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MCID: ORB010
MIFTS: 26

Orbital Granuloma

Categories: Bone diseases
Genes Related diseases Publications Pathways
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Aliases & Classifications for Orbital Granuloma

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MalaCards integrated aliases for Orbital Granuloma:

Name: Orbital Granuloma 12 15 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases
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External Ids:

Disease Ontology 12 DOID:10499
ICD9CM 34 376.11
NCIt 50 C3653
SNOMED-CT 67 194008000
ICD10 32 H05.11
UMLS 71 C0155262
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Summaries for Orbital Granuloma

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MalaCards based summary : Orbital Granuloma is related to cat-scratch disease and granulomatosis with polyangiitis. An important gene associated with Orbital Granuloma is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are hematopoietic system and immune system

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Related Diseases for Orbital Granuloma

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Diseases related to Orbital Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 cat-scratch disease 30.1 CRP ACE
2 granulomatosis with polyangiitis 29.7 TNFSF13B PRTN3 MPO CRP CD34
3 allergic cutaneous vasculitis 10.4 PRTN3 MPO
4 frontal sinusitis 10.4 PRTN3 CRP
5 orbital plasma cell granuloma 10.4 PRTN3 CRP
6 bicipital tenosynovitis 10.4 PRTN3 CRP
7 tenosynovitis 10.4 PRTN3 CRP
8 ethmoid sinusitis 10.4 PRTN3 CRP
9 acute dacryoadenitis 10.4 CRP ACE
10 acute frontal sinusitis 10.4 PRTN3 MPO
11 mediastinum teratoma 10.4 CRP ACE
12 anca-associated vasculitis 10.4 PRTN3 MPO
13 cardiac tuberculosis 10.4 CRP ACE
14 skeletal tuberculosis 10.4 ESX1 CRP
15 rheumatoid arthritis interstitial lung disease 10.4 MUC1 CRP
16 breast abscess 10.4 MUC1 CRP
17 lipid pneumonia 10.4 MUC1 CRP
18 mediastinitis 10.4 MPO CRP
19 silent myocardial infarction 10.4 CRP ACE
20 urinary tract infection 10.4 CRP ACE
21 ankylosing spondylitis 3 10.4 FCGRT CRP
22 pulmonary hemosiderosis 10.4 PRTN3 MPO
23 neuroretinitis 10.4 CRP ACE
24 purulent acute otitis media 10.4 PRTN3 MPO CRP
25 scleritis 10.3 PRTN3 MPO CRP
26 optic papillitis 10.3 CRP ACE
27 subacute bacterial endocarditis 10.3 PRTN3 MPO CRP
28 mastoiditis 10.3 PRTN3 MPO CRP
29 aortitis 10.3 PRTN3 MPO CRP
30 chondromalacia 10.3 PRTN3 MPO CRP
31 maxillary sinusitis 10.3 PRTN3 MPO CRP
32 b-cell non-hodgkin lymphoma 10.3 TNFSF13B LCP1
33 autoimmune vasculitis 10.3 PRTN3 MPO CRP
34 lymph node tuberculosis 10.3 LTA4H CRP
35 cholangitis 10.3 PRTN3 MPO CRP
36 acute proliferative glomerulonephritis 10.3 PRTN3 MPO CRP
37 rapidly progressive glomerulonephritis 10.3 PRTN3 MPO CRP
38 ecthyma 10.3 CSF3 CRP
39 cranial nerve palsy 10.3 PRTN3 CRP ACE
40 marginal corneal ulcer 10.3 MPO CRP
41 middle ear disease 10.3 PRTN3 MPO CRP
42 splenic tuberculosis 10.3 PRTN3 CRP
43 anterior scleritis 10.3 PRTN3 CRP ACE
44 mikulicz disease 10.3 TNFSF13B CRP
45 posterior scleritis 10.3 PRTN3 CRP ACE
46 tolosa-hunt syndrome 10.3 PRTN3 CRP ACE
47 pyomyositis 10.3 CSF3 CRP
48 chronic orbital inflammation 10.3 PRTN3 CRP ACE
49 splenic abscess 10.3 CSF3 CRP
50 granulomatous angiitis 10.3 PRTN3 CRP ACE

Graphical network of the top 20 diseases related to Orbital Granuloma:



Diseases related to Orbital Granuloma
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Symptoms & Phenotypes for Orbital Granuloma

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MGI Mouse Phenotypes related to Orbital Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 ACE ADAMTS13 CD22 CD34 CSF3 FCGR2B
2 immune system MP:0005387 9.58 ACE ADAMTS13 CD22 CD34 CRP CSF3
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Drugs & Therapeutics for Orbital Granuloma

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Search Clinical Trials , NIH Clinical Center for Orbital Granuloma

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Genetic Tests for Orbital Granuloma

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Anatomical Context for Orbital Granuloma

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Publications for Orbital Granuloma

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Articles related to Orbital Granuloma:

(show all 24)
# Title Authors PMID Year
1
Orbital granuloma formation following autoinjection of paraffin oil: management considerations. 61
33186437 2020
2
Massive Silicone-Induced Orbital Granuloma. 61
32258023 2020
3
[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement]. 61
30499537 2018
4
A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. 61
27281484 2017
5
Orbital granuloma: a rare manifestation of extrapulmonary tuberculosis. 61
26933187 2016
6
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases. 61
25413843 2015
7
Sarcoidosis in the national veteran population: association of ocular inflammation and mortality. 61
25687027 2015
8
Orbital granuloma annulare as presentation of systemic sarcoidosis. 61
23895369 2013
9
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. 61
22021864 2012
10
Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis. 61
18321200 2008
11
[Successful treatment with rituximab in a refractory Wegener's granulomatosis with hypertrophic pachymeningitis and the right orbital granuloma]. 61
17682433 2007
12
[Successful treatment of a patient with refractory Wegener's granulomatosis by rituximab]. 61
17473516 2007
13
A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease. 61
16126798 2006
14
Clinical images: orbital granuloma and subglottic tracheal stenosis in Wegener's granulomatosis. 61
10902772 2000
15
Application of polymerase chain reaction assay in the diagnosis of orbital granuloma complicating atypical oculoglandular cat scratch disease. 61
9224472 1997
16
Indirect immunofluorescence study of the cornea and the conjunctiva in a xenogeneic system: analysis of humoral reactivity in patients with Wegener's granulomatosis. 61
8720676 1996
17
Experimental immunogenic granuloma of the orbit: transfer of granulomatous hypersensitivity with a subset of T lymphocytes. 61
3484474 1986
18
Orbital granuloma in Hodgkin's disease. 61
7316345 1981
19
Mycobacterium chelonei and orbital granuloma after tear duct probing. 61
7356779 1980
20
Orbital granuloma projecting through the upper fornix with a retained foreign body (record of an unusual case). 61
4637963 1972
21
Occlusion of the retinal artery in two cases of orbital granuloma. 61
5347174 1969
22
Extensive intracranial lesions in a case of orbital non-specific granuloma combined with polyarteritis nodosa. 61
13965307 1963
23
Bilateral orbital granuloma simulating a neoplasm. 61
15424922 1950
24
[Progressive scleroperikeratitis with postenucleatory orbital granuloma]. 61
24539166 1950
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Variations for Orbital Granuloma

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Expression for Orbital Granuloma

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Search GEO for disease gene expression data for Orbital Granuloma.
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Pathways for Orbital Granuloma

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Pathways related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.03 TRIM21 TNFSF13B TNFRSF25 TNFRSF13B PRTN3 MUC1
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.02 TRIM21 TNFSF13B TNFRSF25 TNFRSF13B PRTN3 MUC1
3
NF-kappaB Signaling 4
12.07 TNFSF13B TNFRSF25 MPO LCP1 CD34
4
Hematopoietic cell lineage 36
11.63 CSF3 CD34 CD22
5
TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.52 TNFSF13B TNFRSF25 TNFRSF13B
6
C-MYB transcription factor network 1
11.47 PRTN3 MPO CD34
7
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.36 TNFSF13B TNFRSF25 TNFRSF13B
8
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.32 MPO CSF3 CD34 CD22
9
IgA-Producing B Cells in the Intestine 64
11.25 TNFSF13B TNFRSF13B FCGR2B
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GO Terms for Orbital Granuloma

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Cellular components related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNFSF13B TNFRSF25 PRTN3 MUC1 MPO LTA4H
2 external side of plasma membrane GO:0009897 9.55 FCGRT FCGR2B CD34 CD22 ACE
3 extracellular space GO:0005615 9.32 TNFSF13B PRTN3 MUC1 MPO LCP1 FCGRT

Biological processes related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.46 TNFSF13B FCGR2B CD34 CD22
2 positive regulation of protein binding GO:0032092 9.43 TRIM21 CSF3 ACE
3 negative regulation of immunoglobulin production GO:0002638 9.32 FCGR2B CD22
4 negative regulation of B cell receptor signaling pathway GO:0050859 8.96 FCGR2B CD22
5 peptide catabolic process GO:0043171 8.8 LTA4H ADAMTS13 ACE

Molecular functions related to Orbital Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 TRIM21 TNFSF13B TNFRSF25 TNFRSF13B SSB SLC7A11
2 IgG binding GO:0019864 8.62 FCGRT FCGR2B
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Sources for Orbital Granuloma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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