ORBIT
MCID: ORB013
MIFTS: 42

Orbital Disease (ORBIT)

Categories: Bone diseases, Eye diseases

Aliases & Classifications for Orbital Disease

Summaries for Orbital Disease

Disease Ontology : 12 An adnexa disease that is located in the eye socket.

MalaCards based summary : Orbital Disease, also known as orbital diseases, is related to igg4-related disease and optic nerve disease, and has symptoms including visual disturbance and eye manifestations. An important gene associated with Orbital Disease is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Atracurium and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include eye socket, eye and thyroid, and related phenotypes are cellular and growth/size/body region

Wikipedia : 74 In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are... more...

Related Diseases for Orbital Disease

Diseases related to Orbital Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 igg4-related disease 30.6 PRTN3 KNTC1 CRP
2 optic nerve disease 30.3 PES1 ERCC6 CRYAA CRP
3 orbital cancer 30.0 PRTN3 NF1 KNTC1
4 orbital cellulitis 29.7 RHNO1 KNTC1 CRYAA CRP
5 eye disease 29.7 TSHR MIR193A FBN1 ERCC6 CRYAA CRP
6 scleritis 29.5 TNFRSF1B PRTN3 CRP
7 hyperthyroidism 29.5 TSHR TG PRTN3 CRP
8 keratitis, hereditary 29.4 PHOX2A KIF21A CRYAA
9 granulomatosis with polyangiitis 29.3 TNFRSF1B PRTN3 CRP
10 exophthalmos 29.3 TSHR TG RHNO1 PRTN3 NF1 CRP
11 orbital plasma cell granuloma 29.1 TNFRSF1B RHNO1 PRTN3 KNTC1 CRP
12 ocular motility disease 28.2 RHNO1 PHOX2A PES1 NT5C3A KIF21A CRYAA
13 strabismus 27.8 TSHR PHOX2A PES1 NT5C3A NF1 KIF21A
14 enophthalmos 27.4 TFAP2A SLC39A13 PHOX2A PES1 NT5C3A FBN1
15 acute maxillary sinusitis 10.5 RHNO1 CRP
16 orbital granuloma 10.5 PRTN3 CRP
17 maxillary sinusitis 10.5 PRTN3 CRP
18 subdural empyema 10.5 RHNO1 CRP
19 excessive tearing 10.5 TSHR RHNO1
20 posterior scleritis 10.4 PRTN3 CRP
21 olecranon bursitis 10.4 PES1 CRP
22 bicipital tenosynovitis 10.4 PRTN3 CRP
23 granulomatous angiitis 10.4 PRTN3 CRP
24 mikulicz disease 10.4 KNTC1 CRP
25 cerebritis 10.4 RHNO1 CRP
26 branch retinal artery occlusion 10.4 CRYAA CRP
27 cholesterol embolism 10.4 PRTN3 CRP
28 calcific tendinitis 10.4 PES1 CRP
29 mediastinitis 10.4 RHNO1 CRP
30 cogan syndrome 10.4 PRTN3 CRP
31 otitis externa 10.3 RHNO1 CRP
32 hemopericardium 10.3 HEG1 FBN1
33 subacute bacterial endocarditis 10.3 PRTN3 CRP
34 external ear disease 10.3 RHNO1 CRP
35 ethmoid sinusitis 10.3 RHNO1 PRTN3 CRP
36 multiple cranial nerve palsy 10.3 RHNO1 PRTN3 CRP
37 glossopharyngeal nerve disease 10.3 RHNO1 PRTN3 CRP
38 multiple pterygium syndrome, escobar variant 10.3 PES1 ERCC6 CRYAA
39 splenic infarction 10.3 PRTN3 CRP
40 paranasal sinus disease 10.3 RHNO1 PRTN3 CRP
41 nose disease 10.3 RHNO1 PRTN3 CRP
42 lens disease 10.3 FBN1 ERCC6 CRYAA
43 rheumatoid arthritis interstitial lung disease 10.3 TNFRSF1B CRP
44 physical disorder 10.2 PES1 ERCC6 CRYAA
45 brittle cornea syndrome 2 10.2 SLC39A13 ERCC6 CRYAA
46 mastoiditis 10.2 PRTN3 CRP
47 tracheal stenosis 10.2 RHNO1 PRTN3 FBN1
48 ankylosing spondylitis 1 10.2 TNFRSF1B CRP
49 acute orbital inflammation 10.2 RHNO1 KNTC1 CRYAA CRP
50 marcus gunn phenomenon 10.2 PHOX2A KIF21A

Graphical network of the top 20 diseases related to Orbital Disease:



Diseases related to Orbital Disease

Symptoms & Phenotypes for Orbital Disease

UMLS symptoms related to Orbital Disease:


visual disturbance, eye manifestations

MGI Mouse Phenotypes related to Orbital Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 ERCC6 FBN1 HEG1 KIF21A NF1 PHOX2A
2 growth/size/body region MP:0005378 9.73 ERCC6 FBN1 HEG1 KIF21A NF1 PES1
3 craniofacial MP:0005382 9.7 FBN1 HEG1 NF1 PES1 SLC39A13 TFAP2A
4 limbs/digits/tail MP:0005371 9.17 ERCC6 FBN1 KNTC1 NF1 TFAP2A TG

Drugs & Therapeutics for Orbital Disease

Drugs for Orbital Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Adalimumab Approved Phase 4 331731-18-1 16219006
4
Etanercept Approved, Investigational Phase 4 185243-69-0
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
7
Promethazine Approved, Investigational Phase 4 60-87-7 4927
8
Zaleplon Approved, Illicit, Investigational Phase 4 151319-34-5 5719
9
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
10
Zolpidem Approved Phase 4 82626-48-0 5732
11
Budesonide Approved Phase 4 51333-22-3 63006 5281004
12
rituximab Approved Phase 4 174722-31-7 10201696
13
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
14
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
15
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
18
leucovorin Approved Phase 4 58-05-9 6006 143
19
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
22
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
23
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
24 Cholinergic Agents Phase 4
25 Anesthetics, General Phase 4
26 GABA Modulators Phase 4
27 Anesthetics, Intravenous Phase 4
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4
29 Neuromuscular Blocking Agents Phase 4
30 Cholinergic Antagonists Phase 4
31 Narcotics Phase 4
32 Analgesics, Opioid Phase 4
33 GABA Agonists Phase 4
34 Anticonvulsants Phase 4
35 Immunologic Factors Phase 4
36 Antirheumatic Agents Phase 4
37 Antineoplastic Agents, Immunological Phase 4
38 Gastrointestinal Agents Phase 4
39 Methylprednisolone Acetate Phase 4
40 Hormones Phase 4
41 glucocorticoids Phase 4
42 Antineoplastic Agents, Hormonal Phase 4
43 Hormone Antagonists Phase 4
44 Neuroprotective Agents Phase 4
45 Antiemetics Phase 4
46 Anti-Inflammatory Agents Phase 4
47 Immunoglobulins Phase 4
48 Antibodies Phase 4
49 Immunosuppressive Agents Phase 4
50 Immunoglobulins, Intravenous Phase 4

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
2 Evaluating the Safety and Efficacy of Polyglycolic Acid Suture in Ophthalmic Surgical Procedures Completed NCT00351429 Phase 4
3 Impact of Transcranial Direct Current Stimulation (tDCS) on Locomotion and Bipedal Equilibrium in Hemiplegic Patients: a Crossover Randomized Controlled Trial Completed NCT02134158 Phase 4
4 Optimal Management of Rheumatoid Arthritis Patients Requiring Biologic Therapy Completed NCT01021735 Phase 4 etanercept or adalimumab;Rituximab
5 Efficacy and Safety of Low Dose Atracurium Added to Lidocaine, Bupivacaine and Hyaluronidase Mixture in Percaruncular Peribulbar Anesthesia for High Myopes Undergoing Phacoemulsification: A Randomized Controlled Trial. Completed NCT03243500 Phase 4 Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
6 Nalbuphine, Fentanyl and no Additive to Local Anaesthetic Mixture for Peribulbar Block During Posterior Segment Surgery in Adult Patients a Prospective Randomized Clinical Trial Completed NCT03824665 Phase 4 Nalbuphine Group;Fentanyl Group;Control Group
7 A Randomised Controlled Trial to Compare Success and Complication Rates in Endonasal Dacryocystorhinostomy Surgery With and Without Silicone Tubes Completed NCT00784992 Phase 4
8 Operational Ground Testing Protocol to Optimize Astronaut Sleep Medication Efficacy and Individual Effects Completed NCT03526575 Phase 4 Zolpidem
9 The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device: A Randomized, Single-blind, Parallel Trial Comparing the Lying-Head-Back Versus the Head-Down-to-Floor Positions Completed NCT02079792 Phase 4
10 Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
11 Comparison Between Dexmedetomidine and Lidocaine as an Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries Not yet recruiting NCT03600493 Phase 4 Dexmedetomidine;Lidocaine
12 Obesity Reduction Black Intervention Trial (ORBIT) Unknown status NCT00859989 Phase 3
13 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Subjects With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension and Pharmacokinetic Substudy (ORBIT-3) Completed NCT01515007 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
14 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Patients With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension Completed NCT02104245 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
15 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Completed NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
16 Actinomycin D and Vincristine With or Without Radiation Therapy, for Newly Diagnosed Patients With Low-Risk Rhabdomyosarcoma or Undifferentiated Sarcoma: IRS-V Protocol Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
17 Clinical Trial Phase III, Parallel Group, Randomized, Placebo-controlled, Double-blind, Multicenter Study to Evaluate the Efficacy and Safety of Tocilizumab Administration in Patients With Moderate-to-severe or Sight-threatening Graves' Ophthalmopathy (GO), That Had Not Responded Adequately to Treatment With Intravenous Corticoid Pulses. Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
18 A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS) Recruiting NCT02567435 Phase 3 Cyclophosphamide;Irinotecan Hydrochloride;Temsirolimus;Vincristine Sulfate;Vinorelbine
19 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
20 Attenuation Corrected Cardiac SPECT Using the GE Hawkeye Camera System Terminated NCT00587730 Phase 2, Phase 3
21 Comparing the Reconstruction of the Orbit Fracture With a Poly Caprolactone / Tri-Calcium Phosphate ( PCL/TCP ) Implant vs. a Titanium Mesh Implant. Unknown status NCT01119144 Phase 2
22 A Pilot Study Using an NMDA Antagonist to Modulate Transcranial Direct Current Stimulation (tDCS) Effects on Auditory Sensory Memory Processing Unknown status NCT02426983 Phase 1, Phase 2 Dextromethorphan
23 A Prospective Single Arm Trial of Involved Field Radiotherapy Alone for Stage I-II Low Grade Non-gastric Marginal Zone Lymphoma Unknown status NCT00377195 Phase 2
24 A PhaseI/II Prospective, Randomized, Dose-Ranging Pilot Study of Rituximab in the Treatment of Refractory Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
25 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
26 Effects of Clonidine Added to Lidocaine in Sub-Tenon's and Peribulbar Anesthesia: Assessments of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP) and Ocular Pulse Amplitude (OPA) Completed NCT02733757 Phase 2 Clonidine
27 Effects of Transcranial Direct Current Stimulation Associated With Physical Therapy on Motor Rehabilitation in Parkinson´s Disease Patients Completed NCT01877148 Phase 2
28 Placebo Controlled Study of the Therapeutic Effect of the Transcranial Electrical Polarization in Patients With Focal Hand Dystonia Completed NCT00106782 Phase 2
29 Impact of Transcranial Direct Current Stimulation (tDCS)on the Effects of Mental Practice and Modified Constraint-induced Movement Therapy (mCIMT)in the Rehabilitation of Chronic Stroke Patients Completed NCT01879787 Phase 2
30 A Phase II Study of Concurrent Chemoradiation for The Localized Nasal NK/T-cell Lymphoma Completed NCT00292695 Phase 2
31 B Cell Depletion With the Anti-CD20 Monoclonal Antibody Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
32 A Phase 2 Trial of the MEK Inhibitor PD-0325901 in Adolescents and Adults With NF1-Associated Morbid Plexiform Neurofibromas Completed NCT02096471 Phase 2 PD-0325901
33 Enhancing Developmental Motor Plasticity After Perinatal Stroke With Transcranial Direct Current Stimulation Completed NCT02170285 Phase 2
34 Ultra Low Dose 4 Gy Orbital Radiation for Definitive Therapy of Indolent B Cell Lymphoma Recruiting NCT02494700 Phase 2 Orbital Radiation
35 Ipilimumab and Nivolumab in Combination With Immunoembolization for the Treatment of Metastatic Uveal Melanoma Recruiting NCT03472586 Phase 2 Embolization Therapy
36 Beat!: A Randomized Controlled Clinical Trial Recruiting NCT03958331 Phase 2
37 An Open Label Trial of Celecoxib in the Treatment of Mild Thyroid Eye Disease Recruiting NCT02845336 Phase 2 Celecoxib;artificial tears
38 Phase II Randomized Trial of Neo-Adjuvant Chemotherapy Followed by Surgery and Post-Operative Radiation Versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC) Recruiting NCT03493425 Phase 2 Carboplatin;Cisplatin;Docetaxel
39 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
40 Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala Terminated NCT01857752 Phase 2 Temozolomide
41 Interventions to Decrease the Impact of Post-Operative Ileus After Liver Transplant or Resection Surgery Completed NCT01156129 Phase 1 stool softener
42 Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using Intratumoral Delivery of Non-coherent Light for Photoactivation of LS11 in Children With Plexiform Neurofibromas Terminated NCT00716469 Phase 1 LS11
43 Postoperative Pain of General Anesthesia in Orbital Disease and Ocular Tumor Unknown status NCT02704715
44 Effectiveness and Possible Complications of Core Needle Biopsy of Orbital Tumors Unknown status NCT01772355
45 Orbital Fractures Measurement: Intraoperative Versus Computed Tomography (CT) Scan Unknown status NCT01464541
46 Pilot Clinical Trial on a New Adjustable Glaucoma Drainage Device Unknown status NCT02554214
47 Lymphoma in the Orbit Unknown status NCT01302912
48 Pascal Dynamic Contour Tonometer Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on Orbital CT Scan Unknown status NCT00646295
49 Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's Orbitopathy Unknown status NCT01999790
50 A Comparison Between Scalp Nerve Block and Scalp Infiltration on the Circulatory and Stress Response for Aneurysm Clipping Using an Enhanced Recovery After Surgery Programme Unknown status NCT03073889 Ropivacaine

Search NIH Clinical Center for Orbital Disease

Cochrane evidence based reviews: orbital diseases

Genetic Tests for Orbital Disease

Anatomical Context for Orbital Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Orbital Disease:

19
Eye Socket

MalaCards organs/tissues related to Orbital Disease:

40
Eye, Thyroid, Ciliary Ganglion, Testes, Bone, Lung, B Cells

Publications for Orbital Disease

Articles related to Orbital Disease:

(show top 50) (show all 662)
# Title Authors PMID Year
1
Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease. 61
32501880 2020
2
Carcinoid Tumors of the Orbit and Ocular Adnexa. 61
32496392 2020
3
T2 mapping of the extraocular muscles in healthy volunteers: preliminary research on scan-rescan and observer-observer reproducibility. 61
31581780 2020
4
Normative Exophthalmometry Measurements Vary Among Ethiopian Adults and the Major Ethiopian Ethnic Groups. 61
32467519 2020
5
Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review. 61
32427727 2020
6
Radiation-Induced Hyalinizing Clear Cell Carcinoma of the Orbit. 61
32427738 2020
7
IgG4-related disease: a clinical perspective. 61
32348524 2020
8
Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis. 61
32358156 2020
9
Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis. 61
31691261 2020
10
Sarcoid-like granulomatous orbitopathy-presentation, systemic involvement and clinical outcome. 61
32317795 2020
11
The expanded endonasal approach in pediatric skull base surgery: A review. 61
32337363 2020
12
Subtotal Exenteration of the Orbit for Benign Orbital Disease. 61
32224777 2020
13
The role of ultrasonography in differential diagnosis of orbital lesions. 61
32166724 2020
14
Prostaglandin analogues: A double-edged sword in orbital glaucoma disease management. 61
32043370 2020
15
[Use of the Multidisciplinary Specialised Case Conference at the Freiburg Orbital Centre]. 61
32016941 2020
16
Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases. 61
32083541 2020
17
A Comparative Study of Clinical vs. Digital Exophthalmometry Measurement Methods. 61
32280513 2020
18
An accurate interactive segmentation and volume calculation of orbital soft tissue for orbital reconstruction after enucleation. 61
31842802 2019
19
Clinical and histopathological findings of patients with orbital granulomatosis with polyangiitis cases refractory to rituximab. 61
31836100 2019
20
Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT. 61
31867079 2019
21
Post-traumatic enophthalmos secondary to orbital fat atrophy: a volumetric analysis. 61
31726012 2019
22
[Orbital Disorders in Childhood]. 61
31412385 2019
23
[Actively promoting the research and development of artificial intelligence diagnosis and treatment of orbital disease]. 61
31715675 2019
24
Compressive optic neuropathy with vision loss due to IgG4-related orbital disease. 61
31590594 2019
25
Applications of three-dimensional printing in orbital diseases and disorders. 61
31261186 2019
26
Primary orbital tuberculosis on the lower eyelid with cold abscess. 61
31462022 2019
27
The treatment outcomes in IgG4-related orbital disease: a systematic review of the literature. 61
30734497 2019
28
Aminobisphosphonate-associated orbital and ocular inflammatory disease. 61
30816018 2019
29
Successful treatment of tubulointerstitial nephritis in immunoglobulin G4-related disease with rituximab: A case report. 61
31531324 2019
30
An unusual cause of bilateral orbital swelling: Immunoglobulin G4-related orbital disease arising in a patient with ulcerative colitis. 61
31341945 2019
31
Research on the Potential Mechanism of Gypenosides on Treating Thyroid-Associated Ophthalmopathy Based on Network Pharmacology. 61
31268042 2019
32
Invasive sino-orbital fungal infections in immunocompetent patients: a clinico-pathological study. 61
30765886 2019
33
Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease. 61
31215395 2019
34
Ocular involvement in granulomatosis with polyangiitis: A single-center cohort study on 63 patients. 61
30844550 2019
35
Computed tomography imaging-based normative orbital measurement in Indian population. 61
31007233 2019
36
Chemoreduction of Orbital Recurrence of Uveal Melanoma by Intra-Arterial Melphalan. 61
31049326 2019
37
Knowledge of Thyroid Eye Disease in Graves' Disease Patients With and Without Orbitopathy. 61
30688164 2019
38
IgG4-related disease: what a hematologist needs to know. 61
30705099 2019
39
Distinguishing IgG4-Related Ophthalmic Disease From Graves Orbitopathy. 61
30124607 2019
40
The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy. 61
30531993 2019
41
Management of IgG4-related orbital disease: when not in doubt, cut it out? 61
31750397 2019
42
[Clinical features of malignant orbital lymphoma]. 61
31714507 2019
43
[Orbital Manifestation of IgG4-Related Disease: Three Case Reports]. 61
30690697 2019
44
Clinical observation of orbital IgG4-related diseases. 61
30651876 2019
45
Measurement of the Orbital Soft Tissue Volume in Chinese Adults Based on Three-Dimensional CT Reconstruction. 61
31341660 2019
46
Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography. 61
31456921 2019
47
The eye of the beholder: orbital metastases from midgut neuroendocrine tumors, a two institution experience. 61
30522522 2018
48
A Case of Radioactivity Concentrated in Orbital Implant in 99mTc-MDP Bone Scan and SPECT/CT. 61
30247211 2018
49
[Possible surgical approaches to the orbit]. 61
30306197 2018
50
IgG4-related orbital disease. 61
29866378 2018

Variations for Orbital Disease

Expression for Orbital Disease

Search GEO for disease gene expression data for Orbital Disease.

Pathways for Orbital Disease

Pathways related to Orbital Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.4 TSHR TG

GO Terms for Orbital Disease

Biological processes related to Orbital Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sympathetic nervous system development GO:0048485 8.96 PHOX2A NF1
2 oculomotor nerve formation GO:0021623 8.62 TFAP2A PHOX2A

Sources for Orbital Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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