MCID: ORB008
MIFTS: 31

Orbital Plasma Cell Granuloma

Categories: Bone diseases

Aliases & Classifications for Orbital Plasma Cell Granuloma

MalaCards integrated aliases for Orbital Plasma Cell Granuloma:

Name: Orbital Plasma Cell Granuloma 12 15 17
Orbital Myositis 12 17 71
Orbital Pseudotumor 43 71
Plasma Cell Granuloma, Orbital 71
Pseudotumor of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9369
MeSH 43 D016727
SNOMED-CT 67 72789009
ICD10 32 H05.11
UMLS 71 C0085270 C2350387 C2350476

Summaries for Orbital Plasma Cell Granuloma

MalaCards based summary : Orbital Plasma Cell Granuloma, also known as orbital myositis, is related to exophthalmos and tolosa-hunt syndrome. An important gene associated with Orbital Plasma Cell Granuloma is KNTC1 (Kinetochore Associated 1). The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid.

Related Diseases for Orbital Plasma Cell Granuloma

Diseases related to Orbital Plasma Cell Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.7 RHNO1 PRTN3 CRP
2 tolosa-hunt syndrome 30.6 PRTN3 CRP
3 orbital cellulitis 30.4 RHNO1 KNTC1 CRP
4 pharyngitis 30.2 TNFRSF1B CRP
5 chickenpox 30.2 TNFRSF1B CTLA4 CRP
6 cavernous sinus thrombosis 30.1 RHNO1 CRP
7 juvenile rheumatoid arthritis 30.1 TNFRSF1B CTLA4 CRP
8 psoriatic arthritis 30.0 TNFRSF1B CTLA4 CRP
9 granulomatous angiitis 29.9 PRTN3 CRP
10 cardiogenic shock 29.8 PIK3C2A CRP
11 cholangitis 29.8 PRTN3 CTLA4 CRP
12 granulomatous myositis 29.8 PRTN3 PIK3C2A
13 facial paralysis 29.7 PRTN3 CRP
14 sapho syndrome 29.7 TNFRSF1B MRAP
15 corneal dystrophy, band-shaped 29.6 TNFRSF1B MRAP
16 igg4-related disease 29.6 PRTN3 KNTC1 CRP
17 iridocyclitis 29.6 TNFRSF1B MRAP CRP
18 granulomatosis with polyangiitis 29.6 TNFRSF1B PRTN3 CTLA4 CRP
19 vasculitis 29.6 TNFRSF1B PRTN3 CTLA4 CRP
20 autoimmune disease 29.6 TNFRSF1B PRTN3 CTLA4 CRP
21 pyoderma 29.6 TNFRSF1B CRP
22 hyperthyroidism 29.5 PRTN3 CTLA4 CRP
23 paranasal sinus disease 29.5 RHNO1 PRTN3 CRP
24 sarcoidosis 1 29.4 TNFRSF1B MRAP CRP
25 posterior scleritis 29.4 PRTN3 MRAP CRP
26 endophthalmitis 29.3 MRAP CRP
27 pustulosis of palm and sole 29.3 TNFRSF1B MRAP CRP
28 iritis 29.3 TNFRSF1B MRAP CRP
29 optic papillitis 29.2 TNFRSF1B MRAP CRP
30 orbital disease 29.1 TNFRSF1B RHNO1 PRTN3 KNTC1 CRP
31 exanthem 29.0 TNFRSF1B PRTN3 PIK3C2A CTLA4 CRP
32 scleritis 28.9 TNFRSF1B PRTN3 MRAP CTLA4 CRP
33 pericardial effusion 28.8 PIK3C2A CRP
34 temporal arteritis 28.6 TNFRSF1B PRTN3 MTUS2 CTLA4 CRP
35 myositis 11.0
36 crohn's disease 10.4
37 kearns-sayre syndrome 10.4
38 herpes zoster 10.4
39 skin sarcoidosis 10.4 TNFRSF1B CTLA4
40 esophageal tuberculosis 10.3 TNFRSF1B CTLA4
41 herpes zoster ophthalmicus 10.3
42 rheumatoid arthritis interstitial lung disease 10.3 TNFRSF1B CRP
43 ankylosing spondylitis 1 10.3 TNFRSF1B CRP
44 mikulicz disease 10.3 KNTC1 CRP
45 cellulitis 10.3
46 eye disease 10.3
47 opportunistic bacterial infectious disease 10.3 TNFRSF1B CRP
48 nocardiosis 10.3 TNFRSF1B CRP
49 granulomatous hepatitis 10.3 TNFRSF1B CRP
50 acute maxillary sinusitis 10.3 RHNO1 CRP

Graphical network of the top 20 diseases related to Orbital Plasma Cell Granuloma:



Diseases related to Orbital Plasma Cell Granuloma

Symptoms & Phenotypes for Orbital Plasma Cell Granuloma

Drugs & Therapeutics for Orbital Plasma Cell Granuloma

Drugs for Orbital Plasma Cell Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
5
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
6 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
9
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
10 Hormones Phase 3
11 Antineoplastic Agents, Hormonal Phase 3
12 Methylprednisolone Acetate Phase 3
13 Hormone Antagonists Phase 3
14 glucocorticoids Phase 3
15 Neuroprotective Agents Phase 3
16 Antiemetics Phase 3
17 Protective Agents Phase 3
18 Triamcinolone diacetate Phase 3
19 triamcinolone acetonide Phase 3
20 Gastrointestinal Agents Phase 3
21 Triamcinolone hexacetonide Phase 3
22 Calcium Supplement Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Calcium, Dietary Phase 3
25
Calcium Nutraceutical Phase 3 7440-70-2 271
26
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
27 Immunologic Factors Phase 1, Phase 2
28 Antirheumatic Agents Phase 1, Phase 2
29 Antineoplastic Agents, Immunological Phase 1, Phase 2
30
Lenalidomide Approved Phase 1 191732-72-6 216326
31 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial Not yet recruiting NCT03958344 Phase 3 Prednisolone;Triamcinolone + Betamethason
2 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
4 Survey of Patients With Idiopathic Orbital Inflammation Syndrome (IOIS): Clinical, Morphological and Pathological Features and Treatment Outcomes Completed NCT01443000
5 MRI for the Etiological Diagnosis of Orbital Tumours Recruiting NCT02401906

Search NIH Clinical Center for Orbital Plasma Cell Granuloma

Cochrane evidence based reviews: orbital pseudotumor

Genetic Tests for Orbital Plasma Cell Granuloma

Anatomical Context for Orbital Plasma Cell Granuloma

MalaCards organs/tissues related to Orbital Plasma Cell Granuloma:

40
Eye, Bone, Thyroid, Heart, Skin, B Cells, Pituitary

Publications for Orbital Plasma Cell Granuloma

Articles related to Orbital Plasma Cell Granuloma:

(show top 50) (show all 280)
# Title Authors PMID Year
1
Orbital compartment syndrome as the first manifestation of SLE. 61
32152917 2020
2
Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma. 61
32461486 2020
3
Acute orbital myositis preceding vesicular rash eruption in herpes zoster ophthalmicus. 61
31879064 2020
4
Diplopia and ocular pain due to orbital myositis. 61
32577849 2020
5
Invasive rhino-orbital-cerebral aspergillosis in an immunocompetent patient. 61
32507472 2020
6
An unusual case of orbital myositis in a patient with HLA B-27-associated uveitis. 61
32174589 2020
7
Clinical Features of Ocular Motility in Idiopathic Orbital Myositis. 61
32325733 2020
8
Case report: Orbital myositis triggering oxygen-responsive cluster headache. 61
31345050 2020
9
Orbital Myositis: A Comprehensive Review and Reclassification. 61
31261163 2020
10
Acute Unilateral Ptosis and Myositis Following the H1N1 Influenza Vaccine. 61
31770175 2020
11
Intracranial actinomycosis of odontogenic origin masquerading as auto-immune orbital myositis: a fatal case and review of the literature. 61
31477035 2019
12
18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications. 61
30664602 2019
13
Technique and Results of Permanent Medial Tarsorrhaphy for Complex Eyelid Malposition. 61
30856627 2019
14
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. 61
30134390 2019
15
Neuro-ophthalmic complications of IgG4-related disease. 61
30199519 2018
16
Herpes Zoster Ophthalmicus With Orbital Findings Preceding Skin Rash. 61
29634608 2018
17
A Case of Orbital Myositis Presenting With Dizziness. 61
30087737 2018
18
Orbital myositis as a manifestation of primary antiphospholipid syndrome. 61
29124440 2018
19
Case Series: Herpes Zoster Ophthalmicus with Acute Orbital Inflammation. 61
29554007 2018
20
Orbital Myositis: An Underrecognized Clinical Syndrome with a Need of Management Guidelines. 61
29334042 2018
21
Idiopathic orbital myositis presenting as cluster headache: a case report. 61
28342020 2017
22
Alternating and Relapsing Migratory Orbital Myositis. 61
29230978 2017
23
Orbital myositis revealing a vegetal intraorbital foreign body: a case report. 61
29877559 2017
24
Orbital ultrasonography in the diagnosis of neoplastic extraocular muscle enlargement. 61
28704144 2017
25
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. 61
28772042 2017
26
Consensus on Diagnostic Criteria of Idiopathic Orbital Inflammation Using a Modified Delphi Approach. 61
28570731 2017
27
Orbital myositis presenting with only unilateral orbital pain. 61
28578311 2017
28
Orbital Myositis as Both a Presenting and Associated Extraintestinal Sign of Crohn's Disease. 61
26154590 2017
29
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. 61
28195080 2017
30
Shingles as the underlying cause of orbital myositis in an adolescent: A case report. 61
29503961 2017
31
Orbital Myositis. 61
27462048 2017
32
Orbital myositis: A rare complication of ophthalmic herpes zoster. 61
27595510 2017
33
Unilateral Migratory Relapsing Orbital Myositis While on Immunosuppressant Therapy: An Uncommon Entity. 61
25564259 2017
34
Not All Orbitopathy Is Graves': Discussion of Cases and Review of Literature. 61
28824545 2017
35
Decreased CD3-CD16+CD56+ natural killer cell counts in children with orbital myositis: a clue to disease activity. 61
28955482 2017
36
Teaching NeuroImages: Painful diplopia and Crohn disease: Think about orbital myositis. 61
27527545 2016
37
[New insights of myositis-specific and -associated autoantibodies in juvenile and adult type myositis]. 61
27452067 2016
38
Orbital Myositis: Evaluating Five New Cases Regarding Clinical and Radiological Features. 61
28360792 2016
39
Retained strabismus suture material masquerading as nonspecific orbital inflammation. 61
27112911 2016
40
"Orbiting around" the orbital myositis: clinical features, differential diagnosis and therapy. 61
26477021 2016
41
Unique case of orbital myositis and dacryoadenitis preceding the vesicular rash of herpes zoster ophthalmicus. 61
26222135 2016
42
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis. 61
27009192 2016
43
Fulminant lymphocytic myocarditis associated with orbital myositis and diaphragmatic paralysis. 61
26481055 2016
44
Orbital myositis secondary to statin therapy. 61
26510805 2015
45
Orbital Myositis and Primary Sjögren Syndrome. 61
26233955 2015
46
Idiopathic Orbital Myositis in a 9-Year-Old Girl: A Case Report. 61
26199706 2015
47
IgG4-Related Ophthalmic Disease. Part II: Clinical Aspects. 61
25564258 2015
48
Painful ophthalmoplaegia secondary to orbital myositis. 61
25948858 2015
49
IgG4-related ophthalmic disease. Part I: background and pathology. 61
25564257 2015
50
Acute unilateral isolated ptosis. 61
25564592 2015

Variations for Orbital Plasma Cell Granuloma

Expression for Orbital Plasma Cell Granuloma

Search GEO for disease gene expression data for Orbital Plasma Cell Granuloma.

Pathways for Orbital Plasma Cell Granuloma

GO Terms for Orbital Plasma Cell Granuloma

Biological processes related to Orbital Plasma Cell Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of T cell proliferation GO:0042129 8.62 TNFRSF1B CTLA4

Sources for Orbital Plasma Cell Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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