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MCID: ORB011
MIFTS: 34

Orbit Rhabdomyosarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Orbit Rhabdomyosarcoma

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MalaCards integrated aliases for Orbit Rhabdomyosarcoma:

Name: Orbit Rhabdomyosarcoma 12 15
Rhabdomyosarcoma of the Orbit 12 44 70
Rhabdomyosarcoma of Orbit 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3259
MeSH 44 C537605
NCIt 50 C4543
SNOMED-CT 67 254994000
UMLS 70 C0346347
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Summaries for Orbit Rhabdomyosarcoma

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Disease Ontology : 12 An orbit sarcoma that is that arises from primitive pleuripotential mesenchymal cells that possess the ability to differentiate into striated muscle, most often in young children.

MalaCards based summary : Orbit Rhabdomyosarcoma, also known as rhabdomyosarcoma of the orbit, is related to orbit embryonal rhabdomyosarcoma and pleomorphic rhabdomyosarcoma. An important gene associated with Orbit Rhabdomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Neuroscience and Pathways in cancer. Affiliated tissues include skin, breast and thymus, and related phenotypes are homeostasis/metabolism and cellular

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Related Diseases for Orbit Rhabdomyosarcoma

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Diseases related to Orbit Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 orbit embryonal rhabdomyosarcoma 30.6 TFAP2B PAX7 PAX3 NF1 MYOG MB
2 pleomorphic rhabdomyosarcoma 30.1 PAX7 PAX3 MYOG MB FOXO1
3 leiomyosarcoma 29.7 NF1 MYOG MLANA MB HMGA2
4 embryonal rhabdomyosarcoma 29.3 PAX7 PAX3 MYOG MYCN MB FOXO1
5 rhabdomyosarcoma 2 29.1 PAX7 PAX3 MYOG MYCN MB FOXO1
6 rhabdomyosarcoma 27.8 PAX7 PAX3 NRAS NF1 MYOG MYCN
7 orbit alveolar rhabdomyosarcoma 11.1
8 skeletal muscle neoplasm 10.4 MYOG MB
9 central nervous system rhabdomyosarcoma 10.4 PAX3 FOXO1
10 conventional leiomyosarcoma 10.4 PAX7 MYOG
11 medullomyoblastoma 10.4 MYOG MB
12 inflammatory leiomyosarcoma 10.4 PAX7 MYOG
13 adult malignant schwannoma 10.4 NF1 MYOG
14 dacryocystocele 10.3 PAX3 NF1
15 malignant mesenchymoma 10.3 MYOG MB
16 chronic inflammation of lacrimal passage 10.3 PAX3 NF1
17 thymus lipoma 10.3 MB KRT20
18 immune system organ benign neoplasm 10.3 MB KRT20
19 botryoid rhabdomyosarcoma 10.3 PAX3 MYOG MB
20 mechanical ectropion 10.3 NF1 IFNA2
21 spindle cell rhabdomyosarcoma 10.3 PAX3 MYOG MB
22 conventional fibrosarcoma 10.3 PAX7 PAX3 MB
23 lung leiomyosarcoma 10.3 MYOG KRT20
24 breast osteosarcoma 10.2 MYOG KRT20
25 vagina leiomyosarcoma 10.2 MYOG MLANA
26 ocular albinism with congenital sensorineural deafness 10.2 TYR PAX3
27 small intestine leiomyoma 10.2 NF1 MLANA
28 malignant granular cell myoblastoma 10.2 MLANA MB
29 schwannoma of twelfth cranial nerve 10.2 NF1 MLANA
30 squamous papillomatosis 10.2 KRT20 IFNA2
31 hypoglossal nerve disease 10.2 NF1 MLANA
32 retroperitoneal sarcoma 10.2 MYOG MLANA
33 glomangiomatosis 10.2 MLANA MB
34 vagina sarcoma 10.2 MYOG MLANA
35 central epithelioid sarcoma 10.2 MB KRT20
36 albinism, ocular, with late-onset sensorineural deafness 10.2 TYR PAX3
37 rare tumor 10.1
38 meningeal melanocytoma 10.1 MLANA GNAQ
39 muscle tissue disease 10.1 PAX7 MYOG MB
40 vulvar proximal-type epithelioid sarcoma 10.1 MB KRT20
41 conjunctival pigmentation 10.1 MLANA IFNA2
42 horner's syndrome 10.1 NF1 MYCN
43 uterus leiomyosarcoma 10.1 MYOG MLANA
44 kidney rhabdoid cancer 10.1 MB EWSR1
45 epithelioid malignant peripheral nerve sheath tumor 10.1 NF1 MYOG MLANA
46 bilateral retinoblastoma 10.1 MYOG MYCN MB
47 clear cell basal cell carcinoma 10.1 PAX7 PAX3 MYOG KRT20
48 extraosseous ewing sarcoma 10.1 MYOG EWSR1
49 cerebellum cancer 10.1 NF1 MYCN
50 ciliary body cancer 10.1 TYR MLANA

Graphical network of the top 20 diseases related to Orbit Rhabdomyosarcoma:



Diseases related to Orbit Rhabdomyosarcoma
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Symptoms & Phenotypes for Orbit Rhabdomyosarcoma

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MGI Mouse Phenotypes related to Orbit Rhabdomyosarcoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 FANCD2 FGFR4 FOXO1 GNAQ HLA-G MB
2 cellular MP:0005384 10.34 FANCD2 FGFR4 FOXO1 MB MYCN MYOG
3 growth/size/body region MP:0005378 10.34 FANCD2 FGFR4 FOXO1 GNAQ MB MYCN
4 cardiovascular system MP:0005385 10.27 FOXO1 GNAQ MB MYCN NF1 NRAS
5 mortality/aging MP:0010768 10.27 FANCD2 FGFR4 FOXO1 GNAQ MB MYCN
6 craniofacial MP:0005382 10.2 FOXO1 GNAQ MYCN NF1 NRAS PAX3
7 embryo MP:0005380 10.19 FOXO1 MB MYCN MYOG NF1 NRAS
8 integument MP:0010771 10.19 FOXO1 GNAQ MLANA MYOG NF1 NRAS
9 limbs/digits/tail MP:0005371 10.13 FANCD2 FOXO1 GNAQ MYCN NF1 NRAS
10 muscle MP:0005369 10.09 FOXO1 GNAQ MB MYCN MYOG NF1
11 neoplasm MP:0002006 10.01 FANCD2 FGFR4 FOXO1 NF1 NRAS PAX3
12 no phenotypic analysis MP:0003012 9.97 FOXO1 MLANA MYCN MYOG NRAS PAX3
13 normal MP:0002873 9.97 FOXO1 GNAQ MYCN MYOG NF1 NRAS
14 respiratory system MP:0005388 9.81 FGFR4 GNAQ MB MYCN MYOG NF1
15 pigmentation MP:0001186 9.73 GNAQ MLANA NF1 NRAS PAX3 TYR
16 skeleton MP:0005390 9.65 FGFR4 FOXO1 GNAQ MYCN MYOG NF1
17 vision/eye MP:0005391 9.28 FANCD2 FGFR4 MYCN NF1 NRAS PAX3
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Drugs & Therapeutics for Orbit Rhabdomyosarcoma

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Search Clinical Trials , NIH Clinical Center for Orbit Rhabdomyosarcoma

Cochrane evidence based reviews: rhabdomyosarcoma of the orbit

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Genetic Tests for Orbit Rhabdomyosarcoma

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Anatomical Context for Orbit Rhabdomyosarcoma

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MalaCards organs/tissues related to Orbit Rhabdomyosarcoma:

40
Skin, Breast, Thymus, Skeletal Muscle, Eye, Cerebellum, Spinal Cord
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Publications for Orbit Rhabdomyosarcoma

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Articles related to Orbit Rhabdomyosarcoma:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Bacteremia due to Weeksella virosa in a pediatric patient with embryonal rhabdomyosarcoma. 61
32496471 2020
2
Rhabdomyosarcoma of the orbit in a four months old infant in Zimbabwe: A case report. 61
26255332 2012
3
Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. 61
21421211 2011
4
[Two cases of orbital embryonal rhabdomyosarcoma with chromosome aberration]. 61
20432963 2010
5
Pathology teach and tell: solid variant alveolar rhabdomyosarcoma of the orbit. 61
16754488 2006
6
Embryonal rhabdomyosarcoma of the orbit in a liver transplant recipient. 61
12819877 2003
7
Management of alveolar rhabdomyosarcoma of the orbit. 61
12485290 2002
8
Late malignant melanoma after treatment of rhabdomyosarcoma of the orbit during childhood. 61
12149065 2002
9
Microsatellite instability in three cases of embryonal rhabdomyosarcoma of the orbit. 61
12116063 2002
10
Letter to the editor: neurofibromatosis type 1 (NF 1) associated with embryonal rhabdomyosarcoma of the orbit. 61
11984810 2002
11
Embryonal rhabdomyosarcoma of the orbit in a 38-year-old woman. 61
11338467 2001
12
One-stage reconstruction of the eye socket with vascularized temporalis muscle flap in orbital exenteration. 61
11930832 2001
13
Late effects of therapy in 94 patients with localized rhabdomyosarcoma of the orbit: Report from the Intergroup Rhabdomyosarcoma Study (IRS)-III, 1984-1991. 61
10842248 2000
14
Rhabdomyosarcoma of the orbit. Evaluation with MR imaging and CT. 61
9884698 1998
15
[Rhabdomyosarcoma of the orbit]. 61
9213517 1997
16
[The initial clinical manifestations of rhabdomyosarcoma]. 61
7655215 1995
17
Findings of magnetic resonance and colour-flow Doppler imaging of orbital embryonal rhabdomyosarcoma. 61
8193970 1994
18
Embryonal rhabdomyosarcoma of the orbit in a 35-year-old man. 61
8058268 1994
19
[Embryonal rhabdomyosarcoma of the orbit]. 61
8186204 1994
20
Rhabdomyosarcoma of the orbit. 61
8507239 1993
21
Rhabdomyosarcoma of the orbit. 61
8407187 1993
22
[Leiomyosarcoma of the breast 16 years following successful treatment of a rhabdomyosarcoma of the orbit in childhood]. 61
1411391 1992
23
[Rhabdomyosarcoma of the orbit]. 61
1394530 1992
24
[Malignant tumors of the head and neck in children. Part I--review]. 61
1448293 1992
25
Acute megakaryocytic leukemia in children. Clinical, immunologic, and cytogenetic findings in two patients. 61
1833041 1991
26
The role of chemotherapy, surgery, and radiotherapy in rhabdomyosarcoma of the orbit. 61
1845177 1991
27
Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. 61
2119961 1990
28
[Rhabdomyosarcoma in children]. 61
2281635 1990
29
[Immunocytochemical diagnosis of embryonal rhabdomyosarcoma of the orbit]. 61
2681959 1989
30
Rhabdomyosarcoma of the orbit. 61
4034789 1985
31
[Clinico-pathological study of rhabdomyosarcoma of the orbit: report of 12 cases]. 61
3930174 1985
32
[Ocular and orbital sequellae in the treatment of embryonic rhabdomyosarcoma of the orbit. Apropos of 3 cases]. 61
6524837 1984
33
Rhabdomyosarcoma and late malignant melanoma of the orbit. 61
6657203 1983
34
Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 61
6654047 1983
35
[An embryonal rhabdomyosarcoma of the orbit in a young adult]. 61
7184550 1982
36
[Treatment of orbital rhabdomyosarcoma (author's transl)]. 61
7099686 1982
37
Medical therapy of orbit rhabdomyosarcoma in children. 61
7143084 1982
38
[Embryonal rhabdomyosarcoma of the orbit -- a totally extirpated case with long-term survival (author's transl)]. 61
6163098 1980
39
Orbital embryonal rhabdomyosarcoma and intracranial schwannoma. 61
314794 1979
40
[Actual treatment of rhabdomyosarcoma of the orbit in children (author's transl)]. 61
151705 1978
41
[Rhabdomyosarcoma of the orbit in childhood. Observation of 8 cases]. 61
642880 1978
42
[Embryonal rhabdomyosarcoma of the orbit. Apropos of 24 cases]. 61
140644 1976
43
Rhabdomyosarcoma of the orbit in the newborn. 61
1200095 1975
44
Electron microscopic and electron histochemical studies on embryonal rhabdomyosarcoma of the orbit. 61
169642 1975
45
Rhabdomyosarcoma of the orbit. 61
4418944 1974
46
[Rhabdomyosarcoma of the orbit. Attempt at radioactive cobalt treatment]. 61
4828400 1974
47
Rhabdomyosarcoma of the orbit. 61
18730883 1973
48
Rhabdomyosarcoma of the orbit. 61
5163771 1971
49
[A case of embryonal rhabdomyosarcoma of the orbit]. 61
5317157 1971
50
Rhabdomyosarcoma of the orbit in a survivor of rhabdomyosarcoma of the kidney. 61
5777763 1969
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Variations for Orbit Rhabdomyosarcoma

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Expression for Orbit Rhabdomyosarcoma

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Search GEO for disease gene expression data for Orbit Rhabdomyosarcoma.
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Pathways for Orbit Rhabdomyosarcoma

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Pathways related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.24 TFAP2B NF1 MYCN GNAQ
2
Pathways in cancer 36
12.08 NRAS IFNA2 GNAQ FOXO1 FGFR4
3
MAP Kinase Signaling 4
11.6 NRAS NF1 GNAQ
4
Glioblastoma Multiforme 63
11.54 NRAS NF1 FOXO1
5
Neural Crest Differentiation 1
11.44 TFAP2B PAX7 PAX3
6
Transcriptional misregulation in cancer 36
11.38 PAX7 PAX3 MYCN HMGA2 FOXO1 EWSR1
7
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.31 PAX7 PAX3 MYOG
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GO Terms for Orbit Rhabdomyosarcoma

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Cellular components related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.17 TFAP2B PAX7 PAX3 MYOG MYCN HMGA2

Biological processes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.58 PAX7 PAX3 MYOG
2 regulation of transcription, DNA-templated GO:0006355 9.56 TFAP2B PAX7 PAX3 MYOG MYCN HMGA2
3 fat cell differentiation GO:0045444 9.5 TFAP2B HMGA2 FOXO1
4 sympathetic nervous system development GO:0048485 9.37 TFAP2B NF1
5 anatomical structure development GO:0048856 9.33 TFAP2B PAX7 PAX3
6 phosphate ion homeostasis GO:0055062 9.26 TFAP2B FGFR4
7 positive regulation of transcription, DNA-templated GO:0045893 9.17 TFAP2B PAX3 MYOG MYCN IFNA2 HMGA2

Molecular functions related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 TYR TFAP2B PAX7 PAX3 NRAS NF1
2 sequence-specific double-stranded DNA binding GO:1990837 9.35 TFAP2B PAX7 PAX3 MYOG MYCN
3 DNA-binding transcription factor activity GO:0003700 9.1 TFAP2B PAX7 PAX3 MYOG MYCN FOXO1
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Sources for Orbit Rhabdomyosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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