MCID: ORL013
MIFTS: 45

Oral Lichen Planus

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Oral Lichen Planus

MalaCards integrated aliases for Oral Lichen Planus:

Name: Oral Lichen Planus 20 17
Oral Lichenoid Lesions 20
Lichen Planus, Oral 70
Lichen Planus Oral 54

Classifications:



External Ids:

UMLS 70 C0206139

Summaries for Oral Lichen Planus

GARD : 20 Oral lichen planus is a inflammatory condition that affects the inside of the mouth. Signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. Most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. Severe lichen planus slightly increases the risk for oral cancer. Oral lichen planus may occur alone or in combination with other skin forms of lichen planus.

MalaCards based summary : Oral Lichen Planus, also known as oral lichenoid lesions, is related to gingivitis and chronic graft versus host disease, and has symptoms including oral manifestations An important gene associated with Oral Lichen Planus is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include tongue, t cells and endothelial, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and cardiovascular system

Related Diseases for Oral Lichen Planus

Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 gingivitis 31.2 MMP1 IL1A CCL5
2 chronic graft versus host disease 30.8 IL1A CCR5 CCL5
3 contact dermatitis 30.6 VCAM1 IL1A ICAM1 CXCR3
4 proteasome-associated autoinflammatory syndrome 1 30.6 VCAM1 IL1A ICAM1 CCL5
5 allergic contact dermatitis 30.5 VCAM1 ICAM1 CXCR3
6 dermatitis 30.4 IL1A ICAM1 CXCR3 CCL5
7 keratoconjunctivitis 30.3 MMP1 ICAM1 CCL5
8 autoimmune disease 30.2 VCAM1 IL1A HSPD1 CXCR3 CD58 CCR5
9 viral infectious disease 30.1 ICAM1 CXCR3 CCR5 CCL5
10 dermatitis, atopic 30.1 VCAM1 IL1A ICAM1 CXCR3 CCL5
11 graves' disease 30.0 IL1A ICAM1 CXCR3 CCL5
12 skin disease 29.8 TP63 MMP1 IL1A ICAM1 HSPA4 CXCR3
13 arthritis 29.6 VCAM1 MMP1 IL1A ICAM1 HSPD1 CCL5
14 systemic lupus erythematosus 29.5 VCAM1 IL1A ICAM1 HSPD1 CXCR3 CCR5
15 psoriasis 29.4 VCAM1 IL1A ICAM1 CXCR3 CD58 CCL5
16 sarcoidosis 1 29.4 IL1A ICAM1 HSPA4 CXCR3 CCR5 CCL5
17 psoriatic arthritis 29.2 MMP1 IL1A CD58
18 inflammatory bowel disease 28.8 VCAM1 MMP1 IL1A ICAM1 HSPD1 HSPA4
19 rheumatoid arthritis 28.7 VCAM1 TIMP2 MMP1 IL1A ICAM1 HSPD1
20 lichen planus 11.7
21 oral squamous cell carcinoma 11.1
22 oral cancer 10.9
23 hepatitis c virus 10.9
24 squamous cell carcinoma 10.9
25 leukoplakia 10.9
26 hepatitis c 10.8
27 candidiasis 10.7
28 keratosis 10.7
29 oral leukoplakia 10.7
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.7
31 stomatitis 10.7
32 mucositis 10.6
33 hypothyroidism 10.6
34 pemphigoid 10.6
35 oral candidiasis 10.6
36 pemphigus 10.6
37 graft-versus-host disease 10.6
38 hepatitis 10.6
39 burning mouth syndrome 10.5
40 periodontitis 10.5
41 aphthous stomatitis 10.5
42 cytokine deficiency 10.5
43 pemphigus vulgaris, familial 10.5
44 squamous cell papilloma 10.5
45 papilloma 10.5
46 sutton disease 2 10.5
47 anxiety 10.4
48 vitamin b12 deficiency 10.4
49 allergic disease 10.4
50 thyroid gland disease 10.4

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to Oral Lichen Planus

Symptoms & Phenotypes for Oral Lichen Planus

UMLS symptoms related to Oral Lichen Planus:


oral manifestations

GenomeRNAi Phenotypes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.8 CD58 HSPD1 IL1A

MGI Mouse Phenotypes related to Oral Lichen Planus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CASP3 CCR5 CXCR3 HSPD1 ICAM1 IL1A
2 hematopoietic system MP:0005397 9.85 BAX CASP3 CCL5 CCR5 CXCR3 HSPD1
3 immune system MP:0005387 9.7 BAX CASP3 CCL5 CCR5 CXCR3 ICAM1
4 neoplasm MP:0002006 9.17 BAX CCR5 CXCR3 ICAM1 IL1A MMP1

Drugs & Therapeutics for Oral Lichen Planus

Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
7
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
8
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
13
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
14
Lycopene Approved, Investigational Phase 4 502-65-8 446925
15
Lactitol Approved, Investigational Phase 4 585-86-4 157355
16
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
17
Zinc Approved, Investigational Phase 4 7440-66-6 32051
18
Chitosan Experimental Phase 4 9012-76-4 71853
19
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
20
Pomegranate Experimental, Investigational Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Hormone Antagonists Phase 4
23 glucocorticoids Phase 4
24 Antirheumatic Agents Phase 4
25 Hormones Phase 4
26 Analgesics Phase 4
27 Anti-Inflammatory Agents Phase 4
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Respiratory System Agents Phase 4
31 Betamethasone Valerate Phase 4 2152-44-5
32 Betamethasone benzoate Phase 4
33 Betamethasone sodium phosphate Phase 4
34 Betamethasone-17,21-dipropionate Phase 4
35 Immunologic Factors Phase 4
36 Chlorhexidine gluconate Phase 4
37 Immunosuppressive Agents Phase 4
38 Antifungal Agents Phase 4
39 Antineoplastic Agents, Hormonal Phase 4
40 Calcineurin Inhibitors Phase 4
41 Dermatologic Agents Phase 4
42 Protective Agents Phase 4
43 Methylprednisolone Acetate Phase 4
44 Radiation-Protective Agents Phase 4
45 Triamcinolone diacetate Phase 4
46 triamcinolone acetonide Phase 4
47 Triamcinolone hexacetonide Phase 4
48 Trace Elements Phase 4
49 Nutrients Phase 4
50 Micronutrients Phase 4

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Patients: A Comparative Pilot Study Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus: A Pilot, Randomized, Clinical and Immunohistochemical Trial Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus: A Randomized, Double Blind Clinical Trial Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial) Completed NCT04193748 Phase 4 Topical pomegranate seeds and peel extracts
5 A Comparative Clinical and Immunohistochemical Study Between Topical Pimecrolimus and Corticosteroid in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
6 Comparative Evaluation of Effect of Oral Zinc Supplementation and Placebo as an Adjuvant to Topical Corticosteroid Therapy in Oral Lichen Planus Patients Recruiting NCT04278599 Phase 4 Oral Zinc supplementation;Oral placebo supplementation
7 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
8 Use of Topical Non-Steroidal Anti- Inflammatory to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Completed NCT03509675 Phase 2, Phase 3 Ibuprofen suspension 5mg/100ml;Placebos
9 Evaluation of Systemic Administration of Green Tea Polyphenols as a Supportive Antioxidant Agent in the Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
10 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treatment Oral LichenPlanus Completed NCT02421770 Phase 3
11 Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus (A Randomized Clinical Trial) Completed NCT04652739 Phase 2, Phase 3 Lycopene Softgel, 10 Mg;Prednisolone
12 Randomized Placebo-Controlled Clinical Pilot Trial Regarding the Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
13 Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus. A Multicenter Placebo-controlled Randomized Clinical Trial. Recruiting NCT04364555 Phase 2, Phase 3 Clobetasol Propionate;Placebo/active;Placebo/placebo
14 Efficacy of Topical Rapamycin in Treatment of Chronic Erosive Oral Lichen Planus. Double Blind Randomised Controlled Trial Rapamycin vs Topical Steroids Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
15 A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus Unknown status NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
16 Efficacy of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids on Pain Relief and Ulcers Healing in Patients With Erosive Oral Lichen Planus; Randomized Clinical Trial Unknown status NCT03293368 Phase 2 Triamcinolone Acetonide
17 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
18 Cedar Honey in Treatment of Oral Lichen Planus: a Randomized Clinical Trial Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
19 Treatment of Oral Lichen Planus Lesions Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
20 A Randomized, Placebo-Controlled, Double-Blind Trial of a Two Week Course of Curcuminoids in Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
21 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
22 A 6-week Randomized, Double-blind, Vehicle-controlled Pilot Study With a 6-week Open Label Extension to Assess the Efficacy and Safety of Pimecrolimus 1% Cream in the Treatment of Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
23 A Randomized, Double-blind, Placebo-controlled, Parallel Group Clinical Study to Assess the Safety and Efficacy of Three Doses of Clobetasol Propionate When Administered Intra-orally Twice Daily in Patients With Oral Lichen Planus (OLP) Using Rivelin®-CLO Patches Completed NCT03592342 Phase 2 Clobetasol Propionate
24 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus- A Double-blinded Randomized Clinical Trial in Sri Lanka Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
25 Dexamethasone 0.01% Solution for the Treatment of Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
26 Effect of the Probiotic Bifidobacterium Animalis Subsp. Lactis HN019 on Clinical, Histopathological and Immunophenotypic Features of Oral Lichen Planus Completed NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
27 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus and Improvement of Quality of Life: A Randomized, Double Blind, Controlled Study Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
28 Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
29 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on the Duration and Symptoms of Lesions That Caused by Symptomatic Oral Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
30 Hydroxychloroquine Versus Clobetasol 0.05% Rinse for the Treatment of Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
31 Dexamethasone Solution and Dexamethasone in Mucolox™ for the Treatment of Oral Lichen Planus Completed NCT02850601 Phase 2 Dexamethasone
32 Efficacy of Oral Lycopene in the Management of Oral Lichen Planus Completed NCT00656214 Phase 2 Lycopene;Placebo
33 Dexamethasone Solution and Dexamethasone in Mucolox™ for the Treatment of Oral Inflammatory Ulcerative Diseases Recruiting NCT04540133 Phase 2 dexamethasone 0.5mg/5ml solution;dexamethasone 0.5mg/5ml solution in Mucolox™
34 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
35 The APOLP Trial: A Single-Center, Randomized, 16 Weeks, Explanatory, Parallel-Group, Superiority, Blinded, Placebo-Controlled, Clinical Trial of Apremilast Use in Oral Lichen Planus Withdrawn NCT03836885 Phase 2 Apremilast;Placebo
36 The Effect of Topical Curcumin Versus Topical Corticosteroid on Pain, Clinical Parameters and Salivary Level of IL-33 in Oral Lichen Planus Patients: A Randomized Controlled Clinical Trial Unknown status NCT03877679 Phase 1 Triamcinolone;Turmeric paste
37 Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus Unknown status NCT03793634 Phase 1 topical chamomile
38 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
39 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
40 Evaluation of Salivary Total Oxidant Capacity in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid Supplemented With Vitamin E Versus Topical Corticosteroid Alone Completed NCT04126720 Phase 1 Topical corticosteroid and placebo capsules
41 11 El-Saraya St. - Manial - Cairo Not yet recruiting NCT04091698 Phase 1 Co-Enzyme Q10 mucoadhesive tablets
42 The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker, Malondialdehyde [MDA] : Randomized Clinical Trial (RCT) Unknown status NCT03738176 Early Phase 1 Sesame Oil;triamcinolone in orabase
43 Based on Metabonomics Dryness Pathogen Type of Oral Lichen Planus of Dynamic Unknown status NCT02332486 Qingxuan Decoction
44 Efficacy of 200mg and 300mg Concentrates of Green Tea Polyphenols Using Buccal Tablets Versus Topical Application of Corticosteroids in Treatment of Patients With Symptomic Oral Lichen Planus Randomized Clinical Trial Unknown status NCT03415165 Early Phase 1 green tea buccal tablet;Corticosteroids Topical
45 Comparative Efficacy of Dexamethasone, Doxycycline, Nystatin and Promethazine With Triamcinolone in Orabase as Symptomatic Treatment of Oral Lichen Planus, A Randomized Controlled Trial Unknown status NCT03237533 Early Phase 1 Dexamethasone
46 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573
47 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus. Diagnostic Value of White Light Endoscopy, Narrow Band Imaging and Chromoendoscopy for Detection of Esophageal Manifestation in Patients With Oral Lichen. Unknown status NCT02532166
48 Efficacy of Photobiomodulation for Oral Lichen Planus Treatment Unknown status NCT03320460 Propionate clobetasol gel 0.05%
49 Association of Oral Lichen Planus and Thyroid Disease Completed NCT04523077
50 Clinical Trial Analyzing the Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus Completed NCT02154607

Search NIH Clinical Center for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

MalaCards organs/tissues related to Oral Lichen Planus:

40
Tongue, T Cells, Endothelial, Thyroid, Salivary Gland, Bone Marrow, Liver

Publications for Oral Lichen Planus

Articles related to Oral Lichen Planus:

(show top 50) (show all 2842)
# Title Authors PMID Year
1
Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma. 54 61
19751907 2009
2
[Expressions of proliferating cell nuclear antigen, Bcl-2, and Bax in lymphocytes of patients with oral lichen planus]. 54 61
19460716 2009
3
Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia. 61 54
19325208 2009
4
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. 61 54
18642282 2008
5
No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus. 61 54
18211414 2008
6
Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus. 61 54
17238971 2007
7
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus]. 54 61
17067460 2006
8
Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. 54 61
16476030 2006
9
Decreased expression of p63 in oral lichen planus and graft-vs.-host disease associated with oral inflammation. 61 54
16393253 2006
10
The feasibility of monitoring NF-kappaB associated cytokines: TNF-alpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. 61 54
16075467 2005
11
A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. 54 61
15721838 2005
12
Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. 61 54
15564824 2004
13
Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus. 54 61
15089928 2004
14
Expression of heat shock protein (HSP70) in oral lichen planus and non-dysplastic oral leucoplakia. 61 54
15113309 2004
15
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]. 54 61
12930657 2003
16
Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism. 61 54
12819030 2003
17
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. 61 54
12558634 2003
18
Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration. 54 61
11903822 2002
19
Mast cell degranulation and the role of T cell RANTES in oral lichen planus. 61 54
11575876 2001
20
LFA-3 (CD58) mediates T-lymphocyte adhesion in chronic inflammatory infiltrates. 61 54
10564548 1999
21
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis. 61 54
10226943 1999
22
Immunohistochemical and serological comparison of idiopathic and hepatitis C virus-associated forms of oral lichen planus. 61 54
9708688 1998
23
Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. 54 61
9649139 1998
24
Apoptosis-associated markers in oral lichen planus. 61 54
9176791 1997
25
Expression of lymphocyte function-associated antigen 3 in oral lichen planus. 54 61
8705826 1995
26
VCAM-1 and ICAM-1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus. 61 54
7523663 1994
27
Anxiety and oral lichen planus. 61
32697012 2021
28
Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis. 61
31994293 2021
29
Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study. 61
32797677 2021
30
Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment. 61
32929623 2021
31
Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis. 61
33717234 2021
32
The expression of membrane-bound complement regulatory proteins CD46, CD55 and CD59 in oral lichen planus. 61
33529836 2021
33
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions. 61
33550012 2021
34
Association between oral lichen planus and systemic conditions and medications: Case-control study. 61
32750751 2021
35
Malignant transformation of oral potentially malignant disorders in Taiwan: An observational nationwide population database study. 61
33655959 2021
36
Photobiomodulation Therapy/Photodynamic Therapy Versus Steroid Therapy for Oral Lichen Planus: A Systematic Review and Meta-Analysis. 61
33601953 2021
37
COVID-19: a possible trigger for oral lichen planus? 61
33686658 2021
38
MicroRNA-122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression. 61
33656264 2021
39
Micronutrients Profile in Oral Lichen Planus: a Review Literature. 61
32533293 2021
40
Comment on "Malignant transformation evidences of Oral Lichen Planus: When the time is of the essence" by Zotti F et al (May 2020). 61
33183995 2021
41
High-level laser therapy versus scalpel surgery in the treatment of oral lichen planus: a randomized control trial. 61
33704569 2021
42
The presence of P. melaninogenica within tissue and preliminary study on its role in the pathogenesis of oral lichen planus. 61
33780104 2021
43
Preliminary evaluation of the utility of optical coherence tomography in detecting structural changes during photobiomodulation treatment in patients with atrophic-erosive oral lichen planus. 61
33727132 2021
44
Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. 61
33682925 2021
45
A novel comprehensive scoring system for oral lichen planus: A validity, diagnostic accuracy, and clinical sensitivity study. 61
33451971 2021
46
Oral lichen planus: a microbiologist point of view. 61
33751292 2021
47
Observer agreement in the diagnosis of oral lichen planus using the proposed criteria of the American Academy of Oral and Maxillofacial Pathology. 61
33730381 2021
48
Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria. 61
31981238 2021
49
Decreased recurrence of symptoms in oral lichen planus with intralesional injection of hyaluronic acid and triamcinolone. 61
33741218 2021
50
Optical diagnosis of oral lichen planus: A clinical study on the use of autofluorescence spectroscopy combined with multivariate analysis. 61
33310275 2021

Variations for Oral Lichen Planus

Expression for Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for Oral Lichen Planus

Pathways related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 VCAM1 TIMP2 MMP1 IL1A ICAM1 HSPA8
2
Show member pathways
13.27 VCAM1 MMP1 ICAM1 CXCR3 CCR5 CCL5
3
Show member pathways
13.27 TIMP2 IL1A CXCR3 CCR5 CCL5 CASP3
4
Show member pathways
13.12 TIMP2 IL1A CXCR3 CCR5 CCL5 CASP3
5
Show member pathways
13.12 VCAM1 MMP1 IL1A ICAM1 HSPA8 CCR5
6
Show member pathways
12.82 ICAM1 CCR5 CCL5 CASP3 BAX
7
Show member pathways
12.71 IL1A HSPA8 CCL5 CASP3 BAX
8
Show member pathways
12.68 IL1A ICAM1 HSPD1 HSPA8 HSPA4 CASP3
9
Show member pathways
12.61 VCAM1 TIMP2 MMP1 ICAM1 CASP3
10
Show member pathways
12.51 IL1A ICAM1 HSPA8 CD58 CCL5 CASP3
11
Show member pathways
12.27 VCAM1 MMP1 ICAM1 HSPD1 HSPA8 HSPA4
12
Show member pathways
12.13 IL1A HSPA8 CCR5 CASP3
13 12.09 IL1A HSPD1 CASP3 BAX
14
Show member pathways
12.08 IL1A CASP3 BAX
15 11.97 VCAM1 IL1A ICAM1
16
Show member pathways
11.91 TP63 CASP3 BAX
17 11.89 IL1A ICAM1 CASP3
18 11.83 VCAM1 ICAM1 CCL5 CASP3
19
Show member pathways
11.71 VCAM1 CASP3 BAX
20 11.7 MMP1 ICAM1 BAX
21 11.7 MMP1 IL1A ICAM1 CCL5
22 11.69 HSPD1 HSPA4 BAX
23 11.61 VCAM1 MMP1 IL1A ICAM1 HSPA8
24 11.5 HSPD1 HSPA8 CASP3
25
Show member pathways
11.47 VCAM1 MMP1 IL1A ICAM1
26 11.36 MMP1 CASP3 BAX
27 11.35 VCAM1 IL1A ICAM1 CASP3 BAX
28 11.31 IL1A ICAM1 CCR5 CCL5
29 11.26 TIMP2 MMP1 CCL5
30
Show member pathways
11 TP63 BAX
31 10.87 MMP1 CCL5
32 10.83 VCAM1 ICAM1

GO Terms for Oral Lichen Planus

Cellular components related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 VCAM1 TIMP2 IL1A ICAM1 HSPD1 HSPA8
2 external side of plasma membrane GO:0009897 9.46 VCAM1 ICAM1 CXCR3 CCR5
3 cell surface GO:0009986 9.17 VCAM1 TIMP2 ICAM1 HSPD1 CXCR3 CD58

Biological processes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10 TP63 IL1A CXCR3 CASP3 BAX
2 inflammatory response GO:0006954 9.94 IL1A CXCR3 CCR5 CCL5
3 response to drug GO:0042493 9.88 TIMP2 ICAM1 HSPD1 CASP3
4 response to organic cyclic compound GO:0014070 9.8 ICAM1 HSPD1 CASP3
5 response to hypoxia GO:0001666 9.8 VCAM1 ICAM1 HSPD1 CASP3
6 response to lipopolysaccharide GO:0032496 9.78 VCAM1 ICAM1 HSPD1 CASP3
7 cellular response to interferon-gamma GO:0071346 9.77 ICAM1 CD58 CCL5
8 response to organic substance GO:0010033 9.74 TIMP2 HSPD1 CASP3
9 chemokine-mediated signaling pathway GO:0070098 9.73 CXCR3 CCR5 CCL5
10 response to unfolded protein GO:0006986 9.72 HSPD1 HSPA8 HSPA4
11 cellular response to tumor necrosis factor GO:0071356 9.71 VCAM1 ICAM1 CD58 CCL5
12 response to ionizing radiation GO:0010212 9.69 VCAM1 ICAM1 BAX
13 B cell homeostasis GO:0001782 9.64 CASP3 BAX
14 chaperone-mediated protein complex assembly GO:0051131 9.63 HSPD1 HSPA4
15 protein refolding GO:0042026 9.63 HSPD1 HSPA8
16 viral process GO:0016032 9.63 MMP1 ICAM1 HSPD1 HSPA8 CCR5 BAX
17 apoptotic mitochondrial changes GO:0008637 9.62 HSPD1 BAX
18 dendritic cell chemotaxis GO:0002407 9.61 CCR5 CCL5
19 response to copper ion GO:0046688 9.61 IL1A ICAM1
20 neuron apoptotic process GO:0051402 9.61 TP63 CASP3 BAX
21 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.58 TP63 BAX
22 ectopic germ cell programmed cell death GO:0035234 9.54 IL1A BAX
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.54 IL1A CASP3 BAX
24 membrane to membrane docking GO:0022614 9.52 VCAM1 ICAM1
25 cellular response to organic substance GO:0071310 9.5 ICAM1 CASP3 BAX
26 adhesion of symbiont to host GO:0044406 9.46 ICAM1 HSPD1
27 leukocyte cell-cell adhesion GO:0007159 9.43 VCAM1 ICAM1 CCL5
28 cell chemotaxis GO:0060326 9.26 VCAM1 CXCR3 CCR5 CCL5
29 cytokine-mediated signaling pathway GO:0019221 9.23 VCAM1 MMP1 IL1A ICAM1 HSPA8 CCR5

Molecular functions related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.43 VCAM1 TIMP2 ICAM1
2 chemokine receptor activity GO:0004950 9.16 CXCR3 CCR5
3 protease binding GO:0002020 9.13 TIMP2 HSPD1 CASP3
4 chaperone binding GO:0051087 8.8 HSPD1 HSPA8 BAX

Sources for Oral Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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