MCID: ORB009
MIFTS: 26

Orbit Lymphoma

Categories: Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Orbit Lymphoma

MalaCards integrated aliases for Orbit Lymphoma:

Name: Orbit Lymphoma 12 15
Orbital Lymphoma 44 73
Lymphoma of the Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9986
MeSH 44 C537131
NCIt 50 C6244
SNOMED-CT 68 13048006
UMLS 73 C0271333

Summaries for Orbit Lymphoma

MalaCards based summary : Orbit Lymphoma, also known as orbital lymphoma, is related to orbital lymphoma and lymphoma. An important gene associated with Orbit Lymphoma is NCAM1 (Neural Cell Adhesion Molecule 1), and among its related pathways/superpathways are Apoptosis and Autophagy and Innate Lymphoid Cell Differentiation Pathways. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Orbit Lymphoma

Diseases related to Orbit Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 orbital lymphoma 12.4
2 lymphoma 10.3
3 lethal midline granuloma 10.0 NCAM1 TIA1
4 parasitic ichthyosporea infectious disease 9.9 NCAM1 TIA1
5 rhinosporidiosis 9.9 NCAM1 TIA1
6 lichen sclerosus et atrophicus 9.7 GZMB TIA1
7 lymphomatoid granulomatosis 9.6 GZMB TIA1
8 viral esophagitis 9.6 GZMB TIA1
9 lymphocytic gastritis 9.6 GZMB TIA1
10 primary cutaneous anaplastic large cell lymphoma 9.6 GZMB TIA1
11 t-cell large granular lymphocyte leukemia 9.6 GZMB NCAM1
12 natural killer cell leukemia 9.6 GZMB TIA1
13 composite lymphoma 9.6 GZMB TIA1
14 hepatosplenic t-cell lymphoma 9.6 GZMB TIA1
15 autoimmune lymphoproliferative syndrome, type v 9.6
16 intraocular lymphoma 9.6
17 enophthalmos 9.6
18 panuveitis 9.6
19 graves' disease 9.6
20 central retinal artery occlusion 9.6
21 uveitis 9.6
22 scleritis 9.6
23 retinitis 9.6
24 pleomorphic adenoma 9.6
25 adenoma 9.6
26 retinal artery occlusion 9.6
27 hypopituitarism 9.6
28 lymphomatoid papulosis 9.5 GZMB TIA1
29 choriocarcinoma of the testis 9.5 GZMB TIA1
30 lung lymphoma 9.5 GZMB NCAM1
31 giardiasis 9.5 GZMB TIA1
32 infiltrating lipoma 9.5 GZMB TIA1
33 necrotizing sialometaplasia 9.4 GZMB TIA1
34 reticulosarcoma 9.4 GZMB TIA1
35 b-cell expansion with nfkb and t-cell anergy 9.3 GZMB TIA1
36 lymphoma, hodgkin, classic 9.2 GZMB TIA1
37 cutaneous t cell lymphoma 9.1 GZMB TIA1
38 subcutaneous panniculitis-like t-cell lymphoma 9.1 GZMB NCAM1 TIA1
39 panniculitis 9.0 GZMB NCAM1 TIA1
40 peripheral t-cell lymphoma 9.0 GZMB NCAM1 TIA1
41 mycosis fungoides 8.9 GZMB TIA1

Graphical network of the top 20 diseases related to Orbit Lymphoma:



Diseases related to Orbit Lymphoma

Symptoms & Phenotypes for Orbit Lymphoma

Drugs & Therapeutics for Orbit Lymphoma

Drugs for Orbit Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Not Applicable 174722-31-7 10201696
2 Antibodies Not Applicable
3 Immunoglobulins Not Applicable
4 Antibodies, Monoclonal Not Applicable
5 Antirheumatic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lymphoma in the Orbit Unknown status NCT01302912
2 Radioimmunotherapy With 90Y Zevalin for Orbital Lymphoma Completed NCT00387023 Not Applicable Rituximab;Zevalin
3 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Active, not recruiting NCT01443000

Search NIH Clinical Center for Orbit Lymphoma

Cochrane evidence based reviews: orbital lymphoma

Genetic Tests for Orbit Lymphoma

Anatomical Context for Orbit Lymphoma

MalaCards organs/tissues related to Orbit Lymphoma:

41
Bone

Publications for Orbit Lymphoma

Articles related to Orbit Lymphoma:

(show all 30)
# Title Authors Year
1
Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. ( 29716527 )
2018
2
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases. ( 28364339 )
2017
3
A Rare Case of Aggressive, Huge Primary Orbital Lymphoma with Intracranial Extension and Bone Invasion. ( 29114307 )
2017
4
A correlation study between IgH gene rearrangement and orbital lymphoma removal operation prognosis. ( 28678330 )
2017
5
Primary orbital lymphoma: A case report and review of the literature. ( 29102049 )
2017
6
Bilateral orbital lymphoma presenting as recurrence of orbital fat pad after blepharoplasty. ( 28237175 )
2017
7
Orbital lymphoma with isolated occult bilateral adrenal involvement: report of an extremely rare case. ( 27151724 )
2016
8
Partial orbit irradiation achieves excellent outcomes for primary orbital lymphoma. ( 26935235 )
2016
9
Spontaneous regression of orbital lymphoma. ( 27146729 )
2016
10
Outcome of primary orbital lymphoma treated with induction chemotherapy followed by conformal radiotherapy. ( 25935857 )
2015
11
Outcomes of primary lymphoma of the ocular adnexa (orbital lymphoma) treated with radiotherapy. ( 25455843 )
2015
12
Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy. ( 25356924 )
2015
13
Radiotherapy in the Management of Orbital Lymphoma: A Single Institution's Experience Over 4 Decades. ( 26398063 )
2015
14
Teaching NeuroImages: Superior divisional oculomotor nerve palsy due to orbital lymphoma. ( 26150599 )
2015
15
Uveitis masquerade syndrome and orbital lymphoma: two challenging diagnosis. ( 24771150 )
2014
16
Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. ( 24874530 )
2014
17
Orbital lymphoma associated with Graves' disease: A case report. ( 26137719 )
2014
18
Radiotherapy in orbital lymphoma: optimizing the backbone to build upon. ( 22967002 )
2013
19
Orbital lymphoma: diagnostic approach and treatment outcome. ( 23506357 )
2013
20
Orbital lymphoma mimicking lacrimal gland pleomorphic adenoma. ( 24163677 )
2013
21
Low-dose radiation therapy (2 Gy A9 2) in the treatment of orbital lymphoma. ( 23726002 )
2013
22
Orbital lymphoma: imaging features and differential diagnosis. ( 22695946 )
2012
23
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma. ( 22521959 )
2012
24
Orbital lymphoma mimicking ophthalmopathy in a patient with Graves'. ( 22885624 )
2012
25
Orbital lymphoma masquerading as panuveitis. ( 20482392 )
2010
26
Bilateral simultaneous primary orbital lymphoma presenting with unilateral enophthalmos. ( 18356723 )
2008
27
Orbital lymphoma misdiagnosed as scleritis. ( 12466182 )
2002
28
Hypopituitarism and nesidioblastosis in an elderly patient with orbital lymphoma. ( 11911041 )
2002
29
Central retinal artery occlusion due to rapidly expanding orbital lymphoma. ( 9614542 )
1998
30
Orbital lymphoma in a patient with Felty's syndrome. ( 1540565 )
1992

Variations for Orbit Lymphoma

Expression for Orbit Lymphoma

Search GEO for disease gene expression data for Orbit Lymphoma.

Pathways for Orbit Lymphoma

Pathways related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 GZMB TIA1
2 10.53 GZMB NCAM1

GO Terms for Orbit Lymphoma

Sources for Orbit Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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