MCID: ORB015
MIFTS: 23

Orbital Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Orbital Melanoma

MalaCards integrated aliases for Orbital Melanoma:

Name: Orbital Melanoma 53 73

Classifications:



External Ids:

UMLS 73 C3898089

Summaries for Orbital Melanoma

MalaCards based summary : Orbital Melanoma is related to ocular melanoma and melanoma. An important gene associated with Orbital Melanoma is CANX (Calnexin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Allograft rejection. Affiliated tissues include prostate.

Related Diseases for Orbital Melanoma

Diseases related to Orbital Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 ocular melanoma 11.1
2 melanoma 10.4
3 tièche-jadassohn nevus 9.8
4 choroiditis 9.8
5 rosai-dorfman disease 9.6
6 lymphoma, mucosa-associated lymphoid type 9.6
7 lymphoma 9.6
8 orbital cellulitis 9.6
9 prostatitis 9.6
10 cellulitis 9.6
11 maxillary sinus squamous cell carcinoma 9.6 CANX TAPBP
12 suppurative cholangitis 9.5 CANX TAPBP
13 immunodeficiency by defective expression of hla class 1 9.4 TAP1 TAPBP
14 bare lymphocyte syndrome, type i 9.0 TAP1 TAPBP

Graphical network of the top 20 diseases related to Orbital Melanoma:



Diseases related to Orbital Melanoma

Symptoms & Phenotypes for Orbital Melanoma

Drugs & Therapeutics for Orbital Melanoma

Search Clinical Trials , NIH Clinical Center for Orbital Melanoma

Genetic Tests for Orbital Melanoma

Anatomical Context for Orbital Melanoma

MalaCards organs/tissues related to Orbital Melanoma:

41
Prostate

Publications for Orbital Melanoma

Articles related to Orbital Melanoma:

(show all 39)
# Title Authors Year
1
Correction to: Figueira et al., Primary orbital melanoma: a case series and literature review. ( 29513628 )
2018
2
Primary orbital melanoma: a case series and literature review. ( 29388848 )
2018
3
Primary orbital melanoma treated with orbital exenteration and postoperative radiotherapy: A case report and review of the literature. ( 29394463 )
2018
4
Giant Orbital Melanoma in a Heroin Abuser. ( 28559841 )
2017
5
Orbital melanoma masquerading as a "Galloping haemangioma". ( 28388343 )
2017
6
Malignant Orbital Melanoma Associated with Oculodermal Melanocytosis. ( 28335938 )
2017
7
Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients. ( 29326884 )
2017
8
New Translational Research in the Medical Management of Orbital Melanoma. ( 26959130 )
2016
9
Melanoma-Associated Spongiform Scleropathy in Oculodermal Melanocytosis with Primary Orbital Melanoma. ( 27843909 )
2016
10
Orbital melanoma with calcification: A diagnostic dilemma. ( 28112137 )
2016
11
Primary orbital melanoma combined with giant divided nevus of the eyelid. ( 24406601 )
2014
12
Primary orbital melanoma in association with cellular blue nevus. ( 27843414 )
2014
13
Orbital melanoma: Recurrence versus primary: A diagnostic dilemma. ( 25494149 )
2014
14
Orbital melanoma. ( 21863619 )
2011
15
Primary orbital melanoma with poliosis and a palpable mass. ( 21987690 )
2011
16
Palliative surgery for contralateral metastasis of orbital melanoma to prevent blindness. ( 18925919 )
2008
17
Characterization of an orbital melanoma and mucosa associated lymphoid tissue (MALT) lymphoma by dual phase N-isopropyl-p-I-123 iodoamphetamine. ( 17667440 )
2007
18
Contralateral orbital melanoma 28 years following enucleation for choroidal melanoma. ( 18097971 )
2007
19
Primary orbital melanoma treated with iodine-125 plaque radiotherapy. ( 17056373 )
2006
20
Primary orbital melanoma without ocular involvement in a Balinese cat. ( 16604977 )
2006
21
Primary orbital melanoma associated with a blue nevus. ( 15942508 )
2005
22
Unusual metastatic features in a patient with concomitant malignant orbital melanoma and prostate carcinoma. ( 15015669 )
2004
23
Aggressive primary orbital melanoma in a young white man with no predisposing ocular features. ( 14718309 )
2004
24
Primary orbital melanoma associated with an occult episcleral nevus. ( 14769613 )
2004
25
Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma. ( 14685899 )
2003
26
Loss of antigen-processing molecules in primary orbital melanoma. ( 14685900 )
2003
27
Primary orbital melanoma masquerading as vascular anomalies. ( 11913882 )
2002
28
Orbital melanoma metastatic from contralateral choroid: management by complete surgical resection. ( 12358296 )
2002
29
Primary orbital melanoma associated with oculodermal melanocytosis. ( 12045961 )
2000
30
Primary orbital melanoma in a child. ( 10918242 )
2000
31
Orbital melanoma presenting as orbital cellulitis: a clinicopathologic report. ( 9700739 )
1998
32
A case of primary orbital melanoma treated by local excision. ( 8562560 )
1995
33
Necrotic orbital melanoma arising de novo. ( 8457515 )
1993
34
Primary orbital melanoma associated with orbital melanocytosis. ( 2383203 )
1990
35
Orbital melanoma. ( 7294632 )
1981
36
Primary orbital melanoma. ( 718518 )
1978
37
Primary orbital melanoma. ( 4835051 )
1974
38
Primary orbital melanoma. ( 5946390 )
1966
39
AN ENCAPSULATED ORBITAL MELANOMA. ( 18170019 )
1944

Variations for Orbital Melanoma

Expression for Orbital Melanoma

Search GEO for disease gene expression data for Orbital Melanoma.

Pathways for Orbital Melanoma

GO Terms for Orbital Melanoma

Cellular components related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.54 CANX TAP1 TAPBP
2 endoplasmic reticulum membrane GO:0005789 9.5 CANX TAP1 TAPBP
3 phagocytic vesicle membrane GO:0030670 9.26 TAP1 TAPBP
4 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.16 TAP1 TAPBP
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 CANX TAPBP
6 TAP complex GO:0042825 8.62 TAP1 TAPBP

Biological processes related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.37 TAP1 TAPBP
2 peptide transport GO:0015833 9.32 TAP1 TAPBP
3 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 TAP1 TAPBP
4 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.16 TAP1 TAPBP
5 amide transport GO:0042886 8.96 TAP1 TAPBP
6 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.8 CANX TAP1 TAPBP

Molecular functions related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 unfolded protein binding GO:0051082 9.37 CANX TAPBP
2 peptide antigen binding GO:0042605 9.32 TAP1 TAPBP
3 MHC class I protein binding GO:0042288 9.26 TAP1 TAPBP
4 TAP1 binding GO:0046978 9.16 TAP1 TAPBP
5 peptide antigen-transporting ATPase activity GO:0015433 8.96 TAP1 TAPBP
6 TAP2 binding GO:0046979 8.62 TAP1 TAPBP

Sources for Orbital Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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