MCID: ORL019
MIFTS: 36

Oral Hairy Leukoplakia

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Hairy Leukoplakia

MalaCards integrated aliases for Oral Hairy Leukoplakia:

Name: Oral Hairy Leukoplakia 12 55 15
Leukoplakia, Hairy 44 73
Hairy Leukoplakia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060315
ICD10 33 K13.3
MeSH 44 D017733
NCIt 50 C3722
UMLS 73 C0206186

Summaries for Oral Hairy Leukoplakia

Disease Ontology : 12 A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus.

MalaCards based summary : Oral Hairy Leukoplakia, also known as leukoplakia, hairy, is related to leukoplakia and oral candidiasis. An important gene associated with Oral Hairy Leukoplakia is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Hematopoietic cell lineage. The drugs Dapsone and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include tongue and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hairy leukoplakia (also known as oral hairy leukoplakia, OHL, or HIV-associated hairy leukoplakia), is a... more...

Related Diseases for Oral Hairy Leukoplakia

Diseases related to Oral Hairy Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 leukoplakia 10.8
2 oral candidiasis 10.3
3 candidiasis 10.3
4 leukemia 10.1
5 lichen planus 10.1
6 lymphoma, hodgkin, classic 9.9
7 myeloma, multiple 9.9
8 leukemia, acute myeloid 9.9
9 lymphoma, non-hodgkin, familial 9.9
10 autoimmune lymphoproliferative syndrome, type v 9.9
11 acute lymphocytic leukemia 9.9
12 lymphoma 9.9
13 sarcoma 9.9
14 keratosis 9.9
15 squamous cell carcinoma 9.9
16 secondary syphilis 9.9
17 syphilis 9.9
18 myeloid leukemia 9.9
19 stomatitis 9.9
20 oral lichen planus 9.9

Graphical network of the top 20 diseases related to Oral Hairy Leukoplakia:



Diseases related to Oral Hairy Leukoplakia

Symptoms & Phenotypes for Oral Hairy Leukoplakia

GenomeRNAi Phenotypes related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.55 PRDM1 RHOG
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 PRDM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.55 PRDM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.55 RHOG
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.55 PRDM1 RHOG
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.55 PRDM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.55 RHOG
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.55 PRDM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 PRDM1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.55 RHOG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 RHOG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.55 RHOG
13 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.55 PRDM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.55 RHOG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.55 PRDM1

MGI Mouse Phenotypes related to Oral Hairy Leukoplakia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CR2 ITGA2 KRT14 PRDM1 PSMB9 RHOG
2 immune system MP:0005387 9.02 CR2 KRT14 PRDM1 PSMB9 RHOG

Drugs & Therapeutics for Oral Hairy Leukoplakia

Drugs for Oral Hairy Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Not Applicable 80-08-0 2955
2
Acyclovir Approved Not Applicable 59277-89-3 2022
3
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5 Folic Acid Antagonists Not Applicable
6 Anti-Bacterial Agents Not Applicable
7 Vitamin B Complex Not Applicable
8 Anti-Infective Agents Not Applicable
9 Antiparasitic Agents Not Applicable
10 Antiprotozoal Agents Not Applicable
11 Antimalarials Not Applicable
12 Antiviral Agents Not Applicable
13 Folate Nutraceutical Not Applicable
14 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV) Completed NCT00002026 Not Applicable Acyclovir
2 Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC) Completed NCT00002043 Not Applicable Dapsone

Search NIH Clinical Center for Oral Hairy Leukoplakia

Cochrane evidence based reviews: leukoplakia, hairy

Genetic Tests for Oral Hairy Leukoplakia

Anatomical Context for Oral Hairy Leukoplakia

MalaCards organs/tissues related to Oral Hairy Leukoplakia:

41
Tongue, Myeloid

Publications for Oral Hairy Leukoplakia

Articles related to Oral Hairy Leukoplakia:

(show top 50) (show all 71)
# Title Authors Year
1
Considerations in the diagnosis of oral hairy leukoplakia-an institutional experience. ( 29325854 )
2018
2
Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case. ( 28385698 )
2017
3
Diagnosis of Oral Hairy Leukoplakia: The Importance of EBV In Situ Hybridization. ( 28798771 )
2017
4
Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. ( 27047546 )
2016
5
Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients. ( 27901200 )
2016
6
Twenty-first-century oral hairy leukoplakia--a non-HIV-associated entity. ( 25600979 )
2015
7
Oral hairy leukoplakia diagnosis by Epstein-Barr virus inA situ hybridization in liquid-based cytology. ( 23445399 )
2014
8
Oral hairy leukoplakia in patients without HIV: presentation of 2A new cases. ( 25096885 )
2014
9
Critical review of topical management of oral hairy leukoplakia. ( 25032199 )
2014
10
Oral hairy leukoplakia in healthy, immunocompetent individuals. ( 24988836 )
2014
11
Oral hairy leukoplakia. ( 24428034 )
2013
12
Oral hairy leukoplakia in an HIV-negative patient. ( 23780596 )
2013
13
The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma. ( 22924124 )
2012
14
Quiz questions. Idiopathic leukoplakia, tobacoco-induced leukoplakia, frictional keratosis, plaque lichen planus, candidal leukoplakia (chronic hyperplastic leukoplakia), squamous cell carcinoma, lichenoid reaction to drug or amalgam, or oral hairy leukoplakia. ( 21922989 )
2011
15
Oral hairy leukoplakia: a clinical indicator of immunosuppression. ( 21398239 )
2011
16
Oral hairy leukoplakia. ( 22128498 )
2011
17
Iatrogenic oral hairy leukoplakia: report of two cases. ( 21121942 )
2011
18
Oral hairy leukoplakia in a patient on long-term anticonvulsant treatment with lamotrigine. ( 21429773 )
2011
19
Oral hairy leukoplakia: An exfoliative cytology study. ( 22114370 )
2010
20
Human papillomavirus and Epstein Barr virus in oral hairy leukoplakia among HIV positive Venezuelan patients. ( 21053684 )
2010
21
Oral hairy leukoplakia which occurred as a presenting sign of acute myeloid leukemia in a child. ( 20548888 )
2010
22
Epstein Barr Virus detection and latent membrane protein 1 in oral hairy leukoplakia in HIV+ Venezuelan patients. ( 20038918 )
2010
23
A new topical treatment protocol for oral hairy leukoplakia. ( 20813564 )
2010
24
Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. ( 19033322 )
2010
25
Targeted therapy of oral hairy leukoplakia with gentian violet. ( 18342722 )
2008
26
Oral hairy leukoplakia arising in an oral lichen planus lesion in an otherwise immune-competent patient. ( 17892032 )
2007
27
A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. ( 17178496 )
2007
28
Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. ( 18240892 )
2007
29
Prevalence of oral hairy leukoplakia in 120 pediatric patients infected with HIV-1. ( 16878201 )
2006
30
Oral candidosis and oral hairy leukoplakia as predictors of HAART failure in Brazilian HIV-infected patients. ( 16792726 )
2006
31
Oral hairy leukoplakia--a case report. ( 16875019 )
2006
32
Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. ( 16762011 )
2006
33
Efficacy of famciclovir in the treatment of oral hairy leukoplakia. ( 16433817 )
2006
34
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. ( 15599347 )
2005
35
Lack of evidence for local immune activity in oral hairy leukoplakia and oral wart lesions. ( 15836516 )
2005
36
Epstein-Barr virus in oral hairy leukoplakia scrapes: identification by PCR. ( 16491263 )
2005
37
Risk indicators for oral candidiasis and oral hairy leukoplakia in HIV-infected adults. ( 15642045 )
2005
38
Effect of Epstein-Barr virus replication on Langerhans cells in pathogenesis of oral hairy leukoplakia. ( 15116302 )
2004
39
Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia. ( 15216478 )
2004
40
Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia. ( 15216477 )
2004
41
Intracellular localization of the Epstein-Barr virus BFRF1 gene product in lymphoid cell lines and oral hairy leukoplakia lesions. ( 14635017 )
2004
42
Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovir. ( 12964120 )
2003
43
Secondary syphilis simulating oral hairy leukoplakia. ( 14512934 )
2003
44
Infection fighters. High-dose Valtrex for oral hairy leukoplakia. ( 17216869 )
2003
45
Oral hairy leukoplakia as an early indicator of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder. ( 12149746 )
2002
46
A retrospective analysis of oral hairy leukoplakia in South Australia. ( 11491226 )
2001
47
Predictors and prognostic value of oral hairy leukoplakia and oral candidiasis in South African HIV-infected patients. ( 11887444 )
2001
48
Morsicatio linguarum versus oral hairy leukoplakia. ( 11096212 )
2000
49
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. ( 10822365 )
2000
50
Human immunodeficiency virus-positive individuals with oral hairy leukoplakia are able to mount cytotoxic T lymphocyte responses to Epstein-Barr virus. ( 10673787 )
2000

Variations for Oral Hairy Leukoplakia

Expression for Oral Hairy Leukoplakia

Search GEO for disease gene expression data for Oral Hairy Leukoplakia.

Pathways for Oral Hairy Leukoplakia

Pathways related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 ITGA2 KRT14 PSMB9 RHOG
2 11.14 CR2 ITGA2
3 10.89 ITGA2 RHOG
4 10.35 CR2 PRDM1

GO Terms for Oral Hairy Leukoplakia

Biological processes related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.33 CR2 PRDM1 PSMB9
2 viral entry into host cell GO:0046718 8.96 CR2 ITGA2
3 viral process GO:0016032 8.8 CR2 ITGA2 PSMB9

Molecular functions related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR2 ITGA2

Sources for Oral Hairy Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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