MCID: ORB015
MIFTS: 25

Orbital Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Orbital Melanoma

MalaCards integrated aliases for Orbital Melanoma:

Name: Orbital Melanoma 53 72

Classifications:



External Ids:

UMLS 72 C3898089

Summaries for Orbital Melanoma

MalaCards based summary : Orbital Melanoma is related to melanoma, uveal and melanoma. An important gene associated with Orbital Melanoma is CANX (Calnexin), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. Affiliated tissues include prostate and eye, and related phenotypes are G0/1 arrest and Multipolar spindles

Related Diseases for Orbital Melanoma

Symptoms & Phenotypes for Orbital Melanoma

GenomeRNAi Phenotypes related to Orbital Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 9.13 CANX SF3B1 TAPBP
2 Multipolar spindles GR00222-A-1 8.62 EIF1AX SF3B1

MGI Mouse Phenotypes related to Orbital Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 CANX GNAQ SF3B1 TAP1 TAPBP

Drugs & Therapeutics for Orbital Melanoma

Search Clinical Trials , NIH Clinical Center for Orbital Melanoma

Genetic Tests for Orbital Melanoma

Anatomical Context for Orbital Melanoma

MalaCards organs/tissues related to Orbital Melanoma:

41
Prostate, Eye

Publications for Orbital Melanoma

Articles related to Orbital Melanoma:

(show top 50) (show all 74)
# Title Authors PMID Year
1
Genetic Profiling of Primary Orbital Melanoma: An Analysis of 6 Cases with Clinicopathologic Correlation. 38
30605742 2019
2
Chemoreduction of Orbital Recurrence of Uveal Melanoma by Intra-Arterial Melphalan. 38
31049326 2019
3
Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis. 38
30558566 2018
4
Primary orbital melanoma: a case series and literature review. 38
29388848 2018
5
Correction to: Figueira et al., Primary orbital melanoma: a case series and literature review. 38
29513628 2018
6
Radiation therapy for deep periocular cancer treatments when protons are unavailable: is combining electrons and orthovoltage therapy beneficial? 38
30053071 2018
7
Primary orbital melanoma treated with orbital exenteration and postoperative radiotherapy: A case report and review of the literature. 38
29394463 2018
8
7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T. 38
27915116 2018
9
Profile of eyelid malignancy in a Tertiary Health Care Center in North India. 38
28862213 2017
10
Malignant Orbital Melanoma Associated with Oculodermal Melanocytosis. 38
28335938 2017
11
Orbital melanoma masquerading as a "Galloping haemangioma". 38
28388343 2017
12
Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients. 38
29326884 2017
13
Giant Orbital Melanoma in a Heroin Abuser. 38
28559841 2017
14
Presentation, Treatment, and Prognosis of Secondary Melanoma within the Orbit. 38
28690979 2017
15
Orbital melanoma with calcification: A diagnostic dilemma. 38
28112137 2016
16
Melanoma-Associated Spongiform Scleropathy in Oculodermal Melanocytosis with Primary Orbital Melanoma. 38
27843909 2016
17
Orbital exenteration in immunodeficiency virus-infected patients. 38
27799732 2016
18
New Translational Research in the Medical Management of Orbital Melanoma. 38
26959130 2016
19
Poliosis circumscripta unmasking a scalp melanoma. 38
25546496 2015
20
Melanocytic Ophthalmic Neoplasms of the Domestic Veterinary Species: A Review. 38
27154598 2015
21
Orbital melanoma: Recurrence versus primary: A diagnostic dilemma. 38
25494149 2014
22
Extrascleral extension of choroidal melanoma: post-enucleation high-dose-rate interstitial brachytherapy of the orbit. 38
24139892 2014
23
Primary orbital melanoma in association with cellular blue nevus. 38
27843414 2014
24
Primary orbital melanoma combined with giant divided nevus of the eyelid. 38
24406601 2014
25
[A thirty-four-year-old woman with primary orbital melanoma]. 38
23877821 2013
26
Physiologic positron emission tomography/CT imaging of an integrated orbital implant. 38
21386739 2012
27
Primary orbital melanoma with poliosis and a palpable mass. 38
21987690 2011
28
Orbital melanoma. 38
21863619 2011
29
Treated choroidal melanoma with late metastases to the contralateral orbit. 38
21151543 2009
30
Ocular melanoma: relatively rare but requiring respect. 38
19095158 2009
31
Orbital metastasis: clinical features, management and outcome. 38
19839900 2009
32
Primary malignant melanoma of the orbit in an African-American man. 38
19033846 2008
33
Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. 38
18711275 2008
34
Palliative surgery for contralateral metastasis of orbital melanoma to prevent blindness. 38
18925919 2008
35
Contralateral orbital melanoma 28 years following enucleation for choroidal melanoma. 38
18097971 2007
36
[Surgical management of orbital malignant melanoma: our experience and a report of three cases]. 38
17952825 2007
37
Characterization of an orbital melanoma and mucosa associated lymphoid tissue (MALT) lymphoma by dual phase N-isopropyl-p-I-123 iodoamphetamine. 38
17667440 2007
38
Navigation-assisted resection of a primary extraocular melanoma of the orbit. 38
17649776 2007
39
Primary orbital melanoma treated with iodine-125 plaque radiotherapy. 38
17056373 2006
40
[Ocular melanoma: immunohistochemical evaluation of the potentially predictive markers of prognosis. Preliminary results]. 38
16885827 2006
41
Primary orbital melanoma without ocular involvement in a Balinese cat. 38
16604977 2006
42
Primary orbital melanoma associated with a blue nevus. 38
15942508 2005
43
Primary orbital melanoma associated with an occult episcleral nevus. 38
14769613 2004
44
Unusual metastatic features in a patient with concomitant malignant orbital melanoma and prostate carcinoma. 38
15015669 2004
45
Aggressive primary orbital melanoma in a young white man with no predisposing ocular features. 38
14718309 2004
46
Loss of antigen-processing molecules in primary orbital melanoma. 38
14685900 2003
47
Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma. 38
14685899 2003
48
Plaque radiotherapy for selected orbital malignancies: preliminary observations: the 2002 Montgomery Lecture, part 2. 38
12644752 2003
49
Orbital melanoma metastatic from contralateral choroid: management by complete surgical resection. 38
12358296 2002
50
Primary orbital melanoma masquerading as vascular anomalies. 38
11913882 2002

Variations for Orbital Melanoma

Expression for Orbital Melanoma

Search GEO for disease gene expression data for Orbital Melanoma.

Pathways for Orbital Melanoma

GO Terms for Orbital Melanoma

Cellular components related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.26 TAPBP TAP1
2 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.16 TAPBP TAP1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 TAPBP CANX
4 MHC class I peptide loading complex GO:0042824 8.62 TAPBP TAP1

Biological processes related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.26 TAPBP TAP1
2 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.16 TAPBP TAP1
3 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 8.96 TAPBP TAP1
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.8 TAPBP TAP1 CANX

Molecular functions related to Orbital Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 unfolded protein binding GO:0051082 9.37 TAPBP CANX
2 peptide antigen binding GO:0042605 9.32 TAPBP TAP1
3 MHC class I protein binding GO:0042288 9.26 TAPBP TAP1
4 TAP1 binding GO:0046978 9.16 TAPBP TAP1
5 TAP2 binding GO:0046979 8.96 TAPBP TAP1
6 peptide antigen-transporting ATPase activity GO:0015433 8.62 TAPBP TAP1

Sources for Orbital Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....