MCID: ORB014
MIFTS: 23

Orbital Lymphangioma

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Orbital Lymphangioma

MalaCards integrated aliases for Orbital Lymphangioma:

Name: Orbital Lymphangioma 20

Classifications:



Summaries for Orbital Lymphangioma

MalaCards based summary : Orbital Lymphangioma is related to lymphangioma and rare lymphatic malformation. An important gene associated with Orbital Lymphangioma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Apoptosis Pathway and RhoGDI Pathway. Affiliated tissues include endothelial, retina and brain, and related phenotypes are digestive/alimentary and muscle

Related Diseases for Orbital Lymphangioma

Diseases related to Orbital Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 30.4 PDPN FLT4 EGFR
2 rare lymphatic malformation 10.8
3 exophthalmos 10.6
4 ptosis 10.3
5 optic nerve disease 10.3
6 keratopathy 10.2
7 persistent hyperplastic primary vitreous, autosomal recessive 10.1
8 suppression amblyopia 10.1
9 amblyopia 10.1
10 orbital cellulitis 10.0
11 cellulitis 10.0
12 supraglottis cancer 9.9 PDPN EGFR
13 laryngeal benign neoplasm 9.9 PDPN EGFR
14 pleomorphic carcinoma 9.9 PDPN EGFR
15 penile cancer 9.9 PDPN EGFR
16 arteriovenous malformations of the brain 9.9
17 hemangioma-thrombocytopenia syndrome 9.9
18 astigmatism 9.9
19 persistent hyperplastic primary vitreous 9.9
20 brown's tendon sheath syndrome 9.9
21 hydrocephalus 9.9
22 arteriovenous malformation 9.9
23 intermittent proptosis 9.9
24 ocular motility disease 9.9
25 thrombocytopenia 9.9
26 cystic lymphangioma 9.9
27 refractive error 9.9
28 pre-malignant neoplasm 9.9 PDPN EGFR
29 in situ carcinoma 9.9 PDPN EGFR
30 hemangioblastoma 9.9 PDPN EGFR
31 congenital lymphedema 9.8 PDPN FLT4
32 lymphangioleiomyomatosis 9.8 PDPN EGFR
33 hobnail hemangioma 9.8 PDPN FLT4
34 hemangioma 9.8 PDPN FLT4
35 capillary lymphangioma 9.8 PDPN FLT4
36 lymphangiosarcoma 9.8 PDPN FLT4
37 angiosarcoma 9.8 PDPN FLT4
38 gorham's disease 9.8 PDPN FLT4
39 malignant pleural mesothelioma 9.8 PDPN EGFR
40 lymphangitis 9.8 PDPN FLT4
41 capillary hemangioma 9.8 PDPN FLT4
42 gallbladder disease 9.8 PDPN EGFR
43 hereditary lymphedema i 9.8 PDPN FLT4
44 vascular cancer 9.8 PDPN FLT4
45 cardiovascular organ benign neoplasm 9.8 PDPN FLT4
46 lung squamous cell carcinoma 9.7 PDPN EGFR
47 breast carcinoma in situ 9.7 FLT4 EGFR
48 mesothelioma, malignant 9.7 PDPN FLT4
49 adenoid cystic carcinoma 9.6 PDPN EGFR
50 kidney cancer 9.5 FLT4 EGFR

Graphical network of the top 20 diseases related to Orbital Lymphangioma:



Diseases related to Orbital Lymphangioma

Symptoms & Phenotypes for Orbital Lymphangioma

MGI Mouse Phenotypes related to Orbital Lymphangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.13 EGFR FLT4 PDPN
2 muscle MP:0005369 8.8 EGFR FLT4 PDPN

Drugs & Therapeutics for Orbital Lymphangioma

Search Clinical Trials , NIH Clinical Center for Orbital Lymphangioma

Genetic Tests for Orbital Lymphangioma

Anatomical Context for Orbital Lymphangioma

MalaCards organs/tissues related to Orbital Lymphangioma:

40
Endothelial, Retina, Brain, Kidney, Lung, Breast

Publications for Orbital Lymphangioma

Articles related to Orbital Lymphangioma:

(show top 50) (show all 80)
# Title Authors PMID Year
1
Orbital Lymphangioma Confined to an Extraocular Muscle. 61
31868796 2020
2
A Case of Adult Orbital Intraconal Lymphangioma. 61
32181195 2020
3
Management of a case of orbital lymphangioma presenting in adulthood with negative-pressure aspiration and bleomycin injection. 61
31177193 2019
4
Interventions for orbital lymphangioma. 61
31094450 2019
5
Sirolimus-induced regression of a large orbital lymphangioma. 61
29405800 2019
6
A rare case of orbital lymphangioma with persistent fetal vasculature and extraorbital vascular malformations treated with intralesional bleomycin. 61
30120984 2018
7
A Case of Intraorbital Intraconal Lymphangioma with Post-traumatic Apoplexy. 61
30090138 2018
8
Orbital Lymphangioma: Characteristics and Treatment Outcomes of 12 Cases. 61
28534344 2017
9
ACCIDENTAL DUPLICATION: Role of Intralesional Bleomycin in Orbital Lymphangioma: A Prospective Study. 61
28579136 2017
10
A prospective study of the role of intralesional bleomycin in orbital lymphangioma. 61
28300684 2017
11
Sclerotherapy for Orbital Lymphangioma - Case Series and Literature Review. 61
28358710 2017
12
The use of a three-dimensional endoscope for different skull base tumors: results of a preliminary extended endonasal surgical series. 61
27278644 2016
13
Successful treatment of orbital lymphangioma with intralesional bleomycin and application of continuous negative pressure. 61
25646065 2015
14
[Sclerotization of orbital lymphangioma with OK-432]. 61
24706253 2014
15
Intralesional bleomycin: a potential treatment for refractory orbital lymphangiomas. 61
24025999 2014
16
[Lymphangioma of the orbitopalpebral area]. 61
25354822 2014
17
Sildenafil for pediatric orbital lymphangioma. 61
23828510 2013
18
[Orbital lymphangioma]. 61
22810001 2013
19
Orbital lymphangioma in a child: a diagnostic dilemma. 61
23620979 2012
20
Orbital lymphangiomas: a review of management strategies. 61
22828166 2012
21
[A 2-year-old patient with acute proptosis]. 61
22581050 2012
22
Conjunctival lymphangioma: a case report and brief review of the literature. 61
22666617 2012
23
[Unsuccessful treatment with OK-432 picibanil for orbital lymphangioma]. 61
22248653 2012
24
[Lymphatic malformations in the head and neck: experiences with sclerotherapy]. 61
21509618 2011
25
D-dimer evaluation of hemorrhagic orbital lymphangioma. 61
20524228 2010
26
Occasional finding of a dural arteriovenous fistula in a newborn with orbital lymphangioma. A case report. 61
24148537 2010
27
Orbital lymphangioma treated by lateral wall decompression and fat removal. 61
20401573 2010
28
Misleading presentation of an orbital lymphangioma. 61
20031456 2010
29
[Orbital lymphangioma: case report]. 61
20464121 2010
30
Congenital orbital lymphangioma in a 20-years old girl a case report and review of literature. 61
21483541 2009
31
Successful treatment of intraorbital lymphangioma with tissue fibrin glue. 61
19828182 2009
32
[A variety of orbital lymphangioma treatments: one case treated with orbital decompression therapy and the other case with intralesional injection of OK-432 therapy]. 61
19637816 2009
33
[Surgical treatment of diffuse adult orbital lymphangioma: two case studies]. 61
19107078 2008
34
Sclerosing therapy for orbital lymphangioma using sodium tetradecyl sulfate. 61
18773268 2008
35
Intralesional injection of OK-432 for vision-threatening orbital lymphangioma. 61
17577592 2007
36
Persistent fetal vasculature associated with orbital lymphangioma. 61
17572349 2007
37
Late-onset presentation of orbital lymphangioma. 61
17413621 2007
38
Persistent fetal vasculature associated with orbital lymphangioma. 61
16814189 2006
39
Nonpreserved human amniotic membrane transplantation for conjunctival reconstruction after excision of extensive ocular surface neoplasia. 61
15877097 2006
40
Sclerosing therapy as first line treatment for low flow vascular lesions of the orbit. 61
16458690 2006
41
Retinal folds as initial manifestation of orbital lymphangioma. 61
16344454 2005
42
Resection of an orbital lymphangioma with the aid of an intralesional liquid polymer. 61
16286413 2005
43
Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications. 61
15590529 2004
44
Orbital decompression for gross proptosis associated with orbital lymphangioma. 61
15599249 2004
45
Histopathological study of orbital lymphangioma in an infant. 61
15592788 2004
46
Orbital lymphangioma. 61
15234158 2004
47
A case of orbital lymphangioma showing considerable shrinkage after limiting dissection. 61
15043553 2004
48
Orbital lymphangioma and its association with intracranial venous angioma. 61
15176559 2004
49
Two cases of orbital lymphangioma associated with vascular abnormalities of the retina and iris. 61
14711734 2004
50
Orbital lymphangioma with non-contiguous cerebral arteriovenous malformation, manifesting with thrombocytopenia (Kasabach-Merritt syndrome) and intracerebral hemorrhage. 61
11883828 2002

Variations for Orbital Lymphangioma

Expression for Orbital Lymphangioma

Search GEO for disease gene expression data for Orbital Lymphangioma.

Pathways for Orbital Lymphangioma

Pathways related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 FLT4 EGFR
2
Show member pathways
11.7 FLT4 EGFR
3 11.64 FLT4 EGFR
4 11.33 FLT4 EGFR
5 10.91 PDPN FLT4
6 10.26 FLT4 EGFR

GO Terms for Orbital Lymphangioma

Cellular components related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.26 PDPN EGFR
2 basolateral plasma membrane GO:0016323 9.16 PDPN EGFR
3 receptor complex GO:0043235 8.96 FLT4 EGFR
4 integral component of plasma membrane GO:0005887 8.8 PDPN FLT4 EGFR

Biological processes related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.58 PDPN FLT4 EGFR
2 positive regulation of cell migration GO:0030335 9.51 PDPN EGFR
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.49 FLT4 EGFR
4 positive regulation of protein phosphorylation GO:0001934 9.48 FLT4 EGFR
5 cell-cell adhesion GO:0098609 9.46 PDPN EGFR
6 protein autophosphorylation GO:0046777 9.43 FLT4 EGFR
7 peptidyl-tyrosine phosphorylation GO:0018108 9.37 FLT4 EGFR
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.32 FLT4 EGFR
9 lung development GO:0030324 9.26 PDPN EGFR
10 positive regulation of kinase activity GO:0033674 9.16 FLT4 EGFR
11 negative regulation of apoptotic process GO:0043066 9.13 PDPN FLT4 EGFR
12 lymphangiogenesis GO:0001946 8.62 PDPN FLT4

Molecular functions related to Orbital Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.16 FLT4 EGFR
2 protein phosphatase binding GO:0019903 8.96 FLT4 EGFR
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 FLT4 EGFR

Sources for Orbital Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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