MCID: ORB011
MIFTS: 33

Orbit Rhabdomyosarcoma

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Orbit Rhabdomyosarcoma

MalaCards integrated aliases for Orbit Rhabdomyosarcoma:

Name: Orbit Rhabdomyosarcoma 11 14
Rhabdomyosarcoma of the Orbit 11 43 71
Rhabdomyosarcoma of Orbit 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3259
MeSH 43 C537605
NCIt 49 C4543
SNOMED-CT 68 254994000
UMLS 71 C0346347

Summaries for Orbit Rhabdomyosarcoma

Disease Ontology: 11 An orbit sarcoma that is that arises from primitive pleuripotential mesenchymal cells that possess the ability to differentiate into striated muscle, most often in young children.

MalaCards based summary: Orbit Rhabdomyosarcoma, also known as rhabdomyosarcoma of the orbit, is related to orbit embryonal rhabdomyosarcoma and neurofibromatosis, type i. An important gene associated with Orbit Rhabdomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are MAP Kinase Signaling and Neural crest differentiation. Affiliated tissues include bone, eye and breast, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Orbit Rhabdomyosarcoma

Diseases related to Orbit Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 orbit embryonal rhabdomyosarcoma 30.5 TFAP2B PAX7 PAX3 NF1 MYOG MB
2 neurofibromatosis, type i 29.6 NRAS NF1 EWSR1
3 leiomyosarcoma 29.6 NF1 MYOG MLANA MB HMGA2
4 pleomorphic rhabdomyosarcoma 29.5 PAX7 PAX3 NF1 MYOG MYOD1 FOXO1
5 sarcoma 29.5 MYOG MYOD1 MB FOXO1 EWSR1
6 mesenchymal cell neoplasm 29.1 NF1 MYOG MLANA HMGA2 EWSR1
7 embryonal rhabdomyosarcoma 28.9 PAX7 PAX3 NF1 MYOG MYOD1 MB
8 rhabdomyosarcoma 2 28.6 PAX7 PAX3 NF1 MYOG MYOD1 MB
9 melanoma 28.1 TYR PAX3 NRAS NF1 MLANA IFNA2
10 rhabdomyosarcoma 27.9 PAX7 PAX3 NRAS NF1 MYOG MYOD1
11 orbit alveolar rhabdomyosarcoma 11.2
12 malignant glandular tumor of peripheral nerve sheath 10.4 NF1 MYOG
13 central nervous system rhabdomyosarcoma 10.3 PAX3 FOXO1
14 medullomyoblastoma 10.3 MYOG MB
15 adult fibrosarcoma 10.3 PAX3 MYOG
16 gallbladder sarcoma 10.3 MYOG MYOD1
17 pineal region teratoma 10.3 MYOG MYOD1
18 parietal lobe neoplasm 10.2 MYOG MYOD1
19 mechanical ectropion 10.2 NF1 IFNA2
20 myoblastoma 10.2 MYOG MYOD1
21 prostate rhabdomyosarcoma 10.2 MYOG MYOD1
22 prostate sarcoma 10.2 MYOG MYOD1
23 vagina leiomyosarcoma 10.2 MYOG MLANA
24 basal cell nevus syndrome 10.2 PAX7 PAX3 NF1
25 prostate stromal sarcoma 10.2 MYOG MYOD1
26 hypomelanosis of ito 10.2 NF1 GNAQ
27 central epithelioid sarcoma 10.2 MB KRT20
28 cervical adenosarcoma 10.2 MYOG MYOD1
29 oral rhabdomyosarcoma 10.2 PAX3 MYOG MYOD1
30 vulvar proximal-type epithelioid sarcoma 10.2 MB KRT20
31 skeletal muscle neoplasm 10.2 MYOG MYOD1 MB
32 malignant mesenchymoma 10.2 MYOG MYOD1 MB
33 adult malignant schwannoma 10.2 NF1 MYOG
34 squamous papillomatosis 10.2 KRT20 IFNA2
35 small intestine leiomyoma 10.2 NF1 MLANA
36 rare tumor 10.2
37 malignant granular cell myoblastoma 10.2 MLANA MB
38 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.1 PAX7 MYOG MYOD1
39 epithelioid leiomyosarcoma 10.1 MYOG MLANA
40 thymus lipoma 10.1 MB HMGA2
41 immune system organ benign neoplasm 10.1 MB HMGA2
42 sarcomatoid squamous cell skin carcinoma 10.1 MYOG MLANA
43 chest wall lipoma 10.1 NF1 HMGA2
44 skin lipoma 10.1 NF1 HMGA2
45 malignant choroid melanoma 10.1 MLANA GNAQ
46 mediastinal lipomatosis 10.1 MB HMGA2
47 internal hemorrhoid 10.1 MLANA KRT20
48 conjunctival pigmentation 10.1 MLANA IFNA2
49 anal paget's disease 10.1 MLANA KRT20
50 ullrich congenital muscular dystrophy 1 10.1 PAX7 MYOG MYOD1

Graphical network of the top 20 diseases related to Orbit Rhabdomyosarcoma:



Diseases related to Orbit Rhabdomyosarcoma

Symptoms & Phenotypes for Orbit Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
2 no effect GR00402-S-2 10.18 EWSR1 FGFR4 FOXO1 GNAQ HLA-G HMGA2

MGI Mouse Phenotypes related to Orbit Rhabdomyosarcoma:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
2 growth/size/body region MP:0005378 10.4 EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
3 neoplasm MP:0002006 10.31 EWSR1 FANCD2 FGFR4 FOXO1 HMGA2 MYOD1
4 normal MP:0002873 10.3 EWSR1 FOXO1 GNAQ IFNA2 MYOD1 MYOG
5 cellular MP:0005384 10.25 EWSR1 FANCD2 FGFR4 FOXO1 HMGA2 MB
6 muscle MP:0005369 10.24 EWSR1 FOXO1 GNAQ MB MYOD1 MYOG
7 limbs/digits/tail MP:0005371 10.22 EWSR1 FANCD2 FOXO1 GNAQ HMGA2 NF1
8 endocrine/exocrine gland MP:0005379 10.22 EWSR1 FANCD2 FOXO1 GNAQ HLA-G HMGA2
9 behavior/neurological MP:0005386 10.21 EWSR1 FANCD2 FOXO1 GNAQ HLA-G HMGA2
10 no phenotypic analysis MP:0003012 10.2 FOXO1 HLA-G MLANA MYOD1 MYOG NRAS
11 craniofacial MP:0005382 10.11 FOXO1 GNAQ HMGA2 NF1 NRAS PAX3
12 cardiovascular system MP:0005385 10.1 FOXO1 GNAQ HLA-G MB MYOD1 NF1
13 immune system MP:0005387 10.1 EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
14 pigmentation MP:0001186 10.05 GNAQ MLANA NF1 NRAS PAX3 TYR
15 respiratory system MP:0005388 9.96 FGFR4 GNAQ IFNA2 MB MYOD1 MYOG
16 skeleton MP:0005390 9.9 EWSR1 FOXO1 GNAQ HMGA2 MYOD1 MYOG
17 mortality/aging MP:0010768 9.86 EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
18 integument MP:0010771 9.4 EWSR1 FOXO1 GNAQ HMGA2 MLANA MYOG

Drugs & Therapeutics for Orbit Rhabdomyosarcoma

Search Clinical Trials, NIH Clinical Center for Orbit Rhabdomyosarcoma

Cochrane evidence based reviews: rhabdomyosarcoma of the orbit

Genetic Tests for Orbit Rhabdomyosarcoma

Anatomical Context for Orbit Rhabdomyosarcoma

Organs/tissues related to Orbit Rhabdomyosarcoma:

MalaCards : Bone, Eye, Breast, Kidney, Liver

Publications for Orbit Rhabdomyosarcoma

Articles related to Orbit Rhabdomyosarcoma:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Spindle Cell/Sclerosing Rhabdomyosarcoma of the Orbit. 62
35829629 2022
2
Bacteremia due to Weeksella virosa in a pediatric patient with embryonal rhabdomyosarcoma. 62
32496471 2020
3
Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique. 62
29204167 2017
4
Rhabdomyosarcoma of the orbit in a four months old infant in Zimbabwe: A case report. 62
26255332 2012
5
Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. 62
21421211 2011
6
[Two cases of orbital embryonal rhabdomyosarcoma with chromosome aberration]. 62
20432963 2010
7
An unusual presentation of alveolar type of rhabdomyosarcoma of orbit. 62
21105560 2009
8
Pathology teach and tell: solid variant alveolar rhabdomyosarcoma of the orbit. 62
16754488 2006
9
Embryonal rhabdomyosarcoma of the orbit in a liver transplant recipient. 62
12819877 2003
10
Management of alveolar rhabdomyosarcoma of the orbit. 62
12485290 2002
11
Late malignant melanoma after treatment of rhabdomyosarcoma of the orbit during childhood. 62
12149065 2002
12
Microsatellite instability in three cases of embryonal rhabdomyosarcoma of the orbit. 62
12116063 2002
13
Letter to the editor: neurofibromatosis type 1 (NF 1) associated with embryonal rhabdomyosarcoma of the orbit. 62
11984810 2002
14
Embryonal rhabdomyosarcoma of the orbit in a 38-year-old woman. 62
11338467 2001
15
One-stage reconstruction of the eye socket with vascularized temporalis muscle flap in orbital exenteration. 62
11930832 2001
16
Late effects of therapy in 94 patients with localized rhabdomyosarcoma of the orbit: Report from the Intergroup Rhabdomyosarcoma Study (IRS)-III, 1984-1991. 62
10842248 2000
17
Rhabdomyosarcoma of the orbit. Evaluation with MR imaging and CT. 62
9884698 1998
18
[Rhabdomyosarcoma of the orbit]. 62
9213517 1997
19
[The initial clinical manifestations of rhabdomyosarcoma]. 62
7655215 1995
20
Findings of magnetic resonance and colour-flow Doppler imaging of orbital embryonal rhabdomyosarcoma. 62
8193970 1994
21
Embryonal rhabdomyosarcoma of the orbit in a 35-year-old man. 62
8058268 1994
22
[Embryonal rhabdomyosarcoma of the orbit]. 62
8186204 1994
23
Rhabdomyosarcoma of the orbit. 62
8507239 1993
24
Rhabdomyosarcoma of the orbit. 62
8407187 1993
25
[Leiomyosarcoma of the breast 16 years following successful treatment of a rhabdomyosarcoma of the orbit in childhood]. 62
1411391 1992
26
[Rhabdomyosarcoma of the orbit]. 62
1394530 1992
27
[Malignant tumors of the head and neck in children. Part I--review]. 62
1448293 1992
28
Acute megakaryocytic leukemia in children. Clinical, immunologic, and cytogenetic findings in two patients. 62
1833041 1991
29
The role of chemotherapy, surgery, and radiotherapy in rhabdomyosarcoma of the orbit. 62
1845177 1991
30
Embryonal rhabdomyosarcoma of orbit--a case report. 62
2086480 1990
31
Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. 62
2119961 1990
32
[Rhabdomyosarcoma in children]. 62
2281635 1990
33
[Immunocytochemical diagnosis of embryonal rhabdomyosarcoma of the orbit]. 62
2681959 1989
34
Rhabdomyosarcoma of the orbit. 62
4034789 1985
35
[Clinico-pathological study of rhabdomyosarcoma of the orbit: report of 12 cases]. 62
3930174 1985
36
[Ocular and orbital sequellae in the treatment of embryonic rhabdomyosarcoma of the orbit. Apropos of 3 cases]. 62
6524837 1984
37
Rhabdomyosarcoma and late malignant melanoma of the orbit. 62
6657203 1983
38
Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 62
6654047 1983
39
[An embryonal rhabdomyosarcoma of the orbit in a young adult]. 62
7184550 1982
40
[Treatment of orbital rhabdomyosarcoma (author's transl)]. 62
7099686 1982
41
Medical therapy of orbit rhabdomyosarcoma in children. 62
7143084 1982
42
[Embryonal rhabdomyosarcoma of the orbit -- a totally extirpated case with long-term survival (author's transl)]. 62
6163098 1980
43
Orbital embryonal rhabdomyosarcoma and intracranial schwannoma. 62
314794 1979
44
[Actual treatment of rhabdomyosarcoma of the orbit in children (author's transl)]. 62
151705 1978
45
[Rhabdomyosarcoma of the orbit in childhood. Observation of 8 cases]. 62
642880 1978
46
[Embryonal rhabdomyosarcoma of the orbit. Apropos of 24 cases]. 62
140644 1976
47
Rhabdomyosarcoma of the orbit in the newborn. 62
1200095 1975
48
Electron microscopic and electron histochemical studies on embryonal rhabdomyosarcoma of the orbit. 62
169642 1975
49
Rhabdomyosarcoma of the orbit. 62
4418944 1974
50
[Rhabdomyosarcoma of the orbit. Attempt at radioactive cobalt treatment]. 62
4828400 1974

Variations for Orbit Rhabdomyosarcoma

Expression for Orbit Rhabdomyosarcoma

Search GEO for disease gene expression data for Orbit Rhabdomyosarcoma.

Pathways for Orbit Rhabdomyosarcoma

Pathways related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 NRAS NF1 GNAQ
2 11.34 TFAP2B PAX7 PAX3
3 10.9 PAX7 PAX3 MYOG MYOD1
4 10.58 TYR MLANA GNAQ

GO Terms for Orbit Rhabdomyosarcoma

Cellular components related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.5 TFAP2B PAX7 PAX3 MYOG MYOD1 HMGA2

Biological processes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of DNA-templated transcription GO:0006355 9.85 EWSR1 FOXO1 HMGA2 MYOD1 MYOG PAX3
2 skeletal muscle tissue development GO:0007519 9.8 NF1 MYOG MYOD1
3 positive regulation of skeletal muscle fiber development GO:0048743 9.67 MYOG MYOD1
4 muscle cell fate commitment GO:0042693 9.56 MYOG MYOD1
5 muscle organ development GO:0007517 9.5 PAX7 PAX3 MYOG MYOD1
6 myotube differentiation GO:0014902 9.4 MYOG MYOD1
7 anatomical structure development GO:0048856 9.23 TFAP2B PAX7 PAX3 MYOG MYOD1

Molecular functions related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.81 TFAP2B PAX3 MYOG MYOD1 FOXO1
2 DNA-binding transcription factor activity GO:0003700 9.36 TFAP2B PAX7 PAX3 MYOG MYOD1 FOXO1
3 cis-regulatory region sequence-specific DNA binding GO:0000987 9.26 TFAP2B MYOG MYOD1

Sources for Orbit Rhabdomyosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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