MCID: ORL015
MIFTS: 45

Oral Squamous Cell Carcinoma

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 76 53 15
Squamous Cell Carcinoma of Mouth 73
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 73 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and melanoma. An important gene associated with Oral Squamous Cell Carcinoma is MIR21 (MicroRNA 21
This study investigated the pathogenetic implications of miR-211 in oral carcinogenesis. An association was found between higher miR-211 expression and the most advanced nodal metastasis, vascular invasion, and poor prognosis of oral carcinoma. The function of enforced miR-211 expression in oral carcinoma cells was confirmed by the repression of LacZ in a reporter plasmid via miR-211 targeting. Enforced miR-211 expression significantly increased the proliferation, migration, and anchorage-independent colony formation of oral carcinoma cells, while it enhanced the tumorigenicity of only SAS high-grade oral carcinoma cells, but not OECM-1 non-tumorigenic cells. The findings suggest that high miR-211 expression may be associated with the progression of oral carcinoma and poor patient outcomes.), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and skin.

Wikipedia : 76 Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 33.6 CCAT2 FOXCUT HOTAIR MALAT1 NEAT1 TUG1
2 melanoma 31.5 HOTAIR MALAT1 MEG3 MIR100 MIR137 MIR193A
3 esophageal cancer 31.2 CCAT1 HOTAIR MALAT1 MEG3 MIR21 UCA1
4 retinoblastoma 30.9 CCAT1 HOTAIR MALAT1 MEG3
5 pancreatic ductal adenocarcinoma 11.2 HOTAIR MALAT1 MIR21 UCA1
6 functionless pituitary adenoma 11.2 HOTAIR MEG3
7 esophagus squamous cell carcinoma 11.2 HOTAIR MEG3 TUG1
8 triple-receptor negative breast cancer 11.2 HOTAIR MALAT1
9 small cell cancer of the lung 11.2 CCAT2 HOTAIR MALAT1 MIR21 TUG1
10 kidney cancer 11.1 HOTAIR MALAT1 MEG3 MIR21
11 pituitary adenoma 11.1 CCAT2 HOTAIR MALAT1 MEG3
12 tongue squamous cell carcinoma 11.1 MALAT1 MEG3 MIR21 UCA1
13 clear cell renal cell carcinoma 11.1 CCAT2 MALAT1 MEG3 MIR21 TUG1
14 ovarian serous carcinoma 11.1 MIR100 MIR21
15 bladder urothelial carcinoma 11.1 HOTAIR MALAT1 MEG3 TUG1
16 cholangiocarcinoma 11.0 CCAT2 MALAT1 MIR21 NEAT1 TUG1 UCA1
17 gallbladder cancer 11.0 CCAT1 HOTAIR MALAT1 MEG3 TUG1 UCA1
18 renal cell carcinoma, nonpapillary 11.0 CCAT1 HOTAIR MALAT1 TUG1 UCA1
19 glioblastoma 11.0 HOTAIR MALAT1 MEG3 MIR137 MIR21 TUG1
20 myeloma, multiple 11.0 CCAT1 HOTAIR MALAT1 MEG3 TUG1 UCA1
21 prostate disease 11.0 MALAT1 MEG3
22 astrocytoma 11.0 HOTAIR MIR21 NEAT1 SOX21-AS1
23 intrahepatic cholangiocarcinoma 11.0 CCAT1 CCAT2 TUG1
24 gastric cardia adenocarcinoma 11.0 HOTAIR MEG3
25 leukemia, acute myeloid 11.0 CCAT1 HOTAIR MALAT1 MEG3 MIR21 TUG1
26 thyroid cancer, nonmedullary, 1 11.0 HOTAIR MALAT1 MEG3 MIR193A MIR21 NEAT1
27 lung cancer susceptibility 3 11.0 CCAT1 HOTAIR MALAT1 MEG3 TUG1
28 ovarian epithelial cancer 11.0 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR100
29 vulva squamous cell carcinoma 10.9 MALAT1 MEG3
30 bladder cancer 10.9 CCAT2 HOTAIR MALAT1 MEG3 MIR100 MIR21
31 lung squamous cell carcinoma 10.9 CCAT1 CCAT2 MEG3 TUG1
32 liver cirrhosis 10.9 HOTAIR MALAT1 MEG3
33 osteogenic sarcoma 10.8 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 NEAT1
34 glioma 10.8 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR21
35 malignant glioma 10.8 MALAT1 MEG3
36 adamantinoma of long bones 10.8 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 NEAT1
37 nasopharyngeal carcinoma 10.8 CCAT1 FOXCUT HOTAIR MALAT1 MEG3 MIR100
38 cervical cancer 10.8 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR21
39 endometrial cancer 10.8 CCAT1 HOTAIR MEG3 NEAT1 TUG1 UCA1
40 pancreatic cancer 10.8 CCAT1 HOTAIR MALAT1 MEG3 MIR100 MIR21
41 prostate cancer 10.7 CCAT2 HOTAIR MALAT1 MEG3 MIR100 MIR21
42 hepatocellular carcinoma 10.7 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR137
43 ovarian cancer 10.7 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR100
44 b-cell lymphomas 10.7 HOTAIR MALAT1 TUG1
45 thyroid cancer 10.7 HOTAIR MALAT1 NEAT1 UCA1
46 leukoplakia 10.6
47 gastric cancer 10.6 CCAT1 CCAT2 CEBPA-DT HOTAIR LINC00668 MALAT1
48 endotheliitis 10.6
49 oral leukoplakia 10.6
50 lung cancer 10.6 CCAT1 CCAT2 HOTAIR MALAT1 MEG3 MIR100

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
2
Docetaxel Approved, Investigational Phase 2, Phase 3 114977-28-5 148124
3
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
4 Antimetabolites Phase 2, Phase 3
5 Antimetabolites, Antineoplastic Phase 2, Phase 3
6 Antimitotic Agents Phase 2, Phase 3,Early Phase 1
7 Immunosuppressive Agents Phase 2, Phase 3
8
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
9
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
10
Paclitaxel Approved, Vet_approved Phase 2,Early Phase 1 33069-62-4 36314
11
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
12 Raspberry Approved, Nutraceutical Phase 1, Phase 2,Not Applicable
13 Analgesics Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Anti-Inflammatory Agents Phase 2
16 Anti-Inflammatory Agents, Non-Steroidal Phase 2
17 Antirheumatic Agents Phase 2
18 Cyclooxygenase 2 Inhibitors Phase 2
19 Cyclooxygenase Inhibitors Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Mitogens Phase 2,Phase 1
22 Albumin-Bound Paclitaxel Phase 2,Early Phase 1
23 Antineoplastic Agents, Phytogenic Phase 2,Early Phase 1
24 Antioxidants Phase 2
25 Protective Agents Phase 2
26 Pharmaceutical Solutions Phase 1, Phase 2
27 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
28
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
29 Protein Kinase Inhibitors Phase 2
30
Ethanol Approved Not Applicable 64-17-5 702
31
Phenol Approved, Experimental Early Phase 1 108-95-2 996
32 Licorice Approved, Nutraceutical Early Phase 1
33 Lugol's solution Not Applicable
34 Antibodies ,Not Applicable
35 Antibodies, Monoclonal
36 Immunoglobulins ,Not Applicable
37 Anti-Bacterial Agents Early Phase 1
38 Antimalarials Early Phase 1
39 Antiviral Agents Early Phase 1

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL Unknown status NCT01039298 Phase 3
2 TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
3 Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer Recruiting NCT01772706 Phase 3
4 Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma Unknown status NCT02739204 Phase 2 Celecoxib
5 A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
6 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
7 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed NCT01192204 Phase 1, Phase 2 10% FBR containing bioadhesive gel;placebo gel
8 Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma Recruiting NCT03502148 Phase 1, Phase 2 PRV111 (Cisplatin Transmucosal System)
9 A Dye for the Detection of Cancer of the Tongue and Mouth Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
10 Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage Recruiting NCT02290145 Phase 2 TPF group
11 GDF15 Based TPF Induction Chemotherapy for OSCC Patients Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
12 Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study Recruiting NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
13 A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients Active, not recruiting NCT02285543 Phase 2 TPF induction chemotherapy
14 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
15 Gene Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00009841 Phase 1 DC-cholesterol liposome
16 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
17 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
18 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
19 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
20 One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma Unknown status NCT02852343
21 Neck Surgery in Treating Patients With Early-Stage Oral Cancer Unknown status NCT00571883 Not Applicable
22 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable
23 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544 Not Applicable
24 The Functional and Clinicopathological Roles and Therapeutic Implication of Connective Tissue Growth Factor in Peritoneal Metastasis of Gastric Cancer Unknown status NCT01627119
25 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
26 Epstein-Barr Detection in Oral Cancer Completed NCT01039272
27 Fluorescent Visualization in Early Oral Cancer Completed NCT02306967 Not Applicable
28 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
29 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
30 Freeze-Dried Black Raspberries in Treating Patients With Oral Squamous Cell Cancer Undergoing Surgery Completed NCT01465776 Not Applicable
31 Human Papillomavirus on Oral Tissue, Saliva and Serum Completed NCT01043328
32 Autofluorescence for the Screening of Precancerous and Malignant Lesions Completed NCT01167790 Not Applicable
33 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia Completed NCT00835341
34 Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma Recruiting NCT01334320 Not Applicable
35 A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. Recruiting NCT02743832 Not Applicable
36 Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer Recruiting NCT01587573
37 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Recruiting NCT03418454
38 Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors Recruiting NCT02975739 Early Phase 1
39 Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer Recruiting NCT00899704
40 Submandibular Gland Preservation in Neck Dissection Active, not recruiting NCT03385720 Not Applicable
41 Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer Active, not recruiting NCT03053960
42 Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients Active, not recruiting NCT03529604
43 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma Not yet recruiting NCT03109457
44 Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma Not yet recruiting NCT03554967
45 Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Not yet recruiting NCT03345966 Not Applicable
46 Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03292822 Early Phase 1 Paclitaxel

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

41
Lymph Node, Endothelial, Skin, Bone, Tongue, T Cells, Testes

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 2302)
# Title Authors Year
1
XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. ( 29916547 )
2018
2
Serum bilirubin level predicts post-operative overall survival in oral squamous cell carcinoma. ( 29430757 )
2018
3
CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma. ( 29360827 )
2018
4
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. ( 29464350 )
2018
5
TGF-I^1/TI^RII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages. ( 29462614 )
2018
6
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma. ( 29491060 )
2018
7
Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma. ( 29900911 )
2018
8
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors. ( 29963189 )
2018
9
Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma. ( 29620248 )
2018
10
Human Papilloma Virus 16/18: Fabricator of Trouble in Oral Squamous Cell Carcinoma. ( 29432879 )
2018
11
Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator. ( 29422466 )
2018
12
CD47 as a potential prognostic marker for oral leukoplakia and oral squamous cell carcinoma. ( 29805639 )
2018
13
Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids. ( 29435298 )
2018
14
Oral squamous cell carcinoma profile in North-Eastern regions of India from habits to histopathology: A hospital-based study. ( 29937660 )
2018
15
[Corrigendum] Long nona89coding RNAA H19 promotes cell proliferation and invasion by acting as a ceRNA of miRa89138 and releasing EZH2 in oral squamous cell carcinoma. ( 29901192 )
2018
16
Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line. ( 29435078 )
2018
17
Meta-analysis of the prognostic value of the neutrophil-to-lymphocyte ratio in oral squamous cell carcinoma. ( 29406591 )
2018
18
Frequency of circulating CD14<sup>++</sup> CD16<sup>+</sup> intermediate monocytes as potential biomarker for the diagnosis of oral squamous cell carcinoma. ( 29961993 )
2018
19
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. ( 29911943 )
2018
20
Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With Histologic Risk Factors: Are We Over-Treating? ( 29438656 )
2018
21
MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. ( 29407635 )
2018
22
PDGFRI+/HER2 and PDGFRI+/p53 Co-expression in Oral Squamous Cell Carcinoma. ( 29374704 )
2018
23
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry ( 29699065 )
2018
24
Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. ( 29423682 )
2018
25
Tumor budding is associated with poor prognosis of oral squamous cell carcinoma and histologically represents an epithelial-mesenchymal transition process. ( 29936060 )
2018
26
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. ( 29970504 )
2018
27
Immunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma. ( 29964301 )
2018
28
The possible contemporary presence of BRONJ and oral squamous cell carcinoma. ( 29941328 )
2018
29
miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling. ( 29364705 )
2018
30
Dermoscopy Of Oral Squamous Cell Carcinoma. ( 29938447 )
2018
31
Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. ( 29433680 )
2018
32
Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis. ( 29652009 )
2018
33
Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature. ( 29433990 )
2018
34
DDR2 overexpression in oral squamous cell carcinoma is associated to lymph node metastasis. ( 29945346 )
2018
35
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
36
Sequential injection of radioactive nanosized colloids followed by indocyanine green for sentinel lymph node detection in oral squamous cell carcinoma: A proof of concept. ( 29429631 )
2018
37
Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma. ( 29171106 )
2018
38
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma. ( 29416107 )
2018
39
A Noninvasive Test for MicroRNA Expression in Oral Squamous Cell Carcinoma. ( 29914173 )
2018
40
Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. ( 29444110 )
2018
41
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. ( 29074611 )
2018
42
Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factora89related apoptosisa89inducing liganda89induced oral squamous cell carcinoma apoptosis and suppresses proliferation inA vitro and inA vivo. ( 29901096 )
2018
43
Comparison of the expression of TGF-I^1, E-cadherin, N-cadherin, TP53, RB1CC1 and HIF-1I+ in oral squamous cell carcinoma and lymph node metastases of humans and mice. ( 29399192 )
2018
44
A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma. ( 29423024 )
2018
45
SCCA, TSGF, and the Long Non-Coding RNA AC007271.3 are Effective Biomarkers for Diagnosing Oral Squamous Cell Carcinoma. ( 29763905 )
2018
46
Tissue and serum expression of TGM-3 may be prognostic marker in patients of oral squamous cell carcinoma undergoing chemo-radiotherapy. ( 29953521 )
2018
47
Nitidine chloride represses Mcl-1 protein via lysosomal degradation in oral squamous cell carcinoma. ( 29924888 )
2018
48
Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients. ( 29937653 )
2018
49
Mecambridine induces potent cytotoxic effects, autophagic cell death and modulation of the mTOR/PI3K/Akt signaling pathway in HSC-3 oral squamous cell carcinoma cells. ( 29422960 )
2018
50
Co-expression analysis reveals key gene modules and pathways of oral squamous cell carcinoma. ( 29914011 )
2018

Variations for Oral Squamous Cell Carcinoma

Cosmic variations for Oral Squamous Cell Carcinoma:

9
(show top 50) (show all 1404)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM3724309 ZNF536 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1935G>C p.Q645H 19:30445497-30445497 16
2 COSM6976115 YES1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1288C>T p.Q430* 18:736811-736811 16
3 COSM6914703 XPO1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.619C>G p.Q207E 2:61498885-61498885 16
4 COSM6957917 TSC2 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 16
5 COSM121050 TP63 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.551C>T p.S184L 3:189808498-189808498 16
6 COSM10645 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 16
7 COSM69404 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 16
8 COSM43708 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 16
9 COSM11073 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 16
10 COSM43947 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 16
11 COSM10660 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 16
12 COSM45607 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.676G>A p.G226S 17:7674287-7674287 16
13 COSM43592 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.395A>T p.K132M 17:7675217-7675217 16
14 COSM45794 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.421T>G p.C141G 17:7675191-7675191 16
15 COSM43850 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 16
16 COSM43606 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.734G>A p.G245D 17:7674229-7674229 16
17 COSM10958 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>T p.G266V 17:7673823-7673823 16
18 COSM43833 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 16
19 COSM10648 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 16
20 COSM11354 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.991C>T p.Q331* 17:7673537-7673537 16
21 COSM10786 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.949C>T p.Q317* 17:7673579-7673579 16
22 COSM10943 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.841G>C p.D281H 17:7673779-7673779 16
23 COSM10654 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 16
24 COSM44351 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 16
25 COSM11084 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>A p.V173M 17:7675095-7675095 16
26 COSM43665 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.746G>C p.R249T 17:7674217-7674217 16
27 COSM10756 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.827C>T p.A276V 17:7673793-7673793 16
28 COSM10663 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 16
29 COSM10659 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 16
30 COSM43695 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 16
31 COSM44229 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.515T>A p.V172D 17:7675097-7675097 16
32 COSM10758 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 16
33 COSM44633 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.583A>T p.I195F 17:7674948-7674948 16
34 COSM10725 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.701A>G p.Y234C 17:7674262-7674262 16
35 COSM10771 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 16
36 COSM10939 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 16
37 COSM45353 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.673G>A p.V225I 17:7674290-7674290 16
38 COSM10704 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 16
39 COSM44935 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.724T>A p.C242S 17:7674239-7674239 16
40 COSM43714 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 16
41 COSM10646 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>A p.C242Y 17:7674238-7674238 16
42 COSM43743 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.914A>G p.K305R 17:7673706-7673706 16
43 COSM10905 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 16
44 COSM10656 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 16
45 COSM10735 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 16
46 COSM10662 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 16
47 COSM44823 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.981T>G p.Y327* 17:7673547-7673547 16
48 COSM43906 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.843C>A p.D281E 17:7673777-7673777 16
49 COSM10724 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 16
50 COSM43680 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 16

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification EMS1 Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification TAOS1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification ORAOV1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 HOTAIR MEG3 UCA1

GO Terms for Oral Squamous Cell Carcinoma

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood vessel endothelial cell migration GO:0043537 9.26 MIR137 MIR193A
2 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.16 MIR137 MIR21
3 negative regulation of angiogenesis GO:0016525 9.13 MIR137 MIR193A MIR21
4 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.8 MIR137 MIR193A MIR21

Molecular functions related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.8 MIR137 MIR193A MIR21

Sources for Oral Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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