MCID: ORN009
MIFTS: 20

Orange Allergy

Categories: Immune diseases

Aliases & Classifications for Orange Allergy

MalaCards integrated aliases for Orange Allergy:

Name: Orange Allergy 12 15
Citrus Sinensis Fruit Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060508

Summaries for Orange Allergy

Disease Ontology : 12 A fruit allergy triggered by Citrus sinensis plant fruit food product.

MalaCards based summary : Orange Allergy, also known as citrus sinensis fruit allergy, is related to peach allergy and timothy grass allergy. An important gene associated with Orange Allergy is SCP2 (Sterol Carrier Protein 2), and among its related pathways/superpathways are Allograft rejection and Development and heterogeneity of the ILC family.

Related Diseases for Orange Allergy

Diseases related to Orange Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 peach allergy 10.4 SCP2 PDCL
2 timothy grass allergy 10.4 PDCL PDC
3 wheat allergy 10.4 SCP2 PDCL
4 fish allergy 10.3 PVALB PDCL
5 aspirin allergy 10.3 WDFY2 TPO
6 tomato allergy 10.2 SCP2 PDCL PDC
7 apple allergy 10.2 SCP2 PDCL PDC
8 fruit allergy 10.2 SCP2 PDCL PDC
9 diabetes mellitus, insulin-dependent, 20 10.1 TPO DACT1
10 crab allergy 10.1 PVALB PDCL PDC
11 melon allergy 10.1 PVALB PDCL PDC
12 microcephaly and chorioretinopathy 1 10.1 TPO TBL1X
13 methylmalonic aciduria, cbla type 10.1 TPO TBL1X
14 balantidiasis 10.1 TPO TBL1X
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TPO FOXP3
16 spinocerebellar ataxia 29 9.9 TPO TBL1X
17 aneruptive fever 9.8 IL13 FOXP3
18 cow milk allergy 9.8 IL5 FOXP3
19 egg allergy 9.8 PDCL IL5 FOXP3
20 cytokine deficiency 9.8 IL5 IL13
21 aztreonam allergy 9.7 IL5 IL13
22 ceftriaxone allergy 9.7 IL5 IL13
23 angioimmunoblastic lymphadenopathy with dysproteinemia 9.7 IL5 IL13
24 respiratory syncytial virus infectious disease 9.7 IL5 IL13
25 cefaclor allergy 9.7 IL5 IL13
26 cefuroxime allergy 9.7 IL5 IL13
27 loeffler syndrome 9.7 IL5 IL13
28 norwegian scabies 9.7 IL5 IL13
29 dacryoadenitis 9.7 IL13 FOXP3
30 eosinophilic gastritis 9.7 IL5 IL13
31 loiasis 9.7 IL5 IL13
32 trichinosis 9.7 IL5 IL13
33 mikulicz disease 9.7 IL5 IL13
34 vernal keratoconjunctivitis 9.7 IL5 IL13
35 stevens-johnson syndrome/toxic epidermal necrolysis 9.7 IL5 IL13
36 intrinsic asthma 9.7 IL5 IL13
37 paragonimiasis 9.7 IL5 IL13
38 angiostrongyliasis 9.7 IL5 IL13
39 chronic rhinitis 9.6 IL5 IL13
40 chronic conjunctivitis 9.6 IL5 IL13
41 strongyloidiasis 9.6 IL5 IL13
42 eosinophilic meningitis 9.6 IL5 IL13
43 hashimoto thyroiditis 9.6 TPO IL5 FOXP3
44 conjunctival disease 9.5 PDCL IL5 IL13
45 kimura disease 9.5 IL5 IL13
46 filarial elephantiasis 9.5 IL5 IL13
47 intestinal schistosomiasis 9.5 IL5 IL13
48 alopecia areata 9.5 TPO IL13 FOXP3
49 ascaris lumbricoides infection 9.4 IL5 IL13
50 milk allergy 9.4 IL5 IL13 FOXP3

Graphical network of the top 20 diseases related to Orange Allergy:



Diseases related to Orange Allergy

Symptoms & Phenotypes for Orange Allergy

Drugs & Therapeutics for Orange Allergy

Search Clinical Trials , NIH Clinical Center for Orange Allergy

Genetic Tests for Orange Allergy

Anatomical Context for Orange Allergy

Publications for Orange Allergy

Articles related to Orange Allergy:

# Title Authors PMID Year
1
Identification of gibberellin-regulated protein as a new allergen in orange allergy. 61
30099793 2018
2
Development of monoclonal antibody-based ELISA for the quantification of orange allergen Cit s 2 in fresh and processed oranges. 61
28490094 2017
3
Lipid transfer proteins and allergy to oranges. 61
15947476 2005

Variations for Orange Allergy

Expression for Orange Allergy

Search GEO for disease gene expression data for Orange Allergy.

Pathways for Orange Allergy

Pathways related to Orange Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 TPO IL5 IL13 FOXP3
2 10.83 IL5 IL13
3 10.62 IL5 IL13
4 10.46 IL5 IL13 FOXP3
5 10.37 IL5 IL13

GO Terms for Orange Allergy

Biological processes related to Orange Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of Wnt signaling pathway GO:0030111 9.4 FOXP3 DACT1
2 phosphatidylcholine acyl-chain remodeling GO:0036151 9.37 PLA2G2A PLA2G1B
3 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.32 PLA2G2A PLA2G1B
4 arachidonic acid secretion GO:0050482 9.26 PLA2G2A PLA2G1B
5 phosphatidylserine acyl-chain remodeling GO:0036150 9.16 PLA2G2A PLA2G1B
6 phosphatidylinositol acyl-chain remodeling GO:0036149 8.96 PLA2G2A PLA2G1B
7 phosphatidylglycerol acyl-chain remodeling GO:0036148 8.62 PLA2G2A PLA2G1B

Molecular functions related to Orange Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipase A2 activity GO:0004623 9.26 PLA2G2A PLA2G1B
2 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) GO:0102568 9.16 PLA2G2A PLA2G1B
3 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) GO:0102567 8.96 PLA2G2A PLA2G1B
4 calcium-dependent phospholipase A2 activity GO:0047498 8.62 PLA2G2A PLA2G1B

Sources for Orange Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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