Orbital Disease (ORBIT)

Categories: Bone diseases, Eye diseases, Muscle diseases
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Aliases & Classifications for Orbital Disease

Summaries for Orbital Disease

Disease Ontology: 11 An adnexa disease that is located in the eye socket.

MalaCards based summary: Orbital Disease, also known as orbit, is related to graves disease 1 and optic nerve disease, and has symptoms including visual disturbance and eye manifestations. An important gene associated with Orbital Disease is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Ciprofloxacin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include eye socket, eye and ciliary ganglion, and related phenotypes are immune system and hematopoietic system

Wikipedia: 75 In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are... more...

Related Diseases for Orbital Disease

Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 525)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 30.7 TSHR TG CRP
2 optic nerve disease 30.4 NF1 ERCC6 CRP CD4
3 hyperthyroidism 30.3 TSHR TG PRTN3 CRP
4 thyroiditis 30.0 TSHR TG CRP
5 igg4-related disease 30.0 PRTN3 MPO CRP CD4 CD1E CD1A
6 polyarteritis nodosa 30.0 PRTN3 MPO CRP
7 neurilemmoma 29.9 SYP NF1 CD34
8 orbital cellulitis 29.9 PRTN3 NCAM1 CRP CD4
9 kimura disease 29.9 CD1E CD1B CD1A
10 papilledema 29.9 SYP CRP CD4
11 endocrine exophthalmos 29.9 TSHR TG CD5
12 enophthalmos 29.8 NF1 FBN1 ERCC6
13 orbital plasma cell granuloma 29.8 TSHR TG PRTN3 CRP
14 scleritis 29.8 PRTN3 MPO CRP
15 vascular cancer 29.7 SYP CD68 CD34
16 sarcoidosis 1 29.6 PRTN3 CRP CD68 CD4
17 granulomatosis with polyangiitis 29.6 PRTN3 MPO CRP CD4 CD34
18 myoblastoma 29.5 SYP CD68
19 lymphoma, non-hodgkin, familial 29.3 NCAM1 MME CD5 CD4 CD34
20 myeloid sarcoma 29.2 NCAM1 MPO CD68 CD34
21 eye disease 29.1 TSHR NF1 FBN1 ERCC6 CRP CD68
22 meningioma, familial 28.8 SYP NF1 NCAM1 CD68 CD34 CD1E
23 langerhans cell histiocytosis 28.6 CD68 CD34 CD1E CD1D CD1C CD1B
24 histiocytosis-lymphadenopathy plus syndrome 28.6 CD68 CD1E CD1D CD1C CD1B CD1A
25 bicipital tenosynovitis 10.4 PRTN3 CRP
26 chronic lacrimal gland enlargement 10.4 PRTN3 CD34
27 acute serous otitis media 10.4 PRTN3 CD34
28 arteritic anterior ischemic optic neuropathy 10.4 PRTN3 CRP
29 liver inflammatory pseudotumor 10.4 CRP CD34
30 sclerosing keratitis 10.4 PRTN3 CRP
31 anterior scleritis 10.4 PRTN3 CRP
32 epithelioid neurofibroma 10.4 NF1 CD34
33 lateral medullary syndrome 10.4 PRTN3 CRP
34 palindromic rheumatism 10.4 PRTN3 CRP
35 deep keratitis 10.4 PRTN3 CRP
36 iodine hypothyroidism 10.4 TSHR TG
37 libman-sacks endocarditis 10.4 PRTN3 CRP
38 thyroid angiosarcoma 10.4 TG CD34
39 inflamed seborrheic keratosis 10.3 CD1E CD1A
40 plexiform schwannoma 10.3 NF1 CD34
41 neurilemmoma of the fifth cranial nerve 10.3 NF1 CD34
42 small intestine leiomyoma 10.3 NF1 CD34
43 trigeminal nerve neoplasm 10.3 NF1 CD34
44 thyroid sarcoma 10.3 TG CD34
45 ventilation pneumonitis 10.3 CRP CD4
46 syphilitic meningitis 10.3 CRP CD4
47 third ventricle chordoid glioma 10.3 CD4 CD34
48 wissler-fanconi syndrome 10.3 PRTN3 CD4
49 brain stem infarction 10.3 PRTN3 CRP
50 endobronchial leiomyoma 10.3 PRTN3 CD34

Graphical network of the top 20 diseases related to Orbital Disease:

Diseases related to Orbital Disease

Symptoms & Phenotypes for Orbital Disease

UMLS symptoms related to Orbital Disease:

visual disturbance; eye manifestations

MGI Mouse Phenotypes related to Orbital Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 CD1D CD34 CD4 CD5 CD68 CRP
2 hematopoietic system MP:0005397 9.4 CD1D CD34 CD4 CD5 CD68 ERCC6

Drugs & Therapeutics for Orbital Disease

Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1, 93107-08-5 2764
2 Anti-Bacterial Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Cytochrome P-450 Enzyme Inhibitors Phase 3
5 KHK4083 Phase 3
Rituximab Approved Phase 1, Phase 2 174722-31-7
7 Hormones Phase 2
8 Calcium, Dietary Phase 2
9 Antirheumatic Agents Phase 1, Phase 2
10 Immunologic Factors Phase 1, Phase 2
Calcium Nutraceutical Phase 2 7440-70-2 271
Nivolumab Approved Phase 1 946414-94-4
Methotrexate Approved Phase 1 1959-05-2, 59-05-2 4112 126941
14 Antineoplastic Agents, Immunological Phase 1
15 Immune Checkpoint Inhibitors Phase 1
Thrombin Approved, Investigational
17 Anesthetics
18 Antithrombins

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Obesity Reduction Black Intervention Trial (ORBIT) Unknown status NCT00859989 Phase 3
2 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Subjects With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension and Pharmacokinetic Substudy (ORBIT-3) Completed NCT01515007 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
3 A Two-year Multi-center Phase 3 Study to Investigate the Efficacy and Safety of Secukinumab in Adult Patients With Active, Moderate to Severe Thyroid Eye Disease (ORBIT), With a Randomized, Parallel-group, Double-blind, Placebo-controlled, 16-week Treatment Period, and a Follow-up/Retreatment Period Recruiting NCT04737330 Phase 3 Secukinumab;Placebo
4 A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED) Recruiting NCT05276063 Phase 2, Phase 3 Linsitinib;Placebo
5 A Phase 3, Open-label, 52-week Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab (AMG 451) in Adolescent Subjects Aged ≥ 12 to < 18 Years With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Orbit) Not yet recruiting NCT05633355 Phase 3 Rocatinlimab
6 Comparing the Reconstruction of the Orbit Fracture With a Poly Caprolactone / Tri-Calcium Phosphate ( PCL/TCP ) Implant vs. a Titanium Mesh Implant. Unknown status NCT01119144 Phase 2
7 A PhaseI/II Prospective, Randomized, Dose-Ranging Pilot Study of Rituximab in the Treatment of Refractory Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
8 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
9 Ultra Low Dose 4 Gy Orbital Radiation for Definitive Therapy of Indolent B Cell Lymphoma Active, not recruiting NCT02494700 Phase 2 Orbital Radiation
10 A Phase 1B Trial Nivolumab Consolidation Following Completion of High-Dose Methotrexate Containing Induction Chemotherapy in Older (≥ 65) Patients With Primary CNS Lymphoma Recruiting NCT04022980 Phase 1 Nivolumab
11 Postoperative Pain of General Anesthesia in Orbital Disease and Ocular Tumor Unknown status NCT02704715
12 Lymphoma in the Orbit Unknown status NCT01302912
13 Post-enucleation Socket Syndrome Study (PESSS): Part 1 - Three Dimensional Volumetric Assessment of Anophthalmic Sockets With the New Multi-detector Computed Tomographic Technology Completed NCT00347282
14 Atypical Intraorbital Dermoid and Epidermoid Cyst: A Single Institution Cross-sectional Retrospective Study Completed NCT05410431
15 Ocriplasmin Research to Better Inform Treatment (ORBIT) Completed NCT02079883
16 Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (Orbit-AF II) Completed NCT01701817
17 Pilot Trial of Radioimmunotherapy With Yttrium 90-Labeled (90Y) Zevalin for Low-Grade Follicular Non-Hodgkin's Lymphoma or MALT of the Orbit/Conjunctiva Completed NCT00387023 Rituximab;Zevalin
18 Web-based Intervention With Email Support to Improve Quality of Life in Late Stage Bipolar Disorder (ORBIT): Randomised Controlled Trial Completed NCT03197974
19 Increasing Physical Activity Among Breast Cancer Survivors: Use of the ORBIT Model to Refine and Test a Novel Approach to Exercise Promotion Based on Affect-regulation Completed NCT04903249
20 Pivotal Trial to Evaluate the Safety and Efficacy of the Diamondback 360°® Orbital Atherectomy System in Treating De Novo, Severely Calcified Coronary Lesions (ORBIT II) Completed NCT01092416
21 Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Completed NCT01165710
22 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Completed NCT03753893
23 Artificial Intelligence-Assisted Facial, Periocular, and Orbital Analysis and Surgical Planning Completed NCT04319055
24 Contribution of the Quantitative Analysis of the Ultrasound Exam With Doppler for the Etiological Diagnosis of Orbital Masses (PUCE) Recruiting NCT02678091
25 International, Multicenter, Prospective Registry to Collect Data on Orbital Fractures (OFx), Their Primary and Secondary Treatment and Outcome Recruiting NCT03887988
26 Outcomes Related to Body Composition in Teens and Adults With Cystic Fibrosis (ORBIT-CF) Recruiting NCT04002882
27 Dynamic Contrast Enhanced Magnetic Resonance Imaging for Non-Invasive Diagnostic Work-Up in Solid Tumors of the Eye and Orbit. Recruiting NCT01653080
28 Clinical Trial of the Fit Families Multicomponent Obesity Intervention for African American Adolescents and Their Caregivers: Next Step From the ORBIT Initiative Recruiting NCT04974554
29 Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition) Enrolling by invitation NCT04856410
30 Evaluation of the Efficiency for Orbital Reconstruction After Defect of Bone Substance by Three-dimensional Printed Patient Specific Porous Titanium Implant in Comparison With Autologous Bone Graft Not yet recruiting NCT03608280

Search NIH Clinical Center for Orbital Disease

Cochrane evidence based reviews: orbital diseases

Genetic Tests for Orbital Disease

Anatomical Context for Orbital Disease

Organs/tissues related to Orbital Disease:

FMA: Eye Socket
MalaCards : Eye, Ciliary Ganglion, Bone, Thyroid, Breast, Lung, Brain

Publications for Orbital Disease

Articles related to Orbital Disease:

(show top 50) (show all 561)
# Title Authors PMID Year
Ocular manifestations of ANCA-associated vasculitis. 62
36440847 2022
Erdheim-Chester disease: look it in the eye. An orbital magnetic resonance imaging study. 62
35484665 2022
DMs-MAFM+EfficientNet: a hybrid model for predicting dysthyroid optic neuropathy. 62
36129645 2022
Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review. 62
34798654 2022
Retrobulbar Amphotericin B Injection in Curbing the Progression of COVID Associated Rhino-orbital Cerebral Mucormycosis: A Retrospective Case Series. 62
36246726 2022
A Study of Otorhinolaryngological Diseases with Ophthalmic Complications: At a Tertiary Care Center. 62
36452530 2022
Repurposing Lenvatinib as A Potential Therapeutic Agent against Thyroid Eye Disease by Suppressing Adipogenesis in Orbital Adipose Tissues. 62
36355477 2022
IgG4-Related Disease: sight-threatening orbital disease, spectacular improvement after Rituximab therapy. 62
36269307 2022
Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis. 62
36295095 2022
Paediatric orbital lymphoma; a case series and review of the literature. 62
36171296 2022
Is mucormycosis the end? A comprehensive management of orbit in COVID associated rhino-orbital-cerebral mucormycosis: preserving the salvageable. 62
36053359 2022
Evaluation of extraocular muscles in patients with thyroid associated ophthalmopathy using apparent diffusion coefficient measured by magnetic resonance imaging before and after radiation therapy. 62
34338029 2022
[The importance of standardized periorbital steroid injections for thyroid-associated ophthalmopathy]. 62
36069084 2022
[Chinese guideline on the diagnosis and treatment of thyroid-associated ophthalmopathy (2022)]. 62
36069085 2022
Advances in magnetic resonance imaging of orbital disease. 62
34058140 2022
Clinical characteristics, diagnosis, and outcomes of orbital biopsies in a single Irish centre. 62
35994223 2022
Clinical characteristics and the treatment modalities of Graves' orbitopathy in a tertiary referral center in Turkey: changes over two decades. 62
36030455 2022
Evaluation of Orbital Lymphoproliferative and Inflammatory Disorders by Gene Expression Analysis. 62
35955742 2022
Outcomes of Transcutaneous Retrobulbar Amphotericin B in Rhino-Orbital-Cerebral Mucormycosis Among Patients Recovering From COVID-19: A Preliminary Experience. 62
36106303 2022
Tissue IgG2/IgG4 Ratio as an Additional Tool to Distinguish IgG4-Related Disease From Other Fibroinflammatory Disorders. 62
35652730 2022
Sinonasal Small Cell Carcinoma-Case Series of a Rare Malignancy. 62
33090899 2022
IgG4-related disease in pediatric patients: a single-center experience. 62
33978820 2022
Orbital Exenteration for Advanced Periocular Adnexal Malignancies: Curative Versus Palliative Surgical Intent. 62
35093991 2022
Transcutaneous retrobulbar injection of amphotericin B in rhino-orbital-cerebral mucormycosis: a review. 62
34720026 2022
IgG4-related orbital disease. 62
34174214 2022
Endonasal Endoscopic Approach for Minimally Invasive Orbital Decompression in Nonthyroid Proptosis-A Scoping Review. 62
35331947 2022
Lymphoma and inflammatory disorders presenting in the orbit- a comparison of characteristics from a 10-year series in a tertiary hospital. 62
33645420 2022
Treatment of orbital lymphatic malformation with oral sirolimus: a case report. 62
35544942 2022
Clinical, advanced imaging data and outcome of inflammatory and neoplastic orbital disease in 81 dogs and 16 cats in Australia (2010-2019). 62
34554639 2022
Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland. 62
33172316 2022
Conjunctival Infiltration in a Child as a Rare Manifestation of IgG4-Related Disease. 62
34050069 2022
Experience on rhino-orbital mucormycosis from a tertiary care hospital in the first wave of COVID-19: An Indian perspective. 62
35400798 2022
Pediatric Subcutaneous Panniculitis-like T-cell Lymphoma of the Orbit. 62
34652312 2022
Transcutaneous retrobulbar amphotericin-B (TRAMB) injection in orbital mucormycosis. 62
35361668 2022
Normative orbital measurements in an Australian cohort on computed tomography. 62
35232320 2022
Feline ophthalmomyiasis externa caused by Cuterebra larvae: four cases (2005-2020). 62
33988048 2022
Concomitant adult onset xanthogranuloma and IgG4-related orbital disease: a rare occurrence. 62
32847452 2022
Radiographic analysis of fatty infiltration of the extraocular muscles in thyroid eye disease. 62
32878536 2022
A fungal epidemic amidst a viral pandemic: Risk factors for development of COVID-19 associated rhino-orbital-cerebral mucormycosis in India. 62
35192435 2022
Cumulative Mortality and Factors Associated With Outcomes of Mucormycosis After COVID-19 at a Multispecialty Tertiary Care Center in India. 62
34882192 2022
Association of Age-adjusted Charlson Comorbidity Index With Orbital Fungal Disease Outcomes. 62
34085995 2022
Retrobulbar injection of amphotericin B using intravenous cannula for post-COVID-19 rhino-orbital mucormycosis. 62
34937263 2022
Reduction of Interhemispheric Homotopic Connectivity in Cognitive and Visual Information Processing Pathways in Patients With Thyroid-Associated Ophthalmopathy. 62
35865354 2022
Repurposing super saturated potassium iodide as an adjunctive treatment in mucormycosis: An exposition in a diabetic patient with rhino-orbital disease with cutaneous extension. 62
34708500 2022
Anaplastic Thyroid Carcinoma with Ocular Then Orbital Metastases. 62
35350232 2022
Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves' Ophthalmopathy by Targeting Orbital Fibroblasts. 62
35663306 2022
Changes of Volume Parameters in the Treatment of Graves Ophthalmopathy by Endoscopic Transethmoidal Decompression of the Orbital Inner Wall Combined with Fat Decompression. 62
36082172 2022
Immunoglobulin G4-related orbital disease in an 8-year-old girl. 62
35278255 2022
Noninvasive Machine Learning Screening Model for Dacryocystitis Based on Ocular Surface Indicators. 62
34267140 2022
Rhino-orbital mucormycosis following COVID-19 in previously non-diabetic, immunocompetent patients. 62
34338124 2021

Variations for Orbital Disease

Expression for Orbital Disease

Search GEO for disease gene expression data for Orbital Disease.

Pathways for Orbital Disease

GO Terms for Orbital Disease

Cellular components related to Orbital Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016021 10.47 CD1A CD1B CD1C CD1D CD1E CD34
2 membrane GO:0016020 10.47 CD1A CD1B CD1C CD1D CD1E CD34
3 extracellular space GO:0005615 10.4 TG PRTN3 MPO FBN1 CRP CD1E
4 cell surface GO:0009986 10.1 TSHR NCAM1 MME CD4 CD34 CD1D
5 plasma membrane GO:0005886 10.07 CD1A CD1C CD1D CD1E CD34 CD4
6 plasma membrane GO:0005887 10.07 CD1A CD1C CD1D CD1E CD34 CD4
7 endosome membrane GO:0010008 10.02 CD1A CD1B CD1C CD1D CD68
8 lysosome GO:0005764 9.93 CD1B CD1C CD1D CD1E CD34 CD68
9 external side of plasma membrane GO:0009897 9.58 NCAM1 CD5 CD4 CD34 CD1E CD1D

Biological processes related to Orbital Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.02 CD4 CD1E CD1D CD1C CD1B CD1A
2 positive regulation of T cell mediated cytotoxicity GO:0001916 9.85 CD1A CD1B CD1C CD1D CD1E
3 immune system process GO:0002376 9.8 CD4 CD1E CD1D CD1C CD1B CD1A
4 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.65 CD1E CD1D CD1C CD1B CD1A
5 T cell selection GO:0045058 9.56 CD4 CD1D
6 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.32 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Orbital Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.85 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.65 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.32 CD1E CD1D CD1C CD1B CD1A

Sources for Orbital Disease

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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