MCID: ORB009
MIFTS: 30

Orbit Lymphoma

Categories: Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Orbit Lymphoma

MalaCards integrated aliases for Orbit Lymphoma:

Name: Orbit Lymphoma 12 15
Orbital Lymphoma 45 74
Lymphoma of the Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9986
MeSH 45 C537131
NCIt 51 C6244
SNOMED-CT 69 13048006
UMLS 74 C0271333

Summaries for Orbit Lymphoma

MalaCards based summary : Orbit Lymphoma, also known as orbital lymphoma, is related to composite lymphoma and peripheral t-cell lymphoma. An important gene associated with Orbit Lymphoma is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs rituximab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and thyroid.

Related Diseases for Orbit Lymphoma

Diseases related to Orbit Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 composite lymphoma 29.6 GZMB TIA1
2 peripheral t-cell lymphoma 29.1 GZMB NCAM1 TIA1
3 orbital lymphoma 12.7
4 lymphoma 10.7
5 lichen sclerosus et atrophicus 10.1 GZMB TIA1
6 lymphomatoid granulomatosis 10.1 GZMB TIA1
7 viral esophagitis 10.0 GZMB TIA1
8 lymphocytic gastritis 10.0 GZMB TIA1
9 lymphoma, hodgkin, classic 10.0
10 lymphoma, non-hodgkin, familial 10.0
11 primary cutaneous anaplastic large cell lymphoma 10.0 GZMB TIA1
12 hepatosplenic t-cell lymphoma 10.0 GZMB TIA1
13 lymphomatoid papulosis 10.0 GZMB TIA1
14 choriocarcinoma of the testis 10.0 GZMB TIA1
15 giardiasis 10.0 GZMB TIA1
16 lethal midline granuloma 10.0 NCAM1 TIA1
17 parasitic ichthyosporea infectious disease 10.0 NCAM1 TIA1
18 infiltrating lipoma 10.0 GZMB TIA1
19 rhinosporidiosis 10.0 NCAM1 TIA1
20 necrotizing sialometaplasia 10.0 GZMB TIA1
21 t-cell large granular lymphocyte leukemia 9.9 GZMB NCAM1
22 acquired immunodeficiency syndrome 9.9
23 angioimmunoblastic t-cell lymphoma 9.9 GZMB TIA1
24 lung lymphoma 9.9 GZMB NCAM1
25 reticulosarcoma 9.9 GZMB TIA1
26 diffuse large b-cell lymphoma 9.9
27 lymphoblastic lymphoma 9.9
28 marginal zone b-cell lymphoma 9.9
29 nodal marginal zone lymphoma 9.9
30 lymphatic system cancer 9.9 NCAM1 TIA1
31 b-cell expansion with nfkb and t-cell anergy 9.8 GZMB TIA1
32 exophthalmos 9.8
33 cutaneous t cell lymphoma 9.8 GZMB TIA1
34 burkitt lymphoma 9.7
35 lymphoma, mucosa-associated lymphoid type 9.7
36 sarcoidosis 1 9.7
37 reticulum cell sarcoma 9.7
38 b-cell lymphomas 9.7
39 sarcoma 9.7
40 orbital cellulitis 9.7
41 tolosa-hunt syndrome 9.7
42 cellulitis 9.7
43 plasmablastic lymphoma 9.7
44 t-cell/histiocyte rich large b cell lymphoma 9.7
45 panniculitis 9.7 GZMB NCAM1 TIA1
46 natural killer cell leukemia 9.7 GZMB NCAM1 TIA1
47 ileum cancer 9.7 GZMB NCAM1 TIA1
48 felty syndrome 9.7
49 hashimoto thyroiditis 9.7
50 rheumatoid arthritis 9.7

Graphical network of the top 20 diseases related to Orbit Lymphoma:



Diseases related to Orbit Lymphoma

Symptoms & Phenotypes for Orbit Lymphoma

Drugs & Therapeutics for Orbit Lymphoma

Drugs for Orbit Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Not Applicable 174722-31-7 10201696
2 Antibodies, Monoclonal Not Applicable
3 Antirheumatic Agents Not Applicable
4 Antineoplastic Agents, Immunological Not Applicable
5 Immunoglobulins Not Applicable
6 Immunologic Factors Not Applicable
7 Antibodies Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lymphoma in the Orbit Unknown status NCT01302912
2 Radioimmunotherapy With 90Y Zevalin for Orbital Lymphoma Completed NCT00387023 Not Applicable Rituximab;Zevalin
3 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Completed NCT01443000

Search NIH Clinical Center for Orbit Lymphoma

Cochrane evidence based reviews: orbital lymphoma

Genetic Tests for Orbit Lymphoma

Anatomical Context for Orbit Lymphoma

MalaCards organs/tissues related to Orbit Lymphoma:

42
T Cells, B Cells, Thyroid, Bone, Testis

Publications for Orbit Lymphoma

Articles related to Orbit Lymphoma:

(show top 50) (show all 117)
# Title Authors Year
1
Orbital Lymphoma-An International Multicenter Retrospective Study. ( 30419193 )
2019
2
Orbital lymphoma. ( 30144455 )
2019
3
A large primary orbital lymphoma with proptosis: A case report and review. ( 30603233 )
2018
4
Radiotherapy in the Management of Orbital Lymphoma: A Single Institution's Experience Over 4 Decades. ( 26398063 )
2018
5
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases. ( 28364339 )
2018
6
Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. ( 29716527 )
2018
7
Bilateral orbital lymphoma presenting as recurrence of orbital fat pad after blepharoplasty. ( 28237175 )
2017
8
A correlation study between IgH gene rearrangement and orbital lymphoma removal operation prognosis. ( 28678330 )
2017
9
Primary orbital lymphoma: A case report and review of the literature. ( 29102049 )
2017
10
A Rare Case of Aggressive, Huge Primary Orbital Lymphoma with Intracranial Extension and Bone Invasion. ( 29114307 )
2017
11
Partial orbit irradiation achieves excellent outcomes for primary orbital lymphoma. ( 26935235 )
2016
12
Spontaneous regression of orbital lymphoma. ( 27146729 )
2016
13
Orbital lymphoma with isolated occult bilateral adrenal involvement: report of an extremely rare case. ( 27151724 )
2016
14
Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy. ( 25356924 )
2015
15
Outcomes of primary lymphoma of the ocular adnexa (orbital lymphoma) treated with radiotherapy. ( 25455843 )
2015
16
Outcome of primary orbital lymphoma treated with induction chemotherapy followed by conformal radiotherapy. ( 25935857 )
2015
17
Teaching NeuroImages: Superior divisional oculomotor nerve palsy due to orbital lymphoma. ( 26150599 )
2015
18
Orbital lymphoma associated with Graves' disease: A case report. ( 26137719 )
2014
19
Uveitis masquerade syndrome and orbital lymphoma: two challenging diagnosis. ( 24771150 )
2014
20
Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. ( 24874530 )
2014
21
Blepharoplasty revealing orbital lymphoma. ( 22214799 )
2013
22
Radiotherapy in orbital lymphoma: optimizing the backbone to build upon. ( 22967002 )
2013
23
Orbital lymphoma: diagnostic approach and treatment outcome. ( 23506357 )
2013
24
Low-dose radiation therapy (2 Gy × 2) in the treatment of orbital lymphoma. ( 23726002 )
2013
25
Orbital lymphoma mimicking lacrimal gland pleomorphic adenoma. ( 24163677 )
2013
26
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma. ( 22521959 )
2012
27
Orbital lymphoma: imaging features and differential diagnosis. ( 22695946 )
2012
28
Orbital lymphoma mimicking ophthalmopathy in a patient with Graves'. ( 22885624 )
2012
29
Orbital lymphoma in the setting of idiopathic CD4+ lymphocytopenia (HIV-negative AIDS). ( 21242846 )
2011
30
Intralesional administration of rituximab for treatment of CD20 positive orbital lymphoma: safety and efficacy evaluation. ( 21334067 )
2011
31
What is your neurologic diagnosis? Orbital lymphoma of the T-cell origin. ( 21801041 )
2011
32
Conjunctival and orbital lymphoma. ( 21813098 )
2011
33
An orbital lymphoma involving the pterygopalatine and infratemporal fossae. A case report. ( 24059901 )
2011
34
Orbital lymphoma masquerading as panuveitis. ( 20482392 )
2010
35
Marginal zone B-cell orbital lymphoma with intracranial involvement. ( 20489547 )
2010
36
Orbital lymphoma presenting with choroidal detachments. ( 20683375 )
2010
37
Stereotactic radiotherapy for unilateral orbital lymphoma and orbital pseudo-tumors: a planning study. ( 19181257 )
2009
38
Orbital lymphoma: role of radiation. ( 19237780 )
2009
39
Orbital lymphoma masquerading as thyroid-associated orbitopathy. ( 19734444 )
2009
40
Unusual orbital lymphoma undetectable by magnetic resonance imaging: a case report. ( 19946582 )
2009
41
Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis. ( 19968864 )
2009
42
Bilateral simultaneous primary orbital lymphoma presenting with unilateral enophthalmos. ( 18356723 )
2008
43
Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. ( 18434689 )
2008
44
Primary extrasac orbital lymphoma presenting as nasolacrimal obstruction. ( 18569823 )
2008
45
Orbital lymphoma presenting as an unstable ocular prosthesis: a salutary lesson. ( 18716973 )
2008
46
Images in clinical medicine. Binocular proptosis in orbital lymphoma. ( 18987365 )
2008
47
Intensity-modulated radiation therapy for orbital lymphoma. ( 19132487 )
2008
48
Sudden onset of herpes zoster following chemotherapy for orbital lymphoma in a HIV positive patient. ( 17206304 )
2007
49
Radiotherapy for orbital lymphoma : outcome and late effects. ( 17225941 )
2007
50
Case report of orbital lymphoma associated with polycystic disease: a coincidence? ( 17474250 )
2007

Variations for Orbit Lymphoma

Expression for Orbit Lymphoma

Search GEO for disease gene expression data for Orbit Lymphoma.

Pathways for Orbit Lymphoma

Pathways related to Orbit Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 GZMB NCAM1
2 11.22 GZMB TIA1
3 10.53 GZMB NCAM1

GO Terms for Orbit Lymphoma

Sources for Orbit Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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