differentiation GO:0030183 9.46 IFNA1 IFNB1
8 type I interferon signaling pathway GO:0060337 9.43 IFNA1 IFNB1
9 humoral immune response GO:0006959 9.4 IFNA1 IFNB1
10 response to exogenous dsRNA GO:0043330 9.37 IFNA1 IFNB1
11 B cell proliferation GO:0042100 9.32 IFNA1 IFNB1
12 regulation of type I interferon-mediated signaling pathway GO:0060338 9.26 IFNA1 IFNB1
13 T cell activation involved in immune response GO:0002286 9.16 IFNA1 IFNB1
14 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 8.96 IFNA1 IFNB1
15 natural killer cell activation involved in immune response GO:0002323 8.62 IFNA1 IFNB1

Molecular functions related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.16 IFNA1 IFNB1
2 cytokine receptor binding GO:0005126 8.96 IFNA1 IFNB1
3 type I interferon receptor binding GO:0005132 8.62 IFNA1 IFNB1

Sources for Oral Erosive Lichen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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