ORBIT
MCID: ORB013
MIFTS: 38

Orbital Disease (ORBIT)

Categories: Eye diseases

Aliases & Classifications for Orbital Disease

Summaries for Orbital Disease

Disease Ontology : 12 An adnexa disease that is located in the eye socket.

MalaCards based summary : Orbital Disease, also known as orbital diseases, is related to exophthalmos and intracranial sinus thrombosis, and has symptoms including visual disturbance and eye manifestations. An important gene associated with Orbital Disease is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor). The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and ciliary ganglion, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : 77 In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are... more...

Related Diseases for Orbital Disease

Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 29.3 RHNO1 TSHR
2 intracranial sinus thrombosis 10.0 PGBD1 RHNO1
3 cavernous sinus thrombosis 10.0 PGBD1 RHNO1
4 orbital cellulitis 9.9 PGBD1 RHNO1
5 acute orbital inflammation 9.8 PGBD1 RHNO1
6 lymphoma 9.7
7 histiocytosis 9.7
8 hyperthyroidism 9.7
9 herpes zoster 9.7
10 herpes zoster ophthalmicus 9.7
11 langerhans cell histiocytosis 9.6
12 mastitis 9.6
13 graves' disease 9.6
14 rhabdomyosarcoma 9.6
15 enophthalmos 9.2 EPB41L1 FAF2 TFAP2A TNNI3K

Graphical network of the top 20 diseases related to Orbital Disease:



Diseases related to Orbital Disease

Symptoms & Phenotypes for Orbital Disease

UMLS symptoms related to Orbital Disease:


visual disturbance, eye manifestations

GenomeRNAi Phenotypes related to Orbital Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.02 FAF2 KIDINS220 RHNO1 TSHR
2 Decreased homologous recombination repair frequency GR00236-A-2 9.02 RHNO1

Drugs & Therapeutics for Orbital Disease

Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
3
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
6
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
7
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7553-56-2 807
8
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
9
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3 51-84-3 187
10
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
11
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
13
Methimazole Approved Phase 4,Phase 1,Phase 2,Not Applicable 60-56-0 1349907
14
Bimatoprost Approved, Investigational Phase 4,Phase 3,Early Phase 1 155206-00-1 5311027
15
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
16
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1 1177-87-3
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
19
leucovorin Approved Phase 4,Not Applicable 58-05-9 6006 143
20
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
21
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
22
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
24
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable 2920-86-7
25 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
26 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Methylprednisolone Acetate Phase 4,Phase 2,Phase 3,Not Applicable
34 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
35 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
40 Antithyroid Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Not Applicable
42 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
43 cadexomer iodine Phase 4,Phase 3,Phase 2,Not Applicable
44 Nutrients Phase 4,Phase 3,Phase 2,Not Applicable
45 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
47 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
48 Immunosuppressive Agents Phase 4,Not Applicable
49 Triamcinolone hexacetonide Phase 4,Not Applicable
50 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 132)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
2 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
3 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
4 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
5 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
6 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
7 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
8 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
9 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
10 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
11 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
12 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
13 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
14 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
15 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
16 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
17 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
18 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
19 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
20 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
21 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
22 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
23 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
24 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
25 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
26 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
27 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
28 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
29 Surgical Idiopathic Intracranial Hypertension Treatment Trial Recruiting NCT03501966 Phase 3 Acetazolamide
30 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
31 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
32 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
33 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
34 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Active, not recruiting NCT03298867 Phase 3
35 Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study Enrolling by invitation NCT03461211 Phase 3
36 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
37 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
38 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
39 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
40 Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Unknown status NCT01119144 Phase 2
41 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
42 Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED) Completed NCT00954057 Phase 2 LIPO-102;Placebo
43 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
44 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
45 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533
46 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2 ATD Group
47 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
48 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
49 Teprotumumab (RV 001) Treatment in Patients With Active Thyroid Eye Disease Completed NCT01868997 Phase 2 teprotumumab;normal saline
50 Rituximab Treatment of Graves' Dysthyroid Ophthalmopathy Completed NCT00424151 Phase 1, Phase 2 Rituximab

Search NIH Clinical Center for Orbital Disease

Cochrane evidence based reviews: orbital diseases

Genetic Tests for Orbital Disease

Anatomical Context for Orbital Disease

MalaCards organs/tissues related to Orbital Disease:

42
Eye, Thyroid, Ciliary Ganglion, Liver, Bone, B Cells, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Disease:

20
The Eye Socket

Publications for Orbital Disease

Articles related to Orbital Disease:

(show top 50) (show all 118)
# Title Authors Year
1
The treatment outcomes in IgG4-related orbital disease: a systematic review of the literature. ( 30734497 )
2019
2
IgG4-related orbital disease. ( 29866378 )
2018
3
Diagnosis and Management of Pediatric Orbital Diseases. ( 29517648 )
2018
4
Treatment of Pediatric IgG4-Related Orbital Disease With TNF-I+ Inhibitor. ( 28700400 )
2017
5
IgG4-related orbital disease masquerading as thyroid eye disease, vice versa, or both? ( 29053038 )
2017
6
Incipient Ocular Mucosa-associated Lymphoid Tissue Lymphoma in IgG4-related Orbital Disease. ( 28367047 )
2017
7
Immunoglobulin G4-related orbital disease: An important differential diagnosis for orbital swellings with lymphoplasmacytic infiltration. ( 28937398 )
2017
8
Orbital Disease in Neuro-Ophthalmology. ( 27886890 )
2017
9
Infliximab for IgG4-Related Orbital Disease. ( 26784550 )
2016
10
IgG4 related orbital disease presenting with unilateral eyelid swelling. ( 27565007 )
2016
11
IgG4-related orbital disease mass lesion. ( 27085284 )
2016
12
Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease. ( 27116895 )
2016
13
A case of non-lacrimal immunoglobulin G4 (IgG4)-related orbital disease with mastitis. ( 26700191 )
2016
14
Radiologic-pathologic correlation of orbital diseases. ( 27029808 )
2016
15
IgG4-related Orbital Disease and Its Mimics in a Western Population. ( 26379149 )
2015
16
Langerhans cell histiocytosis with presentation as orbital disease. ( 26167225 )
2015
17
Immunoglobulin G4-related orbital disease: report of two pediatric cases. ( 25897575 )
2015
18
Imaging of Pediatric Orbital Diseases. ( 26208421 )
2015
19
Management of Orbital Diseases. ( 26494502 )
2015
20
Rituximab for the treatment of IgG4-related orbital disease: experience from five cases. ( 25341435 )
2014
21
Sequential biopsies from immunoglobulin G4-related orbital disease demonstrate progressive fibrosis. ( 24617918 )
2014
22
Kimura's disease of the lacrimal gland mimicking IgG4-related orbital disease. ( 25511019 )
2014
23
The meaning of diagnoses in orbital disease. ( 24022349 )
2013
24
Bilateral orbital and optic nerve endoscopic endonasal decompression for nonspecific inflammatory orbital disease: case report. ( 23042140 )
2013
25
Teaching neuroimages: IgG4-related orbital disease and enlargement of the trigeminal nerve branches. ( 24101754 )
2013
26
IgG4-related orbital disease: a meta-analysis and review. ( 22963447 )
2013
27
MAGNETIC RESONANCE IMAGING CONTRAST ENHANCEMENT OF EXTRA-OCULAR MUSCLES IN DOGS WITH NO CLINICAL EVIDENCE OF ORBITAL DISEASE. ( 23890158 )
2013
28
The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease. ( 22644450 )
2012
29
Addition of a minimally invasive medial orbital approach in the endoscopic management of advanced sino-orbital disease: cadaver study with clinical correlations. ( 21271602 )
2011
30
Neuro-ophthalmology of orbital disease. ( 21601077 )
2011
31
Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. ( 21242849 )
2011
32
Zolendronate associated inflammatory orbital disease. ( 20930911 )
2010
33
Spectrum of orbital disease in South India: an aravind study of 6328 consecutive patients. ( 20592641 )
2010
34
Image-guided transnasal endoscopic techniques in the management of orbital disease. ( 20807018 )
2010
35
Orbital disease in neuro-ophthalmology. ( 20637996 )
2010
36
Imaging for neuro-ophthalmic and orbital disease - a review. ( 19016810 )
2009
37
Intraocular pressure change in orbital disease. ( 19682621 )
2009
38
Application of tele-ophthalmology in remote diagnosis and management of adnexal and orbital diseases. ( 19700877 )
2009
39
Bilateral infiltrative orbital disease: is it chemically induced? ( 18982043 )
2008
40
Isolated upper eyelid retraction: a sign of idiopathic inflammatory orbital disease. ( 18209649 )
2008
41
Hyperthyroidism and severity of orbital disease do not change the central corneal thickness in Graves' ophthalmopathy. ( 18203097 )
2008
42
Severe, permanent orbital disease in herpes zoster ophthalmicus. ( 18716975 )
2008
43
Hyperthyroidism and severity of orbital disease do not change the central corneal thickness in Graves'' ophthalmopathy. ( 28221500 )
2008
44
Endoscopic sinus surgery for the management of orbital diseases. ( 18408413 )
2008
45
Assessment of ultrasonography and computed tomography for the evaluation of unilateral orbital disease in dogs. ( 17331049 )
2007
46
A personal view: probability in medicine, levels of (Un)certainty, and the diagnosis of orbital disease (with particular reference to orbital "pseudotumor"). ( 18071128 )
2007
47
Extraocular muscle quantification using mathematical morphology: a semi-automatic method for analyzing muscle enlargement in orbital diseases. ( 17081729 )
2007
48
Radiologic evaluation of lacrimal and orbital disease. ( 16982252 )
2006
49
Office evaluation of lacrimal and orbital disease. ( 16982254 )
2006
50
Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosis. ( 15774931 )
2005

Variations for Orbital Disease

Expression for Orbital Disease

Search GEO for disease gene expression data for Orbital Disease.

Pathways for Orbital Disease

GO Terms for Orbital Disease

Sources for Orbital Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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