MCID: ORL015
MIFTS: 43

Oral Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 74 52 15 17
Squamous Cell Carcinoma of Mouth 71
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 71 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and tongue squamous cell carcinoma. An important gene associated with Oral Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include lymph node, tongue and bone.

Wikipedia : 74 Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 33.6 UCA1 TUG1 NEAT1 MALAT1 HOTAIR H19
2 tongue squamous cell carcinoma 32.1 UCA1 MIR21 MEG3 MALAT1
3 b-cell lymphoma 31.6 TUG1 MIR21 MALAT1 HOTAIR
4 melanoma 31.4 UCA1 MIR193A MIR137 MIR100 MEG3 MALAT1
5 esophageal cancer 31.3 UCA1 MIR21 MIR193A MIR100 MEG3 MALAT1
6 bladder cancer 31.3 UCA1 TUG1 MIR21 MIR193A MIR100 MEG3
7 lung cancer susceptibility 3 31.2 TUG1 MIR21 MIR193A MEG3 MALAT1 HOTAIR
8 retinitis pigmentosa 11 31.2 UCA1 NEAT1 HOTAIR
9 colorectal cancer 31.1 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
10 pancreatic ductal adenocarcinoma 31.1 UCA1 MIR21 MALAT1 HOTAIR H19
11 hepatocellular carcinoma 31.1 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
12 nasopharyngeal carcinoma 31.0 NEAT1 MIR21 MIR100 MEG3 MALAT1 HOTAIR
13 osteogenic sarcoma 31.0 UCA1 TUG1 NEAT1 MEG3 MALAT1 HOTAIR
14 leukemia, acute myeloid 31.0 UCA1 TUG1 MIR21 MIR193A MEG3 MALAT1
15 ovarian cancer 31.0 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR100
16 prostate cancer 31.0 UCA1 TUG1 NEAT1 MIR21 MIR100 MEG3
17 thyroid cancer, nonmedullary, 1 30.9 NEAT1 MEG3 MALAT1 HOTAIR H19
18 gastric cancer 30.9 UCA1 TUG1 NEAT1 MIR21 MEG3 MALAT1
19 myeloma, multiple 30.8 UCA1 TUG1 MIR21 MEG3 MALAT1 HOTAIR
20 gallbladder cancer 30.8 UCA1 TUG1 MEG3 MALAT1 HOTAIR H19
21 laryngeal squamous cell carcinoma 30.8 NEAT1 MIR21 MALAT1 HOTAIR H19 CCAT1
22 kidney cancer 30.8 MIR21 MIR193A MEG3 MALAT1 HOTAIR H19
23 glioma 30.8 UCA1 NEAT1 MIR21 MEG3 MALAT1 HOTAIR
24 cervical cancer 30.8 UCA1 TUG1 NEAT1 MIR21 MEG3 MALAT1
25 lung cancer 30.7 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
26 renal cell carcinoma, nonpapillary 30.7 UCA1 TUG1 MIR21 MIR193A MALAT1 HOTAIR
27 endometrial cancer 30.6 UCA1 TUG1 NEAT1 MIR193A MEG3 HOTAIR
28 lung squamous cell carcinoma 30.6 TUG1 MEG3 CCAT2 CCAT1
29 pre-eclampsia 30.5 TUG1 MALAT1 HOTAIR H19
30 meningioma, radiation-induced 30.1 MEG3 H19
31 oral cancer 11.4
32 leukoplakia 11.0
33 oral leukoplakia 10.9
34 lichen planus 10.8
35 glioma susceptibility 1 10.8 TUG1 MIR21 MIR137 MEG3 MALAT1 HOTAIR
36 oral lichen planus 10.8
37 oral submucous fibrosis 10.8
38 small cell cancer of the lung 10.8 TUG1 MIR21 MALAT1 HOTAIR CCAT2
39 esophagus squamous cell carcinoma 10.8 TUG1 MEG3 HOTAIR
40 papilloma 10.7
41 squamous cell papilloma 10.7
42 bladder urothelial carcinoma 10.7 UCA1 TUG1 MEG3 MALAT1 HOTAIR
43 cholangiocarcinoma 10.7 UCA1 TUG1 NEAT1 MIR21 MALAT1 H19
44 pituitary adenoma 10.7 MEG3 MALAT1 HOTAIR H19 CCAT2
45 gastric cardia adenocarcinoma 10.7 MEG3 HOTAIR H19
46 tongue carcinoma 10.7
47 functionless pituitary adenoma 10.7 MEG3 HOTAIR
48 astrocytoma 10.7 UCA1 NEAT1 MIR21 HOTAIR H19
49 clear cell renal cell carcinoma 10.7 TUG1 MIR21 MEG3 MALAT1 CCAT2
50 in situ carcinoma 10.7

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Phase 3 73-31-4 896
2 Antioxidants Phase 3
3 Protective Agents Phase 3
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
6
Fluorouracil Approved Phase 2 51-21-8 3385
7
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
8
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
9
Morphine Approved, Investigational Phase 1, Phase 2 57-27-2 5288826
10
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
11
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
12
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
13
Calcitriol Approved, Nutraceutical Phase 1, Phase 2 32222-06-3 5280453 134070
14
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 1406-16-2
15
Nimotuzumab Investigational Phase 2 828933-61-3, 780758-10-3
16 Omega 3 Fatty Acid Phase 2
17 Albumin-Bound Paclitaxel Phase 2
18 Micronutrients Phase 1, Phase 2
19 Vitamins Phase 1, Phase 2
20 Trace Elements Phase 1, Phase 2
21 Hormones Phase 1, Phase 2
22 Vasoconstrictor Agents Phase 1, Phase 2
23 Dihydroxycholecalciferols Phase 1, Phase 2
24 Nutrients Phase 1, Phase 2
25 Calcium, Dietary Phase 1, Phase 2
26 Calciferol Phase 1, Phase 2
27 Immunoglobulins Phase 1, Phase 2
28 Antibodies Phase 1, Phase 2
29 Antibodies, Monoclonal Phase 1, Phase 2
30 Immunologic Factors Phase 2
31 Pharmaceutical Solutions Phase 1, Phase 2
32 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
33 Immunosuppressive Agents Phase 2
34 Antimetabolites Phase 2
35 Insulin, Globin Zinc Phase 1, Phase 2
36 insulin Phase 1, Phase 2
37 Analgesics, Non-Narcotic Phase 2
38 Cyclooxygenase 2 Inhibitors Phase 2
39 Analgesics Phase 2
40 Cyclooxygenase Inhibitors Phase 2
41 Anti-Inflammatory Agents Phase 2
42 Antirheumatic Agents Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 2
44 Protein Kinase Inhibitors Phase 2
45 Mitogens Phase 2
46
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
47 Tubulin Modulators Phase 2
48 Antimitotic Agents Phase 2
49 Antineoplastic Agents, Immunological Phase 2
50
Arginine Investigational, Nutraceutical Phase 2 74-79-3 6322

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Adjuvant Radiotherapy in Patients With Oropharyngeal and Floor of Mouth Squamous Cell Carcinoma and Concomitant Histological Verification of Singular Ipsilateral Cervical Lymph Node Metastasis (pN1-state) Unknown status NCT00964977 Phase 3
2 Canadian Optically Guided Approach for Oral Lesions Surgical Trial - COOLS Unknown status NCT01039298 Phase 3
3 Study of TPF (Docetaxel, Cisplatin, 5-fluorouracil) Induction Chemotherapy Followed by Surgery and Radiotherapy in Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
4 Effect of Melatonin in Combination With Neoadjuvant Chemotherapy to HIF-1⍺, CD44, CD133, and miR-210 Expression and Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT04137627 Phase 3 Melatonin 20 MG Oral Capsule;Placebo oral capsule
5 Development of Novel Diagnostic Tools and Therapeutic Strategies for Oral Cancer Unknown status NCT02739204 Phase 2 Celecoxib
6 Randomized Placebo- Controlled Pilot Study of ZD6474 as a Chemopreventive Agent for Premalignant Lesions of the Head and Neck Unknown status NCT01414426 Phase 2 vandetanib
7 A Double Blind, Randomised, Placebo Controlled, Feasibility Phase III Clinical Trial of Peri-operative Immune-enhancing Feed in Patients Undergoing Surgery for Advanced Head and Neck Cancer Completed NCT01314755 Phase 2
8 A Phase II Study of Neoadjuvant Bio-chemotherapy With Cetuximab, Paclitaxel, and Cisplatin (CPC) Followed by Cetuximab-based Concurrent Bio-radiotherapy in High-risk Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
9 Treatment of Oral Lichen Planus Lesions Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
10 Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity Completed NCT00953849 Phase 1, Phase 2 Celecoxib;Calcitriol;Celecoxib plus Calcitriol
11 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed NCT01192204 Phase 1, Phase 2 10% FBR containing bioadhesive gel;placebo gel
12 Phase 1/2, Open-Label, Single-Arm Safety and Efficacy Dose-Finding, Systemic Exposure, and Device Technical Effects of PRV111 (Cisplatin Transmucosal System) in Subjects With Oral Squamous Cell Carcinoma Recruiting NCT03502148 Phase 1, Phase 2 PRV111 (Cisplatin Transmucosal System)
13 A Phase I/II Study of the Fluorescent PARP1 Binding Imaging Agent PARPi-FL in Patients With Oral Squamous Cell Carcinomas Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
14 Cyclin D1 Based TPF(Docetaxel, Cisplatin and 5-fluorouracil) Induction Chemotherapy for OSCC(Oral Squamous Cell Carcinoma) Patients at cN2(Clinical Node 2) Stage: a Phase II Randomized Controlled Trial Recruiting NCT02290145 Phase 2 TPF group
15 A Randomized Phase II Trial of TPF Induction Chemotherapy in cN2 Patients With Oral Squamous Cell Carcinoma Recruiting NCT02285543 Phase 2 TPF induction chemotherapy
16 GDF15 (Growth Differentiation Factor 15) Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at T3/T4cN0M0 Stage: a Phase II Randomized Controlled Trial Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
17 A Randomized Phase II Trial of Low Stathmin Expression as a Predictive Biomarker for OSCC Patients Receiving TPF Induction Chemotherapy Followed by Radical Surgery and Radiotherapy/Chemoradiotherapy Recruiting NCT03326947 Phase 2 docetaxel, cisplatin and 5-fluorouracil
18 A Phase I/II Trial of the Insulin-Like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination With the Src Family Kinase (SFK) Inhibitor Dasatinib in Patients With Embryonal and Alveolar Rhabdomyosarcoma Recruiting NCT03041701 Phase 1, Phase 2 Dasatinib;Ganitumab
19 Effect of COX-2 (Cyclooxygenase-2) and EGFR (Epidermal Growth Factor Receptor) Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study. Active, not recruiting NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
20 A Phase II, Prospective, Single-center, Randomized, Controlled Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squamous Cell Carcinoma Not yet recruiting NCT04367909 Phase 2 Nimotuzumab;Docetaxel;Carboplatin
21 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
22 Phase I Trial Of Intratumoral EGFR Antisense DNA And DC-Chol Liposomes In Advanced Oral Squamous Cell Carcinoma Completed NCT00009841 Phase 1 DC-cholesterol liposome
23 Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma: A Single-arm Phase I Trial Recruiting NCT04393506 Phase 1 Camrelizumab;Apatinib
24 Safety and Efficacy Evaluation of Carrimycin in Patients With Locally Advanced, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma (Non NPC): A Phase I Trial Recruiting NCT04413214 Phase 1 Carrimycin
25 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
26 Pivotal Validation Study of Salivary Biomarkers for the Risk Stratification of Patients With Lesions Suspicious for Oral Squamous Cell Carcinoma Unknown status NCT01587573
27 Validation of Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Unknown status NCT03345966
28 Apoptotic and Anti-Proliferative Effects of Licorice Extract (Licochalcone A) and Paclitaxel Chemotherapy on Human Oral Squamous Cell Carcinoma Cell Line Unknown status NCT03292822 Early Phase 1 Paclitaxel
29 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
30 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
31 SEND Trial The Role of Selective Neck Dissection Used Electively in Patients With Early Oral Squamous Cell Carcinoma (1-3cm Primary Size) and No Clinical Evidence of Lymph Node Metastases in the Neck Unknown status NCT00571883
32 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus. Diagnostic Value of White Light Endoscopy, Narrow Band Imaging and Chromoendoscopy for Detection of Esophageal Manifestation in Patients With Oral Lichen. Unknown status NCT02532166
33 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
34 The Relation of Microtubule-Associated Protein 2 and Cell Migration Unknown status NCT00174109
35 The Functional and Clinicopathological Roles and Therapeutic Implication of Connective Tissue Growth Factor in Peritoneal Metastasis of Gastric Cancer Unknown status NCT01627119
36 A Phase 1b Pilot Study Evaluating Oral Administration of Freeze-Dried Black Raspberries in Pre-Surgical Patients With Oral Squamous Cell Carcinoma Completed NCT01465776
37 Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma Completed NCT03554967
38 Epstein-Barr Detection in Squamous Cell Carcinoma and Healthy Oral Mucosa Completed NCT01039272
39 Modern Hybrid Imaging for Staging and Monitoring Patients With Oral Squamous Cell Carcinoma Completed NCT04280159
40 Fluorescent Visualization in Early Oral Cancer Completed NCT02306967
41 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma. (Retrospective-cohort Study) Completed NCT03109457
42 Molecular Mechanisms of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
43 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma. Completed NCT02323672
44 A Cohort Study on Prediction of Malignant Transformation of Oral Epithelial Dysplasia by p16 Methylation Completed NCT00835341
45 Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma? Completed NCT00693550
46 Detection of Salivary 8-Hydroxy-2-Deoxyguanosine and Total Antioxidant Capacity in Patients With Oral Premalignant and Malignant Lesions Completed NCT03830710
47 Interest of Oral Tissue Autofluorescence for the Screening of Precancerous Lesions and Cancer in Population With Tobacco and Alcohol Abuse. Completed NCT01167790
48 Assessing Efficacy of Neoadjuvant Chemoradiotherapy as a Treatment Plan for Patients With Stage IVa Oral Cancer. Completed NCT03923998 Early Phase 1 Neoadjuvant chemotherapy
49 Comparison of Detection of Human Papillomavirus on Tissue, Saliva and Serum Completed NCT01043328
50 Real-time Semi-quantification of Endoscopic Ultrasound Elastography and Contrast-enhancement Using Strain Histograms (SH) and Contrast-enhancement (CE) for the Differentiation of Focal Pancreatic Masses and the Assessment of Lymph Node Involvement Completed NCT02459041

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

40
Lymph Node, Tongue, Bone, Endothelial, T Cells, Neutrophil, Skin

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 9524)
# Title Authors PMID Year
1
Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. 46 61
19396866 2009
2
The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. 46 61
19435529 2009
3
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. 61 46
18381414 2008
4
Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. 46
18946016 2008
5
Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis. 61
32466707 2020
6
R2TP/PAQosome as a promising chemotherapeutic target in cancer. 61
31890057 2020
7
MiR-132 inhibits migration and invasion and increases chemosensitivity of cisplatin-resistant oral squamous cell carcinoma cells via targeting TGF-β1. 61
31906769 2020
8
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway. 61
32017846 2020
9
Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway. 61
32407849 2020
10
Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway. 61
32502840 2020
11
Human Papillomavirus E6/E7 mRNA detection by in situ hybridization in oral cavity squamous cell carcinoma. 61
32464412 2020
12
MicroRNA-345 functions as a tumor suppressor via targeting ZEB2 in oral squamous cell carcinoma. 61
32445972 2020
13
Light stimulus responsive nanomedicine in the treatment of oral squamous cell carcinoma. 61
32402938 2020
14
Automated classification of cells into multiple classes in epithelial tissue of oral squamous cell carcinoma using transfer learning and convolutional neural network. 61
32416467 2020
15
Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach. 61
31748878 2020
16
Prognostic and clinicopathological significance of PD-L1 overexpression in oral squamous cell carcinoma: A systematic review and comprehensive meta-analysis. 61
32330687 2020
17
A Phase 2 Trial of Chemoradiation Therapy Using Weekly Docetaxel for High-Risk Postoperative Oral Squamous Cell Carcinoma Patients. 61
32126267 2020
18
Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines. 61
32319646 2020
19
Combination of celecoxib and calyculin-A inhibits epithelial-mesenchymal transition in human oral cancer cells. 61
31937145 2020
20
Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression. 61
32320683 2020
21
Repertoire of peripheral T cells in patients with oral squamous cell carcinoma. 61
32097519 2020
22
Predictive value of prognostic nutritional index in patients with oral squamous cell carcinoma. 61
32125746 2020
23
SATB2 knockdown decreases hypoxia-induced autophagy and stemness in oral squamous cell carcinoma. 61
32566006 2020
24
Identification and validation of seven prognostic long non-coding RNAs in oral squamous cell carcinoma. 61
32566023 2020
25
Identification of Differentially Expressed Proteins from Smokeless Tobacco Addicted Patients Suffering from Oral Squamous Cell Carcinoma. 61
31446608 2020
26
Focal Adhesion Kinase (FAK) Overexpression and Phosphorylation in Oral Squamous Cell Carcinoma and their Clinicopathological Significance. 61
31522363 2020
27
Periodontitis and oral Cancer-A striking link. 61
32147310 2020
28
Oral cancer in a 5-year-old boy: a rare case report and review of literature. 61
32312529 2020
29
Porphyromonas gingivalis Promotes Immunoevasion of Oral Cancer by Protecting Cancer from Macrophage Attack. 61
32471882 2020
30
Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma - an Immunohistochemical Analysis. 61
31489575 2020
31
The role of long non-coding RNA CASC2 in the carcinogenesis process. 61
32559846 2020
32
Epithelial-Mesenchymal Transition Predicts Survival in Oral Squamous Cell Carcinoma. 61
31471883 2020
33
TGF-β1 induces N-cadherin expression by upregulating Sox9 expression and promoting its nuclear translocation in human oral squamous cell carcinoma cells. 61
32565972 2020
34
Long non-coding RNA SLC16A1-AS1: its multiple tumorigenesis features and regulatory role in cell cycle in oral squamous cell carcinoma. 61
32450050 2020
35
Activin A triggers angiogenesis via regulation of VEGFA and its overexpression is associated with poor prognosis of oral squamous cell carcinoma. 61
32377747 2020
36
Assessment of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma. 61
32027861 2020
37
Characterisation of a subpopulation of CD133+ cancer stem cells from Chinese patients with oral squamous cell carcinoma. 61
32483269 2020
38
Correction to: Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop. 61
31853006 2020
39
BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene. 61
32499570 2020
40
Myeloid-derived suppressor cells impede T cell functionality and promote Th17 differentiation in oral squamous cell carcinoma. 61
32103293 2020
41
Prognostic ability of DNA-binding protein inhibitor ID-1 expression in patients with oral squamous cell carcinoma. 61
32382338 2020
42
Elective neck dissection versus observation for early-stage oral squamous cell carcinoma: Systematic review and meta-analysis. 61
32244173 2020
43
Specific Deletion of p16INK4a with Retention of p19ARF Enhances the Development of Invasive Oral Squamous Cell Carcinoma. 61
32194051 2020
44
Expression of Concern: MUC1 gene silencing inhibits proliferation, invasion and migration while promoting apoptosis of oral squamous cell carcinoma cells. 61
32579205 2020
45
CircRNA_002178 promotes the proliferation and migration of oral squamous cell carcinoma cells by activating the Akt/mTOR pathway. 61
32572877 2020
46
LINE-1 retrotransposon encoded ORF1p expression and promoter methylation in oral squamous cell carcinoma: a pilot study. 61
32088612 2020
47
Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: a pilot study. 61
32546692 2020
48
METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification. 61
32145676 2020
49
Mass Spectrometry-Based Lipidomics of Oral Squamous Cell Carcinoma Tissue Reveals Aberrant Cholesterol and Glycerophospholipid Metabolism - A Pilot Study. 61
32559714 2020
50
Prognostic value of log odds of positive lymph nodes in patients with resectable oral squamous cell carcinoma. 61
32535340 2020

Variations for Oral Squamous Cell Carcinoma

Cosmic variations for Oral Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification EMS1 Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification TAOS1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification ORAOV1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 UCA1 MEG3 HOTAIR

GO Terms for Oral Squamous Cell Carcinoma

Cellular components related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.8 MIR21 MIR193A MIR100

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.33 MIR21 MIR193A MIR137
2 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.26 MIR21 MIR137
3 gene silencing by miRNA GO:0035195 9.17 NEAT1 MIR21 MIR193A MIR137 MIR100 MEG3
4 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.13 MIR21 MIR193A MIR137

Molecular functions related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.92 MIR21 MIR193A MIR137 MIR100

Sources for Oral Squamous Cell Carcinoma

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