MCID: ORB010
MIFTS: 19

Orbital Granuloma

Categories: Bone diseases

Aliases & Classifications for Orbital Granuloma

MalaCards integrated aliases for Orbital Granuloma:

Name: Orbital Granuloma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10499
ICD9CM 34 376.11
NCIt 49 C3653
SNOMED-CT 67 72776003
ICD10 32 H05.11
UMLS 71 C0155262

Summaries for Orbital Granuloma

MalaCards based summary : Orbital Granuloma is related to exophthalmos and granulomatosis with polyangiitis. An important gene associated with Orbital Granuloma is PRTN3 (Proteinase 3), and among its related pathways/superpathways is C-MYB transcription factor network. Affiliated tissues include bone.

Related Diseases for Orbital Granuloma

Diseases related to Orbital Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.1 PRTN3 CRP
2 granulomatosis with polyangiitis 29.0 PRTN3 MPO CRP
3 cranial nerve palsy 10.2 PRTN3 CRP
4 anterior scleritis 10.2 PRTN3 CRP
5 scleritis 10.2 PRTN3 CRP
6 ethmoid sinusitis 10.2 PRTN3 CRP
7 posterior scleritis 10.2 PRTN3 CRP
8 tolosa-hunt syndrome 10.2 PRTN3 CRP
9 orbital plasma cell granuloma 10.2 PRTN3 CRP
10 bicipital tenosynovitis 10.2 PRTN3 CRP
11 tenosynovitis 10.2 PRTN3 CRP
12 synovitis 10.2 PRTN3 CRP
13 chronic orbital inflammation 10.2 PRTN3 CRP
14 granulomatous angiitis 10.2 PRTN3 CRP
15 glossopharyngeal nerve disease 10.2 PRTN3 CRP
16 cholesterol embolism 10.2 PRTN3 CRP
17 cogan syndrome 10.2 PRTN3 CRP
18 splenic infarction 10.2 PRTN3 CRP
19 pyuria 10.2 PRTN3 CRP
20 central retinal artery occlusion 10.2 PRTN3 CRP
21 lung abscess 10.2 PRTN3 CRP
22 cryptogenic organizing pneumonia 10.2 PRTN3 CRP
23 orbital disease 10.2 PRTN3 CRP
24 tracheal disease 10.2 PRTN3 CRP
25 tendinitis 10.1 PRTN3 CRP
26 facial nerve disease 10.1 PRTN3 CRP
27 facial paralysis 10.1 PRTN3 CRP
28 igg4-related disease 10.1 PRTN3 CRP
29 plasma protein metabolism disease 10.1 PRTN3 CRP
30 autoimmune disease of cardiovascular system 10.1 PRTN3 CRP
31 autoimmune disease of exocrine system 10.1 PRTN3 CRP
32 endocardium disease 10.1 PRTN3 CRP
33 skeletal tuberculosis 10.1 ESX1 CRP
34 syphilis 10.1 PRTN3 CRP
35 hypersensitivity reaction type iv disease 10.1 PRTN3 CRP
36 nose disease 10.1 PRTN3 CRP
37 limited scleroderma 10.1 PRTN3 CRP
38 lymphoid interstitial pneumonia 10.0 PRTN3 CRP
39 spondyloarthropathy 1 10.0 PRTN3 CRP
40 autoimmune disease of musculoskeletal system 10.0 PRTN3 CRP
41 purulent acute otitis media 9.9 PRTN3 MPO
42 allergic cutaneous vasculitis 9.9 PRTN3 MPO
43 anca-associated vasculitis 9.9 PRTN3 MPO
44 pulmonary hemosiderosis 9.9 PRTN3 MPO
45 anti-basement membrane glomerulonephritis 9.9 PRTN3 MPO
46 autoimmune disease of urogenital tract 9.9 PRTN3 MPO
47 mediastinitis 9.9 MPO CRP
48 marginal corneal ulcer 9.9 MPO CRP
49 goodpasture syndrome 9.9 PRTN3 MPO
50 neutrophilia, hereditary 9.8 MPO CRP

Graphical network of the top 20 diseases related to Orbital Granuloma:



Diseases related to Orbital Granuloma

Symptoms & Phenotypes for Orbital Granuloma

Drugs & Therapeutics for Orbital Granuloma

Search Clinical Trials , NIH Clinical Center for Orbital Granuloma

Genetic Tests for Orbital Granuloma

Anatomical Context for Orbital Granuloma

MalaCards organs/tissues related to Orbital Granuloma:

40
Bone

Publications for Orbital Granuloma

Articles related to Orbital Granuloma:

(show all 23)
# Title Authors PMID Year
1
Massive Silicone-Induced Orbital Granuloma. 61
32258023 2020
2
[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement]. 61
30499537 2018
3
A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. 61
27281484 2017
4
Orbital granuloma: a rare manifestation of extrapulmonary tuberculosis. 61
26933187 2016
5
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases. 61
25413843 2015
6
Sarcoidosis in the national veteran population: association of ocular inflammation and mortality. 61
25687027 2015
7
Orbital granuloma annulare as presentation of systemic sarcoidosis. 61
23895369 2013
8
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. 61
22021864 2012
9
Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis. 61
18321200 2008
10
[Successful treatment with rituximab in a refractory Wegener's granulomatosis with hypertrophic pachymeningitis and the right orbital granuloma]. 61
17682433 2007
11
[Successful treatment of a patient with refractory Wegener's granulomatosis by rituximab]. 61
17473516 2007
12
A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease. 61
16126798 2006
13
Clinical images: orbital granuloma and subglottic tracheal stenosis in Wegener's granulomatosis. 61
10902772 2000
14
Application of polymerase chain reaction assay in the diagnosis of orbital granuloma complicating atypical oculoglandular cat scratch disease. 61
9224472 1997
15
Indirect immunofluorescence study of the cornea and the conjunctiva in a xenogeneic system: analysis of humoral reactivity in patients with Wegener's granulomatosis. 61
8720676 1996
16
Experimental immunogenic granuloma of the orbit: transfer of granulomatous hypersensitivity with a subset of T lymphocytes. 61
3484474 1986
17
Orbital granuloma in Hodgkin's disease. 61
7316345 1981
18
Mycobacterium chelonei and orbital granuloma after tear duct probing. 61
7356779 1980
19
Orbital granuloma projecting through the upper fornix with a retained foreign body (record of an unusual case). 61
4637963 1972
20
Occlusion of the retinal artery in two cases of orbital granuloma. 61
5347174 1969
21
Extensive intracranial lesions in a case of orbital non-specific granuloma combined with polyarteritis nodosa. 61
13965307 1963
22
Bilateral orbital granuloma simulating a neoplasm. 61
15424922 1950
23
[Progressive scleroperikeratitis with postenucleatory orbital granuloma]. 61
24539166 1950

Variations for Orbital Granuloma

Expression for Orbital Granuloma

Search GEO for disease gene expression data for Orbital Granuloma.

Pathways for Orbital Granuloma

Pathways related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 PRTN3 MPO

GO Terms for Orbital Granuloma

Cellular components related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 PRTN3 MPO

Sources for Orbital Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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