MCID: ORB008
MIFTS: 30

Orbital Plasma Cell Granuloma

Categories: Eye diseases

Aliases & Classifications for Orbital Plasma Cell Granuloma

MalaCards integrated aliases for Orbital Plasma Cell Granuloma:

Name: Orbital Plasma Cell Granuloma 12 15
Orbital Pseudotumor 44 73
Orbital Myositis 12 73
Plasma Cell Granuloma, Orbital 73
Pseudotumor of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9369
ICD10 33 H05.11
MeSH 44 D016727
SNOMED-CT 68 302901005 72789009

Summaries for Orbital Plasma Cell Granuloma

MalaCards based summary : Orbital Plasma Cell Granuloma, also known as orbital pseudotumor, is related to herpes zoster and systemic lupus erythematosus. An important gene associated with Orbital Plasma Cell Granuloma is TNFRSF1B (TNF Receptor Superfamily Member 1B), and among its related pathways/superpathways are Allograft rejection and Tuberculosis. Affiliated tissues include eye, myeloid and testes, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Related Diseases for Orbital Plasma Cell Granuloma

Diseases related to Orbital Plasma Cell Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 30.6 FCGR3A IFNA2
2 systemic lupus erythematosus 28.9 CTLA4 FCGR3A FCGR3B TNFRSF1B
3 transient neonatal neutropenia 10.6 FCGR3A FCGR3B
4 myositis 10.6
5 scleral disease 10.6 MRAP TNFRSF1B
6 iritis 10.6 MRAP TNFRSF1B
7 granulomatous hepatitis 10.6 IFNA2 TNFRSF1B
8 pustulosis of palm and sole 10.6 MRAP TNFRSF1B
9 spastic paraplegia 32, autosomal recessive 10.6 FCGR3A FCGR3B
10 tenosynovitis 10.6 MRAP TNFRSF1B
11 myxedema 10.6 CTLA4 TSHR
12 rheumatic myocarditis 10.5 FCGR3A FCGR3B
13 poliomyelitis 10.5 FCGR3A FCGR3B
14 penile disease 10.5 IFNA2 MRAP
15 acute salpingitis 10.5 MRAP TNFRSF1B
16 pericoronitis 10.5 NCAM1 TNFRSF1B
17 exanthema subitum 10.5 FCGR3A FCGR3B
18 rhinoscleroma 10.5 NCAM1 TNFRSF1B
19 panuveitis 10.4 MRAP TNFRSF1B
20 pleuropneumonia 10.4 FCGR3A FCGR3B
21 cryptococcosis 10.4 FCGR3A FCGR3B
22 autoimmune disease of endocrine system 10.4 CTLA4 TSHR
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4 CTLA4 TSHR
24 peroneal neuropathy 10.4 MME TNFRSF1B
25 palindromic rheumatism 10.3 MRAP TNFRSF1B
26 hypersensitivity reaction type iv disease 10.3 MRAP TNFRSF1B
27 mycosis fungoides 10.3 CTLA4 IFNA2 TNFRSF1B
28 hypopyon 10.3 MRAP NCAM1
29 ovarian cystic teratoma 10.3 FCGR3A FCGR3B IFNA2
30 granulomatous myositis 10.2 NCAM1 PIK3C2A TNFRSF1B
31 crohn's disease 10.1
32 lung combined type small cell carcinoma 10.1 MME NCAM1
33 histrionic personality disorder 10.1 KNTC1 MME
34 herpes zoster ophthalmicus 10.1
35 extrahepatic bile duct adenocarcinoma 10.1 MME NCAM1
36 diffuse infiltrative lymphocytosis syndrome 10.1 FCGR3A FCGR3B MRAP
37 myocarditis 10.1
38 dependent personality disorder 10.0 KNTC1 MME
39 carcinoid syndrome 10.0 IFNA2 SST
40 malignant skin fibrous histiocytoma 10.0 CTLA4 IFNA2 NCAM1
41 rete testis neoplasm 10.0 MME NCAM1
42 giant cell myocarditis 10.0
43 chronic nk-cell lymphocytosis 10.0 FCGR3A FCGR3B NCAM1
44 malignant dermis tumor 10.0 CTLA4 IFNA2 NCAM1
45 spermatocele 10.0 MME NCAM1
46 anterior scleritis 10.0 MRAP NCAM1 TNFRSF1B
47 cystadenofibroma 10.0 MME NCAM1
48 cellulitis 10.0
49 lupus erythematosus 10.0
50 nephrogenic adenofibroma 9.9 MME NCAM1

Graphical network of the top 20 diseases related to Orbital Plasma Cell Granuloma:



Diseases related to Orbital Plasma Cell Granuloma

Symptoms & Phenotypes for Orbital Plasma Cell Granuloma

GenomeRNAi Phenotypes related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 NCAM1 PIK3C2A FCGR3A MME

Drugs & Therapeutics for Orbital Plasma Cell Granuloma

Search Clinical Trials , NIH Clinical Center for Orbital Plasma Cell Granuloma

Cochrane evidence based reviews: orbital pseudotumor

Genetic Tests for Orbital Plasma Cell Granuloma

Anatomical Context for Orbital Plasma Cell Granuloma

MalaCards organs/tissues related to Orbital Plasma Cell Granuloma:

41
Eye, Myeloid, Testes

Publications for Orbital Plasma Cell Granuloma

Articles related to Orbital Plasma Cell Granuloma:

(show all 19)
# Title Authors Year
1
IgG4-Related Disease With Orbital Pseudotumors Treated With Rituximab Combined With Palpebral Surgery. ( 28055067 )
2017
2
A case report of hemicrania continua-like headache due to ipsilateral inflammatory orbital pseudotumor. ( 25168202 )
2014
3
Myeloid sarcoma: a rare case of an orbital mass mimicking orbital pseudotumor requiring neurosurgical intervention. ( 25478260 )
2014
4
Case of recurrent exophthalmos: angioedema versus idiopathic orbital pseudotumor. ( 24565625 )
2013
5
Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor. ( 23961032 )
2012
6
Orbital pseudotumor as an initial manifestation of multicentric Castleman's disease. ( 16365797 )
2005
7
Orbital pseudotumor in a child with juvenile rheumatoid arthritis. ( 15977874 )
2005
8
Central retinal vascular occlusion by orbital pseudotumor. ( 15187672 )
2004
9
Systemic malignant lymphoma 17 years after bilateral orbital pseudotumor. ( 15486778 )
2004
10
Giant-cell arteritis presenting as an orbital pseudotumor. ( 10555437 )
1999
11
Cystoid macular edema as an initial symptom of inflammatory orbital pseudotumor. ( 9216015 )
1997
12
A case of orbital pseudotumor masquerading as orbital cellulitis in a patient with proptosis and fever. ( 9368248 )
1997
13
Primary anetoderma and orbital pseudotumor. ( 7896484 )
1995
14
Orbital pseudotumor as a presenting sign of temporal arteritis. ( 7554567 )
1995
15
Herpes zoster ophthalmicus with orbital pseudotumor syndrome complicated by optic nerve infarction and cerebral granulomatous angiitis: MR-pathologic correlation. ( 8427086 )
1993
16
Intracranial extension of an orbital pseudotumor accompanied by internal carotid artery occlusion--case report. ( 1280778 )
1992
17
Role of testing for anticytoplasmic autoantibodies in the differential diagnosis of scleritis and orbital pseudotumor. ( 2388488 )
1990
18
Adult-onset Still's disease and inflammatory orbital pseudotumor. ( 3857478 )
1985
19
Orbital leiomyoma accompanied by orbital pseudotumor. ( 7131926 )
1982

Variations for Orbital Plasma Cell Granuloma

Expression for Orbital Plasma Cell Granuloma

Search GEO for disease gene expression data for Orbital Plasma Cell Granuloma.

Pathways for Orbital Plasma Cell Granuloma

GO Terms for Orbital Plasma Cell Granuloma

Cellular components related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.32 CTLA4 FCGR3A FCGR3B KNTC1 MME MRAP

Biological processes related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.26 CTLA4 FCGR3A FCGR3B TNFRSF1B
2 cell surface receptor signaling pathway GO:0007166 8.92 IFNA2 SST TNFRSF1B TSHR

Molecular functions related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3A FCGR3B

Sources for Orbital Plasma Cell Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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