Oral Mucosa Leukoplakia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ORL006 MIFTS: 20	Oral Mucosa Leukoplakia Categories: Oral diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Oral Mucosa Leukoplakia

MalaCards integrated aliases for Oral Mucosa Leukoplakia:

Name: Oral Mucosa Leukoplakia ¹¹ ¹⁴

Leukoplakia of Buccal Mucosa ⁷¹

Leukoplakia, Oral ⁷¹

Classifications:

MalaCards categories:
Anatomical: Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:9655

ICD9CM ³⁴ 528.6

UMLS ⁷¹ C0023532 C0399470 C1112530

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Summaries for Oral Mucosa Leukoplakia

Disease Ontology: ¹¹ A mouth disease that is characterized by a white patch or plaque that develops in the oral cavity and is strongly associated with smoking.

MalaCards based summary: Oral Mucosa Leukoplakia, also known as leukoplakia of buccal mucosa, is related to leukoplakia and lichen planus. An important gene associated with Oral Mucosa Leukoplakia is TEC (Tec Protein Tyrosine Kinase). The drugs Rosiglitazone and Celecoxib have been mentioned in the context of this disorder.

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Related Diseases for Oral Mucosa Leukoplakia

Diseases related to Oral Mucosa Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	leukoplakia	10.2
2	lichen planus	10.0
3	oral leukoplakia	10.0
4	tongue carcinoma	9.6	TECR MAU2

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Symptoms & Phenotypes for Oral Mucosa Leukoplakia

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Drugs & Therapeutics for Oral Mucosa Leukoplakia

Drugs for Oral Mucosa Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Rosiglitazone

Approved, Investigational

Phase 2

122320-73-4, 155141-29-0

77999

Celecoxib

Approved, Investigational

Phase 2

169590-42-5

2662

Pembrolizumab

Approved

Phase 2

1374853-91-4

254741536

Nivolumab

Approved

Phase 2

946414-94-4

Metformin

Approved

Phase 2

1115-70-4, 657-24-9

4091

Pioglitazone

Approved, Investigational

Phase 2

111025-46-8

4829

Maleic acid

Experimental, Investigational

Phase 2

110-16-7, 110-17-8

444266 444972

Antirheumatic Agents

Phase 2

Cyclooxygenase Inhibitors

Phase 2

Cyclooxygenase 2 Inhibitors

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Anti-Inflammatory Agents

Phase 2

Analgesics, Non-Narcotic

Phase 2

Analgesics

Phase 2

Immune Checkpoint Inhibitors

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Hypoglycemic Agents

Phase 2

Tea

Phase 2

Aminolevulinic acid

Approved

Phase 1

106-60-5

137

Photosensitizing Agents

Phase 1

Dermatologic Agents

Phase 1

Nitrous oxide

Approved, Vet_approved

10024-97-2

948

Nitric Oxide

Approved

10102-43-9

145068

Fluconazole

Approved, Investigational

86386-73-4

3365

Miconazole

Approved, Investigational, Vet_approved

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

23593-75-1

2812

Heparin, bovine

Approved, Investigational, Withdrawn

9005-49-6

22833565 9812414 772

Sulindac

Approved, Investigational

38194-50-2

5352 1548887

Ethanol

Approved

64-17-5

702

Melatonin

Approved, Nutraceutical, Vet_approved

73-31-4

896

Antioxidants

Protective Agents

Hormones

Anti-Infective Agents

Hormone Antagonists

Antifungal Agents

Cytochrome P-450 Enzyme Inhibitors

Calcium heparin

Hemostatics

Coagulants

Tolonium Chloride

Anesthetics

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia	Completed	NCT00155337	Phase 4
2	Phase IIA Trial of Rosiglitazone (Avandia) for Oral Leukoplakia	Completed	NCT00369174	Phase 2	rosiglitazone maleate
3	A Phase IIb Cancer Prevention Trial of Celecoxib, a Selective COX-2 Inhibitor, in Oral Leukoplakia	Completed	NCT00101335	Phase 2	celecoxib
4	A Phase IIa Cancer Prevention Trial of the PPAR Gamma Agonist Pioglitazone in Oral Leukoplakia	Completed	NCT00099021	Phase 2	pioglitazone hydrochloride
5	Bowman Birk Inhibitor Concentrate and Oral Leukoplakia: A Randomized Phase IIb Trial	Completed	NCT00330382	Phase 2	Bowman-Birk inhibitor concentrate
6	A Phase II Open Label, Single Arm Study to Evaluate the Efficacy of Pembrolizumab for Leukoplakia	Recruiting	NCT03603223	Phase 2
7	Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia	Active, not recruiting	NCT03692325	Phase 2	Nivolumab
8	M4OC-Prevent: Metformin for Oral Cancer Prevention	Active, not recruiting	NCT02581137	Phase 2	Metformin Hydrochloride
9	M4OC-Prevent 2.0: Phase IIb Trial of Metformin for Oral Cancer Prevention	Not yet recruiting	NCT05237960	Phase 2	Extended Release Metformin Hydrochloride;Placebo Administration
10	A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia	Terminated	NCT00176566	Phase 2	Lozenge Intake
11	Phase IIB Randomized, Placebo Controlled Trial of Pioglitazone for Oral Premalignant Lesions an Inter-consortium Collaborative Study	Terminated	NCT00951379	Phase 2	Pioglitazone hydrochloride
12	Phase I Study of Photodynamic Therapy Using Pulsed Dye Laser and Oral Aminolevulinic Acid in Patients With Oral Leukoplakia	Terminated	NCT00571558	Phase 1	aminolevulinic acid hydrochloride;photodynamic therapy
13	A Phase 1, Randomized, Double-blind, Placebo Controlled, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of SBS-101 After Intraoral Application in Patients With Oral Premalignant Lesions (OPL)	Withdrawn	NCT03939364	Phase 1	SBS-101;Placebo
14	Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia: a Pilot Study	Withdrawn	NCT05505539	Phase 1	5-fluorouracil
15	Dental Hygienists and Oral Mucosal Inspection - Extent, Knowledge and Perceived Barriers	Unknown status	NCT04079491
16	Least Invasive Nonlinear Light Microscopy	Unknown status	NCT00767442
17	Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study	Unknown status	NCT04251845
18	Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	Completed	NCT04267419
19	Association of Candida and Antifungal Therapy With Pro-inflammatory Cytokines in Oral Leukoplakia- A Pilot Study	Completed	NCT04712929
20	Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions	Completed	NCT03682562
21	Development of an Oral Epithelial Dysplasia Informational Needs Questionnaire	Completed	NCT04153266
22	Efficacy of Rose Bengal in Comparison With Toluidine Blue in Detection of Premalignant Lesions: a Preliminary Study	Completed	NCT03031899
23	A Pilot Multi-Center International Double-Blind Placebo Controlled Randomized Study of Sulindac, a Pan-Cox Inhibitor, in Oral Premalignant Lesions	Completed	NCT00299195		sulindac;Placebo
24	Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia	Completed	NCT03233165
25	Clinical Evaluation of the OncAlert RAPID; Impact on Decision-Making	Completed	NCT03239834
26	Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity	Completed	NCT01636544
27	Comparison Between Surgical Excision and "Wait and See" Approach in the Treatment of Oral Leukoplakia: a Randomized, Controlled Clinical Trial	Recruiting	NCT04858100
28	Prospective Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore	Recruiting	NCT03975322
29	Fluorescence &Amp; Reflectance Imaging to Detect Oral Neoplasia	Active, not recruiting	NCT00542373
30	Biomarkers for Oral Cancer	Active, not recruiting	NCT00341497
31	THE HONG KONG ORAL CANCER EDUCATION AND SCREENING (HOCES) PROGRAM: REFINING DISEASE PREVENTION, RISK STRATIFICATION AND EARLY DETECTION	Not yet recruiting	NCT04487938
32	Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions	Not yet recruiting	NCT04732741

Search NIH Clinical Center for Oral Mucosa Leukoplakia

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Genetic Tests for Oral Mucosa Leukoplakia

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Anatomical Context for Oral Mucosa Leukoplakia

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Publications for Oral Mucosa Leukoplakia

Articles related to Oral Mucosa Leukoplakia:

(show all 16)

#	Title	Authors	PMID	Year
1	[Oral leukoplakia associated with Human Papilloma Virus; a bipolar infection in a young patient]. ⁶²	Galindez Costa MF...Gilligan GM	33351365	2020
2	Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. ⁶²	Salehi B...Sharifi-Rad J	30884918	2019
3	Evaluating the Role of Immunological Cells (Tissue Eosinophils and Mast Cells) in Progression of Oral Squamous Cell Carcinoma. ⁶²	Saxena S...Bhargava A	29769506	2018
4	[Diagnostic value of optical coherence tomography for oral leukoplakia assessment]. ⁶²	Syomkin VA...Babichenko II	29465074	2018
5	[Leukoplakia: clinical and pathological diagnosis]. ⁶²	Syomkin VA...Bezrukov AA	36475409	2017
6	Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma. ⁶²	Ramsridhar S...Narasimhan M	27656549	2016
7	Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma. ⁶²	Negi A...Mittal M	26457223	2015
8	[Studies on tea and health]. ⁶²	Han C	22279681	2011
9	Actual proliferating index in oral squamous cell carcinoma and leukoplakia. ⁶²	Chandak AR...Wadhwani R	25426788	2011
10	Multimodality approach to optical early detection and mapping of oral neoplasia. ⁶²	Ahn YC...Chen Z	21806268	2011
11	Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia. ⁶²	Raju Ragavendra T...Sowmya K	20070484	2010
12	[A white lesion of the oral mucosa: leukoplakia?]. ⁶²	Gielkens PF...van der Waal I	14640054	2003
13	[Incidence of diabetes mellitus in patients with malignant tumors of the oral cavity]. ⁶²	Ujpal M...Szabo G	12587541	2002
14	The chemopreventive effects of tea on human oral precancerous mucosa lesions. ⁶²	Li N...Chen J	10202392	1999
15	[Dental caries, periodontal diseases and the condition of mouth mucosa in workers of the petrochemical industry]. ⁶²	Wierzbicka M...Sentek B	6645941	1983
16	[Cryotherapy in the treatment of oral mucosa leukoplakia]. ⁶²	Struzak-Wysokinska M	1067928	1976

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Genes for Oral Mucosa Leukoplakia

Genes related to Oral Mucosa Leukoplakia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TEC	Tec Protein Tyrosine Kinase	Protein Coding	4.36	DISEASES inferred ¹⁴
2	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	4.22	DISEASES inferred ¹⁴
3	TPSG1	Tryptase Gamma 1	Protein Coding	4.21	DISEASES inferred ¹⁴
4	CYB5A	Cytochrome B5 Type A	Protein Coding	4.09	DISEASES inferred ¹⁴
5	MAU2	MAU2 Sister Chromatid Cohesion Factor	Protein Coding	4.02	DISEASES inferred ¹⁴
6	RPSA	Ribosomal Protein SA	Protein Coding	4.01	DISEASES inferred ¹⁴
7	TECR	Trans-2,3-Enoyl-CoA Reductase	Protein Coding	4	DISEASES inferred ¹⁴