MCID: ORL019
MIFTS: 38

Oral Hairy Leukoplakia

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Hairy Leukoplakia

MalaCards integrated aliases for Oral Hairy Leukoplakia:

Name: Oral Hairy Leukoplakia 12 56 15
Leukoplakia, Hairy 45 17 74
Hairy Leukoplakia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060315
MeSH 45 D017733
NCIt 51 C3722
SNOMED-CT 69 58918007
ICD10 34 K13.3
UMLS 74 C0206186

Summaries for Oral Hairy Leukoplakia

Disease Ontology : 12 A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus.

MalaCards based summary : Oral Hairy Leukoplakia, also known as leukoplakia, hairy, is related to leukoplakia and oral candidiasis. An important gene associated with Oral Hairy Leukoplakia is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Hematopoietic cell lineage. The drugs Acyclovir and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include tongue, myeloid and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Hairy leukoplakia is a white patch on the side of the tongue with a corrugated or hairy appearance. It... more...

Related Diseases for Oral Hairy Leukoplakia

Diseases related to Oral Hairy Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 leukoplakia 11.2
2 oral candidiasis 10.5
3 candidiasis 10.5
4 human immunodeficiency virus infectious disease 10.3
5 acquired immunodeficiency syndrome 10.3
6 leukemia 10.2
7 lichen planus 10.2
8 behcet syndrome 10.1
9 kaposi sarcoma 10.1
10 systemic lupus erythematosus 10.1
11 lymphoma, hodgkin, classic 10.1
12 myeloma, multiple 10.1
13 leukemia, acute myeloid 10.1
14 lymphoma, non-hodgkin, familial 10.1
15 acute lymphocytic leukemia 10.1
16 diabetes mellitus 10.1
17 post-transplant lymphoproliferative disease 10.1
18 ulcerative colitis 10.1
19 lymphoma 10.1
20 colitis 10.1
21 lymphoproliferative syndrome 10.1
22 lymphocytic leukemia 10.1
23 sarcoma 10.1
24 keratosis 10.1
25 squamous cell carcinoma 10.1
26 secondary syphilis 10.1
27 syphilis 10.1
28 myeloid leukemia 10.1
29 lupus erythematosus 10.1
30 stomatitis 10.1
31 oral lichen planus 10.1
32 white sponge nevus 1 10.0
33 myelodysplastic syndrome 10.0
34 hairy tongue 10.0
35 dermatitis 10.0
36 black hairy tongue 10.0

Graphical network of the top 20 diseases related to Oral Hairy Leukoplakia:



Diseases related to Oral Hairy Leukoplakia

Symptoms & Phenotypes for Oral Hairy Leukoplakia

GenomeRNAi Phenotypes related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.55 PRDM1 RHOG
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 PRDM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.55 PRDM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.55 RHOG
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.55 PRDM1 RHOG
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.55 PRDM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.55 RHOG
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.55 PRDM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 PRDM1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.55 RHOG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 RHOG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.55 RHOG
13 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.55 PRDM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.55 RHOG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.55 PRDM1

MGI Mouse Phenotypes related to Oral Hairy Leukoplakia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CR2 ITGA2 KRT14 PRDM1 PSMB9 RHOG
2 immune system MP:0005387 9.02 CR2 KRT14 PRDM1 PSMB9 RHOG

Drugs & Therapeutics for Oral Hairy Leukoplakia

Drugs for Oral Hairy Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Not Applicable 59277-89-3 2022
2
Dapsone Approved, Investigational Not Applicable 80-08-0 2955
3
leucovorin Approved Not Applicable 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5 Anti-Infective Agents Not Applicable
6 Antiviral Agents Not Applicable
7 Anti-Bacterial Agents Not Applicable
8 Antimalarials Not Applicable
9 Vitamin B Complex Not Applicable
10 Vitamin B9 Not Applicable
11 Antiparasitic Agents Not Applicable
12 Folic Acid Antagonists Not Applicable
13 Folate Not Applicable
14 Antiprotozoal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV) Completed NCT00002026 Not Applicable Acyclovir
2 Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC) Completed NCT00002043 Not Applicable Dapsone

Search NIH Clinical Center for Oral Hairy Leukoplakia

Cochrane evidence based reviews: leukoplakia, hairy

Genetic Tests for Oral Hairy Leukoplakia

Anatomical Context for Oral Hairy Leukoplakia

MalaCards organs/tissues related to Oral Hairy Leukoplakia:

42
Tongue, Myeloid, Heart, T Cells

Publications for Oral Hairy Leukoplakia

Articles related to Oral Hairy Leukoplakia:

(show top 50) (show all 171)
# Title Authors Year
1
Oral hairy leukoplakia in healthy immunocompetent patients: a small case series. ( 30079439 )
2018
2
Considerations in the diagnosis of oral hairy leukoplakia-an institutional experience. ( 29325854 )
2018
3
Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case. ( 28385698 )
2017
4
Diagnosis of Oral Hairy Leukoplakia: The Importance of EBV In Situ Hybridization. ( 28798771 )
2017
5
Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients. ( 27901200 )
2016
6
Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. ( 27047546 )
2016
7
Twenty-first-century oral hairy leukoplakia--a non-HIV-associated entity. ( 25600979 )
2015
8
Oral hairy leukoplakia diagnosis by Epstein-Barr virus in situ hybridization in liquid-based cytology. ( 23445399 )
2014
9
Oral hairy leukoplakia in healthy, immunocompetent individuals. ( 24988836 )
2014
10
Critical review of topical management of oral hairy leukoplakia. ( 25032199 )
2014
11
Oral hairy leukoplakia in patients without HIV: presentation of 2 new cases. ( 25096885 )
2014
12
Oral hairy leukoplakia in an HIV-negative patient. ( 23780596 )
2013
13
Oral hairy leukoplakia. ( 24428034 )
2013
14
The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma. ( 22924124 )
2012
15
Quiz questions. Idiopathic leukoplakia, tobacoco-induced leukoplakia, frictional keratosis, plaque lichen planus, candidal leukoplakia (chronic hyperplastic leukoplakia), squamous cell carcinoma, lichenoid reaction to drug or amalgam, or oral hairy leukoplakia. ( 21922989 )
2011
16
Iatrogenic oral hairy leukoplakia: report of two cases. ( 21121942 )
2011
17
Oral hairy leukoplakia: a clinical indicator of immunosuppression. ( 21398239 )
2011
18
Oral hairy leukoplakia in a patient on long-term anticonvulsant treatment with lamotrigine. ( 21429773 )
2011
19
Oral hairy leukoplakia. ( 22128498 )
2011
20
Oral hairy leukoplakia which occurred as a presenting sign of acute myeloid leukemia in a child. ( 20548888 )
2010
21
A new topical treatment protocol for oral hairy leukoplakia. ( 20813564 )
2010
22
Human papillomavirus and Epstein Barr virus in oral hairy leukoplakia among HIV positive Venezuelan patients. ( 21053684 )
2010
23
Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. ( 19033322 )
2010
24
Epstein Barr Virus detection and latent membrane protein 1 in oral hairy leukoplakia in HIV+ Venezuelan patients. ( 20038918 )
2010
25
Oral hairy leukoplakia: An exfoliative cytology study. ( 22114370 )
2010
26
Targeted therapy of oral hairy leukoplakia with gentian violet. ( 18342722 )
2008
27
Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. ( 18240892 )
2007
28
A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. ( 17178496 )
2007
29
Prevalence of oral hairy leukoplakia and epithelial infection by Epstein-Barr virus in pregnant women and diabetes mellitus patients--cytopathologic and molecular study. ( 17426879 )
2007
30
Oral hairy leukoplakia arising in an oral lichen planus lesion in an otherwise immune-competent patient. ( 17892032 )
2007
31
Oral candidosis and oral hairy leukoplakia as predictors of HAART failure in Brazilian HIV-infected patients. ( 16792726 )
2006
32
Oral hairy leukoplakia--a case report. ( 16875019 )
2006
33
Prevalence of oral hairy leukoplakia in 120 pediatric patients infected with HIV-1. ( 16878201 )
2006
34
Efficacy of famciclovir in the treatment of oral hairy leukoplakia. ( 16433817 )
2006
35
Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. ( 16762011 )
2006
36
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. ( 15599347 )
2005
37
Risk indicators for oral candidiasis and oral hairy leukoplakia in HIV-infected adults. ( 15642045 )
2005
38
Lack of evidence for local immune activity in oral hairy leukoplakia and oral wart lesions. ( 15836516 )
2005
39
Epstein-Barr virus in oral hairy leukoplakia scrapes: identification by PCR. ( 16491263 )
2005
40
Intracellular localization of the Epstein-Barr virus BFRF1 gene product in lymphoid cell lines and oral hairy leukoplakia lesions. ( 14635017 )
2004
41
Effect of Epstein-Barr virus replication on Langerhans cells in pathogenesis of oral hairy leukoplakia. ( 15116302 )
2004
42
Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia. ( 15216477 )
2004
43
Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia. ( 15216478 )
2004
44
Infection fighters. High-dose Valtrex for oral hairy leukoplakia. ( 17216869 )
2003
45
Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovir. ( 12964120 )
2003
46
Secondary syphilis simulating oral hairy leukoplakia. ( 14512934 )
2003
47
Oral hairy leukoplakia as an early indicator of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder. ( 12149746 )
2002
48
Predictors and prognostic value of oral hairy leukoplakia and oral candidiasis in South African HIV-infected patients. ( 11887444 )
2001
49
A retrospective analysis of oral hairy leukoplakia in South Australia. ( 11491226 )
2001
50
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. ( 10822365 )
2000

Variations for Oral Hairy Leukoplakia

Expression for Oral Hairy Leukoplakia

Search GEO for disease gene expression data for Oral Hairy Leukoplakia.

Pathways for Oral Hairy Leukoplakia

Pathways related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 ITGA2 KRT14 PSMB9 RHOG
2 11.14 CR2 ITGA2
3 10.89 ITGA2 RHOG
4 10.35 CR2 PRDM1

GO Terms for Oral Hairy Leukoplakia

Cellular components related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal part of cell GO:0045178 8.62 ITGA2 KRT14

Biological processes related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.33 CR2 PRDM1 PSMB9
2 viral entry into host cell GO:0046718 8.96 CR2 ITGA2
3 viral process GO:0016032 8.8 CR2 ITGA2 PSMB9

Molecular functions related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR2 ITGA2

Sources for Oral Hairy Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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