Aliases & Classifications for Orbital Cyst

MalaCards integrated aliases for Orbital Cyst:

Name: Orbital Cyst 12 29 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14233
ICD10 33 H05.81
ICD9CM 35 376.81
SNOMED-CT 68 31021007
UMLS 73 C0155285

Summaries for Orbital Cyst

MalaCards based summary : Orbital Cyst is related to microphthalmia and oculocerebrocutaneous syndrome. An important gene associated with Orbital Cyst is GDF3 (Growth Differentiation Factor 3), and among its related pathways/superpathways are Cardiac Progenitor Differentiation and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include eye, kidney and myeloid, and related phenotypes are embryo and integument

Related Diseases for Orbital Cyst

Diseases related to Orbital Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 microphthalmia 30.1 GDF3 PORCN SOX2
2 oculocerebrocutaneous syndrome 11.9
3 brachial amelia, cleft lip, and holoprosencephaly 11.5
4 microphthalmia associated with colobomatous cyst 11.2
5 complete androgen insensitivity syndrome 10.0 IGF2 PTGDS
6 spontaneous intracranial hypotension 10.0 PTGDS TF
7 intracranial hypotension 10.0 PTGDS TF
8 extragonadal seminoma 10.0 CEACAM5 SOX2
9 cardiomyopathy, familial hypertrophic, 9 10.0 CEACAM5 TF
10 testicular yolk sac tumor 9.9 CEACAM5 TF
11 embryonal carcinoma 9.9 GDF3 IGF2 SOX2
12 femoral neuropathy 9.9 CEACAM5 F2
13 eccrine adenocarcinoma 9.9 CEACAM5 F2
14 epstein-barr virus hepatitis 9.9 F2 TF
15 kwashiorkor 9.9 F2 TF
16 bile duct disease 9.9 CEACAM5 F2
17 analbuminemia 9.8 F2 TF
18 biliary tract disease 9.8 CEACAM5 F2
19 optic disc pit 9.8
20 squamous cell carcinoma 9.8
21 strabismus 9.8
22 germ cell cancer 9.8 IGF2 SOX2
23 large intestine cancer 9.8 CEACAM5 IGF2 SOX2
24 adult respiratory distress syndrome 9.8 F2 TF
25 alcoholic liver cirrhosis 9.8 F2 TF
26 wilson disease 9.8 F2 TF
27 cholangitis 9.8 CEACAM5 F2
28 endocrine gland cancer 9.7 CEACAM5 F2 IGF2
29 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.7
30 proboscis lateralis 9.7
31 encephalocele 9.7
32 cryptophthalmos 9.7
33 chromosome 4p deletion 9.7
34 mechanical strabismus 9.7
35 kidney disease 9.7
36 astrocytoma 9.7
37 cholestasis 9.7
38 meningocele 9.7
39 cysticercosis 9.7
40 polycystic kidney disease 9.7
41 omphalocele 9.7
42 severe cutaneous adverse reaction 9.7
43 polydactyly 9.7
44 aicardi syndrome 9.7
45 conotruncal heart malformations 9.7
46 wolf-hirschhorn syndrome 9.7
47 retinal detachment 9.7
48 kabuki syndrome 1 9.7
49 branchiooculofacial syndrome 9.7

Graphical network of the top 20 diseases related to Orbital Cyst:



Diseases related to Orbital Cyst

Symptoms & Phenotypes for Orbital Cyst

MGI Mouse Phenotypes related to Orbital Cyst:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.55 F2 GDF3 IGF2 PORCN SOX2
2 integument MP:0010771 9.35 F2 IGF2 PORCN PTGDS SOX2
3 mortality/aging MP:0010768 9.17 F2 GDF3 IGF2 PORCN PTGDS SOX2

Drugs & Therapeutics for Orbital Cyst

Search Clinical Trials , NIH Clinical Center for Orbital Cyst

Genetic Tests for Orbital Cyst

Genetic tests related to Orbital Cyst:

# Genetic test Affiliating Genes
1 Orbital Cyst 29

Anatomical Context for Orbital Cyst

MalaCards organs/tissues related to Orbital Cyst:

41
Eye, Kidney, Myeloid, Retina, Liver, Heart

Publications for Orbital Cyst

Articles related to Orbital Cyst:

(show top 50) (show all 74)
# Title Authors Year
1
Transnasal endoscopic resection of pediatric orbital cyst: "How I do it". ( 29336295 )
2018
2
Respiratory Epithelial Orbital Cyst: A Case Report and Literature Review. ( 29651357 )
2018
3
Cyst Excision and Globe Preservation in a Case of Microphthalmos With a Large Orbital Cyst and Visual Potential. ( 30198983 )
2018
4
Management of Congenital Clinical Anophthalmos with Orbital Cyst: A Kinshasa Case Report. ( 30402316 )
2018
5
Doxycycline injection in orbital cyst associated to microphthalmos. ( 28457304 )
2017
6
Unilateral optic disc pit associated with orbital cyst in a child. ( 28860922 )
2017
7
Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume. ( 27315369 )
2016
8
3D Orbital Reconstruction in a Patient with Microphthalmos and a Large Orbital Cyst-A Case Report. ( 26760736 )
2016
9
Microphthalmos, orbital cyst, and missing thumbs: A rare case report. ( 26903731 )
2015
10
Large anterior orbital cyst as a late complication of chalazion surgical drainage. ( 25633879 )
2015
11
Spectral domain optical coherence tomography demonstrates interconnected orbital cyst and chorioretinal coloboma in an adult. ( 25383833 )
2013
12
Optic pit presentation with coexistent orbital cyst. ( 23652289 )
2013
13
Late referred orbital cyst with anophthalmos. ( 22801146 )
2012
14
Diagnostic value of the post-processing technique of multi-slice spiral CT in orbital cyst diseases. ( 22678872 )
2012
15
Recurrent orbital cyst as a late complication of silastic implant for orbital floor fracture repair. ( 21816260 )
2011
16
Novel presentation of Aicardi syndrome with agenesis of the corpus callosum and an orbital cyst. ( 20427798 )
2010
17
Unilateral optic disc pit and orbital cyst in an eye with normal axial length. ( 20489554 )
2010
18
Successful Removal of a Ruptured Orbital Cyst Using 2.3% Sodium Hyaluronate and Indocyanine Green. ( 20337359 )
2010
19
Orbital cyst associated with ocular pit in an adult without microphthalmos. ( 19839891 )
2009
20
Orbital cyst: prenatal diagnosis. ( 19800532 )
2009
21
Patient with congenital optic nerve meningocele presenting with left orbital cyst. ( 19023577 )
2009
22
Orbital cyst of lacrimal derivation presenting as a recurrent orbital abscess in a pediatric patient. ( 19928743 )
2009
23
Disseminated hydatid disease in a child: albendazole treatment of orbital cyst. ( 18988186 )
2008
24
Orbital cyst and bilaterel colobomatous microphthalmos. ( 18952666 )
2008
25
High beta-trace protein concentration in the fluid of an orbital cyst associated with bilateral colobomatous microphthalmos. ( 17510479 )
2007
26
Squamous cell carcinoma presenting as an orbital cyst with radiologic evidence of perineural invasion. ( 18050125 )
2007
27
Giant orbital cyst as a complication of a slipped medial rectus muscle. ( 16491732 )
2006
28
Calcified orbital cyst simulating a malignant lacrimal gland tumor in an adult. ( 15377914 )
2004
29
Bilateral microphthalmos and orbital cyst. ( 12640431 )
2003
30
Bilateral microphthalmos with colobomatous orbital cyst. ( 11926178 )
2002
31
Orbital aspiration as treatment of microphthalmos with orbital cyst: a case report. ( 12450083 )
2002
32
Foreign body orbital cyst. ( 11167301 )
2001
33
Congenital orbital cyst detected and monitored by prenatal ultrasonography. ( 11766026 )
2001
34
Bilateral microphthalmos with colobomatous orbital cyst and de-novo balanced translocation t(3;5). ( 11135495 )
2000
35
Clinical anophthalmos and orbital cyst. ( 10442734 )
1999
36
Giant orbital cyst after strabismus surgery. ( 10428593 )
1999
37
A case of congenital orbital cyst originating from the common sheath of superior rectus and levator palpebrae superioris muscles. ( 10463422 )
1999
38
Pneumo-orbital cyst after orbital fracture repair. ( 9645732 )
1998
39
Infected orbital cyst following exenteration. ( 8878202 )
1996
40
Primary nonkeratinized epithelial (conjunctival) orbital cyst: a case report. ( 8803312 )
1996
41
Orbital cyst of lacrimal sac derivation. ( 8908434 )
1996
42
Bilateral brachial amelia, facial clefts, encephalocele, orbital cyst and omphalocele: a recurrent fetal malformation pattern coming into focus. ( 8723568 )
1996
43
Ultrasonic evaluation of microphthalmos and coloboma. A discussion of 3 cases, with emphasis on microphthalmos with orbital cyst. ( 8741111 )
1996
44
Conjunctival orbital cyst. ( 7947452 )
1994
45
Massive orbital cyst of the lateral rectus muscle after retinal detachment surgery. ( 8305379 )
1993
46
Proboscis lateralis with associated orbital cyst: detailed MR and CT imaging and correlative embryopathy. ( 1414844 )
1992
47
Orbital cyst in a patient with Stevens-Johnson syndrome. ( 1468225 )
1992
48
Microphthalmos with bilateral colobomatous orbital cyst accompanied by polycystic kidney disease and vacuolization of myeloid progenitor cells. ( 1290853 )
1992
49
Bilateral microphthalmos with orbital cyst--case report. ( 1720212 )
1991
50
Microphthalmos with colobomatous orbital cyst in trisomy 13. ( 1881654 )
1991

Variations for Orbital Cyst

Expression for Orbital Cyst

Search GEO for disease gene expression data for Orbital Cyst.

Pathways for Orbital Cyst

Pathways related to Orbital Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 IGF2 SOX2
2 9.95 F2 IGF2

GO Terms for Orbital Cyst

Cellular components related to Orbital Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 F2 GDF3 IGF2 PTGDS TF
2 extracellular region GO:0005576 9.1 CEACAM5 F2 GDF3 IGF2 PTGDS TF

Biological processes related to Orbital Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.56 F2 GDF3 IGF2 SOX2
2 response to wounding GO:0009611 9.16 F2 SOX2
3 eye development GO:0001654 8.96 GDF3 SOX2
4 cellular protein metabolic process GO:0044267 8.8 F2 IGF2 TF

Molecular functions related to Orbital Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 F2 GDF3 IGF2

Sources for Orbital Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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