MCID: ORL015
MIFTS: 43

Oral Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 73 20 15 17
Squamous Cell Carcinoma of Mouth 70
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 70 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and tongue squamous cell carcinoma. An important gene associated with Oral Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Melatonin and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, tongue and endothelial.

Wikipedia : 73 Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 337)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 33.7 UCA1 TUG1 NEAT1 MALAT1 HOTAIR H19
2 tongue squamous cell carcinoma 32.0 UCA1 MIR21 MEG3 MALAT1
3 b-cell lymphoma 31.6 TUG1 MIR21 MALAT1 HOTAIR
4 melanoma 31.5 UCA1 MIR193A MIR137 MIR100 MEG3 MALAT1
5 glioblastoma 31.5 TUG1 MIR21 MIR137 MEG3 MALAT1 HOTAIR
6 lung cancer susceptibility 3 31.5 TUG1 MIR21 MEG3 MALAT1 HOTAIR H19
7 esophageal cancer 31.4 UCA1 MIR21 MIR193A MIR100 MEG3 MALAT1
8 nasopharyngeal carcinoma 31.2 NEAT1 MIR21 MIR100 MEG3 MALAT1 HOTAIR
9 retinitis pigmentosa 11 31.1 UCA1 NEAT1 HOTAIR
10 osteogenic sarcoma 31.1 UCA1 TUG1 NEAT1 MEG3 MALAT1 HOTAIR
11 bladder cancer 31.0 UCA1 TUG1 MIR21 MIR193A MIR100 MEG3
12 pancreatic ductal adenocarcinoma 31.0 UCA1 MIR21 MALAT1 HOTAIR H19
13 lung cancer 31.0 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
14 leukemia, acute myeloid 31.0 UCA1 TUG1 MIR21 MIR193A MEG3 MALAT1
15 renal cell carcinoma, nonpapillary 31.0 UCA1 TUG1 MIR21 MIR193A MALAT1 HOTAIR
16 myeloma, multiple 30.9 UCA1 TUG1 MIR21 MEG3 MALAT1 HOTAIR
17 thyroid cancer, nonmedullary, 1 30.8 NEAT1 MEG3 MALAT1 HOTAIR H19
18 cervical cancer 30.8 UCA1 TUG1 NEAT1 MIR21 MEG3 MALAT1
19 thyroid carcinoma 30.8 UCA1 NEAT1 MALAT1 HOTAIR H19
20 kidney cancer 30.8 MIR21 MEG3 MALAT1 HOTAIR H19
21 endometrial cancer 30.7 UCA1 TUG1 NEAT1 MIR193A MEG3 HOTAIR
22 ovarian cancer 30.6 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR100
23 pre-eclampsia 30.6 TUG1 MALAT1 HOTAIR H19
24 oral cancer 11.5
25 leukoplakia 11.1
26 oral leukoplakia 11.1
27 lichen planus 10.9
28 oral lichen planus 10.9
29 oral submucous fibrosis 10.9
30 papilloma 10.8
31 squamous cell papilloma 10.8
32 tongue carcinoma 10.8
33 in situ carcinoma 10.8
34 fibrosis of extraocular muscles, congenital, 1 10.8
35 hypoxia 10.7
36 mucositis 10.7
37 oral cavity cancer 10.7
38 verrucous carcinoma 10.7
39 severe combined immunodeficiency 10.6
40 keratosis 10.6
41 oculopharyngeal muscular dystrophy 10.6
42 hypereosinophilic syndrome 10.6
43 oral mucosa leukoplakia 10.6
44 bone resorption disease 10.6
45 small cell cancer of the lung 10.6 TUG1 MIR21 MALAT1 HOTAIR CCAT2
46 cholangiocarcinoma 10.6 UCA1 TUG1 NEAT1 MIR21 MALAT1 H19
47 47,xyy 10.6
48 gallbladder cancer 10.6 UCA1 TUG1 MEG3 MALAT1 HOTAIR H19
49 glioma 10.6 UCA1 NEAT1 MIR21 MEG3 MALAT1 HOTAIR
50 laryngeal squamous cell carcinoma 10.6 NEAT1 MIR21 MALAT1 HOTAIR H19 CCAT1

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Phase 3 73-31-4 896
2 Protective Agents Phase 3
3 Antioxidants Phase 3
4
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
5
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
6 Raspberry Approved Phase 1, Phase 2
7
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
8
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
9
Fluorouracil Approved Phase 2 51-21-8 3385
10
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
11
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
12
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
13
Nimotuzumab Investigational Phase 2 780758-10-3, 828933-61-3
14 Antirheumatic Agents Phase 2
15 Anti-Inflammatory Agents Phase 2
16 Anti-Inflammatory Agents, Non-Steroidal Phase 2
17 Cyclooxygenase Inhibitors Phase 2
18 Cyclooxygenase 2 Inhibitors Phase 2
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
22 Albumin-Bound Paclitaxel Phase 2
23 Antineoplastic Agents, Immunological Phase 2
24 Immunoglobulins Phase 2
25 Antibodies Phase 2
26 Antibodies, Monoclonal Phase 2
27 Pharmaceutical Solutions Phase 1, Phase 2
28 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
29 Tubulin Modulators Phase 2
30 Antimitotic Agents Phase 2
31 Immunosuppressive Agents Phase 2
32 Immunologic Factors Phase 2
33 Antimetabolites Phase 2
34 Mitogens Phase 1
35 Protein Kinase Inhibitors Phase 1
36
Apatinib Phase 1 811803-05-1
37
carbamide peroxide Approved 124-43-6
38
Phenol Approved, Experimental Early Phase 1 108-95-2 996
39
Licorice Approved Early Phase 1
40 Anti-Bacterial Agents Early Phase 1
41 Antimalarials Early Phase 1
42 Antiviral Agents Early Phase 1
43 Omega 3 Fatty Acid
44 Tolonium Chloride
45 Complement System Proteins
46 Anti-Infective Agents
47
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Adjuvant Radiotherapy in Patients With Oropharyngeal and Floor of Mouth Squamous Cell Carcinoma and Concomitant Histological Verification of Singular Ipsilateral Cervical Lymph Node Metastasis (pN1-state) Unknown status NCT00964977 Phase 3
2 Effect of Melatonin in Combination With Neoadjuvant Chemotherapy to HIF-1⍺, CD44, CD133, and miR-210 Expression and Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT04137627 Phase 3 Melatonin 20 MG Oral Capsule;Placebo oral capsule
3 Study of TPF (Docetaxel, Cisplatin, 5-fluorouracil) Induction Chemotherapy Followed by Surgery and Radiotherapy in Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
4 Development of Novel Diagnostic Tools and Therapeutic Strategies for Oral Cancer Unknown status NCT02739204 Phase 2 Celecoxib
5 Effect of COX-2 (Cyclooxygenase-2) and EGFR (Epidermal Growth Factor Receptor) Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study. Unknown status NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
6 A Phase II Study of Neoadjuvant Bio-chemotherapy With Cetuximab, Paclitaxel, and Cisplatin (CPC) Followed by Cetuximab-based Concurrent Bio-radiotherapy in High-risk Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
7 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed NCT01192204 Phase 1, Phase 2 10% FBR containing bioadhesive gel;placebo gel
8 Phase 1/2, Open-Label, Single-Arm Safety and Efficacy Dose-Finding, Systemic Exposure, and Device Technical Effects of PRV111 (Cisplatin Transmucosal System) in Subjects With Oral Squamous Cell Carcinoma Recruiting NCT03502148 Phase 1, Phase 2 PRV111 (Cisplatin Transmucosal System)
9 A Phase II, Prospective, Single-center, Randomized, Controlled Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squamous Cell Carcinoma Recruiting NCT04367909 Phase 2 Nimotuzumab;Docetaxel;Carboplatin
10 Phase II Trial of Sintilimab, an Anti-PD-1 Monoclonal Antibody, in Combination With Carboplatin and Nab-paclitaxel , as a Novel Neoadjuvant Pre-Surgical Therapy for Oral Cavity Squamous Cell Carcinoma . Recruiting NCT04718415 Phase 2 sintilimab, paclitaxel, carboplatin
11 A Phase I/II Study of the Fluorescent PARP1 Binding Imaging Agent PARPi-FL in Patients With Oral Squamous Cell Carcinomas Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
12 Cyclin D1 Based TPF(Docetaxel, Cisplatin and 5-fluorouracil) Induction Chemotherapy for OSCC(Oral Squamous Cell Carcinoma) Patients at cN2(Clinical Node 2) Stage: a Phase II Randomized Controlled Trial Recruiting NCT02290145 Phase 2 TPF group
13 A Randomized Phase II Trial of TPF Induction Chemotherapy in cN2 Patients With Oral Squamous Cell Carcinoma Recruiting NCT02285543 Phase 2 TPF induction chemotherapy
14 GDF15 (Growth Differentiation Factor 15) Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at T3/T4cN0M0 Stage: a Phase II Randomized Controlled Trial Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
15 A Randomized Phase II Study of Neoadjuvant PD-1 Blockade Alone or Plus TPF Induction Chemotherapy for Resectable Local Advanced Oral Squamous Cell Carcinoma Not yet recruiting NCT04649476 Phase 2 Camrelizumab;Camrelizumanb plus TPF
16 Phase I Trial Of Intratumoral EGFR Antisense DNA And DC-Chol Liposomes In Advanced Oral Squamous Cell Carcinoma Completed NCT00009841 Phase 1 DC-cholesterol liposome
17 Safety and Efficacy Evaluation of Carrimycin in Patients With Locally Advanced, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma (Non NPC): A Phase I Trial Recruiting NCT04413214 Phase 1 Carrimycin
18 Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma: A Single-arm Phase I Trial Recruiting NCT04393506 Phase 1 Camrelizumab;Apatinib
19 Inductive Toripalimab and Paclitaxel/Cisplatin on Pathological Response in Oral Squamous Cell Carcinoma Patients: A Single-arm Phase I Trial Recruiting NCT04473716 Phase 1 Toripalimab;Paclitaxcel;Cisplatin
20 Pivotal Validation Study of Salivary Biomarkers for the Risk Stratification of Patients With Lesions Suspicious for Oral Squamous Cell Carcinoma Unknown status NCT01587573
21 Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line Unknown status NCT03619304
22 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
23 A Randomized, Double Blind, Controlled, Multi-center, Phase III Study to Assess Efficacy of Low Level Diode Laser (100 MW, 658 Nm), in the Prevention and Treatment of Radiochemotherapy-induced Mucositis in Head and Neck Cancer. Unknown status NCT01772706
24 Validation of Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Unknown status NCT03345966
25 SEND Trial The Role of Selective Neck Dissection Used Electively in Patients With Early Oral Squamous Cell Carcinoma (1-3cm Primary Size) and No Clinical Evidence of Lymph Node Metastases in the Neck Unknown status NCT00571883
26 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
27 Apoptotic and Anti-Proliferative Effects of Licorice Extract (Licochalcone A) and Paclitaxel Chemotherapy on Human Oral Squamous Cell Carcinoma Cell Line Unknown status NCT03292822 Early Phase 1 Paclitaxel
28 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
29 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
30 A Cohort Study on Prediction of Malignant Transformation of Oral Epithelial Dysplasia by p16 Methylation Completed NCT00835341
31 A Phase 1b Pilot Study Evaluating Oral Administration of Freeze-Dried Black Raspberries in Pre-Surgical Patients With Oral Squamous Cell Carcinoma Completed NCT01465776
32 A Double Blind, Randomised, Placebo Controlled, Feasibility Phase III Clinical Trial of Peri-operative Immune-enhancing Feed in Patients Undergoing Surgery for Advanced Head and Neck Cancer Completed NCT01314755
33 Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma Completed NCT03554967
34 Fluorescent Visualization in Early Oral Cancer Completed NCT02306967
35 Etude de Concordance Entre la Technique OSNA et Les Techniques Classiques Pour la Recherche de métastases Ganglionnaires Des Cancers Des VADS Completed NCT02852343
36 Modern Hybrid Imaging for Staging and Monitoring Patients With Oral Squamous Cell Carcinoma Completed NCT04280159
37 Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma? Completed NCT00693550
38 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma. Completed NCT02323672
39 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma. (Retrospective-cohort Study) Completed NCT03109457
40 Using Maackia Amurensis Seed Lectin to Target the Podoplanin Receptor as a Functionally Relevant Biomarker to Inhibit the Growth of Oral Squamous Cell Carcinoma and Precancerous Lesions Recruiting NCT04188665 Early Phase 1 MASL
41 Survival Benefit of Elective Neck Dissection for Patients With T1,2N0M0 Oral Squamous Cell Carcinoma-A Prospective Multicenter Randomized Controlled Study Recruiting NCT01334320
42 Prospective Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore Recruiting NCT03975322
43 A Randomized,Multicenter,Prospectie,Controlled Clinical Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. Recruiting NCT02743832
44 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Recruiting NCT03418454
45 Predicting Metastatic Oral Squamous Cell Carcinomas With Molecular Biomarkers Using Machine Learning Recruiting NCT04543266
46 Submandibular Gland Preservation During Neck Dissection for Oral Squamous Cell Carcinoma Recruiting NCT03385720
47 An Evaluation of the Radio/Pathological Correlation of Depth Of Invasion for Oral Squamous Cell Carcinoma, a Retrospective Study in a University Hospital in Lyon Recruiting NCT04821128
48 Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma Recruiting NCT03877159
49 Myeloid-derived Suppressor Cells (MDSCs) Detection Before and After Beta-glucan Administration in Oral Squamous Cell Carcinoma Patients Active, not recruiting NCT04387682
50 Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population Not yet recruiting NCT04270201

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

40
Lymph Node, Tongue, Endothelial, Myeloid, T Cells, Neutrophil, Skin

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 10445)
# Title Authors PMID Year
1
Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. 61 47
19396866 2009
2
The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. 47 61
19435529 2009
3
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. 61 47
18381414 2008
4
Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. 47
18946016 2008
5
MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A. 61
33724144 2021
6
Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma. 61
33511313 2021
7
Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis. 61
33786612 2021
8
SATB2 overexpression promotes oral squamous cell carcinoma progression by up-regulating NOX4. 61
33675939 2021
9
Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. 61
33578238 2021
10
OSCC cell-secreted exosomal CMTM6 induced M2-like macrophages polarization via ERK1/2 signaling pathway. 61
33104837 2021
11
Clinical characteristics, treatment intent, and outcome in a consecutive 10-year cohort of oral cancer patients aged 75 years and older. 61
33261937 2021
12
Cancer-derived IgG involved in cisplatin resistance through PTP-BAS/Src/PDK1/AKT signaling pathway. 61
32730654 2021
13
Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk. 61
33548289 2021
14
Multiple Tumour Recurrence in Oral, Head and Neck Cancer: Characterising The Patient Journey. 61
33811374 2021
15
Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims. 61
33532199 2021
16
Lymph node ratio as a predictor for outcome in oral squamous cell carcinoma: a multicenter population-based cohort study. 61
32754787 2021
17
Semaphorin 4A restricts tumor progression by inhibiting angiogenesis of oral squamous cell carcinoma cells. 61
33460983 2021
18
Long non-coding RNA OIP5-AS1 contributes to cisplatin resistance of oral squamous cell carcinoma through the miR-27b-3p/TRIM14 axis. 61
33692839 2021
19
Metastasis of oral squamous cell carcinoma to the parotid lymph nodes. 61
32747220 2021
20
Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. 61
33692871 2021
21
Epithelial-to-mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities. 61
33091960 2021
22
Pattern of tumor invasion, stromal inflammation, angiogenesis and vascular invasion in oral squamous cell carcinoma - A prognostic study. 61
32893000 2021
23
Microtubule-targeting agents impair kinesin-2-dependent nuclear transport of β-catenin: Evidence of inhibition of Wnt/β-catenin signaling as an important antitumor mechanism of microtubule-targeting agents. 61
33742719 2021
24
Development of lung metastases in mouse models of tongue squamous cell carcinoma. 61
32767730 2021
25
miR-188-5p inhibits proliferation, migration, and invasion in gallbladder carcinoma by targeting Wnt2b and Smad2. 61
33236530 2021
26
Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes. 61
33089709 2021
27
Oral submucous fibrosis transforming into squamous cell carcinoma: a prospective study over 31 years in mainland China. 61
32844258 2021
28
TRIB3 promotes oral squamous cell carcinoma cell proliferation by activating the AKT signaling pathway. 61
33717256 2021
29
Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma. 61
33352248 2021
30
Clinicopathologic Characteristics of Young Patients with Oral Squamous Cell Carcinoma. 61
33797696 2021
31
Body mass index and self-care behaviors related to oral health-related quality of life in patients with oral squamous cell carcinoma within three months posttreatment. 61
32910290 2021
32
Research on neck dissection for oral squamous-cell carcinoma: a bibliometric analysis. 61
33795644 2021
33
Identification and characterization of R2TP in the development of oral squamous cell carcinoma. 61
33640610 2021
34
Automatic detection of cervical lymph nodes in patients with oral squamous cell carcinoma using a deep learning technique: a preliminary study. 61
32506212 2021
35
lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR-375/JAK2 axis. 61
33732364 2021
36
Effects of photobiomodulation on cellular viability and cancer stem cell phenotype in oral squamous cell carcinoma. 61
32813258 2021
37
Knockdown of RABL3 suppresses the proliferation and invasion of oral squamous cell carcinoma through inactivating the FAK/AKT pathway. 61
33438143 2021
38
Long non-coding RNA LINC01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p. 61
33797737 2021
39
Exposure to chewing tobacco promotes primary oral squamous cell carcinoma and regional lymph node metastasis by alterations of SDF1α/CXCR4 axis. 61
33655604 2021
40
Real-time loop-mediated isothermal amplification assay for rapid detection of human papillomavirus 16 in oral squamous cell carcinoma. 61
33581498 2021
41
Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma. 61
32688445 2021
42
Comparison of Early Oral Cancer Depth of Invasion From the American Joint Committe on Cancer 7th to 8th Edition Criteria. Does the Difference Impact the Accuracy of Clinical Decision Making? 61
33171115 2021
43
Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway. 61
33762576 2021
44
Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. 61
33723306 2021
45
How is neck dissection performed in Oral and Maxillofacial Surgery? Results of a representative nationwide survey among university and non-university hospitals in Germany. 61
33779814 2021
46
4sc-202 and Ink-128 cooperate to reverse the epithelial to mesenchymal transition in OSCC. 61
33772986 2021
47
Particle size penetration rate and effects of smoke and smokeless tobacco products - An invitro analysis. 61
33768172 2021
48
Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis. 61
33681421 2021
49
MICA A5.1 homozygous genotype is associated with a risk for early-onset oral cancer. 61
33730629 2021
50
Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models. 61
33806894 2021

Variations for Oral Squamous Cell Carcinoma

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification CTTN Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification LTO1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification LTO1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 UCA1 MEG3 HOTAIR

GO Terms for Oral Squamous Cell Carcinoma

Cellular components related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.8 MIR21 MIR193A MIR100

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.43 MIR21 MIR193A MIR137
2 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 MIR21 H19
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.33 MIR21 MIR193A MIR137
4 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.32 MIR21 MIR137
5 gene silencing by miRNA GO:0035195 9.17 NEAT1 MIR21 MIR193A MIR137 MIR100 MEG3
6 negative regulation of superoxide dismutase activity GO:1901670 8.96 MIR21 H19

Molecular functions related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.92 MIR21 MIR193A MIR137 MIR100

Sources for Oral Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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