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ORBIT
MCID: ORB013
MIFTS: 42

Orbital Disease (ORBIT)

Categories: Bone diseases, Eye diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Orbital Disease

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MalaCards integrated aliases for Orbital Disease:

Name: Orbital Disease 12 15
Orbital Diseases 44
Orbit 70

Classifications:

MalaCards categories:
Anatomical: Eye diseases Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:930
ICD9CM 34 376.9
MeSH 44 D009916
SNOMED-CT 67 267746003
UMLS 70 C0029182
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Summaries for Orbital Disease

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Disease Ontology : 12 An adnexa disease that is located in the eye socket.

MalaCards based summary : Orbital Disease, also known as orbital diseases, is related to exophthalmos and optic nerve disease, and has symptoms including visual disturbance and eye manifestations. An important gene associated with Orbital Disease is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Lidocaine and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye socket, eye and thyroid, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are... more...

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Related Diseases for Orbital Disease

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Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.5 TSHR TG PRTN3 NF1
2 optic nerve disease 30.1 NF1 ERCC6 CRYAA CRP CD4
3 orbital cancer 30.0 PRTN3 NF1
4 acute dacryoadenitis 29.9 CRP ACE
5 ocular motility disease 29.9 PHOX2A KIF21A CRYAA
6 endocrine exophthalmos 29.8 TG CD5
7 orbital cellulitis 29.7 CRYAA CRP CD4
8 eye disease 29.7 TSHR MIR193A ERCC6 CRYAA CRP CD4
9 papilledema 29.6 CRP CD4 ACE
10 graves' disease 29.5 TSHR TG IL16 CTLA4
11 hyperthyroidism 29.5 TSHR TG PRTN3 CTLA4 CRP
12 scleritis 29.5 PRTN3 CTLA4 CRP
13 strabismus 29.5 TSHR PHOX2A NF1 KIF21A CRYAA
14 keratitis, hereditary 29.4 PHOX2A KIF21A CRYAA CD4
15 granulomatosis with polyangiitis 29.4 PRTN3 CTLA4 CRP CD4
16 myxedema 29.3 TSHR TG CTLA4
17 orbital plasma cell granuloma 29.3 TSHR PRTN3 CTLA4 CRP
18 thyroiditis 29.2 TSHR TG CTLA4 CRP
19 enophthalmos 29.0 SLC39A13 PHOX2A NF1 FBN1 ERCC6 EPB41L1
20 hypothyroidism 28.6 TSHR TG CTLA4 CRP ACE
21 purulent acute otitis media 10.4 PRTN3 CRP
22 frontal sinusitis 10.4 PRTN3 CRP
23 bicipital tenosynovitis 10.4 PRTN3 CRP
24 ethmoid sinusitis 10.4 PRTN3 CRP
25 interstitial keratitis 10.3 CRYAA CRP
26 hemopericardium 10.3 FBN1 CRP
27 subclavian artery aneurysm 10.3 NF1 FBN1
28 subungual glomus tumor 10.3 NF1 CRP
29 iodine hypothyroidism 10.3 TSHR TG
30 myotonic cataract 10.3 PHOX2A KIF21A
31 facial hemiatrophy 10.3 KIF21A CRP
32 marcus gunn phenomenon 10.3 PHOX2A KIF21A
33 thyroid crisis 10.3 TSHR TG
34 toxic diffuse goiter 10.3 TSHR TG
35 dacryocystocele 10.3 PRTN3 NF1
36 chronic inflammation of lacrimal passage 10.3 PRTN3 NF1
37 fibrosis of extraocular muscles, congenital, 2 10.3 PHOX2A KIF21A
38 branch retinal artery occlusion 10.3 PRTN3 CRYAA CRP
39 central retinal artery occlusion 10.3 PRTN3 CRYAA CRP
40 subacute bacterial endocarditis 10.3 PRTN3 CRP
41 pulmonary aspergilloma 10.3 TG CRP
42 paralytic squint 10.3 PHOX2A KIF21A
43 athyreosis 10.3 TSHR TG
44 mastoiditis 10.3 PRTN3 CRP
45 cogan syndrome 10.3 PRTN3 CRP
46 lens disease 10.3 FBN1 ERCC6 CRYAA
47 tracheal disease 10.3 PRTN3 FBN1 CRP
48 hypertropia 10.2 PHOX2A KIF21A
49 chondromalacia 10.2 PRTN3 CRP
50 panophthalmitis 10.2 CRP CD4

Graphical network of the top 20 diseases related to Orbital Disease:



Diseases related to Orbital Disease
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Symptoms & Phenotypes for Orbital Disease

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UMLS symptoms related to Orbital Disease:


visual disturbance; eye manifestations

MGI Mouse Phenotypes related to Orbital Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ACE CD4 CD5 CTLA4 ERCC6 FBN1
2 immune system MP:0005387 9.73 ACE CD4 CD5 CRP CTLA4 ERCC6
3 nervous system MP:0003631 9.36 ACE CD4 CD5 EPB41L1 ERCC6 FBN1
Sources

Drugs & Therapeutics for Orbital Disease

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Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Pancrelipase Approved, Investigational Phase 4 53608-75-6
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
11
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
12
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
13
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
14 Anesthetics Phase 4
15 Pharmaceutical Solutions Phase 4
16 Anesthetics, Local Phase 4
17 Neurotransmitter Agents Phase 4
18 abobotulinumtoxinA Phase 4
19 Cholinergic Agents Phase 4
20 Botulinum Toxins, Type A Phase 4
21 Botulinum Toxins Phase 4
22 Sodium Channel Blockers Phase 4
23 Anti-Arrhythmia Agents Phase 4
24 Diuretics, Potassium Sparing Phase 4
25 Neuromuscular Blocking Agents Phase 4
26 Cholinergic Antagonists Phase 4
27 Neuromuscular Nondepolarizing Agents Phase 4
28 Analgesics Phase 4
29 pancreatin Phase 4
30 Chelating Agents Phase 4
31 Liver Extracts Phase 4
32 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 4
33 Hormones Phase 4
34 Gastrointestinal Agents Phase 4
35 Methylprednisolone Acetate Phase 4
36 Antiemetics Phase 4
37 Neuroprotective Agents Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 Protective Agents Phase 4
40 Hormone Antagonists Phase 4
41 glucocorticoids Phase 4
42 Anti-Inflammatory Agents Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Anti-Bacterial Agents Phase 4
45 Anti-Infective Agents Phase 4
46 Clavulanic Acids Phase 4
47 beta-Lactamase Inhibitors Phase 4
48
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
49
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
50
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3

Interventional clinical trials:

(show top 50) (show all 178)
# Name Status NCT ID Phase Drugs
1 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
2 The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients. Unknown status NCT01704248 Phase 4
3 A Double Blinded Randomized Controlled Trial to Compare the Efficacy, Time to Onset, and Duration of Two Botulinum Type A Exotoxins (Onabotulinum Toxin A and Abobotulinum Toxin A) in the Treatment of "Crow's Feet." Completed NCT01529788 Phase 4 Right lateral orbital injection of Botox Cosmetic or Dysport;Left lateral orbital injection of Botox Cosmetic or Dysport
4 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at National Eye Centre, Kaduna. Nigeria Completed NCT02150460 Phase 4
5 Ablative Fractional Lasers (CO2 and Er:YAG): A Randomized Controlled Blinded Split-face Trial of the Treatment of Peri-orbital Rhytides Completed NCT00990431 Phase 4
6 Comparison of Clinical Outcome Parameters, the Patient Benefit Index (PBI) and Patient Satisfaction After Ablative Fractional Laser Treatment of Peri-orbital Rhytides Completed NCT00994474 Phase 4
7 Comparison of Great Occipital Nerve and Supraorbital Nerve Blockade Treatment Methods Individually and in Combination With Placebo in an Acute Migraine Attack in the Emergency Department, a Prospective, Double Blind, Randomized Controlled Study Completed NCT04491474 Phase 4 Lidocaine Hydrochloride;Placebo
8 Efficacy and Safety of Low Dose Atracurium Added to Lidocaine, Bupivacaine and Hyaluronidase Mixture in Percaruncular Peribulbar Anesthesia for High Myopes Undergoing Phacoemulsification: A Randomized Controlled Trial. Completed NCT03243500 Phase 4 Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
9 Postoperative Pain Control After Enucleation or Evisceration, a Double-Masked Randomized Controlled Trial of Standard Versus Slow-release Bupivacaine Recruiting NCT02381353 Phase 4 Bupivacaine
10 Evaluation of Gadoterate in Patients With Renal Dysfunction Active, not recruiting NCT02382380 Phase 4 Gadoterate
11 VISmodegib for ORbital and Periocular Basal Cell Carcinoma (VISORB) Active, not recruiting NCT02436408 Phase 4 Vismodegib
12 A Phase IV, Randomized, Multi-center Clinical Trial to Compare the Efficacy of Orbital Radiotherapy in Association With Intravenous Glucocorticoids vs Intravenous Glucocorticoids Alone for Moderately Severe and Active Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
13 Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures (Mandibular Fractures, Zygomaticoorbital Fractures, Isolated Orbital Blow-out Fractures and LeFort I/II/III Fractures): 1 Day vs. 5 Days: a Prospective, Randomized, Double Blind and Placebo Controlled Study (Phase IV) Terminated NCT01583062 Phase 4 Amoxicillin/clavulanic acid;Amoxicillin plus placebo
14 ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL Goals Withdrawn NCT00396240 Phase 4 Rosuvastatin
15 Obesity Reduction Black Intervention Trial (ORBIT) Unknown status NCT00859989 Phase 3
16 Prosthetic Motility and Complications in Pegged Versus Unpegged Hydroxyapatite Orbital Implants Unknown status NCT00371280 Phase 2, Phase 3
17 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Subjects With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension and Pharmacokinetic Substudy (ORBIT-3) Completed NCT01515007 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
18 Infra-orbital Nerve Block for Post Operative Analgesia in Young Children Undergoing Pediatric Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
19 PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial Completed NCT02374060 Phase 3 Periocular triamcinolone 40 mg;Intravitreal triamcinolone 4 mg;Dexamethasone intravitreal implant
20 Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial Recruiting NCT03958344 Phase 3 Prednisolone;Triamcinolone + Betamethason
21 GALOP II Protocol for the Treatment of Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
22 The Role of Optic Nerve Sheath Fenestration in Leukemic Patients Having Increased Intracranial Pressure Active, not recruiting NCT04431882 Phase 2, Phase 3
23 Attenuation Corrected Cardiac SPECT Using the GE Hawkeye Camera System Terminated NCT00587730 Phase 2, Phase 3
24 Comparing the Reconstruction of the Orbit Fracture With a Poly Caprolactone / Tri-Calcium Phosphate ( PCL/TCP ) Implant vs. a Titanium Mesh Implant. Unknown status NCT01119144 Phase 2
25 A Pilot Study Using an NMDA Antagonist to Modulate Transcranial Direct Current Stimulation (tDCS) Effects on Auditory Sensory Memory Processing Unknown status NCT02426983 Phase 1, Phase 2 Dextromethorphan
26 A Prospective Single Arm Trial of Involved Field Radiotherapy Alone for Stage I-II Low Grade Non-gastric Marginal Zone Lymphoma Unknown status NCT00377195 Phase 2
27 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
28 A PhaseI/II Prospective, Randomized, Dose-Ranging Pilot Study of Rituximab in the Treatment of Refractory Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
29 Enhancing Developmental Motor Plasticity After Perinatal Stroke With Transcranial Direct Current Stimulation Completed NCT02170285 Phase 2
30 A Single-masked, Placebo Controlled, Multi-center Pilot Study to Determine the Safety and Efficacy of Orbital Injections of a Fixed Dose of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease Completed NCT00954057 Phase 2 LIPO-102;Placebo
31 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
32 A Comparative Study of Recessive Spherical Headed Silicone Intubation and Dacryocystorhinostomy Under Nasal Endoscopy in the Treatment of Nasolacrimal Duct Obstruction Completed NCT02636257 Phase 1, Phase 2
33 Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Scalp Block and Scalp Infiltration to Control Post Craniotomy Pain Completed NCT02866409 Phase 2 Dexmedetomidine;Bupivacaine
34 Randomized Phase II Trial On Primary Chemotherapy With High-Dose Methotrexate And High-Dose Cytarabine With Or Without Thiotepa, And With Or Without Rituximab, Followed By Brain Irradiation Vs. High-Dose Chemotherapy Supported By Autologous Stem Cells Transplantation For Immunocompetent Patients With Newly Diagnosed Primary CNS Lymphoma Completed NCT01011920 Phase 2 Methotrexate;Ara-C;Rituximab;Thiotepa;BCNU
35 A Multi-center, Open Label, Multiple Dose, Phase II Trial to Demonstrate the Safety of DWP-450 in Adult Subjects for Treatment of Moderate-to-severe Glabellar Lines. Completed NCT02184988 Phase 2
36 Ultra Low Dose 4 Gy Orbital Radiation for Definitive Therapy of Indolent B Cell Lymphoma Recruiting NCT02494700 Phase 2 Orbital Radiation
37 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
38 Ipilimumab and Nivolumab in Combination With Immunoembolization for the Treatment of Metastatic Uveal Melanoma Recruiting NCT03472586 Phase 2 Embolization Therapy
39 Interventions to Decrease the Impact of Post-Operative Ileus After Liver Transplant or Resection Surgery Completed NCT01156129 Phase 1 stool softener
40 Investigation of Cocaine Addiction Using mGluR5 PET and fMRI Recruiting NCT03471182 Phase 1 Cocaine Self-adminstration
41 Postoperative Pain of General Anesthesia in Orbital Disease and Ocular Tumor Unknown status NCT02704715
42 Efficacy of Endoscopic Transantral Versus Transorbital Surgical Approaches in the Repair of Orbital Blow-Out Fractures-Randomized Clinical Trial. Unknown status NCT03011047
43 Evaluation of Transconjunctival Approach in Management of Orbital Tumors Unknown status NCT03195101
44 Lymphoma in the Orbit Unknown status NCT01302912
45 Orbital Fractures Measurement: Intraoperative Versus Computed Tomography (CT) Scan Unknown status NCT01464541
46 Fetal Orbital Measurements by 3D Ultrasound Unknown status NCT01594944
47 the Effect of Using the Tyransconjunctival Approach Alone Versus Using Transconjunctival Approach Together With Lateral Canthotomy in Orbital Fractures Unknown status NCT03813732
48 Fast Magnetic Resonance Imaging as Compared to Computed Tomography Scan in Pediatric Orbital Cellulitis Imaging Unknown status NCT02711436
49 Resorbable Polymer Plates in Repair of Blowout Orbital Floor Fractures Unknown status NCT03683615
50 Transcranial Direct Current Stimulation to Lower Neuropathic Pain and Fatigue in People With Multiple Sclerosis Unknown status NCT03870048

Search NIH Clinical Center for Orbital Disease

Cochrane evidence based reviews: orbital diseases

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Genetic Tests for Orbital Disease

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Anatomical Context for Orbital Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Disease:

19
Eye Socket

MalaCards organs/tissues related to Orbital Disease:

40
Eye, Thyroid, Bone, Skin, Ciliary Ganglion, Thymus, Lymph Node
Sources

Publications for Orbital Disease

About this section

Articles related to Orbital Disease:

(show top 50) (show all 691)
# Title Authors PMID Year
1
Histopathologic Findings in Idiopathic Orbital Myositis. 61
32926913 2021
2
Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease. 61
32501880 2021
3
The role of ultrasonography in differential diagnosis of orbital lesions. 61
32166724 2021
4
Re: concomitant adult onset xanthogranuloma and IgG4-related orbital disease: a rare occurrence. 61
33043756 2021
5
Re: concomitant adult onset xanthogranuloma and IgG4-related orbital disease: A rare occurrence. 61
33034247 2021
6
Sarcoid-like granulomatous orbitopathy-presentation, systemic involvement and clinical outcome. 61
32317795 2021
7
Enrichment of IGF-1R and PPARγ signalling pathways in orbital inflammatory diseases: steps toward understanding pathogenesis. 61
33637620 2021
8
Lymphoma and inflammatory disorders presenting in the orbit- a comparison of characteristics from a 10-year series in a tertiary hospital. 61
33645420 2021
9
Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis. 61
32358156 2021
10
The feasibility of quantitative MRI of extra-ocular muscles in myasthenia gravis and Graves' orbitopathy. 61
32893386 2021
11
Morphologic Cross-Sectional Imaging Features of IgG4-Related Orbitopathy in Comparison to Ocular Adnexal Lymphoma. 61
33737803 2021
12
Bag-of-features-based radiomics for differentiation of ocular adnexal lymphoma and idiopathic orbital inflammation from contrast-enhanced MRI. 61
32789530 2021
13
Radiation-Induced Hyalinizing Clear Cell Carcinoma of the Orbit. 61
32427738 2021
14
Ocular side effects of checkpoint inhibitors. 61
33440195 2021
15
Automatic orbital computed tomography coordinating method and quantitative error evaluation based on signed distance field. 61
32252533 2021
16
Retrobulbar metastasis of breast primary- Once in a blue moon lesion. 61
33475618 2020
17
A prospective randomized controlled clinical trial of Pingmu Decoction combined with acupuncture in the treatment of non-active thyroid-related ophthalmopathy. 61
33371126 2020
18
Compressive optic neuropathy with vision loss due to IgG4-related orbital disease. 61
31590594 2020
19
Immunoglobulin G4-Related Orbital Disease with Bilateral Optic Perineuritis and Maxillary Nerves Involvement: A Case Report. 61
33068267 2020
20
[Diseases and Surgery of the Orbit]. 61
33307575 2020
21
[Management of orbital inflammatory disorders in internal medicine: New findings resulting from a retrospective study of 31 consecutive patients]. 61
32861532 2020
22
Orbital disease in neuro-ophthalmology. 61
33009078 2020
23
Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland. 61
33172316 2020
24
Normative Exophthalmometry Measurements Vary Among Ethiopian Adults and the Major Ethiopian Ethnic Groups. 61
32467519 2020
25
[A summary of oculoplastic and orbital surgery in China in the past 70 years]. 61
33152838 2020
26
The Alberta standardized orbital technique in the management of spheno-orbital meningiomas. 61
33008278 2020
27
Post-traumatic enophthalmos secondary to orbital fat atrophy: a volumetric analysis. 61
31726012 2020
28
Sinonasal Small Cell Carcinoma-Case Series of a Rare Malignancy. 61
33090899 2020
29
Measurement of proptosis using computed tomography based three-dimensional reconstruction software in patients with Graves' orbitopathy. 61
32883985 2020
30
Orbital disease in neuro-ophthalmology. 61
32897917 2020
31
Retinal and Optic Nerve Deformations Due to Orbital Versus Intracranial Venous Hypertension. 61
32956232 2020
32
Radiographic analysis of fatty infiltration of the extraocular muscles in thyroid eye disease. 61
32878536 2020
33
[Use of the Multidisciplinary Specialised Case Conference at the Freiburg Orbital Centre]. 61
32016941 2020
34
Concomitant adult onset xanthogranuloma and IgG4-related orbital disease: a rare occurrence. 61
32847452 2020
35
Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases. 61
32613849 2020
36
Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit. 61
32751135 2020
37
Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases. 61
32083541 2020
38
Case Report: A Rare Case of Silent Sinus Syndrome and Vertical Diplopia. 61
32697554 2020
39
Subtotal Exenteration of the Orbit for Benign Orbital Disease. 61
32224777 2020
40
T2 mapping of the extraocular muscles in healthy volunteers: preliminary research on scan-rescan and observer-observer reproducibility. 61
31581780 2020
41
Carcinoid Tumors of the Orbit and Ocular Adnexa. 61
32496392 2020
42
Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review. 61
32427727 2020
43
IgG4-related disease: a clinical perspective. 61
32348524 2020
44
Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis. 61
31691261 2020
45
The expanded endonasal approach in pediatric skull base surgery: A review. 61
32337363 2020
46
Prostaglandin analogues: A double-edged sword in orbital glaucoma disease management. 61
32043370 2020
47
A Comparative Study of Clinical vs. Digital Exophthalmometry Measurement Methods. 61
32280513 2020
48
Microarray Data of Lacrimal Gland Implicates Dysregulated Protein Processing in Endoplasmic Reticulum in Graves' Ophthalmopathy. 61
33613444 2020
49
An accurate interactive segmentation and volume calculation of orbital soft tissue for orbital reconstruction after enucleation. 61
31842802 2019
50
Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT. 61
31867079 2019
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Variations for Orbital Disease

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Expression for Orbital Disease

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Search GEO for disease gene expression data for Orbital Disease.
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Pathways for Orbital Disease

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Pathways related to Orbital Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Thyroxine (Thyroid Hormone) Production 1
9.4 TSHR TG
Sources

GO Terms for Orbital Disease

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Biological processes related to Orbital Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sympathetic nervous system development GO:0048485 8.62 PHOX2A NF1
Sources

Sources for Orbital Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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