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OSMF
MCID: ORL004
MIFTS: 59

Oral Submucous Fibrosis (OSMF)

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Oral Submucous Fibrosis

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MalaCards integrated aliases for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 12 77 54 60 56 45 15 17 74
Oral Submucosal Fibrosis, Including of Tongue 12 74
Osmf 54 60
Oral Cavity Submucous Fibrosis 12
Oral Submucosal Fibrosis 12

Characteristics:

Orphanet epidemiological data:

60
oral submucous fibrosis
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 34 35


External Ids:

Disease Ontology 12 DOID:5773
ICD9CM 36 528.8
MeSH 45 D009914
NCIt 51 C34866
SNOMED-CT 69 32883009
ICD10 34 K13.5
ICD10 via Orphanet 35 K13.5
UMLS via Orphanet 75 C0029172
Orphanet 60 ORPHA357154
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Summaries for Oral Submucous Fibrosis

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NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 357154Disease definitionOral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cellcancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.Visit the Orphanet disease page for more resources.

MalaCards based summary : Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral leukoplakia and squamous cell carcinoma, and has symptoms including oral manifestations An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways/superpathways are GPCR Pathway and Cytokine Signaling in Immune system. The drugs Hydrocortisone acetate and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and liver, and related phenotypes are narrow mouth and abnormality of the pharynx

Wikipedia : 77 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, premalignant (1% transformation risk)... more...

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Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 oral leukoplakia 30.7 GSTM1 TP53
2 squamous cell carcinoma 30.1 CDH1 CYP1A1 MMP2 PTGS2 TP53
3 oral cancer 28.9 CDH1 CYP1A1 GSTM1 MMP2 MMP9 PTGS2
4 oral squamous cell carcinoma 10.7
5 leukoplakia 10.7
6 leukoregulin 10.4 PTGS2 TGFB1
7 heritable pulmonary arterial hypertension 10.3 ENG TGFB1
8 diabetic foot ulcers 10.2 MMP9 TGFB1
9 autosomal recessive cutis laxa type i 10.2 LOX TGFB1
10 rheumatoid nodulosis 10.2 MMP3 MMP9
11 fibromatosis, gingival, 1 10.2 MMP2 TGFB1
12 verrucous carcinoma 10.2
13 pemphigus 10.2
14 spondylolisthesis 10.2 MMP3 PTGS2
15 autoimmune inner ear disease 10.2 MMP9 TIMP1
16 blepharochalasis 10.2 MMP3 MMP9
17 gingival hypertrophy 10.2 MMP3 MMP9
18 norwegian scabies 10.1 GSTM1 TGFB1
19 pemphigus vulgaris, familial 10.1
20 deficiency anemia 10.1
21 pemphigus vulgaris 10.1
22 iron metabolism disease 10.1
23 papilloma 10.1
24 burning mouth syndrome 10.1
25 lichen planus 10.1
26 oral lichen planus 10.1
27 extracranial arteriovenous malformation 10.1 MMP2 MMP9
28 focal myositis 10.1 MMP2 MMP9
29 microcystic meningioma 10.1 MMP2 TIMP1
30 fungal keratitis 10.1 MMP9 TIMP1
31 intracranial aneurysm 10.1 ENG LOX MMP2
32 villous adenocarcinoma 10.1 MMP2 MMP9
33 bone inflammation disease 10.1 MMP3 PTGS2 TIMP1
34 lentigo maligna melanoma 10.1 MMP2 MMP9
35 psammomatous meningioma 10.1 MMP2 MMP9
36 cryptogenic organizing pneumonia 10.1 MMP9 TIMP1
37 acute transverse myelitis 10.1 MMP2 MMP9
38 senile ectropion 10.1 MMP2 MMP9
39 hypertrophic scars 10.1 MMP2 TGFB1 TIMP1
40 urinary tract obstruction 10.1 CDH1 PTGS2 TGFB1
41 internal hemorrhoid 10.1 MMP2 MMP9
42 protoplasmic astrocytoma 10.1 PTGS2 TP53
43 adult astrocytic tumour 10.0 MMP3 MMP9
44 pulmonary fibrosis 10.0 MMP9 TGFB1 TIMP1
45 arteriovenous malformation 10.0 ENG MMP3 MMP9
46 recurrent respiratory papillomatosis 10.0 PTGS2 TP53
47 ischemic colitis 10.0 MMP2 MMP9
48 light chain deposition disease 10.0 MMP2 MMP9
49 non-proliferative fibrocystic change of the breast 10.0 ENG TP53
50 interstitial lung disease 10.0 MMP9 TGFB1 TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to Oral Submucous Fibrosis
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Symptoms & Phenotypes for Oral Submucous Fibrosis

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Human phenotypes related to Oral Submucous Fibrosis:

60 33 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 narrow mouth 60 33 hallmark (90%) Very frequent (99-80%) HP:0000160
2 abnormality of the pharynx 60 33 hallmark (90%) Very frequent (99-80%) HP:0000600
3 cheilitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100825
4 flexion contracture 60 33 frequent (33%) Frequent (79-30%) HP:0001371
5 trismus 60 33 frequent (33%) Frequent (79-30%) HP:0000211
6 oropharyngeal squamous cell carcinoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0012182
7 abnormality of the oral cavity 60 Very frequent (99-80%)

UMLS symptoms related to Oral Submucous Fibrosis:


oral manifestations

GenomeRNAi Phenotypes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CDH1 GSTM1 MMP2 PTGS2 TGFB1 TIMP1

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 CDH1 CYP1A1 ENG LOX MMP2 MMP9
2 homeostasis/metabolism MP:0005376 10.17 CDH1 CYP1A1 ENG LOX MMP2 MMP3
3 growth/size/body region MP:0005378 10.13 CDH1 CYP1A1 ENG MMP2 MMP9 PTGS2
4 hematopoietic system MP:0005397 10.11 CYP1A1 ENG MMP2 MMP3 MMP9 PTGS2
5 immune system MP:0005387 10.06 CDH1 CYP1A1 MMP2 MMP3 MMP9 PTGS2
6 mortality/aging MP:0010768 10.02 CDH1 CYP1A1 ENG LOX MMP2 MMP9
7 digestive/alimentary MP:0005381 9.97 CDH1 ENG MMP9 PTGS2 TGFB1 TP53
8 integument MP:0010771 9.91 CDH1 ENG LOX MMP9 PTGS2 TGFB1
9 muscle MP:0005369 9.8 ENG LOX MMP2 MMP9 PTGS2 TGFB1
10 neoplasm MP:0002006 9.7 CDH1 MMP2 MMP9 PTGS2 TGFB1 TIMP1
11 respiratory system MP:0005388 9.56 ENG LOX MMP2 MMP9 PTGS2 TGFB1
12 skeleton MP:0005390 9.17 MMP2 MMP3 MMP9 PTGS2 TGFB1 TIMP1
Sources

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
2
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
3
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
4 Anti-Inflammatory Agents Phase 3,Phase 2
5 Antioxidants Phase 3
6 Hydrocortisone 17-butyrate 21-propionate Phase 3
7 Viscosupplements Phase 3
8 Hydrocortisone-17-butyrate Phase 3
9 Adjuvants, Immunologic Phase 3
10 Immunologic Factors Phase 3
11 Hydrocortisone hemisuccinate Phase 3
12 Protective Agents Phase 3
13
tannic acid Approved Phase 2 1401-55-4
14
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
15
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
16
leucovorin Approved Phase 2 58-05-9 6006 143
17
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
18
Tegafur Approved, Investigational Phase 2 17902-23-7 5386
19 Analgesics, Non-Narcotic Phase 2
20 Antirheumatic Agents Phase 2
21 Analgesics Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Astragalus Phase 2
26 Antimetabolites Phase 2
27 Immunoglobulins
28 Antibodies
29 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study Completed NCT02714543 Phase 3 aloevera juice;Hydrocortisone;Hyaluronic Acid;antioxidant;aloevera gel
2 Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF) Unknown status NCT02645656 Phase 2 Curcumin Arm
3 Efficacy of Curcumin in Oral Submucous Fibrosis Recruiting NCT03511261 Phase 2 10% Curcumin mucoadhesive gel;Curcumin capsules 500mg;5% curcumin mucoadhesive gel + Curcumin capsules 250 mg;Placebo capsule
4 A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy Terminated NCT01720563 Phase 2 Astragalus polysaccharides 500 mg;Placebo
5 Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis Completed NCT03011086
6 Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis Completed NCT02711046 Not Applicable
7 Epithelial Mesenchymal Transition Markers in OSMF Completed NCT03732872

Search NIH Clinical Center for Oral Submucous Fibrosis

Cochrane evidence based reviews: oral submucous fibrosis

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Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

42
Tongue, Skin, Liver, Testes, Endothelial, T Cells, Salivary Gland
Sources

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50) (show all 716)
# Title Authors Year
1
"Introducing Modified Dakkak and Bennett Grading System for Indian Food in Oral Submucous Fibrosis": A Dharwad Study. ( 29624459 )
2019
2
Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using 1H nuclear magnetic resonance spectroscopy. ( 30384150 )
2019
3
A potential new oral mapping (OM) method in the clinical evaluation and documentation of oral submucous fibrosis-A prospective clinical crossover study. ( 30604897 )
2019
4
Impact of socioeconomic inequalities on quality of life in oral submucous fibrosis patients. ( 30669879 )
2019
5
Differential expression of salivary S100A7 in oral submucous fibrosis. ( 30705567 )
2019
6
Oral submucous fibrosis: a clinicopathological study of 674 cases in China. ( 30715767 )
2019
7
Efficacy of curcumin for management of oral submucous fibrosis: a systematic review of randomized clinical trials. ( 30745280 )
2019
8
Habit History in Oral Submucous Fibrosis: Have We Over Emphasized? ( 30803207 )
2019
9
Evaluation of Gustatory Function in Oral Submucous Fibrosis Patients and Gutka Chewers ( 30803222 )
2019
10
Revisiting and revising the definition of oral submucous fibrosis. ( 30853277 )
2019
11
Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition. ( 30884781 )
2019
12
Endorsing cellular competitiveness in aberrant epithelium of oral submucous fibrosis progression: neighbourhood analysis of immunohistochemical attributes. ( 29687243 )
2018
13
Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint. ( 29422478 )
2018
14
Bibliometric analysis of 100 most cited articles on oral submucous fibrosis. ( 29905986 )
2018
15
Conservative management of Oral Submucous Fibrosis in early and intermediate stage. ( 29892527 )
2018
16
Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis. ( 29665273 )
2018
17
miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2. ( 29893466 )
2018
18
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail. ( 29328529 )
2018
19
"A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients": A Commentary. ( 29859162 )
2018
20
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry ( 29699065 )
2018
21
Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal". ( 29682779 )
2018
22
Data regarding clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia. ( 29900214 )
2018
23
New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment. ( 29428570 )
2018
24
Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis. ( 29652009 )
2018
25
Reply to: Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal". ( 29719926 )
2018
26
A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial. ( 29900913 )
2018
27
Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry. ( 28826108 )
2018
28
Oral submucous fibrosis: A clinico-histopathological correlational study. ( 29893325 )
2018
29
Validity of Chronic Oral Mucosal Diseases Questionnaire in oral submucous fibrosis. ( 29948274 )
2018
30
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
31
Impact of oral submucous fibrosis on oral health-related quality of life: A condition-specific OHRQoL-OSF instrument analysis. ( 29928774 )
2018
32
Significance of Serum Nitric Oxide and Superoxide Dismutase in Oral Submucous Fibrosis and Squamous Cell Carcinoma: A Comparative Study. ( 29875574 )
2018
33
Assessment of the quality of life and performance status in patients with oral submucous fibrosis in central India. ( 29785159 )
2018
34
TFM classification and Staging of oral submucous fibrosis: A new proposal. ( 29405430 )
2018
35
Fibrotomy with diode laser (980A nm) and habit correlation in oral submucous fibrosis: a report of 30 cases. ( 29948450 )
2018
36
Mouth-opening device as a treatment modality in trismus patients with head and neck cancer and oral submucous fibrosis: a prospective study. ( 29696422 )
2018
37
Is matrix stiffness a cause for malignant transformation of oral submucous fibrosis? ( 29656454 )
2018
38
An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma. ( 30402477 )
2018
39
Immunolocalization of c-Jun in normal mucosa, oral submucous fibrosis, epithelial dysplasia, and oral squamous cell carcinoma: A comparative study. ( 30488826 )
2018
40
Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: A preliminary study. ( 29478271 )
2018
41
Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation. ( 29485009 )
2018
42
Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis. ( 29516926 )
2018
43
Differential expression of organic cation transporter 3 in oral submucous fibrosis-associated buccal squamous cell carcinoma. ( 29523428 )
2018
44
Development and validation of oral health-related quality of life measure in oral submucous fibrosis. ( 29570905 )
2018
45
Quality of Life-related "Patient-reported Outcome Measures" in Oral Submucous Fibrosis Patients. ( 29603708 )
2018
46
Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis. ( 30001387 )
2018
47
Growth-regulated oncogene-α from oral submucous fibrosis fibroblasts promotes malignant transformation of oral precancerous cells. ( 30035347 )
2018
48
Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis. ( 30046309 )
2018
49
Temporomandibular joint changes in oral submucous fibrosis- A magnetic resonance imaging study. ( 30057710 )
2018
50
Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial. ( 30059188 )
2018
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Variations for Oral Submucous Fibrosis

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Expression for Oral Submucous Fibrosis

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Search GEO for disease gene expression data for Oral Submucous Fibrosis.
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Pathways for Oral Submucous Fibrosis

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Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
GPCR Pathway 65
Show member pathways
 13.54 MMP2 MMP3 MMP9 PTGS2 TGFB1 TIMP1
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.2 MMP2 MMP3 MMP9 PTGS2 TGFB1 TIMP1
3
Endometrial cancer 38
Show member pathways
 12.72 CDH1 MMP3 MMP9 TGFB1 TP53
4
Gastric cancer 38
Show member pathways
 12.6 CDH1 GSTM1 TGFB1 TP53
5
Pathways in cancer 38
12.59 CDH1 GSTM1 MMP2 MMP9 PTGS2 TGFB1
6
Glioma 38
Show member pathways
 12.54 CDH1 MMP2 MMP9 TP53
7
Degradation of the extracellular matrix 67
Show member pathways
 12.45 CDH1 LOX MMP2 MMP3 MMP9 TGFB1
8
Proteoglycans in cancer 38
12.17 MMP2 MMP9 TGFB1 TP53
9
Fluid shear stress and atherosclerosis 38
11.98 GSTM1 MMP2 MMP9 TP53
10
SMAD Signaling Network 65
11.91 MMP2 TGFB1 TP53
11
Adhesion 4
11.91 CDH1 MMP2 MMP3 MMP9
12
Spinal Cord Injury 1
11.89 MMP9 PTGS2 TGFB1 TP53
13
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.88 MMP2 MMP3 MMP9
14
Colorectal Cancer Metastasis 65
11.85 CDH1 MMP2 MMP9 PTGS2 TGFB1 TP53
15
TNF signaling pathway 38
11.81 MMP3 MMP9 PTGS2
16
Matrix Metalloproteinases 1
Show member pathways
 11.79 MMP2 MMP3 MMP9 TIMP1
17
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.66 CDH1 MMP2 MMP9
18
Bladder cancer 38 1
11.64 CDH1 MMP2 MMP9 TP53
19
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.61 MMP3 MMP9 PTGS2 TGFB1
20
Transcription_P53 signaling pathway 23
11.56 MMP2 TGFB1 TP53
21
Interleukin-4 and 13 signaling 67
11.56 MMP2 MMP3 MMP9 PTGS2 TGFB1 TIMP1
22
Lung fibrosis 1
11.53 MMP2 MMP9 TGFB1 TIMP1
23
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 MMP2 MMP3 MMP9 PTGS2
24
IL-2 Gene Expression in Activated and Quiescent T-Cells 65
Show member pathways
 11.46 MMP2 MMP9 TGFB1
25
Cell adhesion_ECM remodeling 23
11.45 MMP2 MMP3 MMP9 TIMP1
26
Hepatitis C and Hepatocellular Carcinoma 1
11.44 PTGS2 TGFB1 TP53
27
Angiogenesis (CST) 4
11.12 ENG MMP2 MMP3 MMP9 PTGS2 TGFB1
28
Plasma membrane estrogen receptor signaling 1
11.07 MMP2 MMP9
29
IL1 and megakaryocytes in obesity 1
11.04 MMP9 TIMP1
30
Naphthalene metabolism 23
11.02 CYP1A1 GSTM1
31
A-beta Pathways: Plaque Formation and APP Metabolism 66
10.99 MMP2 MMP9
32
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 1
10.87 CDH1 TGFB1
33
Syndecan-1-mediated signaling events 1
10.84 MMP9 TGFB1
Sources

GO Terms for Oral Submucous Fibrosis

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Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CDH1 LOX MMP2 MMP3 MMP9 TGFB1
2 extracellular space GO:0005615 9.5 ENG LOX MMP2 MMP3 MMP9 TGFB1
3 extracellular matrix GO:0031012 9.1 LOX MMP2 MMP3 MMP9 TGFB1 TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.86 MMP9 PTGS2 TGFB1 TP53
2 response to organic cyclic compound GO:0014070 9.76 CYP1A1 PTGS2 TGFB1
3 aging GO:0007568 9.76 CYP1A1 PTGS2 TGFB1 TIMP1
4 wound healing GO:0042060 9.71 LOX TGFB1 TIMP1
5 cellular response to mechanical stimulus GO:0071260 9.69 ENG PTGS2 TGFB1
6 response to drug GO:0042493 9.63 CDH1 CYP1A1 ENG LOX PTGS2 TGFB1
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.62 PTGS2 TGFB1
8 positive regulation of collagen biosynthetic process GO:0032967 9.62 ENG TGFB1
9 response to immobilization stress GO:0035902 9.61 CYP1A1 TGFB1
10 long-chain fatty acid biosynthetic process GO:0042759 9.61 CYP1A1 PTGS2
11 response to hypoxia GO:0001666 9.61 CYP1A1 MMP2 TGFB1
12 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.6 ENG TGFB1
13 response to vitamin D GO:0033280 9.59 PTGS2 TGFB1
14 positive regulation of protein oligomerization GO:0032461 9.58 MMP3 TP53
15 embryo implantation GO:0007566 9.58 MMP2 MMP9 PTGS2
16 negative regulation of cell-cell adhesion GO:0022408 9.57 CDH1 TGFB1
17 extracellular matrix disassembly GO:0022617 9.56 MMP2 MMP3 MMP9 TIMP1
18 cell activation GO:0001775 9.55 TGFB1 TIMP1
19 collagen catabolic process GO:0030574 9.54 MMP2 MMP3 MMP9
20 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.52 TGFB1 TP53
21 positive regulation of protein import into nucleus GO:0042307 9.5 CDH1 PTGS2 TGFB1
22 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.49 TGFB1 TIMP1
23 regulation of neuroinflammatory response GO:0150077 9.48 MMP3 MMP9
24 response to organic substance GO:0010033 9.35 CDH1 CYP1A1 PTGS2 TGFB1 TIMP1
25 cytokine-mediated signaling pathway GO:0019221 9.17 MMP2 MMP3 MMP9 PTGS2 TGFB1 TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.81 CDH1 CYP1A1 LOX MMP2 MMP3 MMP9
2 protein homodimerization activity GO:0042803 9.8 CDH1 ENG GSTM1 PTGS2 TGFB1
3 zinc ion binding GO:0008270 9.77 MMP2 MMP3 MMP9 TIMP1 TP53
4 metallopeptidase activity GO:0008237 9.63 MMP2 MMP3 MMP9
5 metalloendopeptidase activity GO:0004222 9.5 MMP2 MMP3 MMP9
6 type I transforming growth factor beta receptor binding GO:0034713 9.26 ENG TGFB1
7 enzyme binding GO:0019899 9.02 CYP1A1 GSTM1 PTGS2 TGFB1 TP53
8 type II transforming growth factor beta receptor binding GO:0005114 8.96 ENG TGFB1
9 protein binding GO:0005515 10.21 CDH1 CYP1A1 ENG LOR LOX MMP2
Sources

Sources for Oral Submucous Fibrosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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