MCID: ORL015
MIFTS: 43

Oral Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 74 52 15 17
Squamous Cell Carcinoma of Mouth 71
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 71 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and tongue squamous cell carcinoma. An important gene associated with Oral Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Melatonin and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, tongue and bone.

Wikipedia : 74 Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 33.6 UCA1 TUG1 NEAT1 MALAT1 HOTAIR H19
2 tongue squamous cell carcinoma 32.0 UCA1 MIR21 MEG3 MALAT1
3 b-cell lymphoma 31.6 TUG1 MIR21 MALAT1 HOTAIR
4 melanoma 31.4 UCA1 MIR193A MIR137 MIR100 MEG3 MALAT1
5 esophageal cancer 31.3 UCA1 MIR21 MIR193A MIR100 MEG3 MALAT1
6 bladder cancer 31.2 UCA1 TUG1 MIR21 MIR193A MIR100 MEG3
7 lung cancer susceptibility 3 31.2 TUG1 MIR21 MIR193A MEG3 MALAT1 HOTAIR
8 colorectal cancer 31.2 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
9 pancreatic ductal adenocarcinoma 31.1 UCA1 MIR21 MALAT1 HOTAIR H19
10 hepatocellular carcinoma 31.1 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
11 nasopharyngeal carcinoma 31.0 NEAT1 MIR21 MIR100 MEG3 MALAT1 HOTAIR
12 osteogenic sarcoma 31.0 UCA1 TUG1 NEAT1 MEG3 MALAT1 HOTAIR
13 ovarian cancer 30.9 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR100
14 prostate cancer 30.9 UCA1 TUG1 NEAT1 MIR21 MIR100 MEG3
15 thyroid cancer, nonmedullary, 1 30.9 MALAT1 HOTAIR H19
16 gastric cancer 30.9 UCA1 TUG1 NEAT1 MIR21 MEG3 MALAT1
17 laryngeal squamous cell carcinoma 30.8 NEAT1 MIR21 MALAT1 HOTAIR H19 CCAT1
18 kidney cancer 30.8 MIR21 MEG3 MALAT1 HOTAIR H19
19 pancreatic cancer 30.8 UCA1 TUG1 NEAT1 MIR21 MIR100 MEG3
20 myeloma, multiple 30.8 UCA1 TUG1 MIR21 MEG3 MALAT1 HOTAIR
21 gallbladder cancer 30.8 UCA1 TUG1 MEG3 MALAT1 HOTAIR H19
22 glioma 30.8 UCA1 NEAT1 MIR21 MEG3 MALAT1 HOTAIR
23 cervical cancer 30.7 UCA1 TUG1 NEAT1 MIR21 MEG3 MALAT1
24 leukemia, acute myeloid 30.7 UCA1 TUG1 MIR21 MIR193A MEG3 MALAT1
25 lung cancer 30.7 UCA1 TUG1 NEAT1 MIR21 MIR193A MIR137
26 endometrial cancer 30.7 UCA1 TUG1 NEAT1 MEG3 HOTAIR H19
27 pre-eclampsia 30.5 TUG1 MALAT1 HOTAIR H19
28 lung squamous cell carcinoma 30.5 TUG1 MEG3 CCAT2 CCAT1
29 meningioma, radiation-induced 30.1 MEG3 H19
30 oral cancer 11.4
31 leukoplakia 11.0
32 oral leukoplakia 10.9
33 obsolete: squamous cell carcinoma of head and neck 10.8
34 lichen planus 10.8
35 small cell cancer of the lung 10.8 TUG1 MIR21 MALAT1 HOTAIR CCAT2
36 oral submucous fibrosis 10.8
37 oral lichen planus 10.8
38 esophagus squamous cell carcinoma 10.7 TUG1 MEG3 HOTAIR
39 glioma susceptibility 1 10.7 TUG1 MIR21 MIR137 MEG3 MALAT1 HOTAIR
40 papilloma 10.7
41 cholangiocarcinoma 10.7 UCA1 TUG1 NEAT1 MIR21 MALAT1 H19
42 squamous cell papilloma 10.7
43 astrocytoma 10.7 UCA1 NEAT1 MIR21 HOTAIR H19
44 bladder urothelial carcinoma 10.7 UCA1 TUG1 MEG3 MALAT1 HOTAIR
45 triple-receptor negative breast cancer 10.7 MALAT1 HOTAIR
46 pituitary adenoma 10.7 MEG3 MALAT1 HOTAIR H19 CCAT2
47 gastric cardia adenocarcinoma 10.7 MEG3 HOTAIR H19
48 tongue cancer 10.7
49 clear cell renal cell carcinoma 10.7 TUG1 MIR21 MEG3 MALAT1 CCAT2
50 in situ carcinoma 10.7

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Phase 3 73-31-4 896
2 Protective Agents Phase 3
3 Antioxidants Phase 3
4 Central Nervous System Depressants Phase 3
5 Raspberry Approved Phase 1, Phase 2
6
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
7
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
8
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
9
Morphine Approved, Investigational Phase 1, Phase 2 57-27-2 5288826
10
Mecasermin Approved, Investigational Phase 1, Phase 2 68562-41-4
11
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
12
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
13
Fluorouracil Approved Phase 2 51-21-8 3385
14
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
15
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 1406-16-2
16
Calcitriol Approved, Nutraceutical Phase 1, Phase 2 32222-06-3 134070 5280453
17
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
18 Omega 3 Fatty Acid Phase 2
19 Albumin-Bound Paclitaxel Phase 2
20 Vitamins Phase 1, Phase 2
21 Trace Elements Phase 1, Phase 2
22 Hormones Phase 1, Phase 2
23 Micronutrients Phase 1, Phase 2
24 Nutrients Phase 1, Phase 2
25 Vasoconstrictor Agents Phase 1, Phase 2
26 Dihydroxycholecalciferols Phase 1, Phase 2
27 Calcium, Dietary Phase 1, Phase 2
28 Calciferol Phase 1, Phase 2
29 Antibodies, Monoclonal Phase 1, Phase 2
30 Antibodies Phase 1, Phase 2
31 Immunoglobulins Phase 1, Phase 2
32 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
33 Pharmaceutical Solutions Phase 1, Phase 2
34 insulin Phase 1, Phase 2
35 Insulin, Globin Zinc Phase 1, Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Cyclooxygenase Inhibitors Phase 2
38 Anti-Inflammatory Agents, Non-Steroidal Phase 2
39 Analgesics, Non-Narcotic Phase 2
40 Antirheumatic Agents Phase 2
41 Cyclooxygenase 2 Inhibitors Phase 2
42 Analgesics Phase 2
43 Mitogens Phase 2
44 Protein Kinase Inhibitors Phase 2
45
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
46 Immunologic Factors Phase 2
47 Antimitotic Agents Phase 2
48 Immunosuppressive Agents Phase 2
49 Antimetabolites Phase 2
50
Arginine Investigational, Nutraceutical Phase 2 74-79-3 6322

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Adjuvant Radiotherapy in Patients With Oropharyngeal and Floor of Mouth Squamous Cell Carcinoma and Concomitant Histological Verification of Singular Ipsilateral Cervical Lymph Node Metastasis (pN1-state) Unknown status NCT00964977 Phase 3
2 Canadian Optically Guided Approach for Oral Lesions Surgical Trial - COOLS Unknown status NCT01039298 Phase 3
3 Study of TPF (Docetaxel, Cisplatin, 5-fluorouracil) Induction Chemotherapy Followed by Surgery and Radiotherapy in Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
4 Effect of Melatonin in Combination With Neoadjuvant Chemotherapy to HIF-1⍺, CD44, CD133, and miR-210 Expression and Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT04137627 Phase 3 Melatonin 20 MG Oral Capsule;Placebo oral capsule
5 Development of Novel Diagnostic Tools and Therapeutic Strategies for Oral Cancer Unknown status NCT02739204 Phase 2 Celecoxib
6 Cyclin D1 Based TPF(Docetaxel, Cisplatin and 5-fluorouracil) Induction Chemotherapy for OSCC(Oral Squamous Cell Carcinoma) Patients at cN2(Clinical Node 2) Stage: a Phase II Randomized Controlled Trial Unknown status NCT02290145 Phase 2 TPF group
7 A Double Blind, Randomised, Placebo Controlled, Feasibility Phase III Clinical Trial of Peri-operative Immune-enhancing Feed in Patients Undergoing Surgery for Advanced Head and Neck Cancer Completed NCT01314755 Phase 2
8 A Phase II Study of Neoadjuvant Bio-chemotherapy With Cetuximab, Paclitaxel, and Cisplatin (CPC) Followed by Cetuximab-based Concurrent Bio-radiotherapy in High-risk Locally Advanced Oral Squamous Cell Carcinoma (OSCC) Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
9 Treatment of Oral Lichen Planus Lesions Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
10 Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity Completed NCT00953849 Phase 1, Phase 2 Celecoxib;Calcitriol;Celecoxib plus Calcitriol
11 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed NCT01192204 Phase 1, Phase 2 10% FBR containing bioadhesive gel;placebo gel
12 Phase 1/2, Open-Label, Single-Arm Safety and Efficacy Dose-Finding, Systemic Exposure, and Device Technical Effects of PRV111 (Cisplatin Transmucosal System) in Subjects With Oral Squamous Cell Carcinoma Recruiting NCT03502148 Phase 1, Phase 2 PRV111 (Cisplatin Transmucosal System)
13 A Phase I/II Study of the Fluorescent PARP1 Binding Imaging Agent PARPi-FL in Patients With Oral Squamous Cell Carcinomas Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
14 GDF15 (Growth Differentiation Factor 15) Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at T3/T4cN0M0 Stage: a Phase II Randomized Controlled Trial Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
15 A Phase I/II Trial of the Insulin-Like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination With the Src Family Kinase (SFK) Inhibitor Dasatinib in Patients With Embryonal and Alveolar Rhabdomyosarcoma Recruiting NCT03041701 Phase 1, Phase 2 Dasatinib;Ganitumab
16 Randomized Placebo- Controlled Pilot Study of ZD6474 as a Chemopreventive Agent for Premalignant Lesions of the Head and Neck Active, not recruiting NCT01414426 Phase 2 vandetanib
17 A Randomized Phase II Trial of TPF Induction Chemotherapy in cN2 Patients With Oral Squamous Cell Carcinoma Active, not recruiting NCT02285543 Phase 2 TPF induction chemotherapy
18 Effect of COX-2 (Cyclooxygenase-2) and EGFR (Epidermal Growth Factor Receptor) Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study. Active, not recruiting NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
19 A Randomized Phase II Trial of Low Stathmin Expression as a Predictive Biomarker for OSCC Patients Receiving TPF Induction Chemotherapy Followed by Radical Surgery and Radiotherapy/Chemoradiotherapy Not yet recruiting NCT03326947 Phase 2 docetaxel, cisplatin and 5-fluorouracil
20 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
21 Phase I Trial Of Intratumoral EGFR Antisense DNA And DC-Chol Liposomes In Advanced Oral Squamous Cell Carcinoma Completed NCT00009841 Phase 1 DC-cholesterol liposome
22 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
23 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma. (Retrospective-cohort Study) Unknown status NCT03109457
24 Pivotal Validation Study of Salivary Biomarkers for the Risk Stratification of Patients With Lesions Suspicious for Oral Squamous Cell Carcinoma Unknown status NCT01587573
25 Validation of Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Unknown status NCT03345966
26 Apoptotic and Anti-Proliferative Effects of Licorice Extract (Licochalcone A) and Paclitaxel Chemotherapy on Human Oral Squamous Cell Carcinoma Cell Line Unknown status NCT03292822 Early Phase 1 Paclitaxel
27 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
28 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
29 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus. Diagnostic Value of White Light Endoscopy, Narrow Band Imaging and Chromoendoscopy for Detection of Esophageal Manifestation in Patients With Oral Lichen. Unknown status NCT02532166
30 SEND Trial The Role of Selective Neck Dissection Used Electively in Patients With Early Oral Squamous Cell Carcinoma (1-3cm Primary Size) and No Clinical Evidence of Lymph Node Metastases in the Neck Unknown status NCT00571883
31 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
32 The Relation of Microtubule-Associated Protein 2 and Cell Migration Unknown status NCT00174109
33 The Functional and Clinicopathological Roles and Therapeutic Implication of Connective Tissue Growth Factor in Peritoneal Metastasis of Gastric Cancer Unknown status NCT01627119
34 A Phase 1b Pilot Study Evaluating Oral Administration of Freeze-Dried Black Raspberries in Pre-Surgical Patients With Oral Squamous Cell Carcinoma Completed NCT01465776
35 Epstein-Barr Detection in Squamous Cell Carcinoma and Healthy Oral Mucosa Completed NCT01039272
36 Fluorescent Visualization in Early Oral Cancer Completed NCT02306967
37 Molecular Mechanisms of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
38 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma. Completed NCT02323672
39 A Cohort Study on Prediction of Malignant Transformation of Oral Epithelial Dysplasia by p16 Methylation Completed NCT00835341
40 Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma? Completed NCT00693550
41 Detection of Salivary 8-Hydroxy-2-Deoxyguanosine and Total Antioxidant Capacity in Patients With Oral Premalignant and Malignant Lesions Completed NCT03830710
42 Assessing Efficacy of Neoadjuvant Chemoradiotherapy as a Treatment Plan for Patients With Stage IVa Oral Cancer. Completed NCT03923998 Early Phase 1 Neoadjuvant chemotherapy
43 Interest of Oral Tissue Autofluorescence for the Screening of Precancerous Lesions and Cancer in Population With Tobacco and Alcohol Abuse. Completed NCT01167790
44 Comparison of Detection of Human Papillomavirus on Tissue, Saliva and Serum Completed NCT01043328
45 Real-time Semi-quantification of Endoscopic Ultrasound Elastography and Contrast-enhancement Using Strain Histograms (SH) and Contrast-enhancement (CE) for the Differentiation of Focal Pancreatic Masses and the Assessment of Lymph Node Involvement Completed NCT02459041
46 A Randomized,Multicenter,Prospectie,Controlled Clinical Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. Recruiting NCT02743832
47 Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma Recruiting NCT03554967
48 Survival Benefit of Elective Neck Dissection for Patients With T1,2N0M0 Oral Squamous Cell Carcinoma—A Prospective Multicenter Randomized Controlled Study Recruiting NCT01334320
49 Multispectral Optoacoustic Imaging Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases: a Single Center Proof of Concept Study Recruiting NCT03923881
50 Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma Recruiting NCT03877159

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

40
Lymph Node, Tongue, Bone, Endothelial, T Cells, Skin, Lung

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 9128)
# Title Authors PMID Year
1
Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. 61 46
19396866 2009
2
The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. 61 46
19435529 2009
3
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. 61 46
18381414 2008
4
Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. 46
18946016 2008
5
R2TP/PAQosome as a promising chemotherapeutic target in cancer. 61
31890057 2020
6
MiR-132 inhibits migration and invasion and increases chemosensitivity of cisplatin-resistant oral squamous cell carcinoma cells via targeting TGF-β1. 61
31906769 2020
7
Histopathological imaging database for oral cancer analysis. 61
32021884 2020
8
Identification of a six-gene prognostic signature for oral squamous cell carcinoma. 61
31538341 2020
9
An immuno-MALDI mass spectrometry assay for the oral cancer biomarker, matrix metalloproteinase-1, in dried saliva spot samples. 61
31987131 2020
10
Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4. 61
31970286 2020
11
The balance of serum IL-18/IL-37 levels is disrupted during the development of oral squamous cell carcinoma. 61
31983439 2020
12
Small nucleolar RNA host gene 3 facilitates cell proliferation and migration in oral squamous cell carcinoma via targeting nuclear transcription factor Y subunit gamma. 61
31762107 2020
13
Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis. 61
31869662 2020
14
Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method. 61
31343435 2020
15
Oncolytic Herpes Simplex Virus Prevents Premalignant Lesions from Progressing to Cancer. 61
31909180 2020
16
H19 lncRNA: Roles in tumorigenesis. 61
31855739 2020
17
RANKL triggers resistance to TRAIL-induced cell death in oral squamous cell carcinoma. 61
31309556 2020
18
Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection. 61
31706945 2020
19
Is toombak a risk factor for oral leukoplakia and oral squamous cell carcinoma ? A systematic review. 61
31436350 2020
20
Long noncoding RNA LINC00958 promotes the oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ. 61
31442551 2020
21
Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma. 61
32027770 2020
22
Expression and clinicopathologic significance of coxsackie-adenovirus receptor in oral squamous cell carcinoma. 61
31606425 2020
23
Value of SUVmax for the Prediction of Bone Invasion in Oral Squamous Cell Carcinoma. 61
32024247 2020
24
Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma. 61
31966079 2020
25
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. 61
31857698 2020
26
[Construction of an oral squamous cell carcinoma cell line for stable PA28γ overexpression]. 61
32037759 2020
27
Log Odds of Positive Lymph Nodes is Not Superior to the Number of Positive Lymph Nodes in Predicting Overall Survival in Patients With Oral Squamous Cell Carcinomas. 61
31705864 2020
28
Perinerural, lymphovascular and depths of invasion in extrapolating nodal metastasis in oral cancer. 61
31139977 2020
29
Association of MAPK and its regulatory miRNAs (603, 4301, 8485, and 4731) with the malignant transformation of oral lichen planus. 61
31828562 2020
30
Aberrant Kank1 expression regulates YAP to promote apoptosis and inhibit proliferation in OSCC. 61
31338836 2020
31
MiR-155-5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2. 61
31918270 2020
32
Development and validation of a seven-immune-feature-based prognostic score for oral squamous cell carcinoma after curative resection. 61
31304591 2020
33
MIR4435-2HG regulates cancer cell behaviors in oral squamous cell carcinoma cell growth by upregulating TGF-β1. 61
32016787 2020
34
Cisplatin-induced programed cell death ligand-2 expression associates with metastasis ability in oral squamous cell carcinoma. 61
32012401 2020
35
Tumor-infiltrating lymphocyte-derived MLL2 independently predicts disease-free survival for patients with early-stage oral squamous cell carcinoma. 61
31660637 2020
36
Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma. 61
31877368 2020
37
Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma. 61
32037955 2020
38
Diminished CD68+ cancer-associated fibroblasts subset induces Tregs infiltration and predicts poor prognosis of oral squamous cell carcinoma patients. 61
32035062 2020
39
Study on the targeted therapy of oral squamous cell carcinoma with a plasmid expressing PE38KDEL toxin under control of the SERPINB3 promoter. 61
32017381 2020
40
[Effect of the focal adhesion kinase inhibitor TAE226 on the epithelial-mesenchymal transition in human oral squamous cell carcinoma cell line]. 61
32037761 2020
41
MicroRNA-504 functions as a tumor suppressor in oral squamous cell carcinoma through inhibiting cell proliferation, migration and invasion by targeting CDK6. 61
31812760 2020
42
'Search less, verify more' - Reviewing salivary biomarkers in oral cancer detection. 61
32027406 2020
43
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway. 61
32017846 2020
44
Point-of-care oral cytology tool for the screening and assessment of potentially malignant oral lesions. 61
32032477 2020
45
Loss of heterozygosity and immunoexpression of PTEN in oral epithelial dysplasia and squamous cell carcinoma. 61
31730755 2020
46
MicroRNA-96-5p promotes proliferation, invasion and EMT of oral carcinoma cells by directly targeting FOXF2. 61
32014885 2020
47
A 4-gene signature from histologically normal surgical margins predicts local recurrence in patients with oral carcinoma: clinical validation. 61
32015424 2020
48
CYFRA 21-1 and MMP-9 as salivary biomarkers for the detection of oral squamous cell carcinoma: a systematic review of diagnostic test accuracy. 61
32035907 2020
49
Diagnostic utility of touch imprint cytology for intraoperative assessment of surgical margins and sentinel lymph nodes in oral squamous cell carcinoma patients using four different cytological stains. 61
31675175 2020
50
Knockdown of Long Non-Coding RNA (lncRNA) Colon Cancer-Associated Transcript-1 (CCAT1) Suppresses Oral Squamous Cell Carcinoma Proliferation, Invasion, and Migration by Inhibiting the Discoidin Domain Receptor 2 (DDR2)/ERK/AKT Axis. 61
32009633 2020

Variations for Oral Squamous Cell Carcinoma

Cosmic variations for Oral Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification EMS1 Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification TAOS1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification ORAOV1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 UCA1 MEG3 HOTAIR

GO Terms for Oral Squamous Cell Carcinoma

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.16 MIR21 MIR137
2 negative regulation of angiogenesis GO:0016525 9.13 MIR21 MIR193A MIR137
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.8 MIR21 MIR193A MIR137

Molecular functions related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.92 MIR21 MIR193A MIR137 MIR100

Sources for Oral Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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