MCID: ORB009
MIFTS: 31

Orbit Lymphoma

Categories: Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Orbit Lymphoma

MalaCards integrated aliases for Orbit Lymphoma:

Name: Orbit Lymphoma 12 15
Orbital Lymphoma 44 73
Lymphoma of the Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9986
MeSH 44 C537131
NCIt 50 C6244
SNOMED-CT 68 13048006
UMLS 73 C0271333

Summaries for Orbit Lymphoma

MalaCards based summary : Orbit Lymphoma, also known as orbital lymphoma, is related to composite lymphoma and peripheral t-cell lymphoma. An important gene associated with Orbit Lymphoma is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and t cells.

Related Diseases for Orbit Lymphoma

Diseases related to Orbit Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 composite lymphoma 29.5 GZMB TIA1
2 peripheral t-cell lymphoma 29.1 GZMB NCAM1 TIA1
3 orbital lymphoma 12.6
4 lymphoma 10.7
5 b-cell lymphomas 10.1
6 lethal midline granuloma 10.0 NCAM1 TIA1
7 parasitic ichthyosporea infectious disease 10.0 NCAM1 TIA1
8 rhinosporidiosis 10.0 NCAM1 TIA1
9 lichen sclerosus et atrophicus 9.9 GZMB TIA1
10 lymphomatoid granulomatosis 9.9 GZMB TIA1
11 viral esophagitis 9.9 GZMB TIA1
12 lymphatic system cancer 9.9 NCAM1 TIA1
13 lymphocytic gastritis 9.9 GZMB TIA1
14 acquired immunodeficiency syndrome 9.9
15 primary cutaneous anaplastic large cell lymphoma 9.9 GZMB TIA1
16 hepatosplenic t-cell lymphoma 9.9 GZMB TIA1
17 lymphomatoid papulosis 9.9 GZMB TIA1
18 choriocarcinoma of the testis 9.9 GZMB TIA1
19 giardiasis 9.9 GZMB TIA1
20 lymphoma, hodgkin, classic 9.9
21 lymphoma, non-hodgkin, familial 9.9
22 diffuse large b-cell lymphoma 9.9
23 lymphoblastic lymphoma 9.9
24 marginal zone b-cell lymphoma 9.9
25 nodal marginal zone lymphoma 9.9
26 infiltrating lipoma 9.9 GZMB TIA1
27 necrotizing sialometaplasia 9.9 GZMB TIA1
28 t-cell large granular lymphocyte leukemia 9.8 GZMB NCAM1
29 angioimmunoblastic t-cell lymphoma 9.8 GZMB TIA1
30 lung lymphoma 9.8 GZMB NCAM1
31 reticulosarcoma 9.8 GZMB TIA1
32 b-cell expansion with nfkb and t-cell anergy 9.8 GZMB TIA1
33 cutaneous t cell lymphoma 9.8 GZMB TIA1
34 burkitt lymphoma 9.7
35 lymphoma, mucosa-associated lymphoid type 9.7
36 reticulum cell sarcoma 9.7
37 sarcoma 9.7
38 orbital cellulitis 9.7
39 tolosa-hunt syndrome 9.7
40 cellulitis 9.7
41 lymphosarcoma 9.7
42 plasmablastic lymphoma 9.7
43 t-cell/histiocyte rich large b cell lymphoma 9.7
44 subcutaneous panniculitis-like t-cell lymphoma 9.7 GZMB NCAM1 TIA1
45 panniculitis 9.7 GZMB NCAM1 TIA1
46 natural killer cell leukemia 9.7 GZMB NCAM1 TIA1
47 ileum cancer 9.7 GZMB NCAM1 TIA1
48 mycosis fungoides 9.7 GZMB TIA1
49 rheumatoid arthritis 9.7
50 sjogren syndrome 9.7

Graphical network of the top 20 diseases related to Orbit Lymphoma:



Diseases related to Orbit Lymphoma

Symptoms & Phenotypes for Orbit Lymphoma

Drugs & Therapeutics for Orbit Lymphoma

Drugs for Orbit Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Not Applicable 174722-31-7 10201696
2 Antibodies Not Applicable
3 Antibodies, Monoclonal Not Applicable
4 Immunoglobulins Not Applicable
5 Antirheumatic Agents Not Applicable
6 Immunologic Factors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lymphoma in the Orbit Unknown status NCT01302912
2 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Unknown status NCT01443000
3 Radioimmunotherapy With 90Y Zevalin for Orbital Lymphoma Completed NCT00387023 Not Applicable Rituximab;Zevalin

Search NIH Clinical Center for Orbit Lymphoma

Cochrane evidence based reviews: orbital lymphoma

Genetic Tests for Orbit Lymphoma

Anatomical Context for Orbit Lymphoma

MalaCards organs/tissues related to Orbit Lymphoma:

41
Bone, Thyroid, T Cells, B Cells, Lung, Testis

Publications for Orbit Lymphoma

Articles related to Orbit Lymphoma:

(show top 50) (show all 116)
# Title Authors Year
1
Orbital lymphoma. ( 30144455 )
2019
2
Orbital Lymphoma - An International Multicenter Retrospective Study. ( 30419193 )
2018
3
Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. ( 29716527 )
2018
4
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases. ( 28364339 )
2017
5
A Rare Case of Aggressive, Huge Primary Orbital Lymphoma with Intracranial Extension and Bone Invasion. ( 29114307 )
2017
6
A correlation study between IgH gene rearrangement and orbital lymphoma removal operation prognosis. ( 28678330 )
2017
7
Primary orbital lymphoma: A case report and review of the literature. ( 29102049 )
2017
8
Bilateral orbital lymphoma presenting as recurrence of orbital fat pad after blepharoplasty. ( 28237175 )
2017
9
Orbital lymphoma with isolated occult bilateral adrenal involvement: report of an extremely rare case. ( 27151724 )
2016
10
Partial orbit irradiation achieves excellent outcomes for primary orbital lymphoma. ( 26935235 )
2016
11
Spontaneous regression of orbital lymphoma. ( 27146729 )
2016
12
Outcome of primary orbital lymphoma treated with induction chemotherapy followed by conformal radiotherapy. ( 25935857 )
2015
13
Outcomes of primary lymphoma of the ocular adnexa (orbital lymphoma) treated with radiotherapy. ( 25455843 )
2015
14
Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy. ( 25356924 )
2015
15
Radiotherapy in the Management of Orbital Lymphoma: A Single Institution's Experience Over 4 Decades. ( 26398063 )
2015
16
Teaching NeuroImages: Superior divisional oculomotor nerve palsy due to orbital lymphoma. ( 26150599 )
2015
17
Uveitis masquerade syndrome and orbital lymphoma: two challenging diagnosis. ( 24771150 )
2014
18
Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. ( 24874530 )
2014
19
Orbital lymphoma associated with Graves' disease: A case report. ( 26137719 )
2014
20
Radiotherapy in orbital lymphoma: optimizing the backbone to build upon. ( 22967002 )
2013
21
Orbital lymphoma: diagnostic approach and treatment outcome. ( 23506357 )
2013
22
Orbital lymphoma mimicking lacrimal gland pleomorphic adenoma. ( 24163677 )
2013
23
Low-dose radiation therapy (2 Gy A9 2) in the treatment of orbital lymphoma. ( 23726002 )
2013
24
Blepharoplasty revealing orbital lymphoma. ( 22214799 )
2013
25
Orbital lymphoma: imaging features and differential diagnosis. ( 22695946 )
2012
26
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma. ( 22521959 )
2012
27
Orbital lymphoma mimicking ophthalmopathy in a patient with Graves'. ( 22885624 )
2012
28
Orbital lymphoma in the setting of idiopathic CD4+ lymphocytopenia (HIV-negative AIDS). ( 21242846 )
2011
29
Intralesional administration of rituximab for treatment of CD20 positive orbital lymphoma: safety and efficacy evaluation. ( 21334067 )
2011
30
What is your neurologic diagnosis? Orbital lymphoma of the T-cell origin. ( 21801041 )
2011
31
Conjunctival and orbital lymphoma. ( 21813098 )
2011
32
An orbital lymphoma involving the pterygopalatine and infratemporal fossae. A case report. ( 24059901 )
2011
33
Orbital lymphoma masquerading as panuveitis. ( 20482392 )
2010
34
Marginal zone B-cell orbital lymphoma with intracranial involvement. ( 20489547 )
2010
35
Orbital lymphoma presenting with choroidal detachments. ( 20683375 )
2010
36
Stereotactic radiotherapy for unilateral orbital lymphoma and orbital pseudo-tumors: a planning study. ( 19181257 )
2009
37
Orbital lymphoma: role of radiation. ( 19237780 )
2009
38
Orbital lymphoma masquerading as thyroid-associated orbitopathy. ( 19734444 )
2009
39
Unusual orbital lymphoma undetectable by magnetic resonance imaging: a case report. ( 19946582 )
2009
40
Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis. ( 19968864 )
2009
41
Bilateral simultaneous primary orbital lymphoma presenting with unilateral enophthalmos. ( 18356723 )
2008
42
Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. ( 18434689 )
2008
43
Primary extrasac orbital lymphoma presenting as nasolacrimal obstruction. ( 18569823 )
2008
44
Orbital lymphoma presenting as an unstable ocular prosthesis: a salutary lesson. ( 18716973 )
2008
45
Images in clinical medicine. Binocular proptosis in orbital lymphoma. ( 18987365 )
2008
46
Intensity-modulated radiation therapy for orbital lymphoma. ( 19132487 )
2008
47
Sudden onset of herpes zoster following chemotherapy for orbital lymphoma in a HIV positive patient. ( 17206304 )
2007
48
Radiotherapy for orbital lymphoma : outcome and late effects. ( 17225941 )
2007
49
Case report of orbital lymphoma associated with polycystic disease: a coincidence? ( 17474250 )
2007
50
Orbital lymphoma, amyloid, and bone. ( 17544794 )
2007

Variations for Orbit Lymphoma

Expression for Orbit Lymphoma

Search GEO for disease gene expression data for Orbit Lymphoma.

Pathways for Orbit Lymphoma

Pathways related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 GZMB NCAM1
2 11.22 GZMB TIA1
3 10.53 GZMB NCAM1

GO Terms for Orbit Lymphoma

Sources for Orbit Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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