MCID: ORB009
MIFTS: 32

Orbit Lymphoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Orbit Lymphoma

MalaCards integrated aliases for Orbit Lymphoma:

Name: Orbit Lymphoma 12 15
Orbital Lymphoma 44 70
Lymphoma of the Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9986
MeSH 44 C537131
NCIt 50 C6244
SNOMED-CT 67 13048006
UMLS 70 C0271333

Summaries for Orbit Lymphoma

Disease Ontology : 12 An orbital cancer that has material basis in some lymphocyte.

MalaCards based summary : Orbit Lymphoma, also known as orbital lymphoma, is related to diffuse large b-cell lymphoma and mature t-cell and nk-cell lymphoma. An important gene associated with Orbit Lymphoma is NCAM1 (Neural Cell Adhesion Molecule 1), and among its related pathways/superpathways are NF-kappaB Signaling and TCR signaling in naive CD4+ T cells. Affiliated tissues include eye, spleen and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Orbit Lymphoma

Diseases related to Orbit Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 diffuse large b-cell lymphoma 30.0 MALT1 FOXP1 BCL10
2 mature t-cell and nk-cell lymphoma 29.8 TIA1 NCAM1
3 peripheral t-cell lymphoma 29.7 TIA1 NCAM1
4 central nervous system lymphoma 29.7 MALT1 FOXP1
5 lymphoma 29.7 TIA1 MALT1 BIRC3 BCL10
6 lymphoma, non-hodgkin, familial 29.7 NCAM1 MALT1 BIRC3 BCL10
7 lymphoma, mucosa-associated lymphoid type 29.6 MALT1 FOXP1 BIRC3 BCL10
8 marginal zone b-cell lymphoma 29.5 MALT1 FOXP1 BIRC3 BCL10
9 leukemia, chronic lymphocytic 29.2 NCAM1 BIRC3 BCL10
10 b-cell lymphoma 29.2 TIA1 MALT1 FOXP1 BIRC3 BCL10
11 orbital lymphoma 11.3
12 exophthalmos 10.3
13 lymphoma, hodgkin, classic 10.3
14 nodal marginal zone lymphoma 10.2
15 reticulum cell sarcoma 10.1
16 follicular lymphoma 10.1
17 ptosis 10.1
18 lymphoblastic lymphoma 10.1
19 cll/sll 10.1
20 graves' disease 10.1
21 conjunctivitis 10.1
22 cataract 10.1
23 primary cutaneous marginal zone b-cell lymphoma 10.0 MALT1 BCL10
24 keratitis, hereditary 10.0
25 yemenite deaf-blind hypopigmentation syndrome 10.0
26 xerophthalmia 10.0
27 keratoconjunctivitis sicca 10.0
28 optic nerve disease 10.0
29 hyperthyroidism 10.0
30 orbital disease 10.0
31 b-cell non-hodgkin lymphoma 10.0
32 phaeohyphomycosis 10.0 MALT1 BCL10
33 gallbladder lymphoma 10.0 MALT1 BIRC3
34 plasma cell leukemia 10.0 NCAM1 BCL10
35 immunodeficiency 11 10.0 MALT1 BCL10
36 spleen cancer 10.0 MALT1 BIRC3
37 leukocyte disease 9.9 NCAM1 MALT1
38 autoimmune disease 9.9
39 burkitt lymphoma 9.9
40 sarcoidosis 1 9.9
41 immune deficiency disease 9.9
42 kearns-sayre syndrome 9.9
43 proteinuria, chronic benign 9.9
44 exanthem 9.9
45 mantle cell lymphoma 9.9
46 lymphoplasmacytic lymphoma 9.9
47 plasmablastic lymphoma 9.9
48 nasal type extranodal nk/t-cell lymphoma 9.9
49 rapidly involuting congenital hemangioma 9.9
50 orbital cellulitis 9.9

Graphical network of the top 20 diseases related to Orbit Lymphoma:



Diseases related to Orbit Lymphoma

Symptoms & Phenotypes for Orbit Lymphoma

GenomeRNAi Phenotypes related to Orbit Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 8.8 BCL10 BIRC3
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 8.8 BCL10

Drugs & Therapeutics for Orbit Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lymphoma in the Orbit Unknown status NCT01302912

Search NIH Clinical Center for Orbit Lymphoma

Cochrane evidence based reviews: orbital lymphoma

Genetic Tests for Orbit Lymphoma

Anatomical Context for Orbit Lymphoma

MalaCards organs/tissues related to Orbit Lymphoma:

40
Eye, Spleen, Kidney

Publications for Orbit Lymphoma

Articles related to Orbit Lymphoma:

(show top 50) (show all 255)
# Title Authors PMID Year
1
[Secondary eyelid pockets: Pitfalls in blepharoplasty surgery]. 61
33516573 2021
2
Henoch-Schönlein Purpura Associated With Diffuse Large B-cell Lymphoma of the Orbit. 61
32675722 2021
3
Arterial spin labeling and diffusion-weighted MR imaging: Utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma. 61
33171369 2021
4
The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms. 61
33125778 2021
5
Lymphoma and inflammatory disorders presenting in the orbit- a comparison of characteristics from a 10-year series in a tertiary hospital. 61
33645420 2021
6
Initial Manifestation of Orbital Lymphomas: The Role of Early Diagnosis. 61
33645951 2021
7
Intravoxel incoherent motion (IVIM) 3 T MRI for orbital lesion characterization. 61
32740820 2021
8
To Explore MR Imaging Radiomics for the Differentiation of Orbital Lymphoma and IgG4-Related Ophthalmic Disease. 61
33628805 2021
9
Role of Quantitative Spectral CT Analysis for Differentiation of Orbital Lymphoma and Other Orbital Lymphoproliferative Disease. 61
33130359 2020
10
Epidemiology, outcomes, and prognostic factors of orbital lymphoma in the United States. 61
31894706 2020
11
Inferior Divisional Oculomotor Nerve Palsy Due to Orbital Lymphoma. 61
33029984 2020
12
[Use of the Multidisciplinary Specialised Case Conference at the Freiburg Orbital Centre]. 61
32016941 2020
13
Nationwide trends in the incidence of orbital lymphoma from 1999 to 2016 in South Korea. 61
32863278 2020
14
Evolution of Care of Orbital Tumors with Radiation Therapy. 61
33072488 2020
15
Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit. 61
32751135 2020
16
cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation. 61
31841217 2020
17
Orbital Lymphoma mimicking non-resolving dacryocystitis. 61
31948686 2020
18
Clinical Analysis of Castleman's Disease of the Lacrimal Gland. 61
33489328 2020
19
Transcatheter arterial embolization of an orbital lymphoma. 61
33542994 2020
20
A pan-inflammatory microRNA-cluster is associated with orbital non-Hodgkin lymphoma and idiopathic orbital inflammation. 61
31713839 2020
21
Orbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular Glaucoma. 61
31593042 2020
22
Ocular Complications After Radiation Therapy: An Observational Study. 61
33116366 2020
23
Orbital Lymphoma Presenting with Inferior Rectus Palsy. 61
31286714 2019
24
Prevalence of a Histologic Change of Ocular Adnexal Lymphoma in Patients With a History of Lymphoma. 61
30124609 2019
25
Orbital Lymphoma-An International Multicenter Retrospective Study. 61
30419193 2019
26
Primary lacrimal sac diffuse large B-cell lymphoma in a child. 61
30391376 2019
27
[Orbital lymphoma in a rare location : Case report of optic neuropathy]. 61
30679125 2019
28
Orbital lymphoma. 61
30144455 2019
29
[Clinical features of malignant orbital lymphoma]. 61
31714507 2019
30
Subconjunctival Orbital Fat Prolapse: An Update on Diagnosis and Management. 61
30741060 2019
31
[Bilateral pseudotumoral proptosis as presenting sign of orbital hyper-IgG4-related disease]. 61
29887405 2018
32
[Clinical, radiological, pathological features, treatment and follow-up of periocular and/or orbital amyloidosis: Report of 6 cases and literature review]. 61
29954616 2018
33
Waldenstrom macroglobulinemia involving the superior rectus muscle. 61
29780960 2018
34
Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. 61
29716527 2018
35
Transient reversal of macular ischemia with intravitreal steroid implant injection in a case of radiation maculopathy. 61
29480273 2018
36
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases. 61
28364339 2018
37
A large primary orbital lymphoma with proptosis: A case report and review. 61
30603233 2018
38
Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques. 61
28779398 2018
39
Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature. 61
32300410 2018
40
Radiotherapy in the Management of Orbital Lymphoma: A Single Institution's Experience Over 4 Decades. 61
26398063 2018
41
Early Onset Multiple Primary Tumors in Atypical Presentation of Cowden Syndrome Identified by Whole-Exome-Sequencing. 61
30233642 2018
42
The treatment results in patients with lmphoma disease in the orbit. 61
30541302 2018
43
Cognitive biases in orbital mass lesions - Lessons learned. 61
29755267 2018
44
Meibomian Gland Dysfunction Associated With Periocular Radiotherapy. 61
28902011 2017
45
Retrospective chart review of the use of imaging and biopsy in the diagnosis of optic nerve sheath meningiomas and intra-conal orbital lymphomas at a single institution. 61
28812914 2017
46
Orbital mantle cell lymphoma presenting as myasthenia gravis. 61
28820310 2017
47
Primary orbital lymphoma: A case report and review of the literature. 61
29102049 2017
48
Optic Nerve Infiltration in Primary Central Nervous System Lymphoma. 61
28973119 2017
49
[Orbital lymphoma masquerading in a young patient with Graves ophthalmopathy]. 61
28889905 2017
50
A Rare Case of Aggressive, Huge Primary Orbital Lymphoma with Intracranial Extension and Bone Invasion. 61
29114307 2017

Variations for Orbit Lymphoma

Expression for Orbit Lymphoma

Search GEO for disease gene expression data for Orbit Lymphoma.

Pathways for Orbit Lymphoma

Pathways related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 NCAM1 MALT1 BCL10
2
Show member pathways
11.36 MALT1 BCL10
3 11.19 TIA1 MALT1 BIRC3 BCL10
4 11.15 MALT1 BIRC3 BCL10
5 10.52 MALT1 BCL10

GO Terms for Orbit Lymphoma

Cellular components related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CBM complex GO:0032449 8.96 MALT1 BCL10
2 polkadots GO:0002096 8.62 MALT1 BCL10

Biological processes related to Orbit Lymphoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.58 MALT1 BIRC3 BCL10
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.49 MALT1 BCL10
3 regulation of inflammatory response GO:0050727 9.48 FOXP1 BIRC3
4 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.46 BIRC3 BCL10
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.43 MALT1 BCL10
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.43 MALT1 BIRC3 BCL10
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.37 MALT1 BCL10
8 positive regulation of T cell activation GO:0050870 9.32 MALT1 BCL10
9 regulation of T cell receptor signaling pathway GO:0050856 9.16 MALT1 BCL10
10 response to fungus GO:0009620 8.96 MALT1 BCL10
11 positive regulation of protein ubiquitination GO:0031398 8.8 MALT1 BIRC3 BCL10

Molecular functions related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.16 MALT1 BCL10
2 kinase activator activity GO:0019209 8.96 MALT1 BCL10
3 protein self-association GO:0043621 8.8 MALT1 FOXP1 BCL10

Sources for Orbit Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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