MCID: ORB014
MIFTS: 27

Orbital Lymphangioma

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Orbital Lymphangioma

MalaCards integrated aliases for Orbital Lymphangioma:

Name: Orbital Lymphangioma 53

Classifications:



Summaries for Orbital Lymphangioma

MalaCards based summary : Orbital Lymphangioma is related to lymphangioma and lymphangiomatosis. An important gene associated with Orbital Lymphangioma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Apoptosis Pathway. Affiliated tissues include endothelial and retina, and related phenotypes are digestive/alimentary and integument

Related Diseases for Orbital Lymphangioma

Graphical network of the top 20 diseases related to Orbital Lymphangioma:



Diseases related to Orbital Lymphangioma

Symptoms & Phenotypes for Orbital Lymphangioma

MGI Mouse Phenotypes related to Orbital Lymphangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.33 FLT4 PDPN EGFR
2 integument MP:0010771 9.13 FLT4 PDPN EGFR
3 muscle MP:0005369 8.8 FLT4 PDPN EGFR

Drugs & Therapeutics for Orbital Lymphangioma

Search Clinical Trials , NIH Clinical Center for Orbital Lymphangioma

Genetic Tests for Orbital Lymphangioma

Anatomical Context for Orbital Lymphangioma

MalaCards organs/tissues related to Orbital Lymphangioma:

41
Endothelial, Retina

Publications for Orbital Lymphangioma

Articles related to Orbital Lymphangioma:

(show all 49)
# Title Authors Year
1
Sirolimus-induced regression of a large orbital lymphangioma. ( 29405800 )
2018
2
A prospective study of the role of intralesional bleomycin in orbital lymphangioma. ( 28300684 )
2017
3
Sclerotherapy for Orbital Lymphangioma - Case Series and Literature Review. ( 28358710 )
2017
4
WITHDRAWN: Role of Intralesional Bleomycin in Orbital Lymphangioma: A Prospective Study. ( 28579136 )
2017
5
Orbital Lymphangioma: Characteristics and Treatment Outcomes of 12 Cases. ( 28534344 )
2017
6
Successful treatment of orbital lymphangioma with intralesional bleomycin and application of continuous negative pressure. ( 25646065 )
2015
7
Sildenafil for pediatric orbital lymphangioma. ( 23828510 )
2013
8
Orbital lymphangioma in a child: a diagnostic dilemma. ( 23620979 )
2012
9
Occasional finding of a dural arteriovenous fistula in a newborn with orbital lymphangioma. A case report. ( 24148537 )
2010
10
Misleading presentation of an orbital lymphangioma. ( 20031456 )
2010
11
Orbital lymphangioma treated by lateral wall decompression and fat removal. ( 20401573 )
2010
12
D-dimer evaluation of hemorrhagic orbital lymphangioma. ( 20524228 )
2010
13
Congenital orbital lymphangioma in a 20-years old girl a case report and review of literature. ( 21483541 )
2009
14
Sclerosing therapy for orbital lymphangioma using sodium tetradecyl sulfate. ( 18773268 )
2008
15
Bilateral orbital lymphangiomas in two patients with generalized lymphangiomatosis. ( 17353319 )
2007
16
Intralesional injection of OK-432 for vision-threatening orbital lymphangioma. ( 17577592 )
2007
17
Persistent fetal vasculature associated with orbital lymphangioma. ( 17572349 )
2007
18
Late-onset presentation of orbital lymphangioma. ( 17413621 )
2007
19
Persistent fetal vasculature associated with orbital lymphangioma. ( 16814189 )
2006
20
Resection of an orbital lymphangioma with the aid of an intralesional liquid polymer. ( 16286413 )
2005
21
Retinal folds as initial manifestation of orbital lymphangioma. ( 16344454 )
2005
22
A case of orbital lymphangioma showing considerable shrinkage after limiting dissection. ( 15043553 )
2004
23
Orbital lymphangioma and its association with intracranial venous angioma. ( 15176559 )
2004
24
Orbital lymphangioma. ( 15234158 )
2004
25
Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications. ( 15590529 )
2004
26
Histopathological study of orbital lymphangioma in an infant. ( 15592788 )
2004
27
Two cases of orbital lymphangioma associated with vascular abnormalities of the retina and iris. ( 14711734 )
2004
28
Orbital decompression for gross proptosis associated with orbital lymphangioma. ( 15599249 )
2004
29
Orbital lymphangioma with non-contiguous cerebral arteriovenous malformation, manifesting with thrombocytopenia (Kasabach-Merritt syndrome) and intracerebral hemorrhage. ( 11883828 )
2002
30
Bilateral multiple orbital Lymphangiomas in a patient with systemic lymphangiomatosis. ( 11911542 )
2002
31
Orbital cellulitis due to occult orbital lymphangioma. ( 11372810 )
2001
32
Orbital lymphangioma: clinical features and management. ( 12455141 )
2001
33
Orbital lymphangioma with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and podoplanin). ( 11585321 )
2001
34
Conservative management of orbital lymphangioma. ( 10714694 )
2000
35
Orbital lymphangioma. ( 10611113 )
2000
36
Management of orbital lymphangioma using intralesional injection of OK-432. ( 10837387 )
2000
37
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. ( 10588254 )
1999
38
Orbital lymphangioma: an analysis of 26 patients. ( 10209440 )
1999
39
Orbital lymphangioma with intracranial extension. ( 7748818 )
1995
40
Unequal refractive error and high astigmatism associated with orbital lymphangioma. ( 8361606 )
1993
41
Magnetic resonance imaging of orbital lymphangioma with and without gadolinium contrast enhancement. ( 1513586 )
1992
42
Orbital lymphangioma. Correlation of magnetic resonance images and intraoperative findings. ( 1454327 )
1992
43
An analysis of thirty cases of orbital lymphangioma. Pathophysiologic considerations and management recommendations. ( 2087290 )
1990
44
Conservative management of childhood orbital lymphangioma. ( 2726177 )
1989
45
Orbital lymphangioma. ( 3399564 )
1988
46
Surgical management of orbital lymphangioma with the carbon dioxide laser. ( 3752195 )
1986
47
Tumor conference No. 29. An orbital lymphangioma. ( 7381109 )
1980
48
Orbital lymphangioma (regression with corticosteroids). ( 1031384 )
1976
49
Secondary glaucoma caused by orbital lymphangioma. ( 4678266 )
1972

Variations for Orbital Lymphangioma

Expression for Orbital Lymphangioma

Search GEO for disease gene expression data for Orbital Lymphangioma.

Pathways for Orbital Lymphangioma

Pathways related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 EGFR FLT4
2
Show member pathways
11.83 EGFR FLT4
3
Show member pathways
11.75 EGFR FLT4
4 11.48 EGFR FLT4
5 11.43 EGFR FLT4
6
Show member pathways
11.14 EGFR FLT4
7 11.11 FLT4 PDPN
8 10.25 EGFR FLT4

GO Terms for Orbital Lymphangioma

Cellular components related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.33 EGFR FLT4 PDPN
2 membrane raft GO:0045121 9.26 EGFR PDPN
3 basolateral plasma membrane GO:0016323 8.96 EGFR PDPN
4 receptor complex GO:0043235 8.62 EGFR FLT4

Biological processes related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.63 EGFR FLT4 PDPN
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.54 EGFR FLT4
3 positive regulation of cell migration GO:0030335 9.52 EGFR PDPN
4 protein autophosphorylation GO:0046777 9.51 EGFR FLT4
5 peptidyl-tyrosine phosphorylation GO:0018108 9.49 EGFR FLT4
6 positive regulation of protein phosphorylation GO:0001934 9.48 EGFR FLT4
7 positive regulation of MAPK cascade GO:0043410 9.43 EGFR FLT4
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.4 EGFR FLT4
9 negative regulation of signal transduction GO:0009968 9.37 EGFR FLT4
10 cell morphogenesis GO:0000902 9.32 EGFR PDPN
11 lung development GO:0030324 9.26 EGFR PDPN
12 positive regulation of kinase activity GO:0033674 9.16 EGFR FLT4
13 negative regulation of apoptotic process GO:0043066 9.13 EGFR FLT4 PDPN
14 lymphangiogenesis GO:0001946 8.62 FLT4 PDPN

Molecular functions related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.32 EGFR FLT4
2 MAP kinase kinase kinase activity GO:0004709 9.26 EGFR FLT4
3 protein phosphatase binding GO:0019903 9.16 EGFR FLT4
4 mitogen-activated protein kinase kinase binding GO:0031434 8.96 EGFR FLT4
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 EGFR FLT4

Sources for Orbital Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....