MCID: ORB010
MIFTS: 27

Orbital Granuloma

Categories: Eye diseases

Aliases & Classifications for Orbital Granuloma

MalaCards integrated aliases for Orbital Granuloma:

Name: Orbital Granuloma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10499
ICD10 33 H05.11
ICD9CM 35 376.11
NCIt 50 C3653
SNOMED-CT 68 194008000 72776003
UMLS 73 C0155262

Summaries for Orbital Granuloma

MalaCards based summary : Orbital Granuloma is related to rheumatoid lung disease and ischemic fasciitis. An important gene associated with Orbital Granuloma is CYCS (Cytochrome C, Somatic), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Affiliated tissues include eye, and related phenotypes are hematopoietic system and immune system

Related Diseases for Orbital Granuloma

Diseases related to Orbital Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 rheumatoid lung disease 10.6 CD40LG MUC1
2 ischemic fasciitis 10.5 CD34 MUC1
3 selective igg deficiency disease 10.5 CD40LG CD79A
4 c1q nephropathy 10.4 CD40LG CD79A
5 meningovascular neurosyphilis 10.4 CD40LG CD79A
6 alpha chain disease 10.4 CD40LG CD79A
7 brill-zinsser disease 10.4 CD40LG CD79A
8 exudative glomerulonephritis 10.4 CD40LG CD79A
9 cork-handlers' disease 10.4 CD40LG CD79A
10 salpingo-oophoritis 10.4 CD40LG CD79A
11 early yaws 10.4 CD40LG CD79A
12 ventilation pneumonitis 10.4 CD40LG CD79A
13 chronic interstitial cystitis 10.4 CD40LG CD79A
14 axillary adenitis 10.4 CD40LG CD79A
15 cryofibrinogenemia 10.4 CD40LG CD79A
16 trichostrongyloidiasis 10.4 CD40LG CD79A
17 subacute bacterial endocarditis 10.4 CD40LG CD79A
18 heterophyiasis 10.4 CD40LG CD79A
19 immunoglobulin g deficiency 10.4 CD40LG CD79A
20 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
21 hyperglobulinemic purpura 10.4 CD40LG CD79A
22 gastroduodenitis 10.4 CD40LG CD79A
23 bacterial conjunctivitis 10.4 CD40LG CD79A
24 heavy chain disease 10.4 CD40LG CD79A
25 ophthalmia neonatorum 10.4 CD40LG CD79A
26 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
27 parotid disease 10.4 CD40LG CD79A
28 cerebral arteritis 10.4 CD40LG CD79A
29 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
30 geniculate herpes zoster 10.4 CD40LG CD79A
31 sporotrichosis 10.4 CD40LG CD79A
32 fallopian tube disease 10.4 CD40LG CD79A
33 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A
34 congenital syphilis 10.4 CD40LG CD79A
35 polyclonal hypergammaglobulinemia 10.4 CD40LG CD79A
36 salpingitis 10.4 CD40LG CD79A
37 ocular toxoplasmosis 10.4 CD40LG CD79A
38 dysgammaglobulinemia 10.4 CD40LG CD79A
39 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
40 acute maxillary sinusitis 10.4 CD40LG CD79A
41 chronic polyneuropathy 10.4 CD40LG CD79A
42 spinocerebellar ataxia, autosomal recessive 10 10.4 CD40LG CD79A
43 parasitic ichthyosporea infectious disease 10.4 CD40LG CD79A
44 cd40 ligand deficiency 10.4 CD40LG CD79A
45 rhinosporidiosis 10.4 CD40LG CD79A
46 secondary syphilis 10.4 CD40LG CD79A
47 yellow nail syndrome 10.4 CD40LG CD79A
48 congenital toxoplasmosis 10.4 CD40LG CD79A
49 chorioretinitis 10.4 CD40LG CD79A
50 asymptomatic neurosyphilis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Orbital Granuloma:



Diseases related to Orbital Granuloma

Symptoms & Phenotypes for Orbital Granuloma

MGI Mouse Phenotypes related to Orbital Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CSF3 CYCS PRTN3 CD34 CD40LG CD79A
2 immune system MP:0005387 9.1 CSF3 CYCS PRTN3 CD34 CD40LG CD79A

Drugs & Therapeutics for Orbital Granuloma

Search Clinical Trials , NIH Clinical Center for Orbital Granuloma

Genetic Tests for Orbital Granuloma

Anatomical Context for Orbital Granuloma

MalaCards organs/tissues related to Orbital Granuloma:

41
Eye

Publications for Orbital Granuloma

Articles related to Orbital Granuloma:

(show all 11)
# Title Authors Year
1
Orbital granuloma: a rare manifestation of extrapulmonary tuberculosis. ( 26933187 )
2016
2
A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. ( 27281484 )
2016
3
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases. ( 25413843 )
2014
4
Orbital granuloma annulare as presentation of systemic sarcoidosis. ( 23895369 )
2013
5
Clinical images: orbital granuloma and subglottic tracheal stenosis in Wegener's granulomatosis. ( 10902772 )
2000
6
Application of polymerase chain reaction assay in the diagnosis of orbital granuloma complicating atypical oculoglandular cat scratch disease. ( 9224472 )
1997
7
Orbital granuloma in Hodgkin's disease. ( 7316345 )
1981
8
Mycobacterium chelonei and orbital granuloma after tear duct probing. ( 7356779 )
1980
9
Orbital granuloma projecting through the upper fornix with a retained foreign body (record of an unusual case). ( 4637963 )
1972
10
Occlusion of the retinal artery in two cases of orbital granuloma. ( 5347174 )
1969
11
Bilateral orbital granuloma simulating a neoplasm. ( 15424922 )
1950

Variations for Orbital Granuloma

Expression for Orbital Granuloma

Search GEO for disease gene expression data for Orbital Granuloma.

Pathways for Orbital Granuloma

Pathways related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 CD34 CD40LG CD79A CSF3 MUC1 PRTN3
2 11.85 CD34 CD40LG CD79A
3 11.09 CD34 CD40LG
4 10.95 CD40LG CSF3
5 10.86 CD34 CD79A CSF3
6 10.52 CD40LG CD79A

GO Terms for Orbital Granuloma

Cellular components related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CD34 CD40LG CSF3 MUC1 PRTN3
2 external side of plasma membrane GO:0009897 8.8 CD34 CD40LG CD79A

Biological processes related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 CSF3 MUC1 PRTN3
2 B cell differentiation GO:0030183 9.32 CD40LG CD79A
3 negative regulation of neuron death GO:1901215 9.26 CD34 CSF3
4 B cell proliferation GO:0042100 8.96 CD40LG CD79A
5 positive regulation of interleukin-10 production GO:0032733 8.62 CD34 CD40LG

Sources for Orbital Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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