MCID: ORB008
MIFTS: 32

Orbital Plasma Cell Granuloma

Categories: Bone diseases

Aliases & Classifications for Orbital Plasma Cell Granuloma

MalaCards integrated aliases for Orbital Plasma Cell Granuloma:

Name: Orbital Plasma Cell Granuloma 12 15 17
Orbital Myositis 12 17 70
Orbital Pseudotumor 44 70
Plasma Cell Granuloma, Orbital 70
Pseudotumor of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9369
MeSH 44 D016727
SNOMED-CT 67 72789009
ICD10 32 H05.11
UMLS 70 C0085270 C2350387 C2350476

Summaries for Orbital Plasma Cell Granuloma

MalaCards based summary : Orbital Plasma Cell Granuloma, also known as orbital myositis, is related to exophthalmos and tolosa-hunt syndrome. An important gene associated with Orbital Plasma Cell Granuloma is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways is IgA-Producing B Cells in the Intestine. The drugs Methylprednisolone hemisuccinate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and kidney, and related phenotype is immune system.

Related Diseases for Orbital Plasma Cell Granuloma

Diseases related to Orbital Plasma Cell Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.9 TSHR PRTN3
2 tolosa-hunt syndrome 30.7 PRTN3 CRP
3 chickenpox 30.4 CTLA4 CRP
4 posterior scleritis 30.3 PRTN3 CRP
5 scleritis 30.3 PRTN3 CTLA4 CRP
6 vasculitis 30.1 PRTN3 CTLA4 CRP
7 thyroiditis 30.1 TSHR CTLA4 CRP
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.0 TSHR CTLA4
9 granulomatous angiitis 30.0 PRTN3 CRP
10 cogan syndrome 30.0 PRTN3 CRP
11 granulomatous myositis 29.9 PRTN3 PIK3C2A
12 cholangitis 29.9 PRTN3 CTLA4 CRP
13 facial paralysis 29.9 PRTN3 CRP
14 juvenile rheumatoid arthritis 29.8 LTA CTLA4 CRP
15 exanthem 29.8 PRTN3 PIK3C2A CTLA4 CRP
16 temporal arteritis 29.7 PRTN3 CTLA4 CRP
17 granulomatosis with polyangiitis 29.7 PRTN3 CTLA4 CRP
18 psoriatic arthritis 29.7 LTA CTLA4 CRP
19 orbital disease 29.6 TSHR PRTN3 CTLA4 CRP
20 pericardial effusion 29.6 PRTN3 PIK3C2A CRP
21 graves' disease 29.3 TSHR LTA CTLA4
22 hyperthyroidism 29.3 TSHR PRTN3 CTLA4 CRP
23 disease by infectious agent 29.3 PRTN3 LTA CRP
24 inflammatory bowel disease 29.1 PRTN3 LTA CTLA4 CRP
25 rheumatoid arthritis 29.0 PRTN3 LTA CTLA4 CRP
26 thrombocytopenia 29.0 PIK3C2A LTA CTLA4 CRP
27 autoimmune disease 28.6 TSHR PRTN3 LTA CTLA4 CRP
28 myositis 11.0
29 crohn's disease 10.5
30 kearns-sayre syndrome 10.4
31 herpes zoster 10.4
32 herpes zoster ophthalmicus 10.3
33 cellulitis 10.3
34 eye disease 10.3
35 orbital cellulitis 10.3
36 strabismus 10.3
37 ptosis 10.3
38 lyme disease 10.3
39 uveitis 10.3
40 mechanical strabismus 10.3
41 cluster headache 10.3
42 headache 10.3
43 granulomatous hepatitis 10.2 CTLA4 CRP
44 myocarditis 10.2
45 lupus erythematosus 10.2
46 ecthyma 10.2 MORC3 CRP
47 myopathy 10.2
48 giant cell myocarditis 10.2
49 intestinal perforation 10.2 CTLA4 CRP
50 anca-associated vasculitis 10.2 PRTN3 CTLA4

Graphical network of the top 20 diseases related to Orbital Plasma Cell Granuloma:



Diseases related to Orbital Plasma Cell Granuloma

Symptoms & Phenotypes for Orbital Plasma Cell Granuloma

MGI Mouse Phenotypes related to Orbital Plasma Cell Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CRP CTLA4 LTA PIK3C2A PRTN3 TRIM33

Drugs & Therapeutics for Orbital Plasma Cell Granuloma

Drugs for Orbital Plasma Cell Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
5
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
6
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
9
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
10 Gastrointestinal Agents Phase 3
11 Hormones Phase 3
12 Methylprednisolone Acetate Phase 3
13 Triamcinolone diacetate Phase 3
14 Triamcinolone hexacetonide Phase 3
15 Antiemetics Phase 3
16 Neuroprotective Agents Phase 3
17 Antineoplastic Agents, Hormonal Phase 3
18 Protective Agents Phase 3
19 triamcinolone acetonide Phase 3
20 Hormone Antagonists Phase 3
21 glucocorticoids Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Calcium Supplement Phase 3
24 Calcium, Dietary Phase 3
25
Calcium Nutraceutical Phase 3 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial Recruiting NCT03958344 Phase 3 Prednisolone;Triamcinolone + Betamethason
2 Survey of Patients With Idiopathic Orbital Inflammation Syndrome (IOIS): Clinical, Morphological and Pathological Features and Treatment Outcomes Completed NCT01443000
3 MRI for the Etiological Diagnosis of Orbital Tumours Completed NCT02401906

Search NIH Clinical Center for Orbital Plasma Cell Granuloma

Cochrane evidence based reviews: orbital pseudotumor

Genetic Tests for Orbital Plasma Cell Granuloma

Anatomical Context for Orbital Plasma Cell Granuloma

MalaCards organs/tissues related to Orbital Plasma Cell Granuloma:

40
Eye, Heart, Kidney, Lung, Thyroid, Skin, Myeloid

Publications for Orbital Plasma Cell Granuloma

Articles related to Orbital Plasma Cell Granuloma:

(show top 50) (show all 312)
# Title Authors PMID Year
1
Histopathologic Findings in Idiopathic Orbital Myositis. 61
32926913 2021
2
New Onset of Unilateral Orbital Myositis following Mild COVID-19 Infection. 61
33797304 2021
3
Myositis of an Extraocular Muscle, a Possible Drug Reaction: Histopathologic and Immunopathologic Analysis. 61
33587420 2021
4
Pseudo-Duane retraction syndrome after orbital myositis. 61
33652102 2021
5
Re: "Orbital Myositis: A Comprehensive Review and Reclassification". 61
33395200 2021
6
Reply re: "Orbital Myositis: A Comprehensive Review and Reclassification". 61
33395201 2021
7
Orbital myositis with herpes zoster ophthalmicus. 61
33509965 2021
8
Limitation of adduction in a patient with multiple sclerosis related to orbital myositis. 61
33504399 2021
9
More Than Meets the Eye: Idiopathic Orbital Inflammation Mimicking Orbital Cellulitis. 61
33585140 2021
10
Giant cell myositis and myocarditis revisited. 61
33458585 2020
11
P029 Left Orbital Myositis in a Patient with Crohn's Disease in Remission with Vedolizumab. 61
33566503 2020
12
Reply to: Cluster headache by orbital myositis. Comment: Orbital myositis triggering oxygen-responsive cluster headache. 61
32985221 2020
13
Cluster headache by orbital myositis. Comment: Orbital myositis triggering oxygen-responsive cluster headache. 61
32722937 2020
14
Orbital myositis: a diagnostic challenge. 61
33386116 2020
15
Extraocular Muscle Palsy in Patients with Chronic Orbital Myositis. 61
33095116 2020
16
Diplopia and ocular pain due to orbital myositis. 61
32577849 2020
17
Unilateral Ptosis, Proptosis, and Orbital Myositis After Shingles Vaccination. 61
33079763 2020
18
A rare case of orbital myositis. 61
33754537 2020
19
Re: "Orbital Myositis: A Comprehensive Review and Reclassification". 61
32925672 2020
20
Granulomatosis with polyangiitis presenting as recurrent, multifocal orbital myositis. 61
32878531 2020
21
Reply re: "Orbital Myositis: A Comprehensive Review and Reclassification". 61
32925673 2020
22
Atypical Cogan Syndrome Featuring Orbital Myositis and Dacryoadenitis. 61
32991499 2020
23
Invasive rhino-orbital-cerebral aspergillosis in an immunocompetent patient. 61
32507472 2020
24
Multi-organ IgG4-related disease continues to mislead clinicians: A case report and literature review. 61
32874981 2020
25
Orbital myositis in systemic lupus erythematosus: A case report and literature review. 61
32809933 2020
26
Treatment of idiopathic orbital myositis with frequent relapses: First case with tacrolimus and review of literature. 61
32668345 2020
27
Plus-minus lid syndrome with ataxia and severe apathy-A rare manifestation of midbrain infarct. 61
32675453 2020
28
Inflammatory choroidal neovascularization associated with immunoglobulin G4-related disease: a case report. 61
32622368 2020
29
Orbital compartment syndrome as the first manifestation of SLE. 61
32152917 2020
30
Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma. 61
32461486 2020
31
Acute orbital myositis preceding vesicular rash eruption in herpes zoster ophthalmicus. 61
31879064 2020
32
An unusual case of orbital myositis in a patient with HLA B-27-associated uveitis. 61
32174589 2020
33
Clinical Features of Ocular Motility in Idiopathic Orbital Myositis. 61
32325733 2020
34
Case report: Orbital myositis triggering oxygen-responsive cluster headache. 61
31345050 2020
35
Orbital Myositis: A Comprehensive Review and Reclassification. 61
31261163 2020
36
Idiopathic inferior rectus myositis: A rare cause of diplopia and a therapeutic success. 61
33542993 2020
37
Case Report: Orbital Myositis and Myasthenia Gravis as Symptoms of Immune Reconstitution Inflammatory Syndrome in a Patient With Human Immunodeficiency Virus Infection. 61
33381117 2020
38
Keep an Eye Out for Crohn's Disease: Orbital Myositis as the Initial Sign before Gastrointestinal Manifestations. 61
33313010 2020
39
Acute Unilateral Ptosis and Myositis Following the H1N1 Influenza Vaccine. 61
31770175 2020
40
Neuro-ophthalmic Complications of Immune Checkpoint Inhibitors: A Systematic Review. 61
33173368 2020
41
Intracranial actinomycosis of odontogenic origin masquerading as auto-immune orbital myositis: a fatal case and review of the literature. 61
31477035 2019
42
18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications. 61
30664602 2019
43
Technique and Results of Permanent Medial Tarsorrhaphy for Complex Eyelid Malposition. 61
30856627 2019
44
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. 61
30134390 2019
45
Neuro-ophthalmic complications of IgG4-related disease. 61
30199519 2018
46
Herpes Zoster Ophthalmicus With Orbital Findings Preceding Skin Rash. 61
29634608 2018
47
A Case of Orbital Myositis Presenting With Dizziness. 61
30087737 2018
48
Orbital myositis as a manifestation of primary antiphospholipid syndrome. 61
29124440 2018
49
Case Series: Herpes Zoster Ophthalmicus with Acute Orbital Inflammation. 61
29554007 2018
50
Orbital Myositis: An Underrecognized Clinical Syndrome with a Need of Management Guidelines. 61
29334042 2018

Variations for Orbital Plasma Cell Granuloma

Expression for Orbital Plasma Cell Granuloma

Search GEO for disease gene expression data for Orbital Plasma Cell Granuloma.

Pathways for Orbital Plasma Cell Granuloma

Pathways related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 LTA CTLA4

GO Terms for Orbital Plasma Cell Granuloma

Biological processes related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of fibroblast proliferation GO:0048147 8.62 MORC3 LTA

Sources for Orbital Plasma Cell Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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