MCID: ORL013
MIFTS: 45

Oral Lichen Planus

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Oral Lichen Planus

MalaCards integrated aliases for Oral Lichen Planus:

Name: Oral Lichen Planus 52 17
Oral Lichenoid Lesions 52
Lichen Planus, Oral 71
Lichen Planus Oral 54

Classifications:



External Ids:

UMLS 71 C0206139

Summaries for Oral Lichen Planus

NIH Rare Diseases : 52 Oral lichen planus is a inflammatory condition that affects the inside of the mouth. Signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. Most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. Severe lichen planus slightly increases the risk for oral cancer . Oral lichen planus may occur alone or in combination with other skin forms of lichen planus.

MalaCards based summary : Oral Lichen Planus, also known as oral lichenoid lesions, is related to lichen planus and gingivitis, and has symptoms including oral manifestations An important gene associated with Oral Lichen Planus is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, tongue and skin, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and cardiovascular system

Related Diseases for Oral Lichen Planus

Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 lichen planus 32.9 ICAM1 CXCR3 CCL5
2 gingivitis 31.0 MMP1 IL1A ICAM1 CCL5
3 oral cancer 31.0 MMP1 CASP3 BAX
4 periodontitis 31.0 MMP1 IL1A ICAM1
5 allergic hypersensitivity disease 31.0 VCAM1 ICAM1 CCL5
6 contact dermatitis 30.8 IL1A ICAM1 CXCR3
7 proteasome-associated autoinflammatory syndrome 1 30.6 VCAM1 IL1A ICAM1 CCL5
8 alopecia areata 30.4 IL1A ICAM1 CXCR3
9 keratoconjunctivitis 30.3 MMP1 ICAM1 CCL5
10 vasculitis 30.2 VCAM1 ICAM1 HSPD1
11 graves' disease 30.0 IL1A ICAM1 CXCR3 CCL5
12 autoimmune disease 30.0 VCAM1 IL1A HSPD1 CXCR3 CD58 CCR5
13 dermatitis, atopic 30.0 VCAM1 IL1A ICAM1 CXCR3 CCL5
14 viral infectious disease 30.0 ICAM1 CXCR3 CCR5 CCL5
15 primary biliary cirrhosis 29.8 ICAM1 HSPD1 CXCR3 CD58
16 diabetes mellitus, type i 29.6 VCAM1 ICAM1 HSPD1 CCR5
17 skin disease 29.5 TP63 MMP1 IL1A ICAM1 HSPA4 CXCR3
18 psoriatic arthritis 29.5 MMP1 IL1A CD58
19 diabetes mellitus 29.4 VCAM1 IL1A ICAM1 HSPD1 HSPA4 CCR5
20 ischemia 29.2 ICAM1 HSPD1 HSPA8 HSPA4 CASP3
21 sarcoidosis 1 29.1 IL1A ICAM1 HSPA4 CXCR3 CCR5 CCL5
22 psoriasis 29.1 VCAM1 IL1A ICAM1 CXCR3 CD58 CCL5
23 systemic lupus erythematosus 28.9 VCAM1 IL1A ICAM1 HSPD1 CXCR3 CCR5
24 inflammatory bowel disease 28.4 VCAM1 MMP1 IL1A ICAM1 HSPD1 HSPA4
25 rheumatoid arthritis 28.1 VCAM1 TIMP2 MMP1 IL1A ICAM1 HSPD1
26 oral squamous cell carcinoma 11.0
27 hepatitis c 10.9
28 squamous cell carcinoma 10.9
29 hepatitis c virus 10.9
30 leukoplakia 10.9
31 candidiasis 10.7
32 keratosis 10.7
33 oral leukoplakia 10.7
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.7
35 mucositis 10.6
36 hypothyroidism 10.6
37 stomatitis 10.6
38 liver disease 10.6
39 bullous pemphigoid 10.6
40 oral candidiasis 10.6
41 pemphigus 10.6
42 graft-versus-host disease 10.6
43 burning mouth syndrome 10.5
44 cytokine deficiency 10.5
45 ocular cicatricial pemphigoid 10.5
46 pemphigus vulgaris, familial 10.5
47 anxiety 10.5
48 squamous cell papilloma 10.5
49 hepatitis 10.5
50 papilloma 10.5

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to Oral Lichen Planus

Symptoms & Phenotypes for Oral Lichen Planus

UMLS symptoms related to Oral Lichen Planus:


oral manifestations

GenomeRNAi Phenotypes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.8 CD58 HSPD1 IL1A

MGI Mouse Phenotypes related to Oral Lichen Planus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CASP3 CCR5 CXCR3 HSPD1 ICAM1 IL1A
2 hematopoietic system MP:0005397 9.85 BAX CASP3 CCL5 CCR5 CXCR3 HSPD1
3 immune system MP:0005387 9.7 BAX CASP3 CCL5 CCR5 CXCR3 ICAM1
4 neoplasm MP:0002006 9.17 BAX CCR5 CXCR3 ICAM1 IL1A MMP1

Drugs & Therapeutics for Oral Lichen Planus

Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
5 Lycopene Approved, Investigational Phase 4 502-65-8 53477748
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
11
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
12
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
13
Zinc Approved, Investigational Phase 4 7440-66-6 32051
14
Pomegranate Experimental, Investigational Phase 4
15
Chitosan Experimental Phase 4 9012-76-4 71853
16
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
17 Hormones Phase 4
18 Hormone Antagonists Phase 4
19 glucocorticoids Phase 4
20 Respiratory System Agents Phase 4
21 Anti-Asthmatic Agents Phase 4
22 Antifungal Agents Phase 4
23 Betamethasone sodium phosphate Phase 4
24 Betamethasone benzoate Phase 4
25 Betamethasone Valerate Phase 4 2152-44-5
26 Betamethasone-17,21-dipropionate Phase 4
27 Antineoplastic Agents, Hormonal Phase 4
28 Protective Agents Phase 4
29 Radiation-Protective Agents Phase 4
30 Methylprednisolone Acetate Phase 4
31 Chlorhexidine gluconate Phase 4
32
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
33
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
34
Clobetasol Approved, Experimental, Investigational Phase 2, Phase 3 25122-41-2, 25122-46-7 32798 5311051
35
Nystatin Approved, Vet_approved Phase 2, Phase 3 1400-61-9 11953884
36
Petrolatum Approved, Investigational Phase 3 8009-03-8
37
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
38 Tea Phase 3
39 Cyclooxygenase Inhibitors Phase 2, Phase 3
40 Anti-Infective Agents Phase 3
41 Anti-Bacterial Agents Phase 3
42 Antibiotics, Antitubercular Phase 3
43
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
44
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
45
Fluconazole Approved, Investigational Phase 1, Phase 2 86386-73-4 3365
46
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
47
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
48
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
49
Metronidazole Approved Phase 2 443-48-1 4173
50
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial) Completed NCT04193748 Phase 4 Topical pomegranate seeds and peel extracts
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus: A Pilot, Randomized, Clinical and Immunohistochemical Trial Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus: A Randomized, Double Blind Clinical Trial Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 A Comparative Clinical and Immunohistochemical Study Between Topical Pimecrolimus and Corticosteroid in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 Management of Pain in Oral Lichen Planus Patients: A Comparative Pilot Study Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
6 Comparative Evaluation of Effect of Oral Zinc Supplementation and Placebo as an Adjuvant to Topical Corticosteroid Therapy in Oral Lichen Planus Patients Recruiting NCT04278599 Phase 4 Oral Zinc supplementation;Oral placebo supplementation
7 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
8 Randomized Placebo-Controlled Clinical Pilot Trial Regarding the Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
9 Evaluation of Systemic Administration of Green Tea Polyphenols as a Supportive Antioxidant Agent in the Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
10 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treatment Oral LichenPlanus Completed NCT02421770 Phase 3
11 Use of Topical Non-Steroidal Anti- Inflammatory to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Completed NCT03509675 Phase 2, Phase 3 Ibuprofen suspension 5mg/100ml;Placebos
12 Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus. A Multicenter Placebo-controlled Randomized Clinical Trial. Not yet recruiting NCT04364555 Phase 2, Phase 3 Clobetasol Propionate;Placebo/active;Placebo/placebo
13 Efficacy of Topical Rapamycin in Treatment of Chronic Erosive Oral Lichen Planus. Double Blind Randomised Controlled Trial Rapamycin vs Topical Steroids Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
14 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
15 A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus Unknown status NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
16 Efficacy of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids on Pain Relief and Ulcers Healing in Patients With Erosive Oral Lichen Planus; Randomized Clinical Trial Unknown status NCT03293368 Phase 2 Triamcinolone Acetonide
17 Dexamethasone Solution and Dexamethasone in Mucolox™ for the Treatment of Oral Lichen Planus Unknown status NCT02850601 Phase 2 Dexamethasone
18 Cedar Honey in Treatment of Oral Lichen Planus: a Randomized Clinical Trial Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
19 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
20 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus- A Double-blinded Randomized Clinical Trial in Sri Lanka Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
21 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus and Improvement of Quality of Life: A Randomized, Double Blind, Controlled Study Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
22 A 6-week Randomized, Double-blind, Vehicle-controlled Pilot Study With a 6-week Open Label Extension to Assess the Efficacy and Safety of Pimecrolimus 1% Cream in the Treatment of Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
23 A Randomized, Placebo-Controlled, Double-Blind Trial of a Two Week Course of Curcuminoids in Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
24 Efficacy of Oral Lycopene in the Management of Oral Lichen Planus Completed NCT00656214 Phase 2 Lycopene;Placebo
25 Treatment of Oral Lichen Planus Lesions Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
26 Effect of the Probiotic Bifidobacterium Animalis Subsp. Lactis HN019 on Clinical, Histopathological and Immunophenotypic Features of Oral Lichen Planus Completed NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
27 Hydroxychloroquine Versus Clobetasol 0.05% Rinse for the Treatment of Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
28 Dexamethasone 0.01% Solution for the Treatment of Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
29 Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
30 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on the Duration and Symptoms of Lesions That Caused by Symptomatic Oral Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
31 A Single Center, Investigator-blinded Study of the Efficacy of Topical Cyclosporine 0.05% Ophthalmic Suspension (RESTASIS®) Under Occlusion Versus Vehicle in the Treatment of Brittle Nail Syndrome Completed NCT01064830 Phase 2 topical cyclosporine ophthalmic suspension 0.05%;vehicle
32 The APOLP Trial: A Single-Center, Randomized, 16 Weeks, Explanatory, Parallel-Group, Superiority, Blinded, Placebo-Controlled, Clinical Trial of Apremilast Use in Oral Lichen Planus Recruiting NCT03836885 Phase 2 Apremilast;Placebo
33 A Randomized, Double-blind, Placebo-controlled, Parallel Group Clinical Study to Assess the Safety and Efficacy of Three Doses of Clobetasol Propionate When Administered Intra-orally Twice Daily in Patients With Oral Lichen Planus (OLP) Using Rivelin®-CLO Patches Recruiting NCT03592342 Phase 2 Clobetasol Propionate
34 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
35 Phase 2 Study of the Treatment of Oral Erosive Lichen Planus With 1% Pimecrolimus Cream: a Double Blind Randomized Prospective Trial With Measurement of Pimecrolimus Levels in the Blood Terminated NCT00321750 Phase 2 1% pimecrolimus cream
36 A Double-Blind, Randomized, Multicenter Pilot Study to Evaluate the Efficacy and Safety of Etanercept 50mg SC Twice Weekly in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo
37 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
38 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
39 Evaluation of Salivary Total Oxidant Capacity in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid Supplemented With Vitamin E Versus Topical Corticosteroid Alone Completed NCT04126720 Phase 1 Topical corticosteroid and placebo capsules
40 The Effect of Topical Curcumin Versus Topical Corticosteroid on Pain, Clinical Parameters and Salivary Level of IL-33 in Oral Lichen Planus Patients: A Randomized Controlled Clinical Trial Not yet recruiting NCT03877679 Phase 1 Triamcinolone;Turmeric paste
41 Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus Not yet recruiting NCT03793634 Phase 1 topical chamomile
42 11 El-Saraya St. - Manial - Cairo Not yet recruiting NCT04091698 Phase 1 Co-Enzyme Q10 mucoadhesive tablets
43 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573
44 Based on Metabonomics Dryness Pathogen Type of Oral Lichen Planus of Dynamic Unknown status NCT02332486 Qingxuan Decoction
45 Efficacy of 200mg and 300mg Concentrates of Green Tea Polyphenols Using Buccal Tablets Versus Topical Application of Corticosteroids in Treatment of Patients With Symptomic Oral Lichen Planus Randomized Clinical Trial Unknown status NCT03415165 Early Phase 1 green tea buccal tablet;Corticosteroids Topical
46 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus. Diagnostic Value of White Light Endoscopy, Narrow Band Imaging and Chromoendoscopy for Detection of Esophageal Manifestation in Patients With Oral Lichen. Unknown status NCT02532166
47 Comparative Efficacy of Dexamethasone, Doxycycline, Nystatin and Promethazine With Triamcinolone in Orabase as Symptomatic Treatment of Oral Lichen Planus, A Randomized Controlled Trial Unknown status NCT03237533 Early Phase 1 Dexamethasone
48 Randomized Controlled Study of Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662 Ribavirin;Betamethasone
49 To Evaluate the Efficacy of Aloe Vera Gel in Gingival Massaging and as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis Unknown status NCT03083535
50 A Single Center, Open-label, Pilot Study Evaluating the Safety and Effectiveness of Subcutaneous Efalizumab in the Treatment of Oral Lichen Planus Completed NCT00133107 efalizumab

Search NIH Clinical Center for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

MalaCards organs/tissues related to Oral Lichen Planus:

40
T Cells, Tongue, Skin, Thyroid, Liver, Testes, Endothelial

Publications for Oral Lichen Planus

Articles related to Oral Lichen Planus:

(show top 50) (show all 2692)
# Title Authors PMID Year
1
Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma. 54 61
19751907 2009
2
[Expressions of proliferating cell nuclear antigen, Bcl-2, and Bax in lymphocytes of patients with oral lichen planus]. 54 61
19460716 2009
3
Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia. 61 54
19325208 2009
4
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. 61 54
18642282 2008
5
No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus. 61 54
18211414 2008
6
Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus. 61 54
17238971 2007
7
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus]. 61 54
17067460 2006
8
Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. 61 54
16476030 2006
9
Decreased expression of p63 in oral lichen planus and graft-vs.-host disease associated with oral inflammation. 61 54
16393253 2006
10
The feasibility of monitoring NF-kappaB associated cytokines: TNF-alpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. 61 54
16075467 2005
11
A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. 54 61
15721838 2005
12
Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. 54 61
15564824 2004
13
Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus. 61 54
15089928 2004
14
Expression of heat shock protein (HSP70) in oral lichen planus and non-dysplastic oral leucoplakia. 54 61
15113309 2004
15
Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism. 54 61
12819030 2003
16
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]. 54 61
12930657 2003
17
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. 61 54
12558634 2003
18
Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration. 54 61
11903822 2002
19
Mast cell degranulation and the role of T cell RANTES in oral lichen planus. 61 54
11575876 2001
20
LFA-3 (CD58) mediates T-lymphocyte adhesion in chronic inflammatory infiltrates. 61 54
10564548 1999
21
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis. 61 54
10226943 1999
22
Immunohistochemical and serological comparison of idiopathic and hepatitis C virus-associated forms of oral lichen planus. 54 61
9708688 1998
23
Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. 61 54
9649139 1998
24
Apoptosis-associated markers in oral lichen planus. 61 54
9176791 1997
25
Expression of lymphocyte function-associated antigen 3 in oral lichen planus. 61 54
8705826 1995
26
VCAM-1 and ICAM-1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus. 61 54
7523663 1994
27
Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action. 61
32371143 2020
28
Clinicopathological and prognostic characteristics of oral squamous cell carcinomas arising in patients with oral lichen planus: A systematic review and a comprehensive meta-analysis. 61
32305649 2020
29
A case report of oral lichenoid lesions. Are patch tests necessary? 61
32189343 2020
30
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus. 61
32205175 2020
31
Application of a non-invasive oral brushing procedure based on bisulfite sequencing of a 13-gene panel to study high-risk OSCC patients. 61
32568174 2020
32
Salivary β2-microglobulin levels in patients with erosive oral lichen planus and squamous cell carcinoma. 61
32552881 2020
33
[Pathogenicity and drug-resistance analysis of Candida glabrata in patients with oral candidiasis]. 61
32536122 2020
34
Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment. 61
32506228 2020
35
Study on the Role of Salivary Flora and NF-κB Inflammatory Signal Pathway in Oral Lichen Planus. 61
32016629 2020
36
Dexamethasone solution and dexamethasone in Mucolox for the treatment of oral lichen planus: a preliminary study. 61
32220595 2020
37
Could photodynamic therapy be utilized as a treatment modality for oral lichen planus? 61
32006650 2020
38
Oral Lichen Planus - Related Connection with HLA-System Antigens. 61
32573477 2020
39
Micronutrients Profile in Oral Lichen Planus: a Review Literature. 61
32533293 2020
40
Oral Lichen Planus Pemphigoides: Three Cases of a Rare Entity. 61
31809271 2020
41
Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders. 61
32378537 2020
42
Clinicopathological and prognostic characterization of oral lichenoid disease and its main subtypes: A series of 384 cases. 61
32388519 2020
43
Evaluation of synuclein-γ levels by novel monoclonal antibody in saliva and cancer tissues from oral squamous cell carcinoma patients. 61
32202903 2020
44
Clinical and pathological characterization of oral mucosal 'lichen planus-like lesions' in patients with pemphigus vulgaris: An observational study. 61
31031312 2020
45
Is oral lichen planus a risk factor for peri-implant diseases? A systematic review and meta-analysis. 61
32434508 2020
46
Oral lichen planus: a chronic inflammatory model to study the regulation of the Toll-like receptor signaling in oral keratinocytes. 61
32470550 2020
47
Oral bacterial diversity is inversely correlated with mucosal inflammation. 61
32419230 2020
48
Urinary metabolomic signatures in reticular oral lichen planus. 61
32490246 2020
49
Predictors of symptomatic oral lichen planus. 61
32044267 2020
50
Malignant transformation evidences of Oral Lichen Planus: When the time is of the essence. 61
32067905 2020

Variations for Oral Lichen Planus

Expression for Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for Oral Lichen Planus

Pathways related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 VCAM1 TIMP2 MMP1 IL1A ICAM1 HSPA8
2
Show member pathways
13.27 VCAM1 MMP1 ICAM1 CXCR3 CCR5 CCL5
3
Show member pathways
13.27 TIMP2 IL1A CXCR3 CCR5 CCL5 CASP3
4
Show member pathways
13.12 TIMP2 IL1A CXCR3 CCR5 CCL5 CASP3
5
Show member pathways
13.08 VCAM1 MMP1 IL1A ICAM1 HSPA8 CCR5
6
Show member pathways
12.81 ICAM1 CCR5 CCL5 CASP3 BAX
7
Show member pathways
12.65 IL1A ICAM1 HSPD1 HSPA8 HSPA4 CASP3
8
Show member pathways
12.61 VCAM1 TIMP2 MMP1 ICAM1 CASP3
9
Show member pathways
12.41 IL1A ICAM1 HSPA8 CD58 CCL5 CASP3
10
Show member pathways
12.13 IL1A HSPA8 CCR5 CASP3
11 12.09 IL1A HSPD1 CASP3 BAX
12
Show member pathways
12.08 IL1A CASP3 BAX
13 11.97 VCAM1 IL1A ICAM1
14
Show member pathways
11.91 TP63 CASP3 BAX
15 11.88 IL1A ICAM1 CASP3
16 11.81 VCAM1 ICAM1 CCL5 CASP3
17
Show member pathways
11.7 VCAM1 CASP3 BAX
18 11.69 MMP1 ICAM1 BAX
19 11.68 HSPD1 HSPA4 BAX
20 11.67 MMP1 IL1A ICAM1 CCL5
21 11.5 HSPD1 HSPA8 CASP3
22
Show member pathways
11.42 VCAM1 MMP1 IL1A ICAM1
23 11.41 VCAM1 MMP1 IL1A ICAM1 HSPA8
24 11.36 MMP1 CASP3 BAX
25 11.26 TIMP2 MMP1 CCL5
26 11.25 IL1A ICAM1 CCR5 CCL5
27 11.2 IL1A CCL5 BAX
28 11.02 VCAM1 IL1A ICAM1 CASP3 BAX
29
Show member pathways
10.99 TP63 BAX
30 10.86 MMP1 CCL5
31 10.83 VCAM1 ICAM1

GO Terms for Oral Lichen Planus

Cellular components related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 VCAM1 TIMP2 IL1A ICAM1 HSPD1 HSPA8
2 external side of plasma membrane GO:0009897 9.46 VCAM1 ICAM1 CXCR3 CCR5
3 cell surface GO:0009986 9.17 VCAM1 TIMP2 ICAM1 HSPD1 CXCR3 CD58

Biological processes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.96 TP63 IL1A CXCR3 CASP3 BAX
2 inflammatory response GO:0006954 9.9 IL1A CXCR3 CCR5 CCL5
3 cellular response to tumor necrosis factor GO:0071356 9.77 ICAM1 CD58 CCL5
4 cellular response to interferon-gamma GO:0071346 9.71 ICAM1 CD58 CCL5
5 cell chemotaxis GO:0060326 9.7 CXCR3 CCR5 CCL5
6 response to unfolded protein GO:0006986 9.69 HSPD1 HSPA8 HSPA4
7 chemokine-mediated signaling pathway GO:0070098 9.67 CXCR3 CCR5 CCL5
8 B cell homeostasis GO:0001782 9.61 CASP3 BAX
9 chaperone-mediated protein complex assembly GO:0051131 9.61 HSPD1 HSPA4
10 apoptotic mitochondrial changes GO:0008637 9.58 HSPD1 BAX
11 dendritic cell chemotaxis GO:0002407 9.58 CCR5 CCL5
12 response to copper ion GO:0046688 9.57 IL1A ICAM1
13 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.55 TP63 BAX
14 neuron apoptotic process GO:0051402 9.54 TP63 CASP3 BAX
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.5 IL1A CASP3 BAX
16 ectopic germ cell programmed cell death GO:0035234 9.48 IL1A BAX
17 negative regulation of macrophage apoptotic process GO:2000110 9.46 CCR5 CCL5
18 membrane to membrane docking GO:0022614 9.43 VCAM1 ICAM1
19 cellular response to organic substance GO:0071310 9.43 ICAM1 CASP3 BAX
20 viral process GO:0016032 9.43 MMP1 ICAM1 HSPD1 HSPA8 CCR5 BAX
21 adhesion of symbiont to host GO:0044406 9.4 ICAM1 HSPD1
22 leukocyte cell-cell adhesion GO:0007159 9.33 VCAM1 ICAM1 CCL5
23 cytokine-mediated signaling pathway GO:0019221 9.23 VCAM1 MMP1 IL1A ICAM1 HSPA8 CCR5

Molecular functions related to Oral Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.43 VCAM1 TIMP2 ICAM1
2 chemokine receptor activity GO:0004950 9.16 CXCR3 CCR5
3 protease binding GO:0002020 9.13 TIMP2 HSPD1 CASP3
4 chaperone binding GO:0051087 8.8 HSPD1 HSPA8 BAX

Sources for Oral Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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