Orbital Granuloma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Orbital Granuloma

MalaCards integrated aliases for Orbital Granuloma:

Name: Orbital Granuloma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10499

ICD9CM ³⁴ 376.11

NCIt ⁵⁰ C3653

SNOMED-CT ⁶⁷ 194008000

ICD10 ³² H05.11

UMLS ⁷⁰ C0155262

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Summaries for Orbital Granuloma

MalaCards based summary : Orbital Granuloma is related to cat-scratch disease and granulomatosis with polyangiitis. An important gene associated with Orbital Granuloma is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Innate Immune System. Affiliated tissues include lung, heart and lymph node, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Orbital Granuloma

Diseases related to Orbital Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)

#	Related Disease	Score	Top Affiliating Genes
1	cat-scratch disease	30.1	CRP ACE
2	granulomatosis with polyangiitis	29.9	PRTN3 MPO CRP CD34
3	allergic cutaneous vasculitis	10.4	PRTN3 MPO
4	frontal sinusitis	10.4	PRTN3 CRP
5	orbital plasma cell granuloma	10.4	PRTN3 CRP
6	bicipital tenosynovitis	10.4	PRTN3 CRP
7	tenosynovitis	10.4	PRTN3 CRP
8	ethmoid sinusitis	10.4	PRTN3 CRP
9	acute dacryoadenitis	10.4	CRP ACE
10	acute frontal sinusitis	10.4	PRTN3 MPO
11	mediastinum teratoma	10.4	CRP ACE
12	anca-associated vasculitis	10.4	PRTN3 MPO
13	cardiac tuberculosis	10.4	CRP ACE
14	skeletal tuberculosis	10.4	ESX1 CRP
15	rheumatoid arthritis interstitial lung disease	10.4	MUC1 CRP
16	mediastinitis	10.4	MPO CRP
17	lipid pneumonia	10.4	MUC1 CRP
18	chronic maxillary sinusitis	10.4	PRTN3 MPO
19	breast abscess	10.4	MUC1 CRP
20	silent myocardial infarction	10.4	CRP ACE
21	urinary tract infection	10.4	CRP ACE
22	neuroretinitis	10.4	CRP ACE
23	pulmonary hemosiderosis	10.4	PRTN3 MPO
24	ankylosing spondylitis 3	10.4	FCGRT CRP
25	purulent acute otitis media	10.4	PRTN3 MPO CRP
26	optic papillitis	10.4	CRP ACE
27	scleritis	10.3	PRTN3 MPO CRP
28	b-cell non-hodgkin lymphoma	10.3	TNFSF13B LCP1
29	subacute bacterial endocarditis	10.3	PRTN3 MPO CRP
30	mastoiditis	10.3	PRTN3 MPO CRP
31	aortitis	10.3	PRTN3 MPO CRP
32	lymph node tuberculosis	10.3	LTA4H CRP
33	chondromalacia	10.3	PRTN3 MPO CRP
34	maxillary sinusitis	10.3	PRTN3 MPO CRP
35	autoimmune vasculitis	10.3	PRTN3 MPO CRP
36	acute proliferative glomerulonephritis	10.3	PRTN3 MPO CRP
37	ecthyma	10.3	CSF3 CRP
38	cholangitis	10.3	PRTN3 MPO CRP
39	rapidly progressive glomerulonephritis	10.3	PRTN3 MPO CRP
40	marginal corneal ulcer	10.3	MPO CRP
41	cranial nerve palsy	10.3	PRTN3 CRP ACE
42	splenic tuberculosis	10.3	PRTN3 CRP
43	pyomyositis	10.3	CSF3 CRP
44	mikulicz disease	10.3	TNFSF13B CRP
45	splenic abscess	10.3	CSF3 CRP
46	middle ear disease	10.3	PRTN3 MPO CRP
47	acute interstitial pneumonia	10.3	MUC1 CRP
48	anterior scleritis	10.3	PRTN3 CRP ACE
49	posterior scleritis	10.3	PRTN3 CRP ACE
50	tolosa-hunt syndrome	10.3	PRTN3 CRP ACE

Graphical network of the top 20 diseases related to Orbital Granuloma:

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Symptoms & Phenotypes for Orbital Granuloma

MGI Mouse Phenotypes related to Orbital Granuloma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.86	ACE ADAMTS13 CD22 CD34 CSF3 FCGR2B
2	immune system	MP:0005387	9.58	ACE ADAMTS13 CD22 CD34 CRP CSF3

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Drugs & Therapeutics for Orbital Granuloma

Search Clinical Trials , NIH Clinical Center for Orbital Granuloma

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Genetic Tests for Orbital Granuloma

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Anatomical Context for Orbital Granuloma

MalaCards organs/tissues related to Orbital Granuloma:

⁴⁰

Lung, Heart, Lymph Node, Liver, Salivary Gland, Breast

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Publications for Orbital Granuloma

Articles related to Orbital Granuloma:

(show all 24)

#	Title	Authors	PMID	Year
1	Orbital granuloma formation following autoinjection of paraffin oil: management considerations. ⁶¹	Cadmus SD...Vrcek I	33186437	2020
2	Massive Silicone-Induced Orbital Granuloma. ⁶¹	Shue A...Minckler DS	32258023	2020
3	[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement]. ⁶¹	Panova IE...Samkovich EV	30499537	2018
4	A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. ⁶¹	Chen VH...Kim HJ	27281484	2017
5	Orbital granuloma: a rare manifestation of extrapulmonary tuberculosis. ⁶¹	Benech N...Ferry T	26933187	2016
6	Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases. ⁶¹	Bitik B...Goker B	25413843	2015
7	Sarcoidosis in the national veteran population: association of ocular inflammation and mortality. ⁶¹	Birnbaum AD...Wehrli S	25687027	2015
8	Orbital granuloma annulare as presentation of systemic sarcoidosis. ⁶¹	Kang JJ...Setabutr P	23895369	2013
9	Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. ⁶¹	Holle JU...Gross WL	22021864	2012
10	Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis. ⁶¹	Yalcindag FN...Forrester JV	18321200	2008
11	[Successful treatment with rituximab in a refractory Wegener's granulomatosis with hypertrophic pachymeningitis and the right orbital granuloma]. ⁶¹	Matsudaira R...Takasaki Y	17682433	2007
12	[Successful treatment of a patient with refractory Wegener's granulomatosis by rituximab]. ⁶¹	Minami R...Suematsu E	17473516	2007
13	A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease. ⁶¹	Tsukamoto H...Harada M	16126798	2006
14	Clinical images: orbital granuloma and subglottic tracheal stenosis in Wegener's granulomatosis. ⁶¹	Lamprecht P...Reuter M	10902772	2000
15	Application of polymerase chain reaction assay in the diagnosis of orbital granuloma complicating atypical oculoglandular cat scratch disease. ⁶¹	Dondey JC...Gatto J	9224472	1997
16	Indirect immunofluorescence study of the cornea and the conjunctiva in a xenogeneic system: analysis of humoral reactivity in patients with Wegener's granulomatosis. ⁶¹	Przyklang U...Duncker G	8720676	1996
17	Experimental immunogenic granuloma of the orbit: transfer of granulomatous hypersensitivity with a subset of T lymphocytes. ⁶¹	Liu SH...Silverstein AM	3484474	1986
18	Orbital granuloma in Hodgkin's disease. ⁶¹	Kielar RA	7316345	1981
19	Mycobacterium chelonei and orbital granuloma after tear duct probing. ⁶¹	Smith RE...Lewis W	7356779	1980
20	Orbital granuloma projecting through the upper fornix with a retained foreign body (record of an unusual case). ⁶¹	Sen DK	4637963	1972
21	Occlusion of the retinal artery in two cases of orbital granuloma. ⁶¹	Godfrey RC	5347174	1969
22	Extensive intracranial lesions in a case of orbital non-specific granuloma combined with polyarteritis nodosa. ⁶¹	ASTROM KE...LIDHOLM SO	13965307	1963
23	Bilateral orbital granuloma simulating a neoplasm. ⁶¹	HOGAN MJ...DICKSON OC	15424922	1950
24	[Progressive scleroperikeratitis with postenucleatory orbital granuloma]. ⁶¹	VOSS HJ	24539166	1950

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Genes for Orbital Granuloma

Genes related to Orbital Granuloma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PRTN3	Proteinase 3	Protein Coding	6.27	DISEASES inferred ¹⁵
2	CRP	C-Reactive Protein	Protein Coding	4.56	DISEASES inferred ¹⁵
3	LCP1	Lymphocyte Cytosolic Protein 1	Protein Coding	4.54	DISEASES inferred ¹⁵
4	MPO	Myeloperoxidase	Protein Coding	4.47	DISEASES inferred ¹⁵
5	LTA4H	Leukotriene A4 Hydrolase	Protein Coding	4.4	DISEASES inferred ¹⁵
6	ESX1	ESX Homeobox 1	Protein Coding	4.28	DISEASES inferred ¹⁵
7	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	4.2	DISEASES inferred ¹⁵
8	ACE	Angiotensin I Converting Enzyme	Protein Coding	4.05	DISEASES inferred ¹⁵
9	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	4.03	DISEASES inferred ¹⁵
10	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	3.88	DISEASES inferred ¹⁵
11	FCGRT	Fc Fragment Of IgG Receptor And Transporter	Protein Coding	3.88	DISEASES inferred ¹⁵
12	CSF3	Colony Stimulating Factor 3	Protein Coding	3.88	DISEASES inferred ¹⁵
13	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	3.87	DISEASES inferred ¹⁵
14	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	3.83	DISEASES inferred ¹⁵
15	CD34	CD34 Molecule	Protein Coding	3.59	DISEASES inferred ¹⁵
16	ADAMTS13	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13	Protein Coding	3.43	DISEASES inferred ¹⁵
17	TRIM21	Tripartite Motif Containing 21	Protein Coding	3.43	DISEASES inferred ¹⁵
18	CD22	CD22 Molecule	Protein Coding	3.33	DISEASES inferred ¹⁵
19	FCGR2B	Fc Fragment Of IgG Receptor IIb	Protein Coding	3.33	DISEASES inferred ¹⁵
20	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	3.29	DISEASES inferred ¹⁵

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Variations for Orbital Granuloma

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Expression for Orbital Granuloma

Search GEO for disease gene expression data for Orbital Granuloma.

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Pathways for Orbital Granuloma

Pathways related to Orbital Granuloma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.06	TRIM21 TNFSF13B TNFRSF25 TNFRSF13B PRTN3 MUC1
2	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.03	TRIM21 TNFSF13B TNFRSF25 TNFRSF13B PRTN3 MUC1
3	NF-kappaB Signaling ⁴	12.07	TNFSF13B TNFRSF25 MPO LCP1 CD34
4	Hematopoietic cell lineage ³⁶	11.63	CSF3 CD34 CD22
5	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.52	TNFSF13B TNFRSF25 TNFRSF13B
6	C-MYB transcription factor network ¹	11.44	PRTN3 MPO CD34
7	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.36	TNFSF13B TNFRSF25 TNFRSF13B
8	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.32	MPO CSF3 CD34 CD22
9	IgA-Producing B Cells in the Intestine ⁶⁴	11.25	TNFSF13B TNFRSF13B FCGR2B

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GO Terms for Orbital Granuloma

Cellular components related to Orbital Granuloma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	TNFSF13B TNFRSF25 PRTN3 MUC1 MPO LTA4H
2	external side of plasma membrane	GO:0009897	9.55	FCGRT FCGR2B CD34 CD22 ACE
3	extracellular space	GO:0005615	9.32	TNFSF13B PRTN3 MUC1 MPO LCP1 FCGRT

Biological processes related to Orbital Granuloma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of immune response	GO:0050776	9.46	TNFSF13B FCGR2B CD34 CD22
2	positive regulation of protein binding	GO:0032092	9.43	TRIM21 CSF3 ACE
3	negative regulation of immunoglobulin production	GO:0002638	9.32	FCGR2B CD22
4	negative regulation of B cell receptor signaling pathway	GO:0050859	8.96	FCGR2B CD22
5	peptide catabolic process	GO:0043171	8.8	LTA4H ADAMTS13 ACE

Molecular functions related to Orbital Granuloma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.93	TRIM21 TNFSF13B TNFRSF25 TNFRSF13B SSB SLC7A11
2	IgG binding	GO:0019864	8.62	FCGRT FCGR2B

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Sources for Orbital Granuloma

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