Orbital Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Orbital Disease, also known as orbit, is related to graves disease 1 and optic nerve disease, and has symptoms including visual disturbance and eye manifestations. An important gene associated with Orbital Disease is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Ciprofloxacin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include eye socket, eye and ciliary ganglion, and related phenotypes are immune system and hematopoietic system

Wikipedia: ⁷⁵ In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are... more...

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Related Diseases for Orbital Disease

Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 525)

#	Related Disease	Score	Top Affiliating Genes
1	graves disease 1	30.7	TSHR TG CRP
2	optic nerve disease	30.4	NF1 ERCC6 CRP CD4
3	hyperthyroidism	30.3	TSHR TG PRTN3 CRP
4	thyroiditis	30.0	TSHR TG CRP
5	igg4-related disease	30.0	PRTN3 MPO CRP CD4 CD1E CD1A
6	polyarteritis nodosa	30.0	PRTN3 MPO CRP
7	neurilemmoma	29.9	SYP NF1 CD34
8	orbital cellulitis	29.9	PRTN3 NCAM1 CRP CD4
9	kimura disease	29.9	CD1E CD1B CD1A
10	papilledema	29.9	SYP CRP CD4
11	endocrine exophthalmos	29.9	TSHR TG CD5
12	enophthalmos	29.8	NF1 FBN1 ERCC6
13	orbital plasma cell granuloma	29.8	TSHR TG PRTN3 CRP
14	scleritis	29.8	PRTN3 MPO CRP
15	vascular cancer	29.7	SYP CD68 CD34
16	sarcoidosis 1	29.6	PRTN3 CRP CD68 CD4
17	granulomatosis with polyangiitis	29.6	PRTN3 MPO CRP CD4 CD34
18	myoblastoma	29.5	SYP CD68
19	lymphoma, non-hodgkin, familial	29.3	NCAM1 MME CD5 CD4 CD34
20	myeloid sarcoma	29.2	NCAM1 MPO CD68 CD34
21	eye disease	29.1	TSHR NF1 FBN1 ERCC6 CRP CD68
22	meningioma, familial	28.8	SYP NF1 NCAM1 CD68 CD34 CD1E
23	langerhans cell histiocytosis	28.6	CD68 CD34 CD1E CD1D CD1C CD1B
24	histiocytosis-lymphadenopathy plus syndrome	28.6	CD68 CD1E CD1D CD1C CD1B CD1A
25	bicipital tenosynovitis	10.4	PRTN3 CRP
26	chronic lacrimal gland enlargement	10.4	PRTN3 CD34
27	acute serous otitis media	10.4	PRTN3 CD34
28	arteritic anterior ischemic optic neuropathy	10.4	PRTN3 CRP
29	liver inflammatory pseudotumor	10.4	CRP CD34
30	sclerosing keratitis	10.4	PRTN3 CRP
31	anterior scleritis	10.4	PRTN3 CRP
32	epithelioid neurofibroma	10.4	NF1 CD34
33	lateral medullary syndrome	10.4	PRTN3 CRP
34	palindromic rheumatism	10.4	PRTN3 CRP
35	deep keratitis	10.4	PRTN3 CRP
36	iodine hypothyroidism	10.4	TSHR TG
37	libman-sacks endocarditis	10.4	PRTN3 CRP
38	thyroid angiosarcoma	10.4	TG CD34
39	inflamed seborrheic keratosis	10.3	CD1E CD1A
40	plexiform schwannoma	10.3	NF1 CD34
41	neurilemmoma of the fifth cranial nerve	10.3	NF1 CD34
42	small intestine leiomyoma	10.3	NF1 CD34
43	trigeminal nerve neoplasm	10.3	NF1 CD34
44	thyroid sarcoma	10.3	TG CD34
45	ventilation pneumonitis	10.3	CRP CD4
46	syphilitic meningitis	10.3	CRP CD4
47	third ventricle chordoid glioma	10.3	CD4 CD34
48	wissler-fanconi syndrome	10.3	PRTN3 CD4
49	brain stem infarction	10.3	PRTN3 CRP
50	endobronchial leiomyoma	10.3	PRTN3 CD34

Graphical network of the top 20 diseases related to Orbital Disease:

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Symptoms & Phenotypes for Orbital Disease

UMLS symptoms related to Orbital Disease:

visual disturbance; eye manifestations

MGI Mouse Phenotypes related to Orbital Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.8	CD1D CD34 CD4 CD5 CD68 CRP
2	hematopoietic system	MP:0005397	9.4	CD1D CD34 CD4 CD5 CD68 ERCC6

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Drugs & Therapeutics for Orbital Disease

Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Ciprofloxacin

Approved, Investigational

Phase 3

85721-33-1, 93107-08-5

2764

Synonyms:

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylate

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylate

1-CYCLOPROPYL-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylate

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid

1-CYCLOPROPYL-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylIC ACID

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylate

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid

1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylate

1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-Cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate

1-Cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Anhydrous, ciprofloxacin hydrochloride

Bacquinor

BAY O 9867 FREE BASE

Baycip

BAY-O-9867 FREE BASE

BAYQ3939

BAY-Q-3939

Bernoflox

CETRAXAL

Ciflox

Cifloxin

CILOXAN

Ciprinol

Cipro

Cipro I.V.

Cipro XL

Cipro XR

CIPROBAY

Ciprocinol

Ciprodar

Ciprofloxacin

Ciprofloxacin dihydrochloride

Ciprofloxacin HCl

Ciprofloxacin hydrochloride

Ciprofloxacin hydrochloride anhydrous

Ciprofloxacin monohydrochloride

Ciprofloxacin monohydrochloride monohydrate

Ciprofloxacina

Ciprofloxacine

Ciprofloxacino

Ciprofloxacinum

Cipromycin

Ciproquinol

Ciproxan

Ciproxin

CPFX

CPR867

Flociprin

Floxin

Hydrochloride anhydrous, ciprofloxacin

Hydrochloride, ciprofloxacin

Monohydrate, ciprofloxacin monohydrochloride

Monohydrochloride monohydrate, ciprofloxacin

Ocuflox

OTIPRIO

Proquin XR

Septicide

VELMONIT

Velomonit

2

Anti-Bacterial Agents

Phase 3

3

Anti-Infective Agents

Phase 3

4

Cytochrome P-450 Enzyme Inhibitors

Phase 3

5

KHK4083

Phase 3

6

Rituximab

Approved

Phase 1, Phase 2

174722-31-7

7

Hormones

Phase 2

8

Calcium, Dietary

Phase 2

9

Antirheumatic Agents

Phase 1, Phase 2

10

Immunologic Factors

Phase 1, Phase 2

11

Calcium

Nutraceutical

Phase 2

7440-70-2

271

12

Nivolumab

Approved

Phase 1

946414-94-4

13

Methotrexate

Approved

Phase 1

1959-05-2, 59-05-2

4112 126941

14

Antineoplastic Agents, Immunological

Phase 1

15

Immune Checkpoint Inhibitors

Phase 1

16

Thrombin

Approved, Investigational

17

Anesthetics

18

Antithrombins

Interventional clinical trials:

(show all 30)

#	Name	Status	NCT ID	Phase	Drugs
1	Obesity Reduction Black Intervention Trial (ORBIT)	Unknown status	NCT00859989	Phase 3
2	A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Subjects With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension and Pharmacokinetic Substudy (ORBIT-3)	Completed	NCT01515007	Phase 3	Ciprofloxacin dispersion for inhalation;Placebo
3	A Two-year Multi-center Phase 3 Study to Investigate the Efficacy and Safety of Secukinumab in Adult Patients With Active, Moderate to Severe Thyroid Eye Disease (ORBIT), With a Randomized, Parallel-group, Double-blind, Placebo-controlled, 16-week Treatment Period, and a Follow-up/Retreatment Period	Recruiting	NCT04737330	Phase 3	Secukinumab;Placebo
4	A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)	Recruiting	NCT05276063	Phase 2, Phase 3	Linsitinib;Placebo
5	A Phase 3, Open-label, 52-week Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab (AMG 451) in Adolescent Subjects Aged ≥ 12 to < 18 Years With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Orbit)	Not yet recruiting	NCT05633355	Phase 3	Rocatinlimab
6	Comparing the Reconstruction of the Orbit Fracture With a Poly Caprolactone / Tri-Calcium Phosphate ( PCL/TCP ) Implant vs. a Titanium Mesh Implant.	Unknown status	NCT01119144	Phase 2
7	A PhaseI/II Prospective, Randomized, Dose-Ranging Pilot Study of Rituximab in the Treatment of Refractory Scleritis and Non-Infectious Orbital Inflammation	Completed	NCT00415506	Phase 1, Phase 2	Rituximab
8	Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant	Completed	NCT00233922	Phase 2
9	Ultra Low Dose 4 Gy Orbital Radiation for Definitive Therapy of Indolent B Cell Lymphoma	Active, not recruiting	NCT02494700	Phase 2	Orbital Radiation
10	A Phase 1B Trial Nivolumab Consolidation Following Completion of High-Dose Methotrexate Containing Induction Chemotherapy in Older (≥ 65) Patients With Primary CNS Lymphoma	Recruiting	NCT04022980	Phase 1	Nivolumab
11	Postoperative Pain of General Anesthesia in Orbital Disease and Ocular Tumor	Unknown status	NCT02704715
12	Lymphoma in the Orbit	Unknown status	NCT01302912
13	Post-enucleation Socket Syndrome Study (PESSS): Part 1 - Three Dimensional Volumetric Assessment of Anophthalmic Sockets With the New Multi-detector Computed Tomographic Technology	Completed	NCT00347282
14	Atypical Intraorbital Dermoid and Epidermoid Cyst: A Single Institution Cross-sectional Retrospective Study	Completed	NCT05410431
15	Ocriplasmin Research to Better Inform Treatment (ORBIT)	Completed	NCT02079883
16	Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (Orbit-AF II)	Completed	NCT01701817
17	Pilot Trial of Radioimmunotherapy With Yttrium 90-Labeled (90Y) Zevalin for Low-Grade Follicular Non-Hodgkin's Lymphoma or MALT of the Orbit/Conjunctiva	Completed	NCT00387023		Rituximab;Zevalin
18	Web-based Intervention With Email Support to Improve Quality of Life in Late Stage Bipolar Disorder (ORBIT): Randomised Controlled Trial	Completed	NCT03197974
19	Increasing Physical Activity Among Breast Cancer Survivors: Use of the ORBIT Model to Refine and Test a Novel Approach to Exercise Promotion Based on Affect-regulation	Completed	NCT04903249
20	Pivotal Trial to Evaluate the Safety and Efficacy of the Diamondback 360°® Orbital Atherectomy System in Treating De Novo, Severely Calcified Coronary Lesions (ORBIT II)	Completed	NCT01092416
21	Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)	Completed	NCT01165710
22	Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases	Completed	NCT03753893
23	Artificial Intelligence-Assisted Facial, Periocular, and Orbital Analysis and Surgical Planning	Completed	NCT04319055
24	Contribution of the Quantitative Analysis of the Ultrasound Exam With Doppler for the Etiological Diagnosis of Orbital Masses (PUCE)	Recruiting	NCT02678091
25	International, Multicenter, Prospective Registry to Collect Data on Orbital Fractures (OFx), Their Primary and Secondary Treatment and Outcome	Recruiting	NCT03887988
26	Outcomes Related to Body Composition in Teens and Adults With Cystic Fibrosis (ORBIT-CF)	Recruiting	NCT04002882
27	Dynamic Contrast Enhanced Magnetic Resonance Imaging for Non-Invasive Diagnostic Work-Up in Solid Tumors of the Eye and Orbit.	Recruiting	NCT01653080
28	Clinical Trial of the Fit Families Multicomponent Obesity Intervention for African American Adolescents and Their Caregivers: Next Step From the ORBIT Initiative	Recruiting	NCT04974554
29	Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition)	Enrolling by invitation	NCT04856410
30	Evaluation of the Efficiency for Orbital Reconstruction After Defect of Bone Substance by Three-dimensional Printed Patient Specific Porous Titanium Implant in Comparison With Autologous Bone Graft	Not yet recruiting	NCT03608280

Search NIH Clinical Center for Orbital Disease

Cochrane evidence based reviews: orbital diseases

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Genetic Tests for Orbital Disease

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Anatomical Context for Orbital Disease

Organs/tissues related to Orbital Disease:

FMA: Eye Socket

MalaCards : Eye, Ciliary Ganglion, Bone, Thyroid, Breast, Lung, Brain

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Publications for Orbital Disease

Articles related to Orbital Disease:

(show top 50) (show all 561)

#	Title	Authors	PMID	Year
1	Ocular manifestations of ANCA-associated vasculitis. ⁶²	Junek ML...Vasculitis Clinical Research Consortium	36440847	2022
2	Erdheim-Chester disease: look it in the eye. An orbital magnetic resonance imaging study. ⁶²	Haroche J...Shor N	35484665	2022
3	DMs-MAFM+EfficientNet: a hybrid model for predicting dysthyroid optic neuropathy. ⁶²	Wu C...Shi B	36129645	2022
4	Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review. ⁶²	Cameron CA...Selva D	34798654	2022
5	Retrobulbar Amphotericin B Injection in Curbing the Progression of COVID Associated Rhino-orbital Cerebral Mucormycosis: A Retrospective Case Series. ⁶²	Pathak M...Nagarkar NM	36246726	2022
6	A Study of Otorhinolaryngological Diseases with Ophthalmic Complications: At a Tertiary Care Center. ⁶²	Shukla A...Kumar B	36452530	2022
7	Repurposing Lenvatinib as A Potential Therapeutic Agent against Thyroid Eye Disease by Suppressing Adipogenesis in Orbital Adipose Tissues. ⁶²	Cheng L...Zhang F	36355477	2022
8	IgG4-Related Disease: sight-threatening orbital disease, spectacular improvement after Rituximab therapy. ⁶²	Pelewicz-Sowa M...Miskiewicz P	36269307	2022
9	Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis. ⁶²	Al-Ghazzawi K...Oeverhaus M	36295095	2022
10	Paediatric orbital lymphoma; a case series and review of the literature. ⁶²	Keren S...Hildebrand GD	36171296	2022
11	Is mucormycosis the end? A comprehensive management of orbit in COVID associated rhino-orbital-cerebral mucormycosis: preserving the salvageable. ⁶²	Keshri A...Agarwal R	36053359	2022
12	Evaluation of extraocular muscles in patients with thyroid associated ophthalmopathy using apparent diffusion coefficient measured by magnetic resonance imaging before and after radiation therapy. ⁶²	Yu W...Huifang Z	34338029	2022
13	[The importance of standardized periorbital steroid injections for thyroid-associated ophthalmopathy]. ⁶²	Li DM...Jiang X	36069084	2022
14	[Chinese guideline on the diagnosis and treatment of thyroid-associated ophthalmopathy (2022)]. ⁶²	Thyroid Group of Chinese Society of Endocrinology of Chinese Medical Association	36069085	2022
15	Advances in magnetic resonance imaging of orbital disease. ⁶²	Tanenbaum RE...Wester ST	34058140	2022
16	Clinical characteristics, diagnosis, and outcomes of orbital biopsies in a single Irish centre. ⁶²	Kneafsey S...Fulcher T	35994223	2022
17	Clinical characteristics and the treatment modalities of Graves' orbitopathy in a tertiary referral center in Turkey: changes over two decades. ⁶²	Ozturk M...Ayvaz G	36030455	2022
18	Evaluation of Orbital Lymphoproliferative and Inflammatory Disorders by Gene Expression Analysis. ⁶²	Al-Ghazzawi K...Oeverhaus M	35955742	2022
19	Outcomes of Transcutaneous Retrobulbar Amphotericin B in Rhino-Orbital-Cerebral Mucormycosis Among Patients Recovering From COVID-19: A Preliminary Experience. ⁶²	Sinha S...Sinha BP	36106303	2022
20	Tissue IgG2/IgG4 Ratio as an Additional Tool to Distinguish IgG4-Related Disease From Other Fibroinflammatory Disorders. ⁶²	Detiger SE...Verdijk RM	35652730	2022
21	Sinonasal Small Cell Carcinoma-Case Series of a Rare Malignancy. ⁶²	Chapurin N...Chandra RK	33090899	2022
22	IgG4-related disease in pediatric patients: a single-center experience. ⁶²	Kaya Akca U...Bilginer Y	33978820	2022
23	Orbital Exenteration for Advanced Periocular Adnexal Malignancies: Curative Versus Palliative Surgical Intent. ⁶²	Malik M...Collin JRO	35093991	2022
24	Transcutaneous retrobulbar injection of amphotericin B in rhino-orbital-cerebral mucormycosis: a review. ⁶²	Nair AG...Dave TV	34720026	2022
25	IgG4-related orbital disease. ⁶²	Vilaltella M...Huerva V	34174214	2022
26	Endonasal Endoscopic Approach for Minimally Invasive Orbital Decompression in Nonthyroid Proptosis-A Scoping Review. ⁶²	Ketharanathan B...Halle B	35331947	2022
27	Lymphoma and inflammatory disorders presenting in the orbit- a comparison of characteristics from a 10-year series in a tertiary hospital. ⁶²	Hunt S...Garrott H	33645420	2022
28	Treatment of orbital lymphatic malformation with oral sirolimus: a case report. ⁶²	Alba-Linero C...Escudero J	35544942	2022
29	Clinical, advanced imaging data and outcome of inflammatory and neoplastic orbital disease in 81 dogs and 16 cats in Australia (2010-2019). ⁶²	Coall SM...Billson FM	34554639	2022
30	Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland. ⁶²	Malick H...Sampath R	33172316	2022
31	Conjunctival Infiltration in a Child as a Rare Manifestation of IgG4-Related Disease. ⁶²	Qi SR...Legare ME	34050069	2022
32	Experience on rhino-orbital mucormycosis from a tertiary care hospital in the first wave of COVID-19: An Indian perspective. ⁶²	Saluja G...Bajaj MS	35400798	2022
33	Pediatric Subcutaneous Panniculitis-like T-cell Lymphoma of the Orbit. ⁶²	Tong JY...Tumuluri K	34652312	2022
34	Transcutaneous retrobulbar amphotericin-B (TRAMB) injection in orbital mucormycosis. ⁶²	Singh P...Raj A	35361668	2022
35	Normative orbital measurements in an Australian cohort on computed tomography. ⁶²	Rana K...Selva D	35232320	2022
36	Feline ophthalmomyiasis externa caused by Cuterebra larvae: four cases (2005-2020). ⁶²	Schlesener BN...Ledbetter EC	33988048	2022
37	Concomitant adult onset xanthogranuloma and IgG4-related orbital disease: a rare occurrence. ⁶²	Andron AA...Reddy HS	32847452	2022
38	Radiographic analysis of fatty infiltration of the extraocular muscles in thyroid eye disease. ⁶²	Cohen LM...Yoon MK	32878536	2022
39	A fungal epidemic amidst a viral pandemic: Risk factors for development of COVID-19 associated rhino-orbital-cerebral mucormycosis in India. ⁶²	Vasanthapuram VH...Shinde CA	35192435	2022
40	Cumulative Mortality and Factors Associated With Outcomes of Mucormycosis After COVID-19 at a Multispecialty Tertiary Care Center in India. ⁶²	Choksi T...Pawar N	34882192	2022
41	Association of Age-adjusted Charlson Comorbidity Index With Orbital Fungal Disease Outcomes. ⁶²	Kupcha AC...Mawn LA	34085995	2022
42	Retrobulbar injection of amphotericin B using intravenous cannula for post-COVID-19 rhino-orbital mucormycosis. ⁶²	Murthy R...Desai S	34937263	2022
43	Reduction of Interhemispheric Homotopic Connectivity in Cognitive and Visual Information Processing Pathways in Patients With Thyroid-Associated Ophthalmopathy. ⁶²	Qi CX...Huang X	35865354	2022
44	Repurposing super saturated potassium iodide as an adjunctive treatment in mucormycosis: An exposition in a diabetic patient with rhino-orbital disease with cutaneous extension. ⁶²	Sardana K...Majumder A	34708500	2022
45	Anaplastic Thyroid Carcinoma with Ocular Then Orbital Metastases. ⁶²	Tran T...Tao J	35350232	2022
46	Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves' Ophthalmopathy by Targeting Orbital Fibroblasts. ⁶²	Yang S...Yang H	35663306	2022
47	Changes of Volume Parameters in the Treatment of Graves Ophthalmopathy by Endoscopic Transethmoidal Decompression of the Orbital Inner Wall Combined with Fat Decompression. ⁶²	Fu W	36082172	2022
48	Immunoglobulin G4-related orbital disease in an 8-year-old girl. ⁶²	Hoshiyama S...Nakazawa Y	35278255	2022
49	Noninvasive Machine Learning Screening Model for Dacryocystitis Based on Ocular Surface Indicators. ⁶²	Song X...Xiao C	34267140	2022
50	Rhino-orbital mucormycosis following COVID-19 in previously non-diabetic, immunocompetent patients. ⁶²	Nair AG...Shinde CA	34338124	2021

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Genes for Orbital Disease

Genes related to Orbital Disease (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	9.38	DISEASES inferred ¹⁴ ¹⁴
2	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	6.73	DISEASES inferred ¹⁴
3	CRP	C-Reactive Protein	Protein Coding	6.15	DISEASES inferred ¹⁴
4	PRTN3	Proteinase 3	Protein Coding	5.91	DISEASES inferred ¹⁴
5	CD34	CD34 Molecule	Protein Coding	5.8	DISEASES inferred ¹⁴
6	NF1	Neurofibromin 1	Protein Coding	5.8	DISEASES inferred ¹⁴
7	CD1A	CD1a Molecule	Protein Coding	5.42	DISEASES inferred ¹⁴
8	CD1E	CD1e Molecule	Protein Coding	5.4	DISEASES inferred ¹⁴
9	CD1B	CD1b Molecule	Protein Coding	5.4	DISEASES inferred ¹⁴
10	TG	Thyroglobulin	Protein Coding	5.36	DISEASES inferred ¹⁴
11	CD1C	CD1c Molecule	Protein Coding	5.28	DISEASES inferred ¹⁴
12	CD4	CD4 Molecule	Protein Coding	5.25	DISEASES inferred ¹⁴
13	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	5.19	DISEASES inferred ¹⁴
14	CD5	CD5 Molecule	Protein Coding	5.15	DISEASES inferred ¹⁴
15	FBN1	Fibrillin 1	Protein Coding	5.12	DISEASES inferred ¹⁴
16	MME	Membrane Metalloendopeptidase	Protein Coding	5.12	DISEASES inferred ¹⁴
17	MPO	Myeloperoxidase	Protein Coding	5.11	DISEASES inferred ¹⁴
18	CD68	CD68 Molecule	Protein Coding	5.11	DISEASES inferred ¹⁴
19	CD1D	CD1d Molecule	Protein Coding	5.1	DISEASES inferred ¹⁴
20	SYP	Synaptophysin	Protein Coding	4.96	DISEASES inferred ¹⁴

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Variations for Orbital Disease

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Expression for Orbital Disease

Search GEO for disease gene expression data for Orbital Disease.

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Pathways for Orbital Disease

Pathways related to Orbital Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.65	PRTN3 NCAM1 MPO MME CRP CD68
2	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.68	CD34 CD1D CD1C CD1B CD1A
3	C-MYB transcription factor network ⁶¹	11.46	PRTN3 MPO CD4 CD34
4	Innate Lymphoid Cells Differentiation ⁶⁵	11.45	NCAM1 CD4 CD34
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	NCAM1 MME CD4 CD34 CD1D CD1C
6	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.29	NCAM1 MPO MME CD68 CD5 CD4

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GO Terms for Orbital Disease

Cellular components related to Orbital Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016021	10.47	CD1A CD1B CD1C CD1D CD1E CD34
2	membrane	GO:0016020	10.47	CD1A CD1B CD1C CD1D CD1E CD34
3	extracellular space	GO:0005615	10.4	TG PRTN3 MPO FBN1 CRP CD1E
4	cell surface	GO:0009986	10.1	TSHR NCAM1 MME CD4 CD34 CD1D
5	plasma membrane	GO:0005886	10.07	CD1A CD1C CD1D CD1E CD34 CD4
6	plasma membrane	GO:0005887	10.07	CD1A CD1C CD1D CD1E CD34 CD4
7	endosome membrane	GO:0010008	10.02	CD1A CD1B CD1C CD1D CD68
8	lysosome	GO:0005764	9.93	CD1B CD1C CD1D CD1E CD34 CD68
9	external side of plasma membrane	GO:0009897	9.58	NCAM1 CD5 CD4 CD34 CD1E CD1D

Biological processes related to Orbital Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.02	CD4 CD1E CD1D CD1C CD1B CD1A
2	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.85	CD1A CD1B CD1C CD1D CD1E
3	immune system process	GO:0002376	9.8	CD4 CD1E CD1D CD1C CD1B CD1A
4	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.65	CD1E CD1D CD1C CD1B CD1A
5	T cell selection	GO:0045058	9.56	CD4 CD1D
6	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.32	CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Orbital Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.85	CD1E CD1D CD1C CD1B CD1A
2	exogenous lipid antigen binding	GO:0030884	9.65	CD1E CD1D CD1C CD1B CD1A
3	endogenous lipid antigen binding	GO:0030883	9.32	CD1E CD1D CD1C CD1B CD1A

Sources

Sources for Orbital Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

ORBIT MCID: ORB013 MIFTS: 44	Orbital Disease (ORBIT) Categories: Bone diseases, Eye diseases, Muscle diseases	Data Licensing For inquiries, contact: [email protected]
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Orbital Disease (ORBIT)

Aliases & Classifications for Orbital Disease

MalaCards integrated aliases for Orbital Disease:

Classifications:

External Ids:

Summaries for Orbital Disease

Related Diseases for Orbital Disease

Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Orbital Disease:

Symptoms & Phenotypes for Orbital Disease

UMLS symptoms related to Orbital Disease:

MGI Mouse Phenotypes related to Orbital Disease:

Drugs & Therapeutics for Orbital Disease

Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: orbital diseases

Genetic Tests for Orbital Disease

Anatomical Context for Orbital Disease

Organs/tissues related to Orbital Disease:

Publications for Orbital Disease

Articles related to Orbital Disease:

Genes for Orbital Disease

Genes related to Orbital Disease (0 elite genes):

Variations for Orbital Disease

Expression for Orbital Disease

Pathways for Orbital Disease

Pathways related to Orbital Disease according to GeneCards Suite gene sharing:

GO Terms for Orbital Disease

Cellular components related to Orbital Disease according to GeneCards Suite gene sharing:

Biological processes related to Orbital Disease according to GeneCards Suite gene sharing:

Molecular functions related to Orbital Disease according to GeneCards Suite gene sharing:

Sources for Orbital Disease