MCID: ORB008
MIFTS: 33

Orbital Plasma Cell Granuloma

Categories: Eye diseases

Aliases & Classifications for Orbital Plasma Cell Granuloma

MalaCards integrated aliases for Orbital Plasma Cell Granuloma:

Name: Orbital Plasma Cell Granuloma 12 15 17
Orbital Myositis 12 17 74
Orbital Pseudotumor 45 74
Plasma Cell Granuloma, Orbital 74
Pseudotumor of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9369
MeSH 45 D016727
SNOMED-CT 69 72789009
ICD10 34 H05.11

Summaries for Orbital Plasma Cell Granuloma

MalaCards based summary : Orbital Plasma Cell Granuloma, also known as orbital myositis, is related to myositis and crohn's disease. An important gene associated with Orbital Plasma Cell Granuloma is TNFRSF1B (TNF Receptor Superfamily Member 1B), and among its related pathways/superpathways are Allograft rejection and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include eye, heart and thyroid, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Orbital Plasma Cell Granuloma

Diseases related to Orbital Plasma Cell Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 myositis 10.9
2 crohn's disease 10.3
3 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
4 benign struma ovarii 10.3 SMUG1 TSHR
5 chondromalacia 10.3 SMUG1 TNFRSF1B
6 juvenile ankylosing spondylitis 10.3 MRAP TNFRSF1B
7 herpes zoster 10.3
8 scleral disease 10.3 MRAP TNFRSF1B
9 pustulosis of palm and sole 10.3 MRAP TNFRSF1B
10 iritis 10.3 MRAP TNFRSF1B
11 tenosynovitis 10.3 MRAP TNFRSF1B
12 pericoronitis 10.3 NCAM1 TNFRSF1B
13 rhinoscleroma 10.3 NCAM1 TNFRSF1B
14 aortitis 10.2 MRAP SMUG1
15 pericardium disease 10.2 PIK3C2A SMUG1
16 transient arthritis 10.2 MRAP TNFRSF1B
17 plexopathy 10.2 PIK3C2A SMUG1
18 penile disease 10.2 IFNA2 MRAP
19 herpes zoster ophthalmicus 10.2
20 peroneal neuropathy 10.2 MME TNFRSF1B
21 gallbladder small cell carcinoma 10.2 NCAM1 SMUG1
22 cogan syndrome 10.2 SMUG1 TNFRSF1B
23 panuveitis 10.2 MRAP TNFRSF1B
24 mediastinal cancer 10.2 NCAM1 SMUG1
25 conjunctival disease 10.2 IFNA2 MRAP
26 myocarditis 10.2
27 tracheal cancer 10.2 SMUG1 TNFRSF1B
28 palindromic rheumatism 10.2 MRAP TNFRSF1B
29 central nervous system hematologic cancer 10.1 MME SMUG1
30 arthritis 10.1
31 lyme disease 10.1
32 lupus erythematosus 10.1
33 giant cell myocarditis 10.1
34 lung combined type small cell carcinoma 10.1 MME NCAM1
35 extrahepatic bile duct adenocarcinoma 10.1 MME NCAM1
36 myxedema 10.1 CTLA4 TSHR
37 lung lymphoma 10.1 NCAM1 SMUG1
38 spermatocele 10.1 MME NCAM1
39 histrionic personality disorder 10.1 KNTC1 MME
40 rete testis neoplasm 10.1 MME NCAM1
41 hypersensitivity reaction type iv disease 10.1 MRAP SMUG1 TNFRSF1B
42 rheumatoid arthritis 10.1
43 cellulitis 10.1
44 cystadenofibroma 10.1 MME NCAM1
45 dependent personality disorder 10.1 KNTC1 MME
46 anterior scleritis 10.1 MRAP NCAM1 TNFRSF1B
47 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 CTLA4 TSHR
48 autoimmune disease of endocrine system 10.0 CTLA4 TSHR
49 nephrogenic adenofibroma 10.0 MME NCAM1
50 systemic lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Orbital Plasma Cell Granuloma:



Diseases related to Orbital Plasma Cell Granuloma

Symptoms & Phenotypes for Orbital Plasma Cell Granuloma

MGI Mouse Phenotypes related to Orbital Plasma Cell Granuloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 CTLA4 KNTC1 MME PIK3C2A SMUG1 SST
2 mortality/aging MP:0010768 9.23 CTLA4 KNTC1 NCAM1 PIK3C2A SMUG1 SST

Drugs & Therapeutics for Orbital Plasma Cell Granuloma

Search Clinical Trials , NIH Clinical Center for Orbital Plasma Cell Granuloma

Cochrane evidence based reviews: orbital pseudotumor

Genetic Tests for Orbital Plasma Cell Granuloma

Anatomical Context for Orbital Plasma Cell Granuloma

MalaCards organs/tissues related to Orbital Plasma Cell Granuloma:

42
Eye, Heart, Thyroid

Publications for Orbital Plasma Cell Granuloma

Articles related to Orbital Plasma Cell Granuloma:

(show top 50) (show all 162)
# Title Authors Year
1
Orbital Myositis: An Underrecognized Clinical Syndrome with a Need of Management Guidelines. ( 29334042 )
2018
2
Orbital myositis as a manifestation of primary antiphospholipid syndrome. ( 29124440 )
2018
3
A Case of Orbital Myositis Presenting With Dizziness. ( 30087737 )
2018
4
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. ( 28195080 )
2017
5
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ( 28772042 )
2017
6
Unilateral Migratory Relapsing Orbital Myositis While on Immunosuppressant Therapy: An Uncommon Entity. ( 25564259 )
2017
7
Decreased CD3-CD16+CD56+ natural killer cell counts in children with orbital myositis: a clue to disease activity. ( 28955482 )
2017
8
Idiopathic orbital myositis presenting as cluster headache: a case report. ( 28342020 )
2017
9
Orbital myositis presenting with only unilateral orbital pain. ( 28578311 )
2017
10
Alternating and Relapsing Migratory Orbital Myositis. ( 29230978 )
2017
11
Orbital Myositis as Both a Presenting and Associated Extraintestinal Sign of Crohn's Disease. ( 26154590 )
2017
12
Orbital Myositis. ( 27462048 )
2017
13
Shingles as the underlying cause of orbital myositis in an adolescent: A case report. ( 29503961 )
2017
14
Orbital myositis revealing a vegetal intraorbital foreign body: a case report. ( 29877559 )
2017
15
Orbital myositis: A rare complication of ophthalmic herpes zoster. ( 27595510 )
2016
16
Teaching NeuroImages: Painful diplopia and Crohn disease: Think about orbital myositis. ( 27527545 )
2016
17
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis. ( 27009192 )
2016
18
Orbital Myositis: Evaluating Five New Cases Regarding Clinical and Radiological Features. ( 28360792 )
2016
19
Medical and Surgical Treatment in Pediatric Orbital Myositis Associated with Coxsackie Virus. ( 26550508 )
2015
20
Fulminant lymphocytic myocarditis associated with orbital myositis and diaphragmatic paralysis. ( 26481055 )
2015
21
Unique case of orbital myositis and dacryoadenitis preceding the vesicular rash of herpes zoster ophthalmicus. ( 26222135 )
2015
22
Orbital myositis secondary to statin therapy. ( 26510805 )
2015
23
"Orbiting around" the orbital myositis: clinical features, differential diagnosis and therapy. ( 26477021 )
2015
24
Painful ophthalmoplaegia secondary to orbital myositis. ( 25948858 )
2015
25
Idiopathic Orbital Myositis in a 9-Year-Old Girl: A Case Report. ( 26199706 )
2015
26
Orbital Myositis and Primary Sjögren Syndrome. ( 26233955 )
2015
27
Orbital myositis: a side effect of interferon alpha 2b treatment. ( 25565215 )
2015
28
Orbital myositis associated with discoid lupus erythematosus. ( 24335011 )
2014
29
Acute monolateral proptosis and orbital myositis in a patient with discoid lupus erythematosus: a case report. ( 25410119 )
2014
30
External ophthalmoplegia with orbital myositis in an adult patient after chickenpox infection. ( 24835802 )
2014
31
Successful "medical" orbital decompression with adjunctive rituximab for severe visual loss in IgG4-related orbital inflammatory disease with orbital myositis. ( 24481505 )
2014
32
Orbital myositis. ( 24481807 )
2014
33
Idiopathic orbital myositis. ( 24670274 )
2014
34
Idiopathic inflammatory orbital myositis presenting with vision loss. ( 25207637 )
2014
35
Systemic Lupus Erythematosus Presenting as Orbital Myositis. ( 27928311 )
2014
36
Adalimumab for orbital myositis in a patient with Crohn's disease who discontinued infliximab: a case report and review of the literature. ( 23556424 )
2013
37
Orbital myositis and Crohn's disease. ( 24267905 )
2013
38
Orbital myositis as manifestation of systemic lupus erythematosus--a case report. ( 22967713 )
2013
39
Idiopathic orbital myositis associated with Graves' disease. ( 23545676 )
2013
40
Orbital myositis in BehAset's disease. ( 24326194 )
2013
41
Orbital myositis associated with celiac disease. ( 23842704 )
2013
42
Recurrent orbital myositis in undifferentiated connective tissue disease. ( 22840478 )
2013
43
A unique case of foreign-body associated orbital myositis. ( 22082591 )
2012
44
IgG4-related systemic disease as a cause of "idiopathic" orbital inflammation, including orbital myositis, and trigeminal nerve involvement. ( 22018678 )
2012
45
Acute orbital myositis before Herpes zoster ophthalmicus. ( 22474562 )
2012
46
Painful ophthalmoplegia with simultaneous orbital myositis, optic and oculomotor nerve inflammation and trigeminal nucleus involvement in a patient with herpes zoster ophthalmicus. ( 23109414 )
2012
47
Orbital myositis and psoriatic arthritis. ( 23217511 )
2012
48
Bilateral diffuse orbital myositis in a patient with relapsing ulcerative colitis. ( 22366668 )
2012
49
Orbital myositis associated with focal active colitis in a teenage girl. ( 22009155 )
2012
50
Painless orbital myositis. ( 22919201 )
2012

Variations for Orbital Plasma Cell Granuloma

Expression for Orbital Plasma Cell Granuloma

Search GEO for disease gene expression data for Orbital Plasma Cell Granuloma.

Pathways for Orbital Plasma Cell Granuloma

GO Terms for Orbital Plasma Cell Granuloma

Cellular components related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.23 CTLA4 KNTC1 MME MRAP NCAM1 PIK3C2A

Biological processes related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.13 IFNA2 SST TSHR
2 cell surface receptor signaling pathway GO:0007166 8.92 IFNA2 SST TNFRSF1B TSHR

Sources for Orbital Plasma Cell Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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