Orbit Rhabdomyosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Orbit Rhabdomyosarcoma

MalaCards integrated aliases for Orbit Rhabdomyosarcoma:

Name: Orbit Rhabdomyosarcoma ¹¹ ¹⁴

Rhabdomyosarcoma of the Orbit ¹¹ ⁴³ ⁷¹

Rhabdomyosarcoma of Orbit ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3259

MeSH ⁴³ C537605

NCIt ⁴⁹ C4543

SNOMED-CT ⁶⁸ 254994000

UMLS ⁷¹ C0346347

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Summaries for Orbit Rhabdomyosarcoma

Disease Ontology: ¹¹ An orbit sarcoma that is that arises from primitive pleuripotential mesenchymal cells that possess the ability to differentiate into striated muscle, most often in young children.

MalaCards based summary: Orbit Rhabdomyosarcoma, also known as rhabdomyosarcoma of the orbit, is related to orbit embryonal rhabdomyosarcoma and neurofibromatosis, type i. An important gene associated with Orbit Rhabdomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are MAP Kinase Signaling and Neural crest differentiation. Affiliated tissues include bone, eye and breast, and related phenotypes are homeostasis/metabolism and growth/size/body region

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Related Diseases for Orbit Rhabdomyosarcoma

Diseases related to Orbit Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)

#	Related Disease	Score	Top Affiliating Genes
1	orbit embryonal rhabdomyosarcoma	30.5	TFAP2B PAX7 PAX3 NF1 MYOG MB
2	neurofibromatosis, type i	29.6	NRAS NF1 EWSR1
3	leiomyosarcoma	29.6	NF1 MYOG MLANA MB HMGA2
4	pleomorphic rhabdomyosarcoma	29.5	PAX7 PAX3 NF1 MYOG MYOD1 FOXO1
5	sarcoma	29.5	MYOG MYOD1 MB FOXO1 EWSR1
6	mesenchymal cell neoplasm	29.1	NF1 MYOG MLANA HMGA2 EWSR1
7	embryonal rhabdomyosarcoma	28.9	PAX7 PAX3 NF1 MYOG MYOD1 MB
8	rhabdomyosarcoma 2	28.6	PAX7 PAX3 NF1 MYOG MYOD1 MB
9	melanoma	28.1	TYR PAX3 NRAS NF1 MLANA IFNA2
10	rhabdomyosarcoma	27.9	PAX7 PAX3 NRAS NF1 MYOG MYOD1
11	orbit alveolar rhabdomyosarcoma	11.2
12	malignant glandular tumor of peripheral nerve sheath	10.4	NF1 MYOG
13	central nervous system rhabdomyosarcoma	10.3	PAX3 FOXO1
14	medullomyoblastoma	10.3	MYOG MB
15	adult fibrosarcoma	10.3	PAX3 MYOG
16	gallbladder sarcoma	10.3	MYOG MYOD1
17	pineal region teratoma	10.3	MYOG MYOD1
18	parietal lobe neoplasm	10.2	MYOG MYOD1
19	mechanical ectropion	10.2	NF1 IFNA2
20	myoblastoma	10.2	MYOG MYOD1
21	prostate rhabdomyosarcoma	10.2	MYOG MYOD1
22	prostate sarcoma	10.2	MYOG MYOD1
23	vagina leiomyosarcoma	10.2	MYOG MLANA
24	basal cell nevus syndrome	10.2	PAX7 PAX3 NF1
25	prostate stromal sarcoma	10.2	MYOG MYOD1
26	hypomelanosis of ito	10.2	NF1 GNAQ
27	central epithelioid sarcoma	10.2	MB KRT20
28	cervical adenosarcoma	10.2	MYOG MYOD1
29	oral rhabdomyosarcoma	10.2	PAX3 MYOG MYOD1
30	vulvar proximal-type epithelioid sarcoma	10.2	MB KRT20
31	skeletal muscle neoplasm	10.2	MYOG MYOD1 MB
32	malignant mesenchymoma	10.2	MYOG MYOD1 MB
33	adult malignant schwannoma	10.2	NF1 MYOG
34	squamous papillomatosis	10.2	KRT20 IFNA2
35	small intestine leiomyoma	10.2	NF1 MLANA
36	rare tumor	10.2
37	malignant granular cell myoblastoma	10.2	MLANA MB
38	emery-dreifuss muscular dystrophy 2, autosomal dominant	10.1	PAX7 MYOG MYOD1
39	epithelioid leiomyosarcoma	10.1	MYOG MLANA
40	thymus lipoma	10.1	MB HMGA2
41	immune system organ benign neoplasm	10.1	MB HMGA2
42	sarcomatoid squamous cell skin carcinoma	10.1	MYOG MLANA
43	chest wall lipoma	10.1	NF1 HMGA2
44	skin lipoma	10.1	NF1 HMGA2
45	malignant choroid melanoma	10.1	MLANA GNAQ
46	mediastinal lipomatosis	10.1	MB HMGA2
47	internal hemorrhoid	10.1	MLANA KRT20
48	conjunctival pigmentation	10.1	MLANA IFNA2
49	anal paget's disease	10.1	MLANA KRT20
50	ullrich congenital muscular dystrophy 1	10.1	PAX7 MYOG MYOD1

Graphical network of the top 20 diseases related to Orbit Rhabdomyosarcoma:

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Symptoms & Phenotypes for Orbit Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
2	no effect	GR00402-S-2	10.18	EWSR1 FGFR4 FOXO1 GNAQ HLA-G HMGA2

MGI Mouse Phenotypes related to Orbit Rhabdomyosarcoma:

⁴⁵ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
2	growth/size/body region	MP:0005378	10.4	EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
3	neoplasm	MP:0002006	10.31	EWSR1 FANCD2 FGFR4 FOXO1 HMGA2 MYOD1
4	normal	MP:0002873	10.3	EWSR1 FOXO1 GNAQ IFNA2 MYOD1 MYOG
5	cellular	MP:0005384	10.25	EWSR1 FANCD2 FGFR4 FOXO1 HMGA2 MB
6	muscle	MP:0005369	10.24	EWSR1 FOXO1 GNAQ MB MYOD1 MYOG
7	limbs/digits/tail	MP:0005371	10.22	EWSR1 FANCD2 FOXO1 GNAQ HMGA2 NF1
8	endocrine/exocrine gland	MP:0005379	10.22	EWSR1 FANCD2 FOXO1 GNAQ HLA-G HMGA2
9	behavior/neurological	MP:0005386	10.21	EWSR1 FANCD2 FOXO1 GNAQ HLA-G HMGA2
10	no phenotypic analysis	MP:0003012	10.2	FOXO1 HLA-G MLANA MYOD1 MYOG NRAS
11	craniofacial	MP:0005382	10.11	FOXO1 GNAQ HMGA2 NF1 NRAS PAX3
12	cardiovascular system	MP:0005385	10.1	FOXO1 GNAQ HLA-G MB MYOD1 NF1
13	immune system	MP:0005387	10.1	EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
14	pigmentation	MP:0001186	10.05	GNAQ MLANA NF1 NRAS PAX3 TYR
15	respiratory system	MP:0005388	9.96	FGFR4 GNAQ IFNA2 MB MYOD1 MYOG
16	skeleton	MP:0005390	9.9	EWSR1 FOXO1 GNAQ HMGA2 MYOD1 MYOG
17	mortality/aging	MP:0010768	9.86	EWSR1 FANCD2 FGFR4 FOXO1 GNAQ HLA-G
18	integument	MP:0010771	9.4	EWSR1 FOXO1 GNAQ HMGA2 MLANA MYOG

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Drugs & Therapeutics for Orbit Rhabdomyosarcoma

Search Clinical Trials, NIH Clinical Center for Orbit Rhabdomyosarcoma

Cochrane evidence based reviews: rhabdomyosarcoma of the orbit

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Genetic Tests for Orbit Rhabdomyosarcoma

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Anatomical Context for Orbit Rhabdomyosarcoma

Organs/tissues related to Orbit Rhabdomyosarcoma:

MalaCards : Bone, Eye, Breast, Kidney, Liver

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Publications for Orbit Rhabdomyosarcoma

Articles related to Orbit Rhabdomyosarcoma:

(show top 50) (show all 72)

#	Title	Authors	PMID	Year
1	Spindle Cell/Sclerosing Rhabdomyosarcoma of the Orbit. ⁶²	Proia AD	35829629	2022
2	Bacteremia due to Weeksella virosa in a pediatric patient with embryonal rhabdomyosarcoma. ⁶²	Vaquera-Aparicio DN...Castillo-Bejarano JI	32496471	2020
3	Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique. ⁶²	Laskar S...Ghadi Y	29204167	2017
4	Rhabdomyosarcoma of the orbit in a four months old infant in Zimbabwe: A case report. ⁶²	Chitsike I...Kuona P	26255332	2012
5	Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. ⁶²	Chen SC...Sheu SJ	21421211	2011
6	[Two cases of orbital embryonal rhabdomyosarcoma with chromosome aberration]. ⁶²	Tsuchisaka A...Suzuki S	20432963	2010
7	An unusual presentation of alveolar type of rhabdomyosarcoma of orbit. ⁶²	Bastola P...Adhikari RK	21105560	2009
8	Pathology teach and tell: solid variant alveolar rhabdomyosarcoma of the orbit. ⁶²	Passmore LM...Gilbert-Barness E	16754488	2006
9	Embryonal rhabdomyosarcoma of the orbit in a liver transplant recipient. ⁶²	Cescon M...Cavallari A	12819877	2003
10	Management of alveolar rhabdomyosarcoma of the orbit. ⁶²	Seregard S	12485290	2002
11	Late malignant melanoma after treatment of rhabdomyosarcoma of the orbit during childhood. ⁶²	Lumbroso L...Desjardins L	12149065	2002
12	Microsatellite instability in three cases of embryonal rhabdomyosarcoma of the orbit. ⁶²	Mastrangelo D...Lore' C	12116063	2002
13	Letter to the editor: neurofibromatosis type 1 (NF 1) associated with embryonal rhabdomyosarcoma of the orbit. ⁶²	Hadjistilianou T...Galluzzi P	11984810	2002
14	Embryonal rhabdomyosarcoma of the orbit in a 38-year-old woman. ⁶²	Mulugeta A...Bezabih K	11338467	2001
15	One-stage reconstruction of the eye socket with vascularized temporalis muscle flap in orbital exenteration. ⁶²	Shipkov HD...Anastassov YK	11930832	2001
16	Late effects of therapy in 94 patients with localized rhabdomyosarcoma of the orbit: Report from the Intergroup Rhabdomyosarcoma Study (IRS)-III, 1984-1991. ⁶²	Raney RB...Maurer HM	10842248	2000
17	Rhabdomyosarcoma of the orbit. Evaluation with MR imaging and CT. ⁶²	Mafee MF...Philip B	9884698	1998
18	[Rhabdomyosarcoma of the orbit]. ⁶²	Gerinec A...Galbavy S	9213517	1997
19	[The initial clinical manifestations of rhabdomyosarcoma]. ⁶²	Schworm HD...Stefani FH	7655215	1995
20	Findings of magnetic resonance and colour-flow Doppler imaging of orbital embryonal rhabdomyosarcoma. ⁶²	Cooper S...Lin DT	8193970	1994
21	Embryonal rhabdomyosarcoma of the orbit in a 35-year-old man. ⁶²	Mamalis N...Anderson RL	8058268	1994
22	[Embryonal rhabdomyosarcoma of the orbit]. ⁶²	Cernea P...Glavici A	8186204	1994
23	Rhabdomyosarcoma of the orbit. ⁶²	Schlienger P	8507239	1993
24	Rhabdomyosarcoma of the orbit. ⁶²	Shields JA...Shields CL	8407187	1993
25	[Leiomyosarcoma of the breast 16 years following successful treatment of a rhabdomyosarcoma of the orbit in childhood]. ⁶²	Buser K...Brunner KW	1411391	1992
26	[Rhabdomyosarcoma of the orbit]. ⁶²	Pliskvova I...Omelkova A	1394530	1992
27	[Malignant tumors of the head and neck in children. Part I--review]. ⁶²	Mueller-Malesinska M	1448293	1992
28	Acute megakaryocytic leukemia in children. Clinical, immunologic, and cytogenetic findings in two patients. ⁶²	Slavc I...Koller U	1833041	1991
29	The role of chemotherapy, surgery, and radiotherapy in rhabdomyosarcoma of the orbit. ⁶²	van Manen SR...Voute PA	1845177	1991
30	Embryonal rhabdomyosarcoma of orbit--a case report. ⁶²	Maurya OP...Kumar M	2086480	1990
31	Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. ⁶²	Sun XL...Kanda M	2119961	1990
32	[Rhabdomyosarcoma in children]. ⁶²	Bukhny AF...Tseitlin GIa	2281635	1990
33	[Immunocytochemical diagnosis of embryonal rhabdomyosarcoma of the orbit]. ⁶²	Holbach L...Meythaler FH	2681959	1989
34	Rhabdomyosarcoma of the orbit. ⁶²	Buckman G	4034789	1985
35	[Clinico-pathological study of rhabdomyosarcoma of the orbit: report of 12 cases]. ⁶²	Cai RH	3930174	1985
36	[Ocular and orbital sequellae in the treatment of embryonic rhabdomyosarcoma of the orbit. Apropos of 3 cases]. ⁶²	Behar C...Talmud M	6524837	1984
37	Rhabdomyosarcoma and late malignant melanoma of the orbit. ⁶²	Leff SR...Henkind P	6657203	1983
38	Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. ⁶²	Dempster AG...Downie T	6654047	1983
39	[An embryonal rhabdomyosarcoma of the orbit in a young adult]. ⁶²	Hamard H...Richard J	7184550	1982
40	[Treatment of orbital rhabdomyosarcoma (author's transl)]. ⁶²	Jurgensen OA...Pichler E	7099686	1982
41	Medical therapy of orbit rhabdomyosarcoma in children. ⁶²	Acquaviva A...Lasorella G	7143084	1982
42	[Embryonal rhabdomyosarcoma of the orbit -- a totally extirpated case with long-term survival (author's transl)]. ⁶²	Yamazaki H...Kawafuchi J	6163098	1980
43	Orbital embryonal rhabdomyosarcoma and intracranial schwannoma. ⁶²	Trese MT...Brown WJ	314794	1979
44	[Actual treatment of rhabdomyosarcoma of the orbit in children (author's transl)]. ⁶²	Flamant F...Campinchi R	151705	1978
45	[Rhabdomyosarcoma of the orbit in childhood. Observation of 8 cases]. ⁶²	De Bernardi B...Vinante O	642880	1978
46	[Embryonal rhabdomyosarcoma of the orbit. Apropos of 24 cases]. ⁶²	Offret G...Cardozo S	140644	1976
47	Rhabdomyosarcoma of the orbit in the newborn. ⁶²	Ellenbogen E...Lasky MA	1200095	1975
48	Electron microscopic and electron histochemical studies on embryonal rhabdomyosarcoma of the orbit. ⁶²	Amemiya T...Uchida S	169642	1975
49	Rhabdomyosarcoma of the orbit. ⁶²	Aviles E	4418944	1974
50	[Rhabdomyosarcoma of the orbit. Attempt at radioactive cobalt treatment]. ⁶²	Maciejewski Z	4828400	1974

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Genes for Orbit Rhabdomyosarcoma

Genes related to Orbit Rhabdomyosarcoma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYOG	Myogenin	Protein Coding	5.01	DISEASES inferred ¹⁴
2	PAX3	Paired Box 3	Protein Coding	4.75	DISEASES inferred ¹⁴
3	MB	Myoglobin	Protein Coding	4.71	DISEASES inferred ¹⁴
4	NF1	Neurofibromin 1	Protein Coding	4.58	DISEASES inferred ¹⁴
5	TFAP2B	Transcription Factor AP-2 Beta	Protein Coding	4.42	DISEASES inferred ¹⁴
6	FOXO1	Forkhead Box O1	Protein Coding	4	DISEASES inferred ¹⁴
7	PAX7	Paired Box 7	Protein Coding	3.54	DISEASES inferred ¹⁴
8	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	3.48	DISEASES inferred ¹⁴
9	FANCD2	FA Complementation Group D2	Protein Coding	3.44	DISEASES inferred ¹⁴
10	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	3.4	DISEASES inferred ¹⁴
11	KRT20	Keratin 20	Protein Coding	3.35	DISEASES inferred ¹⁴
12	GNAQ	G Protein Subunit Alpha Q	Protein Coding	3.24	DISEASES inferred ¹⁴
13	IFNA2	Interferon Alpha 2	Protein Coding	3.2	DISEASES inferred ¹⁴
14	MYOD1	Myogenic Differentiation 1	Protein Coding	3.16	DISEASES inferred ¹⁴
15	TYR	Tyrosinase	Protein Coding	3.14	DISEASES inferred ¹⁴
16	MLANA	Melan-A	Protein Coding	3.13	DISEASES inferred ¹⁴
17	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	3.11	DISEASES inferred ¹⁴
18	EWSR1	EWS RNA Binding Protein 1	Protein Coding	3.1	DISEASES inferred ¹⁴
19	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2.86	DISEASES inferred ¹⁴

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Variations for Orbit Rhabdomyosarcoma

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Expression for Orbit Rhabdomyosarcoma

Search GEO for disease gene expression data for Orbit Rhabdomyosarcoma.

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Pathways for Orbit Rhabdomyosarcoma

Pathways related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MAP Kinase Signaling ³	11.49	NRAS NF1 GNAQ
2	Neural crest differentiation ⁷⁴	11.34	TFAP2B PAX7 PAX3
3	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	10.9	PAX7 PAX3 MYOG MYOD1
4	GPR143 in melanocytes and retinal pigment epithelium cells ⁷⁴	10.58	TYR MLANA GNAQ

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GO Terms for Orbit Rhabdomyosarcoma

Cellular components related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin	GO:0000785	9.5	TFAP2B PAX7 PAX3 MYOG MYOD1 HMGA2

Biological processes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of DNA-templated transcription	GO:0006355	9.85	EWSR1 FOXO1 HMGA2 MYOD1 MYOG PAX3
2	skeletal muscle tissue development	GO:0007519	9.8	NF1 MYOG MYOD1
3	positive regulation of skeletal muscle fiber development	GO:0048743	9.67	MYOG MYOD1
4	muscle cell fate commitment	GO:0042693	9.56	MYOG MYOD1
5	muscle organ development	GO:0007517	9.5	PAX7 PAX3 MYOG MYOD1
6	myotube differentiation	GO:0014902	9.4	MYOG MYOD1
7	anatomical structure development	GO:0048856	9.23	TFAP2B PAX7 PAX3 MYOG MYOD1

Molecular functions related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.81	TFAP2B PAX3 MYOG MYOD1 FOXO1
2	DNA-binding transcription factor activity	GO:0003700	9.36	TFAP2B PAX7 PAX3 MYOG MYOD1 FOXO1
3	cis-regulatory region sequence-specific DNA binding	GO:0000987	9.26	TFAP2B MYOG MYOD1

Sources

Sources for Orbit Rhabdomyosarcoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ORB011 MIFTS: 33	Orbit Rhabdomyosarcoma Categories: Bone diseases, Cancer diseases	Data Licensing For inquiries, contact: [email protected]
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