OSMF
MCID: ORL004
MIFTS: 57

Oral Submucous Fibrosis (OSMF)

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Oral Submucous Fibrosis

MalaCards integrated aliases for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 12 76 53 59 55 44 15 73
Oral Submucosal Fibrosis, Including of Tongue 12 73
Osmf 53 59
Oral Cavity Submucous Fibrosis 12
Oral Submucosal Fibrosis 12

Characteristics:

Orphanet epidemiological data:

59
oral submucous fibrosis
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:5773
ICD10 33 K13.5
ICD9CM 35 528.8
MeSH 44 D009914
NCIt 50 C34866
SNOMED-CT 68 32883009
Orphanet 59 ORPHA357154
ICD10 via Orphanet 34 K13.5
UMLS via Orphanet 74 C0029172

Summaries for Oral Submucous Fibrosis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 357154Disease definitionOral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cellcancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.Visit the Orphanet disease page for more resources.

MalaCards based summary : Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to leukoplakia and oral leukoplakia, and has symptoms including oral manifestations An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Gastric cancer. The drugs Hyaluronic acid and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and liver, and related phenotypes are flexion contracture and narrow mouth

Wikipedia : 76 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, premalignant (1% transformation risk)... more...

Related Diseases for Oral Submucous Fibrosis

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 leukoplakia 31.1 CYP1A1 GSTM1 GSTT1
2 oral leukoplakia 31.1 GSTM1 GSTT1
3 squamous cell carcinoma 30.7 CDH1 CYP1A1 MMP2 PTGS2
4 oral cancer 29.9 CDH1 CYP1A1 GSTM1 GSTT1 MMP2 PTGS2
5 oral squamous cell carcinoma 10.7
6 leukoregulin 10.2 PTGS2 TGFB1
7 autosomal recessive cutis laxa type i 10.2 LOX TGFB1
8 hearing loss, noise-induced 10.2 GSTM1 GSTT1
9 colorectal cancer, childhood 10.2 CYP1A1 GSTM1
10 sister chromatid exchange, frequency of 10.2 GSTM1 GSTT1
11 isolated cleft lip 10.2 GSTM1 GSTT1
12 verrucous carcinoma 10.2
13 pemphigus 10.2
14 norwegian scabies 10.2 GSTM1 TGFB1
15 spondylolisthesis 10.2 MMP3 PTGS2
16 drug-induced hepatitis 10.2 GSTM1 GSTT1
17 toxic oil syndrome 10.1 CYP1A1 GSTM1
18 heritable pulmonary arterial hypertension 10.1 ENG TGFB1
19 pemphigus vulgaris, familial 10.1
20 pemphigus vulgaris 10.1
21 iron metabolism disease 10.1
22 papilloma 10.1
23 burning mouth syndrome 10.1
24 lichen planus 10.1
25 oral lichen planus 10.1
26 fibromatosis, gingival, 1 10.1 MMP2 TGFB1
27 cardia cancer 10.1 GSTM1 GSTT1
28 spastic entropion 10.1 MMP2 MMP3
29 bone inflammation disease 10.1 MMP3 PTGS2 TIMP1
30 pulmonary disease, chronic obstructive 10.0 GSTM1 TGFB1 TIMP1
31 microcystic meningioma 10.0 MMP2 TIMP1
32 corneal ulcer 10.0 MMP2 MMP3
33 conjunctival nevus 10.0 MMP2 TIMP1
34 breast disease 10.0 CYP1A1 ENG TGFB1
35 nasal cavity squamous cell carcinoma 10.0 MMP2 TIMP1
36 maxillary cancer 10.0 MMP2 TIMP1
37 hypertrophic scars 10.0 MMP2 TGFB1 TIMP1
38 osteoarthritis 10.0 MMP3 PTGS2 TGFB1 TIMP1
39 basal cell carcinoma 10.0 CYP1A1 GSTM1 GSTT1 MMP3
40 clopidogrel resistance 10.0 CYP1A1 PTGS2
41 masticatory muscles, hypertrophy of 10.0
42 myositis 10.0
43 body mass index quantitative trait locus 1 10.0
44 anxiety 10.0
45 muscle hypertrophy 10.0
46 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.0
47 deficiency anemia 10.0
48 diabetes mellitus 10.0
49 spinal muscular atrophy 10.0
50 mucositis 10.0

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to Oral Submucous Fibrosis

Symptoms & Phenotypes for Oral Submucous Fibrosis

Human phenotypes related to Oral Submucous Fibrosis:

59 32 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 flexion contracture 59 32 frequent (33%) Frequent (79-30%) HP:0001371
2 narrow mouth 59 32 hallmark (90%) Very frequent (99-80%) HP:0000160
3 abnormality of the pharynx 59 32 hallmark (90%) Very frequent (99-80%) HP:0000600
4 cheilitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100825
5 trismus 59 32 frequent (33%) Frequent (79-30%) HP:0000211
6 oropharyngeal squamous cell carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0012182
7 abnormality of the oral cavity 59 Very frequent (99-80%)

UMLS symptoms related to Oral Submucous Fibrosis:


oral manifestations

GenomeRNAi Phenotypes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CDH1 DKK3 GSTM1 MMP2 PTGS2 TGFB1

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CDH1 CYP1A1 ENG LOX MMP2 PTGS2
2 homeostasis/metabolism MP:0005376 9.96 CDH1 CYP1A1 DKK3 ENG LOX MMP2
3 hematopoietic system MP:0005397 9.92 CYP1A1 DKK3 ENG MMP2 MMP3 PTGS2
4 immune system MP:0005387 9.76 CDH1 CYP1A1 DKK3 MMP2 MMP3 PTGS2
5 neoplasm MP:0002006 9.35 CDH1 MMP2 PTGS2 TGFB1 TIMP1
6 respiratory system MP:0005388 9.1 ENG LOX MMP2 PTGS2 TGFB1 TIMP1

Drugs & Therapeutics for Oral Submucous Fibrosis

Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
2
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
4 Anti-Inflammatory Agents Phase 3,Phase 2
5 Cortisol succinate Phase 3
6 Viscosupplements Phase 3
7 Adjuvants, Immunologic Phase 3
8 Immunologic Factors Phase 3
9 Hydrocortisone 17-butyrate 21-propionate Phase 3
10 Hydrocortisone-17-butyrate Phase 3
11 Antioxidants Phase 3
12 Protective Agents Phase 3
13
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
14 tannic acid Approved Phase 2
15
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
16
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
17
Tegafur Approved, Investigational Phase 2 17902-23-7 5386
18
leucovorin Approved Phase 2 58-05-9 6006 143
19 Peripheral Nervous System Agents Phase 2
20 Analgesics Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 2
23 Antirheumatic Agents Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Antimetabolites Phase 2
26 Astragalus Phase 2
27 Autoantibodies
28 Immunoglobulins
29 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study Completed NCT02714543 Phase 3 aloevera juice;Hydrocortisone;Hyaluronic Acid;antioxidant;aloevera gel
2 Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF) Unknown status NCT02645656 Phase 2 Curcumin Arm
3 Efficacy of Curcumin in Oral Submucous Fibrosis Recruiting NCT03511261 Phase 2 10% Curcumin mucoadhesive gel;Curcumin capsules 500mg;5% curcumin mucoadhesive gel + Curcumin capsules 250 mg;Placebo capsule
4 A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy Terminated NCT01720563 Phase 2 Astragalus polysaccharides 500 mg;Placebo
5 Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis Completed NCT03011086
6 Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis Completed NCT02711046 Not Applicable
7 Epithelial Mesenchymal Transition Markers in OSMF Completed NCT03732872

Search NIH Clinical Center for Oral Submucous Fibrosis

Cochrane evidence based reviews: oral submucous fibrosis

Genetic Tests for Oral Submucous Fibrosis

Anatomical Context for Oral Submucous Fibrosis

MalaCards organs/tissues related to Oral Submucous Fibrosis:

41
Tongue, Skin, Liver, Lung, Bone, Colon, Ovary

Publications for Oral Submucous Fibrosis

Articles related to Oral Submucous Fibrosis:

(show top 50) (show all 700)
# Title Authors Year
1
Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using 1H nuclear magnetic resonance spectroscopy. ( 30384150 )
2019
2
Endorsing cellular competitiveness in aberrant epithelium of oral submucous fibrosis progression: neighbourhood analysis of immunohistochemical attributes. ( 29687243 )
2018
3
Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint. ( 29422478 )
2018
4
Bibliometric analysis of 100 most cited articles on oral submucous fibrosis. ( 29905986 )
2018
5
Conservative management of Oral Submucous Fibrosis in early and intermediate stage. ( 29892527 )
2018
6
Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis. ( 29665273 )
2018
7
miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2. ( 29893466 )
2018
8
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail. ( 29328529 )
2018
9
"A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients": A Commentary. ( 29859162 )
2018
10
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry ( 29699065 )
2018
11
Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal". ( 29682779 )
2018
12
Data regarding clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia. ( 29900214 )
2018
13
New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment. ( 29428570 )
2018
14
Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis. ( 29652009 )
2018
15
Reply to: Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal". ( 29719926 )
2018
16
A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial. ( 29900913 )
2018
17
Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry. ( 28826108 )
2018
18
Oral submucous fibrosis: A clinico-histopathological correlational study. ( 29893325 )
2018
19
Validity of Chronic Oral Mucosal Diseases Questionnaire in oral submucous fibrosis. ( 29948274 )
2018
20
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
21
Impact of oral submucous fibrosis on oral health-related quality of life: A condition-specific OHRQoL-OSF instrument analysis. ( 29928774 )
2018
22
Significance of Serum Nitric Oxide and Superoxide Dismutase in Oral Submucous Fibrosis and Squamous Cell Carcinoma: A Comparative Study. ( 29875574 )
2018
23
Assessment of the quality of life and performance status in patients with oral submucous fibrosis in central India. ( 29785159 )
2018
24
TFM classification and Staging of oral submucous fibrosis: A new proposal. ( 29405430 )
2018
25
Fibrotomy with diode laser (980A nm) and habit correlation in oral submucous fibrosis: a report of 30 cases. ( 29948450 )
2018
26
Mouth-opening device as a treatment modality in trismus patients with head and neck cancer and oral submucous fibrosis: a prospective study. ( 29696422 )
2018
27
Immunolocalization of c-Jun in normal mucosa, oral submucous fibrosis, epithelial dysplasia, and oral squamous cell carcinoma: A comparative study. ( 30488826 )
2018
28
An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma. ( 30402477 )
2018
29
Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis. ( 29516926 )
2018
30
Differential expression of organic cation transporter 3 in oral submucous fibrosis-associated buccal squamous cell carcinoma. ( 29523428 )
2018
31
Development and validation of oral health-related quality of life measure in oral submucous fibrosis. ( 29570905 )
2018
32
Quality of Life-related "Patient-reported Outcome Measures" in Oral Submucous Fibrosis Patients. ( 29603708 )
2018
33
"Introducing Modified Dakkak and Bennett Grading System for Indian Food in Oral Submucous Fibrosis": A Dharwad Study. ( 29624459 )
2018
34
Is matrix stiffness a cause for malignant transformation of oral submucous fibrosis? ( 29656454 )
2018
35
Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis. ( 30001387 )
2018
36
Growth-regulated oncogene-α from oral submucous fibrosis fibroblasts promotes malignant transformation of oral precancerous cells. ( 30035347 )
2018
37
Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis. ( 30046309 )
2018
38
Temporomandibular joint changes in oral submucous fibrosis- A magnetic resonance imaging study. ( 30057710 )
2018
39
Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial. ( 30059188 )
2018
40
Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva. ( 30072836 )
2018
41
Estimation of Salivary and Serum Lactate Dehydrogenase in Oral Submucous Fibrosis. ( 30123759 )
2018
42
Association between kharra chewing and periodontal health status in oral submucous fibrosis patients of Central India, Nagpur. ( 30131628 )
2018
43
New Directions for Oral Submucous Fibrosis Research: Whole Evaluation for Holistic Rehabilitation! ( 30150486 )
2018
44
Nasolabial and extended nasolabial flaps for reconstruction in oral submucous fibrosis. ( 30181986 )
2018
45
Polarized microscope assisted study of collagen fibres in Oral Submucous Fibrosis and their clinicopathologic correlation: An in-vitro study. ( 30191110 )
2018
46
Comparison of microvessel density using CD34 and CD105 in oral submucous fibrosis and its correlation with clinicopathological features: An immunohistochemical study. ( 30197335 )
2018
47
Surgical management of oral submucous fibrosis using buccal fat pad: a retrospective study of 30 cases. ( 30238329 )
2018
48
A New Intraoral Appliance for Trismus in Oral Submucous Fibrosis. ( 30271636 )
2018
49
Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis. ( 30329174 )
2018
50
Collagen Membrane Over Buccal Fat Pad Versus Buccal Fat Pad in Management of Oral Submucous Fibrosis: A Comparative Prospective Study. ( 30344390 )
2018

Variations for Oral Submucous Fibrosis

Expression for Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for Oral Submucous Fibrosis

Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 CYP1A1 GSTM1 GSTT1 PTGS2
2
Show member pathways
12.53 CDH1 GSTM1 GSTT1 TGFB1
3 12.45 CDH1 GSTM1 GSTT1 MMP2 PTGS2 TGFB1
4
Show member pathways
12.29 CDH1 LOX MMP2 MMP3 TGFB1 TIMP1
5 11.89 CDH1 MMP2 PTGS2 TGFB1
6 11.88 GSTM1 GSTT1 MMP2
7 11.8 CDH1 MMP2 MMP3
8
Show member pathways
11.68 MMP2 MMP3 TIMP1
9
Show member pathways
11.57 CYP1A1 GSTM1 GSTT1
10 11.5 MMP3 PTGS2 TGFB1
11 11.43 MMP2 TGFB1 TIMP1
12
Show member pathways
11.41 MMP2 MMP3 PTGS2
13 11.41 MMP2 MMP3 PTGS2 TGFB1 TIMP1
14 11.37 MMP2 MMP3 TIMP1
15 11.05 GSTM1 GSTT1
16 11.05 ENG MMP2 MMP3 PTGS2 TGFB1 TIMP1
17 10.88 CYP1A1 GSTM1 GSTT1
18 10.8 CDH1 TGFB1
19 10.7 GSTT1 PTGS2

GO Terms for Oral Submucous Fibrosis

Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 DKK3 ENG LOX MMP2 MMP3 TGFB1
2 extracellular matrix GO:0031012 9.02 LOX MMP2 MMP3 TGFB1 TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.71 CYP1A1 PTGS2 TGFB1
2 aging GO:0007568 9.71 CYP1A1 PTGS2 TGFB1 TIMP1
3 wound healing GO:0042060 9.67 LOX TGFB1 TIMP1
4 response to hypoxia GO:0001666 9.67 CYP1A1 MMP2 MMP3 TGFB1
5 cellular response to mechanical stimulus GO:0071260 9.65 ENG PTGS2 TGFB1
6 cytokine-mediated signaling pathway GO:0019221 9.65 MMP2 MMP3 PTGS2 TGFB1 TIMP1
7 extracellular matrix disassembly GO:0022617 9.63 MMP2 MMP3 TIMP1
8 face morphogenesis GO:0060325 9.6 MMP2 TGFB1
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.59 PTGS2 TGFB1
10 positive regulation of collagen biosynthetic process GO:0032967 9.58 ENG TGFB1
11 response to immobilization stress GO:0035902 9.58 CYP1A1 TGFB1
12 glutathione derivative biosynthetic process GO:1901687 9.57 GSTM1 GSTT1
13 long-chain fatty acid biosynthetic process GO:0042759 9.56 CYP1A1 PTGS2
14 response to vitamin D GO:0033280 9.55 PTGS2 TGFB1
15 negative regulation of cell-cell adhesion GO:0022408 9.52 CDH1 TGFB1
16 cell activation GO:0001775 9.51 TGFB1 TIMP1
17 positive regulation of protein import into nucleus GO:0042307 9.5 CDH1 PTGS2 TGFB1
18 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.43 TGFB1 TIMP1
19 response to drug GO:0042493 9.43 CDH1 CYP1A1 ENG LOX PTGS2 TGFB1
20 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.33 DKK3 ENG TGFB1
21 response to organic substance GO:0010033 9.02 CDH1 CYP1A1 PTGS2 TGFB1 TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.65 CDH1 ENG GSTM1 PTGS2 TGFB1
2 enzyme binding GO:0019899 9.46 CYP1A1 GSTM1 PTGS2 TGFB1
3 glutathione transferase activity GO:0004364 9.32 GSTM1 GSTT1
4 type I transforming growth factor beta receptor binding GO:0034713 8.96 ENG TGFB1
5 type II transforming growth factor beta receptor binding GO:0005114 8.62 ENG TGFB1

Sources for Oral Submucous Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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