MCID: ORB012
MIFTS: 38

Orbital Cancer

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Orbital Cancer

MalaCards integrated aliases for Orbital Cancer:

Name: Orbital Cancer 12 15
Orbital Neoplasms 44 73
Malignant Neoplasm of Orbit 12
Neoplasm of Orbit Proper 12
Orbital Tumor 12
Orbit Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4143
ICD10 33 C69.6
ICD9CM 35 190.1
MeSH 44 D009918
NCIt 50 C3290 C3562
SNOMED-CT 68 93932000

Summaries for Orbital Cancer

Disease Ontology : 12 A bone cancer that is located in the area behind the eye and derives from the orbit or secondarily derives from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results in the eye pushing forward causing a bulging of the eye called proptosis.

MalaCards based summary : Orbital Cancer, also known as orbital neoplasms, is related to cavernous hemangioma and exophthalmos. An important gene associated with Orbital Cancer is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include eye, bone and lung.

Related Diseases for Orbital Cancer

Diseases related to Orbital Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 cavernous hemangioma 29.2 MB SYP
2 exophthalmos 11.4
3 intraorbital meningioma 11.1
4 luxation of globe 11.0
5 leigh syndrome with leukodystrophy 10.2 NDUFA12 NDUFA2
6 esophageal neuroendocrine tumor 10.1 NCAM1 SYP
7 ovarian large-cell neuroendocrine carcinoma 10.1 NCAM1 SYP
8 lung combined type small cell carcinoma 10.1 NCAM1 SYP
9 hypoganglionosis 10.1 NCAM1 SYP
10 pancreatic endocrine carcinoma 10.1 NCAM1 SYP
11 pancreatic serous cystadenoma 10.1 NCAM1 SYP
12 conventional angiosarcoma 10.1 NCAM1 SYP
13 supratentorial primitive neuroectodermal tumor 10.1 NCAM1 SYP
14 mediastinal cancer 10.1 NCAM1 SYP
15 spermatocele 10.1 NCAM1 SYP
16 multiple mucosal neuroma 10.1 ENO2 NCAM1
17 lung meningioma 10.1 ENO2 NCAM1
18 choriocarcinoma of ovary 10.1 ENO2 NCAM1
19 middle cerebral artery infarction 10.1 ENO2 NCAM1
20 ependymoma 10.1 ENO2 SYP
21 carotid body cancer 10.1 ENO2 SYP
22 malignant sertoli cell tumor 10.1 ENO2 SYP
23 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
24 auditory system cancer 10.1 ENO2 SYP
25 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
26 pancreatic somatostatinoma 10.1 ENO2 SYP
27 small cell carcinoma of the bladder 10.1 ENO2 SYP
28 papillary tumor of the pineal region 10.1 ENO2 SYP
29 sensory organ benign neoplasm 10.1 ENO2 SYP
30 middle ear adenoma 10.1 ENO2 SYP
31 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
32 atypical follicular adenoma 10.1 ENO2 SYP
33 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
34 cerebellum cancer 10.1 ENO2 SYP
35 rete testis neoplasm 10.1 ENO2 NCAM1
36 clear cell ependymoma 10.1 ENO2 SYP
37 cerebral neuroblastoma 10.1 ENO2 SYP
38 cauda equina neoplasm 10.1 ENO2 SYP
39 extraosseous chondrosarcoma 10.1 ENO2 SYP
40 subependymal glioma 10.0 ENO2 SYP
41 malignant teratoma 10.0 ENO2 SYP
42 teratoma 10.0 ENO2 SYP
43 astroblastoma 10.0 ENO2 SYP
44 cerebral ventricle cancer 10.0 ENO2 SYP
45 olfactory nerve neoplasm 10.0 ENO2 SYP
46 pineal gland cancer 10.0 ENO2 SYP
47 autonomic nervous system benign neoplasm 10.0 ENO2 SYP
48 nervous system benign neoplasm 10.0 ENO2 SYP
49 melanotic neuroectodermal tumor 10.0 ENO2 SYP
50 benign ependymoma 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Orbital Cancer:



Diseases related to Orbital Cancer

Symptoms & Phenotypes for Orbital Cancer

Drugs & Therapeutics for Orbital Cancer

Search Clinical Trials , NIH Clinical Center for Orbital Cancer

Cochrane evidence based reviews: orbital neoplasms

Genetic Tests for Orbital Cancer

Anatomical Context for Orbital Cancer

MalaCards organs/tissues related to Orbital Cancer:

41
Eye, Bone, Lung, Kidney, Ovary, Pineal, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Cancer:

19
The Area Behind The Eye

Publications for Orbital Cancer

Articles related to Orbital Cancer:

(show all 15)
# Title Authors Year
1
Can the onset of orbital cancer be the result of a prosthetic eye? ( 28530256 )
2017
2
Two-stage rapid exenteration reconstruction to allow early radiation therapy for an aggressive orbital cancer. ( 28474158 )
2017
3
Orbital cancer: A second cancer in exenterated patients. ( 28812910 )
2017
4
Beveled osteotomies in lateral orbitotomy using a customized rotating bone saw for orbital neoplasms. ( 26000087 )
2015
5
Orbital neoplasms in adults: clinical, radiologic, and pathologic review. ( 24108560 )
2013
6
Modified lateral orbitotomy for removal of orbital neoplasms in two dogs. ( 8140739 )
1994
7
Orbital neoplasms in cats: 21 cases (1974-1990). ( 1429140 )
1992
8
A retrospective analysis of primary eye cancer at the University of Alabama at Birmingham 1958-1988. Part I: Eye and orbital cancer. ( 1813507 )
1991
9
A technique using electrons and photons in the radiotherapy of orbital neoplasms. ( 3128312 )
1987
10
Surface-coil MR imaging of orbital neoplasms. ( 3082141 )
1986
11
Atypical facial pain and orbital cancer. ( 3985856 )
1985
12
Concomitant ocular and orbital neoplasms. ( 7096708 )
1982
13
Unusual orbital neoplasms. ( 5257914 )
1969
14
The production of ocular and orbital neoplasms by intra-arterial inoculation of tumor cells from the Walker carcinosarcoma 256. ( 13966779 )
1962
15
Viruses in relation to orbital neoplasms. ( 18121103 )
1949

Variations for Orbital Cancer

Expression for Orbital Cancer

Search GEO for disease gene expression data for Orbital Cancer.

Pathways for Orbital Cancer

Pathways related to Orbital Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 NCAM1 SYP
2 11.05 NCAM1 SYP
3 10.82 CD207 NCAM1

GO Terms for Orbital Cancer

Cellular components related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 8.96 NDUFA12 NDUFA2
2 mitochondrial respiratory chain complex I GO:0005747 8.62 NDUFA12 NDUFA2

Biological processes related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I assembly GO:0032981 8.62 NDUFA12 NDUFA2

Molecular functions related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.62 NDUFA12 NDUFA2

Sources for Orbital Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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