MCID: ORL006
MIFTS: 20

Oral Mucosa Leukoplakia

Categories: Oral diseases
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Aliases & Classifications for Oral Mucosa Leukoplakia

MalaCards integrated aliases for Oral Mucosa Leukoplakia:

Name: Oral Mucosa Leukoplakia 11 14
Leukoplakia of Buccal Mucosa 71
Leukoplakia, Oral 71

Classifications:



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Disease Ontology 11 DOID:9655
ICD9CM 34 528.6
UMLS 71 C0023532 C0399470 C1112530

Summaries for Oral Mucosa Leukoplakia

Disease Ontology: 11 A mouth disease that is characterized by a white patch or plaque that develops in the oral cavity and is strongly associated with smoking.

MalaCards based summary: Oral Mucosa Leukoplakia, also known as leukoplakia of buccal mucosa, is related to leukoplakia and lichen planus. An important gene associated with Oral Mucosa Leukoplakia is TEC (Tec Protein Tyrosine Kinase). The drugs Rosiglitazone and Celecoxib have been mentioned in the context of this disorder.

Related Diseases for Oral Mucosa Leukoplakia

Diseases related to Oral Mucosa Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukoplakia 10.2
2 lichen planus 10.0
3 oral leukoplakia 10.0
4 tongue carcinoma 9.6 TECR MAU2

Symptoms & Phenotypes for Oral Mucosa Leukoplakia

Drugs & Therapeutics for Oral Mucosa Leukoplakia

Drugs for Oral Mucosa Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4, 155141-29-0 77999
2
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
3
Pembrolizumab Approved Phase 2 1374853-91-4 254741536
4
Nivolumab Approved Phase 2 946414-94-4
5
Metformin Approved Phase 2 1115-70-4, 657-24-9 4091
6
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
7
Maleic acid Experimental, Investigational Phase 2 110-16-7, 110-17-8 444266 444972
8 Antirheumatic Agents Phase 2
9 Cyclooxygenase Inhibitors Phase 2
10 Cyclooxygenase 2 Inhibitors Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Analgesics, Non-Narcotic Phase 2
14 Analgesics Phase 2
15 Immune Checkpoint Inhibitors Phase 2
16 Antineoplastic Agents, Immunological Phase 2
17 Hypoglycemic Agents Phase 2
18 Tea Phase 2
19
Aminolevulinic acid Approved Phase 1 106-60-5 137
20 Photosensitizing Agents Phase 1
21 Dermatologic Agents Phase 1
22
Nitrous oxide Approved, Vet_approved 10024-97-2 948
23
Nitric Oxide Approved 10102-43-9 145068
24
Fluconazole Approved, Investigational 86386-73-4 3365
25
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
26
Clotrimazole Approved, Vet_approved 23593-75-1 2812
27
Heparin, bovine Approved, Investigational, Withdrawn 9005-49-6 22833565 9812414 772
28
Sulindac Approved, Investigational 38194-50-2 5352 1548887
29
Ethanol Approved 64-17-5 702
30
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
31 Antioxidants
32 Protective Agents
33 Hormones
34 Anti-Infective Agents
35 Hormone Antagonists
36 Antifungal Agents
37 Cytochrome P-450 Enzyme Inhibitors
38 Calcium heparin
39 Hemostatics
40 Coagulants
41
Tolonium Chloride
42 Anesthetics

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia Completed NCT00155337 Phase 4
2 Phase IIA Trial of Rosiglitazone (Avandia) for Oral Leukoplakia Completed NCT00369174 Phase 2 rosiglitazone maleate
3 A Phase IIb Cancer Prevention Trial of Celecoxib, a Selective COX-2 Inhibitor, in Oral Leukoplakia Completed NCT00101335 Phase 2 celecoxib
4 A Phase IIa Cancer Prevention Trial of the PPAR Gamma Agonist Pioglitazone in Oral Leukoplakia Completed NCT00099021 Phase 2 pioglitazone hydrochloride
5 Bowman Birk Inhibitor Concentrate and Oral Leukoplakia: A Randomized Phase IIb Trial Completed NCT00330382 Phase 2 Bowman-Birk inhibitor concentrate
6 A Phase II Open Label, Single Arm Study to Evaluate the Efficacy of Pembrolizumab for Leukoplakia Recruiting NCT03603223 Phase 2
7 Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia Active, not recruiting NCT03692325 Phase 2 Nivolumab
8 M4OC-Prevent: Metformin for Oral Cancer Prevention Active, not recruiting NCT02581137 Phase 2 Metformin Hydrochloride
9 M4OC-Prevent 2.0: Phase IIb Trial of Metformin for Oral Cancer Prevention Not yet recruiting NCT05237960 Phase 2 Extended Release Metformin Hydrochloride;Placebo Administration
10 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
11 Phase IIB Randomized, Placebo Controlled Trial of Pioglitazone for Oral Premalignant Lesions an Inter-consortium Collaborative Study Terminated NCT00951379 Phase 2 Pioglitazone hydrochloride
12 Phase I Study of Photodynamic Therapy Using Pulsed Dye Laser and Oral Aminolevulinic Acid in Patients With Oral Leukoplakia Terminated NCT00571558 Phase 1 aminolevulinic acid hydrochloride;photodynamic therapy
13 A Phase 1, Randomized, Double-blind, Placebo Controlled, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of SBS-101 After Intraoral Application in Patients With Oral Premalignant Lesions (OPL) Withdrawn NCT03939364 Phase 1 SBS-101;Placebo
14 Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia: a Pilot Study Withdrawn NCT05505539 Phase 1 5-fluorouracil
15 Dental Hygienists and Oral Mucosal Inspection - Extent, Knowledge and Perceived Barriers Unknown status NCT04079491
16 Least Invasive Nonlinear Light Microscopy Unknown status NCT00767442
17 Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study Unknown status NCT04251845
18 Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions Completed NCT04267419
19 Association of Candida and Antifungal Therapy With Pro-inflammatory Cytokines in Oral Leukoplakia- A Pilot Study Completed NCT04712929
20 Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions Completed NCT03682562
21 Development of an Oral Epithelial Dysplasia Informational Needs Questionnaire Completed NCT04153266
22 Efficacy of Rose Bengal in Comparison With Toluidine Blue in Detection of Premalignant Lesions: a Preliminary Study Completed NCT03031899
23 A Pilot Multi-Center International Double-Blind Placebo Controlled Randomized Study of Sulindac, a Pan-Cox Inhibitor, in Oral Premalignant Lesions Completed NCT00299195 sulindac;Placebo
24 Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia Completed NCT03233165
25 Clinical Evaluation of the OncAlert RAPID; Impact on Decision-Making Completed NCT03239834
26 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Completed NCT01636544
27 Comparison Between Surgical Excision and "Wait and See" Approach in the Treatment of Oral Leukoplakia: a Randomized, Controlled Clinical Trial Recruiting NCT04858100
28 Prospective Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore Recruiting NCT03975322
29 Fluorescence &Amp; Reflectance Imaging to Detect Oral Neoplasia Active, not recruiting NCT00542373
30 Biomarkers for Oral Cancer Active, not recruiting NCT00341497
31 THE HONG KONG ORAL CANCER EDUCATION AND SCREENING (HOCES) PROGRAM: REFINING DISEASE PREVENTION, RISK STRATIFICATION AND EARLY DETECTION Not yet recruiting NCT04487938
32 Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions Not yet recruiting NCT04732741

Search NIH Clinical Center for Oral Mucosa Leukoplakia

Genetic Tests for Oral Mucosa Leukoplakia

Anatomical Context for Oral Mucosa Leukoplakia

Publications for Oral Mucosa Leukoplakia

Articles related to Oral Mucosa Leukoplakia:

(show all 16)
# Title Authors PMID Year
1
[Oral leukoplakia associated with Human Papilloma Virus; a bipolar infection in a young patient]. 62
33351365 2020
2
Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. 62
30884918 2019
3
Evaluating the Role of Immunological Cells (Tissue Eosinophils and Mast Cells) in Progression of Oral Squamous Cell Carcinoma. 62
29769506 2018
4
[Diagnostic value of optical coherence tomography for oral leukoplakia assessment]. 62
29465074 2018
5
[Leukoplakia: clinical and pathological diagnosis]. 62
36475409 2017
6
Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma. 62
27656549 2016
7
Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma. 62
26457223 2015
8
[Studies on tea and health]. 62
22279681 2011
9
Actual proliferating index in oral squamous cell carcinoma and leukoplakia. 62
25426788 2011
10
Multimodality approach to optical early detection and  mapping of oral neoplasia. 62
21806268 2011
11
Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia. 62
20070484 2010
12
[A white lesion of the oral mucosa: leukoplakia?]. 62
14640054 2003
13
[Incidence of diabetes mellitus in patients with malignant tumors of the oral cavity]. 62
12587541 2002
14
The chemopreventive effects of tea on human oral precancerous mucosa lesions. 62
10202392 1999
15
[Dental caries, periodontal diseases and the condition of mouth mucosa in workers of the petrochemical industry]. 62
6645941 1983
16
[Cryotherapy in the treatment of oral mucosa leukoplakia]. 62
1067928 1976

Variations for Oral Mucosa Leukoplakia

Expression for Oral Mucosa Leukoplakia

Search GEO for disease gene expression data for Oral Mucosa Leukoplakia.

Pathways for Oral Mucosa Leukoplakia

GO Terms for Oral Mucosa Leukoplakia

Sources for Oral Mucosa Leukoplakia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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