MCID: ORB012
MIFTS: 38

Orbital Cancer

Categories: Bone diseases, Cancer diseases, Eye diseases

Aliases & Classifications for Orbital Cancer

MalaCards integrated aliases for Orbital Cancer:

Name: Orbital Cancer 12 15 17
Orbital Neoplasms 44 70
Malignant Neoplasm of Orbit 12
Neoplasm of Orbit Proper 12
Orbital Tumor 12
Orbit Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4143
ICD9CM 34 190.1
MeSH 44 D009918
NCIt 50 C3290 C3562
SNOMED-CT 67 127003006 363462005
ICD10 32 C69.6
UMLS 70 C0029185 C0153626

Summaries for Orbital Cancer

Disease Ontology : 12 A bone cancer that is located in the area behind the eye and derives from the orbit or secondarily derives from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results in the eye pushing forward causing a bulging of the eye called proptosis.

MalaCards based summary : Orbital Cancer, also known as orbital neoplasms, is related to exophthalmos and hemangioma. An important gene associated with Orbital Cancer is CD34 (CD34 Molecule), and among its related pathways/superpathways are Neuroscience and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include area behind the eye, eye and prostate.

Wikipedia : 73 Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer).... more...

Related Diseases for Orbital Cancer

Diseases related to Orbital Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.5 NF1 CD34 CD1E CD1D CD1C CD1B
2 hemangioma 30.1 SYP ENO2 CD34
3 optic nerve neoplasm 30.1 NF2 NF1
4 orbital disease 29.8 PRTN3 NF1
5 neurofibrosarcoma 29.7 NF2 NF1 ENO2 CD34
6 hemangiopericytoma, malignant 29.6 SYP ENO2 CD34
7 neurilemmoma 29.6 NF2 NF1 ENO2 CD34
8 facial paralysis 29.5 PRTN3 NF2
9 neurofibroma 29.4 SYP NF2 NF1 CD34
10 paraganglioma 29.3 SYP NF1 NCAM1 ENO2
11 meningioma, familial 29.3 SYP NF2 NF1 NCAM1 CD34
12 connective tissue benign neoplasm 29.0 ENO2 CD34 CD1E CD1C CD1B CD1A
13 granuloma annulare 28.8 CD1E CD1D CD1C CD1B CD1A
14 luxation of globe 11.0
15 orbit lymphoma 11.0
16 mechanical ectropion 10.4 NF1 CD34
17 penis sarcoma 10.4 ENO2 CD34
18 angiomyoma 10.4 ENO2 CD34
19 erythema elevatum diutinum 10.4 CD34 CD1E
20 retroperitoneal hemangiopericytoma 10.4 ENO2 CD34
21 atypical neurofibroma 10.4 NF1 CD34
22 breast leiomyosarcoma 10.4 ENO2 CD34
23 congenital granular cell tumor 10.3 ENO2 CD34
24 pulmonary artery leiomyosarcoma 10.3 ENO2 CD34
25 predominantly cortical thymoma 10.3 CD1E CD1A
26 epithelioid malignant peripheral nerve sheath tumor 10.3 NF1 CD34
27 skin granular cell tumor 10.3 NF1 ENO2
28 liver leiomyosarcoma 10.3 ENO2 CD34
29 dendritic cell thymoma 10.3 CD1E CD1A
30 multifocal motor neuropathy 10.3 CD1E CD1A
31 conventional fibrosarcoma 10.3 ENO2 CD34
32 horner's syndrome 10.3 NF1 ENO2
33 parasagittal meningioma 10.3 NF2 CD34
34 ureter transitional cell carcinoma 10.3 NCAM1 ENO2
35 oral hairy leukoplakia 10.3 CD1E CD1A
36 vulvar leiomyoma 10.3 NCAM1 CD34
37 scleredema adultorum 10.3 NCAM1 CD34
38 neurilemmoma of the fifth cranial nerve 10.3 NF2 NF1
39 meninges hemangiopericytoma 10.3 NF2 CD34
40 trigeminal nerve neoplasm 10.3 NF2 NF1
41 epidural spinal canal neoplasm 10.3 NF2 CD34
42 nasal cavity benign neoplasm 10.3 NCAM1 CD34
43 peripheral nerve schwannoma 10.3 NF2 NF1
44 angiomatous meningioma 10.3 NF2 CD34
45 optic nerve sheath meningioma 10.3 NF2 NF1
46 pityriasis rosea 10.3 CD1E CD1A
47 polyp of corpus uteri 10.3 NF2 NF1
48 kimura disease 10.3 CD1E CD1A
49 schwannoma of twelfth cranial nerve 10.3 NF2 NF1
50 hypoglossal nerve disease 10.3 NF2 NF1

Graphical network of the top 20 diseases related to Orbital Cancer:



Diseases related to Orbital Cancer

Symptoms & Phenotypes for Orbital Cancer

Drugs & Therapeutics for Orbital Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Transconjunctival Approach in Management of Orbital Tumors Unknown status NCT03195101
2 Effectiveness and Possible Complications of Core Needle Biopsy of Orbital Tumors Unknown status NCT01772355
3 MRI for the Etiological Diagnosis of Orbital Tumours Completed NCT02401906
4 Multiparametric Characterization of Orbital Tumors by MRI Completed NCT01884207
5 Validation, for Orbital Tumors, of the MRI Perfusion Curves Typology Established for Salivary Tumors Recruiting NCT02434120
6 Contribution of the Quantitative Analysis of the Ultrasound Exam With Doppler for the Etiological Diagnosis of Orbital Masses (PUCE) Recruiting NCT02678091

Search NIH Clinical Center for Orbital Cancer

Cochrane evidence based reviews: orbital neoplasms

Genetic Tests for Orbital Cancer

Anatomical Context for Orbital Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Cancer:

19
Area Behind The Eye

MalaCards organs/tissues related to Orbital Cancer:

40
Eye, Prostate, Bone Marrow, Brain, Colon, Retina

Publications for Orbital Cancer

Articles related to Orbital Cancer:

(show top 50) (show all 98)
# Title Authors PMID Year
1
Experience with Orbital Tumors from a Tertiary Cancer Centre of North East India: A Pathology Perspective. 61
33268934 2020
2
Primary adenoid cystic carcinoma arising from an ectopic lacrimal gland involving both nasal orbits: a rare clinical entity. 61
32912017 2020
3
Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis. 61
31691261 2020
4
Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma: A case report. 61
31577766 2019
5
[Benign Neoplasms of the Orbit]. 61
30999361 2019
6
[Orbital Manifestation of IgG4-Related Disease: Three Case Reports]. 61
30690697 2019
7
The role of ultrasound-guided tissue sampling techniques in the management of extra-ocular orbital lesions. 61
30147738 2018
8
Two-stage rapid exenteration reconstruction to allow early radiation therapy for an aggressive orbital cancer. 61
28474158 2018
9
The 2017 Doyne Lecture: the orbit as a window to systemic disease. 61
29125145 2018
10
Can the onset of orbital cancer be the result of a prosthetic eye? 61
28530256 2017
11
Orbital cancer: A second cancer in exenterated patients. 61
28812910 2017
12
Benign orbital angiomatous tumors with intracranial extension. 61
26260738 2015
13
Schwannoma of the Orbit. 61
28913225 2015
14
Beveled osteotomies in lateral orbitotomy using a customized rotating bone saw for orbital neoplasms. 61
26000087 2015
15
Rare retro-orbital intraconal occurrence of benign schwannoma - a case report. 61
24551692 2013
16
Ocular trauma as the first presentation of Langerhans cell histiocytosis. 61
24961094 2013
17
Orbital neoplasms in adults: clinical, radiologic, and pathologic review. 61
24108560 2013
18
Solitary fibrous tumor of the orbit with multiple cavities. 61
24022362 2013
19
A clinical update and radiologic review of pediatric orbital and ocular tumors. 61
23577029 2013
20
[Benign orbital neoplasms]. 61
21913166 2011
21
Orbital melanoma. 61
21863619 2011
22
A prospective comparison of fine-needle aspiration cytopathology and histopathology in the diagnosis of orbital mass lesions. 61
19628495 2010
23
[Clinical and epidemiological study of lacrimal neoplasms]. 61
19566038 2009
24
[Immunomorphology in the diagnosis of orbital rhabdomyosarcoma]. 61
19517823 2009
25
[Orbital tumors]. 61
19002664 2008
26
Results and resident evaluation of the 2007 American College of Radiology in-training examination in radiation oncology. 61
18812152 2008
27
[The first experience in using radionuclude by single-photon emission computed tomography in the diagnosis of orbital neoplasms]. 61
18756800 2008
28
Orbital solitary fibrous tumor: a case report and review of the literature. 61
18493869 2008
29
[MALT lymphoma of the orbit]. 61
17143610 2008
30
Periorbital and orbital malignancies: methods of management and reconstruction in Iraq. 61
17993883 2007
31
Orbital metastasis of prostate cancer: a case report. 61
17395569 2007
32
Mortality following exenteration for malignant tumours of the orbit. 61
16234450 2005
33
Combined positron emission tomography/computed tomography imaging of orbital lymphoma. 61
16139007 2005
34
The aetiology of optic atrophy in Nigerians--a general hospital clinic study. 61
16033618 2005
35
Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. 61
14638738 2003
36
Arachnoid cyst of the optic nerve: report of two cases and review of the literature. 61
14625493 2003
37
[2. Diagnostic resources and clinical indications]. 61
12934506 2003
38
Potential utility of radiofrequency-induced thermal lesions in the orbit. 61
12918554 2003
39
Equine orbital neoplasia: a review of 10 cases (1983-1998). 61
10769765 2000
40
Orbital ganglioglioma arising from ectopic neural tissue. 61
10653430 2000
41
Peripheral nerve tumors of the orbit. 61
10026738 1999
42
[Automated perimetry analysis of optic nerve compression caused by orbital tumors and tumor-like lesions]. 61
10436997 1997
43
Lateral extensions of the Müller muscle. 61
8953980 1996
44
US and color Doppler imaging of ocular and orbital disease in the pediatric age group. 61
8966285 1996
45
[Therapy of orbital neoplasms in small animals]. 61
8585066 1995
46
Transorbital approaches to the cranial base. 61
7554717 1995
47
[Rare primary malignant orbital neoplasms treated surgically in the I Clinic of Otolaryngology of the Silesian Medical Academy in Katowice in the years 1992-1995]. 61
9454120 1995
48
A review of 340 orbital tumors in children during a 60-year period. 61
8116746 1994
49
Modified lateral orbitotomy for removal of orbital neoplasms in two dogs. 61
8140739 1994
50
[Orbital pathology--I]. 61
8030337 1993

Variations for Orbital Cancer

Expression for Orbital Cancer

Search GEO for disease gene expression data for Orbital Cancer.

Pathways for Orbital Cancer

GO Terms for Orbital Cancer

Cellular components related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.1 SYP PRTN3 NF2 NF1 NCAM1 ENO2
2 extracellular space GO:0005615 9.8 PRTN3 ENO2 CD1E CD1D CD1C CD1B
3 endosome GO:0005768 9.77 CD1E CD1D CD1C CD1B CD1A
4 endosome membrane GO:0010008 9.46 CD1D CD1C CD1B CD1A
5 lysosome GO:0005764 9.35 CD34 CD1E CD1D CD1C CD1B
6 external side of plasma membrane GO:0009897 9.17 NCAM1 CD34 CD1E CD1D CD1C CD1B

Biological processes related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD1A CD1B CD1C CD1D CD1E
2 immune response GO:0006955 9.72 CD1A CD1B CD1C CD1D CD1E
3 adaptive immune response GO:0002250 9.71 CD1A CD1B CD1C CD1E
4 regulation of immune response GO:0050776 9.65 CD34 CD1D CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Orbital Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Orbital Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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