MCID: ORB012
MIFTS: 34

Orbital Cancer

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Orbital Cancer

MalaCards integrated aliases for Orbital Cancer:

Name: Orbital Cancer 12 15
Orbital Neoplasms 44 73
Malignant Neoplasm of Orbit 12
Neoplasm of Orbit Proper 12
Orbital Tumor 12
Orbit Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4143
ICD10 33 C69.6
ICD9CM 35 190.1
MeSH 44 D009918
NCIt 50 C3290 C3562

Summaries for Orbital Cancer

Disease Ontology : 12 A bone cancer that is located in the area behind the eye and derives from the orbit or secondarily derives from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results in the eye pushing forward causing a bulging of the eye called proptosis.

MalaCards based summary : Orbital Cancer, also known as orbital neoplasms, is related to exophthalmos and intraorbital meningioma. An important gene associated with Orbital Cancer is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Anesthetics and Menthol have been mentioned in the context of this disorder. Affiliated tissues include the area behind the eye, eye and bone.

Related Diseases for Orbital Cancer

Diseases related to Orbital Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 11.2
2 intraorbital meningioma 11.0
3 luxation of globe 10.9
4 leigh syndrome with leukodystrophy 10.5 NDUFA12 NDUFA2
5 esophageal neuroendocrine tumor 10.4 NCAM1 SYP
6 ovarian large-cell neuroendocrine carcinoma 10.4 NCAM1 SYP
7 lung combined type small cell carcinoma 10.4 NCAM1 SYP
8 hypoganglionosis 10.4 NCAM1 SYP
9 pancreatic endocrine carcinoma 10.4 NCAM1 SYP
10 pancreatic serous cystadenoma 10.4 NCAM1 SYP
11 conventional angiosarcoma 10.4 NCAM1 SYP
12 supratentorial primitive neuroectodermal tumor 10.3 NCAM1 SYP
13 mediastinal cancer 10.3 NCAM1 SYP
14 multiple cranial nerve palsy 10.3 NCAM1 NDUFA2
15 spermatocele 10.3 NCAM1 SYP
16 multiple mucosal neuroma 10.3 ENO2 NCAM1
17 lung meningioma 10.3 ENO2 NCAM1
18 choriocarcinoma of ovary 10.3 ENO2 NCAM1
19 adrenal rest tumor 10.2 NCAM1 SYP
20 ureter small cell carcinoma 10.2 ENO2 SYP
21 malignant sertoli cell tumor 10.2 ENO2 SYP
22 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
23 rete testis neoplasm 10.2 ENO2 NCAM1
24 auditory system cancer 10.2 ENO2 SYP
25 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
26 small cell osteogenic sarcoma 10.2 ENO2 EWSR1
27 malignant mesenchymoma 10.2 EWSR1 NCAM1
28 pancreatic somatostatinoma 10.2 ENO2 SYP
29 small cell carcinoma of the bladder 10.2 ENO2 SYP
30 papillary tumor of the pineal region 10.2 ENO2 SYP
31 middle ear adenoma 10.2 ENO2 SYP
32 ovarian carcinosarcoma 10.2 ENO2 SYP
33 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
34 askin's tumor 10.2 ENO2 EWSR1
35 atypical follicular adenoma 10.2 ENO2 SYP
36 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 SYP
37 skin sarcoma 10.2 EWSR1 SYP
38 cerebellum cancer 10.2 ENO2 SYP
39 subependymal glioma 10.2 ENO2 SYP
40 olfactory nerve neoplasm 10.2 ENO2 SYP
41 cerebral neuroblastoma 10.2 ENO2 SYP
42 kidney rhabdoid cancer 10.2 ENO2 EWSR1
43 benign ependymoma 10.2 ENO2 SYP
44 malignant teratoma 10.2 ENO2 SYP
45 astroblastoma 10.2 ENO2 SYP
46 cerebral ventricle cancer 10.2 ENO2 SYP
47 cerebrum cancer 10.2 ENO2 SYP
48 pineal gland cancer 10.1 ENO2 SYP
49 melanotic neuroectodermal tumor 10.1 ENO2 SYP
50 nodular ganglioneuroblastoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Orbital Cancer:



Diseases related to Orbital Cancer

Symptoms & Phenotypes for Orbital Cancer

Drugs & Therapeutics for Orbital Cancer

Drugs for Orbital Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2,Not Applicable
2
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
2 Effectiveness and Possible Complications of Core Needle Biopsy of Orbital Tumors Unknown status NCT01772355 Not Applicable
3 Multiparametric Characterization of Orbital Tumors by MRI Completed NCT01884207
4 Self-adherent Wrap Techniques for Orbital Surgery Completed NCT03415490 Not Applicable
5 Reliability of Hertel Exophthalmometer Measurements Completed NCT01691183
6 MRI Perfusion Curves Typology and Orbital Tumors (PERFORM) Recruiting NCT02434120
7 MRI and Orbital Tumours (MEDORT) Recruiting NCT02401906
8 Ultrasound Exam With Doppler for the Etiological Diagnosis of Orbital Masses (PUCE) Recruiting NCT02678091 Not Applicable
9 Evaluation of Transconjunctival Approach in Management of Orbital Tumors Not yet recruiting NCT03195101 Not Applicable

Search NIH Clinical Center for Orbital Cancer

Cochrane evidence based reviews: orbital neoplasms

Genetic Tests for Orbital Cancer

Anatomical Context for Orbital Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Cancer:

19
The Area Behind The Eye

MalaCards organs/tissues related to Orbital Cancer:

41
Eye, Bone

Publications for Orbital Cancer

Articles related to Orbital Cancer:

# Title Authors Year
1
Can the onset of orbital cancer be the result of a prosthetic eye? ( 28530256 )
2017
2
Two-stage rapid exenteration reconstruction to allow early radiation therapy for an aggressive orbital cancer. ( 28474158 )
2017
3
Orbital cancer: A second cancer in exenterated patients. ( 28812910 )
2017
4
A retrospective analysis of primary eye cancer at the University of Alabama at Birmingham 1958-1988. Part I: Eye and orbital cancer. ( 1813507 )
1991
5
Atypical facial pain and orbital cancer. ( 3985856 )
1985

Variations for Orbital Cancer

Expression for Orbital Cancer

Search GEO for disease gene expression data for Orbital Cancer.

Pathways for Orbital Cancer

Pathways related to Orbital Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 NCAM1 SYP
2 11.05 NCAM1 SYP
3 10.82 CD207 NCAM1

GO Terms for Orbital Cancer

Cellular components related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 8.96 NDUFA12 NDUFA2
2 mitochondrial respiratory chain complex I GO:0005747 8.62 NDUFA12 NDUFA2

Biological processes related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I assembly GO:0032981 8.96 NDUFA12 NDUFA2
2 mitochondrial electron transport, NADH to ubiquinone GO:0006120 8.62 NDUFA12 NDUFA2

Molecular functions related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.62 NDUFA12 NDUFA2

Sources for Orbital Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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