MCID: ORL013
MIFTS: 51

Oral Lichen Planus

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Oral Lichen Planus

MalaCards integrated aliases for Oral Lichen Planus:

Name: Oral Lichen Planus 53
Oral Lichenoid Lesions 53
Lichen Planus, Oral 73
Lichen Planus Oral 55

Classifications:



External Ids:

UMLS 73 C0206139

Summaries for Oral Lichen Planus

NIH Rare Diseases : 53 Oral lichen planus is a inflammatory condition that affects the inside of the mouth.  Signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. Most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. Severe lichen planus slightly increases the risk for oral cancer. Oral lichen planus may occur alone or in combination with other skin forms of lichen planus.

MalaCards based summary : Oral Lichen Planus, also known as oral lichenoid lesions, is related to rheumatoid arthritis and systemic lupus erythematosus, and has symptoms including oral manifestations An important gene associated with Oral Lichen Planus is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and t cells, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and cardiovascular system

Related Diseases for Oral Lichen Planus

Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.8 CCL5 ICAM1 IL1A MMP1 VCAM1
2 systemic lupus erythematosus 29.7 CCL5 CCR5 CXCR3 ICAM1 VCAM1
3 lichen planus 11.5
4 hepatitis 10.8
5 hepatitis c 10.8
6 squamous cell carcinoma 10.8
7 hepatitis c virus 10.7
8 oral squamous cell carcinoma 10.7
9 leukoplakia 10.6
10 viral infectious disease 10.5
11 stomatitis 10.5
12 oral leukoplakia 10.4
13 gingivitis 10.4
14 pemphigus 10.4
15 oral cancer 10.4
16 depression 10.4
17 burning mouth syndrome 10.4
18 pemphigus vulgaris, familial 10.3
19 anxiety 10.3
20 pemphigus vulgaris 10.3
21 aphthous stomatitis 10.3
22 sutton disease 2 10.3
23 hepatitis b 10.3
24 candidiasis 10.3
25 papilloma 10.3
26 periodontitis 10.3
27 oral erosive lichen 10.3
28 lymphocytic vasculitis 10.2 ICAM1 VCAM1
29 heterophyiasis 10.2 CASP3 ICAM1
30 mooren's ulcer 10.2 ICAM1 VCAM1
31 shwartzman phenomenon 10.2 ICAM1 VCAM1
32 whiplash 10.2 CCL5 CCR5
33 mucositis 10.2
34 subendocardial myocardial infarction 10.2 ICAM1 VCAM1
35 vulvovaginitis 10.2 CCL5 HSPD1
36 brachydactyly, type e2 10.2 ICAM1 VCAM1
37 dengue disease 10.2 CCL5 ICAM1 VCAM1
38 trypanosomiasis 10.2 CCL5 ICAM1 VCAM1
39 immune-complex glomerulonephritis 10.2 CCR5 ICAM1 VCAM1
40 chronic nk-cell lymphocytosis 10.2 CCL5 CCR5
41 rhinitis 10.1 CCL5 ICAM1 VCAM1
42 crescentic glomerulonephritis 10.1 CCR5 ICAM1 VCAM1
43 idiopathic neutropenia 10.1 CASP3 CCL5 IL1A
44 chronic conjunctivitis 10.1 CCL5 ICAM1
45 respiratory system disease 10.1 CASP3 CCL5 ICAM1
46 rheumatoid vasculitis 10.1 ICAM1 VCAM1
47 autoimmune disease 10.1
48 biliary cirrhosis, primary, 1 10.1
49 pemphigus foliaceus 10.1
50 primary biliary cirrhosis 10.1

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to Oral Lichen Planus

Symptoms & Phenotypes for Oral Lichen Planus

UMLS symptoms related to Oral Lichen Planus:


oral manifestations

GenomeRNAi Phenotypes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.8 CD58 HSPD1 IL1A

MGI Mouse Phenotypes related to Oral Lichen Planus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CASP3 CCR5 CXCR3 ICAM1 IL1A TIMP2
2 hematopoietic system MP:0005397 9.97 BAX CASP3 CCL5 CCR5 CXCR3 ICAM1
3 homeostasis/metabolism MP:0005376 9.96 BAX CASP3 CCR5 CXCR3 ICAM1 IL1A
4 immune system MP:0005387 9.9 BAX CASP3 CCL5 CCR5 CXCR3 ICAM1
5 muscle MP:0005369 9.43 BAX CASP3 CCR5 HSPD1 ICAM1 TP63
6 neoplasm MP:0002006 9.17 BAX CCR5 CXCR3 ICAM1 IL1A MMP1

Drugs & Therapeutics for Oral Lichen Planus

Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 124-94-7 31307
2
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
3 tannic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
4
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492
5
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 22916-47-8 4189
8
Chitosan Approved Phase 4 9012-76-4 71853
9
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
13 Lycopene Approved, Investigational Phase 4,Phase 2 502-65-8 446925
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
15
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
16
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7
17
Lactitol Investigational Phase 4 585-86-4 3871
18 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
21 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
27 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
28 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
29 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
31 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
35 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
37 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
38 Dermatologic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
39 Analgesics Phase 4,Phase 3,Phase 2
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2
41 Chlorhexidine gluconate Phase 4
42 Methylprednisolone acetate Phase 4,Phase 2
43 Radiation-Protective Agents Phase 4,Phase 2
44 Prednisolone acetate Phase 4,Phase 2
45 Neuroprotective Agents Phase 4
46 Carotenoids Phase 4,Phase 2
47 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
48 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2
49 Antifungal Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
50 Betamethasone benzoate Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
6 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
7 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
8 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
9 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
11 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
12 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
13 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
14 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
15 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
16 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
17 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
18 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
19 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
20 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
21 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
22 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
23 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
24 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
25 Intra-oral Treatment of OLP With Rivelin®-CLO Patches Recruiting NCT03592342 Phase 2 Clobetasol Propionate
26 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Active, not recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
27 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
28 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Not yet recruiting NCT03509675 Phase 2 Non-Steroidal Anti-inflammatory Topical Rinse;Placebos
29 THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus Not yet recruiting NCT03656666 Phase 2 Apremilast;Placebo
30 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
31 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
32 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
33 Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus Not yet recruiting NCT03793634 Phase 1 topical chamomile
34 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573 Not Applicable
35 Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study Unknown status NCT02332486 Not Applicable Qingxuan Decoction
36 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable
37 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
38 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Completed NCT03011658 Not Applicable
39 The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2) Completed NCT03257228
40 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607 Not Applicable
41 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690 Not Applicable Nystatin;fluocinolone
42 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
43 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107 Not Applicable efalizumab
44 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
45 Treatment Modalities of Oral Lichen Planus Recruiting NCT03237533 Early Phase 1 Dexamethasone
46 Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus Recruiting NCT03415165 Early Phase 1 green tea buccal tablet;Corticosteroids Topical
47 Photobiomodulation in Oral Lichen Planus Recruiting NCT03320460 Not Applicable Propionate clobetasol gel 0.05%
48 Use of Injectable Platelet Rich Fibrin in Lichen Planus Recruiting NCT03265093 Not Applicable Corticosteroid
49 Lichen Planus and Mean Platelet Volum Active, not recruiting NCT03687437
50 Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients Active, not recruiting NCT03529604

Search NIH Clinical Center for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

MalaCards organs/tissues related to Oral Lichen Planus:

41
Tongue, Skin, T Cells, Thyroid, Testes, Bone, Nk Cells

Publications for Oral Lichen Planus

Articles related to Oral Lichen Planus:

(show top 50) (show all 1156)
# Title Authors Year
1
Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial. ( 29909565 )
2018
2
Participation of the Th17 response in the pathogenesis of oral lichen planus. ( 29314294 )
2018
3
Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus. ( 29297958 )
2018
4
MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). ( 29813046 )
2018
5
Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study. ( 29731693 )
2018
6
The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. ( 29412487 )
2018
7
Hepatitis C screening in patients with oral lichen planus. ( 29971956 )
2018
8
Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. ( 29405515 )
2018
9
Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. ( 29350426 )
2018
10
Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus. ( 29414735 )
2018
11
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
12
Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus. ( 29854885 )
2018
13
Comment on "Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids". ( 29760823 )
2018
14
Oral lichen planus and HPV lesions. ( 29875955 )
2018
15
Rate of malignant transformation of oral lichen planus: A systematic review. ( 29738106 )
2018
16
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
17
Expression and clinical significance of periostin in oral lichen planus. ( 29805541 )
2018
18
Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. ( 29875865 )
2018
19
Lack of Association between Oral Lichen Planus and Hepatitis B and C Virus Infection - a Report from Southeast Iran ( 29936791 )
2018
20
Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. ( 29967591 )
2018
21
Dental Implants and Oral Lichen Planus. ( 29801195 )
2018
22
Alterations of Serum Lipid Profile Patterns in Oral Lichen Planus Patients: A Case-Control Study. ( 29962775 )
2018
23
Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus. ( 29436013 )
2018
24
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus. ( 29335479 )
2018
25
Association between TNFI+ - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis. ( 29641751 )
2018
26
Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study. ( 29345111 )
2018
27
Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients. ( 29368136 )
2018
28
Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. ( 29366304 )
2018
29
Multiple keratoacanthoma and oral lichen planus successfully treated with systemic retinoids and review of multiple keratoacanthoma associated with lichen planus. ( 29577263 )
2018
30
Effectiveness of 904nm Gallium-Arsenide Diode Laser in Treatment of Oral Lichen Planus: Report of 2Cases. ( 29857947 )
2018
31
Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus. ( 29852392 )
2018
32
Psychopathological profile and quality of life of patients with oral lichen planus. ( 29364344 )
2018
33
Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments ( 29801395 )
2018
34
Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential. ( 29731815 )
2018
35
Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients. ( 29570907 )
2018
36
Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus. ( 30327948 )
2018
37
Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: a randomized controlled trial. ( 30507032 )
2018
38
Interferon gamma and interleukin 8 gene polymorphisms in patients with hepatitis C virus related oral lichen planus. ( 30290294 )
2018
39
Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP. ( 29984679 )
2018
40
Deregulated phospholipase D2/mammalian target of rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with disease severity. ( 30419486 )
2018
41
Different expression patterns of carbonic anhydrase IX in oral lichen planus and leukoplakia. ( 30383070 )
2018
42
The effects of photodynamic and low-level laser therapy for treatment of oral lichen planus-A systematic review and meta-analysis. ( 30006319 )
2018
43
Vitamin D/VDR signaling suppresses microRNA-802-induced apoptosis of keratinocytes in oral lichen planus. ( 30074824 )
2018
44
Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. ( 30110084 )
2018
45
Forkhead box p3 controls progression of oral lichen planus by regulating microRNA-146a. ( 30125971 )
2018
46
Carcinoma cuniculatum in the tongue of a patient with oral lichen planus: Unusual presentation. ( 30127207 )
2018
47
The oral microbiome in oral lichen planus during a 1-year randomized clinical trial. ( 30144242 )
2018
48
Phenotypic alteration of basal cells in oral lichen planus; switching keratin 19 and desmoglein 1 expression. ( 30146538 )
2018
49
Comparing Vitamin D Serum Levels in Patients with Oral Lichen Planus and Healthy Subjects. ( 30175191 )
2018
50
Factors affecting treatment outcomes in patients with oral lichen planus lesions: a retrospective study of 113 cases. ( 30202605 )
2018

Variations for Oral Lichen Planus

Expression for Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for Oral Lichen Planus

Pathways related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CASP3 CCL5 CCR5 CD58 HSPA8 ICAM1
2
Show member pathways
13.27 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
3
Show member pathways
13.25 CASP3 CCL5 CCR5 CXCR3 ICAM1 MMP1
4
Show member pathways
13.09 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
5
Show member pathways
13.08 CASP3 CCL5 CCR5 HSPA8 ICAM1 IL1A
6
Show member pathways
12.92 BAX CASP3 CCL5 CCR5 ICAM1
7
Show member pathways
12.76 CASP3 HSPA8 HSPD1 ICAM1 IL1A
8
Show member pathways
12.69 CASP3 CCL5 HSPA8 ICAM1 IL1A
9
Show member pathways
12.61 CASP3 ICAM1 MMP1 TIMP2 VCAM1
10
Show member pathways
12.56 BAX CASP3 CCR5 IL1A
11 12.19 BAX CASP3 CD58 ICAM1
12
Show member pathways
12.12 CASP3 CCR5 HSPA8 IL1A
13 12.09 BAX CASP3 HSPD1 IL1A
14 12.08 BAX CASP3 MMP1
15 12.07 CASP3 HSPD1 IL1A
16 12.04 BAX CASP3 MMP1
17 11.99 CD58 ICAM1 VCAM1
18 11.97 ICAM1 IL1A VCAM1
19
Show member pathways
11.92 BAX CASP3 TP63
20
Show member pathways
11.91 BAX CCL5 ICAM1 IL1A TIMP2
21 11.89 CASP3 ICAM1 IL1A
22
Show member pathways
11.87 CCL5 CCR5 CXCR3
23 11.78 CASP3 CCL5 ICAM1 VCAM1
24
Show member pathways
11.71 BAX CASP3 VCAM1
25 11.7 BAX ICAM1 MMP1
26 11.66 CCL5 ICAM1 IL1A MMP1
27 11.61 HSPA8 ICAM1 IL1A MMP1 VCAM1
28 11.51 CASP3 HSPA8 HSPD1
29
Show member pathways
11.42 ICAM1 IL1A MMP1 VCAM1
30 11.36 BAX CASP3 MMP1
31 11.35 BAX CASP3 ICAM1 IL1A VCAM1
32
Show member pathways
11.33 BAX CCL5 CCR5 CXCR3 ICAM1 IL1A
33 11.28 CCL5 MMP1 TIMP2
34 11.25 CCL5 CCR5 ICAM1 IL1A
35 11.18 BAX CCL5 IL1A
36 11.07 ICAM1 TIMP2
37 11.03 BAX CASP3
38
Show member pathways
11 BAX TP63
39 10.88 CCL5 MMP1
40 10.84 ICAM1 VCAM1

GO Terms for Oral Lichen Planus

Cellular components related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CCL5 HSPA8 HSPD1 ICAM1 IL1A TIMP2
2 external side of plasma membrane GO:0009897 9.46 CCR5 CXCR3 ICAM1 VCAM1
3 cell surface GO:0009986 9.17 CCR5 CD58 CXCR3 HSPD1 ICAM1 TIMP2

Biological processes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL5 CCR5 CXCR3 IL1A
2 response to drug GO:0042493 9.9 CASP3 HSPD1 ICAM1 TIMP2
3 chemotaxis GO:0006935 9.83 CCL5 CCR5 CXCR3
4 cell-cell adhesion GO:0098609 9.82 CD58 ICAM1 VCAM1
5 response to organic cyclic compound GO:0014070 9.81 CASP3 HSPD1 ICAM1
6 response to hypoxia GO:0001666 9.78 CASP3 HSPD1 ICAM1 VCAM1
7 cellular response to interferon-gamma GO:0071346 9.77 CCL5 CD58 ICAM1
8 response to organic substance GO:0010033 9.76 CASP3 HSPD1 TIMP2
9 response to lipopolysaccharide GO:0032496 9.76 CASP3 HSPD1 ICAM1 VCAM1
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.75 BAX CASP3 HSPD1
11 chemokine-mediated signaling pathway GO:0070098 9.74 CCL5 CCR5 CXCR3
12 cellular response to heat GO:0034605 9.72 HSPA8 HSPD1 IL1A
13 response to ionizing radiation GO:0010212 9.67 BAX ICAM1 VCAM1
14 cellular response to unfolded protein GO:0034620 9.66 BAX HSPA8
15 protein refolding GO:0042026 9.65 HSPA8 HSPD1
16 B cell homeostasis GO:0001782 9.65 BAX CASP3
17 apoptotic mitochondrial changes GO:0008637 9.64 BAX HSPD1
18 dendritic cell chemotaxis GO:0002407 9.63 CCL5 CCR5
19 response to copper ion GO:0046688 9.62 ICAM1 IL1A
20 positive regulation of protein oligomerization GO:0032461 9.62 BAX MMP1
21 cellular response to tumor necrosis factor GO:0071356 9.62 CCL5 CD58 ICAM1 VCAM1
22 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.61 BAX TP63
23 cellular response to organic substance GO:0071310 9.61 BAX CASP3 ICAM1
24 neuron apoptotic process GO:0051402 9.58 BAX CASP3 TP63
25 ectopic germ cell programmed cell death GO:0035234 9.56 BAX IL1A
26 negative regulation of macrophage apoptotic process GO:2000110 9.54 CCL5 CCR5
27 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.54 BAX CASP3 IL1A
28 membrane to membrane docking GO:0022614 9.52 ICAM1 VCAM1
29 adhesion of symbiont to host GO:0044406 9.51 HSPD1 ICAM1
30 cell chemotaxis GO:0060326 9.46 CCL5 CCR5 CXCR3 VCAM1
31 leukocyte cell-cell adhesion GO:0007159 9.43 CCL5 ICAM1 VCAM1
32 viral process GO:0016032 9.43 BAX CCR5 HSPA8 HSPD1 ICAM1 MMP1
33 cytokine-mediated signaling pathway GO:0019221 9.23 CASP3 CCL5 CCR5 HSPA8 ICAM1 IL1A
34 apoptotic process GO:0006915 10.01 BAX CASP3 CXCR3 IL1A TP63

Molecular functions related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.43 CCL5 CCR5
2 chemokine binding GO:0019956 9.4 CCR5 CXCR3
3 C-C chemokine binding GO:0019957 9.37 CCR5 CXCR3
4 integrin binding GO:0005178 9.33 ICAM1 TIMP2 VCAM1
5 C-C chemokine receptor activity GO:0016493 9.32 CCR5 CXCR3
6 chemokine receptor activity GO:0004950 9.26 CCR5 CXCR3
7 chaperone binding GO:0051087 9.13 BAX HSPA8 HSPD1
8 protease binding GO:0002020 8.8 CASP3 HSPD1 TIMP2

Sources for Oral Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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