MCID: ORL003
MIFTS: 36

Oral Tuberculosis

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Oral Tuberculosis

MalaCards integrated aliases for Oral Tuberculosis:

Name: Oral Tuberculosis 12 15 17
Tuberculosis, Oral 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:402
MeSH 44 D014393
SNOMED-CT 67 235067001
UMLS 70 C0041323

Summaries for Oral Tuberculosis

Disease Ontology : 12 A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located in tongue, located in palate, located in maxilla or located in mandible.

MalaCards based summary : Oral Tuberculosis, also known as tuberculosis, oral, is related to mycobacterium tuberculosis 1 and lepromatous leprosy, and has symptoms including oral manifestations An important gene associated with Oral Tuberculosis is NDUFA5 (NADH:Ubiquinone Oxidoreductase Subunit A5), and among its related pathways/superpathways are Immune response NFAT in immune response and Th17 cell differentiation. Affiliated tissues include tongue, lung and skin, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Oral Tuberculosis

Diseases related to Oral Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 529)
# Related Disease Score Top Affiliating Genes
1 mycobacterium tuberculosis 1 29.9 TNF PRF1 IFNG GNLY CD8A CD4
2 lepromatous leprosy 29.7 TNF IL2 IFNG
3 gingivitis 29.7 TNF IL2 IFNG
4 pulmonary tuberculosis 29.4 TNF IL2 IFNG C3
5 crohn's disease 29.0 TNF IL2 IFNG CRP CD4
6 disease by infectious agent 28.9 TNF IL2 IFNG GNLY CRP CD8A
7 leprosy 3 28.7 TNF NELFCD IL2 IFNG GNLY CD8A
8 cork-handlers' disease 10.4 CD8A CD4
9 early yaws 10.4 CD8A CD4
10 ventilation pneumonitis 10.3 CD8A CD4
11 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
12 ceftazidime allergy 10.3 GNLY CD4
13 latent syphilis 10.3 CD8A CD4
14 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
15 parapsoriasis 10.3 CD8A CD4
16 gastroduodenitis 10.3 CD8A CD4
17 norwegian scabies 10.3 CD8A CD4
18 granuloma annulare 10.3 TNF CD4
19 bird fancier's lung 10.3 CD8A CD4
20 variola major 10.3 CD8A CD4
21 listeria meningitis 10.3 TNF CD8A
22 central nervous system tuberculosis 10.3 TNF CD4
23 follicular mucinosis 10.3 CD8A CD4
24 spongiotic dermatitis 10.3 CD8A CD4
25 acute retinal necrosis syndrome 10.3 CD8A CD4
26 cerebral lymphoma 10.3 CD8A CD4
27 invasive malignant thymoma 10.3 CD8A CD4
28 west nile encephalitis 10.3 CD8A CD4
29 exanthema subitum 10.3 CD8A CD4
30 oral hairy leukoplakia 10.3 CD8A CD4
31 streptococcal toxic-shock syndrome 10.3 TNF IL2
32 esophageal candidiasis 10.3 CD8A CD4
33 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.3 CD8A CD4
34 ulcerative stomatitis 10.3 CD8A CD4
35 west nile fever 10.3 CD8A CD4
36 staphylococcal toxic shock syndrome 10.3 TNF IFNG
37 autoimmune myocarditis 10.3 TNF IFNG
38 subacute lymphocytic thyroiditis 10.3 IL2 CD4
39 ocular tuberculosis 10.3 IFNG CD4
40 spotted fever rickettsiosis 10.3 TNF IFNG
41 polyarticular juvenile idiopathic arthritis 10.3 TNF IFNG
42 bell's palsy 10.3 CD8A CD4
43 adenoid hypertrophy 10.3 CD8A CD4
44 anal margin carcinoma 10.3 PRF1 CD4
45 penicilliosis 10.2 IFNG CD4
46 chronic beryllium disease 10.2 TNF IFNG
47 type 1 diabetes mellitus 23 10.2 TNF CD8A CD4
48 purulent endophthalmitis 10.2 PRF1 CD4
49 granulomatous dermatitis 10.2 TNF CD8A CD4
50 pneumonic tularemia 10.2 TNF CD8A CD4

Graphical network of the top 20 diseases related to Oral Tuberculosis:



Diseases related to Oral Tuberculosis

Symptoms & Phenotypes for Oral Tuberculosis

UMLS symptoms related to Oral Tuberculosis:


oral manifestations

MGI Mouse Phenotypes related to Oral Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 C3 CD4 CD8A DGCR8 IFNG IL2
2 endocrine/exocrine gland MP:0005379 9.76 C3 CD4 CD8A IFNG IL2 MMUT
3 immune system MP:0005387 9.61 C3 CD4 CD8A CRP IFNG IL2
4 nervous system MP:0003631 9.28 C3 CD4 CD8A DGCR8 IFNG MMUT

Drugs & Therapeutics for Oral Tuberculosis

Search Clinical Trials , NIH Clinical Center for Oral Tuberculosis

Cochrane evidence based reviews: tuberculosis, oral

Genetic Tests for Oral Tuberculosis

Anatomical Context for Oral Tuberculosis

MalaCards organs/tissues related to Oral Tuberculosis:

40
Tongue, Lung, Skin, Bone Marrow, Bone, Lymph Node, Thymus

Publications for Oral Tuberculosis

Articles related to Oral Tuberculosis:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Oral tuberculosis in a patient with Crohn's disease on TNF-α blockers. 61
32977350 2021
2
Oral tuberculosis. 61
33188319 2020
3
Periodontitis and Cytomegalovirus Associate With Atherosclerosis Among HIV Patients After 5 Years on ART. 61
32541382 2020
4
Primary oral tuberculosis: A case series of a rare disease. 61
33456244 2020
5
Literature review of oral tuberculosis and report of a case with unique histological presentation. 61
32553318 2020
6
An Unusual Granular Ulcer Secondary Oral Tuberculosis of Vestibule Mandibular Mucosa. 61
32396968 2020
7
Primary oral tuberculosis - A case report. 61
33110314 2020
8
Oral ulcer as presentation of cavitating pulmonary tuberculosis. 61
33083228 2020
9
ENT manifestations of tuberculosis: an important aspect of ENT practice. 61
33117489 2020
10
Incidence and predictors of HIV related opportunistic infections after initiation of highly active antiretroviral therapy at Ayder Referral Hospital, Mekelle, Ethiopia: A retrospective single centered cohort study. 61
32310961 2020
11
Prevalence of oral lesions in tuberculosis: A cross sectional study. 61
31879619 2019
12
A case report of a tongue ulcer presented as the first sign of occult tuberculosis. 61
31036007 2019
13
Oral tuberculosis - Current concepts. 61
31143712 2019
14
Utility of fine needle aspiration cytology to diagnose intraoral tuberculosis and other oral granulomatous lesions. 61
30548220 2019
15
Oral tuberculosis mimicking a traumatic denture ulcer. 61
30722984 2019
16
Submuscular gluteal abcess: An unusual presentation of rare sacral tuberculosis. 61
30522080 2019
17
Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration. 61
30453628 2018
18
Chronic non-healing ulcer of the oral cavity: tuberculosis or carcinoma? 61
29790316 2018
19
Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico-in-vitro-in-vivo approach. 61
29174840 2018
20
Primary oral tuberculosis on the tongue mimicking squamous cell carcinoma. 61
29332657 2018
21
Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion. 61
29872238 2017
22
Usage of Molecular Pathology in a Rare Oral Tuberculosis Diagnosis. 61
28230001 2017
23
Oral tuberculosis. 61
27889200 2017
24
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma. 61
26927999 2016
25
Oral Tuberculosis: A Rare Manifestation of Disseminated Disease in a Patient with Dermatomyositis on Chronic Corticosteroids. 61
27895668 2016
26
Tuberculosis of the oral cavity: an uncommon but still a live issue. 61
26366156 2015
27
Oral tuberculosis lesions. 61
26114686 2015
28
Synchronous oral paracoccidioidomycosis and pulmonary tuberculosis in an immunocompetent patient. 61
25652419 2015
29
Tuberculosis of the oral cavity. 61
26193222 2015
30
[DEYCKE PASHA AND THE LÜBECK DISASTER]. 61
30717502 2015
31
Tuberculosis: oral alveolus and pulmonary alveoli coexisting. 61
25477361 2014
32
Orofacial tubercular lesions. 61
25675696 2014
33
Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis. 61
24820085 2014
34
Oropharyngeal and miliary pulmonary tuberculosis without respiratory symptom. 61
25427355 2014
35
Primary labial tuberculosis: a rare presentation. 61
24669346 2014
36
Common opportunistic infections and their CD4 cell correlates among HIV-infected patients attending at antiretroviral therapy clinic of Gondar University Hospital, Northwest Ethiopia. 61
24330921 2013
37
Primary oral tuberculosis. 61
23907970 2013
38
Tuberculosis of oral cavity: a series of one primary and three secondary cases. 61
24427581 2013
39
Primary oral tuberculosis in a sexagenarian female. 61
23761494 2013
40
Oral tuberculosis: a tongue case report. 61
23756837 2013
41
Tuberculosis, the culprit behind nonhealing oral lesions: report of two cases. 61
23897523 2012
42
Oral tuberculosis following successful treatment of oral malignancy. 61
23361293 2012
43
[Tuberculosis in the dental office. Epidemiology, clinical view and prevention]. 61
22567814 2012
44
Primary tuberculosis: an unusual finding in the oral cavity. 61
22488029 2012
45
Tuberculoma of the tongue presenting as hemimacroglossia. 61
23319955 2012
46
Lingual tuberculosis. 61
22670511 2012
47
Primary oral tuberculosis. 61
22143859 2011
48
Tuberculosis masquerading as oral malignancy. 61
22557791 2011
49
Oral tuberculosis involving maxillary gingiva. 61
22639508 2011
50
Oral tuberculosis: unusual radiographic findings. 61
21493882 2011

Variations for Oral Tuberculosis

Expression for Oral Tuberculosis

Search GEO for disease gene expression data for Oral Tuberculosis.

Pathways for Oral Tuberculosis

Pathways related to Oral Tuberculosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 TNF IL2 IFNG CD4
2
Show member pathways
12.45 TNF IL2 IFNG CD4
3
Show member pathways
12.44 TNF IL2 IFNG CD4
4
Show member pathways
12.43 TNF IL2 IFNG CD8A CD4
5 12.41 TNF IL2 IFNG CD8A
6
Show member pathways
12.36 TNF PRF1 IL2 IFNG
7
Show member pathways
12.17 TNF MMUT IL2 IFNG CRP
8
Show member pathways
11.97 TNF PRF1 IL2 IFNG GNLY CD8A
9 11.95 TNF IL2 CD8A CD4
10 11.88 TNF IL2 IFNG
11 11.87 TNF IL2 IFNG CD8A CD4
12
Show member pathways
11.83 PRF1 CD8A CD4
13
Show member pathways
11.83 IL2 IFNG CD8A CD4
14 11.76 TNF CD8A CD4
15
Show member pathways
11.64 TNF IL2 IFNG CD4
16
Show member pathways
11.63 TNF IL2 IFNG
17 11.56 TNF IL2 IFNG CD8A CD4
18
Show member pathways
11.54 TNF IL2 IFNG
19 11.44 TNF IL2 IFNG
20 11.42 TNF IL2 IFNG CD8A CD4
21 11.4 TNF IL2 IFNG
22 11.38 IL2 IFNG CD4
23
Show member pathways
11.26 TNF IL2 IFNG
24
Show member pathways
11.14 TNF PRF1 IL2 IFNG CD8A
25 11.13 TNF IL2 IFNG CD4
26 11.07 PRF1 IL2 IFNG CD4
27 10.91 TNF CRP

GO Terms for Oral Tuberculosis

Cellular components related to Oral Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNF PRF1 IL2 IFNG GNLY CRP
2 cytolytic granule GO:0044194 8.62 PRF1 GNLY

Biological processes related to Oral Tuberculosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.65 TNF IL2 IFNG
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 TNF IL2 IFNG
3 positive regulation of amyloid-beta formation GO:1902004 9.55 TNF IFNG
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 TNF IFNG
5 positive regulation of phagocytosis GO:0050766 9.54 TNF IFNG C3
6 astrocyte activation GO:0048143 9.52 TNF IFNG
7 regulation of regulatory T cell differentiation GO:0045589 9.51 IL2 IFNG
8 negative regulation of amyloid-beta clearance GO:1900222 9.49 TNF IFNG
9 negative regulation of lipid storage GO:0010888 9.46 TNF CRP
10 immune response GO:0006955 9.43 TNF IL2 IFNG CD8A CD4 C3
11 positive regulation of killing of cells of other organism GO:0051712 9.4 PRF1 IFNG
12 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IFNG
13 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 TNF IFNG
14 positive regulation of nitrogen compound metabolic process GO:0051173 9.16 TNF IFNG
15 positive regulation of protein phosphorylation GO:0001934 9.02 TNF IL2 IFNG CD4 C3

Sources for Oral Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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