MCID: ORL013
MIFTS: 51

Oral Lichen Planus

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Oral Lichen Planus

MalaCards integrated aliases for Oral Lichen Planus:

Name: Oral Lichen Planus 53
Oral Lichenoid Lesions 53
Lichen Planus, Oral 73
Lichen Planus Oral 55

Classifications:



External Ids:

UMLS 73 C0206139

Summaries for Oral Lichen Planus

NIH Rare Diseases : 53 Oral lichen planus is a inflammatory condition that affects the inside of the mouth.  Signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. Most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. Severe lichen planus slightly increases the risk for oral cancer. Oral lichen planus may occur alone or in combination with other skin forms of lichen planus.

MalaCards based summary : Oral Lichen Planus, also known as oral lichenoid lesions, is related to vulvovaginitis and lichen planus, and has symptoms including oral manifestations An important gene associated with Oral Lichen Planus is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Triamcinolone and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and t cells, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and cardiovascular system

Related Diseases for Oral Lichen Planus

Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 vulvovaginitis 30.6 CCL5 HSPD1
2 lichen planus 11.3
3 lymphocytic vasculitis 10.8 ICAM1 VCAM1
4 heterophyiasis 10.7 CASP3 ICAM1
5 mooren's ulcer 10.7 ICAM1 VCAM1
6 whiplash 10.7 CCL5 CCR5
7 subendocardial myocardial infarction 10.6 ICAM1 VCAM1
8 hepatitis 10.6
9 hepatitis c 10.6
10 squamous cell carcinoma 10.6
11 cytomegalovirus infection 10.6 CCL5 ICAM1 VCAM1
12 dengue disease 10.5 CCL5 ICAM1 VCAM1
13 leukoplakia 10.5
14 rheumatoid vasculitis 10.5 ICAM1 VCAM1
15 trypanosomiasis 10.5 CCL5 ICAM1 VCAM1
16 hepatitis c virus 10.5
17 immune-complex glomerulonephritis 10.5 CCR5 ICAM1 VCAM1
18 oral squamous cell carcinoma 10.5
19 tendinopathy 10.5 CASP3 MMP1
20 rhinitis 10.5 CCL5 ICAM1 VCAM1
21 crescentic glomerulonephritis 10.5 CCR5 ICAM1 VCAM1
22 internal hemorrhoid 10.5 CASP3 MMP1
23 idiopathic neutropenia 10.4 CASP3 CCL5 IL1A
24 stachybotrys chartarum 10.4 CCL5 IL1A
25 gingivitis 10.4
26 yellow fever 10.4 CCL5 CCR5 IL1A
27 periodontitis, aggressive, 1 10.4 IL1A MMP1
28 arteriosclerosis 10.3 HSPD1 ICAM1 VCAM1
29 periodontitis 10.3
30 oral leukoplakia 10.3
31 chronic venous insufficiency 10.3 ICAM1 MMP1 VCAM1
32 venous insufficiency 10.3 ICAM1 MMP1 VCAM1
33 thyroiditis 10.3
34 stomatitis 10.3
35 synovitis 10.3 ICAM1 MMP1 VCAM1
36 mucositis 10.3
37 chronic eosinophilic pneumonia 10.2 CCL5 CXCR3 ICAM1
38 vernal keratoconjunctivitis 10.2 CCL5 CXCR3 ICAM1
39 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 CCL5 ICAM1 IL1A VCAM1
40 burning mouth syndrome 10.2
41 burns 10.2
42 pemphigus 10.2
43 depression 10.2
44 hypothyroidism 10.2
45 oral cancer 10.2
46 radiculopathy 10.2 CCL5 CXCR3 IL1A
47 orofacial granulomatosis 10.2 CCL5 CCR5 CXCR3
48 sarcoidosis 1 10.2 CCL5 CXCR3 ICAM1
49 lymphadenitis 10.2 CASP3 CXCR3 ICAM1
50 cortical thymoma 10.1 CD58 ICAM1 VCAM1

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to Oral Lichen Planus

Symptoms & Phenotypes for Oral Lichen Planus

UMLS symptoms related to Oral Lichen Planus:


oral manifestations

GenomeRNAi Phenotypes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.8 CD58 HSPD1 IL1A

MGI Mouse Phenotypes related to Oral Lichen Planus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ICAM1 IL1A CASP3 TIMP2 CCR5 TP63
2 hematopoietic system MP:0005397 9.97 ICAM1 BAX IL1A CASP3 TIMP2 CCL5
3 homeostasis/metabolism MP:0005376 9.96 ICAM1 BAX IL1A CASP3 MMP1 TIMP2
4 immune system MP:0005387 9.9 ICAM1 BAX IL1A CASP3 MMP1 TIMP2
5 muscle MP:0005369 9.43 HSPD1 ICAM1 BAX CASP3 CCR5 TP63
6 neoplasm MP:0002006 9.17 ICAM1 BAX IL1A MMP1 CCR5 TP63

Drugs & Therapeutics for Oral Lichen Planus

Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 124-94-7 31307
2
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492
3
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
4
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 22916-47-8 4189
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
7
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
9 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
10
Chitosan Approved, Nutraceutical Phase 4 9012-76-4 71853
11
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
12 Lycopene Approved, Investigational, Nutraceutical Phase 4,Phase 2 502-65-8 446925
13
Lactitol Investigational Phase 4 585-86-4 3871
14 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
15 Analgesics Phase 4,Phase 3,Phase 2
16 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
18 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
19 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Dermatologic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
21 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
22 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
23 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
27 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
28 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
29 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
32 Antirheumatic Agents Phase 4,Phase 3,Phase 2
33 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
35 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
36 Prednisolone acetate Phase 4,Phase 2
37 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
38 Respiratory System Agents Phase 4,Phase 3,Phase 2
39 Methylprednisolone acetate Phase 4,Phase 2
40 Methylprednisolone Hemisuccinate Phase 4,Phase 2
41 Neuroprotective Agents Phase 4
42 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
43 Prednisolone hemisuccinate Phase 4,Phase 2
44 Prednisolone phosphate Phase 4,Phase 2
45 Antifungal Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
46 Radiation-Protective Agents Phase 4,Phase 2
47 Betamethasone benzoate Phase 4,Phase 3,Phase 2
48 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2
49 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2
50 Carotenoids Phase 4,Phase 2

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
6 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
7 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
8 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
9 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
11 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
12 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
13 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
14 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
15 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
16 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
17 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
18 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
19 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
20 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
21 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
22 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
23 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
24 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
25 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
26 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
27 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Not yet recruiting NCT03509675 Phase 2 Non-Steroidal Anti-inflammatory Topical Rinse;Placebos
28 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
29 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
30 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
31 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573 Not Applicable
32 Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study Unknown status NCT02332486 Not Applicable Qingxuan Decoction
33 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable
34 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
35 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Completed NCT03011658 Not Applicable
36 The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2) Completed NCT03257228
37 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607 Not Applicable
38 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690 Not Applicable Nystatin;fluocinolone
39 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
40 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107 Not Applicable efalizumab
41 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899 Not Applicable
42 Treatment Modalities of Oral Lichen Planus Recruiting NCT03237533 Early Phase 1 Dexamethasone
43 Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus Recruiting NCT03415165 Early Phase 1 green tea buccal tablet;Corticosteroids Topical
44 Use of Injectable Platelet Rich Fibrin in Lichen Planus Recruiting NCT03265093 Not Applicable Corticosteroid
45 Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients Active, not recruiting NCT03529604
46 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus Not yet recruiting NCT03052179 Not Applicable
47 Photobiomodulation in Oral Lichen Planus Not yet recruiting NCT03320460 Not Applicable Propionate clobetasol gel 0.05%
48 Tacrolimus Ointment in Oral Lichen Planus Terminated NCT01544842 Not Applicable 0.1 % tacrolimus ointment;0.1 % triamcinolone paste;Orabase paste

Search NIH Clinical Center for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

MalaCards organs/tissues related to Oral Lichen Planus:

41
Tongue, Skin, T Cells, Thyroid, Testes, Endothelial, Monocytes

Publications for Oral Lichen Planus

Articles related to Oral Lichen Planus:

(show top 50) (show all 792)
# Title Authors Year
1
Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial. ( 29909565 )
2018
2
Participation of the Th17 response in the pathogenesis of oral lichen planus. ( 29314294 )
2018
3
Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus. ( 29297958 )
2018
4
MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). ( 29813046 )
2018
5
Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study. ( 29731693 )
2018
6
The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. ( 29412487 )
2018
7
Hepatitis C screening in patients with oral lichen planus. ( 29971956 )
2018
8
Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. ( 29405515 )
2018
9
Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. ( 29350426 )
2018
10
Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus. ( 29414735 )
2018
11
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
12
Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus. ( 29854885 )
2018
13
Comment on "Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids". ( 29760823 )
2018
14
Oral lichen planus and HPV lesions. ( 29875955 )
2018
15
Rate of malignant transformation of oral lichen planus: A systematic review. ( 29738106 )
2018
16
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
17
Expression and clinical significance of periostin in oral lichen planus. ( 29805541 )
2018
18
Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. ( 29875865 )
2018
19
Lack of Association between Oral Lichen Planus and Hepatitis B and C Virus Infection - a Report from Southeast Iran ( 29936791 )
2018
20
Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. ( 29967591 )
2018
21
Dental Implants and Oral Lichen Planus. ( 29801195 )
2018
22
Alterations of Serum Lipid Profile Patterns in Oral Lichen Planus Patients: A Case-Control Study. ( 29962775 )
2018
23
Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus. ( 29436013 )
2018
24
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus. ( 29335479 )
2018
25
Association between TNFI+ - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis. ( 29641751 )
2018
26
Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study. ( 29345111 )
2018
27
Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients. ( 29368136 )
2018
28
Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. ( 29366304 )
2018
29
Multiple keratoacanthoma and oral lichen planus successfully treated with systemic retinoids and review of multiple keratoacanthoma associated with lichen planus. ( 29577263 )
2018
30
Effectiveness of 904nm Gallium-Arsenide Diode Laser in Treatment of Oral Lichen Planus: Report of 2Cases. ( 29857947 )
2018
31
Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus. ( 29852392 )
2018
32
Psychopathological profile and quality of life of patients with oral lichen planus. ( 29364344 )
2018
33
Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments ( 29801395 )
2018
34
Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential. ( 29731815 )
2018
35
Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study. ( 29391729 )
2017
36
Letter to the Editor: Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL? ( 28160592 )
2017
37
Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia. ( 29391726 )
2017
38
TLR4-induced B7-H1 on keratinocytes negatively regulates CD4<sup>+</sup> T cells and CD8<sup>+</sup> T cells responses in oral lichen planus. ( 27762043 )
2017
39
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma ( 28749626 )
2017
40
The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus? ( 28869787 )
2017
41
Association between -1082a88A/G polymorphism in IL-10 and oral lichen planus: A meta-analysis. ( 28094099 )
2017
42
Activated Akt/mTOR-autophagy in local T cells of oral lichen planus. ( 28482233 )
2017
43
Evaluation of oxidative stress markers in oral lichen planus. ( 29391713 )
2017
44
Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma. ( 29430221 )
2017
45
Evidence of genetic factors involved in oral lichen planus pathogenesis. ( 28736881 )
2017
46
Caveolin-1 expression in oral lichen planus, dysplastic lesions and squamous cell carcinoma. ( 28554768 )
2017
47
Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. ( 28779221 )
2017
48
Treatment of oral lichen planus. Systematic review and therapeutic guide. ( 28756997 )
2017
49
Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis. ( 29744205 )
2017
50
Incidence of Oral Lichen Planus in Perimenopausal Women: A Cross-sectional Study in Western Uttar Pradesh Population. ( 28706407 )
2017

Variations for Oral Lichen Planus

Expression for Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for Oral Lichen Planus

Pathways related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 CASP3 CCL5 CCR5 CD58 HSPA8 ICAM1
2
Show member pathways
13.27 CASP3 CCL5 CCR5 CXCR3 ICAM1 MMP1
3
Show member pathways
13.26 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
4
Show member pathways
13.07 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
5
Show member pathways
13.03 CASP3 CCL5 CCR5 HSPA8 ICAM1 IL1A
6
Show member pathways
12.75 CASP3 HSPA8 HSPD1 ICAM1 IL1A
7
Show member pathways
12.66 CASP3 CCL5 HSPA8 ICAM1 IL1A
8
Show member pathways
12.6 CASP3 ICAM1 MMP1 TIMP2 VCAM1
9
Show member pathways
12.44 BAX CASP3 CCR5 ICAM1
10
Show member pathways
12.11 CASP3 CCR5 HSPA8 IL1A
11
Show member pathways
12.08 BAX CASP3 IL1A
12 12.08 BAX CASP3 HSPD1 IL1A
13 12.07 BAX CASP3 MMP1
14 12.06 CASP3 HSPD1 IL1A
15 12.03 BAX CASP3 MMP1
16 11.99 CD58 ICAM1 VCAM1
17 11.97 ICAM1 IL1A VCAM1
18
Show member pathways
11.91 BAX CASP3 TP63
19
Show member pathways
11.91 BAX CCL5 ICAM1 IL1A TIMP2
20 11.89 CASP3 ICAM1 IL1A
21
Show member pathways
11.86 CCL5 CCR5 CXCR3
22 11.74 CASP3 CCL5 ICAM1 VCAM1
23
Show member pathways
11.7 BAX CASP3 VCAM1
24 11.69 BAX ICAM1 MMP1
25 11.62 CCL5 ICAM1 IL1A MMP1
26 11.47 CASP3 HSPA8 HSPD1
27 11.41 HSPA8 ICAM1 IL1A MMP1 VCAM1
28
Show member pathways
11.36 ICAM1 IL1A MMP1 VCAM1
29 11.35 BAX CASP3 MMP1
30 11.24 CCL5 MMP1 TIMP2
31 11.15 BAX CCL5 IL1A
32 11.15 CCL5 CCR5 ICAM1 IL1A
33 11.07 ICAM1 TIMP2
34 11.02 BAX CASP3
35 11.02 BAX CASP3 ICAM1 IL1A VCAM1
36
Show member pathways
11 BAX TP63
37 10.87 CCL5 MMP1
38 10.83 ICAM1 VCAM1

GO Terms for Oral Lichen Planus

Cellular components related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CCL5 HSPA8 HSPD1 ICAM1 IL1A TIMP2
2 external side of plasma membrane GO:0009897 9.26 CCR5 CXCR3 ICAM1 VCAM1
3 cell surface GO:0009986 9.17 CCR5 CD58 CXCR3 HSPD1 ICAM1 TIMP2

Biological processes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.97 BAX CASP3 CXCR3 IL1A TP63
2 inflammatory response GO:0006954 9.91 CCL5 CCR5 CXCR3 IL1A
3 response to hypoxia GO:0001666 9.82 CASP3 ICAM1 VCAM1
4 chemotaxis GO:0006935 9.82 CCL5 CCR5 CXCR3
5 cell-cell adhesion GO:0098609 9.78 CD58 ICAM1 VCAM1
6 cellular response to interferon-gamma GO:0071346 9.73 CCL5 CD58 ICAM1
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.72 BAX CASP3 HSPD1
8 chemokine-mediated signaling pathway GO:0070098 9.7 CCL5 CCR5 CXCR3
9 response to tumor necrosis factor GO:0034612 9.65 CASP3 CCL5
10 protein refolding GO:0042026 9.64 HSPA8 HSPD1
11 regulation of neuron apoptotic process GO:0043523 9.63 BAX TP63
12 response to X-ray GO:0010165 9.63 CASP3 TP63
13 response to ionizing radiation GO:0010212 9.63 BAX ICAM1 VCAM1
14 B cell homeostasis GO:0001782 9.62 BAX CASP3
15 apoptotic mitochondrial changes GO:0008637 9.62 BAX HSPD1
16 dendritic cell chemotaxis GO:0002407 9.6 CCL5 CCR5
17 positive regulation of protein oligomerization GO:0032461 9.59 BAX MMP1
18 response to copper ion GO:0046688 9.58 ICAM1 IL1A
19 cellular response to organic substance GO:0071310 9.58 BAX CASP3 ICAM1
20 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.57 BAX TP63
21 cellular response to tumor necrosis factor GO:0071356 9.56 CCL5 CD58 ICAM1 VCAM1
22 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.54 BAX CASP3
23 neuron apoptotic process GO:0051402 9.54 BAX CASP3 TP63
24 ectopic germ cell programmed cell death GO:0035234 9.51 BAX IL1A
25 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.5 BAX CASP3 IL1A
26 viral process GO:0016032 9.5 BAX CCR5 HSPA8 HSPD1 ICAM1 MMP1
27 negative regulation of macrophage apoptotic process GO:2000110 9.49 CCL5 CCR5
28 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
29 adhesion of symbiont to host GO:0044406 9.43 HSPD1 ICAM1
30 leukocyte cell-cell adhesion GO:0007159 9.33 CCL5 ICAM1 VCAM1
31 cytokine-mediated signaling pathway GO:0019221 9.23 CASP3 CCL5 CCR5 HSPA8 ICAM1 IL1A

Molecular functions related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.26 CCL5 CCR5
2 chemokine receptor activity GO:0004950 9.16 CCR5 CXCR3
3 integrin binding GO:0005178 9.13 ICAM1 TIMP2 VCAM1
4 chaperone binding GO:0051087 8.8 BAX HSPA8 HSPD1

Sources for Oral Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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