MCID: ORB015
MIFTS: 26

Orbital Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Orbital Melanoma

MalaCards integrated aliases for Orbital Melanoma:

Name: Orbital Melanoma 54 74

Classifications:



External Ids:

UMLS 74 C3898089

Summaries for Orbital Melanoma

MalaCards based summary : Orbital Melanoma is related to melanoma and maxillary sinus squamous cell carcinoma. An important gene associated with Orbital Melanoma is CANX (Calnexin), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. Affiliated tissues include prostate and skin, and related phenotypes are G0/1 arrest and Multipolar spindles

Related Diseases for Orbital Melanoma

Graphical network of the top 20 diseases related to Orbital Melanoma:



Diseases related to Orbital Melanoma

Symptoms & Phenotypes for Orbital Melanoma

GenomeRNAi Phenotypes related to Orbital Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 9.13 CANX SF3B1 TAPBP
2 Multipolar spindles GR00222-A-1 8.62 EIF1AX SF3B1

MGI Mouse Phenotypes related to Orbital Melanoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 CANX GNAQ SF3B1 TAP1 TAPBP

Drugs & Therapeutics for Orbital Melanoma

Search Clinical Trials , NIH Clinical Center for Orbital Melanoma

Genetic Tests for Orbital Melanoma

Anatomical Context for Orbital Melanoma

MalaCards organs/tissues related to Orbital Melanoma:

42
Prostate, Skin

Publications for Orbital Melanoma

Articles related to Orbital Melanoma:

(show all 41)
# Title Authors Year
1
Genetic Profiling of Primary Orbital Melanoma-An Analysis of 6 Cases with Clinico-Pathological Correlation. ( 30605742 )
2018
2
Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis. ( 30558566 )
2018
3
Primary orbital melanoma: a case series and literature review. ( 29388848 )
2018
4
Primary orbital melanoma treated with orbital exenteration and postoperative radiotherapy: A case report and review of the literature. ( 29394463 )
2018
5
Correction to: Figueira et al., Primary orbital melanoma: a case series and literature review. ( 29513628 )
2018
6
Malignant Orbital Melanoma Associated with Oculodermal Melanocytosis. ( 28335938 )
2017
7
Orbital melanoma masquerading as a "Galloping haemangioma". ( 28388343 )
2017
8
Giant Orbital Melanoma in a Heroin Abuser. ( 28559841 )
2017
9
Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients. ( 29326884 )
2017
10
New Translational Research in the Medical Management of Orbital Melanoma. ( 26959130 )
2016
11
Melanoma-Associated Spongiform Scleropathy in Oculodermal Melanocytosis with Primary Orbital Melanoma. ( 27843909 )
2016
12
Orbital melanoma with calcification: A diagnostic dilemma. ( 28112137 )
2016
13
Primary orbital melanoma combined with giant divided nevus of the eyelid. ( 24406601 )
2014
14
Orbital melanoma: Recurrence versus primary: A diagnostic dilemma. ( 25494149 )
2014
15
Primary orbital melanoma in association with cellular blue nevus. ( 27843414 )
2014
16
Orbital melanoma. ( 21863619 )
2011
17
Primary orbital melanoma with poliosis and a palpable mass. ( 21987690 )
2011
18
Palliative surgery for contralateral metastasis of orbital melanoma to prevent blindness. ( 18925919 )
2008
19
Characterization of an orbital melanoma and mucosa associated lymphoid tissue (MALT) lymphoma by dual phase N-isopropyl-p-I-123 iodoamphetamine. ( 17667440 )
2007
20
Contralateral orbital melanoma 28 years following enucleation for choroidal melanoma. ( 18097971 )
2007
21
Primary orbital melanoma without ocular involvement in a Balinese cat. ( 16604977 )
2006
22
Primary orbital melanoma treated with iodine-125 plaque radiotherapy. ( 17056373 )
2006
23
Primary orbital melanoma associated with a blue nevus. ( 15942508 )
2005
24
Aggressive primary orbital melanoma in a young white man with no predisposing ocular features. ( 14718309 )
2004
25
Primary orbital melanoma associated with an occult episcleral nevus. ( 14769613 )
2004
26
Unusual metastatic features in a patient with concomitant malignant orbital melanoma and prostate carcinoma. ( 15015669 )
2004
27
Loss of antigen-processing molecules in primary orbital melanoma. ( 14685900 )
2003
28
Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma. ( 14685899 )
2003
29
Primary orbital melanoma masquerading as vascular anomalies. ( 11913882 )
2002
30
Orbital melanoma metastatic from contralateral choroid: management by complete surgical resection. ( 12358296 )
2002
31
Primary orbital melanoma in a child. ( 10918242 )
2000
32
Primary orbital melanoma associated with oculodermal melanocytosis. ( 12045961 )
2000
33
Orbital melanoma presenting as orbital cellulitis: a clinicopathologic report. ( 9700739 )
1998
34
A case of primary orbital melanoma treated by local excision. ( 8562560 )
1995
35
Necrotic orbital melanoma arising de novo. ( 8457515 )
1993
36
Primary orbital melanoma associated with orbital melanocytosis. ( 2383203 )
1990
37
Orbital melanoma. ( 7294632 )
1981
38
Primary orbital melanoma. ( 718518 )
1978
39
Primary orbital melanoma. ( 4835051 )
1974
40
Primary orbital melanoma. ( 5946390 )
1966
41
AN ENCAPSULATED ORBITAL MELANOMA. ( 18170019 )
1944

Variations for Orbital Melanoma

Expression for Orbital Melanoma

Search GEO for disease gene expression data for Orbital Melanoma.

Pathways for Orbital Melanoma

GO Terms for Orbital Melanoma

Cellular components related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.26 TAP1 TAPBP
2 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.16 TAP1 TAPBP
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 CANX TAPBP
4 MHC class I peptide loading complex GO:0042824 8.62 TAP1 TAPBP

Biological processes related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.32 TAP1 TAPBP
2 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 TAP1 TAPBP
3 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.16 TAP1 TAPBP
4 amide transport GO:0042886 8.96 TAP1 TAPBP
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.8 CANX TAP1 TAPBP

Molecular functions related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 unfolded protein binding GO:0051082 9.37 CANX TAPBP
2 peptide antigen binding GO:0042605 9.32 TAP1 TAPBP
3 MHC class I protein binding GO:0042288 9.26 TAP1 TAPBP
4 TAP1 binding GO:0046978 9.16 TAP1 TAPBP
5 peptide antigen-transporting ATPase activity GO:0015433 8.96 TAP1 TAPBP
6 TAP2 binding GO:0046979 8.62 TAP1 TAPBP

Sources for Orbital Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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