MCID: ORL022
MIFTS: 30

Oral Erosive Lichen

Categories: Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Oral Erosive Lichen

MalaCards integrated aliases for Oral Erosive Lichen:

Name: Oral Erosive Lichen 58

Classifications:

Orphanet: 58  
Rare skin diseases


Summaries for Oral Erosive Lichen

MalaCards based summary : Oral Erosive Lichen is related to lichen planus and oral lichen planus. An important gene associated with Oral Erosive Lichen is IFNA1 (Interferon Alpha 1), and among its related pathways/superpathways are Measles and Herpes simplex virus 1 infection. The drugs Pimecrolimus and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Related phenotypes are dry skin and cheilitis

Related Diseases for Oral Erosive Lichen

Diseases related to Oral Erosive Lichen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 lichen planus 10.8
2 oral lichen planus 10.5
3 thymoma, familial 10.4
4 thymoma 10.4
5 hepatitis c virus 10.3
6 agammaglobulinemia 10.2
7 epidermolytic hyperkeratosis 10.0
8 cd4/cd8 t-cell ratio 10.0
9 graft-versus-host disease 10.0
10 good syndrome 10.0
11 primary biliary cholangitis 10.0
12 oral candidiasis 10.0
13 candidiasis 10.0
14 urticaria 10.0
15 keratosis 10.0
16 liver disease 10.0
17 lymphopenia 10.0
18 alopecia areata 10.0
19 alopecia 10.0
20 actinic lichen planus 10.0
21 chronic graft versus host disease 10.0
22 leukoplakia 10.0
23 autosomal dominant epidermolytic ichthyosis 10.0
24 parainfluenza virus type 3 9.9 IFNB1 IFNA1
25 influenza 9.9 IFNB1 IFNA1
26 ebola hemorrhagic fever 9.9 IFNB1 IFNA1
27 swine influenza 9.9 IFNB1 IFNA1
28 anogenital venereal wart 9.9 IFNB1 IFNA1
29 penile disease 9.9 IFNB1 IFNA1
30 chickenpox 9.9 IFNB1 IFNA1
31 crimean-congo hemorrhagic fever 9.9 IFNB1 IFNA1
32 herpangina 9.9 IFNB1 IFNA1
33 venezuelan equine encephalitis 9.9 IFNB1 IFNA1
34 chilblain lupus 1 9.9 IFNB1 IFNA1
35 coronavirus infectious disease 9.9 IFNB1 IFNA1
36 viral encephalitis 9.9 IFNB1 IFNA1
37 tick-borne encephalitis 9.9 IFNB1 IFNA1
38 microphthalmia with limb anomalies 9.9 IFNB1 IFNA1
39 newcastle disease 9.9 IFNB1 IFNA1
40 dengue hemorrhagic fever 9.9 IFNB1 IFNA1
41 dengue disease 9.9 IFNB1 IFNA1
42 japanese encephalitis 9.8 IFNB1 IFNA1
43 lyme disease 9.8 IFNB1 IFNA1
44 mumps 9.8 IFNB1 IFNA1
45 severe acute respiratory syndrome 9.8 IFNB1 IFNA1
46 primary bacterial infectious disease 9.8 IFNB1 IFNA1
47 stomatitis 9.8 IFNB1 IFNA1
48 covid-19 9.8 IFNB1 IFNA1
49 hairy cell leukemia 9.8 IFNB1 IFNA1
50 autoimmune disease 9.8 IFNB1 IFNA1

Graphical network of the top 20 diseases related to Oral Erosive Lichen:



Diseases related to Oral Erosive Lichen

Symptoms & Phenotypes for Oral Erosive Lichen

Human phenotypes related to Oral Erosive Lichen:

58 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0000958
2 cheilitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100825
3 erythema 58 31 hallmark (90%) Very frequent (99-80%) HP:0010783
4 abnormal blistering of the skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0008066
5 lichenification 58 31 hallmark (90%) Very frequent (99-80%) HP:0100725
6 oral ulcer 58 31 hallmark (90%) Very frequent (99-80%) HP:0000155

Drugs & Therapeutics for Oral Erosive Lichen

Drugs for Oral Erosive Lichen (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
2 Analgesics, Non-Narcotic Phase 2
3 Antirheumatic Agents Phase 2
4 Immunosuppressive Agents Phase 2
5 Analgesics Phase 2
6 Immunologic Factors Phase 2
7 Dermatologic Agents Phase 2
8 Anti-Inflammatory Agents Phase 2
9 Calcineurin Inhibitors Phase 2
10 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Study of the Treatment of Oral Erosive Lichen Planus With 1% Pimecrolimus Cream: a Double Blind Randomized Prospective Trial With Measurement of Pimecrolimus Levels in the Blood Terminated NCT00321750 Phase 2 1% pimecrolimus cream

Search NIH Clinical Center for Oral Erosive Lichen

Genetic Tests for Oral Erosive Lichen

Anatomical Context for Oral Erosive Lichen

Publications for Oral Erosive Lichen

Articles related to Oral Erosive Lichen:

(show all 50)
# Title Authors PMID Year
1
Topical rapamycin versus betamethasone dipropionate ointment for treating oral erosive lichen planus: a randomized, double-blind, controlled study. 61
32128907 2020
2
Chronic ulcerative stomatitis: Case series of an under-recognized entity. 61
30159907 2018
3
Evaluation of Serum Desmoglein 1 and Desmoglein 3 in Oral Erosive Lichen Planus before and after Topical Application of Tacrolimus. 61
30498175 2018
4
Evaluation of photodynamic therapy in treatment of oral erosive lichen planus in comparison with topically applied corticosteroids. 61
28450262 2017
5
Antimalarial Drugs for the Treatment of Oral Erosive Lichen Planus. 61
26445088 2016
6
Kinetics of oral colonization by Candida spp. during topical corticotherapy for oral lichen planus. 61
25320748 2014
7
Clinical diagnosis of oral erosive lichen planus by direct oral microscopy. 61
25254007 2014
8
Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. 61
23451852 2014
9
Role of humoral mechanisms in etiology of lichen planus. 61
25754509 2014
10
Oral erosive lichen planus associated with thymoma treated with etretinate. 61
23373893 2013
11
Pimecrolimus 1% cream for oral erosive lichen planus: a 6-week randomized, double-blind, vehicle-controlled study with a 6-week open-label extension to assess efficacy and safety. 61
21175873 2011
12
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). 61
21282092 2011
13
[Oral erosive lichen planus associated with Good syndrome]. 61
20494493 2010
14
Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases. 61
18997452 2009
15
Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa. 61
18853074 2008
16
Oral erosive lichen planus and Good's syndrome: just a coincidence or a direct link between the two diseases? 61
18363920 2008
17
[Clinical and microbiological study of compound of light yellow Sophora root collutory on treatment of oral lichen planus]. 61
18470410 2008
18
Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. 61
17438179 2007
19
Oral erosive lichen planus regression after thymoma resection. 61
17307497 2007
20
A single-center, open-label, prospective pilot study of subcutaneous efalizumab for oral erosive lichen planus. 61
17373193 2007
21
Successful treatment of oral erosive lichen planus with mycophenolate mofetil. 61
17243970 2007
22
Topic tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids: a case report. 61
17072247 2006
23
Psychological health in patients with genital and oral erosive lichen planus. 61
16836492 2006
24
Oral erosive lichen planus treated with efalizumab. 61
16785369 2006
25
The effectiveness of 1% pimecrolimus cream in the treatment of oral erosive lichen planus. 61
15857105 2005
26
Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C. 61
15647837 2005
27
Implant retained overdentures for two patients with severe lichen planus: a clinical report. 61
12589278 2003
28
Erythematosus actinic lichen planus: a new clinical form associated with oral erosive lichen planus and chronic active hepatitis B. 61
12410730 2002
29
Oral erosive lichen planus associated with thymoma. 61
11903672 2001
30
The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. 61
11722711 2001
31
Effective treatment of oral erosive lichen planus with thalidomide. 61
11115153 2000
32
[Prevalence of hepatitis C virus in oral erosive lichen]. 61
9835954 1998
33
Lichen planus associated with hepatitis C. 61
9515215 1998
34
Oral erosive lichen planus with epidermolytic hyperkeratosis during interferon alfa-2b therapy for chronic hepatitis C virus infection. 61
9204077 1997
35
[Photochemotherapy in the treatment of oral erosive lichen planus. Letter]. 61
9235044 1997
36
Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. 61
7552878 1995
37
Appearance of oral erosive lichen planus during interferon alfa-2a therapy for chronic active hepatitis C. 61
7650248 1995
38
Hepatitis C virus infection and oral erosive lichen planus. 61
7798440 1994
39
Serologic and molecular analysis of the HLA system in Israeli Jewish patients with oral erosive lichen planus. 61
8085257 1994
40
Oral lichen planus and hepatitis C virus (HCV) infection: is there a relationship? A report of 10 cases. 61
8021844 1994
41
[A case of a carcinoma arising in lichen planus in a subject with diabetes mellitus and arterial hypertension (Grinspan's syndrome)]. 61
1491659 1992
42
[Cyclosporin in a bioadhesive formulation in the therapy of oral erosive lichen planus. A clinico-experimental evaluation]. 61
1491655 1992
43
[Oral erosive lichen planus: think of chronic liver disease]. 61
2386103 1990
44
[Treatment of oral erosive lichen planus with griseofulvin]. 61
3477604 1987
45
Treatment of localized oral erosive lichen planus lesions with free soft tissue grafts. 61
3507707 1987
46
Treatment of oral erosive lichen planus with systemic isotretinoin. 61
3464912 1986
47
Oral erosive lichen planus and chronic liver disease. 61
3950105 1986
48
Oral erosive lichen planus and chronic active hepatitis. 61
3989029 1985
49
Periodontal and prosthetic treatment in patients with oral lichen planus. 61
3882767 1985
50
Griseofulvin in the treatment of three cases of oral erosive lichen planus. 61
6575336 1983

Variations for Oral Erosive Lichen

Expression for Oral Erosive Lichen

Search GEO for disease gene expression data for Oral Erosive Lichen.

Pathways for Oral Erosive Lichen

Pathways related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 IFNB1 IFNA1
2 12.23 IFNB1 IFNA1
3
Show member pathways
12.16 IFNB1 IFNA1
4
Show member pathways
12 IFNB1 IFNA1
5
Show member pathways
11.98 IFNB1 IFNA1
6
Show member pathways
11.95 IFNB1 IFNA1
7
Show member pathways
11.91 IFNB1 IFNA1
8
Show member pathways
11.8 IFNB1 IFNA1
9
Show member pathways
11.72 IFNB1 IFNA1
10 11.63 IFNB1 IFNA1
11 11.58 IFNB1 IFNA1
12
Show member pathways
11.49 IFNB1 IFNA1
13 11.35 IFNB1 IFNA1
14 10.91 IFNB1 IFNA1
15 10.3 IFNB1 IFNA1

GO Terms for Oral Erosive Lichen

Biological processes related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.52 IFNA1 IFNB1
2 cytokine-mediated signaling pathway GO:0019221 9.51 IFNA1 IFNB1
3 defense response to virus GO:0051607 9.49 IFNA1 IFNB1
4 blood coagulation GO:0007596 9.48 IFNA1 IFNB1
5 defense response GO:0006952 9.46 IFNA1 IFNB1
6 B cell differentiation GO:0030183 9.43 IFNA1 IFNB1
7 type I interferon signaling pathway GO:0060337 9.4 IFNA1 IFNB1
8 humoral immune response GO:0006959 9.37 IFNA1 IFNB1
9 B cell proliferation GO:0042100 9.32 IFNA1 IFNB1
10 response to exogenous dsRNA GO:0043330 9.26 IFNA1 IFNB1
11 T cell activation involved in immune response GO:0002286 9.16 IFNB1 IFNA1
12 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 8.96 IFNB1 IFNA1
13 natural killer cell activation involved in immune response GO:0002323 8.62 IFNB1 IFNA1

Molecular functions related to Oral Erosive Lichen according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.16 IFNB1 IFNA1
2 cytokine receptor binding GO:0005126 8.96 IFNB1 IFNA1
3 type I interferon receptor binding GO:0005132 8.62 IFNB1 IFNA1

Sources for Oral Erosive Lichen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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