MCID: ORL019
MIFTS: 39

Oral Hairy Leukoplakia

Categories: Gastrointestinal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Oral Hairy Leukoplakia

MalaCards integrated aliases for Oral Hairy Leukoplakia:

Name: Oral Hairy Leukoplakia 12 54 15
Leukoplakia, Hairy 44 17 70
Hairy Leukoplakia 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:0060315
MeSH 44 D017733
NCIt 50 C3722
SNOMED-CT 67 58918007
ICD10 32 K13.3
UMLS 70 C0206186

Summaries for Oral Hairy Leukoplakia

Disease Ontology : 12 A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus.

MalaCards based summary : Oral Hairy Leukoplakia, also known as leukoplakia, hairy, is related to secondary syphilis and acquired immunodeficiency syndrome. An important gene associated with Oral Hairy Leukoplakia is KRT14 (Keratin 14), and among its related pathways/superpathways are Yersinia infection and Amoebiasis. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and bone, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 73 Hairy leukoplakia is a white patch on the side of the tongue with a corrugated or hairy appearance. It... more...

Related Diseases for Oral Hairy Leukoplakia

Diseases related to Oral Hairy Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 secondary syphilis 30.6 CD8A CD4
2 acquired immunodeficiency syndrome 30.4 ITIH4 IL10 CR2 CD4
3 chickenpox 30.2 IL10 CD8A CD4
4 pfeiffer syndrome 30.1 PSMB9 CR2 CD8A CD4
5 herpes zoster 30.0 IL10 CD8A CD4
6 myeloma, multiple 29.9 PRDM1 IL10 CD8A CD4
7 dermatitis 29.8 PSMB9 IL10 CD8A CD4
8 human immunodeficiency virus type 1 29.5 ITIH4 IL10 CR2 CD4
9 systemic lupus erythematosus 29.3 PSMB9 PRDM1 ITGA2 IL10 CR2 CD4
10 immune deficiency disease 29.3 ITIH4 IL10 CR2 CD8A CD4
11 disease by infectious agent 29.2 ITIH4 IL10 CD8A CD4 CD1A
12 leukoplakia 11.2
13 candidiasis 10.7
14 oral candidiasis 10.6
15 papilloma 10.5
16 squamous cell papilloma 10.4
17 keratosis 10.4
18 lichen planus 10.4
19 cork-handlers' disease 10.4 CD8A CD4
20 necrotic uveal melanoma 10.4 CD8A CD4
21 lobomycosis 10.3 CR2 CD4
22 early yaws 10.3 CD8A CD4
23 ventilation pneumonitis 10.3 CD8A CD4
24 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
25 latent syphilis 10.3 CD8A CD4
26 type 1 diabetes mellitus 23 10.3 CD8A CD4
27 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
28 subacute lymphocytic thyroiditis 10.3 CR2 CD4
29 parapsoriasis 10.3 CD8A CD4
30 gastroduodenitis 10.3 CD8A CD4
31 duodenitis 10.3 CD8A CD4
32 primary syphilis 10.3 CD8A CD4
33 norwegian scabies 10.3 CD8A CD4
34 dermatomycosis 10.3 CR2 CD4
35 bird fancier's lung 10.3 CD8A CD4
36 skin sarcoidosis 10.3 CD8A CD4
37 variola major 10.3 CD8A CD4
38 follicular mucinosis 10.3 CD8A CD4
39 reticulum cell sarcoma 10.3 CR2 CD4
40 cerebral lymphoma 10.3 CD8A CD4
41 oral tuberculosis 10.3 CD8A CD4
42 cerebritis 10.3 CD8A CD4
43 invasive malignant thymoma 10.3 CD8A CD4
44 west nile encephalitis 10.3 CD8A CD4
45 exanthema subitum 10.3 CD8A CD4
46 immunodeficiency 36 10.3 CD8A CD4
47 viral exanthem 10.3 CD8A CD4
48 acute interstitial pneumonia 10.3 CD8A CD4
49 glanders 10.3 CD8A CD4
50 superficial basal cell carcinoma 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Oral Hairy Leukoplakia:



Diseases related to Oral Hairy Leukoplakia

Symptoms & Phenotypes for Oral Hairy Leukoplakia

MGI Mouse Phenotypes related to Oral Hairy Leukoplakia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 ARL2BP CD4 CD8A IL10 ITGA2 ITIH4
2 endocrine/exocrine gland MP:0005379 9.56 CD4 CD8A IL10 ITGA2 ITIH4 KRT14
3 hematopoietic system MP:0005397 9.28 CD4 CD8A CR2 IL10 ITGA2 KRT14

Drugs & Therapeutics for Oral Hairy Leukoplakia

Drugs for Oral Hairy Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved 59277-89-3 2022
2 Anti-Infective Agents
3 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV) Completed NCT00002026 Acyclovir

Search NIH Clinical Center for Oral Hairy Leukoplakia

Cochrane evidence based reviews: leukoplakia, hairy

Genetic Tests for Oral Hairy Leukoplakia

Anatomical Context for Oral Hairy Leukoplakia

MalaCards organs/tissues related to Oral Hairy Leukoplakia:

40
Tongue, Skin, Bone, Myeloid, Thymus, Liver, Lung

Publications for Oral Hairy Leukoplakia

Articles related to Oral Hairy Leukoplakia:

(show top 50) (show all 444)
# Title Authors PMID Year
1
Expression of keratin 14 and 19 mRNA and protein in normal oral epithelia, hairy leukoplakia, tongue biting and white sponge nevus. 61 54
7686226 1993
2
Oral Hairy Leukoplakia in Immunocompetent Patients Revisited with Literature Review. 61
33428065 2021
3
Oral Hairy Leukoplakia Related to Orodispersible Budesonide Use. 61
33324718 2020
4
Diagnosis of latent tuberculosis infection is associated with reduced HIV viral load and lower risk for opportunistic infections in people living with HIV. 61
33284802 2020
5
Oral hairy leukoplakia associated with the use of adalimumab. 61
33465198 2020
6
A real-world, cross sectional study of oral lesions and their association with CD4 cell counts and HIV viral load in Yunnan, China. 61
33019418 2020
7
Detection of Epstein-Barr virus DNA in saliva of HIV-1-infected individuals with oral hairy leukoplakia. 61
32862526 2020
8
Treatment options for oral hairy leukoplakia: A case report. 61
33462916 2020
9
Oral hairy leukoplakia in a child using a corticosteroid nasal spray. 61
32372427 2020
10
Oral health status and treatment needs among HIV/AIDS patients attending antiretroviral therapy center in Western India: A cross-sectional study. 61
33102357 2020
11
Racial differences in dermatologic conditions associated with HIV: A cross-sectional study of 4679 patients in an urban tertiary care center. 61
31499147 2020
12
Oral Manifestations in HIV-TB Co- infected Patients and Their Correlation with CD4 Count in Telangana State, India. 61
32181218 2020
13
Hairy Tongue: Differential Diagnosis by Use of Widefield Optical Fluorescence. 61
30970064 2019
14
Oral hairy leukoplakia in healthy immunocompetent patients: a small case series. 61
30079439 2018
15
Oral Hairy Leukoplakia in Patients With No Evidence of Immunosuppression: A Case Series and Review of the Literature. 61
31199724 2018
16
Considerations in the diagnosis of oral hairy leukoplakia-an institutional experience. 61
29325854 2018
17
Encyclopedia of EBV-Encoded Lytic Genes: An Update. 61
29896677 2018
18
Prevalence of HIV-related oral manifestations and their association with HAART and CD4+ T cell count: a review. 61
29460518 2018
19
Impact of highly active antiretroviral therapy on the prevalence of oral lesions in HIV-positive patients: a systematic review and meta-analysis. 61
28684301 2017
20
Oral lesions as an important marker for HIV progression. 61
29469724 2017
21
Epstein-Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity. 61
28725300 2017
22
A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells. 61
28514666 2017
23
Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells. 61
28179525 2017
24
Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case. 61
28385698 2017
25
Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana. 61
28280707 2017
26
Diagnosis of Oral Hairy Leukoplakia: The Importance of EBV In Situ Hybridization. 61
28798771 2017
27
Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients. 61
27901200 2016
28
Diseases of the tongue. 61
27343960 2016
29
Hairy leukoplakia; lessons learned: 30-plus years. 61
27109280 2016
30
Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. 61
27047546 2016
31
Current strategies for prevention of oral manifestations of human immunodeficiency virus. 61
26679357 2016
32
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. 61
26431332 2015
33
[Oral hairy leukoplakia induced by topical steroids]. 61
26362131 2015
34
Operational research on the correlation between skin diseases and HIV infection in Tigray region, Ethiopia. 61
26394603 2015
35
Oral manifestations of HIV/AIDS in Asia: Systematic review and future research guidelines. 61
26330942 2015
36
Twenty-first-century oral hairy leukoplakia--a non-HIV-associated entity. 61
25600979 2015
37
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. 61
25410866 2015
38
Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis. 61
26862355 2015
39
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa. 61
25749203 2015
40
Association between oral candidiasis and low CD4+ count among HIV positive patients in Hoima Regional Referral Hospital. 61
25432363 2014
41
Knowledge, attitudes and practices of oral health care workers in Lesotho regarding the management of patients with oral manifestations of HIV/AIDS. 61
26506796 2014
42
Oral hairy leukoplakia in patients without HIV: presentation of 2 new cases. 61
25096885 2014
43
Black hairy tongue syndrome. 61
25152586 2014
44
[Clinical features of oral lesions in patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome in Guangxi autonomous region]. 61
25351216 2014
45
Significance of Epstein-Barr virus (HHV-4) and CMV (HHV-5) infection among subtype-C human immunodeficiency virus-infected individuals. 61
25008818 2014
46
Critical review of topical management of oral hairy leukoplakia. 61
25032199 2014
47
Oral hairy leukoplakia in healthy, immunocompetent individuals. 61
24988836 2014
48
Oral hairy leukoplakia diagnosis by Epstein-Barr virus in situ hybridization in liquid-based cytology. 61
23445399 2014
49
Development of a clinical scoring system for assessment of immunosuppression in patients with tuberculosis and HIV infection without access to CD4 cell testing--results from a cross-sectional study in Ethiopia. 61
24560255 2014
50
Epstein-Barr virus and skin manifestations in childhood. 61
24073903 2013

Variations for Oral Hairy Leukoplakia

Expression for Oral Hairy Leukoplakia

Search GEO for disease gene expression data for Oral Hairy Leukoplakia.

Pathways for Oral Hairy Leukoplakia

GO Terms for Oral Hairy Leukoplakia

Cellular components related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 ITGA2 CD8A CD4 CD1E CD1A
2 basal part of cell GO:0045178 8.96 KRT14 ITGA2

Biological processes related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.55 PRDM1 CD8A CD4 CD1E CD1A
2 immune response GO:0006955 9.43 IL10 CR2 CD8A CD4 CD1E CD1A
3 positive regulation of T cell mediated cytotoxicity GO:0001916 9.37 CD1E CD1A
4 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.32 CD1E CD1A
5 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.26 CD1E CD1A
6 immune system process GO:0002376 9.17 PSMB9 PRDM1 CR2 CD8A CD4 CD1E

Molecular functions related to Oral Hairy Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.33 ITGA2 CR2 CD4
2 lipopeptide binding GO:0071723 9.26 CD1E CD1A
3 exogenous lipid antigen binding GO:0030884 8.96 CD1E CD1A
4 endogenous lipid antigen binding GO:0030883 8.62 CD1E CD1A

Sources for Oral Hairy Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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