MCID: ORL015
MIFTS: 46

Oral Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 76 53 15
Squamous Cell Carcinoma of Mouth 73
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 73 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and melanoma. An important gene associated with Oral Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and bone.

Wikipedia : 76 Squamous cell carcinomas (SCCs), also known as epidermoid carcinoma, comprise a number of different... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 32.8 CCAT2 FOXCUT H19 HOTAIR MALAT1 NEAT1
2 melanoma 30.7 H19 HOTAIR MALAT1 MIR100 MIR137 MIR193A
3 esophageal cancer 30.4 CCAT1 H19 HOTAIR MALAT1 MIR21 UCA1
4 leukoplakia 10.8
5 oral leukoplakia 10.7
6 oral submucous fibrosis 10.6
7 lichen planus 10.6
8 hypoxia 10.6
9 oral lichen planus 10.6
10 papilloma 10.4
11 verrucous carcinoma 10.4
12 triple-receptor negative breast cancer 10.4 HOTAIR MALAT1
13 ovarian epithelial cancer 10.4 H19 HOTAIR MALAT1
14 pancreatic ductal adenocarcinoma 10.4 H19 HOTAIR MALAT1 MIR21 UCA1
15 pituitary adenoma 10.4 CCAT2 H19 HOTAIR MALAT1
16 small cell cancer of the lung 10.4 CCAT2 HOTAIR MALAT1 MIR21 TUG1
17 oral cancer 10.4
18 kidney cancer 10.4 H19 HOTAIR MALAT1 MIR21
19 tongue squamous cell carcinoma 10.3 MALAT1 MIR21 UCA1
20 thyroid cancer, nonmedullary, 1 10.3 H19 HOTAIR MALAT1 NEAT1
21 malignant glioma 10.3 CCAT1 HOTAIR NEAT1 TUG1
22 clear cell renal cell carcinoma 10.3 CCAT2 MALAT1 MIR21 TUG1
23 glioblastoma 10.3 H19 HOTAIR MALAT1 MIR137 MIR21 TUG1
24 thyroid cancer 10.3 H19 HOTAIR MALAT1 NEAT1 UCA1
25 gallbladder cancer 10.3 CCAT1 H19 HOTAIR MALAT1 TUG1 UCA1
26 gastrointestinal system cancer 10.3 H19 HOTAIR MALAT1
27 cholangiocarcinoma 10.3 CCAT2 H19 MALAT1 MIR21 NEAT1 TUG1
28 laryngeal squamous cell carcinoma 10.3 CCAT1 H19 HOTAIR MALAT1 MIR21 NEAT1
29 myeloma, multiple 10.3 CCAT1 H19 HOTAIR MALAT1 TUG1 UCA1
30 leukemia, acute myeloid 10.3 CCAT1 HOTAIR MALAT1 MIR21 TUG1 UCA1
31 gastric cardia adenocarcinoma 10.3 H19 HOTAIR
32 ovarian serous carcinoma 10.3 MIR100 MIR21
33 intrahepatic cholangiocarcinoma 10.3 CCAT1 CCAT2 TUG1
34 renal cell carcinoma, nonpapillary 10.3 CCAT1 H19 HOTAIR MALAT1 TUG1 UCA1
35 pre-eclampsia 10.3 H19 HOTAIR MALAT1 TUG1
36 lung cancer susceptibility 3 10.3 CCAT1 H19 HOTAIR MALAT1 TUG1
37 bladder cancer 10.3 CCAT2 H19 HOTAIR MALAT1 MIR100 MIR21
38 osteogenic sarcoma 10.3 CCAT1 CCAT2 H19 HOTAIR MALAT1 NEAT1
39 adamantinoma of long bones 10.3 CCAT1 CCAT2 H19 HOTAIR MALAT1 NEAT1
40 glioma 10.3 CCAT1 CCAT2 H19 HOTAIR MALAT1 MIR21
41 astrocytoma 10.3 H19 HOTAIR MIR21
42 endometrial cancer 10.3 CCAT1 H19 HOTAIR NEAT1 TUG1 UCA1
43 bladder urothelial carcinoma 10.3 HOTAIR MALAT1 TUG1
44 cervical cancer 10.3 CCAT1 CCAT2 H19 HOTAIR MALAT1 MIR21
45 parkinson disease, late-onset 10.3 H19 HOTAIR MALAT1 NEAT1
46 nasopharyngeal carcinoma 10.3 CCAT1 FOXCUT H19 HOTAIR MALAT1 MIR100
47 hypereosinophilic syndrome 10.3
48 b-cell lymphomas 10.3 HOTAIR MALAT1 TUG1
49 pancreatic cancer 10.2 CCAT1 H19 HOTAIR MALAT1 MIR100 MIR21
50 prostate cancer 10.2 CCAT2 H19 HOTAIR MALAT1 MIR100 MIR21

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2, Phase 3,Phase 1 15663-27-1 2767 441203 84093
2
Docetaxel Approved, Investigational Phase 2, Phase 3 114977-28-5 148124
3
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
4
Metformin Approved Phase 3 657-24-9 14219 4091
5 Immunosuppressive Agents Phase 2, Phase 3
6 Antimetabolites Phase 2, Phase 3
7 Antimitotic Agents Phase 2, Phase 3,Early Phase 1
8 Immunologic Factors Phase 2, Phase 3,Not Applicable
9 Antimetabolites, Antineoplastic Phase 2, Phase 3
10 Hypoglycemic Agents Phase 3
11
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
12
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
13
Paclitaxel Approved, Vet_approved Phase 2,Early Phase 1 33069-62-4 36314
14 Raspberry Approved Phase 1, Phase 2,Not Applicable
15
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
16 Anti-Inflammatory Agents Phase 2
17 Analgesics Phase 2
18 Cyclooxygenase 2 Inhibitors Phase 2
19 Cyclooxygenase Inhibitors Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Antirheumatic Agents Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2
24 Mitogens Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 2,Early Phase 1
26 Albumin-Bound Paclitaxel Phase 2,Early Phase 1
27 Antioxidants Phase 2
28 Protective Agents Phase 2
29 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
30 Pharmaceutical Solutions Phase 1, Phase 2
31 Protein Kinase Inhibitors Phase 2
32
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
33
Ethanol Approved Not Applicable 64-17-5 702
34
Heparin Approved, Investigational 9005-49-6 772 46507594
35
Licorice Approved Early Phase 1
36
Phenol Approved, Experimental Early Phase 1 108-95-2 996
37 Lugol's solution Not Applicable
38 calcium heparin
39 Coagulants
40 Hemostatics
41 Tolonium Chloride
42 Platelet Aggregation Inhibitors
43
Diadenosine tetraphosphate 5542-28-9 21706
44 Antibodies, Monoclonal
45 Antibodies ,Not Applicable
46 Immunoglobulins ,Not Applicable
47 Antimalarials Early Phase 1
48 Antiviral Agents Early Phase 1
49 Anti-Bacterial Agents Early Phase 1

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL Unknown status NCT01039298 Phase 3
2 TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
3 Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions Recruiting NCT03685409 Phase 3 Metformin Hydrochloride 500 MG;Placebo Oral Tablet
4 Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma Unknown status NCT02739204 Phase 2 Celecoxib
5 A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
6 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
7 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed NCT01192204 Phase 1, Phase 2 10% FBR containing bioadhesive gel;placebo gel
8 Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma Recruiting NCT03502148 Phase 1, Phase 2 PRV111 (Cisplatin Transmucosal System)
9 A Dye for the Detection of Cancer of the Tongue and Mouth Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
10 Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage Recruiting NCT02290145 Phase 2 TPF group
11 GDF15 Based TPF Induction Chemotherapy for OSCC Patients Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
12 Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study Recruiting NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
13 A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients Active, not recruiting NCT02285543 Phase 2 TPF induction chemotherapy
14 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
15 Gene Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00009841 Phase 1 DC-cholesterol liposome
16 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
17 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
18 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
19 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
20 Neck Surgery in Treating Patients With Early-Stage Oral Cancer Unknown status NCT00571883 Not Applicable
21 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable
22 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544 Not Applicable
23 The Functional and Clinicopathological Roles and Therapeutic Implication of Connective Tissue Growth Factor in Peritoneal Metastasis of Gastric Cancer Unknown status NCT01627119
24 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
25 Epstein-Barr Detection in Oral Cancer Completed NCT01039272
26 One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma Completed NCT02852343
27 Fluorescent Visualization in Early Oral Cancer Completed NCT02306967 Not Applicable
28 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
29 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
30 Freeze-Dried Black Raspberries in Treating Patients With Oral Squamous Cell Cancer Undergoing Surgery Completed NCT01465776 Not Applicable
31 Human Papillomavirus on Oral Tissue, Saliva and Serum Completed NCT01043328
32 Autofluorescence for the Screening of Precancerous and Malignant Lesions Completed NCT01167790 Not Applicable
33 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia Completed NCT00835341
34 Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma Recruiting NCT03554967
35 Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma Recruiting NCT01334320 Not Applicable
36 A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. Recruiting NCT02743832 Not Applicable
37 Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer Recruiting NCT01587573
38 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Recruiting NCT03418454
39 Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer Recruiting NCT00899704
40 Submandibular Gland Preservation in Neck Dissection Active, not recruiting NCT03385720 Not Applicable
41 Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer Active, not recruiting NCT03053960
42 Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer Active, not recruiting NCT01772706 Not Applicable
43 Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients Active, not recruiting NCT03529604
44 Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03619304 Not Applicable
45 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma Not yet recruiting NCT03109457
46 Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Not yet recruiting NCT03345966 Not Applicable
47 Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03292822 Early Phase 1 Paclitaxel
48 Characterization of the Fungal Origins in the Autoimmune Polyendocrinopathy of Type 1 Compared With the Autoimmune Polyendocrinopathies of Type 2 Not yet recruiting NCT03800056
49 Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors Terminated NCT02975739 Not Applicable

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

41
Lymph Node, Endothelial, Bone, Skin, T Cells, Tongue, Neutrophil

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 2868)
# Title Authors Year
1
Suicide Gene Therapy for Oral Squamous Cell Carcinoma. ( 30539528 )
2019
2
Suicide Gene Therapy of Oral Squamous Cell Carcinoma and Cervical Carcinoma In Vitro. ( 30539538 )
2019
3
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-κB pathway. ( 30551455 )
2019
4
Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3. ( 30320347 )
2019
5
Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression in adjacent non-tumour epithelium in oral squamous cell carcinoma. ( 30321764 )
2019
6
Management of the Neck in Oral Squamous Cell Carcinoma: Background, Classification, and Current Philosophy. ( 30449527 )
2019
7
Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma. ( 30070696 )
2019
8
Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma. ( 30197859 )
2019
9
Analysis of stromal mucin in oral epithelial dysplasia & oral squamous cell carcinoma- A histochemical study. ( 30210999 )
2019
10
XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. ( 29916547 )
2018
11
Serum bilirubin level predicts post-operative overall survival in oral squamous cell carcinoma. ( 29430757 )
2018
12
CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma. ( 29360827 )
2018
13
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. ( 29464350 )
2018
14
TGF-I^1/TI^RII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages. ( 29462614 )
2018
15
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma. ( 29491060 )
2018
16
Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma. ( 29900911 )
2018
17
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors. ( 29963189 )
2018
18
Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma. ( 29620248 )
2018
19
Human Papilloma Virus 16/18: Fabricator of Trouble in Oral Squamous Cell Carcinoma. ( 29432879 )
2018
20
Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator. ( 29422466 )
2018
21
CD47 as a potential prognostic marker for oral leukoplakia and oral squamous cell carcinoma. ( 29805639 )
2018
22
Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids. ( 29435298 )
2018
23
Oral squamous cell carcinoma profile in North-Eastern regions of India from habits to histopathology: A hospital-based study. ( 29937660 )
2018
24
[Corrigendum] Long nona89coding RNAA H19 promotes cell proliferation and invasion by acting as a ceRNA of miRa89138 and releasing EZH2 in oral squamous cell carcinoma. ( 29901192 )
2018
25
Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line. ( 29435078 )
2018
26
Meta-analysis of the prognostic value of the neutrophil-to-lymphocyte ratio in oral squamous cell carcinoma. ( 29406591 )
2018
27
Frequency of circulating CD14<sup>++</sup> CD16<sup>+</sup> intermediate monocytes as potential biomarker for the diagnosis of oral squamous cell carcinoma. ( 29961993 )
2018
28
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. ( 29911943 )
2018
29
Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With Histologic Risk Factors: Are We Over-Treating? ( 29438656 )
2018
30
MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. ( 29407635 )
2018
31
PDGFRI+/HER2 and PDGFRI+/p53 Co-expression in Oral Squamous Cell Carcinoma. ( 29374704 )
2018
32
Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. ( 29423682 )
2018
33
Tumor budding is associated with poor prognosis of oral squamous cell carcinoma and histologically represents an epithelial-mesenchymal transition process. ( 29936060 )
2018
34
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. ( 29970504 )
2018
35
Immunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma. ( 29964301 )
2018
36
The possible contemporary presence of BRONJ and oral squamous cell carcinoma. ( 29941328 )
2018
37
miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling. ( 29364705 )
2018
38
Dermoscopy Of Oral Squamous Cell Carcinoma. ( 29938447 )
2018
39
Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. ( 29433680 )
2018
40
Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis. ( 29652009 )
2018
41
Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature. ( 29433990 )
2018
42
DDR2 overexpression in oral squamous cell carcinoma is associated to lymph node metastasis. ( 29945346 )
2018
43
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
44
Sequential injection of radioactive nanosized colloids followed by indocyanine green for sentinel lymph node detection in oral squamous cell carcinoma: A proof of concept. ( 29429631 )
2018
45
Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma. ( 29171106 )
2018
46
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma. ( 29416107 )
2018
47
A Noninvasive Test for MicroRNA Expression in Oral Squamous Cell Carcinoma. ( 29914173 )
2018
48
Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. ( 29444110 )
2018
49
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. ( 29074611 )
2018
50
Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factora89related apoptosisa89inducing liganda89induced oral squamous cell carcinoma apoptosis and suppresses proliferation inA vitro and inA vivo. ( 29901096 )
2018

Variations for Oral Squamous Cell Carcinoma

Cosmic variations for Oral Squamous Cell Carcinoma:

9 (show top 50) (show all 1098)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM3724309 ZNF536 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1935G>C p.Q645H 19:30445497-30445497 16
2 COSM6976115 YES1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1288C>T p.Q430* 18:736811-736811 16
3 COSM6914703 XPO1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.619C>G p.Q207E 2:61498885-61498885 16
4 COSM6957917 TSC2 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 16
5 COSM121050 TP63 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.551C>T p.S184L 3:189808498-189808498 16
6 COSM10645 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 16
7 COSM69404 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 16
8 COSM43708 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 16
9 COSM11073 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 16
10 COSM43947 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 16
11 COSM10660 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 16
12 COSM45607 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.676G>A p.G226S 17:7674287-7674287 16
13 COSM43592 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.395A>T p.K132M 17:7675217-7675217 16
14 COSM45794 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.421T>G p.C141G 17:7675191-7675191 16
15 COSM43850 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 16
16 COSM43606 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.734G>A p.G245D 17:7674229-7674229 16
17 COSM10958 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>T p.G266V 17:7673823-7673823 16
18 COSM44351 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 16
19 COSM10648 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 16
20 COSM11084 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>A p.V173M 17:7675095-7675095 16
21 COSM43665 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.746G>C p.R249T 17:7674217-7674217 16
22 COSM10756 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.827C>T p.A276V 17:7673793-7673793 16
23 COSM10663 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 16
24 COSM10659 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 16
25 COSM45618 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.931A>C p.N311H 17:7673597-7673597 16
26 COSM43695 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 16
27 COSM44229 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.515T>A p.V172D 17:7675097-7675097 16
28 COSM10704 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 16
29 COSM44935 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.724T>A p.C242S 17:7674239-7674239 16
30 COSM10758 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 16
31 COSM43714 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 16
32 COSM10646 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>A p.C242Y 17:7674238-7674238 16
33 COSM43743 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.914A>G p.K305R 17:7673706-7673706 16
34 COSM10905 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 16
35 COSM10656 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 16
36 COSM10735 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 16
37 COSM10662 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 16
38 COSM44823 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.981T>G p.Y327* 17:7673547-7673547 16
39 COSM43906 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.843C>A p.D281E 17:7673777-7673777 16
40 COSM10724 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 16
41 COSM43680 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 16
42 COSM43559 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 16
43 COSM10863 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.833C>T p.P278L 17:7673787-7673787 16
44 COSM43772 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.538G>A p.E180K 17:7675074-7675074 16
45 COSM44393 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 16
46 COSM10728 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>A p.R280K 17:7673781-7673781 16
47 COSM11286 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1015G>T p.E339* 17:7670694-7670694 16
48 COSM10808 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.488A>G p.Y163C 17:7675124-7675124 16
49 COSM44449 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.415A>G p.K139E 17:7675197-7675197 16
50 COSM10788 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.764T>G p.I255S 17:7674199-7674199 16

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification EMS1 Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification TAOS1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification ORAOV1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 HOTAIR UCA1

GO Terms for Oral Squamous Cell Carcinoma

Cellular components related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 micro-ribonucleoprotein complex GO:0035068 9.1 H19 MIR100 MIR137 MIR193A MIR21 NEAT1

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.33 MIR137 MIR193A MIR21
2 negative regulation of blood vessel endothelial cell migration GO:0043537 9.32 MIR137 MIR193A
3 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.26 MIR137 MIR21
4 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.13 MIR137 MIR193A MIR21
5 gene silencing by miRNA GO:0035195 9.1 H19 MIR100 MIR137 MIR193A MIR21 NEAT1

Sources for Oral Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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